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<li id="toc-Characterization_methods" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Characterization_methods"> <div class="vector-toc-text"> 3 Characterization methods </div> </a> <button aria-controls="toc-Characterization_methods-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle Characterization methods subsection </button> <ul id="toc-Characterization_methods-sublist" class="vector-toc-list"> <li id="toc-Electrical_measurements" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Electrical_measurements"> <div class="vector-toc-text"> 3.1 Electrical measurements </div> </a> <ul id="toc-Electrical_measurements-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Fluorescence_microscopy" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Fluorescence_microscopy"> <div class="vector-toc-text"> 3.2 Fluorescence microscopy </div> </a> <ul id="toc-Fluorescence_microscopy-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Electron_microscopy" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Electron_microscopy"> <div class="vector-toc-text"> 3.3 Electron microscopy </div> </a> <ul id="toc-Electron_microscopy-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Nuclear_magnetic_resonance_spectroscopy" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Nuclear_magnetic_resonance_spectroscopy"> <div class="vector-toc-text"> 3.4 Nuclear magnetic resonance spectroscopy </div> </a> <ul id="toc-Nuclear_magnetic_resonance_spectroscopy-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Atomic_force_microscopy" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Atomic_force_microscopy"> <div class="vector-toc-text"> 3.5 Atomic force microscopy </div> </a> <ul id="toc-Atomic_force_microscopy-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Dual_polarisation_interferometry" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Dual_polarisation_interferometry"> <div class="vector-toc-text"> 3.6 Dual polarisation interferometry </div> </a> <ul id="toc-Dual_polarisation_interferometry-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Quantum_chemical_calculations" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Quantum_chemical_calculations"> <div class="vector-toc-text"> 3.7 Quantum chemical calculations </div> </a> <ul id="toc-Quantum_chemical_calculations-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Transport_across_the_bilayer" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Transport_across_the_bilayer"> <div class="vector-toc-text"> 4 Transport across the bilayer </div> </a> <button aria-controls="toc-Transport_across_the_bilayer-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle Transport across the bilayer subsection </button> <ul id="toc-Transport_across_the_bilayer-sublist" class="vector-toc-list"> <li id="toc-Passive_diffusion" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Passive_diffusion"> <div class="vector-toc-text"> 4.1 Passive diffusion </div> </a> <ul id="toc-Passive_diffusion-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Ion_pumps_and_channels" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Ion_pumps_and_channels"> <div class="vector-toc-text"> 4.2 Ion pumps and channels </div> </a> <ul id="toc-Ion_pumps_and_channels-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Endocytosis_and_exocytosis" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Endocytosis_and_exocytosis"> <div class="vector-toc-text"> 4.3 Endocytosis and exocytosis </div> </a> <ul id="toc-Endocytosis_and_exocytosis-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Electroporation" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Electroporation"> <div class="vector-toc-text"> 4.4 Electroporation </div> </a> <ul id="toc-Electroporation-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Mechanics" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Mechanics"> <div class="vector-toc-text"> 5 Mechanics </div> </a> <ul id="toc-Mechanics-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Fusion" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Fusion"> <div class="vector-toc-text"> 6 Fusion </div> </a> <ul id="toc-Fusion-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Model_systems" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Model_systems"> <div class="vector-toc-text"> 7 Model systems </div> </a> <ul id="toc-Model_systems-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Commercial_applications" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Commercial_applications"> <div class="vector-toc-text"> 8 Commercial applications </div> </a> <ul id="toc-Commercial_applications-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-History" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#History"> <div class="vector-toc-text"> 9 History </div> </a> <ul id="toc-History-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-See_also" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#See_also"> <div class="vector-toc-text"> 10 See also </div> </a> <ul id="toc-See_also-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> 11 References </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#External_links"> <div class="vector-toc-text"> 12 External links </div> </a> <ul id="toc-External_links-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" title="Table of Contents" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" > Toggle the table of contents </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading">Lipid bilayer</h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. Available in 41 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-41" aria-hidden="true" > 41 languages </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D9%84%D9%8A%D8%A8%D9%8A%D8%AF_%D8%AB%D9%86%D8%A7%D8%A6%D9%8A_%D8%A7%D9%84%D8%B7%D8%A8%D9%82%D8%A9" title="ليبيد ثنائي الطبقة – Arabic" lang="ar" hreflang="ar" data-title="ليبيد ثنائي الطبقة" data-language-autonym="العربية" data-language-local-name="Arabic" class="interlanguage-link-target">العربية</a></li><li class="interlanguage-link interwiki-zh-min-nan mw-list-item"><a href="https://zh-min-nan.wikipedia.org/wiki/L%C3%AEn-chi-chit_siang-ch%C3%A2n" title="Lîn-chi-chit siang-chân – Minnan" lang="nan" hreflang="nan" data-title="Lîn-chi-chit siang-chân" data-language-autonym="閩南語 / Bân-lâm-gú" data-language-local-name="Minnan" class="interlanguage-link-target">閩南語 / Bân-lâm-gú</a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/Lipidni_dvosloj" title="Lipidni dvosloj – Bosnian" lang="bs" hreflang="bs" data-title="Lipidni dvosloj" data-language-autonym="Bosanski" data-language-local-name="Bosnian" class="interlanguage-link-target">Bosanski</a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Bicapa_lip%C3%ADdica" title="Bicapa lipídica – Catalan" lang="ca" hreflang="ca" data-title="Bicapa lipídica" data-language-autonym="Català" data-language-local-name="Catalan" class="interlanguage-link-target">Català</a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Lipidov%C3%A1_dvouvrstva" title="Lipidová dvouvrstva – Czech" lang="cs" hreflang="cs" data-title="Lipidová dvouvrstva" data-language-autonym="Čeština" data-language-local-name="Czech" class="interlanguage-link-target">Čeština</a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Doppellipidschicht" title="Doppellipidschicht – German" lang="de" hreflang="de" data-title="Doppellipidschicht" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target">Deutsch</a></li><li class="interlanguage-link interwiki-et mw-list-item"><a href="https://et.wikipedia.org/wiki/Lipiidne_kaksikkiht" title="Lipiidne kaksikkiht – Estonian" lang="et" hreflang="et" data-title="Lipiidne kaksikkiht" data-language-autonym="Eesti" data-language-local-name="Estonian" class="interlanguage-link-target">Eesti</a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Bicapa_lip%C3%ADdica" title="Bicapa lipídica – Spanish" lang="es" hreflang="es" data-title="Bicapa lipídica" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target">Español</a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/Bigeruza_lipidiko" title="Bigeruza lipidiko – Basque" lang="eu" hreflang="eu" data-title="Bigeruza lipidiko" data-language-autonym="Euskara" data-language-local-name="Basque" class="interlanguage-link-target">Euskara</a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%BA%D8%B4%D8%A7%DB%8C_%D8%AF%D9%88%D9%84%D8%A7%DB%8C%D9%87_%D9%84%DB%8C%D9%BE%DB%8C%D8%AF%DB%8C" title="غشای دولایه لیپیدی – Persian" lang="fa" hreflang="fa" data-title="غشای دولایه لیپیدی" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target">فارسی</a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Bicouche_lipidique" title="Bicouche lipidique – French" lang="fr" hreflang="fr" data-title="Bicouche lipidique" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target">Français</a></li><li class="interlanguage-link interwiki-gv mw-list-item"><a href="https://gv.wikipedia.org/wiki/Daa-vrat_lipaidagh" title="Daa-vrat lipaidagh – Manx" lang="gv" hreflang="gv" data-title="Daa-vrat lipaidagh" data-language-autonym="Gaelg" data-language-local-name="Manx" class="interlanguage-link-target">Gaelg</a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Bicapa_lip%C3%ADdica" title="Bicapa lipídica – Galician" lang="gl" hreflang="gl" data-title="Bicapa lipídica" data-language-autonym="Galego" data-language-local-name="Galician" class="interlanguage-link-target">Galego</a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EC%A7%80%EC%A7%88_%EC%9D%B4%EC%A4%91%EC%B8%B5" title="지질 이중층 – Korean" lang="ko" hreflang="ko" data-title="지질 이중층" data-language-autonym="한국어" data-language-local-name="Korean" class="interlanguage-link-target">한국어</a></li><li class="interlanguage-link interwiki-hy mw-list-item"><a href="https://hy.wikipedia.org/wiki/%D4%BC%D5%AB%D5%BA%D5%AB%D5%A4%D5%A1%D5%B5%D5%AB%D5%B6_%D5%A5%D6%80%D5%AF%D5%B7%D5%A5%D6%80%D5%BF" title="Լիպիդային երկշերտ – Armenian" lang="hy" hreflang="hy" data-title="Լիպիդային երկշերտ" data-language-autonym="Հայերեն" data-language-local-name="Armenian" class="interlanguage-link-target">Հայերեն</a></li><li class="interlanguage-link interwiki-hi mw-list-item"><a href="https://hi.wikipedia.org/wiki/%E0%A4%B2%E0%A4%BF%E0%A4%AA%E0%A4%BF%E0%A4%A1_%E0%A4%A6%E0%A5%8D%E0%A4%B5%E0%A4%BF%E0%A4%AA%E0%A4%B0%E0%A4%A4" title="लिपिड द्विपरत – Hindi" lang="hi" hreflang="hi" data-title="लिपिड द्विपरत" data-language-autonym="हिन्दी" data-language-local-name="Hindi" class="interlanguage-link-target">हिन्दी</a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Dwilapis_lipid" title="Dwilapis lipid – Indonesian" lang="id" hreflang="id" data-title="Dwilapis lipid" data-language-autonym="Bahasa Indonesia" data-language-local-name="Indonesian" class="interlanguage-link-target">Bahasa Indonesia</a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Doppio_foglietto_fosfolipidico" title="Doppio foglietto fosfolipidico – Italian" lang="it" hreflang="it" data-title="Doppio foglietto fosfolipidico" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target">Italiano</a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%93%D7%95-%D7%A9%D7%9B%D7%91%D7%94_%D7%9C%D7%99%D7%A4%D7%99%D7%93%D7%99%D7%AA" title="דו-שכבה ליפידית – Hebrew" lang="he" hreflang="he" data-title="דו-שכבה ליפידית" data-language-autonym="עברית" data-language-local-name="Hebrew" class="interlanguage-link-target">עברית</a></li><li class="interlanguage-link interwiki-jv mw-list-item"><a href="https://jv.wikipedia.org/wiki/Lipida_dwilapis" title="Lipida dwilapis – Javanese" lang="jv" hreflang="jv" data-title="Lipida dwilapis" data-language-autonym="Jawa" data-language-local-name="Javanese" class="interlanguage-link-target">Jawa</a></li><li class="interlanguage-link interwiki-lv mw-list-item"><a href="https://lv.wikipedia.org/wiki/Lip%C4%ABdu_dubultsl%C4%81nis" title="Lipīdu dubultslānis – Latvian" lang="lv" hreflang="lv" data-title="Lipīdu dubultslānis" data-language-autonym="Latviešu" data-language-local-name="Latvian" class="interlanguage-link-target">Latviešu</a></li><li class="interlanguage-link interwiki-ml mw-list-item"><a