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Rozhkova</a>, <a href="https://publications.waset.org/abstracts/search?q=O.%20Rozhkova"> O. Rozhkova</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Harlova"> A. Harlova</a>, <a href="https://publications.waset.org/abstracts/search?q=V.%20Lasukov"> V. Lasukov</a> </p> <p class="card-text"><strong>Abstract:</strong></p> For optimal unbiased filter as mean-square and in the case of functioning anomalous noises in the observation memory channel, we have proved insensitivity of filter to inaccurate knowledge of the anomalous noise intensity matrix and its equivalence to truncated filter plotted only by non anomalous components of an observation vector. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=mathematical%20expectation" title="mathematical expectation">mathematical expectation</a>, <a href="https://publications.waset.org/abstracts/search?q=filtration" title=" filtration"> filtration</a>, <a href="https://publications.waset.org/abstracts/search?q=anomalous%20noise" title=" anomalous noise"> anomalous noise</a>, <a href="https://publications.waset.org/abstracts/search?q=memory" title=" memory"> memory</a> </p> <a href="https://publications.waset.org/abstracts/28833/analysis-of-filtering-in-stochastic-systems-on-continuous-time-memory-observations-in-the-presence-of-anomalous-noises" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/28833.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">365</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">316</span> Probing Anomalous WW γ and WWZ Couplings with Polarized Electron Beam at the LHeC and FCC-Ep Collider</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=I.%20Turk%20Cakir">I. Turk Cakir</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Senol"> A. Senol</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20T.%20Tasci"> A. T. Tasci</a>, <a href="https://publications.waset.org/abstracts/search?q=O.%20Cakir"> O. Cakir</a> </p> <p class="card-text"><strong>Abstract:</strong></p> We study the anomalous WWγ and WWZ couplings by calculating total cross sections of the ep→νqγX and ep→νqZX processes at the LHeC with electron beam energy Ee=140 GeV and the proton beam energy Ep=7 TeV, and at the FCC-ep collider with the polarized electron beam energy Ee=80 GeV and the proton beam energy Ep=50 TeV. At the LHeC with electron beam polarization, we obtain the results for the difference of upper and lower bounds as (0.975, 0.118) and (0.285, 0.009) for the anomalous (Δκγ,λγ) and (Δκz,λz) couplings, respectively. As for FCC-ep collider, these bounds are obtained as (1.101,0.065) and (0.320,0.002) at an integrated luminosity of Lint=100 fb-1. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=anomalous%20couplings" title="anomalous couplings">anomalous couplings</a>, <a href="https://publications.waset.org/abstracts/search?q=future%20circular%20collider" title=" future circular collider"> future circular collider</a>, <a href="https://publications.waset.org/abstracts/search?q=large%20hadron%20electron%20collider" title=" large hadron electron collider"> large hadron electron collider</a>, <a href="https://publications.waset.org/abstracts/search?q=W-boson%20and%20Z-boson" title=" W-boson and Z-boson"> W-boson and Z-boson</a> </p> <a href="https://publications.waset.org/abstracts/17408/probing-anomalous-ww-gh-and-wwz-couplings-with-polarized-electron-beam-at-the-lhec-and-fcc-ep-collider" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/17408.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">389</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">315</span> Synthesis of Filtering in Stochastic Systems on Continuous-Time Memory Observations in the Presence of Anomalous Noises</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=S.%20Rozhkova">S. Rozhkova</a>, <a href="https://publications.waset.org/abstracts/search?q=O.%20Rozhkova"> O. Rozhkova</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Harlova"> A. Harlova</a>, <a href="https://publications.waset.org/abstracts/search?q=V.%20Lasukov"> V. Lasukov</a> </p> <p class="card-text"><strong>Abstract:</strong></p> We have conducted the optimal synthesis of root-mean-squared objective filter to estimate the state vector in the case if within the observation channel with memory the anomalous noises with unknown mathematical expectation are complement in the function of the regular noises. The synthesis has been carried out for linear stochastic systems of continuous-time. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=mathematical%20expectation" title="mathematical expectation">mathematical expectation</a>, <a href="https://publications.waset.org/abstracts/search?q=filtration" title=" filtration"> filtration</a>, <a href="https://publications.waset.org/abstracts/search?q=anomalous%20noise" title=" anomalous noise"> anomalous noise</a>, <a href="https://publications.waset.org/abstracts/search?q=memory" title=" memory"> memory</a> </p> <a href="https://publications.waset.org/abstracts/28832/synthesis-of-filtering-in-stochastic-systems-on-continuous-time-memory-observations-in-the-presence-of-anomalous-noises" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/28832.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">251</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">314</span> WT1 Expression in Ovarian Malignant Surface Epithelial Tumors</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mahmoodreza%20Tahamtan">Mahmoodreza Tahamtan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Malignant surface epithelial ovarian tumors(SEOT) account for approximately 90% of primary ovarian cancer. We evaluate the immunohistochemical expression of WT1 protein among different histologic subtypes of SEOT. Immunohistochemistry for WT1 was done on 35 serous cystadenocarcinomas, 9 borderline serous tumors. A tumor was considered negative if < 1% of tumor cells were stained.Positive reactions were graded as follows:1+,1%-24%; 2+,25%-49%; 3+,50%-74%; 4+,75%-100%. Of the 35 cases of ovarian serous cystadenocarcinoma 30(85.7%)were diffusely positive(3+,4+),4 showed reactivity of < 50% of the tumor cells(1+,2+) and one were negative. All 9 borderline serous tumors showed immunoreactivity with WT1. WT1 is a good marker to distinguish primary ovarian serous carcinomas from other surface epithelial tumors. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=WT1" title="WT1">WT1</a>, <a href="https://publications.waset.org/abstracts/search?q=ovary" title=" ovary"> ovary</a>, <a href="https://publications.waset.org/abstracts/search?q=malignant" title=" malignant"> malignant</a>, <a href="https://publications.waset.org/abstracts/search?q=epithelial%20tumors" title=" epithelial tumors"> epithelial tumors</a> </p> <a href="https://publications.waset.org/abstracts/160272/wt1-expression-in-ovarian-malignant-surface-epithelial-tumors" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/160272.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">109</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">313</span> Role of Human Epididymis Protein 4 as a Biomarker in the Diagnosis of Ovarian Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Amar%20Ranjan">Amar Ranjan</a>, <a href="https://publications.waset.org/abstracts/search?q=Julieana%20Durai"> Julieana Durai</a>, <a href="https://publications.waset.org/abstracts/search?q=Pranay%20Tanwar"> Pranay Tanwar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background &Introduction: Ovarian cancer is one of the most common malignant tumor in the female. 70% of the cases of ovarian cancer are diagnosed at an advanced stage. The five-year survival rate associated with ovarian cancer is less than 30%. The early diagnosis of ovarian cancer becomes a key factor in improving the survival rate of patients. Presently, CAl25 (carbohydrate antigen125) is used for the diagnosis and therapeutic monitoring of ovarian cancer, but its sensitivity and specificity is not ideal. The introduction of HE4, human epididymis protein 4 has attracted much attention. HE4 has a sensitivity and specificity of 72.9% and 95% for differentiating between benign and malignant adnexal masses, which is better than CA125 detection. Methods: Serum HE4 and CA -125 were estimated using the chemiluminescence method. Our cases were 40 epithelial ovarian cancer, 9 benign ovarian tumor, 29 benign gynaecological diseases and 13 healthy individuals. This group include healthy woman those who have undergoing family planning and menopause-related medical consultations and they are negative for ovarian mass. Optimal cut off values for HE4 and CA125 were 55.89pmol/L and 40.25U/L respectively (determined by statistical analysis). Results: The level of HE4 was raised in all ovarian cancer patients (n=40) whereas CA125 levels were normal in 6/40 ovarian cancer patients, which were the cases of OC confirmed by histopathology. There is a significant decrease in the level of HE4 with comparison to CA125 in benign ovarian tumor cases. Both the levels of HE4 and CA125 were raised in the nonovarian cancer group, which includes cancer of endometrium and cervix. In the healthy group, HE4 was normal in all patients except in one case of the rudimentary horn, and the reason for this raised HE4 level is due to the incomplete development of uterus whereas CA125 was raised in 3 cases. Conclusions: Findings showed that the serum level of HE4 is an important indicator in the diagnosis of ovarian cancer, and it also distinguishes between benign and malignant pelvic masses. However, a combination of HE4 and CA125 panel will be extremely valuable in improving the diagnostic efficiency of ovarian cancer. These findings of our study need to be validated in the larger cohort of patients. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=human%20epididymis%20protein%204" title="human epididymis protein 4">human epididymis protein 4</a>, <a href="https://publications.waset.org/abstracts/search?q=ovarian%20cancer" title=" ovarian cancer"> ovarian cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=diagnosis" title=" diagnosis"> diagnosis</a>, <a href="https://publications.waset.org/abstracts/search?q=benign%20lesions" title=" benign lesions"> benign lesions</a> </p> <a href="https://publications.waset.org/abstracts/108113/role-of-human-epididymis-protein-4-as-a-biomarker-in-the-diagnosis-of-ovarian-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/108113.