Cerebrolysin for acute ischaemic stroke

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new collection</label> </li> <li> <input type="radio" id="collections-action-panel-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="save_share" data-ga-action="collections" data-ga-label="collections_radio_existing"> <label for="collections-action-panel-existing">Add to an existing collection</label> </li> </ul> </div> <div class="controls-wrapper"> <div class="action-panel-control-wrap new-collections-controls"> <label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label> <input type="text" name="add-to-new-collection" id="collections-action-panel-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="save_share" data-ga-action="create_collection" data-ga-label="non_favorties_collection"> <div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div> </div> <div class="action-panel-control-wrap existing-collections-controls"> <label for="collections-action-panel-add-to-existing" class="action-panel-label"> Choose a collection: </label> <select id="collections-action-panel-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="save_share" data-ga-action="select_collection" data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"> </select> <div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br> <a href="#">Please try again</a> </div> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="save_share" data-ga-action="collections" data-ga-label="add"> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="collections" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="bibliography-action-panel" class="bibliography-action-panel action-panel in-progress-dots-panel" aria-hidden="true" data-bibliography-open-panel-enabled="false" data-bibliography-open-panel-url-hash="#open-bibliography-panel"> <div class="inner-wrap"> <h3 class="action-panel-heading"> Add to My Bibliography </h3> <form id="bibliography-action-panel-form" class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-add-to-bibliography-max-amount="100" data-add-to-bibliography-batch-size="10" data-bibliography-delegates-url="/list-bibliography-delegates/" data-add-to-bibliography-url="/add-to-bibliography/" data-get-article-ids-by-search-url="/get-article-ids-by-search/" data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/"> <input type="hidden" name="csrfmiddlewaretoken" value="ebmWVPuaiPB9d69E4mOHyUGW0bg8b1b1yCE0TvaphEhe1N9zVB8TqzRPJf4Ia2LH"> <div class="action-panel-control-wrap bibliographies-controls"> <div class="choice-group"> <ul class="bibliographies-action-add radio-group-items"> <li> <input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/> <label for="my-bibliography">My Bibliography</label> </li> </ul> </div> </div> <div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your delegates due to an error<br> <a href="#">Please try again</a> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to bibliography' panel" ref="linksrc=close_bibliography_panel" aria-controls="bibliography-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="mybib" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true" data-saved-search-open-panel-enabled="false" data-saved-search-open-panel-url-hash="#open-saved-search-panel"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your saved search </h2> <form id="saved-search-action-panel-form" class="saved-search-action-panel-form action-panel-content action-form" data-create-saved-search-url="/create-saved-search/" data-try-search-terms-url="/try-search-term/" data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/"> <input type="hidden" name="csrfmiddlewaretoken" value="ebmWVPuaiPB9d69E4mOHyUGW0bg8b1b1yCE0TvaphEhe1N9zVB8TqzRPJf4Ia2LH"> <div class="action-panel-control-wrap"> <label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk"> Name of saved search: </label> <input maxlength="200" type="text" name="saved-search-name" id="saved-search-name" class="saved-search-name" value="" required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="action-panel-control-wrap"> <label for="saved-search-term" class="action-panel-label required-field-asterisk"> Search terms: </label> <textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea> </div> <div class="test-search-term-wrap"> <a href="#" class="try-search-term">Test search terms</a> </div> <div class="choice-group action-panel-extra-margin-top"> <span class="action-panel-label" id="fieldset-label"> Would you like email updates of new search results? </span> <fieldset id="saved-search-alert" aria-describedby="fieldset-label"> <legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend> <ul class="radio-group-items"> <li> <input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked> <label for="saved-search-alert-yes" class="action-panel-label">Yes</label> </li> <li> <input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no"> <label for="saved-search-alert-no" class="action-panel-label">No</label> </li> </ul> </fieldset> </div> <div class="alert-schedule-wrap"> <div class="action-panel-control-wrap"> <label class="action-panel-label"> Email: </label> <span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span> </div> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="saved-search-frequency" class="action-panel-label"> Frequency: </label> <select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency"> <option value="monthly">Monthly</option> <option value="weekly">Weekly</option> <option value="daily">Daily</option> </select> </div> <div class="action-panel-control-wrap saved-search-monthly-additional"> <label for="saved-search-monthly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-monthly-on-day" class="no-border-panel-selector"> <option value="Sunday">The first Sunday</option> <option value="Monday">The first Monday</option> <option value="Tuesday">The first Tuesday</option> <option value="Wednesday">The first Wednesday</option> <option value="Thursday">The first Thursday</option> <option value="Friday">The first Friday</option> <option value="Saturday">The first Saturday</option> <option value="day">The first day</option> <option value="weekday">The first weekday</option> </select> </div> <div class="action-panel-control-wrap saved-search-weekly-additional"> <label for="saved-search-weekly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day"> <option value="Sunday">Sunday</option> <option value="Monday">Monday</option> <option value="Tuesday">Tuesday</option> <option value="Wednesday">Wednesday</option> <option value="Thursday">Thursday</option> <option value="Friday">Friday</option> <option value="Saturday">Saturday</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-report" class="action-panel-label"> Report format: </label> <select id="saved-search-report" class="no-border-panel-selector saved-search-report"> <option value="DocSum">Summary</option> <option value="DocSumText">Summary (text)</option> <option value="Abstract">Abstract</option> <option value="AbstractText">Abstract (text)</option> <option value="MEDLINE">PubMed</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-amount" class="action-panel-label"> Send at most: </label> <select id="saved-search-amount" class="no-border-panel-selector saved-search-amount"> <option value="1">1 item</option> <option value="5" selected>5 items</option> <option value="10">10 items</option> <option value="20">20 items</option> <option value="50">50 items</option> <option value="100">100 items</option> <option value="200">200 items</option> </select> </div> <div> <input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result"> <label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox"> Send even when there aren't any new results </label> </div> <div class="action-panel-control-wrap option-text-in-email-wrap"> <label for="saved-search-email-text" class="action-panel-label"> Optional text in email: </label> <textarea name="saved-search-email-text" id="saved-search-email-text" class="saved-search-email-text"></textarea> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Saving..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Save </button> <button class="action-panel-cancel" aria-label="Close 'Your saved search' panel" ref="linksrc=close_saved_search_panel" aria-controls="saved-search-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Create a file for external citation management software </h2> <form id="citation-manager-action-panel-form" class="action-panel-content action-form" action="/results-export-ids/" data-by-search-action="/results-export-search-data/" data-by-ids-action="/results-export-ids/" method="post" data-by-search-method="post" data-by-ids-method="post"> <input type="hidden" name="csrfmiddlewaretoken" value="ebmWVPuaiPB9d69E4mOHyUGW0bg8b1b1yCE0TvaphEhe1N9zVB8TqzRPJf4Ia2LH"> <input name="results-format" type="hidden" value="pubmed"/> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Sending..." data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="save"> Create file </button> <button class="action-panel-cancel" aria-label="Close 'Send citations to citation manager' panel" ref="linksrc=close_citation_manager_panel" aria-controls="citation-manager-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your RSS Feed </h2> <form id="rss-action-panel-form" class="rss-action-panel-form action-panel-content action-form" data-create-rss-feed-url="/create-rss-feed-url/" data-search-form-term-value=""> <input type="hidden" name="csrfmiddlewaretoken" value="ebmWVPuaiPB9d69E4mOHyUGW0bg8b1b1yCE0TvaphEhe1N9zVB8TqzRPJf4Ia2LH"> <div class="action-panel-control-wrap"> <label for="rss-name" class="action-panel-label required-field-asterisk"> Name of RSS Feed: </label> <input maxlength="200" placeholder="Name" type="text" name="rss-name" id="rss-name" class="rss-name" value='' required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="rss-limit-wrap"> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="rss-limit" class="action-panel-label"> Number of items displayed: </label> <select id="rss-limit" class="no-border-panel-selector rss-limit"> <option value="5">5</option> <option value="10">10</option> <option value="15" selected="selected">15</option> <option value="20">20</option> <option value="50">50</option> <option value="100">100</option> </select> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Creating..