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In Rodents</a></li> <li><a href="https://www.compbio.com/subcutaneous-implants-video/">Subcutaneous Implants + Video</a></li> </ul> </li> </ul> </div> </div> </div> <div id="primary" class="content-area medium-9 columns"> <div class="header-title"> <h1 class="entry-title">Bladder Cancer</h1> </div> <main id="main" class="site-main" role="main"> <article id="post-4961" class="post-4961 post type-post status-publish format-standard hentry category-general"> <div id="breadcrumb"> <div id="crumbs"><span class="crumb"><a href="https://www.compbio.com">Home</a></span> <i class="fa fa-angle-right"></i> <span class="crumb"><a href="https://www.compbio.com/general/">General</a></span> <i class="fa fa-angle-right"></i> <span class="current">Bladder Cancer</span></div> </div> <div class="entry-content"> <div class="the-content-contain"> <div class="row builder-row content-row"> <div class="medium-12 columns"> <p> </p> <p><img class="size-full wp-image-4976 alignleft" src="https://www.compbio.com/images/CBI-Bladder-Image1.jpg?v=1713386002" alt="" width="948" height="451" srcset="https://www.compbio.com/images/CBI-Bladder-Image1.jpg?v=1713386002 948w, https://www.compbio.com/images/CBI-Bladder-Image1-300x143.jpg?v=1713386011 300w, https://www.compbio.com/images/CBI-Bladder-Image1-768x365.jpg?v=1713386016 768w" sizes="(max-width: 948px) 100vw, 948px"></p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <h3><strong>Intravesicular Toxicology, Pharmacokinetics and Efficacy Studies at CBI</strong></h3> <p>Bladder cancer generally effects older men.  Most bladder cancers start in the innermost lining of the bladder, which is called the urothelium or transitional epithelium. As the carcinoma grows into or through the other layers in the bladder wall, it has a higher stage, becomes more advanced, and can be harder to treat.  Over time, the cancer might grow outside the bladder and into nearby structures. It might spread to nearby lymph nodes, or to other parts of the body. (When bladder cancer spreads, it tends to go to distant lymph nodes, the bones, the lungs, or the liver.)  Common tumors include transitional cell carcinoma, squamous cell carcinoma, sarcomas, adenocarcinoma, and small cell carcinoma.</p> <p>Intravesicular dosing with cancer chemotherapeutic agents is an important and effective route of administration in patients undergoing treatment for bladder cancer.  New drug candidates are assessed in preclinical and toxicology studies using this route of administration.  Mice, rats and dogs are commonly used for these assessments.  This route requires highly skilled methodology to administer the test article without traumatizing the bladder.</p> <p>In the treatment of bladder cancer, traditional chemotherapeutics such as cisplatin, gemcytobine, carboplatin, methotrexate, vinblastine, doxorubicin are often used.  More recently, immunomodulators such as BCG and interferon are used locally.</p> <p>A new class of agents, <strong>Immunomodulators</strong> and <strong>Immune Checkpoint Inhibitors</strong>  that block a protein called <strong>PD-1 </strong>is under intense assessment.  <strong>PD-1</strong> is found on the surface of T cells, which are a type of white blood cell that directly helps the body’s immune system fight disease are newly approved or undergoing FDA assessment.  Targeted therapies and anti-tumor viral vaccines are in development.</p> <p>At CBI we conduct <strong>intravesicular toxicology, pharmacokinetics and efficacy studies </strong>using this difficult route of administration in these species.  We are experienced with new treatment modalities including <strong>Anti-tumor Viral Vaccines,</strong> <strong>Immunomodulators</strong> and <strong>Immune Checkpoint Inhibitors</strong> in both normal tumor bearing, xenografted, syngeneic and orthotopic rodents.   We also conducted pharmacokinetic studies via traditional and intravesicular routes and both toxicology and efficacy assessments.</p> <p> </p> <p><span class="ILfuVd NA6bn"><span class="hgKElc"><b>*CBI Note: Singer, Kenny Rogers died</b> at age 81 from natural <b>causes</b> at home in Georgia, his rep confirmed in a statement. <b>Rogers</b> passed away peacefully at home from natural <b>causes</b> under the care of hospice and surrounded by his family. According to Radar Online in May of 2019, then-80-year-old Kenny Rogers was battling <b>bladder cancer</b> — the same disease that caused him to retire from the public eye in 2018.</span></span></p> <p> </p> <p><strong>Contact Comparative Biosciences, Inc. to discuss a scientific study program for Bladder Cancer Studies and Services.</strong></p> <p><strong>Comparative Biosciences, Inc.    ·    Phone: 408.738.9260</strong></p> <p> </p> <p><span style="color: #008080;">– CUSTOM INTRAVESICULAR TOXICOLOGY, PHARMACOKINETICS AND EFFICACY STUDIES UPON REQUEST –</span></p> </div> </div> </div> </div> </article> </main> </div> </div> <div class="call-out"> <h3 class="content-left"><span class="line-one">Have a question</span> <span class="line-two">or need a quote?</span></h3> <svg version="1.1" id="Layer_1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 100 85" style="enable-background:new 0 0 100 85;" xml:space="preserve"> <style type="text/css"> .st0{fill:#FFFFFF;} </style> <g> <path class="st0" d="M64.3,0.5H16c-8.8,0-16,7.2-16,16V44c0,8.4,6.6,15.4,14.9,16l-3.7,17.4L31.6,60h8.8V43.9 c0-8.7,7.1-15.8,15.8-15.8h24.2V16.5C80.3,7.7,73.1,0.5,64.3,0.5z"/> <path class="st0" d="M89.1,33h-33c-6,0-10.9,4.9-10.9,10.9v18.8c0,6,4.9,10.9,10.9,10.9h22.4l13.9,11.8l-2.5-11.9 c5.7-0.4,10.2-5.1,10.2-10.9V44C100,38,95.1,33,89.1,33z M85.5,49.3c2.2,0,4,1.8,4,4.1c0,2.2-1.8,4.1-4,4.1s-4-1.8-4-4.1 C81.5,51.1,83.3,49.3,85.5,49.3z M59.6,57.4c-2.2,0-4-1.8-4-4.1c0-2.2,1.8-4.1,4-4.1c2.2,0,4,1.8,4,4.1 C63.7,55.6,61.9,57.4,59.6,57.4z M68.5,53.4c0-2.2,1.8-4.1,4-4.1s4,1.8,4,4.1c0,2.2-1.8,4.1-4,4.1S68.5,55.6,68.5,53.4z"/> </g> </svg> <h3 class="content-right"><span>We can help!</span> <a href="https://www.compbio.com/contact-us/"><span class="cta-btn">Contact us</span></a></h3> </div> </div> </div> <footer id="colophon" class="site-footer row"> <div class="site-info medium-12 columns"> Comparative Biosciences, Inc. · <strong>Phone: 888-994-4879</strong><br> Copyright 2024 Comparative Biosciences, Inc. 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