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Asser</title> <meta name="description" content="Search results for: Elsheikh Asser"> <meta name="keywords" content="Elsheikh Asser"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Elsheikh Asser"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 11</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Elsheikh Asser</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">11</span> Genetic Algorithms Multi-Objective Model for Project Scheduling</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Elsheikh%20Asser">Elsheikh Asser</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Time and cost are the main goals of the construction project management. The first schedule developed may not be a suitable schedule for beginning or completing the project to achieve the target completion time at a minimum total cost. In general, there are trade-offs between time and cost (TCT) to complete the activities of a project. This research presents genetic algorithms (GAs) multi-objective model for project scheduling considering different scenarios such as least cost, least time, and target time. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=genetic%20algorithms" title="genetic algorithms">genetic algorithms</a>, <a href="https://publications.waset.org/abstracts/search?q=time-cost%20trade-off" title=" time-cost trade-off"> time-cost trade-off</a>, <a href="https://publications.waset.org/abstracts/search?q=multi-objective%20model" title=" multi-objective model"> multi-objective model</a>, <a href="https://publications.waset.org/abstracts/search?q=project%20scheduling" title=" project scheduling"> project scheduling</a> </p> <a href="https://publications.waset.org/abstracts/16242/genetic-algorithms-multi-objective-model-for-project-scheduling" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/16242.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">413</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">10</span> 2D Numerical Modeling for Induced Current Distribution in Soil under Lightning Impulse Discharge</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Fawwaz%20Eniola%20Fajingbesi">Fawwaz Eniola Fajingbesi</a>, <a href="https://publications.waset.org/abstracts/search?q=Nur%20Shahida%20Midia"> Nur Shahida Midia</a>, <a href="https://publications.waset.org/abstracts/search?q=Elsheikh%20M.%20A.%20Elsheikh"> Elsheikh M. A. Elsheikh</a>, <a href="https://publications.waset.org/abstracts/search?q=Siti%20Hajar%20Yusoff"> Siti Hajar Yusoff</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Empirical analysis of lightning related phenomena in real time is extremely dangerous due to the relatively high electric discharge involved. Hence, design and optimization of efficient grounding systems depending on real time empirical methods are impeded. Using numerical methods, the dynamics of complex systems could be modeled hence solved as sets of linear and non-linear systems . In this work, the induced current distribution as lightning strike traverses the soil have been numerically modeled in a 2D axial-symmetry and solved using finite element method (FEM) in COMSOL Multiphysics 5.2 AC/DC module. Stratified and non- stratified electrode system were considered in the solved model and soil conductivity (σ) varied between 10 – 58 mS/m. The result discussed therein were the electric field distribution, current distribution and soil ionization phenomena. It can be concluded that the electric field and current distribution is influenced by the injected electric potential and the non-linearity in soil conductivity. The result from numerical calculation also agrees with previously laboratory scale empirical results. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=current%20distribution" title="current distribution">current distribution</a>, <a href="https://publications.waset.org/abstracts/search?q=grounding%20systems" title=" grounding systems"> grounding systems</a>, <a href="https://publications.waset.org/abstracts/search?q=lightning%20discharge" title=" lightning discharge"> lightning discharge</a>, <a href="https://publications.waset.org/abstracts/search?q=numerical%20model" title=" numerical model"> numerical model</a>, <a href="https://publications.waset.org/abstracts/search?q=soil%20conductivity" title=" soil conductivity"> soil conductivity</a>, <a href="https://publications.waset.org/abstracts/search?q=soil%20ionization" title=" soil ionization"> soil ionization</a> </p> <a href="https://publications.waset.org/abstracts/89250/2d-numerical-modeling-for-induced-current-distribution-in-soil-under-lightning-impulse-discharge" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/89250.