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Create RSS </button> <button class="action-panel-cancel" aria-label="Close 'Your RSS' panel" ref="linksrc=close_rss_panel" aria-controls="rss-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> <div class="action-panel-control-wrap rss-link-copy-wrap"> <label for="rss-link" class="usa-sr-only">RSS Link</label> <input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link"> <button type="button" disabled class="rss-link-copy-button disabled" data-ga-category="save_share" data-ga-action="rss" data-ga-label="copy"> Copy </button> </div> </form> </div> </div> </div> </div> <div class="article-page" id="article-page" data-article-pmid="37818733"> <aside class="page-sidebar"> <div class="inner-wrap"> <div class="full-text-links"> <div class="full-view"> <h3 class="title"> Full text links </h3> <div class="full-text-links-list"> <a class="link-item dialog-focus" 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value="ebmWVPuaiPB9d69E4mOHyUGW0bg8b1b1yCE0TvaphEhe1N9zVB8TqzRPJf4Ia2LH"><div class="choice-group" role="radiogroup"><ul class="radio-group-items"><li><input type="radio" id="collections-action-dialog-new" class="collections-new" name="collections" value="new" data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_radio_new"><label for="collections-action-dialog-new">Create a new collection</label></li><li><input type="radio" id="collections-action-dialog-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_radio_existing"><label for="collections-action-dialog-existing">Add to an existing collection</label></li></ul></div><div class="controls-wrapper"><div class="action-panel-control-wrap new-collections-controls"><label for="collections-action-dialog-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label><input type="text" name="add-to-new-collection" id="collections-action-dialog-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="collections_button" data-ga-action="create_collection" data-ga-label="non_favorties_collection"><div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div></div><div class="action-panel-control-wrap existing-collections-controls"><label for="collections-action-dialog-add-to-existing" class="action-panel-label"> Choose a collection: </label><select id="collections-action-dialog-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="collections_button" data-ga-action="select_collection" data-ga-label="($('.collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"></select><div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br><a href="#">Please try again</a></div></div></div><div class="action-panel-actions"><button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="collections_button" data-ga-action="click" data-ga-label="add"> Add </button><button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="collections_button" data-ga-action="click" data-ga-label="cancel"> Cancel </button></div></form></div></div></div></div><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button><div class="display-options" 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of systematic reviews" tabindex="0" aria-controls="full-view-journal" aria-expanded="false" aria-label="Toggle dropdown menu for journal The Cochrane database of systematic reviews" data-pinger-ignore> Cochrane Database Syst Rev </button><div id="full-view-journal" class="journal-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for journal The Cochrane database of systematic reviews"><div class="title">Actions</div><div class="content"><ul class="journal-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D&sort=date&sort_order=desc" data-href="/?term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_journal_name_link&journal_abbrev=Cochrane Database Syst Rev" data-ga-category="search" data-ga-action="journal_link" data-ga-label="Cochrane Database Syst Rev"> Search in PubMed </a></li><li><a class="search-in-nlm-catalog-link dropdown-block-link" ref ="linksrc=search_in_nlm_catalog_link" href="https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Cochrane+Database+Syst+Rev%22%5BTitle+Abbreviation%5D" data-ga-category="search_catalog" data-ga-action="journal_link" data-ga-label="Cochrane Database Syst Rev"> Search in NLM Catalog </a></li><li><a class="add-to-search-link dropdown-block-link" ref ="linksrc=add_to_search_link" role="button" data-search-term='"Cochrane Database Syst Rev"[jour]' data-ga-category="search" data-ga-action="add_to_search" data-ga-label='"Cochrane Database Syst Rev"[jour]' href="#"> Add to Search </a></li></ul></div></div></div><span class="period">. </span><span class="cit">2023 Oct 11;10(10):CD007026.</span> </div> <span class="citation-doi"> doi: 10.1002/14651858.CD007026.pub7. </span> </div> <h1 class="heading-title"> Cerebrolysin for acute ischaemic stroke </h1> <div class="inline-authors"> <div class="authors"> <div class="authors-list"> <span class="authors-list-item "><a class="full-name" href="/?term=Ziganshina+LE&cauthor_id=37818733" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Liliya Eugenevna Ziganshina">Liliya Eugenevna Ziganshina</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Centre for Knowledge Translation, Federal State Budgetary Educational Institution of Continuing Professional Education "Russian Medical Academy of Continuing Professional Education", The Ministry of Health of the Russian Federation (RMANPO), Moscow, Russian Federation." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Pharmacology, Kazan State Medical University (KSMU), The Ministry of Health of the Russian Federation, Kazan, Russian Federation." href="#full-view-affiliation-2" ref="linksrc=author_aff"> 2 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of General and Clinical Pharmacology, RUDN University named after Patrice Lumumba, Moscow, Russian Federation." href="#full-view-affiliation-3" ref="linksrc=author_aff"> 3 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Abakumova+T&cauthor_id=37818733" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Tatyana Abakumova">Tatyana Abakumova</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Biochemistry, Biotechnology and Pharmacology, Kazan (Volga region) Federal University, Kazan, Russian Federation." href="#full-view-affiliation-4" ref="linksrc=author_aff"> 4 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Nurkhametova+D&cauthor_id=37818733" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Dilyara Nurkhametova">Dilyara Nurkhametova</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Centre for Knowledge Translation, Federal State Budgetary Educational Institution of Continuing Professional Education "Russian Medical Academy of Continuing Professional Education", The Ministry of Health of the Russian Federation (RMANPO), Moscow, Russian Federation." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Ivanchenko+K&cauthor_id=37818733" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Kristina Ivanchenko">Kristina Ivanchenko</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Palliative Care, St. Alexis Hospital, Moscow, Russian Federation." href="#full-view-affiliation-5" ref="linksrc=author_aff"> 5 </a></sup></span> </div> </div> </div> <div class="short-article-details"> Affiliations <button class="more-details" id="toggle-authors" data-alt-text="Collapse" aria-controls="expanded-authors" aria-expanded="false" data-pinger-ignore data-fetch-url="/37818733/long-authors/" data-id-prefix=""> <span class="title"> Expand </span> </button> </div> <div class="extended-article-details" id="expanded-authors" aria-hidden="true"> <div class="expanded-authors" id="full-view-expanded-authors"> <div class="affiliations"> <h3 class="title"> Affiliations </h3> <ul class="item-list"> <li data-affiliation-id="full-view-affiliation-1" id="full-view-affiliation-1" ><sup class="key">1</sup> Centre for Knowledge Translation, Federal State Budgetary Educational Institution of Continuing Professional Education "Russian Medical Academy of Continuing Professional Education", The Ministry of Health of the Russian Federation (RMANPO), Moscow, Russian Federation.</li> <li data-affiliation-id="full-view-affiliation-2" id="full-view-affiliation-2" ><sup class="key">2</sup> Department of Pharmacology, Kazan State Medical University (KSMU), The Ministry of Health of the Russian Federation, Kazan, Russian Federation.</li> <li data-affiliation-id="full-view-affiliation-3" id="full-view-affiliation-3" ><sup class="key">3</sup> Department of General and Clinical Pharmacology, RUDN University named after Patrice Lumumba, Moscow, Russian Federation.</li> <li data-affiliation-id="full-view-affiliation-4" id="full-view-affiliation-4" ><sup class="key">4</sup> Department of Biochemistry, Biotechnology and Pharmacology, Kazan (Volga region) Federal University, Kazan, Russian Federation.</li> <li data-affiliation-id="full-view-affiliation-5" id="full-view-affiliation-5" ><sup class="key">5</sup> Palliative Care, St. Alexis Hospital, Moscow, Russian Federation.</li> </ul> </div> </div> </div> <ul class="identifiers" id="full-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">37818733</strong> </span> </li> <li> <span class="identifier pmc"> <span class="id-label"> PMCID: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=PMC10565895&id_type=PMC" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC10565895/" data-ga-category="full_text" data-ga-action="PMCID" > PMC10565895 </a> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.1002/14651858.CD007026.pub7&id_type=DOI" href="https://doi.org/10.1002/14651858.cd007026.pub7" data-ga-category="full_text" data-ga-action="DOI" > 10.1002/14651858.CD007026.pub7 </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> <div class="short-view" id="short-view-heading"> <div class="publication-type" >Review</div> <h1 class="heading-title"> Cerebrolysin for acute ischaemic stroke </h1> <div class="short-citation"> <span class="authors-list"> <span class="authors-list-item "><span class="full-name">Liliya Eugenevna Ziganshina</span><span class="citation-separator"> et al.</span></span> </span> <span class="citation-journal"> Cochrane Database Syst Rev<span class="citation-separator">.