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(PDF) Severe acute pancreatitis admitted to intensive care unit: SOFA is superior to Ranson's criteria and APACHE II in determining prognosis
<!DOCTYPE html> <html > <head> <meta charset="utf-8"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <meta content="width=device-width, initial-scale=1" name="viewport"> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs"> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="_zH7keUGrHjIesbQH_EYwmARJF8DQ0LPdutdgSt5DGZSzhmhz2xHCwxG1SRhicv8g3FeMAZYSKcXQj-vMso_2g" /> <meta name="citation_title" content="Severe acute pancreatitis admitted to intensive care unit: SOFA is superior to Ranson&#39;s criteria and APACHE II in determining prognosis" /> <meta name="citation_publication_date" content="2013/01/01" /> <meta name="citation_journal_title" content="The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology" /> <meta name="citation_author" content="Ilkin Cankayali" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:url" content="https://www.academia.edu/60278393/Severe_acute_pancreatitis_admitted_to_intensive_care_unit_SOFA_is_superior_to_Ransons_criteria_and_APACHE_II_in_determining_prognosis" /> <meta name="twitter:title" content="Severe acute pancreatitis admitted to intensive care unit: SOFA is superior to Ranson's criteria and APACHE II in determining prognosis" /> <meta name="twitter:description" content="Severe acute pancreatitis usually requires intensive management of cardiovascular, pulmonary, renal, and septic complications. Many scoring systems are used in determining the outcomes. The aim of the study was to evaluate the role of three scoring" /> <meta name="twitter:image" content="http://a.academia-assets.com/images/twitter-card.jpeg" /> <meta property="fb:app_id" content="2369844204" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.academia.edu/60278393/Severe_acute_pancreatitis_admitted_to_intensive_care_unit_SOFA_is_superior_to_Ransons_criteria_and_APACHE_II_in_determining_prognosis" /> <meta property="og:title" content="Severe acute pancreatitis admitted to intensive care unit: SOFA is superior to Ranson's criteria and APACHE II in determining prognosis" /> <meta property="og:image" content="http://a.academia-assets.com/images/open-graph-icons/fb-paper.gif" /> <meta property="og:description" content="Severe acute pancreatitis usually requires intensive management of cardiovascular, pulmonary, renal, and septic complications. Many scoring systems are used in determining the outcomes. The aim of the study was to evaluate the role of three scoring" /> <meta property="article:author" content="https://independent.academia.edu/IlkinCankayali" /> <meta name="description" content="Severe acute pancreatitis usually requires intensive management of cardiovascular, pulmonary, renal, and septic complications. Many scoring systems are used in determining the outcomes. The aim of the study was to evaluate the role of three scoring" /> <title>(PDF) Severe acute pancreatitis admitted to intensive care unit: SOFA is superior to Ranson's criteria and APACHE II in determining prognosis</title> <link rel="canonical" href="https://www.academia.edu/60278393/Severe_acute_pancreatitis_admitted_to_intensive_care_unit_SOFA_is_superior_to_Ransons_criteria_and_APACHE_II_in_determining_prognosis" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = 'a68ca24ef94e14dff4960a9c79b38817761055c5'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1740154262000); window.Aedu.timeDifference = new Date().getTime() - 1740154262000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"Severe acute pancreatitis usually requires intensive management of cardiovascular, pulmonary, renal, and septic complications. Many scoring systems are used in determining the outcomes. The aim of the study was to evaluate the role of three scoring systems, i.e. Acute Physiology and Chronic Health Evaluation, Sequential Organ Failure Assessment, and modified Ranson\u0026amp;amp;#39;s criteria, in predicting mortality rate in patients with severe acute pancreatitis as well as other factors influencingmortality in patients admitted to intensive care unit. Charts of 43 patients hospitalized in intensive care unit with severe acute pancreatitis were screened retrospectively. Four patients were excluded. Acute Physiology and Chronic Health Evaluation II, Sequential Organ Failure Assessment and modified Ranson\u0026amp;amp;#39;s scores were calculated on admission, and Sequential Organ Failure Assessment score was recorded on weekly intervals during the intensive care unit stay. Thirty-nine patients were included ...","author":[{"@context":"https://schema.org","@type":"Person","name":"Ilkin Cankayali","url":"https://independent.academia.edu/IlkinCankayali"}],"contributor":[],"dateCreated":"2021-10-29","dateModified":"2021-10-29","datePublished":"2013-01-01","headline":"Severe