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">312</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">9</span> Energy Management System with Temperature Rise Prevention on Hybrid Ships</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Asser%20S.%20Abdelwahab">Asser S. Abdelwahab</a>, <a href="https://publications.waset.org/abstracts/search?q=Nabil%20H.%20Abbasy"> Nabil H. Abbasy</a>, <a href="https://publications.waset.org/abstracts/search?q=Ragi%20A.%20Hamdy"> Ragi A. Hamdy</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Marine shipping has now become one of the major worldwide contributors to pollution and greenhouse gas emissions. Hybrid ships technology based on multiple energy sources has taken a great scope of research to get rid of ship emissions and cut down fuel expenses. Insufficiency between power generated and the demand load to withstand the transient behavior on ships during severe climate conditions will lead to a blackout. Thus, an efficient energy management system (EMS) is a mandatory scope for achieving higher system efficiency while enhancing the lifetime of the onboard storage systems is another salient EMS scope. Considering energy storage system conditions, both the battery state of charge (SOC) and temperature represent important parameters to prevent any malfunction of the storage system that eventually degrades the whole system. In this paper, a two battery packs ratio fuzzy logic control model is proposed. The overall aim is to control the charging/discharging current while including both the battery SOC and temperature in the energy management system. The full designs of the proposed controllers are described and simulated using Matlab. The results prove the successfulness of the proposed controller in stabilizing the system voltage during both loading and unloading while keeping the energy storage system in a healthy condition. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=energy%20storage%20system" title="energy storage system">energy storage system</a>, <a href="https://publications.waset.org/abstracts/search?q=power%20shipboard" title=" power shipboard"> power shipboard</a>, <a href="https://publications.waset.org/abstracts/search?q=hybrid%20ship" title=" hybrid ship"> hybrid ship</a>, <a href="https://publications.waset.org/abstracts/search?q=thermal%20runaway" title=" thermal runaway"> thermal runaway</a> </p> <a href="https://publications.waset.org/abstracts/143081/energy-management-system-with-temperature-rise-prevention-on-hybrid-ships" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/143081.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">201</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">8</span> Resident-Aware Green Home</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ahlam%20Elkilani">Ahlam Elkilani</a>, <a href="https://publications.waset.org/abstracts/search?q=Bayan%20Elsheikh%20Ali"> Bayan Elsheikh Ali</a>, <a href="https://publications.waset.org/abstracts/search?q=Rasha%20Abu%20Romman"> Rasha Abu Romman</a>, <a href="https://publications.waset.org/abstracts/search?q=Amjed%20Al-mousa"> Amjed Al-mousa</a>, <a href="https://publications.waset.org/abstracts/search?q=Belal%20Sababha"> Belal Sababha</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The amount of energy the world uses doubles every 20 years. Green homes play an important role in reducing the residential energy demand. This paper presents a platform that is intended to learn the behavior of home residents and build a profile about their habits and actions. The proposed resident aware home controller intervenes in the operation of home appliances in order to save energy without compromising the convenience of the residents. The presented platform can be used to simulate the actions and movements happening inside a home. The paper includes several optimization techniques that are meant to save energy in the home. In addition, several test scenarios are presented that show how the controller works. Moreover, this paper shows the computed actual savings when each of the presented techniques is implemented in a typical home. The test scenarios have validated that the techniques developed are capable of effectively saving energy at homes. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=green%20home" title="green home">green home</a>, <a href="https://publications.waset.org/abstracts/search?q=resident%20aware" title=" resident aware"> resident aware</a>, <a href="https://publications.waset.org/abstracts/search?q=resident%20profile" title=" resident profile"> resident profile</a>, <a href="https://publications.waset.org/abstracts/search?q=activity%20learning" title=" activity learning"> activity learning</a>, <a href="https://publications.waset.org/abstracts/search?q=machine%20learning" title=" machine learning"> machine learning</a> </p> <a href="https://publications.waset.org/abstracts/10045/resident-aware-green-home" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/10045.