</span> </span> <span class="date"> <time class="citation-year" datetime="2023">2023</time><span class="citation-separator">.</span> </span> </div> <div class="more-article-details-section with-display-settings"> <button class="more-article-details" id="toggle-article-details" data-alt-text="Hide details" ref="linksrc=toggle_article_details" aria-controls="full-article-details" aria-expanded="false" data-fetch-url="/37818733/long-authors/" data-id-prefix=""> <span class="title">Show details</span> </button> <div class="display-options" data-format-key="format" data-default-format-value="abstract" data-current-format-value="abstract" role="region"> <button class="trigger usa-button" title="Change format" data-ga-category="display_options" data-ga-action="display_options_dialog"> <span class="button-label">Display options</span> </button> <div class="dropdown" hidden> <div class="title"> Display options </div> <div class="content"> <div class="format-container"> <span class="option-label"> Format </span> <select name="format" data-initial-value="abstract" aria-label="Display format" id="mobile-display-format"> <option value="abstract">Abstract</option> <option value="pubmed">PubMed</option> <option value="pmid">PMID</option> </select> </div> </div> </div> </div> </div> <div class="extended-article-details" id="full-article-details" aria-hidden="true"> <div class="article-citation"> <div class="article-source"> <div class="journal-actions dropdown-block"><button id="short-view-journal-trigger" 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data-ga-label="Cochrane Database Syst Rev"> Search in PubMed </a></li><li><a class="search-in-nlm-catalog-link dropdown-block-link" ref ="linksrc=search_in_nlm_catalog_link" href="https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Cochrane+Database+Syst+Rev%22%5BTitle+Abbreviation%5D" data-ga-category="search_catalog" data-ga-action="journal_link" data-ga-label="Cochrane Database Syst Rev"> Search in NLM Catalog </a></li><li><a class="add-to-search-link dropdown-block-link" ref ="linksrc=add_to_search_link" role="button" data-search-term='"Cochrane Database Syst Rev"[jour]' data-ga-category="search" data-ga-action="add_to_search" data-ga-label='"Cochrane Database Syst Rev"[jour]' href="#"> Add to Search </a></li></ul></div></div></div><span class="period">. </span><span class="cit">2023 Oct 11;10(10):CD007026.</span> </div> <span class="citation-doi"> doi: 10.1002/14651858.CD007026.pub7. </span> </div> <div class="expanded-authors" id="short-view-expanded-authors"> <div class="authors"> <h3 class="title"> Authors </h3> <div class="authors-list"> <span class="authors-list-item "><a class="full-name" href="/?term=Ziganshina+LE&cauthor_id=37818733" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Liliya Eugenevna Ziganshina">Liliya Eugenevna Ziganshina</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Centre for Knowledge Translation, Federal State Budgetary Educational Institution of Continuing Professional Education "Russian Medical Academy of Continuing Professional Education", The Ministry of Health of the Russian Federation (RMANPO), Moscow, Russian Federation." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Pharmacology, Kazan State Medical University (KSMU), The Ministry of Health of the Russian Federation, Kazan, Russian Federation." href="#short-view-affiliation-2" ref="linksrc=author_aff"> 2 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of General and Clinical Pharmacology, RUDN University named after Patrice Lumumba, Moscow, Russian Federation." href="#short-view-affiliation-3" ref="linksrc=author_aff"> 3 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Abakumova+T&cauthor_id=37818733" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Tatyana Abakumova">Tatyana Abakumova</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Biochemistry, Biotechnology and Pharmacology, Kazan (Volga region) Federal University, Kazan, Russian Federation." href="#short-view-affiliation-4" ref="linksrc=author_aff"> 4 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Nurkhametova+D&cauthor_id=37818733" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Dilyara Nurkhametova">Dilyara Nurkhametova</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Centre for Knowledge Translation, Federal State Budgetary Educational Institution of Continuing Professional Education "Russian Medical Academy of Continuing Professional Education", The Ministry of Health of the Russian Federation (RMANPO), Moscow, Russian Federation." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Ivanchenko+K&cauthor_id=37818733" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Kristina Ivanchenko">Kristina Ivanchenko</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Palliative Care, St. Alexis Hospital, Moscow, Russian Federation." href="#short-view-affiliation-5" ref="linksrc=author_aff"> 5 </a></sup></span> </div> </div> <div class="affiliations"> <h3 class="title"> Affiliations </h3> <ul class="item-list"> <li data-affiliation-id="short-view-affiliation-1" id="short-view-affiliation-1" ><sup class="key">1</sup> Centre for Knowledge Translation, Federal State Budgetary Educational Institution of Continuing Professional Education "Russian Medical Academy of Continuing Professional Education", The Ministry of Health of the Russian Federation (RMANPO), Moscow, Russian Federation.</li> <li data-affiliation-id="short-view-affiliation-2" id="short-view-affiliation-2" ><sup class="key">2</sup> Department of Pharmacology, Kazan State Medical University (KSMU), The Ministry of Health of the Russian Federation, Kazan, Russian Federation.</li> <li data-affiliation-id="short-view-affiliation-3" id="short-view-affiliation-3" ><sup class="key">3</sup> Department of General and Clinical Pharmacology, RUDN University named after Patrice Lumumba, Moscow, Russian Federation.</li> <li data-affiliation-id="short-view-affiliation-4" id="short-view-affiliation-4" ><sup class="key">4</sup> Department of Biochemistry, Biotechnology and Pharmacology, Kazan (Volga region) Federal University, Kazan, Russian Federation.</li> <li data-affiliation-id="short-view-affiliation-5" id="short-view-affiliation-5" ><sup class="key">5</sup> Palliative Care, St. Alexis Hospital, Moscow, Russian Federation.</li> </ul> </div> </div> <ul class="identifiers" id="short-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">37818733</strong> </span> </li> <li> <span class="identifier pmc"> <span class="id-label"> PMCID: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=PMC10565895&id_type=PMC" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC10565895/" data-ga-category="full_text" data-ga-action="PMCID" > PMC10565895 </a> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.1002/14651858.CD007026.pub7&id_type=DOI" href="https://doi.org/10.1002/14651858.cd007026.pub7" data-ga-category="full_text" data-ga-action="DOI" > 10.1002/14651858.CD007026.pub7 </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> </div> </header> <div class="actions-buttons inline"><div class="inner-wrap"><button class="full-text-links-button full-text-links-dialog-trigger" title="Open dialog with full text links" ref="linksrc=full_text_links"> Full text links </button><button class="citation-button citation-dialog-trigger" aria-label="Open dialog with citation text in different styles" data-ga-category="save_share" data-ga-action="cite" data-ga-label="open" data-all-citations-url="/37818733/citations/" data-citation-style="nlm" data-pubmed-format-link="/37818733/export/"><span class="button-label">Cite</span></button><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button><div class="display-options" data-format-key="format" data-default-format-value="abstract" data-current-format-value="abstract" role="region"><button class="trigger usa-button" title="Change format" data-ga-category="display_options" data-ga-action="display_options_dialog"><span class="button-label">Display options</span></button><div class="dropdown" hidden><div class="title"> Display options </div><div class="content"><div class="format-container"><span class="option-label"> Format </span><select name="format" data-initial-value="abstract" aria-label="Display format" id="inline-actions-display-format"><option value="abstract">Abstract</option><option value="pubmed">PubMed</option><option value="pmid">PMID</option></select></div></div></div></div></div></div> <div class="abstract" id="abstract"> <h2 class="title"> Abstract </h2> <div class="abstract-content selected" id="eng-abstract"> <p> <strong class="sub-title"> Background: </strong> Cerebrolysin is a mixture of low-molecular-weight peptides and amino acids derived from porcine brain, which has potential neuroprotective properties. It is widely used in the treatment of acute ischaemic stroke in Russia, Eastern Europe, China, and other Asian and post-Soviet countries. This is an update of a review first published in 2010 and last updated in 2020. </p> <p> <strong class="sub-title"> Objectives: </strong> To assess the benefits and harms of Cerebrolysin or Cerebrolysin-like agents for treating acute ischaemic stroke. </p> <p> <strong class="sub-title"> Search methods: </strong> We searched the Cochrane Stroke Trials Register, CENTRAL, MEDLINE, Embase, Web of Science Core Collection, with Science Citation Index, and LILACS in May 2022 and a number of Russian databases in June 2022. We also searched reference lists, ongoing trials registers, and conference proceedings. </p> <p> <strong class="sub-title"> Selection criteria: </strong> Randomised controlled trials (RCTs) comparing Cerebrolysin or Cerebrolysin-like agents started within 48 hours of stroke onset and continued for any length of time, with placebo or no treatment in people with acute ischaemic stroke. </p> <p> <strong class="sub-title"> Data collection and analysis: </strong> Three review authors independently applied the inclusion criteria, assessed trial quality and risk of bias, extracted data, and applied GRADE criteria to the evidence. </p> <p> <strong class="sub-title"> Main results: </strong> Seven RCTs (1773 participants) met the inclusion criteria of the review. In this update we added one RCT of Cerebrolysin-like agent Cortexin, which contributed 272 participants. We used the same approach for risk of bias assessment