acute pancreatitis admitted to intensive care unit: SOFA is superior to Ranson's criteria and APACHE II in determining prognosis","image":"https://attachments.academia-assets.com/73795412/thumbnails/1.jpg","inLanguage":"en","keywords":["Pancreatitis","Humans","Female","Male","Young Adult","Apache","Aged","Middle Aged","Adult","Retrospective Studies","Prognosis","Intensive Care Units","Hospital Mortality","Severity of Illness Index","Acute Disease","health status indicators"],"publication":"The Turkish journal of gastroenterology : the official journal of Turkish Society of 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"https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F60278393%2FSevere_acute_pancreatitis_admitted_to_intensive_care_unit_SOFA_is_superior_to_Ransons_criteria_and_APACHE_II_in_determining_prognosis%3Fshow_translation%3Dtrue"; window.loswp.previewableAttachments = [{"id":73795412,"identifier":"Attachment_73795412","shouldShowBulkDownload":false}]; window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":60278393,"created_at":"2021-10-29T01:27:35.630-07:00","from_world_paper_id":182043242,"updated_at":"2022-05-08T07:09:53.007-07:00","_data":{"abstract":"Severe acute pancreatitis usually requires intensive management of cardiovascular, pulmonary, renal, and septic complications. Many scoring systems are used in determining the outcomes. The aim of the study was to evaluate the role of three scoring systems, i.e. Acute Physiology and Chronic Health Evaluation, Sequential Organ Failure Assessment, and modified Ranson\u0026#39;s criteria, in predicting mortality rate in patients with severe acute pancreatitis as well as other factors influencingmortality in patients admitted to intensive care unit. Charts of 43 patients hospitalized in intensive care unit with severe acute pancreatitis were screened retrospectively. Four patients were excluded. Acute Physiology and Chronic Health Evaluation II, Sequential Organ Failure Assessment and modified Ranson\u0026#39;s scores were calculated on admission, and Sequential Organ Failure Assessment score was recorded on weekly intervals during the intensive care unit stay. Thirty-nine patients were included ...","publication_date":"2013,,","publication_name":"The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Severe acute pancreatitis admitted to intensive care unit: SOFA is superior to Ranson's criteria and APACHE II in determining prognosis","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [39441536]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loginModal = {}; window.loginModal.appleClientId = 'edu.academia.applesignon'; window.userInChina = "false";</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":73795412,"attachmentType":"pdf"}"><img alt="First page of “Severe acute pancreatitis admitted to intensive care unit: SOFA is superior to Ranson's criteria and APACHE II in determining prognosis”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/73795412/mini_magick20211029-4420-1yf10i0.png?1635496150" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/images/single_work_splash/adobe_icon.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Severe acute pancreatitis admitted to intensive care unit: SOFA is superior to Ranson's criteria and APACHE II in determining prognosis</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="39441536" href="https://independent.academia.edu/IlkinCankayali"><img alt="Profile image of Ilkin Cankayali" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Ilkin Cankayali</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">2013, The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology</p><div class="ds-work-card--work-metadata"><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">visibility</span><p class="ds2-5-body-sm" id="work-metadata-view-count">…</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">description</span><p class="ds2-5-body-sm">6 pages</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">link</span><p class="ds2-5-body-sm">1 file</p></div></div><script>(async () => { const workId = 60278393; 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Many scoring systems are used in determining the outcomes. The aim of the study was to evaluate the role of three scoring systems, i.e. Acute Physiology and Chronic Health Evaluation, Sequential Organ Failure Assessment, and modified Ranson&#39;s criteria, in predicting mortality rate in patients with severe acute pancreatitis as well as other factors influencingmortality in patients admitted to intensive care unit. Charts of 43 patients hospitalized in intensive care unit with severe acute pancreatitis were screened retrospectively. Four patients were excluded. Acute Physiology and Chronic Health Evaluation II, Sequential Organ Failure Assessment and modified Ranson&#39;s scores were calculated on admission, and Sequential Organ Failure Assessment score was recorded on weekly intervals during the intensive care unit stay. 