CINXE.COM
Just a moment...
<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "pubs.acs.org",cType: 'managed',cRay: '8e9433dc6a789fa4',cH: 'HYGxGqdlWx_Q9G4Qs2aXbNoXCkPZSW7ex1Ql2wArDsw-1732732364-1.2.1.1-hiJSPMynEuyaKSiA5yQgp73aJR6pqbmPnup7ci_w88IJ6cBErNx4FXf1pF2F6dHR',cUPMDTk: "\/doi\/abs\/10.1021\/cr0300892?journalCode=chreay&__cf_chl_tk=HG51r.Dlvdx3SeLMMdHC553Uus.EOmhVXg2d_oH9NQ4-1732732364-1.0.1.1-cOklWGpFMw75YVn3L6fv7w45PCLMIEgBXPzY2kNVMv8",cFPWv: 'b',cITimeS: '1732732364',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/doi\/abs\/10.1021\/cr0300892?journalCode=chreay&__cf_chl_f_tk=HG51r.Dlvdx3SeLMMdHC553Uus.EOmhVXg2d_oH9NQ4-1732732364-1.0.1.1-cOklWGpFMw75YVn3L6fv7w45PCLMIEgBXPzY2kNVMv8",md: "LMCfIpAxnjB2dLWz5XOYWQL6YQK5UR9bXP2i6SaT9Ug-1732732364-1.2.1.1-UvZudnxp0mwfUw2dmOInpuidvki3BXUWb1D.tX3sjVO31BQKiOr_1UIgc.9M_JIPKQvpXQaxx1HKzQRBB3pg_fhiSmQPlOLl7c62xl7zg1Ww35R6FpqNR7wrPD.yJpxprYMSY7wK1N4lESPs4e8yRlubvgyrS3nLADhWj4Wl.5IiScxcUFazO63c5G6RmUt1EzzzP0V99DQ2SeV4c6w0QF.hX6MDGwzgsPivuAyyI4fF8skvNeQHyRHq2ioDXfWyysvFdik_81H5rYQveTldhcI2Dj6cMiZ3jOrlgTR0gluXQsRYDB7H6CV3FV2BWc5AMpxiCaYoaCQSmg_HhnLBV1XIy.oxlyyQY8L8t3Pg3XWbeo2hMI0xHRarCNEvHL8KavSUl7k1soShZdPKfkVuZBYoK0sTyUYvSJPxF8BgzaAupb.tq37v7XFtyVLyh5tOrqwobJnXEM7RBIe9p2QOiEm9nogxygV.6KlTe8oLt_BNe.6hGIjTmp1X5zIWaFs4CaaTwbsoHlgmtRapSyqHhhJatg788WGsq3iSKYKgbg.Gn012G2vGfkYIBw0t5sE79rzjxC_udCLb3lbfAR2W7rmhYCLcswLIb3y1JYdVHT_TAl4ApgK2kdqQFj.f.PqKBi8_LwAWWP8ms7h6AUAJM9yXVUrIlvqcRQFNHOSrhj5zPEm2LYIRrGW_TyjvQ7tJFq8TbQbKtKiKPxKwKBf2PcHYa3Si1tr1RJkVPQTvNM6IjH.DOJD3s0oN0pi6wdiWWNnfLX8MjJyl8aYownY0OpFl7BNFYnN84Hq8i4VoYJDRsewlWFuHnyMNizQu1GTZ9Upud9BHbTKz1ha_naP09AXzHoxEO3Ften7YaCHI8XjJczY7Ch3jfvDuIGEW0qhlwuyOZuMYHUdyRJEwEiLu1aT2XmNTG45I5y6p_igxobDKyXn5Eehbj0I1g8.xr_qMI5MWK1yxDI1y7H9Z1hEPcKl2xzZNEyfojIleknqIykVO0Sll91kDjrmnsKCOX1Hx7dfnI3bUyCUVhscr2BLYgTWvcOUtZnfOAIy_1E17X5kL.GKrhzq0yjMbzdT5jI1K1OP3O7d7ZSRUhlCGVZYxJaYdPWfV3LzRD0gKD9VK7tB6RG2_1GD8C1MTmza5W4YYcQ8fcW62a9yUOxaT_6PuV6IS.24NMRub5ziG1N2nx9P2on1ZlVRA8hdjWFR3h8pABkxjOmwTb_i9lcFnCWQCpwxjY31DBt.XRkfDo_llr9XbG2plX3Kmy7NtNPksM470JlPU8dL8IqLMOHCDYJIbuTWm