href="https://ml.wikipedia.org/wiki/%E0%B4%95%E0%B5%8A%E0%B4%B4%E0%B5%81%E0%B4%AA%E0%B5%8D%E0%B4%AA%E0%B5%8D_%E0%B4%A6%E0%B5%8D%E0%B4%B5%E0%B4%AF%E0%B4%AA%E0%B4%BE%E0%B4%B3%E0%B4%BF" title="കൊഴുപ്പ് ദ്വയപാളി – Malayalam" lang="ml" hreflang="ml" data-title="കൊഴുപ്പ് ദ്വയപാളി" data-language-autonym="മലയാളം" data-language-local-name="Malayalam" class="interlanguage-link-target">മലയാളം</a></li><li class="interlanguage-link interwiki-ms mw-list-item"><a href="https://ms.wikipedia.org/wiki/Dwilapisan_lipid" title="Dwilapisan lipid – Malay" lang="ms" hreflang="ms" data-title="Dwilapisan lipid" data-language-autonym="Bahasa Melayu" data-language-local-name="Malay" class="interlanguage-link-target">Bahasa Melayu</a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Lipide_dubbellaag" title="Lipide dubbellaag – Dutch" lang="nl" hreflang="nl" data-title="Lipide dubbellaag" data-language-autonym="Nederlands" data-language-local-name="Dutch" class="interlanguage-link-target">Nederlands</a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E8%84%82%E8%B3%AA%E4%BA%8C%E9%87%8D%E5%B1%A4" title="脂質二重層 – Japanese" lang="ja" hreflang="ja" data-title="脂質二重層" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target">日本語</a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%AE%E0%AD%87%E0%AC%A6%E0%AC%A6%E0%AD%8D%E0%AD%B1%E0%AC%BF%E0%AC%B8%E0%AD%8D%E0%AC%A4%E0%AC%B0" title="ମେଦଦ୍ୱିସ୍ତର – Odia" lang="or" hreflang="or" data-title="ମେଦଦ୍ୱିସ୍ତର" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="Odia" class="interlanguage-link-target">ଓଡ଼ିଆ</a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Dwuwarstwa_lipidowa" title="Dwuwarstwa lipidowa – Polish" lang="pl" hreflang="pl" data-title="Dwuwarstwa lipidowa" data-language-autonym="Polski" data-language-local-name="Polish" class="interlanguage-link-target">Polski</a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Bicapa_lip%C3%ADdica" title="Bicapa lipídica – Portuguese" lang="pt" hreflang="pt" data-title="Bicapa lipídica" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target">Português</a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Bistrat_lipidic" title="Bistrat lipidic – Romanian" lang="ro" hreflang="ro" data-title="Bistrat lipidic" data-language-autonym="Română" data-language-local-name="Romanian" class="interlanguage-link-target">Română</a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%91%D0%B8%D1%81%D0%BB%D0%BE%D0%B9" title="Бислой – Russian" lang="ru" hreflang="ru" data-title="Бислой" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target">Русский</a></li><li class="interlanguage-link interwiki-simple mw-list-item"><a href="https://simple.wikipedia.org/wiki/Lipid_bilayer" title="Lipid bilayer – Simple English" lang="en-simple" hreflang="en-simple" data-title="Lipid bilayer" data-language-autonym="Simple English" data-language-local-name="Simple English" class="interlanguage-link-target">Simple English</a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Fosfolipidna_dvojna_plast" title="Fosfolipidna dvojna plast – Slovenian" lang="sl" hreflang="sl" data-title="Fosfolipidna dvojna plast" data-language-autonym="Slovenščina" data-language-local-name="Slovenian" class="interlanguage-link-target">Slovenščina</a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Lipidni_dvosloj" title="Lipidni dvosloj – Serbian" lang="sr" hreflang="sr" data-title="Lipidni dvosloj" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target">Српски / srpski</a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Lipidni_dvosloj" title="Lipidni dvosloj – Serbo-Croatian" lang="sh" hreflang="sh" data-title="Lipidni dvosloj" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Serbo-Croatian" class="interlanguage-link-target">Srpskohrvatski / српскохрватски</a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Lipidbilager" title="Lipidbilager – Swedish" lang="sv" hreflang="sv" data-title="Lipidbilager" data-language-autonym="Svenska" data-language-local-name="Swedish" class="interlanguage-link-target">Svenska</a></li><li class="interlanguage-link interwiki-ta mw-list-item"><a href="https://ta.wikipedia.org/wiki/%E0%AE%95%E0%AF%8A%E0%AE%B4%E0%AF%81%E0%AE%AE%E0%AE%BF%E0%AE%AF_%E0%AE%88%E0%AE%B0%E0%AE%9F%E0%AF%81%E0%AE%95%E0%AF%8D%E0%AE%95%E0%AF%81" title="கொழுமிய ஈரடுக்கு – Tamil" lang="ta" hreflang="ta" data-title="கொழுமிய 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</div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> <div id="mw-indicator-good-star" class="mw-indicator"><div class="mw-parser-output"><a href="/wiki/Wikipedia:Good_articles*" title="This is a good article. Click here for more information."><img alt="This is a good article. Click here for more information." src="//upload.wikimedia.org/wikipedia/en/thumb/9/94/Symbol_support_vote.svg/19px-Symbol_support_vote.svg.png" decoding="async" width="19" height="20" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/9/94/Symbol_support_vote.svg/29px-Symbol_support_vote.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/9/94/Symbol_support_vote.svg/39px-Symbol_support_vote.svg.png 2x" data-file-width="180" data-file-height="185" /></a></div></div> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Biological membrane structure</div> <figure class="mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/File:Lipid_bilayer_section.gif" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/f/f0/Lipid_bilayer_section.gif" decoding="async" width="300" height="195" class="mw-file-element" data-file-width="300" data-file-height="195" /></a><figcaption>This fluid <a href="/wiki/Lipid" title="Lipid">lipid</a> bilayer cross section is made up entirely of <a href="/wiki/Phosphatidylcholine" title="Phosphatidylcholine">phosphatidylcholine</a>.</figcaption></figure> <figure class="mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/File:Phospholipids_aqueous_solution_structures.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c6/Phospholipids_aqueous_solution_structures.svg/300px-Phospholipids_aqueous_solution_structures.svg.png" decoding="async" width="300" height="369" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c6/Phospholipids_aqueous_solution_structures.svg/450px-Phospholipids_aqueous_solution_structures.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c6/Phospholipids_aqueous_solution_structures.svg/600px-Phospholipids_aqueous_solution_structures.svg.png 2x" data-file-width="331" data-file-height="407" /></a><figcaption>The three main structures phospholipids form in solution; the <a href="/wiki/Liposome" title="Liposome">liposome</a> (a closed bilayer), the micelle and the bilayer.<a href="#cite_note-1">[1]</a></figcaption></figure> The lipid bilayer (or phospholipid bilayer) is a thin <a href="/wiki/Polar_membrane" class="mw-redirect" title="Polar membrane">polar membrane</a> made of two layers of <a href="/wiki/Lipid" title="Lipid">lipid</a> <a href="/wiki/Molecule" title="Molecule">molecules</a>. These membranes form a continuous barrier around all <a href="/wiki/Cell_(biology)" title="Cell (biology)">cells</a>. The <a href="/wiki/Cell_membrane" title="Cell membrane">cell membranes</a> of almost all <a href="/wiki/Organisms" class="mw-redirect" title="Organisms">organisms</a> and many <a href="/wiki/Virus" title="Virus">viruses</a> are made of a lipid bilayer, as are the <a href="/wiki/Nuclear_envelope" title="Nuclear envelope">nuclear membrane</a> surrounding the <a href="/wiki/Cell_nucleus" title="Cell nucleus">cell nucleus</a>, and <a href="/wiki/Biological_membrane" title="Biological membrane">membranes</a> of the <a href="/wiki/Membrane-bound_organelle" class="mw-redirect" title="Membrane-bound organelle">membrane-bound organelles</a> in the cell. The lipid bilayer is the barrier that keeps <a href="/wiki/Ion" title="Ion">ions</a>, <a href="/wiki/Protein" title="Protein">proteins</a> and other molecules where they are needed and prevents them from diffusing into areas where they should not be. Lipid bilayers are ideally suited to this role, even though they are only a few <a href="/wiki/Nanometer" class="mw-redirect" title="Nanometer">nanometers</a> in width,<a href="#cite_note-andersen2007-2">[2]</a> because they are impermeable to most water-soluble (<a href="/wiki/Hydrophilic" class="mw-redirect" title="Hydrophilic">hydrophilic</a>) molecules. Bilayers are particularly impermeable to ions, which allows cells to regulate salt concentrations and <a href="/wiki/PH" title="PH">pH</a> by transporting ions across their membranes using proteins called <a href="/wiki/Ion_transporter" title="Ion transporter">ion pumps</a>. Biological bilayers are usually composed of <a href="/wiki/Amphiphile" title="Amphiphile">amphiphilic</a> <a href="/wiki/Phospholipid" title="Phospholipid">phospholipids</a> that have a hydrophilic phosphate head and a <a href="/wiki/Hydrophobic" class="mw-redirect" title="Hydrophobic">hydrophobic</a> tail consisting of two fatty acid chains. Phospholipids with certain head groups can alter the surface chemistry of a bilayer and can, for example, serve as signals as well as "anchors" for other molecules in the membranes of cells.<a href="#cite_note-Divecha1995-3">[3]</a> Just like the heads, the tails of lipids can also affect membrane properties, for instance by determining the <a href="/wiki/Phase_(matter)" title="Phase (matter)">phase</a> of the bilayer. The bilayer can adopt a solid <a href="/wiki/Gel" title="Gel">gel</a> phase state at lower temperatures but undergo <a href="/wiki/Phase_transition" title="Phase transition">phase transition</a> to a <a href="/wiki/Fluids" class="mw-redirect" title="Fluids">fluid state</a> at higher temperatures, and the chemical properties of the lipids' tails influence at which temperature this happens. The packing of lipids within the bilayer also affects its mechanical properties, including its resistance to stretching and bending. Many of these properties have been studied with the use of artificial "model" bilayers produced in a lab. <a href="/wiki/Vesicle_(biology_and_chemistry)" title="Vesicle (biology and chemistry)">Vesicles</a> made by model bilayers have also been used clinically to deliver drugs. The structure of <a href="/wiki/Biological_membrane" title="Biological membrane">biological membranes</a> typically includes several types of molecules in addition to the phospholipids comprising the bilayer. A particularly important example in animal cells is <a href="/wiki/Cholesterol" title="Cholesterol">cholesterol</a>, which helps strengthen the bilayer and decrease its permeability. Cholesterol also helps regulate the activity of certain <a href="/wiki/Integral_membrane_protein" title="Integral membrane protein">integral membrane proteins</a>. Integral membrane proteins function when incorporated into a lipid bilayer, and they are held tightly to the lipid bilayer with the help of an <a href="/wiki/Annular_lipid_shell" title="Annular lipid shell">annular lipid shell</a>. Because bilayers define the boundaries of the cell and its compartments, these membrane proteins are involved in many intra- and inter-cellular signaling processes. Certain kinds of membrane proteins are involved in the process of fusing two bilayers together. This fusion allows the joining of two distinct structures as in the <a href="/wiki/Acrosome_reaction" title="Acrosome reaction">acrosome reaction</a> during <a href="/wiki/Fertilization" class="mw-redirect" title="Fertilization">fertilization</a> of an <a href="/wiki/Egg_(biology)" class="mw-redirect" title="Egg (biology)">egg</a> by a <a href="/wiki/Sperm" title="Sperm">sperm</a>, or the entry of a <a href="/wiki/Virus" title="Virus">virus</a> into a cell. Because lipid bilayers are fragile and invisible in a traditional microscope, they are a challenge to study. Experiments on bilayers often require advanced techniques like <a href="/wiki/Electron_microscopy" class="mw-redirect" title="Electron microscopy">electron microscopy</a> and <a href="/wiki/Atomic_force_microscopy" title="Atomic force microscopy">atomic force microscopy</a>. <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Structure_and_organization">Structure and organization</h2>[<a href="/w/index.php?title=Lipid_bilayer&action=edit&section=1" title="Edit section: Structure and organization">edit</a>]</div> When phospholipids are exposed to water, they <a href="/wiki/Molecular_self-assembly" title="Molecular self-assembly">self-assemble</a> into a two-layered sheet with the hydrophobic tails pointing toward the center of the sheet. This arrangement results in two 'leaflets' that are each a single molecular layer. The center of this bilayer contains almost no water and excludes molecules like <a href="/wiki/Sugar" title="Sugar">sugars</a> or salts that dissolve in water. The assembly process and maintenance are driven by aggregation of hydrophobic molecules (also called the <a href="/wiki/Hydrophobic_effect" title="Hydrophobic effect">hydrophobic effect</a>). This complex process includes <a href="/wiki/Non-covalent_interactions" class="mw-redirect" title="Non-covalent interactions">non-covalent interactions</a> such as <a href="/wiki/Van_der_Waals_force" title="Van der Waals force">van der Waals forces</a>, <a href="/wiki/Electrostatic" class="mw-redirect" title="Electrostatic">electrostatic</a> and <a href="/wiki/Hydrogen_bonds" class="mw-redirect" title="Hydrogen bonds">hydrogen bonds</a>.