CINXE.COM

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class="page-template page-template-page-blank page-template-page-blank-php page page-id-1607 non-logged-in views-template-clinical-guidelines"> <div id="page" class="hfeed site"> <div id="content" class="site-content"> <div id="secondary" class="widget-area" role="complementary"> </div> <div id="primary" class="content-area"> <main id="main" class="site-main" role="main"> <article id="post-1607" class="post-1607 page type-page status-publish hentry"> <div class="entry-content"> <a href="/resources/health-professionals/clinical-guidance/" class="osteo-button">< Back to Resources for Health Professionals</a> <a href="http://www.goodfellowunit.org/podcast/osteoporosis-update-ian-reid" class="osteo-button">Listen to the podcast</a> <img loading="lazy" decoding="async" id="clinical-guidelines" src="https://osteoporosis.org.nz/wp-content/uploads/osteo-clinical-guidelines.png" border="0" width="800" height="1132" orgWidth="800" orgHeight="1132" usemap="#clinical-guidelines-map" alt="" /> <map name="clinical-guidelines-map"> <area alt="" data-reference="a" class="guide-reference" shape="rect" coords="160,160,173,173" style="outline:none;" target="_self" /> <area alt="" data-reference="b" class="guide-reference" shape="rect" coords="478,159,489,172" style="outline:none;" target="_self" /> <area alt="" data-reference="c" class="guide-reference" shape="rect" coords="316,322,327,335" style="outline:none;" target="_self" /> <area alt="" data-reference="d" class="guide-reference" shape="rect" coords="304,388,315,400" style="outline:none;" target="_self" /> <area alt="" data-reference="e" class="guide-reference" shape="rect" coords="335,403,347,416" style="outline:none;" target="_self" /> <area alt="" data-reference="f" class="guide-reference" shape="rect" coords="679,413,694,429" style="outline:none;" target="_self" /> <area alt="" data-reference="g" class="guide-reference" shape="rect" coords="292,504,304,520" style="outline:none;" target="_self" /> <area alt="" 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style="outline:none;" target="_self" /> <area alt="" title="Falls risk assessment" href="#falls-risk" shape="rect" coords="72,306,441,325" style="outline:none;" target="_self" /> <area alt="" title="Vitamin D" href="#vit-d" shape="rect" coords="72,324,335,338" style="outline:none;" target="_self" /> <area alt="" title="Clinicial risk assessment" href="#clinical-risk" shape="rect" coords="25,354,204,378" style="outline:none;" target="_self" /> <area alt="" title="BMD assessment" href="#bmd" shape="rect" coords="66,385,355,403" style="outline:none;" target="_self" /> <area alt="" title="Fracture risk assessment" href="#fracture-risk" shape="rect" coords="70,405,355,420" style="outline:none;" target="_self" /> <area alt="" title="Secondary osteoporosis" href="#secondary-osteo" shape="rect" coords="538,383,748,441" style="outline:none;" target="_self" /> <area alt="" title="Risk stratification 1" href="#risk-strat" shape="rect" coords="25,451,162,473" style="outline:none;" target="_self" /> <area alt="" title="Risk stratification" href="#risk-strat" shape="rect" coords="196,481,435,527" style="outline:none;" target="_self" /> <area alt="" title="First line therapy" href="#first-line" shape="rect" coords="29,590,163,609" style="outline:none;" target="_self" /> <area alt="" title="Oral bisphosphonate" href="#oral" shape="rect" coords="265,603,405,637" style="outline:none;" target="_self" /> <area alt="" title="IV Zoledronate" href="#iv" shape="rect" coords="528,605,664,638" style="outline:none;" target="_self" /> <area alt="" title="Monitoring" href="#monitoring" shape="rect" coords="27,647,118,670" style="outline:none;" target="_self" /> <area alt="" title="PINP measurement" href="#pinp" shape="rect" coords="216,667,386,710" style="outline:none;" target="_self" /> <area alt="" title="Repeat