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<div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Chemical compound</div> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox" style="border-spacing:2px;"><caption class="infobox-title"><span title="International nonproprietary name (INN): Valopicitabine">Valopicitabine</span></caption><tbody><tr><td colspan="2" class="infobox-image notheme" style="background-color: #f8f9fa;"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:Valopicitabine_structure.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/96/Valopicitabine_structure.png/220px-Valopicitabine_structure.png" decoding="async" width="220" height="148" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/96/Valopicitabine_structure.png/330px-Valopicitabine_structure.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/96/Valopicitabine_structure.png/440px-Valopicitabine_structure.png 2x" data-file-width="1187" data-file-height="799" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Clinical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Anatomical_Therapeutic_Chemical_Classification_System" title="Anatomical Therapeutic Chemical Classification System">ATC code</a></th><td class="infobox-data"><style data-mw-deduplicate="TemplateStyles:r1126788409">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style><div class="plainlist"><ul><li>None</li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Legal status</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">Legal status</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"> <ul><li><small><abbr class="country-name" title="United States">US</abbr>:</small> Investigational drug</li></ul></div> </td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Identifiers</th></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/IUPAC_nomenclature_of_chemistry" title="IUPAC nomenclature of chemistry">IUPAC name</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all; text-align:left; padding-left:1.5em; text-indent:-1.5em;"><li style="line-height: inherit; margin: 0"><div style="font-size: 97%;">[(2<i>R</i>,3<i>R</i>,4<i>R</i>,5<i>R</i>)-5-(4-amino-2-oxopyrimidin-1-yl)-4-hydroxy-2-(hydroxymethyl)-4-methyloxolan-3-yl] (2<i>S</i>)-2-amino-3-methylbutanoate</div></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CAS_Registry_Number" title="CAS Registry Number">CAS Number</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="commonchemistry.cas.org"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=640281-90-9">640281-90-9</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/PubChem#CID" title="PubChem">PubChem</a> <span style="font-weight:normal"><abbr title="Compound ID">CID</abbr></span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="pubchem.ncbi.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/6918726">6918726</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/DrugBank" title="DrugBank">DrugBank</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.drugbank.ca"><a rel="nofollow" class="external text" href="https://www.drugbank.ca/drugs/DB13920">DB13920</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChemSpider" title="ChemSpider">ChemSpider</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.chemspider.com"><a rel="nofollow" class="external text" href="https://www.chemspider.com/Chemical-Structure.5293918.html">5293918</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Unique_Ingredient_Identifier" title="Unique Ingredient Identifier">UNII</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="precision.fda.gov"><a rel="nofollow" class="external text" href="https://precision.fda.gov/uniisearch/srs/unii/I2T0B5G94M">I2T0B5G94M</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/KEGG" title="KEGG">KEGG</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.kegg.jp"><a rel="nofollow" class="external