<a href="#cite_note-Chen_2010-4">[4]</a> <div class="mw-heading mw-heading3"><h3 id="Cross-section_analysis">Cross-section analysis</h3>[<a href="/w/index.php?title=Lipid_bilayer&action=edit&section=2" title="Edit section: Cross-section analysis">edit</a>]</div> <figure class="mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/File:Bilayer_hydration_profile.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/e/ed/Bilayer_hydration_profile.svg/310px-Bilayer_hydration_profile.svg.png" decoding="async" width="310" height="303" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/ed/Bilayer_hydration_profile.svg/465px-Bilayer_hydration_profile.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/ed/Bilayer_hydration_profile.svg/620px-Bilayer_hydration_profile.svg.png 2x" data-file-width="691" data-file-height="676" /></a><figcaption>Schematic cross sectional profile of a typical lipid bilayer. There are three distinct regions: the fully hydrated headgroups, the fully dehydrated alkane core and a short intermediate region with partial hydration. Although the head groups are neutral, they have significant dipole moments that influence the molecular arrangement.<a href="#cite_note-5">[5]</a></figcaption></figure> The lipid bilayer is very thin compared to its lateral dimensions. If a typical mammalian cell (diameter ~10 micrometers) were magnified to the size of a watermelon (~1 ft/30 cm), the lipid bilayer making up the <a href="/wiki/Plasma_membrane" class="mw-redirect" title="Plasma membrane">plasma membrane</a> would be about as thick as a piece of office paper. Despite being only a few nanometers thick, the bilayer is composed of several distinct chemical regions across its cross-section. These regions and their interactions with the surrounding water have been characterized over the past several decades with <a href="/wiki/X-ray_reflectometry" class="mw-redirect" title="X-ray reflectometry">x-ray reflectometry</a>,<a href="#cite_note-Lewis1983-6">[6]</a> <a href="/wiki/Neutron_scattering" title="Neutron scattering">neutron scattering</a>,<a href="#cite_note-Zaccai1975-7">[7]</a> and <a href="/wiki/Nuclear_magnetic_resonance" title="Nuclear magnetic resonance">nuclear magnetic resonance</a> techniques.<a href="#cite_note-Skarjune_1982-8">[8]</a> The first region on either side of the bilayer is the hydrophilic headgroup. This portion of the membrane is completely hydrated and is typically around 0.8-0.9 nm thick. In <a href="/wiki/Phospholipid" title="Phospholipid">phospholipid</a> bilayers the <a href="/wiki/Phosphate" title="Phosphate">phosphate</a> group is located within this hydrated region, approximately 0.5 nm outside the hydrophobic core.<a href="#cite_note-Nagle2000-9">[9]</a> In some cases, the hydrated region can extend much further, for instance in lipids with a large protein or long sugar chain grafted to the head. One common example of such a modification in nature is the <a href="/wiki/Lipopolysaccharide" title="Lipopolysaccharide">lipopolysaccharide</a> coat on a bacterial outer membrane.<a href="#cite_note-Avila-Calderón_2021-10">[10]</a> <figure typeof="mw:File/Thumb"><a href="/wiki/File:Bacillus_subtilis.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/91/Bacillus_subtilis.jpg/240px-Bacillus_subtilis.jpg" decoding="async" width="240" height="180" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/91/Bacillus_subtilis.jpg/360px-Bacillus_subtilis.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/91/Bacillus_subtilis.jpg/480px-Bacillus_subtilis.jpg 2x" data-file-width="1376" data-file-height="1032" /></a><figcaption><a href="/wiki/Transmission_electron_microscopy" title="Transmission electron microscopy">TEM</a> image of a bacterium. The furry appearance on the outside is due to a coat of long-chain sugars attached to the cell membrane. This coating helps trap water to prevent the bacterium from becoming dehydrated.</figcaption></figure> Next to the hydrated region is an intermediate region that is only partially hydrated. This boundary layer is approximately 0.3 nm thick. Within this short distance, the water concentration drops from 2M on the headgroup side to nearly zero on the tail (core) side.<a href="#cite_note-Marsh2001-11">[11]</a><a href="#cite_note-Marsh2002-12">[12]</a> The hydrophobic core of the bilayer is typically 3-4 nm thick, but this value varies with chain length and chemistry.<a href="#cite_note-Lewis1983-6">[6]</a><a href="#cite_note-Rawicz2000-13">[13]</a> Core thickness also varies significantly with temperature, in particular near a phase transition.<a href="#cite_note-Trauble1971-14">[14]</a> <div class="mw-heading mw-heading3"><h3 id="Asymmetry">Asymmetry</h3>[<a href="/w/index.php?title=Lipid_bilayer&action=edit&section=3" title="Edit section: Asymmetry">edit</a>]</div> In many naturally occurring bilayers, the compositions of the inner and outer membrane leaflets are different. In human <a href="/wiki/Erythrocyte" class="mw-redirect" title="Erythrocyte">red blood cells</a>, the inner (cytoplasmic) leaflet is composed mostly of <a href="/wiki/Phosphatidylethanolamine" title="Phosphatidylethanolamine">phosphatidylethanolamine</a>, <a href="/wiki/Phosphatidylserine" title="Phosphatidylserine">phosphatidylserine</a> and <a href="/wiki/Phosphatidylinositol" title="Phosphatidylinositol">phosphatidylinositol</a> and its phosphorylated derivatives. By contrast, the outer (extracellular) leaflet is based on <a href="/wiki/Phosphatidylcholine" title="Phosphatidylcholine">phosphatidylcholine</a>, <a href="/wiki/Sphingomyelin" title="Sphingomyelin">sphingomyelin</a> and a variety of glycolipids.<a href="#cite_note-Bretscher1972-15">[15]</a><a href="#cite_note-Verkleij1973-16">[16]</a><a href="#cite_note-17">[17]</a> In some cases, this asymmetry is based on where the lipids are made in the cell and reflects their initial orientation.<a href="#cite_note-Bell1981-18">[18]</a> The biological functions of lipid asymmetry are imperfectly understood, although it is clear that it is used in several different situations. For example, when a cell undergoes <a href="/wiki/Apoptosis" title="Apoptosis">apoptosis</a>, the phosphatidylserine — normally localised to the cytoplasmic leaflet — is transferred to the outer surface: There, it is recognised by a <a href="/wiki/Macrophage" title="Macrophage">macrophage</a> that then actively scavenges the dying cell.<a href="#cite_note-Fadoka1998-19">[19]</a> Lipid asymmetry arises, at least in part, from the fact that most phospholipids are synthesised and initially inserted into the inner monolayer: those that constitute the outer monolayer are then transported from the inner monolayer by a class of enzymes called <a href="/wiki/Flippase" title="Flippase">flippases</a>.<a href="#cite_note-Bretscher1973-20">[20]</a><a href="#cite_note-Rothman1977-21">[21]</a> Other lipids, such as sphingomyelin, appear to be synthesised at the external leaflet. Flippases are members of a larger family of lipid transport molecules that also includes floppases, which transfer lipids in the opposite direction, and scramblases, which randomize lipid distribution across lipid bilayers (as in apoptotic cells). In any case, once lipid asymmetry is established, it does not normally dissipate quickly because spontaneous flip-flop of lipids between leaflets is extremely slow.<a href="#cite_note-Kornberg1971-22">[22]</a> It is possible to mimic this asymmetry in the laboratory in model bilayer systems. Certain types of very small artificial <a href="/wiki/Vesicle_(biology)" class="mw-redirect" title="Vesicle (biology)">vesicle</a> will automatically make themselves slightly asymmetric, although the mechanism by which this asymmetry is generated is very different from that in cells.<a href="#cite_note-Litman1974-23">[23]</a> By utilizing two different monolayers in <a href="/wiki/Langmuir-Blodgett_film" class="mw-redirect" title="Langmuir-Blodgett film">Langmuir-Blodgett</a> deposition<a href="#cite_note-Crane2005-24">[24]</a> or a combination of Langmuir-Blodgett and vesicle rupture deposition<a href="#cite_note-Kalb1992-25">[25]</a> it is also possible to synthesize an asymmetric planar bilayer. This asymmetry may be lost over time as lipids in supported bilayers can be prone to flip-flop.<a href="#cite_note-Lin2006-26">[26]</a> However, it has been reported that lipid flip-flop is slow compare to cholesterol and other smaller molecules.<a href="#cite_note-27">[27]</a><a href="#cite_note-28">[28]</a> It has been reported that the organization and dynamics of the lipid monolayers in a bilayer are coupled.<a href="#cite_note-:0-29">[29]</a><a href="#cite_note-:1-30">[30]</a> For example, introduction of obstructions in one monolayer can slow down the lateral diffusion in both monolayers.<a href="#cite_note-:0-29">[29]</a> In addition, phase separation in one monolayer can also induce phase separation in other monolayer even when other monolayer can not phase separate by itself.<a href="#cite_note-:1-30">[30]</a> <div class="mw-heading mw-heading3"><h3 id="Phases_and_phase_transitions">Phases and phase transitions</h3>[<a href="/w/index.php?title=Lipid_bilayer&action=edit&section=4" title="Edit section: Phases and phase transitions">edit</a>]</div> <style data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">Further information: <a href="/wiki/Lipid_bilayer_phase_behavior" title="Lipid bilayer phase behavior">Lipid bilayer phase behavior</a></div> <figure class="mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/File:Lipid_unsaturation_effect.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2e/Lipid_unsaturation_effect.svg/350px-Lipid_unsaturation_effect.svg.png" decoding="async" width="350" height="236" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2e/Lipid_unsaturation_effect.svg/525px-Lipid_unsaturation_effect.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2e/Lipid_unsaturation_effect.svg/700px-Lipid_unsaturation_effect.svg.png 2x" data-file-width="444" data-file-height="299" /></a><figcaption>Diagram showing the effect of unsaturated lipids on a bilayer. The lipids with an unsaturated tail (blue) disrupt the packing of those with only saturated tails (black). The resulting bilayer has more free space and is, as a consequence, more permeable to water and other small molecules.</figcaption></figure> At a given temperature a lipid bilayer can exist in either a liquid or a gel (solid) phase. All lipids have a characteristic temperature at which they transition (melt) from the gel to liquid phase. In both phases the lipid molecules are prevented from flip-flopping across the bilayer, but in liquid phase bilayers a given lipid will exchange locations with its neighbor millions of times a second. This <a href="/wiki/Random_walk" title="Random walk">random walk</a> exchange allows lipid to <a href="/wiki/Diffusion" title="Diffusion">diffuse</a> and thus wander across the surface of the membrane.Unlike liquid phase bilayers, the lipids in a gel phase bilayer have less mobility.