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">389</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7</span> Crop Water Productivity for Sunflower under Different Irrigation Regimes and Plant Spacing, at Gezira Clay Soil, Sudan</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=R.%20A.%20Eman%20Elsheikh">R. A. Eman Elsheikh</a>, <a href="https://publications.waset.org/abstracts/search?q=Bart%20Schultz"> Bart Schultz</a>, <a href="https://publications.waset.org/abstracts/search?q=Abraham%20Mehari%20Haile"> Abraham Mehari Haile</a>, <a href="https://publications.waset.org/abstracts/search?q=Hussein%20S.%20Adam"> Hussein S. Adam</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A field experiment was conducted at Gezira research station farm during the winter season in the third week of November 2012, in WadMedani, Sudan (Lat 14.23 W, Long 33.39 E and altitude 405 m above sea level, in deep cracking alkaline heavy clay Vertisols). The objective of this study was to determine the effect of three different irrigation for 10 days (W1), 15 days (W2) and 20 days (W3) and for two rows of 30 cm (S1) and 40 cm (S2), respectively. The experimental design was split plot with three replicates. The sunflower test variety was Hysun 33 cultivar. The seasonal water applied during the study was 6898, 6647, 5256, 5435, 5214, 5416 m3/ha for W1S1, W1S2, W2S1, W2S2, W3S1 and W3S2 respectively. The seed yield obtained for the above treatment in that sequence was 4208, 5542, 5167, 4579, 2931, 2936 kg/ha. The corresponding computed water productivity was 0.61, 0.82, 0.87, 0.95, 0.54, 0.56 kg/m3. The study clearly indicated that the highest seed yield was obtained when the crop was sown at 40 cm row spacing and was irrigated every 10 days (W1S2), followed by W2S1. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=water%20productivity" title="water productivity">water productivity</a>, <a href="https://publications.waset.org/abstracts/search?q=water%20deficit" title=" water deficit"> water deficit</a>, <a href="https://publications.waset.org/abstracts/search?q=sunflower" title=" sunflower"> sunflower</a>, <a href="https://publications.waset.org/abstracts/search?q=plant%20spacing" title=" plant spacing"> plant spacing</a> </p> <a href="https://publications.waset.org/abstracts/6521/crop-water-productivity-for-sunflower-under-different-irrigation-regimes-and-plant-spacing-at-gezira-clay-soil-sudan" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/6521.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">349</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">6</span> Coupled Spacecraft Orbital and Attitude Modeling and Simulation in Multi-Complex Modes</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Amr%20Abdel%20Azim%20Ali">Amr Abdel Azim Ali</a>, <a href="https://publications.waset.org/abstracts/search?q=G.%20A.%20Elsheikh"> G. A. Elsheikh</a>, <a href="https://publications.waset.org/abstracts/search?q=Moutaz%20Hegazy"> Moutaz Hegazy</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This paper presents verification of a modeling and simulation for a Spacecraft (SC) attitude and orbit control system. Detailed formulation of coupled SC orbital and attitude equations of motion is performed in order to achieve accepted accuracy to meet the requirements of multitargets tracking and orbit correction complex modes. Correction of the target parameter based on the estimated state vector during shooting time to enhance pointing accuracy is considered. Time-optimal nonlinear feedback control technique was used in order to take full advantage of the maximum torques that the controller can deliver. This simulation provides options for visualizing SC trajectory and attitude in a 3D environment by including an interface with V-Realm Builder and VR Sink in Simulink/MATLAB. Verification data confirms the simulation results, ensuring that the model and the proposed control law can be used successfully for large and fast tracking and is robust enough to keep the pointing accuracy within the desired limits with considerable uncertainty in inertia and control torque. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=attitude%20and%20orbit%20control" title="attitude and orbit control">attitude and orbit control</a>, <a href="https://publications.waset.org/abstracts/search?q=time-optimal%20nonlinear%20feedback%20control" title=" time-optimal nonlinear feedback control"> time-optimal nonlinear feedback control</a>, <a href="https://publications.waset.org/abstracts/search?q=modeling%20and%20simulation" title=" modeling and simulation"> modeling and simulation</a>, <a href="https://publications.waset.org/abstracts/search?q=pointing%20accuracy" title=" pointing accuracy"> pointing accuracy</a>, <a href="https://publications.waset.org/abstracts/search?q=maximum%20torques" title=" maximum torques"> maximum torques</a> </p> <a href="https://publications.waset.org/abstracts/59362/coupled-spacecraft-orbital-and-attitude-modeling-and-simulation-in-multi-complex-modes" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/59362.