DXA" href="#repeat-dxa" shape="rect" coords="420,808,572,834" style="outline:none;" target="_self" /> <area alt="" title="Duration and drug holiday" href="#duration" shape="rect" coords="415,856,580,900" style="outline:none;" target="_self" /> <area alt="" title="Teriparatide" href="#teripara" shape="rect" coords="328,1038,548,1076" style="outline:none;" target="_self" /> </map> <div id="graphic-details"> <p><img fetchpriority="high" decoding="async" class="size-full wp-image-1910 alignleft" src="https://osteoporosis.org.nz/wp-content/uploads/osteo-clinical-guidelines-1.png" alt="" width="800" height="1132" srcset="https://osteoporosis.org.nz/wp-content/uploads/osteo-clinical-guidelines-1.png 800w, https://osteoporosis.org.nz/wp-content/uploads/osteo-clinical-guidelines-1-212x300.png 212w, https://osteoporosis.org.nz/wp-content/uploads/osteo-clinical-guidelines-1-724x1024.png 724w, https://osteoporosis.org.nz/wp-content/uploads/osteo-clinical-guidelines-1-768x1087.png 768w" sizes="(max-width: 800px) 100vw, 800px" /></p> <div id="wpv-view-layout-1632" class="js-wpv-view-layout js-wpv-layout-responsive js-wpv-view-layout-1632" data-viewnumber="1632" data-pagination="{"id":"1632","query":"normal","type":"disabled","effect":"fade","duration":500,"speed":5,"pause_on_hover":"disabled","stop_rollover":"false","cache_pages":"enabled","preload_images":"enabled","preload_pages":"enabled","preload_reach":1,"spinner":"builtin","spinner_image":"https://osteoporosisnz.wpengine.com/wp-content/plugins/wp-views/res/img/ajax-loader.gif","callback_next":"","manage_history":"enabled","has_controls_in_form":"disabled","infinite_tolerance":"0","max_pages":0,"page":1,"base_permalink":"/clinical-guidance/?wpv_view_count=1632&wpv_paged=WPV_PAGE_NUM","loop":{"type":"","name":"","data":[],"id":0}}" data-permalink="/clinical-guidance/?wpv_view_count=1632"> <div id="tooltip-a" class="reference-tooltip"> <p><strong><span style="color: #932923;">a</span> Risk factors:</strong></p> <ul> <li>Age ≥65 years (women); ≥75 years (men)</li> <li>BMI <20 kg/m<sup>2</sup></li> <li>Family history of osteoporosis</li> <li>Smoking (current)</li> <li>Glucocorticoid use (current)</li> <li>Early menopause</li> <li>>2 alcoholic drinks daily</li> <li>History of falls</li> <li>Rheumatoid arthritis</li> <li>History of eating disorders</li> </ul> </div> <div id="tooltip-b" class="reference-tooltip"> <p><strong><span style="color: #932923 !important;">b</span></strong> The most common <strong>osteoporotic fractures</strong> are those of the vertebrae, proximal femur, distal forearm, humerus and pelvis; however, any recent fracture at a major skeletal site in older adults should prompt further assessment for osteoporosis. Exceptions are fractures of the digits, face and skull.</p> </div> <div id="tooltip-c" class="reference-tooltip"> <p><strong><span style="color: #932923;">c</span></strong> Individuals at risk of <strong>vitamin D deficiency</strong> will include the frail/institutionalised elderly, veiled women and those with dark skin living at higher latitudes.</p> </div> <div id="tooltip-d" class="reference-tooltip"> <p><strong><span style="color: #932923;">d</span></strong> Although <strong>DXA</strong> is recommended after fracture, treatment must <strong>not</strong> be delayed if DXA is unavailable.</p> </div> <div id="tooltip-e" class="reference-tooltip"> <p><strong><span style="color: #932923;">e</span> FRAX<sup>®</sup></strong> or <strong>Garvan </strong>fracture risk can be calculated without BMD if DXA is not available.</p> </div> <div id="tooltip-f" class="reference-tooltip"> <p><strong><span style="color: #932923;">f</span></strong> Search for <strong>contributory factors </strong>as appropriate through a clinical history and examination and through measurement of relevant biomarkers.