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">136</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">312</span> The Relationship between Size of Normal and Cystic Bovine Ovarian Follicles with Follicular Fluid Levels of Nitric Oxide and Estradiol</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hamidreza%20Khodaei">Hamidreza Khodaei</a>, <a href="https://publications.waset.org/abstracts/search?q=Behnaz%20Mahdavi"> Behnaz Mahdavi</a>, <a href="https://publications.waset.org/abstracts/search?q=Leila%20Karshenas"> Leila Karshenas</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Nitric oxide (NO) is a small fast acting neurotransmitter, which is synthesized From L-arginine by nitric oxide synthase. Studies show that NO affects a wide range of reproductive functions. Steroidal hormones synthesis, LH surge during ovulation, follicular growth and ovulation are all affected by NO. Therefore, the objective of this study was to evaluate the relationship between NO and estradiol (E2) production in ovarian follicles and cysts in bovines. Two experiment groups were formed and serum and follicular fluid levels Of NO and estradiol (E2) was measured. In the first group, follicular fluids were obtained from 30 slaughtered cows. Follicles were divided into three groups according to follicular diameter: Small follicles, <5 mm, medium-sized follicles, 5 to 10 mm, and large follicles, >10 mm. 30 follicles were randomly selected within each group. Blood samples were obtained via jugular vein. NO concentrations in blood and ovarian follicular fluids were measured by Griess reaction method and radio-immunoassay respectively. In the second group: 12 cows in follicular phase and with cystic follicles were selected and a cystic follicle was obtained from each. NO and E2 levels were measured as done for the first experiment group. The data were analyzed by SAS software using ANOVA and Duncan’s test. NO concentrations of follicular fluids from large follicles were significantly higher than those of the medium and small-sized ones. There were significant differences in the concentrations of nitrite and nitrate (Stable metabolites of NO) between large and cystic follicles, with extremely low NO and high E2 levels in cystic follicles (p<0.01).The results suggest that paracrine effects of NO may play an important role in the control of ovarian follicle growth and development of cystic follicles in bovines. It seems that NO dictates its effects through inhibition of ovarian steroidal synthesis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=nitric%20oxide" title="nitric oxide">nitric oxide</a>, <a href="https://publications.waset.org/abstracts/search?q=estradiol" title=" estradiol"> estradiol</a>, <a href="https://publications.waset.org/abstracts/search?q=cystic%20follicle" title=" cystic follicle"> cystic follicle</a>, <a href="https://publications.waset.org/abstracts/search?q=cow" title=" cow"> cow</a>, <a href="https://publications.waset.org/abstracts/search?q=oogenesis" title=" oogenesis"> oogenesis</a>, <a href="https://publications.waset.org/abstracts/search?q=oocyte%20maturation" title=" oocyte maturation"> oocyte maturation</a>, <a href="https://publications.waset.org/abstracts/search?q=follicular%20fluid" title=" follicular fluid"> follicular fluid</a> </p> <a href="https://publications.waset.org/abstracts/12654/the-relationship-between-size-of-normal-and-cystic-bovine-ovarian-follicles-with-follicular-fluid-levels-of-nitric-oxide-and-estradiol" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/12654.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">239</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">311</span> Endometriosis-Associated Ovarian Cancer: Clinical and Pathological Pattern</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=I.%20Ramalho">I. Ramalho</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Campos"> S. Campos</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Dias"> M. Dias</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Endometriosis may play a role in the pathogenesis of ovarian cancer (OC), however, the risk and prognosis have not been well established. The association between these two pathologies could have an important impact on prevention and early diagnosis of OC. Objective: To analyze the prevalence of endometriosis associated ovarian cancer and related clinical, epidemiological and histopathological issues. Design: We conducted a retrospective case series analysis of patients diagnosed with endometriosis and ovarian cancer in the Gynecology Department of Coimbra University Hospital Center since 2006 to 2015. Methods: We collected data from women diagnosed with ovarian cancer, with anatomopathology records reporting findings of endometriosis in ovarian cancer patients. Patients were retrieved from the pathological records and appropriate medical records were retrospectively reviewed. Statistical analysis was performed using SPSS 22.0. Results: Histological evidence of endometriosis was found in 17 out of 261 patients diagnosed with ovarian cancer (OC) (6.51%). The most usual symptoms were pelvic pain, abdominal distension, asthenia, ascites, weight loss and nausea. Mean age at diagnosis was 61.2 ± 15.1, 41-86 years old, 33.3% were pre-menopausal patients and cancer stage distribution was predominantly stage I (31.3%) and stage III (56.3%). OC occurred unilaterally in 14 patients and 2 patients were diagnosed with a synchronous ovarian and endometrial cancer. Regarding histological type, 10 OC were classified as clear cell carcinoma (CCC), 4 endometrioid carcinomas (EC) and 3 mixed type (clear cell and endometrioid). Four ovarian carcinomas presumably arose from endometriomas: 3 CCC and 1 EC. Conclusions: In accordance with previous studies, clear cell was the most common pathological type in endometriotic patients, followed by endometrioid carcinomas, and two rare synchronous ovarian and endometrial carcinomas were registered. Although endometriosis association to OC is uncommon, endometriosis should be managed with special care in order to early diagnosis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=endometriosis" title="endometriosis">endometriosis</a>, <a href="https://publications.waset.org/abstracts/search?q=histology" title=" histology"> histology</a>, <a href="https://publications.waset.org/abstracts/search?q=observational%20study" title=" observational study"> observational study</a>, <a href="https://publications.waset.org/abstracts/search?q=ovarian%20cancer" title=" ovarian cancer"> ovarian cancer</a> </p> <a href="https://publications.waset.org/abstracts/71642/endometriosis-associated-ovarian-cancer-clinical-and-pathological-pattern" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/71642.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">234</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">310</span> FDX1, a Cuproptosis-Related Gene, Identified as a Potential Target for Human Ovarian Aging</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Li-Te%20Lin">Li-Te Lin</a>, <a href="https://publications.waset.org/abstracts/search?q=Chia-Jung%20Li"> Chia-Jung Li</a>, <a href="https://publications.waset.org/abstracts/search?q=Kuan-Hao%20Tsui"> Kuan-Hao Tsui</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Cuproptosis, a newly identified cell death mechanism, has attracted attention for its association with various diseases. However, the genetic interplay between cuproptosis and ovarian aging remains largely unexplored. This study aims to address this gap by analyzing datasets related to ovarian aging and cuproptosis. Spatial transcriptome analyses were conducted in the ovaries of both young and aged female mice to elucidate the role of FDX1. Comprehensive bioinformatics analyses, facilitated by R software, identified FDX1 as a potential cuproptosis-related gene with implications for ovarian aging. Clinical infertility biopsies were examined to validate these findings, showing consistent results in elderly infertile patients. Furthermore, pharmacogenomic analyses of ovarian cell lines explored the intricate association between FDX1 expression levels and sensitivity to specific small molecule drugs. Spatial transcriptome analyses revealed a significant reduction in FDX1 expression in aging ovaries, supported by consistent findings in biopsies from elderly infertile patients. Pharmacogenomic investigations indicated that modulating FDX1 could influence drug responses in ovarian-related therapies. This study pioneers the identification of FDX1 as a cuproptosis-related gene linked to ovarian aging. These findings not only contribute to understanding the mechanisms of ovarian aging but also position FDX1 as a potential diagnostic biomarker and therapeutic target. Further research may establish FDX1's pivotal role in advancing precision medicine and therapies for ovarian-related conditions. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cuproptosis" title="cuproptosis">cuproptosis</a>, <a href="https://publications.waset.org/abstracts/search?q=FDX1" title=" FDX1"> FDX1</a>, <a href="https://publications.waset.org/abstracts/search?q=ovarian%20aging" title=" ovarian aging"> ovarian aging</a>, <a href="https://publications.waset.org/abstracts/search?q=biomarker" title=" biomarker"> biomarker</a> </p> <a href="https://publications.waset.org/abstracts/186481/fdx1-a-cuproptosis-related-gene-identified-as-a-potential-target-for-human-ovarian-aging" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/186481.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">46</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">309</span> Effect of Unilateral Unoperated Ovarian Endometrioma on Responsiveness to Hyperstimulation </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Abdelmaguid%20Ramzy">Abdelmaguid Ramzy</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohamed%20Bahaa"> Mohamed Bahaa</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: The effects of ovarian endometrioma on fertility outcomes with IVF have been always related to poor outcomes. Objective: To evaluate the effect of unilateral unoperated ovarian endometrioma < 2cm on the number of developing follicles and compare them with the contralateral ovary as a control. Design: Retrospective case control study. Setting: KasrEl-Aini IVF center. Patient(s): We studied 32 women with unilateral endometrioma who underwent their first IVF cycle. Methods: 32 Patients aged between 20-35 years selected for IVF who were diagnosed with one unilateral endometrioma (diameter <2 cm) and who did not undergo previous ovarian surgery were retrospectively identified. The number of follicles > 17 mm during folliculometry on the day of HCG trigger in the ovary that contained endometrioma were compared with those from the contralateral ovary. They were all hyperstimulated using long protocol with (225-300 IU) gonadotrophins. Primary outcome: The number of follicles > 17 mm during folliculometry on the day of HCG trigger. Result(s): The mean ± SD age, Day 3 serum FSH and LH were 27± 3.7 years, 5.8 ± 1.6 IU/ml and 4.5 ± 1.7 IU/ml respectively. There was no significant difference in the number of follicles > 17 mm on the day of HCG trigger in the ovary that contained endometrioma (4.4 ±2.5) and in the opposite ovary (4.5 ± 2.8) (P= 0.48). Conclusion: The presence of ovarian endometrioma in a controlled ovarian hyperstimulation cycle for IVF treatment is not associated with a reduced number of follicles > 17 mm during folliculometry on the day of HCG trigger. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=endometrioma" title="endometrioma">endometrioma</a>, <a href="https://publications.waset.org/abstracts/search?q=folliculometry" title=" folliculometry"> folliculometry</a>, <a href="https://publications.waset.org/abstracts/search?q=hyperstimulation" title=" hyperstimulation"> hyperstimulation</a>, <a href="https://publications.waset.org/abstracts/search?q=fertility" title=" fertility"> fertility</a> </p> <a href="https://publications.waset.org/abstracts/8259/effect-of-unilateral-unoperated-ovarian-endometrioma-on-responsiveness-to-hyperstimulation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/8259.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">215</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">308</span> Expression of Hypoxia-Inducible Transmembrane Carbonic Anhydrases IX, Ca XII and Glut 1 in Ovarian Cancer </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=M.%20Sunitha">M. Sunitha</a>, <a href="https://publications.waset.org/abstracts/search?q=B.%20Nithyavani"> B. Nithyavani</a>, <a href="https://publications.waset.org/abstracts/search?q=Mathew%20Yohannan"> Mathew Yohannan</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Thiruvieni%20Balajji"> S. Thiruvieni Balajji</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20A.%20Rathi"> M. A. Rathi</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20Arul%20Raj"> C. Arul Raj</a>, <a href="https://publications.waset.org/abstracts/search?q=P.%20Ragavendran"> P. Ragavendran</a>, <a href="https://publications.waset.org/abstracts/search?q=V.%20K.%20Gopalkrishnan"> V. K. Gopalkrishnan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Establishment of an early and reliable biomarker for ovarian carcinogenesis whose expression can be monitored through noninvasive techniques will enable early diagnosis of cancer. Carbonic anhydrases (CA) isozymes IX and XII have been suggested to play a role in oncogenic processes. In von Hippel-Lindau (VHL)-defective tumors, the cell surface transmembrane carbonic anhydrase (CA) CA XI and CA XII genes are overexpressed because of the absence of pVHL. These enzymes are involved in causing a hypoxia condition, thereby providing an environment for metastasis. Aberrant expression of the facilitative glucose transporter GLUT I is found in a wide spectrum of epithelial malignancies. Studying the mRNA expression of CA IX, CA XII and Glut I isozymes in ovarian cancer cell lines (OAW-42 and PA-1) revealed the expression of these hypoxia genes. Immunohistochemical staining of carbonic anhydrases was also performed in 40 ovarian cancer tissues. CA IX and CA XII were expressed at 540 bp and 520 bp in OAW42, PA1 in ovarian cancer cell lines. GLUT-1 was expressed at 325bp in OAW 42, PA1 genes in ovarian cancer cell lines. Immunohistochemistry revealed high to moderate levels of expression of these enzymes. The immuostaining was seen predominantly on the cell surface membrane. The study concluded that these genes CA IX, CA XII and Glut I are expressed under hypoxic condition in tumor cells. From the present results expression of CA IX, XII and Glut I may represent potential targets in ovarian cancer therapy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ovarian%20cancer" title="ovarian cancer">ovarian cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=carbonic%20anhydrase%20IX" title=" carbonic anhydrase IX"> carbonic anhydrase IX</a>, <a href="https://publications.waset.org/abstracts/search?q=XII" title=" XII"> XII</a>, <a href="https://publications.waset.org/abstracts/search?q=Glut%20I" title=" Glut I"> Glut I</a>, <a href="https://publications.waset.org/abstracts/search?q=tumor%20markers" title=" tumor markers "> tumor markers </a> </p> <a href="https://publications.waset.org/abstracts/9998/expression-of-hypoxia-inducible-transmembrane-carbonic-anhydrases-ix-ca-xii-and-glut-1-in-ovarian-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/9998.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">372</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">307</span> Numerical Investigation of Blood Flow around a Leaflet Valve through a Perforating Vein</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Zohreh%20Sheidaei">Zohreh Sheidaei</a>, <a href="https://publications.waset.org/abstracts/search?q=Farhad%20Sadegh%20Moghanlou"> Farhad Sadegh Moghanlou</a>, <a href="https://publications.waset.org/abstracts/search?q=Rahim%20Vesal"> Rahim Vesal</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Diseases related to leg venous system are common worldwide. An incompetent vein with deformed wall and insufficient valves affects flow field of blood and disrupts the process of blood circulating system. Having enough knowledge about the flow field through veins will help find new ways to cure the related diseases. In the present study, blood flow around a leaflet valve of a perforating vein is investigated numerically by Finite Element Method. Flow behavior and vortexes, generated around the leaflet valves, are studied considering valve opening percentage. Obtained velocity and pressure fields show mechanical stresses on vein wall and these valves and consequently introduce the regions susceptible to deformation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=fluid%20flow" title="fluid flow">fluid flow</a>, <a href="https://publications.waset.org/abstracts/search?q=leaflet%20valve" title=" leaflet valve"> leaflet valve</a>, <a href="https://publications.waset.org/abstracts/search?q=numerical%20investigation" title=" numerical investigation"> numerical investigation</a>, <a href="https://publications.waset.org/abstracts/search?q=perforating%20vein" title=" perforating vein"> perforating vein</a> </p> <a href="https://publications.waset.org/abstracts/34659/numerical-investigation-of-blood-flow-around-a-leaflet-valve-through-a-perforating-vein" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/34659.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">416</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">306</span> A Review of Psychiatric Practices in Issues of Anomalous Experiences</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Prosper%20Kudzanai%20Mushauri">Prosper Kudzanai Mushauri</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In issues of anomalous experiences commonly referred to as madness or mental illness, attempts have been made to deal with it so that people manage to live their lives in a more functional way. It is in this stance that psychiatry has sort of portraying itself as seeking to ameliorate perturbations which individuals live with via nosological systems and use of medicine to anomalous experiences. It is from this hegemony that has led to the untold harm which people living with madness have endured from antique to contemporary life. The paper reflects via a literature review on the history of psychiatry and argues that it is akin to contemporary psychiatry to be involved in iatrogenic acts. As antique psychiatry meddled with gory issues of inhumanity, deceit and mass murders which some of those the contemporary psychiatry has not weaned itself from such diabolical acts. The objective of the paper is to suggest to psychiatry that it has not comported to the mores of psychological ethics. In doing this, the paper hopes that psychiatry will reflect and reform its curricular and praxis so that it comports to ethical standards in psychological science in ameliorating anomalous experiences. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=nosology" title="nosology">nosology</a>, <a href="https://publications.waset.org/abstracts/search?q=psychiatry" title=" psychiatry"> psychiatry</a>, <a href="https://publications.waset.org/abstracts/search?q=madness" title=" madness"> madness</a>, <a href="https://publications.waset.org/abstracts/search?q=diagnosis" title=" diagnosis"> diagnosis</a>, <a href="https://publications.waset.org/abstracts/search?q=eugenics" title=" eugenics"> eugenics</a> </p> <a href="https://publications.waset.org/abstracts/107317/a-review-of-psychiatric-practices-in-issues-of-anomalous-experiences" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/107317.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">168</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">305</span> Effects of New Anthraquinone Derivatives on Resistance Ovarian Cancer Cells and The Mechanism Investigation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hui-Hsin%20Huang">Hui-Hsin Huang</a>, <a href="https://publications.waset.org/abstracts/search?q=Sheng-Tung%20Huang"> Sheng-Tung Huang</a>, <a href="https://publications.waset.org/abstracts/search?q=Chi-Ming%20Lee"> Chi-Ming Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Chiao-Han%20Yen"> Chiao-Han Yen</a>, <a href="https://publications.waset.org/abstracts/search?q=Chun-Mao%20Lin"> Chun-Mao Lin</a> </p> <p class="card-text"><strong>Abstract:</strong></p> At initiation stage, there are no symptoms at initiation stage; however, at late stage, patients suffer symptoms as soon as ovarian cancer metastasis. Moreover, ovarian cancer cells are resistant to some anti-ovarian cancer drugs in clinical. Thus, it is very important to find an effective treatment for resistant ovarian cancer. Anthraquinone derivatives are able to induce DNA damage and lead to cell apoptosis, so several derivatives have been used for clinical application. Therefore, to explore more effective anti-ovarian cancer drugs, this study investigates the mechanism of three new anthraquinone compounds bearing different functional groups to camptothecin-resistance ovarian cell line A2780R2000. Cell viability was determined by MTT assay after treating A2780R2000 with the three new anthraquinone compounds. The results indicated that IC50 values are 33.44μM (Compound I), 25.77μM (Compound II) and 24.59μM (Compound III). Next, through cell cycle analysis, the results demonstrated that three new anthraquinone compounds not only induced A2780R2000 cell cycle arrest at early stage but also apoptosis at late stage. Besides, through apoptosis assay, the results indicated new anthraquinone compound induced apoptosis at late stage. Furthermore, the results of western blot show that the three new anthraquinone compounds lead to A2780R2000 apoptosis through intrinsic pathway. Theses results suggested that three new anthraquinone compounds may be potential new drugs for clinical cancer treatment in the future. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=anthraquinone" title="anthraquinone">anthraquinone</a>, <a href="https://publications.waset.org/abstracts/search?q=camptothecin" title=" camptothecin"> camptothecin</a>, <a href="https://publications.waset.org/abstracts/search?q=resistance" title=" resistance"> resistance</a>, <a href="https://publications.waset.org/abstracts/search?q=ovarian%20cancer" title=" ovarian cancer"> ovarian cancer</a> </p> <a href="https://publications.waset.org/abstracts/44883/effects-of-new-anthraquinone-derivatives-on-resistance-ovarian-cancer-cells-and-the-mechanism-investigation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/44883.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">403</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">304</span> Risk Factors and Biomarkers for the Recurrence of Ovarian Endometrioma: About the Immunoreactivity of Progesterone Receptor Isoform B and Nuclear Factor Kappa B.</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ae%20Ra%20Han">Ae Ra Han</a>, <a href="https://publications.waset.org/abstracts/search?q=Taek%20Hoo%20Lee"> Taek Hoo Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Sun%20Zoo%20Kim"> Sun Zoo Kim</a>, <a href="https://publications.waset.org/abstracts/search?q=Hwa%20Young%20%20Lee"> Hwa Young Lee</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Ovarian endometrioma is one of the important causes of poor ovarian reserve and up to half of them have recurred. However, the treatment for recurrence prevention has limited efficiency and repeated surgical management makes worsen the ovarian reserve. To find better management for recurrence prevention, we investigated risk factors and biomarkers for the recurrence of ovarian endometrioma. Methods: The medical records of women with the history of surgical dissection for ovarian endometrioma were collected. After exclusion of the cases with concurrent hysterectomy, been menopaused during follow-up, incomplete medical record, and loss of follow-up, a total of 134 women were enrolled. Immunohistochemical staining for progesterone receptor isoform B (PR-B) and nuclear factor kappa B (NFκB) was done with the fixed tissue blocks of their endometriomas which were collected at the time of surgery. Results: Severity of dysmenorrhea and co-existence of adenomyosis had significant correlation with recurrence of endometrioma. Increased PR-B (P = .041) and decreased NFκB (P = .036) immunoreactivity were found in recurrent group. Serum CA-125 level at the time of recurrence was higher than the highest level of CA-125 during follow-up in unrecurred group (55.6 vs. 21.3 U/mL, P = .014). Conclusion: We found that the severity of dysmenorrhea and coexistence of adenomyosis are risk factors for recurrence of ovarian endometrioma, and serial follow-up of CA-125 is effective to detect and prevent the recurrence. However, to determine the possibility of immunoreactivity of PR-B and NFκB as biomarkers for ovarian endometrioma, further studies of various races and large numbers with prospective design are needed. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=endometriosis" title="endometriosis">endometriosis</a>, <a href="https://publications.waset.org/abstracts/search?q=recurrence" title=" recurrence"> recurrence</a>, <a href="https://publications.waset.org/abstracts/search?q=biomarker" title=" biomarker"> biomarker</a>, <a href="https://publications.waset.org/abstracts/search?q=risk%20factor" title=" risk factor"> risk factor</a> </p> <a href="https://publications.waset.org/abstracts/50727/risk-factors-and-biomarkers-for-the-recurrence-of-ovarian-endometrioma-about-the-immunoreactivity-of-progesterone-receptor-isoform-b-and-nuclear-factor-kappa-b" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/50727.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">558</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">303</span> Ovarian Stimulation and Oocyte Cryopreservation for Fertility Preservation in Adolescent Females at the Royal Children’s Hospital: A Case Series</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kira%20Merigan">Kira Merigan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> BACKGROUND- Fertility preservation (FP) measures are increasingly recognised as an important consideration for children and adolescents planned to undergo potentially damaging gonadotoxic therapy. Worldwide, there are very few documented cases of FP in young females by way of ovarian stimulation and oocyte cryopreservation.AIM – To report a case series of mature oocyte cryopreservation in 5post-pubertal adolescents aged 14-17 years old, with varied medical conditions requiring gonadotoxic treatment. SETTING-These cases took place via a multidisciplinary team approach at The Royal Children’s Hospital, a large tertiary centre in Melbourne, Australia. INTERVENTION– Ovarian stimulation and oocyte collection was performed as detailed in each case. RESULTS –Across the 5 patients, 3-28 oocytes were retrieved. We report pre-treatment workup, complications, and delays to treatment. CONCLUSION- Oocyte cryopreservation may be a safe alternative to ovarian tissue cryopreservation (OTC) in the adolescent population <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=fertility%20preservation" title="fertility preservation">fertility preservation</a>, <a href="https://publications.waset.org/abstracts/search?q=adolescent" title=" adolescent"> adolescent</a>, <a href="https://publications.waset.org/abstracts/search?q=ovarian%20stimulation" title=" ovarian stimulation"> ovarian stimulation</a>, <a href="https://publications.waset.org/abstracts/search?q=oocyte%20cryopreservation" title=" oocyte cryopreservation"> oocyte cryopreservation</a> </p> <a href="https://publications.waset.org/abstracts/145436/ovarian-stimulation-and-oocyte-cryopreservation-for-fertility-preservation-in-adolescent-females-at-the-royal-childrens-hospital-a-case-series" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/145436.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">173</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">302</span> Body Dysmorphia in Adolescent's Fixation on Cosmetic Surgeries</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Noha%20El%20Toukhy">Noha El Toukhy</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The ‘beauty is good” stereotype suggests that people perceive attractive people as having several positive characteristics. Likewise, an “anomalous-is-bad” stereotype is hypothesized to facilitate biases against people with anomalous or less attractive faces. Researchers integrated both into a stereotype content model, which is one of the frameworks used in this study to assess how facial anomalies influence people’s social attitudes and, specifically, people’s ratings of warmth and competence. The mind perception theory, as well as the assessment of animalistic and mechanistic dehumanization against facially anomalous people, are two further frameworks that we are using in this study. This study will test the hypothesis that people have negative attitudes towards people with facial anomalies. We also hypothesize that people have negative biases toward faces with visible differences compared to faces without such differences regardless of the specific type of anomaly, as well as that individual differences in psychological dispositions bear on the expression of the anomalous-is-bad stereotype. Using highly controlled and some never-before-used face stimuli, this pre-registered study examines whether moral character influences perceptions of attractiveness, warmth, and competence for facial anomalies. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=adolescents" title="adolescents">adolescents</a>, <a href="https://publications.waset.org/abstracts/search?q=attractiveness" title=" attractiveness"> attractiveness</a>, <a href="https://publications.waset.org/abstracts/search?q=competence" title=" competence"> competence</a>, <a href="https://publications.waset.org/abstracts/search?q=social%20attitudes" title=" social attitudes"> social attitudes</a>, <a href="https://publications.waset.org/abstracts/search?q=warmth" title=" warmth"> warmth</a> </p> <a href="https://publications.waset.org/abstracts/154472/body-dysmorphia-in-adolescents-fixation-on-cosmetic-surgeries" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/154472.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">105</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">301</span> Comprehensive Multi-Omics Study Highlights Osteopontin/SPP1 in Ovarian Aging Control</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Chia-Jung%20Li">Chia-Jung Li</a>, <a href="https://publications.waset.org/abstracts/search?q=Li-Te%20Lin"> Li-Te Lin</a>, <a href="https://publications.waset.org/abstracts/search?q=Kuan-Hao%20Tsui"> Kuan-Hao Tsui</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The study identifies SPP1 as a potential gene associated with ovarian aging, revealing a significant decline in its expression in aged ovaries. SPP1, also known as osteopontin (OPN), is a multifunctional glycoprotein involved with regulatory proteins and pro-inflammatory immune chemokines. However, its genetic links to ovarian aging have not been extensively explored. Spatial transcriptomic analyses were conducted on ovaries from young and aged female mice, along with a sample from a 73-year-old individual. Additionally, single-cell RNA sequencing analysis was performed to identify associations between SPP1 and key genes. The study focused on crucial genes, including ITGAV, ITGB1, CD44, MMP3, and FN1, with a particular emphasis on the correlation between SPP1 and ITGB1. The findings indicate a significant decline in SPP1 expression in aged ovaries, which was consistent in the 73-year-old sample. Single-cell RNA sequencing unveiled associations between SPP1 and key genes, emphasizing a strong co-expression correlation between SPP1 and ITGB1. While the study provides valuable insights, further research is necessary to understand the broader implications and potential applications of SPP1 in ovarian aging. Translating these findings to clinical settings requires careful consideration. The identification of SPP1 as a gene implicated in ovarian aging opens new avenues for advancing precision medicine and refining treatment strategies for conditions related to ovarian aging. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=SPP1" title="SPP1">SPP1</a>, <a href="https://publications.waset.org/abstracts/search?q=ovarian%20aging" title=" ovarian aging"> ovarian aging</a>, <a href="https://publications.waset.org/abstracts/search?q=spatial%20transcriptomic" title=" spatial transcriptomic"> spatial transcriptomic</a>, <a href="https://publications.waset.org/abstracts/search?q=single-cell%20RNA%20sequencing" title=" single-cell RNA sequencing"> single-cell RNA sequencing</a> </p> <a href="https://publications.waset.org/abstracts/186479/comprehensive-multi-omics-study-highlights-osteopontinspp1-in-ovarian-aging-control" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/186479.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">50</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">300</span> Concentration Conditions of Industrially Valuable Accumulations of Gold Ore Mineralization of the Tulallar Ore-Bearing Structure</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Narmina%20Ismayilova">Narmina Ismayilova</a>, <a href="https://publications.waset.org/abstracts/search?q=Shamil%20Zabitov"> Shamil Zabitov</a>, <a href="https://publications.waset.org/abstracts/search?q=Fuad%20Askerzadeh"> Fuad Askerzadeh</a>, <a href="https://publications.waset.org/abstracts/search?q=Raqif%20Seyfullayev"> Raqif Seyfullayev</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Tulallar volcano-tectonic structure is located in the conjugation zone of the Gekgel horst-uplift, Dashkesan, and Agzhakend synclinorium. Regionally, these geological structures are an integral part of the Lok-Karabakh island arc system. Tulallar field is represented by three areas (Central, East, West). The area of the ore field is located within a partially eroded oblong volcano-tectonic depression. In the central part, the core is divided by the deep Tulallar-Chiragdara-Toganalinsky fault with arcuate fragments of the ring structure into three blocks -East, Central, and West, within which the same areas of the Tulallar field are located. In general, for the deposit, the position of both ore-bearing vein zones and ore-bearing blocks is controlled by fractures of two systems - sub-latitudinal and near-meridional orientations. Mineralization of gold-sulfide ores is confined to these zones of disturbances. The zones have a northwestern and northeastern (near-meridian) strike with a steep dip (70-85◦) to the southwest and southeast. The average thickness of the zones is 35 m; they are traced for 2.5 km along the strike and 500 m along with the dip. In general, for the indicated thickness, the zones contain an average of 1.56 ppm Au; however, areas enriched in noble metal are distinguished within them. The zones are complicated by postore fault tectonics. Gold mineralization is localized in the Kimmeridgian volcanics of andesi-basalt-porphyritic composition and their vitrolithoclastic, agglomerate tuffs, and tuff breccias. For the central part of the Tulallar ore field, a map of geochemical anomalies was built on the basis of analysis data carried out in an international laboratory. The total gold content ranges from 0.1-5 g/t, and in some places, even more than 5 g/t. The highest gold content is observed in the monoquartz facies among the secondary quartzites with quartz veins. The smallest amount of gold content appeared in the quartz-kaolin facies. And also, anomalous values of gold content are located in the upper part of the quartz vein. As a result, an en-echelon arrangement of anomalous values of gold along the strike and dip was revealed. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=geochemical%20anomaly" title="geochemical anomaly">geochemical anomaly</a>, <a href="https://publications.waset.org/abstracts/search?q=gold%20deposit" title=" gold deposit"> gold deposit</a>, <a href="https://publications.waset.org/abstracts/search?q=mineralization" title=" mineralization"> mineralization</a>, <a href="https://publications.waset.org/abstracts/search?q=Tulallar" title=" Tulallar"> Tulallar</a> </p> <a href="https://publications.waset.org/abstracts/135010/concentration-conditions-of-industrially-valuable-accumulations-of-gold-ore-mineralization-of-the-tulallar-ore-bearing-structure" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/135010.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">198</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">299</span> Genetic Determinants of Ovarian Response to Gonadotropin Stimulation in Women Undergoing Assisted Reproductive Treatment</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=D.%20Tohlob">D. Tohlob</a>, <a href="https://publications.waset.org/abstracts/search?q=E.%20Abo%20Hashem"> E. Abo Hashem</a>, <a href="https://publications.waset.org/abstracts/search?q=N.%20Ghareeb"> N. Ghareeb</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Ghanem"> M. Ghanem</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20Elfarahaty"> R. Elfarahaty</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20A.%20Roberts"> S. A. Roberts</a>, <a href="https://publications.waset.org/abstracts/search?q=P.%20Pemberton"> P. Pemberton</a>, <a href="https://publications.waset.org/abstracts/search?q=L.%20Mohiyiddeen"> L. Mohiyiddeen</a>, <a href="https://publications.waset.org/abstracts/search?q=W.%20G.%20Newman"> W. G. Newman </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Gonadotropin stimulation is used in females undergoing assisted reproductive treatment for ovulation induction, but ovarian response is variable and unpredictable in these women. More effective protocols and individualization of treatment are needed to increase the success rate of IVF/ICSI cycles. We genotyped seven variants reported in previous studies to be associated with ovarian response (number of ova retrieved and total gonadotropin dose) in women undergoing IVF treatment including FSHR variants Asn 680 Ser (c.2039 A > G), Thr 307 Ala (c. 919 > A), -29 G > A, HRG c.610 C > T gene, BMP15 -9 C > G, AMH Ile 49 Ser (c.146 G > T), and AMHR -489A˃G in 118 Egyptian females attending Mansoura Integrated Fertility Center in Egypt, these females were undergoing their first cycle of controlled ovarian hyper stimulation for IVF/ICSI treatment. They were analyzed by TaqMan allelic discrimination assay in Manchester Center of Genomic Medicine. We found no evidence of any significant difference (p value < 0.05) in the number of eggs retrieved or the gonadotropin dose used between individuals in all genotypes except for HRG c.610 C > T gene polymorphism where regression analysis gives a p value of 0.04 with a fewer eggs number in TT genotyped females. These results indicate that these variants do not provide sufficient clinically relevant data to individualize the treatment protocols. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=controlled%20ovarian%20hyperstimulation" title="controlled ovarian hyperstimulation">controlled ovarian hyperstimulation</a>, <a href="https://publications.waset.org/abstracts/search?q=gene%20variants" title=" gene variants"> gene variants</a>, <a href="https://publications.waset.org/abstracts/search?q=ovarian%20response" title=" ovarian response"> ovarian response</a>, <a href="https://publications.waset.org/abstracts/search?q=assisted%20reproduction" title=" assisted reproduction"> assisted reproduction</a> </p> <a href="https://publications.waset.org/abstracts/37258/genetic-determinants-of-ovarian-response-to-gonadotropin-stimulation-in-women-undergoing-assisted-reproductive-treatment" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/37258.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">323</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">298</span> Gross Anatomical Study on the Tributaries of the Hepatic Portal Vein in Cattle Egret (Bubulcus Ibis)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Elsayed%20Fath%20Khalifa">Elsayed Fath Khalifa</a>, <a href="https://publications.waset.org/abstracts/search?q=Samer%20Mohamed%20Daghash"> Samer Mohamed Daghash</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The aim of the current work study to increase the anatomical knowledge about the cattle egret which considered economically important for farmers. The study was carried out on ten adult, apparently healthy cattle egrets of both sexes. Each bird was exsanguinated; the caudal vena cava was cannulated and flushed with warm normal saline solution (0.9%) then injected with blue colored neoprine (60%) latex in order to study the tributaries of the hepatic portal vein. The origin, course and tributaries of the right and left hepatic portal veins were studied. The hepatic portal venous system collected venous blood from the abdominal viscera including; glandular and muscular stomachs, liver, pancreas, spleen, small intestine and large intestine. The hepatic portal vein was formed by the left and the right hepatic portal veins. The smaller left one drained blood from the glandular and muscular stomachs through the ventral and the left proventriculus as well as the left gastric veins. The most tributaries of the right hepatic portal vein drained blood from the rest of the gastrointestinal tract and the spleen by the proventriculosplenic, the gastropancreaticoduodenal and the common mesenteric veins. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cattle%20egret" title="cattle egret">cattle egret</a>, <a href="https://publications.waset.org/abstracts/search?q=common%20mesenteric%20vein" title=" common mesenteric vein"> common mesenteric vein</a>, <a href="https://publications.waset.org/abstracts/search?q=hepatic%20portal%20vein" title=" hepatic portal vein"> hepatic portal vein</a>, <a href="https://publications.waset.org/abstracts/search?q=anatomy" title=" anatomy"> anatomy</a> </p> <a href="https://publications.waset.org/abstracts/24742/gross-anatomical-study-on-the-tributaries-of-the-hepatic-portal-vein-in-cattle-egret-bubulcus-ibis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/24742.