<a href="#cite_note-Berg1993-31">[31]</a> The phase behavior of lipid bilayers is determined largely by the strength of the attractive <a href="/wiki/Van_der_Waals_force" title="Van der Waals force">Van der Waals</a> interactions between adjacent lipid molecules. Longer-tailed lipids have more area over which to interact, increasing the strength of this interaction and, as a consequence, decreasing the lipid mobility. Thus, at a given temperature, a short-tailed lipid will be more fluid than an otherwise identical long-tailed lipid.<a href="#cite_note-Rawicz2000-13">[13]</a> Transition temperature can also be affected by the <a href="/wiki/Degree_of_unsaturation" title="Degree of unsaturation">degree of unsaturation</a> of the lipid tails. An unsaturated <a href="/wiki/Double_bond" title="Double bond">double bond</a> can produce a kink in the <a href="/wiki/Alkane" title="Alkane">alkane</a> chain, disrupting the lipid packing. This disruption creates extra free space within the bilayer that allows additional flexibility in the adjacent chains.<a href="#cite_note-Rawicz2000-13">[13]</a> An example of this effect can be noted in everyday life as butter, which has a large percentage saturated fats, is solid at room temperature while vegetable oil, which is mostly unsaturated, is liquid.<a href="#cite_note-32">[32]</a> Most natural membranes are a complex mixture of different lipid molecules. If some of the components are liquid at a given temperature while others are in the gel phase, the two phases can coexist in spatially separated regions, rather like an iceberg floating in the ocean. This phase separation plays a critical role in biochemical phenomena because membrane components such as proteins can partition into one or the other phase and thus be locally concentrated or activated.<a href="#cite_note-Dietrich2001-33">[33]</a> One particularly important component of many mixed phase systems is <a href="/wiki/Cholesterol" title="Cholesterol">cholesterol</a>, which modulates bilayer permeability, mechanical strength, and biochemical interactions.<a href="#cite_note-isbn1-4292-4646-4-34">[34]</a> <div class="mw-heading mw-heading3"><h3 id="Surface_chemistry">Surface chemistry</h3>[<a href="/w/index.php?title=Lipid_bilayer&action=edit&section=5" title="Edit section: Surface chemistry">edit</a>]</div> While lipid tails primarily modulate bilayer phase behavior, it is the headgroup that determines the bilayer surface chemistry. Most natural bilayers are composed primarily of <a href="/wiki/Phospholipid" title="Phospholipid">phospholipids</a>, but <a href="/wiki/Sphingolipids" class="mw-redirect" title="Sphingolipids">sphingolipids</a> and <a href="/wiki/Sterol" title="Sterol">sterols</a> such as <a href="/wiki/Cholesterol" title="Cholesterol">cholesterol</a> are also important components.<a href="#cite_note-35">[35]</a> Of the phospholipids, the most common headgroup is <a href="/wiki/Phosphatidylcholine" title="Phosphatidylcholine">phosphatidylcholine</a> (PC), accounting for about half the phospholipids in most mammalian cells.<a href="#cite_note-Yeagle1993-36">[36]</a> PC is a <a href="/wiki/Zwitterion" title="Zwitterion">zwitterionic</a> headgroup, as it has a negative charge on the phosphate group and a positive charge on the amine but, because these local charges balance, no net charge.<a href="#cite_note-Ko_2015-37">[37]</a> Other headgroups are also present to varying degrees and can include <a href="/wiki/Phosphatidylserine" title="Phosphatidylserine">phosphatidylserine</a> (PS) <a href="/wiki/Phosphatidylethanolamine" title="Phosphatidylethanolamine">phosphatidylethanolamine</a> (PE) and <a href="/wiki/Phosphatidylglycerol" title="Phosphatidylglycerol">phosphatidylglycerol</a> (PG). These alternate headgroups often confer specific biological functionality that is highly context-dependent. For instance, PS presence on the extracellular membrane face of <a href="/wiki/Erythrocyte" class="mw-redirect" title="Erythrocyte">erythrocytes</a> is a marker of cell <a href="/wiki/Apoptosis" title="Apoptosis">apoptosis</a>,<a href="#cite_note-Fadoka1998-19">[19]</a> whereas PS in <a href="/wiki/Growth_plate" class="mw-redirect" title="Growth plate">growth plate</a> vesicles is necessary for the <a href="/wiki/Nucleation" title="Nucleation">nucleation</a> of <a href="/wiki/Hydroxyapatite" title="Hydroxyapatite">hydroxyapatite</a> crystals and subsequent bone mineralization.<a href="#cite_note-Anderson2005-38">[38]</a><a href="#cite_note-Eanes1987-39">[39]</a> Unlike PC, some of the other headgroups carry a net charge, which can alter the electrostatic interactions of small molecules with the bilayer.<a href="#cite_note-Kim1991-40">[40]</a> <div class="mw-heading mw-heading2"><h2 id="Biological_roles">Biological roles</h2>[<a href="/w/index.php?title=Lipid_bilayer&action=edit&section=6" title="Edit section: Biological roles">edit</a>]</div> <div class="mw-heading mw-heading3"><h3 id="Containment_and_separation">Containment and separation</h3>[<a href="/w/index.php?title=Lipid_bilayer&action=edit&section=7" title="Edit section: Containment and separation">edit</a>]</div> The primary role of the lipid bilayer in biology is to separate <a href="/wiki/Aqueous_solution" title="Aqueous solution">aqueous</a> compartments from their surroundings. Without some form of barrier delineating “self” from “non-self”, it is difficult to even define the concept of an organism or of life. This barrier takes the form of a lipid bilayer in all known life forms except for a few species of <a href="/wiki/Archaea" title="Archaea">archaea</a> that utilize a specially adapted lipid monolayer.<a href="#cite_note-Brock2003-41">[41]</a> It has even been proposed that the very first form of life may have been a simple <a href="/wiki/Lipid_vesicle" class="mw-redirect" title="Lipid vesicle">lipid vesicle</a> with virtually its sole <a href="/wiki/Biosynthesis" title="Biosynthesis">biosynthetic</a> capability being the production of more <a href="/wiki/Phospholipid" title="Phospholipid">phospholipids</a>.<a href="#cite_note-Koch1985-42">[42]</a> The partitioning ability of the lipid bilayer is based on the fact that <a href="/wiki/Hydrophilic" class="mw-redirect" title="Hydrophilic">hydrophilic</a> molecules cannot easily cross the <a href="/wiki/Hydrophobic" class="mw-redirect" title="Hydrophobic">hydrophobic</a> bilayer core, as discussed in Transport across the bilayer below. The nucleus, mitochondria and chloroplasts have two lipid bilayers, while other sub-cellular structures are surrounded by a single lipid bilayer (such as the plasma membrane, endoplasmic reticula, Golgi apparatus and lysosomes). See <a href="/wiki/Organelle" title="Organelle">Organelle</a>.<a href="#cite_note-43">[43]</a> <a href="/wiki/Prokaryote" title="Prokaryote">Prokaryotes</a> have only one lipid bilayer - the <a href="/wiki/Cell_membrane" title="Cell membrane">cell membrane</a> (also known as the plasma membrane). Many prokaryotes also have a <a href="/wiki/Cell_wall" title="Cell wall">cell wall</a>, but the cell wall is composed of <a href="/wiki/Protein" title="Protein">proteins</a> or long chain <a href="/wiki/Carbohydrate" title="Carbohydrate">carbohydrates</a>, not lipids. In contrast, <a href="/wiki/Eukaryote" title="Eukaryote">eukaryotes</a> have a range of <a href="/wiki/Organelle" title="Organelle">organelles</a> including the <a href="/wiki/Cell_nucleus" title="Cell nucleus">nucleus</a>, <a href="/wiki/Mitochondria" class="mw-redirect" title="Mitochondria">mitochondria</a>, <a href="/wiki/Lysosome" title="Lysosome">lysosomes</a> and <a href="/wiki/Endoplasmic_reticulum" title="Endoplasmic reticulum">endoplasmic reticulum</a>. All of these sub-cellular compartments are surrounded by one or more lipid bilayers and, together, typically comprise the majority of the bilayer area present in the cell. In liver <a href="/wiki/Hepatocyte" title="Hepatocyte">hepatocytes</a> for example, the plasma membrane accounts for only two percent of the total bilayer area of the cell, whereas the endoplasmic reticulum contains more than fifty percent and the mitochondria a further thirty percent.<a href="#cite_note-Alberts2002-44">[44]</a> <figure typeof="mw:File/Thumb"><a href="/wiki/File:PDB_1hzx_7TM_Sketch_Membrane.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/f/f5/PDB_1hzx_7TM_Sketch_Membrane.png/260px-PDB_1hzx_7TM_Sketch_Membrane.png" decoding="async" width="260" height="182" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/f5/PDB_1hzx_7TM_Sketch_Membrane.png/390px-PDB_1hzx_7TM_Sketch_Membrane.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/f5/PDB_1hzx_7TM_Sketch_Membrane.png/520px-PDB_1hzx_7TM_Sketch_Membrane.png 2x" data-file-width="1029" data-file-height="720" /></a><figcaption>Illustration of a GPCR signaling protein. In response to a molecule such as a <a href="/wiki/Hormone" title="Hormone">hormone</a> binding to the exterior domain (blue) the GPCR changes shape and <a href="/wiki/Catalyzes" class="mw-redirect" title="Catalyzes">catalyzes</a> a chemical reaction on the interior domain (red). The gray feature is the surrounding bilayer.</figcaption></figure> <div class="mw-heading mw-heading3"><h3 id="Signaling">Signaling</h3>[<a href="/w/index.php?title=Lipid_bilayer&action=edit&section=8" title="Edit section: Signaling">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">See also: <a href="/wiki/Neurotransmission" title="Neurotransmission">Neurotransmission</a></div> The most familiar form of cellular signaling is likely <a href="/wiki/Synaptic_transmission" class="mw-redirect" title="Synaptic transmission">synaptic transmission</a>, whereby a nerve impulse that has reached the end of one <a href="/wiki/Neuron" title="Neuron">neuron</a> is conveyed to an adjacent neuron via the release of <a href="/wiki/Neurotransmitter" title="Neurotransmitter">neurotransmitters</a>. This transmission is made possible by the action of <a href="/wiki/Synaptic_vesicle" title="Synaptic vesicle">synaptic vesicles</a> which are, inside the cell, loaded with the neurotransmitters to be released later. These loaded vesicles <a href="/wiki/Lipid_bilayer_fusion" title="Lipid bilayer fusion">fuse</a> with the cell membrane at the pre-synaptic terminal and their contents are released into the space outside the cell. The contents then diffuse across the synapse to the post-synaptic terminal.<a href="#cite_note-45">[45]</a> Lipid bilayers are also involved in signal transduction through their role as the home of <a href="/wiki/Integral_membrane_protein" title="Integral membrane protein">integral membrane proteins</a>. This is an extremely broad and important class of biomolecule. It is estimated that up to a third of the human <a href="/wiki/Proteome" title="Proteome">proteome</a> are membrane proteins.<a href="#cite_note-Martelli2003-46">[46]</a> Some of these proteins are linked to the exterior of the cell membrane. An example of this is the <a href="/wiki/CD59" title="CD59">CD59</a> protein, which identifies cells as “self” and thus inhibits their destruction by the immune system. The <a href="/wiki/HIV" title="HIV">HIV</a> virus evades the <a href="/wiki/Immune_system" title="Immune system">immune system</a> in part by grafting these proteins from the host membrane onto its own surface.<a href="#cite_note-Alberts2002-44">[44]</a> Alternatively, some membrane proteins penetrate all the way through the bilayer and serve to relay individual signal events from the outside to the inside of the cell. The most common class of this type of protein is the <a href="/wiki/G_protein-coupled_receptor" title="G protein-coupled receptor">G protein-coupled receptor</a> (GPCR). GPCRs are responsible for much of the cell's ability to sense its surroundings and, because of this important role, approximately 40% of all modern drugs are targeted at GPCRs.<a href="#cite_note-Filmore2004-47">[47]</a> In addition to protein- and solution-mediated processes, it is also possible for lipid bilayers to participate directly in signaling. A classic example of this is <a href="/wiki/Phosphatidylserine" title="Phosphatidylserine">phosphatidylserine</a>-triggered <a href="/wiki/Phagocytosis" title="Phagocytosis">phagocytosis</a>. Normally, phosphatidylserine is asymmetrically distributed in the cell membrane and is present only on the interior side. During programmed cell death a protein called a <a href="/wiki/Scramblase" class="mw-redirect" title="Scramblase">scramblase</a> equilibrates this distribution, displaying phosphatidylserine on the extracellular bilayer face. The presence of phosphatidylserine then triggers phagocytosis to remove the dead or dying cell.