that was re-evaluated for the previous update: we added consideration of the public availability of study protocols and reported outcomes to the selective outcome reporting judgement, through identification, examination, and evaluation of study protocols. For the Cerebrolysin studies, we judged the risk of bias for selective outcome reporting to be unclear across all studies; for blinding of participants and personnel to be low in three studies and unclear in the remaining four; and for blinding of outcome assessors to be low in three studies and unclear in four studies. We judged the risk of bias for generation of allocation sequence to be low in one study and unclear in the remaining six studies; for allocation concealment to be low in one study and unclear in six studies; and for incomplete outcome data to be low in three studies and high in the remaining four studies. The manufacturer of Cerebrolysin supported three multicentre studies, either totally, or by providing Cerebrolysin and placebo, randomisation codes, research grants, or statisticians. We judged two studies to be at high risk of other bias and the remaining five studies to be at unclear risk of other bias. We judged the study of Cortexin to be at low risk of bias for incomplete outcome data and at unclear risk of bias for all other domains. All-cause death: Cerebrolysin or Cortexin probably result in little to no difference in all-cause death (risk ratio (RR) 0.96, 95% confidence interval (CI) 0.65 to 1.41; 6 trials, 1689 participants; moderate-certainty evidence). None of the included studies reported on poor functional outcome, defined as death or dependence at the end of the follow-up period, early death (within two weeks of stroke onset), quality of life, or time to restoration of capacity for work. Only one study clearly reported on the cause of death: cerebral infarct (four in the Cerebrolysin and two in the placebo group), heart failure (two in the Cerebrolysin and one in the placebo group), pulmonary embolism (two in the placebo group), and pneumonia (one in the placebo group). Non-death attrition (secondary outcome): Cerebrolysin or similar peptide mixtures may result in little to no difference in non-death attrition, but the evidence is very uncertain, with a considerable level of heterogeneity (RR 0.72, 95% CI 0.38 to 1.39; 6 trials, 1689 participants; very low-certainty evidence). Serious adverse events (SAEs): Cerebrolysin probably results in little to no difference in the total number of people with SAEs (RR 1.16, 95% CI 0.81 to 1.66; 3 trials, 1335 participants; moderate-certainty evidence). This comprised fatal SAEs (RR 0.90, 95% CI 0.59 to 1.38; 3 trials, 1335 participants; moderate-certainty evidence) and an increase in the total number of people with non-fatal SAEs (RR 2.39, 95% CI 1.10 to 5.23; 3 trials, 1335 participants; moderate-certainty evidence). In the subgroup of dosing schedule 30 mL for 10 days (cumulative dose 300 mL), the increase was more prominent (RR 2.87, 95% CI 1.24 to 6.69; 2 trials, 1189 participants). Total number of people with adverse events: Cerebrolysin or similar peptide mixtures may result in little to no difference in the total number of people with adverse events (RR 1.03, 95% CI 0.92 to 1.14; 4 trials, 1607 participants; low-certainty evidence). </p> <p> <strong class="sub-title"> Authors' conclusions: </strong> Moderate-certainty evidence indicates that Cerebrolysin or Cerebrolysin-like peptide mixtures derived from cattle brain probably have no beneficial effect on preventing all-cause death in acute ischaemic stroke. Moderate-certainty evidence suggests that Cerebrolysin probably has no beneficial effect on the total number of people with serious adverse events. Moderate-certainty evidence also indicates a potential increase in non-fatal serious adverse events with Cerebrolysin use. </p> </div> </div> <p class="copyright" id="copyright"> Copyright © 2023 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. </p> <p class="disclaimer" id="disclaimer"> <a href="/disclaimer/" target="_blank" ga_category="literature_resources" ga_action="disclaimer_link" ga_label="under_abstract">PubMed Disclaimer</a> </p> <div class="conflict-of-interest" id="conflict-of-interest"> <h2 class="title"> Conflict of interest statement </h2> <div class="statement"> <p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">LEZ: is a Cochrane director (Cochrane Russia). She was not involved in the editorial process.</p> <p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">TRA: none known.</p> <p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">DN: none known.</p> <p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">KI: none known.</p> </div> </div> <div class="figures" id="figures"> <h2 class="title"> Figures </h2> <div class="figures-list" id="slides-container" itemscope itemtype="http://schema.org/ImageGallery"> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="0" data-label-slug="1"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3268/10565895/9afd68382cce/tCD007026-FIG-01.jpg" itemprop="contentUrl" aria-describedby="figure-caption-0" role="button" data-image-width="100" data-image-height="100" data-image-alt="1" data-pmc-id="PMC10565895" data-figure-id="CD007026-fig-0001"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-0" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3268/10565895/f38220fa16da/tCD007026-FIG-01.gif" alt="1" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="100"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="100"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> 1 </p> </strong> <div class="figure-caption-contents"><p> Study flow diagram </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> 1 </p> </strong> <div class="figure-caption-contents"><p> Study flow diagram </p></div> </div> <figcaption id="figure-caption-0" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> 1 </strong> <div class="figure-caption-contents">Study flow diagram</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="1" data-label-slug="2"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3268/10565895/70f1c7c6b2be/tCD007026-FIG-02.jpg" itemprop="contentUrl" aria-describedby="figure-caption-1" role="button" data-image-width="100" data-image-height="100" data-image-alt="2" data-pmc-id="PMC10565895" data-figure-id="CD007026-fig-0002"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-1" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3268/10565895/7171185470fb/tCD007026-FIG-02.gif" alt="2" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="100"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="100"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> 2 </p> </strong> <div class="figure-caption-contents"><p> Risk of bias summary: review authors'… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> 2 </p> </strong> <div class="figure-caption-contents"><p> Risk of bias summary: review authors' judgements about each risk of bias item for… </p></div> </div> <figcaption id="figure-caption-1" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> 2 </strong> <div class="figure-caption-contents">Risk of bias summary: review authors' judgements about each risk of bias item for each included study.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="2" data-label-slug="11"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3268/10565895/f9ef3dc69ce2/tCD007026-CMP-001.01.jpg" itemprop="contentUrl" aria-describedby="figure-caption-2" role="button" data-image-width="100" data-image-height="100" data-image-alt="1.1" data-pmc-id="PMC10565895" data-figure-id="CD007026-fig-0003"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-2" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3268/10565895/7878e92d61a4/tCD007026-CMP-001.01.gif" alt="1.1" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="100"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="100"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> 1.1. Analysis </p> </strong> <div class="figure-caption-contents"><p> Comparison 1: Cerebrolysin or Cortexin… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> 1.1. Analysis </p> </strong> <div class="figure-caption-contents"><p> Comparison 1: Cerebrolysin or Cortexin versus placebo, Outcome 1: All‐cause death </p></div> </div> <figcaption id="figure-caption-2" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> 1.1. Analysis </strong> <div class="figure-caption-contents">Comparison 1: Cerebrolysin or Cortexin versus placebo, Outcome 1: All‐cause death</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="3" data-label-slug="12"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3268/10565895/5fb702171e66/tCD007026-CMP-001.02.jpg" itemprop="contentUrl" aria-describedby="figure-caption-3" role="button" data-image-width="100" data-image-height="100" data-image-alt="1.2" data-pmc-id="PMC10565895" data-figure-id="CD007026-fig-0004"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-3" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3268/10565895/c15a9c69db1c/tCD007026-CMP-001.02.gif" alt="1.2" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="100"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="100"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> 1.2. Analysis </p> </strong> <div class="figure-caption-contents"><p> Comparison 1: Cerebrolysin or Cortexin… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> 1.2. Analysis </p> </strong> <div class="figure-caption-contents"><p> Comparison 1: Cerebrolysin or Cortexin versus placebo, Outcome 2: Non‐death attrition </p></div> </div> <figcaption id="figure-caption-3" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> 1.2. Analysis </strong> <div class="figure-caption-contents">Comparison 1: Cerebrolysin or Cortexin versus placebo, Outcome 2: Non‐death attrition</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="4" data-label-slug="13"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3268/10565895/3475a67fb9b2/tCD007026-CMP-001.03.jpg" itemprop="contentUrl" aria-describedby="figure-caption-4" role="button" data-image-width="100" data-image-height="100" data-image-alt="1.3" data-pmc-id="PMC10565895" data-figure-id="CD007026-fig-0005"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-4" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3268/10565895/90465a1b1f15/tCD007026-CMP-001.03.gif" alt="1.3" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="100"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="100"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> 