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">416</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">297</span> Optimal Feature Extraction Dimension in Finger Vein Recognition Using Kernel Principal Component Analysis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Amir%20Hajian">Amir Hajian</a>, <a href="https://publications.waset.org/abstracts/search?q=Sepehr%20Damavandinejadmonfared"> Sepehr Damavandinejadmonfared</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this paper the issue of dimensionality reduction is investigated in finger vein recognition systems using kernel Principal Component Analysis (KPCA). One aspect of KPCA is to find the most appropriate kernel function on finger vein recognition as there are several kernel functions which can be used within PCA-based algorithms. In this paper, however, another side of PCA-based algorithms -particularly KPCA- is investigated. The aspect of dimension of feature vector in PCA-based algorithms is of importance especially when it comes to the real-world applications and usage of such algorithms. It means that a fixed dimension of feature vector has to be set to reduce the dimension of the input and output data and extract the features from them. Then a classifier is performed to classify the data and make the final decision. We analyze KPCA (Polynomial, Gaussian, and Laplacian) in details in this paper and investigate the optimal feature extraction dimension in finger vein recognition using KPCA. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=biometrics" title="biometrics">biometrics</a>, <a href="https://publications.waset.org/abstracts/search?q=finger%20vein%20recognition" title=" finger vein recognition"> finger vein recognition</a>, <a href="https://publications.waset.org/abstracts/search?q=principal%20component%20analysis%20%28PCA%29" title=" principal component analysis (PCA)"> principal component analysis (PCA)</a>, <a href="https://publications.waset.org/abstracts/search?q=kernel%20principal%20component%20analysis%20%28KPCA%29" title=" kernel principal component analysis (KPCA)"> kernel principal component analysis (KPCA)</a> </p> <a href="https://publications.waset.org/abstracts/14476/optimal-feature-extraction-dimension-in-finger-vein-recognition-using-kernel-principal-component-analysis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/14476.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">369</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">296</span> Borderline Ovarian Tumor: Management of Recurrence After Conservative Surgical Treatment</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ghorbeli%20Eya">Ghorbeli Eya</a>, <a href="https://publications.waset.org/abstracts/search?q=Naija%20Lamia"> Naija Lamia</a>, <a href="https://publications.waset.org/abstracts/search?q=Khessairi%20Nayssem"> Khessairi Nayssem</a>, <a href="https://publications.waset.org/abstracts/search?q=Saadallah%20Fatma"> Saadallah Fatma</a>, <a href="https://publications.waset.org/abstracts/search?q=Slimane%20Maher"> Slimane Maher</a>, <a href="https://publications.waset.org/abstracts/search?q=Tarek%20Ben%20Dhiab"> Tarek Ben Dhiab</a> </p> <p class="card-text"><strong>Abstract:</strong></p> INTRODUCTION: Borderline ovarian tumors account for 15 to 20% of ovarian tumors. Prognostic factors of recurrence include the stage of the disease, presence of peritoneal implants, micropapillary pattern, microinvasion and intra-epithelial carcinoma. Fertility sparing constitutes a major therapeutic issue in young patients that leads to conservative surgical treatment in specific cases. METHODS: We conducted a retrospective descriptive study including patients treated at the Salah Azaiez Institute for Borderline Ovarian Tumor who underwent conservative surgical treatment from 2003 to 2018. RESULTS: Nine patients were included in our study. The median age was 33 years. Three patients were nulliparous. Given the age, conservative treatment was indicated in all these patients. Cystectomy without ovariectomy was indicated in 5 of the 9 women, which was within the margin of tumor resection on definitive anatomopathic examination in 3 of the 5 women. In contrast, given the impossibility of ovarian conservation, total annexectomy was carried out in 4 of all these women. All of the patients were followed regularly postoperatively; three had a carcinomatous transformation as an ovarian adenocarcinoma at an average interval of 18 months. Among these three patients, a single one presented intra-peritoneal metastases, requiring radical surgical treatment and adjuvant chemotherapy with 6 cures of Carbo-Taxol, with a good tolerance and a complete response. Moreover, one patient had a recurrence on the contralateral ovary as a Borderline mucinous ovarian tumor. For the remaining four women, after a median follow-up of 35 months, one patient fell spontaneously pregnant during follow-up, and three patients were in complete remission at 16 months. CONCLUSION: Borderline tumors of the ovary usually occur in young patients, which makes conservative treatment advisable if possible, but this always comes with a risk of recurrence and/or carcinomatous transformation, especially if the conservative surgical procedure was a cystectomy instead of a total annexectomy, and even more so if the resection margins were tumoral. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ovarian%20tumor" title="ovarian tumor">ovarian tumor</a>, <a href="https://publications.waset.org/abstracts/search?q=conservative%20treatment" title=" conservative treatment"> conservative treatment</a>, <a href="https://publications.waset.org/abstracts/search?q=surgical%20management" title=" surgical management"> surgical management</a>, <a href="https://publications.waset.org/abstracts/search?q=borderline%20ovarian%20tumor" title=" borderline ovarian tumor"> borderline ovarian tumor</a>, <a href="https://publications.waset.org/abstracts/search?q=recurrence%20management" title=" recurrence management"> recurrence management</a> </p> <a href="https://publications.waset.org/abstracts/190122/borderline-ovarian-tumor-management-of-recurrence-after-conservative-surgical-treatment" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/190122.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">35</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">295</span> Sexual Satifaction in Women with Polycystic Ovarian Syndrome</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nashi%20Khan">Nashi Khan</a>, <a href="https://publications.waset.org/abstracts/search?q=Amina%20Khalid"> Amina Khalid</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Aim: The purpose of this research was to find the psychiatric morbidity and level of sexual satisfaction among women with polycystic ovarian syndrome and their comparison with women with general medical conditions and to examine the correlation between psychiatric morbidity and sexual satisfaction among these women. Design: Cross sectional research design was used. Method: A total of 176 (M age = 30, SD = 5.83) women were recruited from both private and public sector hospitals in Pakistan. About 88 (50%) of the participants were diagnosed with polycystic ovarian syndrome (cases), whereas other 50% belonged to control group. Data were collected using semi structured interview. Sexual satisfaction scale for women (SSS-W) was administered to measure sexual satisfaction level and psychiatric morbidity was assessed by Symptom Checklist-Revised. Results: Results showed that participant’s depression and anxiety level had significant negative correlation with their sexual satisfaction level, whereas, anxiety and depression shared a significant positive correlation. There was a significant difference in the scores for sexual satisfaction, depression and anxiety for both cases and controls. These results suggested that women suffering from polycystic ovarian syndrome tend to be less sexually satisfied and experienced relatively more symptoms of depression and anxiety as compared to controls. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=level%20of%20sexual%20satisfaction" title="level of sexual satisfaction">level of sexual satisfaction</a>, <a href="https://publications.waset.org/abstracts/search?q=psychiatric%20morbidity" title=" psychiatric morbidity"> psychiatric morbidity</a>, <a href="https://publications.waset.org/abstracts/search?q=polycystic%20ovarian%20syndrome" title=" polycystic ovarian syndrome"> polycystic ovarian syndrome</a> </p> <a href="https://publications.waset.org/abstracts/36350/sexual-satifaction-in-women-with-polycystic-ovarian-syndrome" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/36350.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">467</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">294</span> A Prenylflavanoid, HME5 with Antiproliferative Activity in Human Ovarian Cancer Cells</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mashitoh%20Abd%20Rahman">Mashitoh Abd Rahman</a>, <a href="https://publications.waset.org/abstracts/search?q=Najihah%20Mohd%20Hashim"> Najihah Mohd Hashim</a>, <a href="https://publications.waset.org/abstracts/search?q=Faiqah%20Ramli"> Faiqah Ramli</a>, <a href="https://publications.waset.org/abstracts/search?q=Syam%20Mohan"> Syam Mohan</a>, <a href="https://publications.waset.org/abstracts/search?q=Noraziah%20Nordin"> Noraziah Nordin</a>, <a href="https://publications.waset.org/abstracts/search?q=Hamed%20Karimian"> Hamed Karimian</a>, <a href="https://publications.waset.org/abstracts/search?q=Hapipah%20Mohd%20Ali"> Hapipah Mohd Ali</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Ovarian cancer is the most lethal gynecological malignancies. HME5, a prenylflavanoid has been isolated from local medicinal plant. This compound has been reported to possess a broad spectrum of biological activities including anticancer property. However, the potential of HME5 as an antiproliferative and cytotoxic agent on an ovarian cancer cells has not yet been investigated. In this present study, we examined the antiproliferative and cytotoxic effect of HME5 on Caov-3 (Human Ovarian Adenocarcinoma) cell line by using 3-[4,5-dimethylthizol-2-y]-2,5-diphenyltetrazolium bromide (MTT) assay, Acridine orange and propidium Iodide (AOPi) and cell cycle analysis study. HME5 has shown to inhibit Caov-3 in a time-dependent manner with the IC50 values of 5µg/ml, 2µg/ml and 1µg/ml after 24h, 48h and 72h treatment, respectively. Morphological study from AOPi analysis showed that HME5 induced apoptosis after 24 and 48h post-treatment. Nevertheless, HME5 exhibited cell cycle arrest at G1 phase as indicated in flow cytometry cell cycle profiling. In conclusion, HME5 inhibited proliferation of Caov-3 through induction of apoptosis and cell cycle arrest at G1 phase. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=apoptosis" title="apoptosis">apoptosis</a>, <a href="https://publications.waset.org/abstracts/search?q=prenylflavanoid" title=" prenylflavanoid"> prenylflavanoid</a>, <a href="https://publications.waset.org/abstracts/search?q=ovarian%20cancer" title=" ovarian cancer"> ovarian cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=HME5" title=" HME5 "> HME5 </a> </p> <a href="https://publications.waset.org/abstracts/13503/a-prenylflavanoid-hme5-with-antiproliferative-activity-in-human-ovarian-cancer-cells" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/13503.