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Organ failure (OF) has been correlated with mortality in AP. Objectives: to evaluate the usefulness of APACHE II as an early predictor of severity in AP, its correlation with OF, and the relevance of an early establishment of OF during the course of AP. Patients and methods: from January 1999 to November 2001, 447 consecutive cases of AP were studied. APACHE II scores and Atlanta criteria were used for defining severity and OF. Results: twenty-five percent of patients had severe acute pancreatitis (SAP). APACHE II at 24 h after admission showed a sensitivity, specificity, and positive and negative predictive value of 52, 77, 46, and 84%, respectively, for predicting severity. Mortality for SAP was 20.5%. Seventy percent of patients who developed OF did so within the first 24 hours of admission, and their mortality was 52%. Mortality was statistically significant (p < 0.01) if OF was established within the first 24 hours after admission. Conclusions: APACHE II is not reliable for predicting outcome within the first 24 hours after admission and should therefore be used together with other methods. OF mostly develops within the first days after admission, if ever. The time of onset of OF is the most accurate and reliable method for predicting death risk in AP.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Early onset of organ failure is the best predictor of mortality in acute pancreatitis","attachmentId":110458787,"attachmentType":"pdf","work_url":"https://www.academia.edu/113520120/Early_onset_of_organ_failure_is_the_best_predictor_of_mortality_in_acute_pancreatitis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/113520120/Early_onset_of_organ_failure_is_the_best_predictor_of_mortality_in_acute_pancreatitis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="72364213" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/72364213/Audit_of_patients_with_severe_acute_pancreatitis_admitted_to_an_intensive_care_unit">Audit of patients with severe acute pancreatitis admitted to an intensive care unit</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="16100848" href="https://independent.academia.edu/AfzalAzim">Afzal Azim</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Indian Journal of Gastroenterology, 2012</p><p class="ds-related-work--abstract ds2-5-body-sm">Background Severe acute pancreatitis (SAP) is a disease with high morbidity and mortality. We undertook a study of patients with SAP admitted to the intensive care unit (ICU) of a tertiary referral hospital. Methods Between 2002 and 2007, 50 patients with SAP were admitted in our intensive care unit (ICU). Data were collected from their medical records and their clinical profile, course and outcome were retrospectively analyzed. Patients were categorized into survivor and nonsurvivor groups, and were further classified based on interventions such as percutaneous drainage and surgical necrosectomy. Results SAP contributed 5 % of total ICU admissions during the study period. Median age of survivors (n020) was 34 against 44 years in nonsurvivors (n030). Median Acute Physiology and Chronic Health Evaluation (APACHE) II score in nonsurvivors was 16.5 (8-32) vs. 12.5 (5-20) in survivors (p00.002). Patients with APACHE II score ≥12 had mortality >80 % compared to 23 % with score <12 (p<0.001). Median Sequential Organ Failure Assessment (SOFA) scores on admission and on days 3, 7, 14, and 21 were significantly higher in nonsurvivors compared to survivors (p<0.05). Mean (SD) intraabdominal pressure was 23 (3.37) mmHg in nonsurvivors vs. 19.05 (2.51) in survivors (p<0.05). Patients with renal failure had significant mortality (p<0.001). Length of ICU stay, requirement for vasopressor, total parenteral nutrition, and the amount of blood and blood product transfusions differed significantly between patients with and without intervention. Conclusions APACHE II and SOFA scores and other clinical data correlated with outcome in SAP admitted to ICU. Keywords Severe acute pancreatitis. Acute physiology and chronic health evaluation score. Sequential organ failure assessment score. Percutaneous drainage. Necrosectomy admission to intensive care unit (ICU). In this 5-year audit, we outline the demography, etiology, prognostic indices, severity, outcome, and interventions required for the management of severe AP (SAP) in a tertiary care medical surgical ICU, highlighting the resource-intensive nature of this catastrophic illness. Methods Data collection Data were collected from the medical records of the ICU of a tertiary care referral hospital in North India from 2002 to 2007, after prior approval from the Institute's ethics committee. We identified 50 consecutive patients with SAP out of the 1,015 patients admitted to our ICU during this period. Data from individual case records included age, sex, comorbid illness, etiology, and the duration of SAP. Admission variables included vitals (heart rate, respiratory rate, temperature, blood R.