text" href="https://www.kegg.jp/entry/D09028">D09028</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChEMBL" title="ChEMBL">ChEMBL</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chembl/explore/compound/ChEMBL1743757">ChEMBL1743757</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CompTox_Chemicals_Dashboard" title="CompTox Chemicals Dashboard">CompTox Dashboard</a> <span style="font-weight:normal">(<abbr title="U.S. Environmental Protection Agency">EPA</abbr>)</span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="comptox.epa.gov"><a rel="nofollow" class="external text" href="https://comptox.epa.gov/dashboard/chemical/details/DTXSID70214011">DTXSID70214011</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q27280296#P3117" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></span></li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Chemical and physical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Chemical_formula" title="Chemical formula">Formula</a></th><td class="infobox-data"><span title="Carbon">C</span><sub>15</sub><span title="Hydrogen">H</span><sub>24</sub><span title="Nitrogen">N</span><sub>4</sub><span title="Oxygen">O</span><sub>6</sub></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Molar_mass" title="Molar mass">Molar mass</a></th><td class="infobox-data"><span class="nowrap"><span data-sort-value="7002356379000000000♠"></span>356.379</span> g·mol<sup>−1</sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">3D model (<a href="/wiki/JSmol" class="mw-redirect" title="JSmol">JSmol</a>)</th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="chemapps.stolaf.edu (3D interactive model)"><a rel="nofollow" class="external text" href="https://chemapps.stolaf.edu/jmol/jmol.php?model=CC%28C%29%5BC%40%40H%5D%28C%28%3DO%29O%5BC%40%40H%5D1%5BC%40H%5D%28O%5BC%40H%5D%28%5BC%40%5D1%28C%29O%29N2C%3DCC%28%3DNC2%3DO%29N%29CO%29N">Interactive image</a></span></li></ul></div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/Simplified_molecular-input_line-entry_system" class="mw-redirect" title="Simplified molecular-input line-entry system">SMILES</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">CC(C)[C@@H](C(=O)O[C@@H]1[C@H](O[C@H]([C@]1(C)O)N2C=CC(=NC2=O)N)CO)N</div></li></ul> </div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/International_Chemical_Identifier" title="International Chemical Identifier">InChI</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">InChI=1S/C15H24N4O6/c1-7(2)10(17)12(21)25-11-8(6-20)24-13(15(11,3)23)19-5-4-9(16)18-14(19)22/h4-5,7-8,10-11,13,20,23H,6,17H2,1-3H3,(H2,16,18,22)/t8-,10+,11-,13-,15-/m1/s1</div></li><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">Key:TVRCRTJYMVTEFS-ICGCPXGVSA-N</div></li></ul> </div></td></tr></tbody></table> <p><b>Valopicitabine</b> (<b>NM-283</b>) is an <a href="/wiki/Antiviral_drug" title="Antiviral drug">antiviral drug</a> which was developed as a treatment for <a href="/wiki/Hepatitis_C" title="Hepatitis C">hepatitis C</a>, though only progressed as far as Phase III <a href="/wiki/Clinical_trial" title="Clinical trial">clinical trials</a>. It acts as an RNA-dependent <a href="/wiki/RNA_polymerase" title="RNA polymerase">RNA polymerase</a> inhibitor. It is a <a href="/wiki/Prodrug" title="Prodrug">prodrug</a> which is converted inside the body to the active form, 2'-C-methylcytidine triphosphate.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Valopicitabine&action=edit&section=1" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-1">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFPierraBenzariaAmadorMoussa2005" class="citation journal cs1">Pierra C, Benzaria S, Amador A, Moussa A, Mathieu S, Storer R, Gosselin G (2005). 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"Amino Acid Ester Prodrugs of Nucleoside and Nucleotide Antivirals". <i>Mini Reviews in Medicinal Chemistry</i>. <b>17</b> (10): 818–833. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.2174%2F1389557517666170216151601">10.2174/1389557517666170216151601</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/28215138">28215138</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Mini+Reviews+in+Medicinal+Chemistry&rft.atitle=Amino+Acid+Ester+Prodrugs+of+Nucleoside+and+Nucleotide+Antivirals&rft.volume=17&rft.issue=10&rft.pages=818-833&rft.date=2017&rft_id=info%3Adoi%2F10.2174%2F1389557517666170216151601&rft_id=info%3Apmid%2F28215138&rft.aulast=Krecmerova&rft.aufirst=M&rfr_id=info%3Asid%2Fen.wikipedia.org%3AValopicitabine" class="Z3988"></span></span> </li> </ol></div></div> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl 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template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:RNA_antivirals" title="Template talk:RNA antivirals"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:RNA_antivirals" title="Special:EditPage/Template:RNA antivirals"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="RNA_virus_antivirals_(primarily_J05,_also_S01AD_and_D06BB)" style="font-size:114%;margin:0 4em"><a href="/wiki/RNA_virus" title="RNA virus">RNA virus</a> <a href="/wiki/Antiviral_drug" title="Antiviral drug">antivirals</a> (primarily <a href="/wiki/ATC_code_J05" title="ATC code J05">J05</a>, also <a href="/wiki/ATC_code_S01#S01AD" title="ATC code S01">S01AD</a> and <a href="/wiki/ATC_code_D06#D06BB" title="ATC code D06">D06BB</a>)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Hepatitis_C" title="Hepatitis C">Hepatitis C</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/NS3_(HCV)" class="mw-redirect" title="NS3 (HCV)">NS3</a>/<a href="/wiki/NS4A" class="mw-redirect" title="NS4A">4A</a> protease inhibitors (–previr)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Asunaprevir" title="Asunaprevir">Asunaprevir</a></li> <li><a href="/wiki/Boceprevir" title="Boceprevir">Boceprevir</a><sup><b>‡</b></sup></li> <li><a href="/wiki/Ciluprevir" title="Ciluprevir">Ciluprevir</a><sup><b>§</b></sup></li> <li><a href="/wiki/Danoprevir" title="Danoprevir">Danoprevir</a><sup><b>†</b></sup></li> <li><a href="/wiki/Faldaprevir" title="Faldaprevir">Faldaprevir</a><sup><b>‡</b></sup></li> <li><a href="/wiki/Glecaprevir" title="Glecaprevir">Glecaprevir</a></li> <li><a href="/wiki/Grazoprevir" title="Grazoprevir">Grazoprevir</a></li> <li><a href="/wiki/Narlaprevir" title="Narlaprevir">Narlaprevir</a></li> <li><a href="/wiki/Paritaprevir" title="Paritaprevir">Paritaprevir</a></li> <li><a href="/wiki/Simeprevir" title="Simeprevir">Simeprevir</a></li> <li><a href="/wiki/Sovaprevir" title="Sovaprevir">Sovaprevir</a><sup><b>†</b></sup></li> <li><a href="/wiki/Telaprevir" title="Telaprevir">Telaprevir</a><sup><b>‡</b></sup></li> <li><a href="/wiki/Vaniprevir" title="Vaniprevir">Vaniprevir</a></li> <li><a href="/w/index.php?title=Vedroprevir&action=edit&redlink=1" class="new" title="Vedroprevir (page does not exist)">Vedroprevir</a><sup><b>§</b></sup></li> <li><a href="/wiki/Voxilaprevir" title="Voxilaprevir">Voxilaprevir</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/NS5A" class="mw-redirect" title="NS5A">NS5A</a> inhibitors (–asvir)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Coblopasvir" title="Coblopasvir">Coblopasvir</a></li> <li><a href="/wiki/Daclatasvir" title="Daclatasvir">Daclatasvir</a><sup><b>#</b></sup></li> <li><a href="/wiki/Elbasvir" title="Elbasvir">Elbasvir</a></li> <li><a href="/wiki/Ledipasvir" title="Ledipasvir">Ledipasvir</a></li> <li><a href="/wiki/Odalasvir" title="Odalasvir">Odalasvir</a><sup><b>†</b></sup></li> <li><a href="/wiki/Ombitasvir" title="Ombitasvir">Ombitasvir</a></li> <li><a href="/wiki/Pibrentasvir" title="Pibrentasvir">Pibrentasvir</a></li> <li><a