3lMXZm0ZmLv6SSvSCDKei3fl9keYzAKKtQE8VpzRzHBJV_1f1HGIpBE2O1TAS_ygitVFtUN4ygDmLwDD7oS6CS9aTj8Q.Ph7yx1wF.Nbu2M8uezWPzRtra1I6tTbRjvEUkX02icKpAMWJFFQFZXgDQagHUP2Q7Js0ZvIbn5QDdpbiOS2PbADUtcZXUbe5mw7PkAP8i9ihYKBKefWEnSzqjsbVNq7qMgnWxVJt3Bk32S65AGz1fIqwlpJduZU3viLurWSQUmi8Sxsxodpy9ospcswG2EkT67dn8KMVkqfHyKohNHNQLBf4DMZhOVmSFzdzjDHx5zDZiCGs1gmaqobx9tjf_mCxqhtPYL6jceuWsQDYyh2z3cCTPZG13BXnLKvdF9ngh5iyPCInYVFxSD_021q33rcwOuzQjTGO7gONnkUVis87h4KXjw25NyF3wmgHTXj4eVNRD_M5GXmmCl1ARmpM_.MuvbQAVXb2.6O9knYHUdvAYh6vvGXXjH6SJHpaS2XhptaB26M7c6CdtSfAin0v9VMx39U3LkPXezZSsmkkvYyUtJFTnGj6nCB6z35R3uxkNpPD6QYQBif1gq0R.BSo3T4Sk.E.r3OWGGzxVYFalYP8d7UnvtmHeiMfPYN9bFyhnyptEFxWXgmuaMV41hieTSkMTnUvqfmALvpuBPFPR_hoG7OdKp3DdMzsamuxiC1U4wmYcd708BhgVq4.H5L72hvoGCsbhWK.vTJ8d5bxyrhk6t0RmQTuuVGVHsS78wo26ZPHl9XL7_cS9Nk4fv0deFdsU2iidV.hcKGtio4iEyAraNHh..stpMvlTWMQLDiTrxUcAvgjKAXMZYCQiWa.QIZ_L.oSlquinJYLsZnObi.6FhfKMjj2GXJHip7mQp6vt78qifp2s0dzqffEj1kWkNmvF.BPc0G1z_p5.wBhWkRPPdx0JecJT3ZMqCQ8fdl8GqyFJfoCDo8KFCVXukJADJb.d17JlcjNBtlifx4.JQIxZ5N7xpHZlRjDVinY_G.gSJkuUMDX7CdixcailnkKUN7BpFtWZSgf4xGeppFBZYN5OMfDSWbyEpt4UrZbR4k18tNJdgdrcrXoRlOaOG_4F5S2EHxTDVS4cgMZLodEg7xGcthfAFGohPgm_pGzq_a4DJhX3EMoPPw4.B_IlsIv8xtrOkzVBVexzIYxLuQU2uFiiRi06tSTyZNMZpWntuJ735QMlSpZLjUwjj8rXGBPAS4UHv6OZDV0ecHyGQZXO1mg2wDSbDiawuCEkdxN5bmatOZCwnmv0kcbeu1AV3lYrsurPpUiXce8B04VQAxy4Gcfndac5j0thIGPrCcutCSKbz3FLyJ4jpbig6QqNwcEa_qR.oiANPYP1ovo_yY55DzShBL6VUI2iHbOKdOQ_89L9i3QFEq5sRuvc7sb8CS1uPAXyZuHyh0GxCNeqUKkhuEndEzqjeP.rOErfU0dsffTsLQmrzTyamfU67FVcHX4pBTx7jKhLlvbGo4XpIJKqmt4foqx6UXN9.3_._zU4IbkT0o2H.GrhUn1lLiHf_Bf0Wx26jqycTJSUIFaon34MCeFvzXO2j4LrNnZILE97.ZLCzQWUAhZwLGMULNnqiw1kqyQeFeXIa.qw57wHTYq7DT51bZ5mdw_xvTbhN4EluWip6oun..atWTCjPmva35GDP2lPd0dK4qoRPt4b03Ko51hdHFphE3ezyU3g",mdrd: "Pmv6YrUJYRm8m2IRNsaUQWVvD9R.1hcmnRIobxqLLqM-1732732364-1.2.1.1-V4NRHgHUPXnRtcZHsRA3TOMeOYQgn6RuS8qKF2b1.FNen3h8iu7joH7LZNobwalgEDl6EQRf5QfeA9Yetpmcmm8oAgT1esushJEXMAxaI.Y.WU5fxI5I2ZqTPyPLz6x3SIP1CtVNtS3Opqqh.9bQXcILop5_S_rBk2fLNY0VT47hDl7m7D1ET1m2HugReIZgwVN65bne_VliA9sO6G6J_aAis2ULdCXor50Q5nFGDHKddBPVY_ORalLyVFujkttWldvBPwlFgM7_8UfC1XFEfU0bjZ_d