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Audit of patients with severe acute pancreatitis admitted to an intensive care unit","attachmentId":81319402,"attachmentType":"pdf","work_url":"https://www.academia.edu/72364213/Audit_of_patients_with_severe_acute_pancreatitis_admitted_to_an_intensive_care_unit","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/72364213/Audit_of_patients_with_severe_acute_pancreatitis_admitted_to_an_intensive_care_unit"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="74703006" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/74703006/Evaluation_of_prognostic_factors_in_patients_with_acute_pancreatitis">Evaluation of prognostic factors in patients with acute pancreatitis</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="40054116" href="https://policlinicogemelli.academia.edu/GBrisinda">G. Brisinda</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Hepato-Gastroenterology</p><p class="ds-related-work--abstract ds2-5-body-sm">The severity of acute pancreatitis is variable and does not always correlate with structural and functional changes in the pancreas. More precise predictors of severity are necessary to enable intensive therapy to be targeted at patients with severe attacks, and to judge efficacy of treatment, to help in the early detection of complications, and to facilitate comparison of patients from different centers. On admission, clinical criteria, biochemical and hematological parameters and multiple prognostic scores (Ranson, Imrie and APACHE-II scores) were collected from patients with acute pancreatitis. Two hundred and twenty-seven patients were seen during the study period. The overall mortality rate was 11.4%. A significantly higher mortality was found in patients with severe pancreatitis (25.8%) than in those with mild disease (1.5%, p=0.00001). Mortality was related to the presence of fever at admission (16.5% vs. 5.0%, p=0.006), and not to age, sex, etiological associations, or conco...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Evaluation of prognostic factors in patients with acute pancreatitis","attachmentId":82765274,"attachmentType":"pdf","work_url":"https://www.academia.edu/74703006/Evaluation_of_prognostic_factors_in_patients_with_acute_pancreatitis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/74703006/Evaluation_of_prognostic_factors_in_patients_with_acute_pancreatitis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="36918973" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/36918973/Comparison_of_Different_Scoring_System_in_Predicting_the_Severity_and_Prognosis_of_Acute_Pancreatitis">Comparison of Different Scoring System in Predicting the Severity and Prognosis of Acute Pancreatitis</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="65581038" href="https://independent.academia.edu/IOSRJDMS">IOSR JDMS</a></div><p class="ds-related-work--abstract ds2-5-body-sm">Introduction:Various prognostic scoring systems have been used, all aimed at predicting persistent organ failure, particularly respiratory, cardiac and renal. Severity stratification assessments should be performed in patients at 24 hours, 48 hours and 7 days after admission. Acute pancreatitis is one of the most common gastro-interological diseases. The annual incidence may range from 5-50/100000 populations worldwide. The disease may occur at any age, with peak in young man and older women. Objective:To determine the best prognostic indicator in acute pancreatitis comparing Ranson, Glasgow and Multiple organ system failure (MOSF) systems.To assess the prognostic accuracy of Ranson, Glasgow and Multiple Organ System Failure scoring systems in predicting the severity of acute pancreatitis. Materials and Methods:Hospital based prospective study carried out in Fishtail Hospital and Research Center Pvt. Ltd. in the period of 2 years of time (January 2016-December 2017). All patients presented to surgical out patients department (OPD) or emergency department who are diagnosed for acute pancreatitis were included. In this period total of 71 patients of acute pancreatitis were included in this study. All patients were examined and sent for laboratory investigations and radiological investigations required for the diagnosis. All statistical analysis was done using SPSS 11.5 software. Result:The mean age of thepatients was 52 years. There were female predominant. Alcohol was the most common causative agent. MOSF had maximum specificity of 100% followed by Glasgow 88% and Ranson 72%. Ranson had maximum sensitivity of 46 % followed by Glasgow 36% and MOSF 23%. MOSF had maximum positive predictable value 100% followed by Glasgow 78% and Ranson 67%. Conclusion:The present study show that MOSF score can determine the prognosis of acute pancreatitis early and it has highest specificity compared to Ranson and Glasgow.