</p> </div> <div id="tooltip-g" class="reference-tooltip"> <p><strong><span style="color: #932923;">g</span></strong> A <strong>10-year hip fracture risk</strong> of ≥3% as the threshold for initiating treatment is indicative, based on pharmacoeconomic analyses. Individuals with a 10-year hip fracture risk of 3% have a 10-year major osteoporotic fracture risk of ~20% and a total fracture risk of ~40%.</p> </div> <div id="tooltip-h" class="reference-tooltip"> <p><strong><span style="color: #932923;">h</span></strong> As an alternative to bisphophonates, <strong>oestrogen therapy</strong> may be considered as first-line therapy for women within 10 years of menopause.</p> </div> <div id="tooltip-i" class="reference-tooltip"> <p><strong><span style="color: #932923;">i</span> Zoledronate</strong> is an <strong>IV bisphosphonate</strong> that <strong>reduces risk</strong> of hip, vertebral and non-vertebral fractures<span style="color: #00aced;"><strong><sup><a style="color: #00aced;" href="#ref-6">6</a></sup></strong></span>. In the pivotal clinical trials, zoledronate was administered annually for three years. However, zoledronate’s duration of action is <strong>considerably longer</strong> than one year; therefore, it is common practice to administer the three initial doses at intervals of 18 or 24 months.</p> </div> <div id="tooltip-j" class="reference-tooltip"> <p><strong><span style="color: #932923;">j</span> </strong>There is limited evidence to guide <strong>treatment beyond 10 years.</strong> Individuals with a persistently increased fracture risk should be considered for long-term intervention, with <strong>drug holidays</strong> every few years. Guidance from a secondary care colleague should be considered.</p> </div> </div> <h2 class="graphic-anchor">Key Notes</h2> <div id="wpv-view-layout-1633" class="js-wpv-view-layout js-wpv-layout-responsive js-wpv-view-layout-1633" data-viewnumber="1633" data-pagination="{"id":"1633","query":"normal","type":"disabled","effect":"fade","duration":500,"speed":5,"pause_on_hover":"disabled","stop_rollover":"false","cache_pages":"enabled","preload_images":"enabled","preload_pages":"enabled","preload_reach":1,"spinner":"builtin","spinner_image":"https://osteoporosisnz.wpengine.com/wp-content/plugins/wp-views/res/img/ajax-loader.gif","callback_next":"","manage_history":"enabled","has_controls_in_form":"disabled","infinite_tolerance":"0","max_pages":0,"page":1,"base_permalink":"/clinical-guidance/?wpv_view_count=1633&wpv_paged=WPV_PAGE_NUM","loop":{"type":"","name":"","data":[],"id":0}}" data-permalink="/clinical-guidance/?wpv_view_count=1633"> <div id="tooltip-list"> <p><strong><span style="color: #932923;">a</span> Risk factors:</strong></p> <ul> <li>Age ≥65 years (women); ≥75 years (men)</li> <li>BMI <20 kg/m<sup>2</sup></li> <li>Family history of osteoporosis</li> <li>Smoking (current)</li> <li>Glucocorticoid use (current)</li> <li>Early menopause</li> <li>>2 alcoholic drinks daily</li> <li>History of falls</li> <li>Rheumatoid arthritis</li> <li>History of eating disorders</li> </ul> <p><strong><span style="color: #932923 !important;">b</span></strong> The most common <strong>osteoporotic fractures</strong> are those of the vertebrae, proximal femur, distal forearm, humerus and pelvis; however, any recent fracture at a major skeletal site in older adults should prompt further assessment for osteoporosis. Exceptions are fractures of the digits, face and skull.</p> <p><strong><span style="color: #932923;">c</span></strong> Individuals at risk of <strong>vitamin D deficiency</strong> will include the frail/institutionalised elderly, veiled women and those with dark skin living at higher latitudes.</p> <p><strong><span style="color: #932923;">d</span></strong> Although <strong>DXA</strong> is recommended after fracture, treatment must <strong>not</strong> be delayed if DXA is unavailable.</p> <p><strong><span style="color: #932923;">e</span> FRAX<sup>®</sup></strong> or <strong>Garvan </strong>fracture risk can be calculated without BMD if DXA is not available.