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">332</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5</span> Modeling of the Attitude Control Reaction Wheels of a Spacecraft in Software in the Loop Test Bed</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Amr%20AbdelAzim%20Ali">Amr AbdelAzim Ali</a>, <a href="https://publications.waset.org/abstracts/search?q=G.%20A.%20Elsheikh"> G. A. Elsheikh</a>, <a href="https://publications.waset.org/abstracts/search?q=Moutaz%20M.%20Hegazy"> Moutaz M. Hegazy</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Reaction wheels (RWs) are generally used as main actuator in the attitude control system (ACS) of spacecraft (SC) for fast orientation and high pointing accuracy. In order to achieve the required accuracy for the RWs model, the main characteristics of the RWs that necessitate analysis during the ACS design phase include: technical features, sequence of operating and RW control logic are included in function (behavior) model. A mathematical model is developed including the various errors source. The errors in control torque including relative, absolute, and error due to time delay. While the errors in angular velocity due to differences between average and real speed, resolution error, loose in installation of angular sensor, and synchronization errors. The friction torque is presented in the model include the different feature of friction phenomena: steady velocity friction, static friction and break-away torque, and frictional lag. The model response is compared with the experimental torque and frequency-response characteristics of tested RWs. Based on the created RW model, some criteria of optimization based control torque allocation problem can be recommended like: avoiding the zero speed crossing, bias angular velocity, or preventing wheel from running on the same angular velocity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=friction%20torque" title="friction torque">friction torque</a>, <a href="https://publications.waset.org/abstracts/search?q=reaction%20wheels%20modeling" title=" reaction wheels modeling"> reaction wheels modeling</a>, <a href="https://publications.waset.org/abstracts/search?q=software%20in%20the%20loop" title=" software in the loop"> software in the loop</a>, <a href="https://publications.waset.org/abstracts/search?q=spacecraft%20attitude%20control" title=" spacecraft attitude control"> spacecraft attitude control</a> </p> <a href="https://publications.waset.org/abstracts/86635/modeling-of-the-attitude-control-reaction-wheels-of-a-spacecraft-in-software-in-the-loop-test-bed" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/86635.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">266</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4</span> Seam Slippage of Light Woven Fabrics with Regards to Sewing Parameters</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mona%20Shawky">Mona Shawky</a>, <a href="https://publications.waset.org/abstracts/search?q=Khaled%20M.%20Elsheikh"> Khaled M. Elsheikh</a>, <a href="https://publications.waset.org/abstracts/search?q=Heba%20M.%20Darwish"> Heba M. Darwish</a>, <a href="https://publications.waset.org/abstracts/search?q=Eman%20Abd%20El%20Elsamea"> Eman Abd El Elsamea</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Seams are the basic component in the structure of any apparel. The seam quality of the garment is a term that indicates both the aesthetic and functional performance of the garment. Seam slippage is one of the important properties that determine garment performance. Lightweight fabrics are preferred for their aesthetic properties. Since seam slippage is one of the most occurable faults for woven garments, in this study, a design of experiment of the following sewing parameters (three levels of needle size, three levels of stitch density, three levels of the seam allowance, two levels of sewing thread count, and two fabric types) was used to obtain the effect of the interaction between different sewing parameters on-seam slippage force. Two lightweight polyester woven fabrics with different constructions were used with lock stitch 301 to perform this study. Regression equations which can predict seam slippage force in both warp and weft directions were concluded. It was found that fabric type has a significant positive effect on seam slippage force in the warp direction, while it has a significant negative effect on seam slippage force on weft direction. Also, the interaction between needle size and stitch density has a significant positive effect on seam slippage force on warp direction, while the interaction between stitch density and seam allowance has a negative effect on seam slippage force in the weft direction. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=needle%20size" title="needle size">needle size</a>, <a href="https://publications.waset.org/abstracts/search?q=regression%20equation" title=" regression equation"> regression equation</a>, <a href="https://publications.waset.org/abstracts/search?q=seam%20allowance" title=" seam allowance"> seam allowance</a>, <a href="https://publications.waset.org/abstracts/search?q=seam%20slippage" title=" seam slippage"> seam slippage</a>, <a href="https://publications.waset.org/abstracts/search?q=stitch%20density" title=" stitch density"> stitch density</a> </p> <a href="https://publications.waset.org/abstracts/128316/seam-slippage-of-light-woven-fabrics-with-regards-to-sewing-parameters" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/128316.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">160</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> STAT6 Mediates Local and Systemic Fibrosis and Type Ii Immune Response via Macrophage Polarization during Acute and Chronic Pancreatitis in Murine Model</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hager%20Elsheikh">Hager Elsheikh</a>, <a href="https://publications.waset.org/abstracts/search?q=Matthias%20Sendler"> Matthias Sendler</a>, <a href="https://publications.waset.org/abstracts/search?q=Juliana%20Glaubnitz"> Juliana Glaubnitz</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In pancreatitis, an inflammatory reaction occurs in the pancreatic secretory cells due to premature activation of proteases, leading to pancreatic self-digestion and necrotic cell death of acinar cells. Acute pancreatitis in patients is characterized by a severe immune reaction that could lead to serious complications, such as organ failure or septic shock, if left untreated. Chronic pancreatitis is a recurrence of episodes of acute pancreatitis resulting in a fibro-inflammatory immune response, in which the type 2 immune response is primarily driven by AAMs in the pancreas. One of the most important signaling pathways for M2 macrophage activation is the IL-4/STAT6 pathway. Pancreatic fibrosis is induced by the hyperactivation of pancreatic stellate cells by dysregulation in the inflammatory response, leading to further damage, autodigestion and possibly necrosis of pancreatic acinar cells. The aim of this research is to investigate the effect of STAT6 knockout in disease severity and development of fibrosis wound healing in the presence of different macrophage populations, regulated by the type 2 immune response, after inducing chronic and/or acute pancreatitis in mice models via cerulean injection. We further investigate the influence of the JAK/STAT6 signaling pathway on the balance of fibrosis and regeneration in STAT6 deficient and wild-type mice. The characterization of resident and recruited macrophages will provide insight into the influence of the JAK/STAT6 signaling pathway on infiltrating cells and, ultimately, tissue fibrosis and disease severity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=acute%20and%20chronic%20pancreatitis" title="acute and chronic pancreatitis">acute and chronic pancreatitis</a>, <a href="https://publications.waset.org/abstracts/search?q=tissue%20regeneration" title=" tissue regeneration"> tissue regeneration</a>, <a href="https://publications.waset.org/abstracts/search?q=macrophage%20polarization" title=" macrophage polarization"> macrophage polarization</a>, <a href="https://publications.waset.org/abstracts/search?q=Gastroenterology" title=" Gastroenterology"> Gastroenterology</a> </p> <a href="https://publications.waset.org/abstracts/173320/stat6-mediates-local-and-systemic-fibrosis-and-type-ii-immune-response-via-macrophage-polarization-during-acute-and-chronic-pancreatitis-in-murine-model" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/173320.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">68</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> IL4/IL13 STAT6 Mediated Macrophage Polarization During Acute and Chronic Pancreatitis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hager%20Elsheikh">Hager Elsheikh</a>, <a href="https://publications.waset.org/abstracts/search?q=Juliane%20Glaubitz"> Juliane Glaubitz</a>, <a href="https://publications.waset.org/abstracts/search?q=Frank%20Ulrich%20Weiss"> Frank Ulrich Weiss</a>, <a href="https://publications.waset.org/abstracts/search?q=Matthias%20Sendler"> Matthias Sendler</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Aim: Acute pancreatitis (AP) and chronic pancreatitis (CP) are both accompanied