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Comparison of Different Scoring System in Predicting the Severity and Prognosis of Acute Pancreatitis","attachmentId":56869295,"attachmentType":"pdf","work_url":"https://www.academia.edu/36918973/Comparison_of_Different_Scoring_System_in_Predicting_the_Severity_and_Prognosis_of_Acute_Pancreatitis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/36918973/Comparison_of_Different_Scoring_System_in_Predicting_the_Severity_and_Prognosis_of_Acute_Pancreatitis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="32652814" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/32652814/Predicting_Acute_Pancreatitis_Severity_Comparison_of_Prognostic_Scores">Predicting Acute Pancreatitis Severity: Comparison of Prognostic Scores</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="9439500" href="https://enpc.academia.edu/PatriciaAlves">Patricia Alves</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Gastroenterology Research, 2011</p><p class="ds-related-work--abstract ds2-5-body-sm">Background: Acute pancreatitis has a broad clinical spectrum, from mild illness to multiple organ failure and death. Prognostic scores have been developed or adapted to predict disease severity. This study aimed to compare the prognostic scores according to sensitivity and specifi city, receiver operating characteristic curves and area under the curve. Statistical correlation with disease severity, length of hospital stay, mortality and complication rates.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Predicting Acute Pancreatitis Severity: Comparison of Prognostic Scores","attachmentId":52821334,"attachmentType":"pdf","work_url":"https://www.academia.edu/32652814/Predicting_Acute_Pancreatitis_Severity_Comparison_of_Prognostic_Scores","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/32652814/Predicting_Acute_Pancreatitis_Severity_Comparison_of_Prognostic_Scores"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="14998042" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/14998042/Predictors_of_severe_and_critical_acute_pancreatitis_A_systematic_review">Predictors of severe and critical acute pancreatitis: A systematic review</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33999954" href="https://independent.academia.edu/AnthonyhPhillips">Anthonyh Phillips</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Digestive and Liver Disease, 2014</p><p class="ds-related-work--abstract ds2-5-body-sm">Background: Persistent organ failure and infected pancreatic necrosis are major determinants of mortality in acute pancreatitis, but there is a gap in the literature assessing the best available predictors of these two determinants. The purpose of this review was to investigate the utility of predictors of persistent organ failure and infected pancreatic necrosis in patients with acute pancreatitis, both alone and in combination. Methods: We performed a systematic search of the literature in 3 databases for prospective studies evaluating predictors of persistent organ failure, infected pancreatic necrosis, or both, with strict eligibility criteria. Results: The best predictors of persistent organ failure were the Japanese Severity Score and Bedside Index of Severity in Acute Pancreatitis when the evaluation was performed within 48 h of admission, and blood urea nitrogen and Japanese Severity Score after 48 h of admission. Systemic Inflammation Response Syndrome was a poor predictor of persistent organ failure. The best predictor of infected pancreatic necrosis was procalcitonin. Conclusions: Based on the best available data, it is justifiable to use blood urea nitrogen for prediction of persistent organ failure after 48 h of admission and procalcitonin for prediction of infected pancreatic necrosis in patients with confirmed pancreatic necrosis. There is no predictor of persistent organ failure that can be justifiably used in clinical practice within 48 h of admission.