</p> <p><strong><span style="color: #932923;">f</span></strong> Search for <strong>contributory factors </strong>as appropriate through a clinical history and examination and through measurement of relevant biomarkers.</p> <p><strong><span style="color: #932923;">g</span></strong> A <strong>10-year hip fracture risk</strong> of ≥3% as the threshold for initiating treatment is indicative, based on pharmacoeconomic analyses. Individuals with a 10-year hip fracture risk of 3% have a 10-year major osteoporotic fracture risk of ~20% and a total fracture risk of ~40%.</p> <p><strong><span style="color: #932923;">h</span></strong> As an alternative to bisphophonates, <strong>oestrogen therapy</strong> may be considered as first-line therapy for women within 10 years of menopause.</p> <p><strong><span style="color: #932923;">i</span> Zoledronate</strong> is an <strong>IV bisphosphonate</strong> that <strong>reduces risk</strong> of hip, vertebral and non-vertebral fractures<span style="color: #00aced;"><strong><sup><a style="color: #00aced;" href="#ref-6">6</a></sup></strong></span>. In the pivotal clinical trials, zoledronate was administered annually for three years. However, zoledronate’s duration of action is <strong>considerably longer</strong> than one year; therefore, it is common practice to administer the three initial doses at intervals of 18 or 24 months.</p> <p><strong><span style="color: #932923;">j</span> </strong>There is limited evidence to guide <strong>treatment beyond 10 years.</strong> Individuals with a persistently increased fracture risk should be considered for long-term intervention, with <strong>drug holidays</strong> every few years. Guidance from a secondary care colleague should be considered.</p> </div> </div> <p> </p> <h2 id="presentation" class="graphic-anchor">Presentation</h2> <h3>Fracture Liaison Service (FLS)</h3> <p>The FLS systematically identifies individuals who have sustained a fragility fracture, with the intention of preventing subsequent fractures. Fragility fracture sufferers will be offered an assessment for future fracture risk including bone health (i.e. osteoporosis) and falls risk.</p> <p>The FLS works with the fragility fracture sufferer and their GP to develop a long-term plan aimed at reducing risk of falls and fractures, and promoting long-term management.</p> <p>In New Zealand, this service is provided by health professionals who are employed by District Health Boards or Primary Health Organisations. While respective FLS may have slight variations in target population, generally any individual with an age-related low impact (or non-traumatic) fracture involving the proximal femur, wrist, humerus, vertebrae or pelvis is considered appropriate for FLS assessment.</p> <p><a href="https://osteoporosis.org.nz/resources/health-professionals/clinical-standards-for-fls/" target="_blank" rel="noopener noreferrer">Clinical standards for FLS in New Zealand</a> are available that detail the evidence-based standards of post-fracture care that health professionals and patients should expect.</p> <p> </p> <h2 id="lifestyle-modification" class="graphic-anchor"><span style="color: #00aced;">Lifestyle modifications</span></h2> <h3 id="modifiable-risk" class="graphic-anchor">Modifiable risk factors</h3> <p>Modifiable risk factors include:</p> <ul> <li>Limiting alcohol to no more than two standard drinks per day, with at least two alcohol-free days per week</li> <li>Maintaining a body mass index 20–25 kg/m<sup>2</sup></li> <li>Stopping smoking</li> <li>Regular exercise, including ≥30 minutes of weight-bearing physical activity each day</li> </ul> <h3 id="falls-risk" class="graphic-anchor">Falls risk assessment and prevention programme <em>(Ask, Assess, Act)</em></h3> <p><a href="http://www.hqsc.govt.nz/assets/Falls/PR/AAA-pocket-card-read-Apr-2014.pdf" class="mtli_attachment mtli_pdf" class="mtli_attachment mtli_pdf" target="_blank" rel="noopener noreferrer">Ask, Assess, Act</a> is an initiative of the Health Quality and Safety Commission of New Zealand.