by a prominent immune response which influences the course of disease. Whereas during AP the pro-inflammatory immune response dominates, during CP a fibroinflammatory response regulates organ remodeling. The transcription factor signal transducer and activator of transcription 6 (STAT6) is a crucial part of the Type 2 immune response. Here we investigate the role of STAT6 in a mouse model of AP and CP. Material and Methods: AP was induced by hourly repetitive i.p. injections of caerulein (50µg/kg/bodyweight) in C57Bl/6 J and STAT6-/- mice. CP was induced by repetitive caerulein injections 6 times a day, 3 days a week over 4 weeks. Disease severity was evaluated by serum amylase/lipase measurement, H&E staining of pancreas. Pancreatic infiltrate was characterized by immunofluorescent labeling of CD68, CD206, CCR2, CD4 and CD8. Pancreas fibrosis was evaluated by Azan blue staining. qRT-PCR was performed of Arg1, Nos2, Il6, Il1b, Col3a, Socs3 and Ym1. Affymetrix chip array analyses were done to illustrate the IL4/IL13/STAT6 signaling in bone marrow derived macrophages. Results: AP severity is mitigated in STAT6-/- mice, as shown by decreased serum amylase and lipase, as well as histological damage. CP mice surprisingly showed only slightly reduced fibrosis of the pancreas. Also staining of CD206 a classical marker of alternatively activated macrophages showed no decrease of M2-like polarization in the absence of STAT6. In contrast, transcription profile analysis in BMDM showed complete blockade of the IL4/IL13 pathway in STAT6-/- animals. Conclusion: STAT6 signaling pathway is protective during AP and mitigates the pancreatic damage. During chronic pancreatitis the IL4/IL13 – STAT6 axisis involved in organ fibrogenesis. Notably, fibrosis is not dependent on a single signaling pathway, and alternative macrophage activation is also complex and involves different subclasses (M2a, M2b, M2c and M2d) which could be independent of the IL4/IL13 STAT6 axis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=chronic%20pancreatitis" title="chronic pancreatitis">chronic pancreatitis</a>, <a href="https://publications.waset.org/abstracts/search?q=macrophages" title=" macrophages"> macrophages</a>, <a href="https://publications.waset.org/abstracts/search?q=IL4%2FIL13" title=" IL4/IL13"> IL4/IL13</a>, <a href="https://publications.waset.org/abstracts/search?q=Type%20immune%20response" title=" Type immune response"> Type immune response</a> </p> <a href="https://publications.waset.org/abstracts/183291/il4il13-stat6-mediated-macrophage-polarization-during-acute-and-chronic-pancreatitis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/183291.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">67</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> The Type II Immune Response in Acute and Chronic Pancreatitis Mediated by STAT6 in Murine</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hager%20Elsheikh">Hager Elsheikh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Context: Pancreatitis is a condition characterized by inflammation in the pancreas, which can lead to serious complications if untreated. Both acute and chronic pancreatitis are associated with immune reactions and fibrosis, which further damage the pancreas. The type 2 immune response, primarily driven by alternative activated macrophages (AAMs), plays a significant role in the development of fibrosis. The IL-4/STAT6 pathway is a crucial signaling pathway for the activation of M2 macrophages. Pancreatic fibrosis is induced by dysregulated inflammatory responses and can result in the autodigestion and necrosis of pancreatic acinar cells. Research Aim: The aim of this study is to investigate the impact of STAT6, a crucial molecule in the IL-4/STAT6 pathway, on the severity and development of fibrosis during acute and chronic pancreatitis. The research also aims to understand the influence of the JAK/STAT6 signaling pathway on the balance between fibrosis and regeneration in the presence of different macrophage populations. Methodology: The research utilizes murine models of acute and chronic pancreatitis induced by cerulean injection. Animal models will be employed to study the effect of STAT6 knockout on disease severity and fibrosis. Isolation of acinar cells and cell culture techniques will be used to assess the impact of different macrophage populations on wound healing and regeneration. Various techniques such as PCR, histology, immunofluorescence, and transcriptomics will be employed to analyze the tissues and cells. Findings: The research aims to provide insights into the mechanisms underlying tissue fibrosis and wound healing during acute and chronic pancreatitis. By investigating the influence of the JAK/STAT6 signaling pathway and different macrophage populations, the study aims to understand