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">467</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">293</span> Ectopic Pregnancy: A Case of Consecutive Occurrences of Different Types</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Wania%20Mohammad%20Akram">Wania Mohammad Akram</a>, <a href="https://publications.waset.org/abstracts/search?q=Swetha%20Kannan"> Swetha Kannan</a>, <a href="https://publications.waset.org/abstracts/search?q=Urooj%20Shahid"> Urooj Shahid</a>, <a href="https://publications.waset.org/abstracts/search?q=Aisha%20Sajjad"> Aisha Sajjad</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Ovarian ectopic pregnancy, a rare manifestation of ectopic gestation, involves the implantation of a fertilized egg on the ovarian surface. This condition poses diagnostic challenges and is associated with significant maternal morbidity if not promptly managed. This report presents the case of a 33-year-old nulliparous woman with a history of polycystic ovary syndrome (PCOS) undergoing ovulation induction therapy. Following her first conception in October 2021, she presented with symptoms of per vaginal spotting and low back pain, prompting a diagnosis of left adnexal ectopic pregnancy confirmed by transvaginal ultrasound and serum beta-human chorionic gonadotropin (B-HCG) levels. Medical management with methotrexate was initiated successfully. In August 2022, the patient conceived again, with subsequent ultrasound revealing a large pelvic collection suggestive of a complex ectopic pregnancy involving both ovaries. Despite initial stability, she developed abdominal pain necessitating emergency laparoscopy, which revealed an ovarian ectopic pregnancy with hemoperitoneum. Laparotomy was performed due to the complexity of the presentation, and histopathology confirmed viable chorionic villi within ovarian tissue. This case underscores the clinical management challenges posed by ovarian ectopic pregnancies, particularly in patients with previous ectopic pregnancies. The discussion reviews current literature on diagnostic modalities, treatment strategies, and outcomes associated with ovarian ectopic pregnancies, emphasizing the role of surgical intervention in cases refractory to conservative management. Tailored approaches considering individual patient factors are crucial to optimize outcomes and preserve fertility in such complex scenarios. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=obgyn" title="obgyn">obgyn</a>, <a href="https://publications.waset.org/abstracts/search?q=ovarian%20ectopic%20pregnancy" title=" ovarian ectopic pregnancy"> ovarian ectopic pregnancy</a>, <a href="https://publications.waset.org/abstracts/search?q=laproscopy" title=" laproscopy"> laproscopy</a>, <a href="https://publications.waset.org/abstracts/search?q=pcos" title=" pcos"> pcos</a> </p> <a href="https://publications.waset.org/abstracts/188354/ectopic-pregnancy-a-case-of-consecutive-occurrences-of-different-types" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/188354.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">43</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">292</span> WT1 Exprassion in Malignant Surface Epithelial Ovarian Tumors</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mahmoodreza%20Tahamtan">Mahmoodreza Tahamtan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Malignant surface epithelial ovarian tumors (SEOT) account for approximately 90% of primary ovarian cancer. Wilms tumor gene (WT1) product was defined as a tumor suppressor gene, but today it is considered capable of performing oncogenic functions. There seems to be differences in WT1 expression patterns among SEOT subtypes. We evaluate the immunohistochemical expression of WT1 protein among different histologic subtypes of SEOT. Materials and Methods: Immunohistochemistry for WT1 was done on 35 serous cystadenocarcinomas, 9 borderline serous tumors, 3 mucinous cystadenocarcinomas, 10 borderline mucinous tumors, 7 endometrioid ovarian carcinomas, 3 clear cell carcinomas, 1 malignant Brenner tumor, 2 metastatic adenocarcinomas, and 6 endometrial adenocarcinomas. A tumor was considered negative if < 1% of tumor cells were stained.Positive reactions were graded as follows:1+,1%-24%; 2+,25%-49%; 3+,50%-74%; 4+,75%-100%. Results: Of the 35 cases of ovarian serous cystadenocarcinoma, 30(85.7%) were diffusely positive (3+,4+),4 showed reactivity of < 50% of the tumor cells (1+,2+), and one were negative. All 9 borderline serous tumors showed immunoreactivity with WT1. All the mucinous tumors(n:13), endometrioid carcinomas (n: 7), clear cell carcinomas (n: 3), metastatic adenocarcinomas (n: 2) and primary endometrial carcinomas (n:6) were negative. The single malignant Brenner tumor showed a positive reaction for WT1(4+) Conclusion: WT1 is a good marker to distinguish primary ovarian serous carcinomas from other surface epithelial tumors (especially endometrioid subtype) and metastatic carcinomas (especially endometrial serous carcinoma), other than malignant mesothelioma. We cannot rely to the degree of expression inorder to separate high grade borderline serous tumors from low grade ones. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=WT1" title="WT1">WT1</a>, <a href="https://publications.waset.org/abstracts/search?q=ovary" title=" ovary"> ovary</a>, <a href="https://publications.waset.org/abstracts/search?q=epithelial%20tumors" title=" epithelial tumors"> epithelial tumors</a>, <a href="https://publications.waset.org/abstracts/search?q=malignant" title=" malignant"> malignant</a> </p> <a href="https://publications.waset.org/abstracts/159905/wt1-exprassion-in-malignant-surface-epithelial-ovarian-tumors" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/159905.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">112</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">291</span> Exercise Intervention for Women After Treatment for Ovarian Cancer: Realist Evaluation of a Co-Designed Implementation Process</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Deirdre%20Mc%20Grath">Deirdre Mc Grath</a>, <a href="https://publications.waset.org/abstracts/search?q=Joanne%20Reid"> Joanne Reid</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Ovarian cancer is the leading cause of mortality among gynaecologic cancers in developed countries and the seventh most common cancer worldwide, with nearly 240,000 women diagnosed each year. Although it is recognized engaging in exercise results in positive health care outcomes, women with ovarian cancer are reluctant to participate. No evidence currently exists focusing on how to successfully implement an exercise intervention program for patients with ovarian cancer, using a realist approach. There is a requirement for the implementation of exercise programmes within the oncology health care setting as engagement in such interventions has positive health care outcomes for women with ovarian cancer both during and following treatment. Aim: To co-design the implementation of an exercise intervention for women following treatment for ovarian cancer. Methods: This study is a realist evaluation using quantitative and qualitative methods of data collection and analysis. Realist evaluation is well-established within the health and social care setting and has, in relation to this study, enabled a flexible approach to investigate how to optimise implementation of an exercise intervention for this patient population. This single centre study incorporates three stages in order to identify the underlying contexts and mechanisms which lead to the successful implementation of an exercise intervention for women who have had treatment for ovarian cancer. Stage 1 - A realist literature review. Stage 2 -Co-design of the implementation of an exercise intervention with women following treatment for ovarian cancer, their carer’s, and health care professionals. Stage 3 –Implementation of an exercise intervention with women following treatment for ovarian cancer. Evaluation of the implementation of the intervention from the perspectives of the women who participated in the intervention, their informal carers, and health care professionals. The underlying programme theory initially conceptualised before and during the realist review was developed further during the co-design stage. The evolving programme theory in relation to how to successfully implement an exercise for these women is currently been refined and tested during the final stage of this realist evaluation which is the implementation and evaluation stage. Results: This realist evaluation highlights key issues in relation to the implementation of an exercise intervention within this patient population. The underlying contexts and mechanisms which influence recruitment, adherence, and retention rates of participants are identified. Conclusions: This study will inform future research on the implementation of exercise interventions for this patient population. It is anticipated that this intervention will be implemented into practice as part of standard care for this group of patients. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=exercise" title="exercise">exercise</a>, <a href="https://publications.waset.org/abstracts/search?q=ovarian%20cancer" title=" ovarian cancer"> ovarian cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=co-design" title=" co-design"> co-design</a>, <a href="https://publications.waset.org/abstracts/search?q=implementation" title=" implementation"> implementation</a> </p> <a href="https://publications.waset.org/abstracts/143594/exercise-intervention-for-women-after-treatment-for-ovarian-cancer-realist-evaluation-of-a-co-designed-implementation-process" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/143594.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">125</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">290</span> Targeting Mre11 Nuclease Overcomes Platinum Resistance and Induces Synthetic Lethality in Platinum Sensitive XRCC1 Deficient Epithelial Ovarian Cancers</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Adel%20Alblihy">Adel Alblihy</a>, <a href="https://publications.waset.org/abstracts/search?q=Reem%20Ali"> Reem Ali</a>, <a href="https://publications.waset.org/abstracts/search?q=Mashael%20Algethami"> Mashael Algethami</a>, <a href="https://publications.waset.org/abstracts/search?q=Ahmed%20Shoqafi"> Ahmed Shoqafi</a>, <a href="https://publications.waset.org/abstracts/search?q=Michael%20S.