</p> <p>It requires the health practitioner to:</p> <ol> <li><strong><span style="color: #00aced !important;">ASK</span> the person three simple screening questions</strong>: <ol> <li>Have you slipped, tripped or fallen in the last year?</li> <li>Can you get out of a chair without using your hands?</li> <li>Have you avoided some activities because you are afraid you might lose your balance?</li> </ol> </li> <li><strong><span style="color: #00aced !important;">ASSESS</span> the person to identify their particular falls risk</strong></li> <li><strong><span style="color: #00aced !important;">ACT</span> by putting individualised intervention and supports in place</strong></li> </ol> <p><a href="http://www.acc.co.nz/preventing-injuries/falls/older-people/information-for-health-professionals/index.htm" target="_blank" rel="noopener noreferrer">A falls prevention programme</a> may include education on the risk of falling, medication review, evidence-based exercise programmes*, use of appropriate assistive devices, treatment of postural hypotension and cardiovascular disorders, reduction of environmental hazards, eyesight examinations and correction of vitamin D deficiency.</p> <p>* <em><sub>There is evidence that completion of structured programs with progressive lower-limb strengthening and balance exercises can reduce falls rates by up to 30%</sub></em></p> <h3 id="vit-d" class="graphic-anchor">Vitamin D supplementation</h3> <p>Vitamin D is mainly important for the prevention of osteomalacia; treatment of mild vitamin D deficiency does not seem to confer significant benefits in terms of bone mineral density (BMD)<span style="color: #00aced;"><strong><sup><a href="#ref-1">1</a></sup></strong></span> or fracture risk.<span style="color: #00aced;"><strong><sup><a href="#ref-2">2</a></sup></strong></span></p> <p>The best source of vitamin D is sunlight. For most people, vitamin D deficiency can be prevented by 5 to 10 minutes’ exposure of face, arms and hands to sunlight 4 to 6 times per week. In New Zealand, exposure should be restricted at high UV times.<span style="color: #00aced;"><strong><sup><a href="#ref-3">3</a></sup></strong></span></p> <p>Most healthy European New Zealand adults living independently do not require vitamin D supplements. Individuals at risk of vitamin D deficiency include the frail/institutionalised elderly, veiled women and those with dark skin living at higher latitudes. If vitamin D supplementation is required, doses of 400–800 IU/day or 1.25 mg/month are usually sufficient.</p> <h3>Calcium supplementation</h3> <p>Calcium supplementation is no longer routinely recommended to improve bone health because it lacks fracture reduction efficacy and potentially increases cardiovascular events.<span style="color: #00aced;"><strong><sup><a href="#ref-4">4</a></sup></strong></span></p> <p>A dietary calcium intake of 500 mg/day (2–3 servings of calcium-rich foods such as dairy products [milk, yoghurt, cheese], calcium-fortified products [fortified soy and rice milks, fortified cereals and fortified orange juice], tofu, calcium-rich vegetables, tinned sardines/salmon [including the bones] or calcium-rich nuts and fruits) is sufficient for an adult.</p> <p> </p> <h2 id="clinical-risk" class="graphic-anchor"><span style="color: #00aced;">Clinical Risk Assessment</span></h2> <h3 id="bmd" class="graphic-anchor">Bone mineral density (BMD) assessment</h3> <p>BMD is one predictor of fracture risk and should be measured using dual energy x-ray absorptiometry (DXA) performed at two sites, preferably anteroposterior spine and hip. With advancing age, degenerative changes in the spine may result in falsely elevated BMD levels at that site; therefore, DXA of the hip is more reliable.