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Predictors of severe and critical acute pancreatitis: A systematic review","attachmentId":43666368,"attachmentType":"pdf","work_url":"https://www.academia.edu/14998042/Predictors_of_severe_and_critical_acute_pancreatitis_A_systematic_review","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/14998042/Predictors_of_severe_and_critical_acute_pancreatitis_A_systematic_review"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="3733170" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/3733170/A_Prospective_Evaluation_of_the_Bedside_Index_for_Severity_in_Acute_Pancreatitis_Score_in_Assessing_Mortality_and_Intermediate_Markers_of_Severity_in_Acute_Pancreatitis">A Prospective Evaluation of the Bedside Index for Severity in Acute Pancreatitis Score in Assessing Mortality and Intermediate Markers of Severity in Acute Pancreatitis</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="4575144" href="https://independent.academia.edu/VikeshSingh">Vikesh Singh</a></div><p class="ds-related-work--metadata ds2-5-body-xs">American Journal of Gastroenterology, 2009</p><p class="ds-related-work--abstract ds2-5-body-sm">Our aim was to prospectively evaluate the ability of the bedside index for severity in acute pancreatitis (BISAP) score to predict mortality as well as intermediate markers of severity in a tertiary center.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A Prospective Evaluation of the Bedside Index for Severity in Acute Pancreatitis Score in Assessing Mortality and Intermediate Markers of Severity in Acute Pancreatitis","attachmentId":31410710,"attachmentType":"pdf","work_url":"https://www.academia.edu/3733170/A_Prospective_Evaluation_of_the_Bedside_Index_for_Severity_in_Acute_Pancreatitis_Score_in_Assessing_Mortality_and_Intermediate_Markers_of_Severity_in_Acute_Pancreatitis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/3733170/A_Prospective_Evaluation_of_the_Bedside_Index_for_Severity_in_Acute_Pancreatitis_Score_in_Assessing_Mortality_and_Intermediate_Markers_of_Severity_in_Acute_Pancreatitis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="25021705" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/25021705/Prediction_of_Mortality_in_Acute_Pancreatitis_A_Systematic_Review_of_the_Published_Evidence">Prediction of Mortality in Acute Pancreatitis: A Systematic Review of the Published Evidence</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="48143475" href="https://independent.academia.edu/DavidLloyd34">David Lloyd</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Pancreatology, 2009</p><p class="ds-related-work--abstract ds2-5-body-sm">proliferation of scoring systems for grading AP, none are ideal for the prediction of mortality. With the exception of the APACHE II, the other scores and indexes do not have a high degree of sensitivity, specificity and predictive values.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Prediction of Mortality in Acute Pancreatitis: A Systematic Review of the Published Evidence","attachmentId":45345980,"attachmentType":"pdf","work_url":"https://www.academia.edu/25021705/Prediction_of_Mortality_in_Acute_Pancreatitis_A_Systematic_Review_of_the_Published_Evidence","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/25021705/Prediction_of_Mortality_in_Acute_Pancreatitis_A_Systematic_Review_of_the_Published_Evidence"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="43962691" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/43962691/Marium_Saleem_et_al_Analysis_Of_Different_Outcomes_Patients_With_Acute_Pancreatitis_Requiring_Intensive_Care_Admission_Indo_Am">Marium Saleem et al, Analysis Of Different Outcomes Patients With Acute Pancreatitis Requiring Intensive Care Admission., Indo Am</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="15402473" href="https://nagajunauniversity.academia.edu/Editoriajps">Editor iajps</a></div><p class="ds-related-work--abstract ds2-5-body-sm">Patients with severe acute pancreatitis often require intensive care unit (ICU) admission, have multiple complications, spend weeks to months in the hospital, and consume a large amount of resources. The aim of this study is to analyse the outcome of patients with acute pancreatitis requiring intensive care admission. This descriptive study was conducted in Sargodha Medical College during June 2019 to January 2020. The Health information and management system was involved to retrieve medical record numbers of all adult patients (age 18-60 years) admitted in hospital with diagnosis of AP. Patients required ICU admission during the course of their disease were included, while patients having mild pancreatitis and managed else where were excluded from study. Mean age of patients was 49 years, out of which 55% were males and 45% females. Most of these patients were obese having mean BMI of 30.3 Kg/m2. Association of comorbid conditions showed predominance towards hypertension (44.7%) and diabetes mellitus (30.6%). Presence of gall stones (54%) was the main etiological factor which lead to AP. Other causes were alcohol consumption (13%) and idiopathic (15%). 