%20Toss"> Michael S. Toss</a>, <a href="https://publications.waset.org/abstracts/search?q=Juliette%20Brownlie"> Juliette Brownlie</a>, <a href="https://publications.waset.org/abstracts/search?q=Natalie%20J.%20Tatum"> Natalie J. Tatum</a>, <a href="https://publications.waset.org/abstracts/search?q=Ian%20Hickson"> Ian Hickson</a>, <a href="https://publications.waset.org/abstracts/search?q=Paloma%20Ordonez%20Moran"> Paloma Ordonez Moran</a>, <a href="https://publications.waset.org/abstracts/search?q=Anna%20Grabowska"> Anna Grabowska</a>, <a href="https://publications.waset.org/abstracts/search?q=Jennie%20N.%20Jeyapalan"> Jennie N. Jeyapalan</a>, <a href="https://publications.waset.org/abstracts/search?q=Nigel%20P.%20Mongan"> Nigel P. Mongan</a>, <a href="https://publications.waset.org/abstracts/search?q=Emad%20A.%20Rakha"> Emad A. Rakha</a>, <a href="https://publications.waset.org/abstracts/search?q=Srinivasan%20Madhusudan"> Srinivasan Madhusudan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Platinum resistance is a clinical challenge in ovarian cancer. Platinating agents induce DNA damage which activate Mre11 nuclease directed DNA damage signalling and response (DDR). Upregulation of DDR may promote chemotherapy resistance. Here we have comprehensively evaluated Mre11 in epithelial ovarian cancers. In clinical cohort that received platinum- based chemotherapy (n=331), Mre11 protein overexpression was associated with aggressive phenotype and poor progression free survival (PFS) (p=0.002). In the ovarian cancer genome atlas (TCGA) cohort (n=498), Mre11 gene amplification was observed in a subset of serous tumours (5%) which correlated highly with Mre11 mRNA levels (p<0.0001). Altered Mre11 levels was linked with genome wide alterations that can influence platinum sensitivity. At the transcriptomic level (n=1259), Mre11 overexpression was associated with poor PFS (p=0.003). ROC analysis showed an area under the curve (AUC) of 0.642 for response to platinum-based chemotherapy. Pre-clinically, Mre11 depletion by gene knock down or blockade by small molecule inhibitor (Mirin) reversed platinum resistance in ovarian cancer cells and in 3D spheroid models. Importantly, Mre11 inhibition was synthetically lethal in platinum sensitive XRCC1 deficient ovarian cancer cells and 3D-spheroids. Selective cytotoxicity was associated with DNA double strand break (DSB) accumulation, S-phase cell cycle arrest and increased apoptosis. We conclude that pharmaceutical development of Mre11 inhibitors is a viable clinical strategy for platinum sensitization and synthetic lethality in ovarian cancer. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=MRE11%3B%20XRCC1" title="MRE11; XRCC1">MRE11; XRCC1</a>, <a href="https://publications.waset.org/abstracts/search?q=ovarian%20cancer" title=" ovarian cancer"> ovarian cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=platinum%20sensitization" title=" platinum sensitization"> platinum sensitization</a>, <a href="https://publications.waset.org/abstracts/search?q=synthetic%20lethality" title=" synthetic lethality"> synthetic lethality</a> </p> <a href="https://publications.waset.org/abstracts/151440/targeting-mre11-nuclease-overcomes-platinum-resistance-and-induces-synthetic-lethality-in-platinum-sensitive-xrcc1-deficient-epithelial-ovarian-cancers" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/151440.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">135</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">289</span> Multi-Omics Investigation of Ferroptosis-Related Gene Expression in Ovarian Aging and the Impact of Nutritional Intervention</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Chia-Jung%20Li">Chia-Jung Li</a>, <a href="https://publications.waset.org/abstracts/search?q=Kuan-Hao%20Tsui"> Kuan-Hao Tsui</a> </p> <p class="card-text"><strong>Abstract:</strong></p> As women age, the quality of their oocytes deteriorates irreversibly, leading to reduced fertility. To better understand the role of Ferroptosis-related genes in ovarian aging, we employed a multi-omics analysis approach, including spatial transcriptomics, single-cell RNA sequencing, human ovarian pathology, and clinical biopsies. Our study identified excess lipid peroxide accumulation in aging germ cells, metal ion accumulation via oxidative reduction, and the interaction between ferroptosis and cellular energy metabolism. We used multi-histological prediction of ferroptosis key genes to evaluate 75 patients with ovarian aging insufficiency and then analyzed changes in hub genes after supplementing with DHEA, Ubiquinol CoQ10, and Cleo-20 T3 for two months. Our results demonstrated a significant increase in TFRC, GPX4, NCOA4, and SLC3A2, which were consistent with our multi-component prediction. We theorized that these supplements increase the mitochondrial tricarboxylic acid cycle (TCA) or electron transport chain (ETC), thereby increasing antioxidant enzyme GPX4 levels and reducing lipid peroxide accumulation and ferroptosis. Overall, our findings suggest that supplementation intervention significantly improves IVF outcomes in senescent cells by enhancing metal ion and energy metabolism and enhancing oocyte quality in aging women. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=multi-omics" title="multi-omics">multi-omics</a>, <a href="https://publications.waset.org/abstracts/search?q=nutrients" title=" nutrients"> nutrients</a>, <a href="https://publications.waset.org/abstracts/search?q=ferroptosis" title=" ferroptosis"> ferroptosis</a>, <a href="https://publications.waset.org/abstracts/search?q=ovarian%20aging" title=" ovarian aging"> ovarian aging</a> </p> <a href="https://publications.waset.org/abstracts/167764/multi-omics-investigation-of-ferroptosis-related-gene-expression-in-ovarian-aging-and-the-impact-of-nutritional-intervention" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/167764.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">109</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">288</span> Human Coronary Sinus Venous System as a Target for Clinical Procedures</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Wies%C5%82awa%20Klimek-Piotrowska">Wiesława Klimek-Piotrowska</a>, <a href="https://publications.waset.org/abstracts/search?q=Mateusz%20K.%20Ho%C5%82da"> Mateusz K. Hołda</a>, <a href="https://publications.waset.org/abstracts/search?q=Mateusz%20Koziej"> Mateusz Koziej</a>, <a href="https://publications.waset.org/abstracts/search?q=Katarzyna%20Pi%C4%85tek">Katarzyna Piątek</a>, <a href="https://publications.waset.org/abstracts/search?q=Jakub%20Ho%C5%82da"> Jakub Hołda </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: The coronary sinus venous system (CSVS), which has always been overshadowed by the coronary arterial tree, has recently begun to attract more attention. Since it is a target for clinicians the knowledge of its anatomy is essential. Cardiac resynchronization therapy, catheter ablation of cardiac arrhythmias, defibrillation, perfusion therapy, mitral valve annuloplasty, targeted drug delivery, and retrograde cardioplegia administration are commonly used therapeutic methods involving the CSVS. The great variability in the course of coronary veins and tributaries makes the diagnostic and therapeutic processes difficult. Our aim was to investigate detailed anatomy of most common clinically used CSVS`s structures: the coronary sinus with its ostium, great cardiac vein, posterior vein of the left ventricle, middle cardiac vein and oblique vein of the left atrium. Methodology: This is a prospective study of 70 randomly selected autopsied hearts dissected from adult humans (Caucasian) aged 50.1±17.6 years old (24.3% females) with BMI=27.6±6.7 kg/m2. The morphology of the CSVS was assessed as well as its precise measurements were performed. Results: The coronary sinus (CS) with its ostium was present in all hearts. The mean CS ostium diameter was 9.9±2.5mm. Considered ostium was covered by its valve in 87.1% with mean valve height amounted 5.1±3.1mm. The mean percentage coverage of the CS ostium by the valve was 56%. The Vieussens valve was present in 71.4% and was unicuspid in 70%, bicuspid in 26% and tricuspid in 4% of hearts. The great cardiac vein was present in all cases. The oblique vein of the left atrium was observed in 84.3% of hearts with mean length amounted 20.2±9.3mm and mean ostium diameter 1.4±0.9mm. The average length of the CS (from the CS ostium to the Vieussens valve) was 31.1±9.5mm or (from the CS ostium to the ostium of the oblique vein of the left atrium) 28.9±10.1mm and both were correlated with the heart weight (r=0.47; p=0.00 and r=0.38; p=0.006 respectively). In 90.5% the ostium of the oblique vein of the left atrium was located proximally to the Vieussens valve, in remaining cases was distally. The middle cardiac vein was present in all hearts and its valve was noticed in more than half of all the cases (52.9%). The posterior vein of the left ventricle was observed in 91.4% of cases. Conclusions: The CSVS is vastly variable and none of basic hearts parameters is a good predictor of its morphology. The Vieussens valve could be a significant obstacle during CS cannulation. Caution should be exercised in this area to avoid coronary sinus perforation. Because of the higher incidence of the presence of the oblique vein of the left atrium than the Vieussens valve, the vein orifice is more useful in determining the CS length. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cardiac%20resynchronization%20therapy" title="cardiac resynchronization therapy">cardiac resynchronization therapy</a>, <a href="https://publications.waset.org/abstracts/search?q=coronary%20sinus" title=" coronary sinus"> coronary sinus</a>, <a href="https://publications.waset.org/abstracts/search?q=Thebesian%20valve" title=" Thebesian valve"> Thebesian valve</a>, <a href="https://publications.waset.org/abstracts/search?q=Vieussens%20valve" title=" Vieussens valve "> Vieussens valve </a> </p> <a href="https://publications.waset.org/abstracts/27594/human-coronary-sinus-venous-system-as-a-target-for-clinical-procedures" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/27594.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">308</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=anomalous%20course%20of%20ovarian%20vein&page=2">2</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=anomalous%20course%20of%20ovarian%20vein&page=3">3</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=anomalous%20course%20of%20ovarian%20vein&page=4">4</a></li> <li class="page-item"><a class="page-link" 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