1.3. Analysis </p> </strong> <div class="figure-caption-contents"><p> Comparison 1: Cerebrolysin or Cortexin… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> 1.3. Analysis </p> </strong> <div class="figure-caption-contents"><p> Comparison 1: Cerebrolysin or Cortexin versus placebo, Outcome 3: Total number of people… </p></div> </div> <figcaption id="figure-caption-4" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> 1.3. Analysis </strong> <div class="figure-caption-contents">Comparison 1: Cerebrolysin or Cortexin versus placebo, Outcome 3: Total number of people with SAEs</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="5" data-label-slug="14"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3268/10565895/3adf848de0f9/tCD007026-CMP-001.04.jpg" itemprop="contentUrl" aria-describedby="figure-caption-5" role="button" data-image-width="100" data-image-height="100" data-image-alt="1.4" data-pmc-id="PMC10565895" data-figure-id="CD007026-fig-0006"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-5" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3268/10565895/611037f3f677/tCD007026-CMP-001.04.gif" alt="1.4" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="100"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="100"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> 1.4. Analysis </p> </strong> <div class="figure-caption-contents"><p> Comparison 1: Cerebrolysin or Cortexin… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> 1.4. Analysis </p> </strong> <div class="figure-caption-contents"><p> Comparison 1: Cerebrolysin or Cortexin versus placebo, Outcome 4: Total number of people… </p></div> </div> <figcaption id="figure-caption-5" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> 1.4. Analysis </strong> <div class="figure-caption-contents">Comparison 1: Cerebrolysin or Cortexin versus placebo, Outcome 4: Total number of people with fatal SAEs</div> </figcaption> </figure> <figure class="figure-item tail" itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="6" data-label-slug="15"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3268/10565895/173683fee810/tCD007026-CMP-001.05.jpg" itemprop="contentUrl" aria-describedby="figure-caption-6" role="button" data-image-width="100" data-image-height="100" data-image-alt="1.5" data-pmc-id="PMC10565895" data-figure-id="CD007026-fig-0007"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-6" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3268/10565895/8144f3ffdc42/tCD007026-CMP-001.05.gif" alt="1.5" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="100"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="100"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> 1.5. Analysis </p> </strong> <div class="figure-caption-contents"><p> Comparison 1: Cerebrolysin or Cortexin… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> 1.5. Analysis </p> </strong> <div class="figure-caption-contents"><p> Comparison 1: Cerebrolysin or Cortexin versus placebo, Outcome 5: Total number of people… </p></div> </div> <figcaption id="figure-caption-6" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> 1.5. Analysis </strong> <div class="figure-caption-contents">Comparison 1: Cerebrolysin or Cortexin versus placebo, Outcome 5: Total number of people with non‐fatal SAEs</div> </figcaption> </figure> <figure class="figure-item tail" itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="7" data-label-slug="16"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3268/10565895/43dccf60516c/tCD007026-CMP-001.06.jpg" itemprop="contentUrl" aria-describedby="figure-caption-7" role="button" data-image-width="100" data-image-height="100" data-image-alt="1.6" data-pmc-id="PMC10565895" data-figure-id="CD007026-fig-0008"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-7" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3268/10565895/ecc77276983e/tCD007026-CMP-001.06.gif" alt="1.6" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="100"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="100"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> 1.6. Analysis </p> </strong> <div class="figure-caption-contents"><p> Comparison 1: Cerebrolysin or Cortexin… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> 1.6. Analysis </p> </strong> <div class="figure-caption-contents"><p> Comparison 1: Cerebrolysin or Cortexin versus placebo, Outcome 6: Total number of people… </p></div> </div> <figcaption id="figure-caption-7" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> 1.6. Analysis </strong> <div class="figure-caption-contents">Comparison 1: Cerebrolysin or Cortexin versus placebo, Outcome 6: Total number of people with adverse events</div> </figcaption> </figure> <figure class="figure-item tail" itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="8" data-label-slug="21"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3268/10565895/3eb2a48198d2/tCD007026-CMP-002.01.jpg" itemprop="contentUrl" aria-describedby="figure-caption-8" role="button" data-image-width="100" data-image-height="100" data-image-alt="2.1" data-pmc-id="PMC10565895" data-figure-id="CD007026-fig-0009"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-8" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3268/10565895/49aa3a952f6d/tCD007026-CMP-002.01.gif" alt="2.1" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="100"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="100"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> 2.1. Analysis </p> </strong> <div class="figure-caption-contents"><p> Comparison 2: Sensitivity analyses: Cerebrolysin… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> 2.1. Analysis </p> </strong> <div class="figure-caption-contents"><p> Comparison 2: Sensitivity analyses: Cerebrolysin or Cortexin versus placebo, Outcome 1: All‐cause death.… </p></div> </div> <figcaption id="figure-caption-8" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> 2.1. Analysis </strong> <div class="figure-caption-contents">Comparison 2: Sensitivity analyses: Cerebrolysin or Cortexin versus placebo, Outcome 1: All‐cause death. Sensitivity 1. Best‐case</div> </figcaption> </figure> <figure class="figure-item tail" itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="9" data-label-slug="22"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3268/10565895/cdf1557fd118/tCD007026-CMP-002.02.jpg" itemprop="contentUrl" aria-describedby="figure-caption-9" role="button" data-image-width="100" data-image-height="100" data-image-alt="2.2" data-pmc-id="PMC10565895" data-figure-id="CD007026-fig-0010"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-9" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3268/10565895/41a32e7af08a/tCD007026-CMP-002.02.gif" alt="2.2" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="100"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="100"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> 2.2. Analysis </p> </strong> <div class="figure-caption-contents"><p> Comparison 2: Sensitivity analyses: Cerebrolysin… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> 2.2. Analysis </p> </strong> <div class="figure-caption-contents"><p> Comparison 2: Sensitivity analyses: Cerebrolysin or Cortexin versus placebo, Outcome 2: All‐cause death.… </p></div> </div> <figcaption id="figure-caption-9" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> 2.2. Analysis </strong> <div class="figure-caption-contents">Comparison 2: Sensitivity analyses: Cerebrolysin or Cortexin versus placebo, Outcome 2: All‐cause death. Sensitivity 2. Worst‐case</div> </figcaption> </figure> <figure class="figure-item tail" itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="10" data-label-slug="23"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3268/10565895/b2f60bfbd997/tCD007026-CMP-002.03.jpg" itemprop="contentUrl" aria-describedby="figure-caption-10" role="button" data-image-width="100" data-image-height="100" data-image-alt="2.3" data-pmc-id="PMC10565895" data-figure-id="CD007026-fig-0011"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-10" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3268/10565895/14f02992b1d9/tCD007026-CMP-002.03.gif" alt="2.3" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="100"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="100"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> 2.3. Analysis </p> </strong> <div class="figure-caption-contents"><p> Comparison 2: Sensitivity analyses: Cerebrolysin… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> 2.3. Analysis </p> </strong> <div class="figure-caption-contents"><p> Comparison 2: Sensitivity analyses: Cerebrolysin or Cortexin versus placebo, Outcome 3: All‐cause death.… </p></div> </div> <figcaption id="figure-caption-10" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> 2.3. Analysis </strong> <div class="figure-caption-contents">Comparison 2: Sensitivity analyses: Cerebrolysin or Cortexin versus placebo, Outcome 3: All‐cause death. Sensitivity 3. Complete case (missing data excluded)</div> </figcaption> </figure> <figure class="figure-item tail" itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="11" data-label-slug="24"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3268/10565895/fcebd382ab16/tCD007026-CMP-002.04.jpg" itemprop="contentUrl" aria-describedby="figure-caption-11" role="button" data-image-width="100" data-image-height="100" data-image-alt="2.4" data-pmc-id="PMC10565895" data-figure-id="CD007026-fig-0012"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-11" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3268/10565895/524561af2f7f/tCD007026-CMP-002.04.gif" alt="2.4" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="100"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="100"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> 2.4. Analysis </p> </strong> <div class="figure-caption-contents"><p> Comparison 2: Sensitivity analyses: Cerebrolysin… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> 2.4. Analysis </p> </strong> <div class="figure-caption-contents"><p> Comparison 2: Sensitivity analyses: Cerebrolysin or Cortexin versus placebo, Outcome 4: All‐cause death.