<a href="#cite_note-48">[48]</a> <div class="mw-heading mw-heading2"><h2 id="Characterization_methods">Characterization methods</h2>[<a href="/w/index.php?title=Lipid_bilayer&action=edit&section=9" title="Edit section: Characterization methods">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Further information: <a href="/wiki/Lipid_bilayer_characterization" title="Lipid bilayer characterization">Lipid bilayer characterization</a></div> <figure class="mw-halign-left" typeof="mw:File/Thumb"><a href="/wiki/File:Annular_Gap_Junction_Vesicle.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/7/7b/Annular_Gap_Junction_Vesicle.jpg" decoding="async" width="205" height="153" class="mw-file-element" data-file-width="205" data-file-height="153" /></a><figcaption><a href="/wiki/Transmission_electron_microscopy" title="Transmission electron microscopy">Transmission Electron Microscope</a> (TEM) image of a <a href="/wiki/Lipid_vesicle" class="mw-redirect" title="Lipid vesicle">lipid vesicle</a>. The two dark bands around the edge are the two leaflets of the bilayer. Historically, similar images confirmed that the cell membrane is a bilayer</figcaption></figure> The lipid bilayer is a difficult structure to study because it is so thin and fragile.<a href="#cite_note-Crane_Tamm_2007-49">[49]</a> To overcome these limitations, techniques have been developed to allow investigations of its structure and function.<a href="#cite_note-Montal1972-50">[50]</a><a href="#cite_note-Crane_Tamm_2007-49">[49]</a><a href="#cite_note-Dubinnyi-51">[51]</a> <div class="mw-heading mw-heading3"><h3 id="Electrical_measurements">Electrical measurements</h3>[<a href="/w/index.php?title=Lipid_bilayer&action=edit&section=10" title="Edit section: Electrical measurements">edit</a>]</div> Electrical measurements are a straightforward way to characterize an important function of a bilayer: its ability to segregate and prevent the flow of ions in solution. By applying a voltage across the bilayer and measuring the resulting current, the <a href="/wiki/Electrical_resistance" class="mw-redirect" title="Electrical resistance">resistance</a> of the bilayer is determined. This resistance is typically quite high (108 Ohm-cm2 or more) <a href="#cite_note-Montal1972-50">[50]</a> since the hydrophobic core is impermeable to charged species. The presence of even a few nanometer-scale holes results in a dramatic increase in current.<a href="#cite_note-Melikov2001-52">[52]</a> The sensitivity of this system is such that even the activity of single <a href="/wiki/Ion_channel" title="Ion channel">ion channels</a> can be resolved.<a href="#cite_note-Neher1976-53">[53]</a> <div class="mw-heading mw-heading3"><h3 id="Fluorescence_microscopy">Fluorescence microscopy</h3>[<a href="/w/index.php?title=Lipid_bilayer&action=edit&section=11" title="Edit section: Fluorescence microscopy">edit</a>]</div> <figure class="mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/File:Sedimented_red_blood_cells.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c9/Sedimented_red_blood_cells.jpg/210px-Sedimented_red_blood_cells.jpg" decoding="async" width="210" height="220" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c9/Sedimented_red_blood_cells.jpg/315px-Sedimented_red_blood_cells.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/c/c9/Sedimented_red_blood_cells.jpg 2x" data-file-width="386" data-file-height="404" /></a><figcaption>Human red blood cells viewed through a fluorescence microscope. The <a href="/wiki/Cell_membrane" title="Cell membrane">cell membrane</a> has been stained with a fluorescent dye. Scale bar is 20μm.</figcaption></figure> A lipid bilayer cannot be seen with a traditional microscope because it is too thin, so researchers often use <a href="/wiki/Fluorescence_microscopy" class="mw-redirect" title="Fluorescence microscopy">fluorescence microscopy</a>. A sample is excited with one wavelength of light and observed in another, so that only fluorescent molecules with a matching excitation and emission profile will be seen. A natural lipid bilayer is not fluorescent, so at least one fluorescent dye needs to be attached to some of the molecules in the bilayer. Resolution is usually limited to a few hundred nanometers, which is unfortunately much larger than the thickness of a lipid bilayer.<a href="#cite_note-Crane_Tamm_2007-49">[49]</a> <div class="mw-heading mw-heading3"><h3 id="Electron_microscopy">Electron microscopy</h3>[<a href="/w/index.php?title=Lipid_bilayer&action=edit&section=12" title="Edit section: Electron microscopy">edit</a>]</div> <a href="/wiki/Electron_microscopy" class="mw-redirect" title="Electron microscopy">Electron microscopy</a> offers a higher resolution image. In an <a href="/wiki/Electron_microscope" title="Electron microscope">electron microscope</a>, a beam of focused <a href="/wiki/Electron" title="Electron">electrons</a> interacts with the sample rather than a beam of light as in traditional microscopy. In conjunction with rapid freezing techniques, electron microscopy has also been used to study the mechanisms of inter- and intracellular transport, for instance in demonstrating that <a href="/wiki/Exocytosis" title="Exocytosis">exocytotic</a> vesicles are the means of chemical release at <a href="/wiki/Synapse" title="Synapse">synapses</a>.<a href="#cite_note-Heuser1979-54">[54]</a> <div class="mw-heading mw-heading3"><h3 id="Nuclear_magnetic_resonance_spectroscopy">Nuclear magnetic resonance spectroscopy</h3>[<a href="/w/index.php?title=Lipid_bilayer&action=edit&section=13" title="Edit section: Nuclear magnetic resonance spectroscopy">edit</a>]</div> 31P-<a href="/wiki/Nuclear_magnetic_resonance_spectroscopy" title="Nuclear magnetic resonance spectroscopy">Nuclear magnetic resonance spectroscopy</a> is widely used for studies of phospholipid bilayers and biological membranes in native conditions. The analysis of 31P-NMR spectra of lipids could provide a wide range of information about lipid bilayer packing, phase transitions (gel phase, physiological liquid crystal phase, ripple phases, non bilayer phases), lipid head group orientation/dynamics, and elastic properties of pure lipid bilayer and as a result of binding of proteins and other biomolecules.<a href="#cite_note-Dubinnyi-51">[51]</a> <div class="mw-heading mw-heading3"><h3 id="Atomic_force_microscopy">Atomic force microscopy</h3>[<a href="/w/index.php?title=Lipid_bilayer&action=edit&section=14" title="Edit section: Atomic force microscopy">edit</a>]</div> <figure class="mw-halign-left" typeof="mw:File/Thumb"><a href="/wiki/File:Supported_Lipid_Bilayer_and_Nanoparticles_AFM.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/3/34/Supported_Lipid_Bilayer_and_Nanoparticles_AFM.png/250px-Supported_Lipid_Bilayer_and_Nanoparticles_AFM.png" decoding="async" width="250" height="206" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/34/Supported_Lipid_Bilayer_and_Nanoparticles_AFM.png/375px-Supported_Lipid_Bilayer_and_Nanoparticles_AFM.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/34/Supported_Lipid_Bilayer_and_Nanoparticles_AFM.png/500px-Supported_Lipid_Bilayer_and_Nanoparticles_AFM.png 2x" data-file-width="1220" data-file-height="1003" /></a><figcaption>3d-Adapted <a href="/wiki/Atomic_force_microscope" class="mw-redirect" title="Atomic force microscope">AFM</a> images showing formation of transmembrane pores (holes) in supported lipid bilayer<a href="#cite_note-Lipid_and_nanoparticles-55">[55]</a> </figcaption></figure> <figure class="mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/File:Bilayer_AFM_schematic.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/4/44/Bilayer_AFM_schematic.png/250px-Bilayer_AFM_schematic.png" decoding="async" width="250" height="157" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/44/Bilayer_AFM_schematic.png/375px-Bilayer_AFM_schematic.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/44/Bilayer_AFM_schematic.png/500px-Bilayer_AFM_schematic.png 2x" data-file-width="2391" data-file-height="1503" /></a><figcaption>Illustration of a typical <a href="/wiki/Atomic_force_microscopy" title="Atomic force microscopy">AFM</a> scan of a supported lipid bilayer. The pits are defects in the bilayer, exposing the smooth surface of the substrate underneath.</figcaption></figure> A new method to study lipid bilayers is <a href="/wiki/Atomic_force_microscopy" title="Atomic force microscopy">Atomic force microscopy</a> (AFM). Rather than using a beam of light or particles, a very small sharpened tip scans the surface by making physical contact with the bilayer and moving across it, like a record player needle. AFM is a promising technique because it has the potential to image with nanometer resolution at room temperature and even under water or physiological buffer, conditions necessary for natural bilayer behavior. Utilizing this capability, AFM has been used to examine dynamic bilayer behavior including the formation of transmembrane pores (holes)<a href="#cite_note-Lipid_and_nanoparticles-55">[55]</a> and phase transitions in supported bilayers.<a href="#cite_note-Tokumasu_et_al._2002-56">[56]</a> Another advantage is that AFM does not require fluorescent or <a href="/wiki/Isotope" title="Isotope">isotopic</a> labeling of the lipids, since the probe tip interacts mechanically with the bilayer surface. Because of this, the same scan can image both lipids and associated proteins, sometimes even with single-molecule resolution.<a href="#cite_note-Lipid_and_nanoparticles-55">[55]</a><a href="#cite_note-Richter2003-57">[57]</a> AFM can also probe the mechanical nature of lipid bilayers.<a href="#cite_note-Steltenkamp2006-58">[58]</a> <div class="mw-heading mw-heading3"><h3 id="Dual_polarisation_interferometry">Dual polarisation interferometry</h3>[<a href="/w/index.php?title=Lipid_bilayer&action=edit&section=15" title="Edit section: Dual polarisation interferometry">edit</a>]</div> Lipid bilayers exhibit high levels of <a href="/wiki/Birefringence" title="Birefringence">birefringence</a> where the refractive index in the plane of the bilayer differs from that perpendicular by as much as 0.1 <a href="/wiki/Refractive_index" title="Refractive index">refractive index</a> units. This has been used to characterise the degree of order and disruption in bilayers using <a href="/wiki/Dual_polarisation_interferometry" class="mw-redirect" title="Dual polarisation interferometry">dual polarisation interferometry</a> to understand mechanisms of protein interaction.<a href="#cite_note-Escorihuela_2015-59">[59]</a> <div class="mw-heading mw-heading3"><h3 id="Quantum_chemical_calculations">Quantum chemical calculations</h3>[<a href="/w/index.php?title=Lipid_bilayer&action=edit&section=16" title="Edit section: Quantum chemical calculations">edit</a>]</div> Lipid bilayers are complicated molecular systems with many degrees of freedom. Thus, atomistic simulation of membrane and in particular <a href="/wiki/Ab_initio" title="Ab initio">ab initio</a> calculations of its properties is difficult and computationally expensive. Quantum chemical calculations has recently been successfully performed to estimate <a href="/wiki/Dipole" title="Dipole">dipole</a> and <a href="/wiki/Quadrupole" title="Quadrupole">quadrupole</a> moments of lipid membranes.<a href="#cite_note-60">[60]</a> <div class="mw-heading mw-heading2"><h2 id="Transport_across_the_bilayer">Transport across the bilayer</h2>[<a href="/w/index.php?title=Lipid_bilayer&action=edit&section=17" title="Edit section: Transport across the bilayer">edit</a>]</div> <div class="mw-heading mw-heading3"><h3 id="Passive_diffusion">Passive diffusion</h3>[<a href="/w/index.php?title=Lipid_bilayer&action=edit&section=18" title="Edit section: Passive diffusion">edit</a>]</div> Most <a href="/wiki/Chemical_polarity" title="Chemical polarity">polar</a> molecules have low solubility in the <a href="/wiki/Hydrocarbon" title="Hydrocarbon">hydrocarbon</a> core of a lipid bilayer and, as a consequence, have low permeability coefficients across the bilayer. This effect is particularly pronounced for charged species, which have even lower permeability coefficients than neutral polar molecules.