href="/wiki/Ravidasvir" title="Ravidasvir">Ravidasvir</a><sup><b>†</b></sup></li> <li><a href="/w/index.php?title=Ruzasvir&action=edit&redlink=1" class="new" title="Ruzasvir (page does not exist)">Ruzasvir</a><sup><b>†</b></sup></li> <li><a href="/wiki/Samatasvir" title="Samatasvir">Samatasvir</a><sup><b>†</b></sup></li> <li><a href="/wiki/Velpatasvir" title="Velpatasvir">Velpatasvir</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/NS5B" class="mw-redirect" title="NS5B">NS5B</a> <a href="/wiki/RNA_polymerase" title="RNA polymerase">RNA polymerase</a> inhibitors (–buvir)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Beclabuvir" title="Beclabuvir">Beclabuvir</a><sup><b>†</b></sup></li> <li><a href="/wiki/Bemnifosbuvir" title="Bemnifosbuvir">Bemnifosbuvir</a><sup><b>†</b></sup></li> <li><a href="/wiki/Dasabuvir" title="Dasabuvir">Dasabuvir</a><sup><b>#</b></sup></li> <li><a href="/wiki/Deleobuvir" title="Deleobuvir">Deleobuvir</a><sup><b>§</b></sup></li> <li><a href="/wiki/Filibuvir" title="Filibuvir">Filibuvir</a><sup><b>§</b></sup></li> <li><a href="/wiki/GS-6620" title="GS-6620">GS-6620</a><sup><b>§</b></sup></li> <li><a href="/wiki/IDX-184" title="IDX-184">IDX-184</a><sup><b>§</b></sup></li> <li><a href="/wiki/Setrobuvir" title="Setrobuvir">Setrobuvir</a><sup><b>§</b></sup></li> <li><a href="/wiki/Sofosbuvir" title="Sofosbuvir">Sofosbuvir</a><sup><b>#</b></sup></li> <li><a href="/w/index.php?title=Tegobuvir&action=edit&redlink=1" class="new" title="Tegobuvir (page does not exist)">Tegobuvir</a><sup><b>§</b></sup></li> <li><a href="/wiki/TMC-647055" title="TMC-647055">TMC-647055</a><sup><b>§</b></sup></li> <li><a href="/wiki/Radalbuvir" title="Radalbuvir">Radalbuvir</a><sup><b>†</b></sup></li> <li><a href="/wiki/Uprifosbuvir" title="Uprifosbuvir">Uprifosbuvir</a><sup><b>†</b></sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Combination drugs</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Elbasvir/grazoprevir" title="Elbasvir/grazoprevir">Elbasvir/grazoprevir</a></li> <li><a href="/wiki/Glecaprevir/pibrentasvir" title="Glecaprevir/pibrentasvir">Glecaprevir/pibrentasvir</a></li> <li><a href="/wiki/Ledipasvir/sofosbuvir" title="Ledipasvir/sofosbuvir">Ledipasvir/sofosbuvir</a><sup><b>#</b></sup></li> <li><a href="/wiki/Ombitasvir/paritaprevir/ritonavir" title="Ombitasvir/paritaprevir/ritonavir">Ombitasvir/paritaprevir/ritonavir</a><sup><b>#</b></sup></li> <li><a href="/wiki/Sofosbuvir/daclatasvir" title="Sofosbuvir/daclatasvir">Sofosbuvir/daclatasvir</a></li> <li><a href="/wiki/Sofosbuvir/velpatasvir" title="Sofosbuvir/velpatasvir">Sofosbuvir/velpatasvir</a><sup><b>#</b></sup></li> <li><a href="/wiki/Sofosbuvir/velpatasvir/voxilaprevir" title="Sofosbuvir/velpatasvir/voxilaprevir">Sofosbuvir/velpatasvir/voxilaprevir</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Hepatitis_D" title="Hepatitis D">Hepatitis D</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Bulevirtide" title="Bulevirtide">Bulevirtide</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Picornavirus" title="Picornavirus">Picornavirus</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Viral_entry" title="Viral entry">viral entry</a>:</i> <a href="/wiki/Pleconaril" title="Pleconaril">Pleconaril</a><sup><b>†</b></sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Anti-<a href="/wiki/Influenza" title="Influenza">influenza</a> agents</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Baloxavir_marboxil" title="Baloxavir marboxil">Baloxavir marboxil</a></li> <li><a href="/wiki/Pimodivir" title="Pimodivir">Pimodivir</a><sup><b>†</b></sup></li> <li><a href="/wiki/Umifenovir" title="Umifenovir">Umifenovir</a></li></ul> <ul><li><i><a href="/wiki/Adamantane" title="Adamantane">adamantane derivatives</a>/<a href="/wiki/M2_protein" class="mw-redirect" title="M2 protein">M2 inhibitors</a></i> (<a href="/wiki/Adapromine" title="Adapromine">Adapromine</a></li> <li><a