.hIIRxP3ZlS7hVTgH67QMLjCDQtl6bsW6cqI0BBNtQJME6w2OKCnBTmBph98Yw4NxgIhLP.B2I0W2WRKR7RJImD_uDol.tqFHdk6OEItHM46xjUA7O8PVFJtrfx5xH1fV8UV3bRUfEE4ZURuUtNMARhrDcOq9Uu0z5aA2OcPm4rbNCMW0_YgDVjA19aBgyqxxh_A1cpJHxl0TpEUsmFvlX.Gckl52n7uJXIPS43qqFkIzVySJX4l1flOzgeQE9GRoNmaiMWXSlire.D1egQadHnJUOcb86AJJb5IYZKpzBpiA8z0_ITbFwCRQnXA6c6FR34vYBoGWWYS4EG6v30udT7Vyc9E3If_J9lamDw6gSt8YNWilXl8znDlCpoD8LuPx0pMYE0NIitII9QIhn.7IrJ63y9v9pTr3X66NqLwyJE2WgJpLR6Z_kP0wgbGqh.5YmySaZ10JleSQgyXmIWj34F2384Go7mPIEMWbioq9ntl0Y.DB2Ebk16khYOLCX_.i8tH.ZIbfnADvQbwtDsR5.lxauFmXztns2Y.lwPwN7tFL9.43wDX0VyLiw5nJKtKBB6y27YdYHaevl.SZk.mhMKcTl4hq9OypMGo_.A5yi1kNQW_m.ChiSmniz1zhc_WkTLojuCiJAbN7X_VkTXVP8Tc4ZdMawhrql7c9JcOQ7_CFPPpxm1AVvDymmx7eTus86dGPuAXOKn.OEm_XjFJkpqFqCcmcGqvhZ52vQ_5OgzSr_kfB30CbmiQdyKf_0junmH3PUeV6SI2gA1mkxukwHNIFqT037R7Vvsm0ufL7iHNDNocAy4WWMHexIkKez5qMCyp.iRb0m7VxkXme1OmzZ2NUnDaHUn99D5DQHC061Ut0S1o5gXKnZpz.Am3jjq_DCuyKVLPr7XI7krmmjxsgT9ENzv3GzPcfR1q5Aw9yXgXZ1oVgMNuJuuPCsKCSzKhDde_Oxsr_cT.RqGJevD8BNl1d1IEvJ5WwDwNQ3511BuLAWpCYv1IPGhjH50JZEaAZCAkNZa380UliFIYWcJKS69u2mMx_6_y5hox56rjTvP_Ti7_fiT4b9_MUNFbRxh_3h.zloIkSY3IrCyhHiHFi6ReFPmCg7ECJjyONPl5sTofoJnDAiRDNaL7JgoiNfdn55edoi3AvUj.vHSRa3b1JwC4LE8cxWvoRojr_HOOY5SaZ.aM.DEpI.k0Oc6RajFiREoexE8s0lKvFJSueO0DdLQ_oi5eirPYqkZUCxN_QkejPN.5sw9gbvmXpyba8aLcOXzKUoi_eJA0O8BFofcYCUKKPx2IhXa3kRNu.wH_I4VuYNP5SbRw9r2Gpieur7VLZhlxJCDYiXpObmcjifSHxrzsVNAlcAEQ9n0vdOCW0QQrM.KU7ItLv7M29FHes_nmB0TUItskKD_2jcWg5ycdvPGn_TJOLQCBdxng.rVfX35fQCEx4ZG.VACmYXYp6.GCZO9I8xbRn64Zr3Q_vrdxzpyXe_KRMEBHOBWcHmoN2LwxWQNCbLoIv5LYvC0vducKAgP2K9TVeRFAD86bY0SpFLcYrqiTm1DRJBOaMYX1U0KsO9wrmqHE3H_F2EoE8s7dAMjvfIqkA1pM2Ql9Kch0XroabIXfiOz9NgWgxV9nb1oL_NIBGSsWUtr5kAVeEh7xdGOMVkZhTbYkAjIVV8gyfTsf9eL1_5Azmix9"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/b/orchestrate/chl_page/v1?ray=8e9433dc6a789fa4';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/doi\/abs\/10.1021\/cr0300892?journalCode=chreay&__cf_chl_rt_tk=HG51r.Dlvdx3SeLMMdHC553Uus.EOmhVXg2d_oH9NQ4-1732732364-1.0.1.1-cOklWGpFMw75YVn3L6fv7w45PCLMIEgBXPzY2kNVMv8" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>