<a href="#cite_note-Chakrabarti1994-61">[61]</a> <a href="/wiki/Anion" class="mw-redirect" title="Anion">Anions</a> typically have a higher rate of diffusion through bilayers than <a href="/wiki/Cation" class="mw-redirect" title="Cation">cations</a>.<a href="#cite_note-Hauser1972-62">[62]</a><a href="#cite_note-Papahadjopoulos1967-63">[63]</a> Compared to ions, water molecules actually have a relatively large permeability through the bilayer, as evidenced by <a href="/wiki/Osmosis" title="Osmosis">osmotic swelling</a>. When a cell or vesicle with a high interior salt concentration is placed in a solution with a low salt concentration it will swell and eventually burst. Such a result would not be observed unless water was able to pass through the bilayer with relative ease. The anomalously large permeability of water through bilayers is still not completely understood and continues to be the subject of active debate.<a href="#cite_note-Paula1996-64">[64]</a> Small uncharged apolar molecules diffuse through lipid bilayers many orders of magnitude faster than ions or water. This applies both to fats and organic solvents like <a href="/wiki/Chloroform" title="Chloroform">chloroform</a> and <a href="/wiki/Diethyl_ether" title="Diethyl ether">ether</a>. Regardless of their polar character larger molecules diffuse more slowly across lipid bilayers than small molecules.<a href="#cite_note-Xiang1994-65">[65]</a> <figure class="mw-default-size mw-halign-left" typeof="mw:File/Thumb"><a href="/wiki/File:1r3j.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/1/18/1r3j.png/220px-1r3j.png" decoding="async" width="220" height="250" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/18/1r3j.png/330px-1r3j.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/18/1r3j.png/440px-1r3j.png 2x" data-file-width="652" data-file-height="741" /></a><figcaption>Structure of a potassium ion channel. The <a href="/wiki/Alpha_helix" title="Alpha helix">alpha helices</a> penetrate the bilayer (between red and blue lines), opening a hole through which potassium ions can flow</figcaption></figure> <div class="mw-heading mw-heading3"><h3 id="Ion_pumps_and_channels">Ion pumps and channels</h3>[<a href="/w/index.php?title=Lipid_bilayer&action=edit&section=19" title="Edit section: Ion pumps and channels">edit</a>]</div> Two special classes of protein deal with the ionic gradients found across cellular and sub-cellular membranes in nature- <a href="/wiki/Ion_channel" title="Ion channel">ion channels</a> and <a href="/wiki/Ion_transporter" title="Ion transporter">ion pumps</a>. Both pumps and channels are <a href="/wiki/Integral_membrane_protein" title="Integral membrane protein">integral membrane proteins</a> that pass through the bilayer, but their roles are quite different. Ion pumps are the proteins that build and maintain the chemical gradients by utilizing an external energy source to move ions against the concentration gradient to an area of higher <a href="/wiki/Chemical_potential" title="Chemical potential">chemical potential</a>. The energy source can be <a href="/wiki/Adenosine_triphosphate" title="Adenosine triphosphate">ATP</a>, as is the case for the <a href="/wiki/NaKATPase" class="mw-redirect" title="NaKATPase">Na+-K+ ATPase</a>. Alternatively, the energy source can be another chemical gradient already in place, as in the <a href="/wiki/Sodium-calcium_exchanger" title="Sodium-calcium exchanger">Ca2+/Na+ antiporter</a>. It is through the action of ion pumps that cells are able to regulate <a href="/wiki/PH" title="PH">pH</a> via the <a href="/wiki/Proton_pump" title="Proton pump">pumping of protons</a>.<a href="#cite_note-Maffeo_2012-66">[66]</a><a href="#cite_note-Purves_2001-67">[67]</a> In contrast to ion pumps, ion channels do not build chemical gradients but rather dissipate them in order to perform work or send a signal. Probably the most familiar and best studied example is the <a href="/wiki/Sodium_channel" title="Sodium channel">voltage-gated Na+ channel</a>, which allows conduction of an <a href="/wiki/Action_potential" title="Action potential">action potential</a> along <a href="/wiki/Neuron" title="Neuron">neurons</a>. All ion pumps have some sort of trigger or “gating” mechanism. In the previous example it was electrical bias, but other channels can be activated by binding a molecular agonist or through a conformational change in another nearby protein.<a href="#cite_note-Gouaux2005-68">[68]</a> <figure class="mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/File:Pinocytosis.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/b/b7/Pinocytosis.svg/210px-Pinocytosis.svg.png" decoding="async" width="210" height="231" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/b7/Pinocytosis.svg/315px-Pinocytosis.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/b7/Pinocytosis.svg/420px-Pinocytosis.svg.png 2x" data-file-width="300" data-file-height="330" /></a><figcaption>Schematic illustration of pinocytosis, a type of endocytosis</figcaption></figure> <div class="mw-heading mw-heading3"><h3 id="Endocytosis_and_exocytosis">Endocytosis and exocytosis</h3>[<a href="/w/index.php?title=Lipid_bilayer&action=edit&section=20" title="Edit section: Endocytosis and exocytosis">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">See also: <a href="/wiki/Endocytosis" title="Endocytosis">Endocytosis</a> and <a href="/wiki/Exocytosis" title="Exocytosis">Exocytosis</a></div> Some molecules or particles are too large or too hydrophilic to pass through a lipid bilayer. Other molecules could pass through the bilayer but must be transported rapidly in such large numbers that channel-type transport is impractical. In both cases, these types of cargo can be moved across the cell membrane through <a href="/wiki/Lipid_bilayer_fusion" title="Lipid bilayer fusion">fusion</a> or budding of <a href="/wiki/Lipid_vesicle" class="mw-redirect" title="Lipid vesicle">vesicles</a>. When a vesicle is produced inside the cell and fuses with the plasma membrane to release its contents into the extracellular space, this process is known as exocytosis. In the reverse process, a region of the cell membrane will dimple inwards and eventually pinch off, enclosing a portion of the extracellular fluid to transport it into the cell. Endocytosis and exocytosis rely on very different molecular machinery to function, but the two processes are intimately linked and could not work without each other. The primary mechanism of this interdependence is the large amount of lipid material involved.<a href="#cite_note-Gundelfinger2003-69">[69]</a> In a typical cell, an area of bilayer equivalent to the entire plasma membrane travels through the endocytosis/exocytosis cycle in about half an hour.<a href="#cite_note-Steinman1976-70">[70]</a> <figure class="mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/File:OMV-macrophage99.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/4/44/OMV-macrophage99.jpg/210px-OMV-macrophage99.jpg" decoding="async" width="210" height="255" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/44/OMV-macrophage99.jpg/315px-OMV-macrophage99.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/44/OMV-macrophage99.jpg/420px-OMV-macrophage99.jpg 2x" data-file-width="443" data-file-height="537" /></a><figcaption>Exocytosis of outer membrane vesicles (MV) liberated from inflated periplasmic pockets (p) on surface of human Salmonella 3,10:r:- pathogens docking on plasma membrane of macrophage cells (M) in chicken ileum, for host-pathogen signaling in vivo.</figcaption></figure> Exocytosis in prokaryotes: Membrane vesicular <a href="/wiki/Exocytosis" title="Exocytosis">exocytosis</a>, popularly known as <a href="/wiki/Membrane_vesicle_trafficking" title="Membrane vesicle trafficking">membrane vesicle trafficking</a>, a Nobel prize-winning (year, 2013) process, is traditionally regarded as a prerogative of <a href="/wiki/Eukaryotic" class="mw-redirect" title="Eukaryotic">eukaryotic</a> cells.<a href="#cite_note-71">[71]</a> This myth was however broken with the revelation that nanovesicles, popularly known as <a href="/wiki/Bacterial_outer_membrane_vesicles" class="mw-redirect" title="Bacterial outer membrane vesicles">bacterial outer membrane vesicles</a>, released by <a href="/wiki/Gram-negative" class="mw-redirect" title="Gram-negative">gram-negative</a> microbes, translocate bacterial signal molecules to host or target cells<a href="#cite_note-72">[72]</a> to carry out multiple processes in favour of the secreting microbe e.g., in host cell invasion<a href="#cite_note-73">[73]</a> and microbe-environment interactions, in general.<a href="#cite_note-74">[74]</a> <div class="mw-heading mw-heading3"><h3 id="Electroporation">Electroporation</h3>[<a href="/w/index.php?title=Lipid_bilayer&action=edit&section=21" title="Edit section: Electroporation">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Further information: <a href="/wiki/Electroporation" title="Electroporation">Electroporation</a></div> Electroporation is the rapid increase in bilayer permeability induced by the application of a large artificial electric field across the membrane. Experimentally, electroporation is used to introduce hydrophilic molecules into cells. It is a particularly useful technique for large highly charged molecules such as <a href="/wiki/DNA" title="DNA">DNA</a>, which would never passively diffuse across the hydrophobic bilayer core.<a href="#cite_note-Neumann1982-75">[75]</a> Because of this, electroporation is one of the key methods of <a href="/wiki/Transfection" title="Transfection">transfection</a> as well as bacterial <a href="/wiki/Transformation_(genetics)" class="mw-redirect" title="Transformation (genetics)">transformation</a>. It has even been proposed that electroporation resulting from <a href="/wiki/Lightning" title="Lightning">lightning</a> strikes could be a mechanism of natural <a href="/wiki/Horizontal_gene_transfer" title="Horizontal gene transfer">horizontal gene transfer</a>.<a href="#cite_note-Demanèche2001-76">[76]</a> <div class="mw-heading mw-heading2"><h2 id="Mechanics">Mechanics</h2>[<a href="/w/index.php?title=Lipid_bilayer&action=edit&section=22" title="Edit section: Mechanics">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Further information: <a href="/wiki/Lipid_bilayer_mechanics" title="Lipid bilayer mechanics">Lipid bilayer mechanics</a></div> <figure typeof="mw:File/Thumb"><a href="/wiki/File:Pore_schematic.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/c/cc/Pore_schematic.svg/280px-Pore_schematic.svg.png" decoding="async" width="280" height="261" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/cc/Pore_schematic.svg/420px-Pore_schematic.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/cc/Pore_schematic.svg/560px-Pore_schematic.svg.png 2x" data-file-width="578" data-file-height="538" /></a><figcaption>Schematic showing two possible conformations of the lipids at the edge of a pore. In the top image the lipids have not rearranged, so the pore wall is hydrophobic. In the bottom image some of the lipid heads have bent over, so the pore wall is hydrophilic.</figcaption></figure> Lipid bilayers are large enough structures to have some of the mechanical properties of liquids or solids. The area compression modulus Ka, bending modulus Kb, and edge energy <math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle \Lambda }"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <mi mathvariant="normal">Λ</mi> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle \Lambda }</annotation> </semantics> </math><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/0ac0a4a98a414e3480335f9ba652d12571ec6733" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.338ex; width:1.613ex; height:2.176ex;" alt="{\displaystyle \Lambda }">, can be used to describe them. Solid lipid bilayers also have a <a href="/wiki/Shear_modulus" title="Shear modulus">shear modulus</a>, but like any liquid, the shear modulus is zero for fluid bilayers. These mechanical properties affect how the membrane functions. Ka and Kb affect the ability of proteins and small molecules to insert into the bilayer,<a href="#cite_note-Garcia2004-77">[77]</a><a href="#cite_note-McIntosh2006-78">[78]</a> and bilayer mechanical properties have been shown to alter the function of mechanically activated ion channels.