56% of patients were admitted directly from ED, while rest of them were referred from special care unit (22%), general ward (6%) and operating room (15.3%). It is concluded that high morbidity and mortality of AP requiring ICU admission. We recommend the implementation of care bundles right from the start of hospital admission.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Marium Saleem et al, Analysis Of Different Outcomes Patients With Acute Pancreatitis Requiring Intensive Care Admission., Indo Am","attachmentId":64290110,"attachmentType":"pdf","work_url":"https://www.academia.edu/43962691/Marium_Saleem_et_al_Analysis_Of_Different_Outcomes_Patients_With_Acute_Pancreatitis_Requiring_Intensive_Care_Admission_Indo_Am","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/43962691/Marium_Saleem_et_al_Analysis_Of_Different_Outcomes_Patients_With_Acute_Pancreatitis_Requiring_Intensive_Care_Admission_Indo_Am"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="34324789" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/34324789/Apache_II_Score_for_Assessment_and_Monitoring_of_Acute_Pancreatitis">Apache-II Score for Assessment and Monitoring of Acute Pancreatitis</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="67114944" href="https://huddersfield.academia.edu/DavidLeaper">David Leaper</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Lancet, 1989</p><p class="ds-related-work--abstract ds2-5-body-sm">The value of the Acute Physiology and Chronic Health Enquiry (APACHE-II) score, the Simplified Acute Physiology score, and the Medical Research Council (MRC) sepsis score were compared with clinical assessment and Ranson and Imrie scores in the evaluation and monitoring of acute pancreatitis in 290 attacks. Attacks were graded mild (231) if uncomplicated, or severe (59) when major organ failure or a pancreatic collection occurred. Only APACHE-II scores were available at the time of admission; they correctly predicted outcome in 77% of attacks and identified 63% of severe attacks, compared with 44% achieved by clinical assessment. After 48 h, APACHE-II was most accurate, and correctly predicted outcome in 88% of attacks, compared with 69% for Ranson and 84% for Imrie scores. APACHE-II predicted 73% of pancreatic collections at 48 h, compared with 65% for Ranson and 58% for Imrie scores. In acute pancreatitis, APACHE-II may facilitate rapid selection of patients for intensive therapy or clinical trials, improve comparison between groups of patients, and indicate that a pancreatic collection is probable.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Apache-II Score for Assessment and Monitoring of Acute Pancreatitis","attachmentId":54222566,"attachmentType":"pdf","work_url":"https://www.academia.edu/34324789/Apache_II_Score_for_Assessment_and_Monitoring_of_Acute_Pancreatitis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/34324789/Apache_II_Score_for_Assessment_and_Monitoring_of_Acute_Pancreatitis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":73795412,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":73795412,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_73795412" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="13080989" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13080989/Correlates_of_organ_failure_in_severe_acute_pancreatitis">Correlates of organ failure in severe acute pancreatitis</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32326458" href="https://pgimer.academia.edu/RakeshKochhar">Rakesh Kochhar</a></div><p class="ds-related-work--metadata ds2-5-body-xs">JOP : Journal of the pancreas, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Correlates of organ failure in severe acute pancreatitis","attachmentId":45696014,"attachmentType":"pdf","work_url":"https://www.academia.edu/13080989/Correlates_of_organ_failure_in_severe_acute_pancreatitis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/13080989/Correlates_of_organ_failure_in_severe_acute_pancreatitis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="1" data-entity-id="22972027" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/22972027/Prognostic_factors_in_acute_pancreatitis">Prognostic factors in acute pancreatitis</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="44594641" href="https://independent.academia.edu/BlameyS">S. Blamey</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Gut, 1984</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Prognostic factors in acute pancreatitis","attachmentId":43493787,"attachmentType":"pdf","work_url":"https://www.academia.edu/22972027/Prognostic_factors_in_acute_pancreatitis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/22972027/Prognostic_factors_in_acute_pancreatitis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div 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