… </p></div> </div> <figcaption id="figure-caption-11" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> 2.4. Analysis </strong> <div class="figure-caption-contents">Comparison 2: Sensitivity analyses: Cerebrolysin or Cortexin versus placebo, Outcome 4: All‐cause death. Sensitivity 4. Risk of bias</div> </figcaption> </figure> </div> <div class="see-all actions-bar"> <button class="show-more" aria-controls="slides-container" data-ga-category="figure" data-ga-action="show_all"> All figures (12) </button> </div>  <div class="pswp figures-dialog" id="figures-dialog" tabindex="-1" role="dialog" aria-hidden="true" data-image-gallery-uid="article-figures" aria-label="Figures Dialog">  <div class="pswp__bg"></div>  <div class="pswp__scroll-wrap">  <div class="pswp__container"> <div class="pswp__item"></div> <div class="pswp__item"></div> <div class="pswp__item"></div> </div>  <div class="pswp__ui pswp__ui--hidden"> <div class="pswp__top-bar">  <div class="pswp__counter"></div> <button class="pswp__button pswp__button--close" title="Close (Esc)"></button> <button class="pswp__button pswp__button--share" title="Share"></button> <button class="pswp__button pswp__button--fs" title="Toggle fullscreen"></button> <button class="pswp__button pswp__button--zoom" title="Zoom 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Cerebrolysin effects on neurological outcomes and cerebral blood flow in acute ischemic stroke. Neuropsychiatric Disease and Treatment 2014;10:2299-306. [DOI: 10.2147/NDT.S75304] - <a class="reference-link" href="https://doi.org/10.2147/ndt.s75304" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="10.2147/NDT.S75304" > DOI </a> - <a class="reference-link" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4263193/" ref="linksrc=references_link&ordinalpos=2" data-ga-category="reference" data-ga-action="PMC4263193" > PMC </a> - <a class="reference-link" href="/25516711/" ref="linksrc=references_link&ordinalpos=3" data-ga-category="reference" data-ga-action="25516711" > PubMed </a> </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Nazarbaghi S, Amiri Nikpoor M. Acute stroke management efficiency of cerebrolysin in treatment of patients with acute ischemic stroke. International Journal of Stroke 2014;9 Suppl 3:91-2. </li> </ol> </li> </ol> </div> <div class="refs-list"> <h5 class="refs-list-title">CASTA 2012 {published data only}</h5> <ol id="top-references-list-3" class="references-list"> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Bornstein NM. CASTA - the background for the study and protocol design. International Journal of Stroke 2010;5 Suppl 2:50. </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Brainin M, Heiss WD, Bornstein N, Tuomilehto J, Hong Z. CASTA - results of a double-blind, placebo-controlled, randomized trial with cerebrolysin on patients with acute ischaemic stroke in Asia. Cerebrovascular Diseases 2012;33 Suppl 2:459-60. </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Heiss WD, Brainin M, Bornstein N, Zhen H. Cerebrolysin in patients with acute ischemic stroke - the CASTA study. International Journal of Stroke 2010;5 Suppl 2:71. </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Heiss WD, Brainin M, Bornstein NM, Tuomilehto J, Hong Z, Cerebrolysin Acute Stroke Treatment in Asia (CASTA) Investigators. Cerebrolysin in patients with acute ischemic stroke in Asia: results of a double-blind, placebo-controlled randomized trial. Stroke 2012;43(3):630-6. - <a class="reference-link" href="/22282884/" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="22282884" > PubMed </a> </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Hong Z, Moessler H, Bornstein N, Brainin M, Heiss W-D, CASTA Investigators. A double-blind, placebo-controlled, randomized trial to evaluate the safety and efficacy of cerebrolysin in patients with acute ischaemic stroke in Asia - CASTA. International Journal of Stroke 2009;4(5):406-12. - <a class="reference-link" href="/19765131/" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="19765131" > PubMed </a> </li> </ol> </li> </ol> <div class="actions-bar"> <button class="show-all" ref="linksrc=show_all_references_link" aria-controls="top-references-list-3" data-next-page-url="/37818733/references/" data-ga-category="reference" data-ga-action="show_more" > Show all 6 references </button> </div> </div> <div class="refs-list"> <h5 class="refs-list-title">CERE‐LYSE‐1 2012 {published data only}</h5> <ol id="top-references-list-4" class="references-list"> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Lang W, Stadler CH, Poljakovic Z, Fleet D, Lyse Study Group. A prospective, randomized, placebo-controlled, double-blind trial about safety and efficacy combined treatment with alteplase (rt-PA) and cerebrolysin in acute ischaemic hemispheric stroke. International Journal of Stroke 2012;8(2):95-104. - <a class="reference-link" href="/23009193/" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="23009193" > PubMed </a> </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> NCT00840671. Combined treatment with alteplase (Rt-PA) and cerebrolysin® in acute ischemic hemispheric stroke (CERE-LYSE). <a class="external-link-urlize" href="http://clinicaltrials.gov/show/NCT00840671" rel="nofollow noopener" target="_blank">clinicaltrials.gov/show/NCT00840671</a> (first received 10 February 2009). </li> </ol> </li> </ol> </div> <div class="refs-list"> <h5 class="refs-list-title">Cortexin‐Shamalov 2014 {published data only}17707356<ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="https://www.elibrary.ru/item.asp?id=17707356">https://www.elibrary.ru/item.asp?id=17707356</ext-link></h5> <ol id="top-references-list-5" class="references-list"> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Aliferova VM, Dadasheva MN, Doronin BM, Kovalenko AV, Lokshtanova TM, Martynov MYu, et al. Clinical efficacy and pharmacoeconomic characteristics of the neuroprotection with low doses of cortexin in the treatment of acute ischemic stroke [Клиническая эффективность и фармакоэкономические характеристики нейропротекции низкими дозами кортексина в терапии острого ишемического инсульта]. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova [Korsakov Journal of Neurology and Psychiatry] 2014;4:41‑6. [ELIBRARY ID: 21538285] [<a class="external-link-urlize" href="http://ELIBRARY.RU" rel="nofollow noopener" target="_blank">ELIBRARY.RU</a>: <a href="https://elibrary.ru/item.asp?id=21538285" rel="noopener nofollow" target="_blank" title="External link: https://elibrary.ru/item.asp?id=21538285">https://elibrary.ru/item.asp?id=21538285</a>] - <a class="reference-link" href="/24874316/" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="24874316" > PubMed </a> </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Stakhovskaya LV, Meshkova KS, Dadasheva MN, Chefranova JYu, Titova LP, Lokshtanova TM, et al. Results of multicenter randomize prospective double-blind placebo-controlled study of the safety and efficacy of cortexin in acute and subacute periods of hemispheric ischemic stroke [Многоцентровое рандомизированное проспективное двойное слепое плацебо контролируемое исследование безопасности и эффективности кортексина в остром и раннем восстановительном периоде полушарного ишемического инсульта]. Vestnik Rossiiskoy Voenno-Meditsinskoy Academii [Bulletin of the Russian Military Medical Academy] 2012;1(37):238-44. [ELIBRARY ID: 17707356] [<a class="external-link-urlize" href="http://ELIBRARY.RU" rel="nofollow noopener" target="_blank">ELIBRARY.RU</a>: <a href="https://www.elibrary.ru/item.asp?id=17707356" rel="noopener nofollow" target="_blank" title="External link: https://www.elibrary.ru/item.asp?id=17707356">https://www.elibrary.ru/item.asp?id=17707356</a>] </li> </ol> </li> </ol> </div> <div class="refs-list"> <h5 class="refs-list-title">Ladurner 2005 {published data only}</h5> <ol id="top-references-list-6" class="references-list"> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Ladurner G, Gmeinbauer R, Moessler H. Cerebrolysin in acute ischaemic stroke: a randomized, placebo-controlled trial with a neuroprotective agent. Cerebrovascular Diseases 2001;11(4):75. </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Ladurner G, Kalvach P, Moessler H, Cerebrolysin Study Group. Neuroprotective treatment with cerebrolysin in patients with acute stroke: a randomised controlled trial. Journal of Neural Transmission 2005;112(3):415-28. - <a class="reference-link" href="/15583955/" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="15583955" > PubMed </a> </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Ladurner G. Neuroprotection in acute ischaemic stroke. Stroke 2001;32 Suppl 1:323. </li> </ol> </li> </ol> </div> <div class="refs-list"> <h5 class="refs-list-title">Skvortsova 2004 {published data only}</h5> <ol id="top-references-list-7" class="references-list"> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Skvortsova VI, Shamalov NA, Stakhovskaya LV, Gubsky LV, Tikhonova IV, Smichkov AS. Cerebrolysin in acute ischaemic stroke: results of randomised, double blind, placebo-controlled study. Cerebrovascular Diseases 2005;19 Suppl 2:76. </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Skvortsova VI, Stakhovskaia LV, Gubskii LV, Shamalov NA, Tikhonova IV, Smychkov AS. A randomized, double-blind, placebo-controlled study of Cerebrolysin safety and efficacy in the treatment of acute ischemic stroke. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova [Korsakov Journal of Neurology and Psychiatry] 2004;Suppl 11:51-5. - <a class="reference-link" href="/15559222/" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="15559222" > PubMed </a> </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Skvortsova VI, Stakhovskaya LV, Gubsky LV, Shamalov NA, Tikhonova IV, Smychkov AS. Evaluation of safety and efficacy of cerebrolysin for treating acute ischaemic stroke [Issledovaniye bezopasnosti i effektivnosti tserebrolizina dlya lecheniya ostrogo ishemicheskogo insul’ta]. Рецепт [Prescription] 2007;5(55):94-8. </li> </ol> </li> </ol> </div> <div class="refs-list"> <h5 class="refs-list-title">Xue 2016 {published data only}</h5> <ol id="top-references-list-8" class="references-list"> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> NCT02149875. Dl-3-n-butylphthalide and cerebrolysin treatment in acute ischemic stroke. <a class="external-link-urlize" href="http://clinicaltrials.gov/show/NCT02149875" rel="nofollow noopener" target="_blank">clinicaltrials.gov/show/NCT02149875</a> (first received 29 May 2014). </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Xue LX, Zhang T, Zhao YW, Geng Z, Chen JJ, Chen H. Efficacy and safety comparison of DL-3-n-butylphthalide and cerebrolysin: effects on neurological and behavioral outcomes in acute ischemic stroke. Experimental and Therapeutic Medicine 2016;11(5):2015-20. - <a class="reference-link" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4840538/" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="PMC4840538" > PMC </a> - <a class="reference-link" href="/27168844/" ref="linksrc=references_link&ordinalpos=2" data-ga-category="reference" data-ga-action="27168844" > PubMed </a> </li> </ol> </li> </ol> </div> </div> <div class="refs-list"> <h4 class="refs-list-title">References to studies excluded from this review</h4> <div class="refs-list"> <h5 class="refs-list-title">Belova 2018 {published data only}</h5> <ol id="top-references-list-10" class="references-list"> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Belova LA, Mashin VV, Abramova VV, Slastyon EYu, Belov DV. Efficacy of cortexin in the acute period of hemispheric ischemic stroke [Эффективность кортексина в остром периоде полушарного ишемического инсульта]. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova [Korsakov Journal of Neurology and Psychiatry] 2018;7:30-4. [DOI: ] - <a class="reference-link" href="/30132453/" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="30132453" > PubMed </a> </li> </ol> </li> </ol> </div> <div class="refs-list"> <h5 class="refs-list-title">Bogolepova 2019 {published data only}</h5> <ol id="top-references-list-11" class="references-list"> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Bogolepova AN. Possibilities of neurotrophic therapy in early recovery after stroke [Возможности нейротрофической терапии в раннем восстановлении после инсульта]. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova [Korsakov Journal of Neurology and Psychiatry] 2019;119(8):84-9. [DOI: ] - <a class="reference-link" href="/31825367/" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="31825367" > PubMed </a> </li> </ol> </li> </ol> </div> <div class="refs-list"> <h5 class="refs-list-title">CEREC‐Stroke {published data only}</h5> <ol id="top-references-list-12" class="references-list"> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> ISRCTN15233803. Evaluation of efficacy and safety of Cerebrolysin as add-on therapy in patients with acute stroke after failed recanalisation therapy. <a class="external-link-urlize" href="https://www.isrctn.com/ISRCTN15233803" rel="nofollow noopener" target="_blank">https://www.isrctn.com/ISRCTN15233803</a> (first received 25 May 2020). [DOI: ] </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Poljakovic Z, Supe S, Ljevak J, Starcevic K, Peric I, Blazevic N, et al. Efficacy and safety of Cerebrolysin after futile recanalisation therapy in patients with severe stroke. Clinical Neurology and Neurosurgery 2021;207:106767. [DOI: 10.1016/j.clineuro.2021.106767] [PMID: ] - <a class="reference-link" href="https://doi.org/10.1016/j.clineuro.2021.106767" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="10.1016/j.clineuro.2021.106767" > DOI </a> - <a class="reference-link" href="/34214867/" ref="linksrc=references_link&ordinalpos=2" data-ga-category="reference" data-ga-action="34214867" > PubMed </a> </li> </ol> </li> </ol> </div> <div class="refs-list"> <h5 class="refs-list-title">Gharagozli 2017 {published data only}</h5> <ol id="top-references-list-13" class="references-list"> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Gharagozli K, Harandi AA, Houshmand S, Akbari N, Muresanu DF, Vester J, et al. Efficacy and safety of Cerebrolysin treatment in early recovery after acute ischemic stroke: a randomized, placebo-controlled, double-blinded, multicenter clinical trial. Journal of Medicine and Life 2017;10(3):153-60. - <a class="reference-link" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC5652261/" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="PMC5652261" > PMC </a> - <a class="reference-link" href="/29075343/" ref="linksrc=references_link&ordinalpos=2" data-ga-category="reference" data-ga-action="29075343" > PubMed </a> </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> IRCT138803272042N1. The efficacy of cerebrolysin in the treatment of acute ischemic stroke. <a class="external-link-urlize" href="http://en.irct.ir/trial/1663" rel="nofollow noopener" target="_blank">en.irct.ir/trial/1663</a> (first received 29 August 2009). </li> </ol> </li> </ol> </div> <div class="refs-list"> <h5 class="refs-list-title">Kurenkova 2014 {published data only}</h5> <ol id="top-references-list-14" class="references-list"> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Kurenkova NA, Filatova MS, Popov DV, Makarova LD, Makhankov OV. Efficiency of Cortexin in early rehabilitation of patients with ischemic stroke [Эффективность Кортексина при ранней реабилитации больных с ишемическим инсультом]. Russkii Meditsinskii Zhurnal [Russian Medical Journal] 2014 ;10:748. [RMJ: <a href="https://www.rmj.ru/articles/klinicheskaya_farmakologiya/Effektivnosty_Korteksina_pri_ranney_reabilitacii_bolynyh_s_ishemicheskim_insulytom/" rel="noopener nofollow" target="_blank" title="External link: https://www.rmj.ru/articles/klinicheskaya_farmakologiya/Effektivnosty_Korteksina_pri_ranney_reabilitacii_bolynyh_s_ishemicheskim_insulytom/">https://www.rmj.ru/articles/klinicheskaya_farmakologiya/Effektivnosty_Ko...</a>] </li> </ol> </li> </ol> </div> <div class="refs-list"> <h5 class="refs-list-title">NCT04904341 {published data only}</h5> <ol id="top-references-list-15" class="references-list"> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> NCT04904341. Efficacy of Cerebrolysin treatment as an add-on therapy to mechanical thrombectomy in acute ischemic stroke. <a class="external-link-urlize" href="https://classic.clinicaltrials.gov/ct2/show/NCT04904341" rel="nofollow noopener" target="_blank">https://classic.clinicaltrials.gov/ct2/show/NCT04904341</a> (first received 27 May 2021). [<a class="external-link-urlize" href="http://CLINICALTRIALS.GOV" rel="nofollow noopener" target="_blank">CLINICALTRIALS.GOV</a> IDENTIFIER: NCT04904341] </li> </ol> </li> </ol> </div> <div class="refs-list"> <h5 class="refs-list-title">Slyusar 2021 {published data only}</h5> <ol id="top-references-list-16" class="references-list"> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Slyusar O, Maximov I, Babaskina L, Lobuteva L. Ineffective drugs: Cerebrolysin and piracetam. Research Journal of Pharmacy and Technology 2021;14:2643-8. [DOI: 10.52711/0974-360X.2021.00466] - <a class="reference-link" href="https://doi.org/10.52711/0974-360x.2021.00466" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="10.52711/0974-360X.2021.00466" > DOI </a> </li> </ol> </li> </ol> </div> </div> <div class="refs-list"> <h4 class="refs-list-title">References to ongoing studies</h4> <div class="refs-list"> <h5 class="refs-list-title">CEREHETIS {published data only}</h5> <ol id="top-references-list-18" class="references-list"> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> ISRCTN87656744. Cerebrolysin to prevent intracranial bleeding after intravenous thrombolysis (blood clot) in patients with ischemic stroke. <a class="external-link-urlize" href="https://www.isrctn.com/ISRCTN87656744" rel="nofollow noopener" target="_blank">https://www.isrctn.com/ISRCTN87656744</a> (first received 16 February 2021). [DOI: ] </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Kalinin M, Khasanova D. Cerebrolysin as an early add-on to reperfusion therapy: risk of hemorrhagic transformation after ischemic stroke (CEREHETIS). A prospective, randomized, active control, multicenter pilot study. European Stroke Journal 2021;6(1 Suppl):35. [DOI: 10.1177/23969873211034932] - <a class="reference-link" href="https://doi.org/10.1177/23969873211034932" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="10.1177/23969873211034932" > DOI </a> - <a class="reference-link" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC10041692/" ref="linksrc=references_link&ordinalpos=2" data-ga-category="reference" data-ga-action="PMC10041692" > PMC </a> - <a class="reference-link" href="/36973684/" ref="linksrc=references_link&ordinalpos=3" data-ga-category="reference" data-ga-action="36973684" > PubMed </a> </li> </ol> </li> </ol> </div> <div class="refs-list"> <h5 class="refs-list-title">CERE‐REHA‐RU/01 {published data only}</h5> <ol id="top-references-list-19" class="references-list"> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> CERE-REHA-RU/01. Double-blind placebo-controlled multi-centre randomised parallel group clinical study of phase IV on effectiveness of adding cerebrolysin to standard rehabilitation complex interventions in patients with ischaemic stroke. <a class="external-link-urlize" href="http://grls.rosminzdrav.ru/CIPermissionMini.aspx?CIStatementGUID=70440249-c5c0-4928-979f-aac87894585a&CIPermGUID=7F9E91B4-F074-4BA4-9D79-7C730A0F32A0" rel="nofollow noopener" target="_blank">grls.rosminzdrav.ru/CIPermissionMini.aspx?CIStatementGUID=70440249-c5c0-...</a> (first received 19 January 2015). </li> </ol> </li> </ol> </div> <div class="refs-list"> <h5 class="refs-list-title">GP20011‐P4‐32 {published data only}</h5> <ol id="top-references-list-20" class="references-list"> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> GP20011-P4-32. Multicenter, double-blind, placebo-controlled, randomized, in two parallel groups study of the efficacy of Cortexin®, 10 mg, manufactured by GEROPHARM LLC, Russia, in patients in the acute period of ischemic stroke [Многоцентровое двойное слепое плацебо контролируемое рандомизированное в двух параллельных группах исследование эффективности лекарственного препарата Кортексин®, 10 мг, производства ООО «ГЕРОФАРМ», Россия, у пациентов в остром периоде ишемического инсульта]. <a class="external-link-urlize" href="https://grls.rosminzdrav.ru/CIPermissionMini.aspx?CIStatementGUID=71c142c1-fcc2-45da-8dba-b48971284d39&CIPermGUID=F7D8A60C-8575-44FB-B29D-C2AA06D32082" rel="nofollow noopener" target="_blank">https://grls.rosminzdrav.ru/CIPermissionMini.aspx?CIStatementGUID=71c142...