<a href="#cite_note-Suchyna2004-79">[79]</a> Bilayer mechanical properties also govern what types of stress a cell can withstand without tearing. Although lipid bilayers can easily bend, most cannot stretch more than a few percent before rupturing.<a href="#cite_note-Hallett1993-80">[80]</a> As discussed in the Structure and organization section, the hydrophobic attraction of lipid tails in water is the primary force holding lipid bilayers together. Thus, the elastic modulus of the bilayer is primarily determined by how much extra area is exposed to water when the lipid molecules are stretched apart.<a href="#cite_note-Boal2002-81">[81]</a> It is not surprising given this understanding of the forces involved that studies have shown that Ka varies strongly with <a href="/wiki/Osmotic_pressure" title="Osmotic pressure">osmotic pressure</a><a href="#cite_note-Rutkowski1991-82">[82]</a> but only weakly with tail length and unsaturation.<a href="#cite_note-Rawicz2000-13">[13]</a> Because the forces involved are so small, it is difficult to experimentally determine Ka. Most techniques require sophisticated microscopy and very sensitive measurement equipment.<a href="#cite_note-Steltenkamp2006-58">[58]</a><a href="#cite_note-Evans2003-83">[83]</a> In contrast to Ka, which is a measure of how much energy is needed to stretch the bilayer, Kb is a measure of how much energy is needed to bend or flex the bilayer. Formally, bending modulus is defined as the energy required to deform a membrane from its intrinsic curvature to some other curvature. Intrinsic curvature is defined by the ratio of the diameter of the head group to that of the tail group. For two-tailed PC lipids, this ratio is nearly one so the intrinsic curvature is nearly zero. If a particular lipid has too large a deviation from zero intrinsic curvature it will not form a bilayer and will instead form other phases such as <a href="/wiki/Micelle" title="Micelle">micelles</a> or inverted micelles. Addition of small hydrophilic molecules like sucrose into mixed lipid lamellar liposomes made from galactolipid-rich thylakoid membranes destabilises bilayers into the micellar phase.<a href="#cite_note-84">[84]</a> <math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle \Lambda }"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <mi mathvariant="normal">Λ</mi> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle \Lambda }</annotation> </semantics> </math><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/0ac0a4a98a414e3480335f9ba652d12571ec6733" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.338ex; width:1.613ex; height:2.176ex;" alt="{\displaystyle \Lambda }"> is a measure of how much energy it takes to expose a bilayer edge to water by tearing the bilayer or creating a hole in it. The origin of this energy is the fact that creating such an interface exposes some of the lipid tails to water, but the exact orientation of these border lipids is unknown. There is some evidence that both hydrophobic (tails straight) and hydrophilic (heads curved around) pores can coexist.<a href="#cite_note-Weaver1996-85">[85]</a><a href="#cite_note-86">[86]</a> <div class="mw-heading mw-heading2"><h2 id="Fusion">Fusion</h2>[<a href="/w/index.php?title=Lipid_bilayer&action=edit&section=23" title="Edit section: Fusion">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">See also: <a href="/wiki/Lipid_bilayer_fusion" title="Lipid bilayer fusion">Lipid bilayer fusion</a> and <a href="/wiki/Interbilayer_forces_in_membrane_fusion" title="Interbilayer forces in membrane fusion">Interbilayer forces in membrane fusion</a></div> <figure class="mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/File:Lipid_bilayer_fusion.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/0/05/Lipid_bilayer_fusion.svg/280px-Lipid_bilayer_fusion.svg.png" decoding="async" width="280" height="203" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/05/Lipid_bilayer_fusion.svg/420px-Lipid_bilayer_fusion.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/05/Lipid_bilayer_fusion.svg/560px-Lipid_bilayer_fusion.svg.png 2x" data-file-width="565" data-file-height="409" /></a><figcaption>Illustration of lipid vesicles fusing showing two possible outcomes: hemifusion and full fusion. In hemifusion, only the outer bilayer leaflets mix. In full fusion both leaflets as well as the internal contents mix.</figcaption></figure> <a href="/wiki/Lipid_bilayer_fusion" title="Lipid bilayer fusion">Fusion</a> is the process by which two lipid bilayers merge, resulting in one connected structure.<a href="#cite_note-Chernomordik2003-87">[87]</a> If this fusion proceeds completely through both leaflets of both bilayers, a water-filled bridge is formed and the solutions contained by the bilayers can mix. Alternatively, if only one leaflet from each bilayer is involved in the fusion process, the bilayers are said to be hemifused. Fusion is involved in many cellular processes, in particular in <a href="/wiki/Eukaryote" title="Eukaryote">eukaryotes</a>, since the eukaryotic cell is extensively sub-divided by lipid bilayer membranes. <a href="/wiki/Exocytosis" title="Exocytosis">Exocytosis</a>, <a href="/wiki/Fertilization" class="mw-redirect" title="Fertilization">fertilization</a> of an <a href="/wiki/Egg_(biology)" class="mw-redirect" title="Egg (biology)">egg</a> by <a href="/wiki/Acrosome_reaction" title="Acrosome reaction">sperm activation</a>, and transport of waste products to the <a href="/wiki/Lysozome" class="mw-redirect" title="Lysozome">lysozome</a> are a few of the many eukaryotic processes that rely on some form of fusion. Even the entry of pathogens can be governed by fusion, as many bilayer-coated <a href="/wiki/Virus" title="Virus">viruses</a> have dedicated fusion proteins to gain entry into the host cell.<a href="#cite_note-Chernomordik_1999-88">[88]</a> There are four fundamental steps in the fusion process.<a href="#cite_note-Yeagle1993-36">[36]</a> First, the involved membranes must aggregate, approaching each other to within several nanometers. Second, the two bilayers must come into very close contact (within a few angstroms). To achieve this close contact, the two surfaces must become at least partially dehydrated, as the bound surface water normally present causes bilayers to strongly repel. The presence of ions, in particular divalent cations like magnesium and calcium, strongly affects this step.<a href="#cite_note-Papahadjopoulos1990-89">[89]</a><a href="#cite_note-Leventis1986-90">[90]</a> One of the critical roles of calcium in the body is regulating membrane fusion. Third, a destabilization must form at one point between the two bilayers, locally distorting their structures. The exact nature of this distortion is not known. One theory is that a highly curved "stalk" must form between the two bilayers.<a href="#cite_note-Markin1984-91">[91]</a> Proponents of this theory believe that it explains why phosphatidylethanolamine, a highly curved lipid, promotes fusion. Finally, in the last step of fusion, this point defect grows and the components of the two bilayers mix and diffuse away from the site of contact.<a href="#cite_note-Chernomordik2003-87">[87]</a> <figure class="mw-halign-left" typeof="mw:File/Thumb"><a href="/wiki/File:Membrane_fusion_via_stalk_formation.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/1/1c/Membrane_fusion_via_stalk_formation.jpg/420px-Membrane_fusion_via_stalk_formation.jpg" decoding="async" width="420" height="77" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/1c/Membrane_fusion_via_stalk_formation.jpg/630px-Membrane_fusion_via_stalk_formation.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/1c/Membrane_fusion_via_stalk_formation.jpg/840px-Membrane_fusion_via_stalk_formation.jpg 2x" data-file-width="1096" data-file-height="202" /></a><figcaption>Schematic illustration of the process of fusion through stalk formation.</figcaption></figure> <figure class="mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/File:Exocytosis-machinery.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/90/Exocytosis-machinery.jpg/330px-Exocytosis-machinery.jpg" decoding="async" width="330" height="224" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/90/Exocytosis-machinery.jpg/495px-Exocytosis-machinery.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/90/Exocytosis-machinery.jpg/660px-Exocytosis-machinery.jpg 2x" data-file-width="700" data-file-height="475" /></a><figcaption>Diagram of the action of SNARE proteins docking a vesicle for exocytosis. Complementary versions of the protein on the vesicle and the target membrane bind and wrap around each other, drawing the two bilayers close together in the process.<a href="#cite_note-Georgiev2007-92">[92]</a></figcaption></figure> The situation is further complicated when considering fusion in vivo since biological fusion is almost always regulated by the action of <a href="/wiki/Membrane_protein" title="Membrane protein">membrane-associated proteins</a>. The first of these proteins to be studied were the viral fusion proteins, which allow an enveloped <a href="/wiki/Virus" title="Virus">virus</a> to insert its genetic material into the host cell (enveloped viruses are those surrounded by a lipid bilayer; some others have only a protein coat). <a href="/wiki/Eukaryotic" class="mw-redirect" title="Eukaryotic">Eukaryotic</a> cells also use fusion proteins, the best-studied of which are the <a href="/wiki/SNARE_(protein)" class="mw-redirect" title="SNARE (protein)">SNAREs</a>. SNARE proteins are used to direct all <a href="/wiki/Vesicle_(biology)" class="mw-redirect" title="Vesicle (biology)">vesicular</a> intracellular trafficking. Despite years of study, much is still unknown about the function of this protein class. In fact, there is still an active debate regarding whether SNAREs are linked to early docking or participate later in the fusion process by facilitating hemifusion.<a href="#cite_note-Chen2001-93">[93]</a> In studies of molecular and cellular biology it is often desirable to artificially induce fusion. The addition of <a href="/wiki/Polyethylene_glycol" title="Polyethylene glycol">polyethylene glycol</a> (PEG) causes fusion without significant aggregation or biochemical disruption. This procedure is now used extensively, for example by fusing <a href="/wiki/B-cell" class="mw-redirect" title="B-cell">B-cells</a> with <a href="/wiki/Myeloma" class="mw-redirect" title="Myeloma">myeloma</a> cells.<a href="#cite_note-Kohler1975-94">[94]</a> The resulting “<a href="/wiki/Hybridoma" class="mw-redirect" title="Hybridoma">hybridoma</a>” from this combination expresses a desired <a href="/wiki/Antibody" title="Antibody">antibody</a> as determined by the B-cell involved, but is immortalized due to the melanoma component. Fusion can also be artificially induced through <a href="/wiki/Electroporation" title="Electroporation">electroporation</a> in a process known as electrofusion. It is believed that this phenomenon results from the <a href="/wiki/Lipid_bilayer_mechanics" title="Lipid bilayer mechanics">energetically active edges</a> formed during electroporation, which can act as the local defect point to nucleate stalk growth between two bilayers.