their impact on tissue fibrosis, disease severity, and pancreatic regeneration. Theoretical Importance: This research contributes to our understanding of the role of specific signaling pathways, macrophage polarization, and the type 2 immune response in pancreatitis. It provides insights into the molecular mechanisms underlying tissue fibrosis and the potential for targeted therapies. Data Collection and Analysis Procedures: Data will be collected through the use of murine models, isolation and culture of acinar cells, and various experimental techniques such as PCR, histology, immunofluorescence, and transcriptomics. Data will be analyzed using appropriate statistical methods and techniques, and the findings will be interpreted in the context of the research objectives. Conclusion: By investigating the mechanisms of tissue fibrosis and wound healing during acute and chronic pancreatitis, this research aims to enhance our understanding of the disease progression and potential therapeutic targets. The findings have theoretical importance in expanding our knowledge of pancreatic fibrosis and the role of macrophage polarization in the context of the type 2 immune response. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=immunity%20in%20chronic%20diseases" title="immunity in chronic diseases">immunity in chronic diseases</a>, <a href="https://publications.waset.org/abstracts/search?q=pancreatitis" title=" pancreatitis"> pancreatitis</a>, <a href="https://publications.waset.org/abstracts/search?q=macrophages" title=" macrophages"> macrophages</a>, <a href="https://publications.waset.org/abstracts/search?q=immune%20response" title=" immune response"> immune response</a> </p> <a href="https://publications.waset.org/abstracts/186332/the-type-ii-immune-response-in-acute-and-chronic-pancreatitis-mediated-by-stat6-in-murine" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/186332.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">34</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Account <li><a href="https://waset.org/profile">My Account</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Explore <li><a href="https://waset.org/disciplines">Disciplines</a></li> <li><a href="https://waset.org/conferences">Conferences</a></li> <li><a href="https://waset.org/conference-programs">Conference Program</a></li> <li><a href="https://waset.org/committees">Committees</a></li> <li><a href="https://publications.waset.org">Publications</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Research <li><a href="https://publications.waset.org/abstracts">Abstracts</a></li> <li><a href="https://publications.waset.org">Periodicals</a></li> <li><a href="https://publications.waset.org/archive">Archive</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Open Science <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Philosophy.pdf">Open Science Philosophy</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Award.pdf">Open Science Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Society-Open-Science-and-Open-Innovation.pdf">Open Innovation</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Postdoctoral-Fellowship-Award.pdf">Postdoctoral Fellowship Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Scholarly-Research-Review.pdf">Scholarly Research Review</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Support <li><a href="https://waset.org/page/support">Support</a></li> <li><a href="https://waset.org/profile/messages/create">Contact Us</a></li> <li><a href="https://waset.org/profile/messages/create">Report Abuse</a></li> </ul> </div> </div> </div> </div> </div> <div class="container text-center"> <hr style="margin-top:0;margin-bottom:.3rem;"> <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" class="text-muted small">Creative Commons Attribution 4.0 International License</a> <div id="copy" class="mt-2">© 2024 World Academy of Science, Engineering and Technology</div> </div> </footer> <a href="javascript:" id="return-to-top"><i class="fas fa-arrow-up"></i></a> <div class="modal" id="modal-template"> <div class="modal-dialog"> <div class="modal-content"> <div class="row m-0 mt-1"> <div class="col-md-12"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"><span aria-hidden="true">×</span></button> </div> </div> <div class="modal-body"></div> </div> </div> </div> <script src="https://cdn.waset.org/static/plugins/jquery-3.3.1.min.js"></script> <script src="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/js/bootstrap.bundle.min.js"></script> <script src="https://cdn.waset.org/static/js/site.js?v=150220211556"></script> <script> jQuery(document).ready(function() { /*jQuery.get("https://publications.waset.org/xhr/user-menu", function (response) { jQuery('#mainNavMenu').append(response); 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