</a> (first received 29 August 2019). </li> </ol> </li> </ol> </div> <div class="refs-list"> <h5 class="refs-list-title">GP20011‐P4‐36 {published data only}</h5> <ol id="top-references-list-21" class="references-list"> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> GP20011-P4-36. Multicenter, double-blind, randomized, controlled, parallel study of the therapeutic equivalence of intramuscular and intravenous forms of administration of the drug Cortexin®, 10 mg, produced by GEROPHARM LLC, Russia, in relation to the degree of functional recovery in patients in the acute period of ischemic stroke [Многоцентровое двойное слепое рандомизированное контролируемое параллельное исследование терапевтической эквивалентности внутримышечной и внутривенной форм введения лекарственного препарата Кортексин®, 10 мг, производства ООО «ГЕРОФАРМ», Россия, в отношении степени функционального восстановления у пациентов в остром периоде ишемического инсульта]. <a class="external-link-urlize" href="https://grls.rosminzdrav.ru/CIPermissionMini.aspx?CIStatementGUID=5ee0440d-d6d0-4502-8df8-89ecb8e0ca3e&CIPermGUID=E8356E01-ECFC-4A83-9A06-2FF1D29EB37B" rel="nofollow noopener" target="_blank">https://grls.rosminzdrav.ru/CIPermissionMini.aspx?CIStatementGUID=5ee044...</a> (first received 2 December 2021). </li> </ol> </li> </ol> </div> <div class="refs-list"> <h5 class="refs-list-title">IRCT201406169014N36 {published and unpublished data}</h5> <ol id="top-references-list-22" class="references-list"> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> IRCT201406169014N36. The effect of cerebrolysin versus placebo on improvement of patients with acute ischemic stroke: a double blinded randomized clinical trial. <a class="external-link-urlize" href="http://en.irct.ir/trial/9475" rel="nofollow noopener" target="_blank">en.irct.ir/trial/9475</a> (first received 23 March 2014). </li> </ol> </li> </ol> </div> <div class="refs-list"> <h5 class="refs-list-title">ISRCTN54581790 (ESCAS) {published data only}</h5> <ol id="top-references-list-23" class="references-list"> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> ISRCTN54581790. Efficacy and safety of Cerebrolysin in the treatment of aphasia after acute ischemic stroke (ESCAS). <a class="external-link-urlize" href="https://www.isrctn.com/ISRCTN54581790" rel="nofollow noopener" target="_blank">https://www.isrctn.com/ISRCTN54581790</a> (first received 29 April 2020). [DOI: ] </li> </ol> </li> </ol> </div> <div class="refs-list"> <h5 class="refs-list-title">ISRCTN88122184 (CODEC) {published data only}</h5> <ol id="top-references-list-24" class="references-list"> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> ISRCTN88122184. Can treatment with Cerebrolysin improve recovery after acute ischemic stroke? <a class="external-link-urlize" href="https://www.isrctn.com/ISRCTN88122184" rel="nofollow noopener" target="_blank">https://www.isrctn.com/ISRCTN88122184</a> (first received 29 April 2020). [DOI: ] </li> </ol> </li> </ol> </div> <div class="refs-list"> <h5 class="refs-list-title">NCT05124353 {published data only}</h5> <ol id="top-references-list-25" class="references-list"> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> NCT05124353. Evaluation of the effect of early administration of neuroprotective drug (Cerebrolysin) on the outcome of patients with acute ischemic stroke undergoing endovascular therapy. <a class="external-link-urlize" href="https://clinicaltrials.gov/ct2/show/record/NCT05124353" rel="nofollow noopener" target="_blank">https://clinicaltrials.gov/ct2/show/record/NCT05124353</a> (first received 17 November 2021). </li> </ol> </li> </ol> </div> </div> <div class="refs-list"> <h4 class="refs-list-title">Additional references</h4> <div class="refs-list"> <h5 class="refs-list-title">AHA 2019</h5> <ol id="top-references-list-27" class="references-list"> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Benjamin EJ, Muntner P, Alonso A, Bittencourt MS, Callaway CW, Carson AP, et al. Heart disease and stroke disease statistics - 2019 update: a report from the American Heart Association. Circulation 2019;139:e1-473. 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Art. No: CD007026. [DOI: 10.1002/14651858.CD007026.pub6] - <a class="reference-link" href="https://doi.org/10.1002/14651858.cd007026.pub6" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="10.1002/14651858.CD007026.pub6" > DOI </a> - <a class="reference-link" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7387239/" ref="linksrc=references_link&ordinalpos=2" data-ga-category="reference" data-ga-action="PMC7387239" > PMC </a> - <a class="reference-link" href="/32662068/" ref="linksrc=references_link&ordinalpos=3" data-ga-category="reference" data-ga-action="32662068" > PubMed </a> </li> </ol> </li> </ol> </div> </div> </div> </div> <div id="publication-types" class="publication-types keywords-section"> <h2 class="title"> Publication types </h2> <ul class="keywords-list"><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Systematic Review" tabindex="0" 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data-href="/?term=%22Ischemic+Stroke%2Fchemically+induced%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Ischemic Stroke/chemically induced"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Ischemic Stroke* / chemically induced"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Ischemic+Stroke" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Ischemic Stroke* / chemically induced"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Ischemic Stroke/chemically induced"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Ischemic Stroke/chemically induced"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions 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therapy"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Ischemic+Stroke" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Ischemic Stroke* / drug therapy"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Ischemic Stroke/drug therapy"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Ischemic Stroke/drug therapy"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Peptides" tabindex="0" aria-controls="keyword-actions-mesh-terms-5" aria-expanded="false" data-pinger-ignore> Peptides </button><div id="keyword-actions-mesh-terms-5" 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ref="linksrc=search_in_pubmed_keyword_link&mesh="Stroke/chemically induced"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Stroke* / chemically induced"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Stroke" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Stroke* / chemically induced"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Stroke/chemically induced"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Stroke/chemically induced"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Stroke* / drug therapy" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-7" aria-expanded="false" data-pinger-ignore> Stroke* / drug therapy </button><div id="keyword-actions-mesh-terms-major-7" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Stroke* / drug therapy"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Stroke%2Fdrug+therapy%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Stroke%2Fdrug+therapy%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Stroke/drug therapy"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Stroke* / drug therapy"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Stroke" data-ga-category="search_mesh" 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href="/?term=%22Swine%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Swine%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Swine"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Swine"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Swine" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Swine"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Swine"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Swine"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li></ul> </div> <div id="substances" class="substances keywords-section"> <h2 class="title"> Substances </h2> <ul class="keywords-list"><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword cerebrolysin" tabindex="0" aria-controls="keyword-actions-substances-0" aria-expanded="false" data-pinger-ignore> cerebrolysin </button><div id="keyword-actions-substances-0" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword cerebrolysin"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22cerebrolysin%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22cerebrolysin%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="cerebrolysin"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="cerebrolysin"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" 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class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Amino+Acids%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Amino+Acids%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Amino Acids"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Amino Acids"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Amino+Acids%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="Amino Acids"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Amino Acids"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Amino Acids"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Peptides" tabindex="0" aria-controls="keyword-actions-substances-2" aria-expanded="false" data-pinger-ignore> Peptides </button><div id="keyword-actions-substances-2" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Peptides"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Peptides%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Peptides%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Peptides"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Peptides"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" 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