<a href="#cite_note-Jordan1989-95">[95]</a> <div class="mw-heading mw-heading2"><h2 id="Model_systems">Model systems</h2>[<a href="/w/index.php?title=Lipid_bilayer&action=edit&section=24" title="Edit section: Model systems">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Model_lipid_bilayers" class="mw-redirect" title="Model lipid bilayers">Model lipid bilayers</a></div> Lipid bilayers can be created artificially in the lab to allow researchers to perform experiments that cannot be done with natural bilayers. They can also be used in the field of <a href="/wiki/Synthetic_biology" title="Synthetic biology">Synthetic Biology</a>, to define the boundaries of <a href="/wiki/Artificial_cell" title="Artificial cell">artificial cells</a>. These synthetic systems are called model lipid bilayers. There are many different types of model bilayers, each having experimental advantages and disadvantages. They can be made with either synthetic or natural lipids. Among the most common model systems are:<a href="#cite_note-96">[96]</a> <ul><li><a href="/wiki/Model_lipid_bilayers#Black_lipid_membranes_(BLM)" class="mw-redirect" title="Model lipid bilayers">Black lipid membranes (BLM)</a></li> <li><a href="/wiki/Model_lipid_bilayers#Supported_lipid_bilayers_(SLB)" class="mw-redirect" title="Model lipid bilayers">Supported lipid bilayers (SLB)</a></li> <li><a href="/wiki/Model_lipid_bilayers#Vesicles" class="mw-redirect" title="Model lipid bilayers">Vesicles</a></li> <li><a href="/wiki/Model_lipid_bilayer" title="Model lipid bilayer">Droplet Interface Bilayers (DIBs)</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="Commercial_applications">Commercial applications</h2>[<a href="/w/index.php?title=Lipid_bilayer&action=edit&section=25" title="Edit section: Commercial applications">edit</a>]</div> To date, the most successful commercial application of lipid bilayers has been the use of <a href="/wiki/Liposome" title="Liposome">liposomes</a> for drug delivery, especially for cancer treatment. (Note- the term “liposome” is in essence synonymous with “<a href="/wiki/Vesicle_(biology)" class="mw-redirect" title="Vesicle (biology)">vesicle</a>” except that vesicle is a general term for the structure whereas liposome refers to only artificial not natural vesicles) The basic idea of liposomal drug delivery is that the drug is encapsulated in solution inside the liposome then injected into the patient. These drug-loaded liposomes travel through the system until they bind at the target site and rupture, releasing the drug. In theory, liposomes should make an ideal drug delivery system since they can isolate nearly any hydrophilic drug, can be grafted with molecules to target specific tissues and can be relatively non-toxic since the body possesses biochemical pathways for <a href="/wiki/Metabolize" class="mw-redirect" title="Metabolize">degrading</a> lipids.<a href="#cite_note-Immordino2006-97">[97]</a> The first generation of drug delivery liposomes had a simple lipid composition and suffered from several limitations. Circulation in the bloodstream was extremely limited due to both <a href="/wiki/Renal" class="mw-redirect" title="Renal">renal</a> clearing and <a href="/wiki/Phagocytosis" title="Phagocytosis">phagocytosis</a>. Refinement of the lipid composition to tune fluidity, surface charge density, and surface hydration resulted in vesicles that adsorb fewer proteins from <a href="/wiki/Blood_serum" class="mw-redirect" title="Blood serum">serum</a> and thus are less readily recognized by the <a href="/wiki/Immune_system" title="Immune system">immune system</a>.<a href="#cite_note-Chonn1992-98">[98]</a> The most significant advance in this area was the grafting of <a href="/wiki/Polyethylene_glycol" title="Polyethylene glycol">polyethylene glycol</a> (PEG) onto the liposome surface to produce “stealth” vesicles, which circulate over long times without immune or renal clearing.<a href="#cite_note-Boris1997-99">[99]</a> The first stealth liposomes were passively targeted at <a href="/wiki/Tumor" class="mw-redirect" title="Tumor">tumor</a> tissues. Because tumors induce rapid and uncontrolled <a href="/wiki/Angiogenesis" title="Angiogenesis">angiogenesis</a> they are especially “leaky” and allow liposomes to exit the bloodstream at a much higher rate than normal tissue would.<a href="#cite_note-Maeda2001-100">[100]</a> More recently[<a href="/wiki/Wikipedia:Manual_of_Style/Dates_and_numbers#Chronological_items" title="Wikipedia:Manual of Style/Dates and numbers">when?</a>] work has been undertaken to graft <a href="/wiki/Antibodies" class="mw-redirect" title="Antibodies">antibodies</a> or other molecular markers onto the liposome surface in the hope of actively binding them to a specific cell or tissue type.<a href="#cite_note-Lopes1999-101">[101]</a> Some examples of this approach are already in clinical trials.<a href="#cite_note-Matsumura2004-102">[102]</a> Another potential application of lipid bilayers is the field of <a href="/wiki/Biosensor" title="Biosensor">biosensors</a>. Since the lipid bilayer is the barrier between the interior and exterior of the cell, it is also the site of extensive signal transduction. Researchers over the years have tried to harness this potential to develop a bilayer-based device for clinical diagnosis or bioterrorism detection. Progress has been slow in this area and, although a few companies have developed automated lipid-based detection systems, they are still targeted at the research community. These include Biacore (now GE Healthcare Life Sciences), which offers a disposable chip for utilizing lipid bilayers in studies of binding kinetics<a href="#cite_note-Biacore-103">[103]</a> and Nanion Inc., which has developed an <a href="/wiki/Planar_patch_clamp" class="mw-redirect" title="Planar patch clamp">automated patch clamping</a> system.<a href="#cite_note-104">[104]</a> A supported lipid bilayer (SLB) as described above has achieved commercial success as a screening technique to measure the permeability of drugs. This parallel artificial membrane permeability assay (<a href="/wiki/PAMPA" class="mw-redirect" title="PAMPA">PAMPA</a>) technique measures the permeability across specifically formulated lipid cocktail(s) found to be highly correlated with <a href="/wiki/Caco-2" title="Caco-2">Caco-2</a> cultures,<a href="#cite_note-105">[105]</a><a href="#cite_note-106">[106]</a> the <a href="/wiki/Gastrointestinal_tract" title="Gastrointestinal tract">gastrointestinal tract</a>,<a href="#cite_note-107">[107]</a> <a href="/wiki/Blood%E2%80%93brain_barrier" title="Blood–brain barrier">blood–brain barrier</a><a href="#cite_note-108">[108]</a> and skin.<a href="#cite_note-109">[109]</a> <div class="mw-heading mw-heading2"><h2 id="History">History</h2>[<a href="/w/index.php?title=Lipid_bilayer&action=edit&section=26" title="Edit section: History">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Further information: <a href="/wiki/History_of_cell_membrane_theory" title="History of cell membrane theory">History of cell membrane theory</a></div> By the early twentieth century scientists had come to believe that cells are surrounded by a thin oil-like barrier,<a href="#cite_note-Loeb1904-110">[110]</a> but the structural nature of this membrane was not known. Two experiments in 1925 laid the groundwork to fill in this gap. By measuring the <a href="/wiki/Capacitance" title="Capacitance">capacitance</a> of <a href="/wiki/Erythrocyte" class="mw-redirect" title="Erythrocyte">erythrocyte</a> solutions, Hugo Fricke determined that the cell membrane was 3.3 nm thick.<a href="#cite_note-Fricke1925-111">[111]</a> Although the results of this experiment were accurate, Fricke misinterpreted the data to mean that the cell membrane is a single molecular layer. Prof. Dr. Evert Gorter<a href="#cite_note-Gorterbio-112">[112]</a> (1881–1954) and F. Grendel of Leiden University approached the problem from a different perspective, spreading the erythrocyte lipids as a monolayer on a <a href="/wiki/Langmuir-Blodgett_trough" class="mw-redirect" title="Langmuir-Blodgett trough">Langmuir-Blodgett trough</a>. When they compared the area of the monolayer to the surface area of the cells, they found a ratio of two to one.<a href="#cite_note-Gorter1925-113">[113]</a> Later analyses showed several errors and incorrect assumptions with this experiment but, serendipitously, these errors canceled out and from this flawed data Gorter and Grendel drew the correct conclusion- that the cell membrane is a lipid bilayer.<a href="#cite_note-Yeagle1993-36">[36]</a> This theory was confirmed through the use of <a href="/wiki/Electron_microscopy" class="mw-redirect" title="Electron microscopy">electron microscopy</a> in the late 1950s. Although he did not publish the first electron microscopy study of lipid bilayers<a href="#cite_note-Sjöstrand1958-114">[114]</a> J. David Robertson was the first to assert that the two dark electron-dense bands were the headgroups and associated proteins of two apposed lipid monolayers. In this body of work, Robertson put forward the concept of the “unit membrane.” This was the first time the bilayer structure had been universally assigned to all cell membranes as well as <a href="/wiki/Organelle" title="Organelle">organelle</a> membranes.<a href="#cite_note-Robertson1960-115">[115]</a><a href="#cite_note-Robertson1959-116">[116]</a> Around the same time, the development of model membranes confirmed that the lipid bilayer is a stable structure that can exist independent of proteins. By “painting” a solution of lipid in organic solvent across an aperture, Mueller and Rudin were able to create an artificial bilayer and determine that this exhibited lateral fluidity, high electrical resistance and self-healing in response to puncture,<a href="#cite_note-Mueller1962-117">[117]</a> all of which are properties of a natural cell membrane. A few years later, <a href="/wiki/Alec_Douglas_Bangham" class="mw-redirect" title="Alec Douglas Bangham">Alec Bangham</a> showed that bilayers, in the form of lipid vesicles, could also be formed simply by exposing a dried lipid sample to water. This demonstrated that lipid bilayers form spontaneously via <a href="/wiki/Self_assembly" class="mw-redirect" title="Self assembly">self assembly</a> and do not require a patterned support structure.<a href="#cite_note-Bangham1964-118">[118]</a> In 1977, a totally synthetic bilayer membrane was prepared by Kunitake and Okahata, from a single organic compound, didodecyldimethylammonium bromide. This showed that the bilayer membrane was assembled by the <a href="/wiki/Intermolecular_force" title="Intermolecular force">intermolecular forces</a>.<a href="#cite_note-Kunitake1977-119">[119]</a> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2>[<a href="/w/index.php?title=Lipid_bilayer&action=edit&section=27" title="Edit section: See also">edit</a>]</div> <ul><li><a href="/wiki/Surfactant" title="Surfactant">Surfactant</a></li> <li><a href="/wiki/Membrane_biophysics" class="mw-redirect" title="Membrane biophysics">Membrane biophysics</a></li> <li><a href="/wiki/Lipid_polymorphism" title="Lipid polymorphism">Lipid polymorphism</a></li> <li><a href="/wiki/Lipidomics" title="Lipidomics">Lipidomics</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2>[<a href="/w/index.php?title=Lipid_bilayer&action=edit&section=28" title="Edit section: References">edit</a>]</div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width reflist-columns-2"> <ol class="references"> <li id="cite_note-1"><a href="#cite_ref-1">^</a> <style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFGaspar_Banfalvi2016" class="citation book cs1">Gaspar Banfalvi (2016). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=EZCRCwAAQBAJ&pg=PA19">Permeability of Biological Membranes</a>. Springer. p. 19. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-3-319-28098-1" title="Special:BookSources/978-3-319-28098-1"><bdi>978-3-319-28098-1</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Permeability+of+Biological+Membranes&rft.pages=19&rft.pub=Springer&rft.date=2016&rft.isbn=978-3-319-28098-1&rft.au=Gaspar+Banfalvi&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DEZCRCwAAQBAJ%26pg%3DPA19&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALipid+bilayer" class="Z3988"> </li> <li id="cite_note-andersen2007-2"><a href="#cite_ref-andersen2007_2-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFAndersenKoeppe,_II2007" class="citation journal cs1">Andersen, Olaf S.; Koeppe, II, Roger E. (June 2007). "Bilayer Thickness and Membrane Protein Function: An Energetic Perspective". 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