href="/wiki/Amantadine" title="Amantadine">Amantadine</a></li> <li><a href="/wiki/Rimantadine" title="Rimantadine">Rimantadine</a>)</li></ul> <ul><li><i><a href="/wiki/Neuraminidase_inhibitor" title="Neuraminidase inhibitor">neuraminidase inhibitors</a>/<a href="/wiki/Antiviral_drug#Release_phase" title="Antiviral drug">release phase</a></i> (<a href="/wiki/Oseltamivir" title="Oseltamivir">Oseltamivir</a><sup><b>#</b></sup></li> <li><a href="/wiki/Zanamivir" title="Zanamivir">Zanamivir</a></li> <li><a href="/wiki/Peramivir" title="Peramivir">Peramivir</a>, <a href="/wiki/Laninamivir" title="Laninamivir">Laninamivir</a><sup><b>†</b></sup>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Multiple/general</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Interferon" title="Interferon">Interferon</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interferon_alfa_2b" class="mw-redirect" title="Interferon alfa 2b">Interferon alfa 2b</a></li> <li><a href="/wiki/Peginterferon_alfa-2a" title="Peginterferon alfa-2a">Peginterferon alfa-2a</a><sup><b>#</b></sup></li> <li><a href="/wiki/Peginterferon_alfa-2b" title="Peginterferon alfa-2b">Peginterferon alfa-2b</a><sup><b>#</b></sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/3C-like_protease" title="3C-like protease">3CL protease</a> inhibitors (–trelvir)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Ensitrelvir" title="Ensitrelvir">Ensitrelvir</a><sup><b>†</b></sup></li> <li><a href="/wiki/Ibuzatrelvir" title="Ibuzatrelvir">Ibuzatrelvir</a></li> <li><a href="/wiki/Lufotrelvir" title="Lufotrelvir">Lufotrelvir</a></li> <li><a href="/wiki/Nirmatrelvir" title="Nirmatrelvir">Nirmatrelvir</a><sup><b>†</b></sup> (<a href="/wiki/Nirmatrelvir/ritonavir" title="Nirmatrelvir/ritonavir">+ritonavir</a>)<sup><b>†</b></sup></li> <li><a href="/wiki/Rupintrivir" title="Rupintrivir">Rupintrivir</a></li> <li><a href="/wiki/Simnotrelvir" class="mw-redirect" title="Simnotrelvir">Simnotrelvir</a> (<a href="/wiki/Simnotrelvir/ritonavir" title="Simnotrelvir/ritonavir">+ritonavir</a><sup><b>†</b></sup>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">RNA pol inhibitors</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CMX521" title="CMX521">CMX521</a><sup><b>§</b></sup></li> <li><a href="/wiki/Deuremidevir" title="Deuremidevir">Deuremidevir</a><sup><b>†</b></sup></li> <li><a href="/wiki/Favipiravir" title="Favipiravir">Favipiravir</a></li> <li><a href="/wiki/Galidesivir" title="Galidesivir">Galidesivir</a><sup><b>†</b></sup></li> <li><a href="/wiki/GS-441524" title="GS-441524">GS-441524</a><sup><b>§</b></sup></li> <li><a href="/wiki/Remdesivir" title="Remdesivir">Remdesivir</a></li> <li><a href="/wiki/MK-608" title="MK-608">MK-608</a><sup><b>§</b></sup></li> <li><a href="/wiki/Mericitabine" title="Mericitabine">Mericitabine</a><sup><b>†</b></sup></li> <li><a href="/wiki/Molnupiravir" title="Molnupiravir">Molnupiravir</a></li> <li><a href="/wiki/NITD008" title="NITD008">NITD008</a><sup><b>§</b></sup></li> <li><a href="/wiki/Ribavirin" title="Ribavirin">Ribavirin</a><sup><b>#</b></sup></li> <li><a href="/wiki/Taribavirin" title="Taribavirin">Taribavirin</a><sup><b>†</b></sup></li> <li><a href="/wiki/Triazavirin" class="mw-redirect" title="Triazavirin">Triazavirin</a></li> <li><a class="mw-selflink selflink">Valopicitabine</a><sup><b>†</b></sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Multiple/Unknown/Other</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/EICAR_(antiviral)" title="EICAR (antiviral)">EICAR</a><sup><b>§</b></sup></li> <li><a href="/wiki/Merimepodib" title="Merimepodib">Merimepodib</a><sup><b>§</b></sup></li> <li><a href="/wiki/Moroxydine" title="Moroxydine">Moroxydine</a></li> <li><a href="/wiki/Presatovir" title="Presatovir">Presatovir</a><sup><b>†</b></sup></li></ul> 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