</p> <p>BMD results are reported as a T-score (number of standard deviations that BMD is above or below the mean of healthy young adults) or a Z-score (number of standard deviations that BMD is above or below the mean of normal controls matched for age).</p> <p>The World Health Organization defines osteoporosis as a T-score ≤-2.5 and osteopenia as a T-score between -1 and -2.5.</p> <p>BMD should be assessed in individuals with suspicion of osteoporosis to establish a baseline reading that can be used to inform future management. Indications for BMD assessment include:</p> <ul> <li><strong>Minimal trauma fracture</strong></li> <li><strong>Women aged <65 years with risk factors for osteoporosis</strong></li> <li><strong>Women aged ≥65 years and men aged ≥75 years considering specific measures to prevent osteoporosis</strong></li> <li><strong>All users of glucocorticoids for >6 months</strong></li> </ul> <p>However, fracture risk assessment and anti-osteoporotic treatment must not be withheld if DXA scanning is unavailable. It is acceptable to assess fracture risk with FRAX<sup>®</sup>/Garvan calculators without a BMD value if DXA is unavailable. Patients aged ≥75 years with a significant osteoporotic fracture demonstrated radiologically do not necessarily require a BMD assessment for PHARMAC medication access. Refer – First-line Therapy section of this document.</p> <p>Note that Accident Compensation Corporation (ACC) can fund DXA scans in relation to an accepted ACC claim for a fragility fracture and if the referral has been made by a vocationally-registered specialist. The request is subject to approval and must meet the following criteria:</p> <ol> <li><strong>There is an accepted ACC claim for a fracture AND</strong></li> <li><strong>The fracture is likely to be a fragility fracture (fracture resulting from a fall from standing height or less) AND</strong></li> <li><strong>The person is <75 years old and considered to be at reasonable risk of further fractures OR is between 50–75 years old and is receiving systemic glucocorticoid therapy (≥ 5 mg/day prednisone equivalent) for ≥3 months AND</strong></li> <li><strong>The person has not had a DXA scan previously and is not known to be on bisphosphonates or other osteoporosis medication AND</strong></li> <li><strong>The request for DXA must be part of an assessment in a comprehensive and integrated pathway to minimise harm from falls and fractures.</strong></li> </ol> <h3 id="fracture-risk" class="graphic-anchor">Fracture risk assessment</h3> <p>Absolute fracture risk is usually the basis of therapeutic shared decision making. This can be calculated using the <a href="http://www.shef.ac.uk/FRAX/tool.aspx?country=23" target="_blank" rel="noopener noreferrer">Fracture Risk Assessment (FRAX<sup>®</sup>) tool</a> or <a href="http://www.garvan.org.au/promotions/bone-fracture-risk/calculator">Garvan Fracture Risk Calculator</a>. FRAX<sup>®</sup> and Garvan calculators include BMD as a risk factor; however, risk can be calculated in the absence of a BMD measurement.</p> <p>Hip fracture risk calculated by FRAX<sup>®</sup> doubles every 5 to 6 years in postmenopausal women. This should be the basis for determining the time to follow-up BMD measurement in those not requiring intervention at the time of the present assessment. For example, if current hip fracture risk is 0.5%, reassessment is not likely to lead to a management change for approximately 15 years, whereas higher baseline fracture risk justifies earlier re-measurement.</p> <h3 id="secondary-osteo" class="graphic-anchor">Secondary osteoporosis</h3> <p>Secondary causes of osteoporosis should be investigated in individuals with low BMD for age (i.e. a Z-score <-2).</p> <p>The following conditions have been associated with increased risk of osteoporosis:</p> <ul> <li><strong>Low body weight from any cause (including a past or current eating disorder)</strong></li> <li><strong>Chronic inflammatory disease (e.g. inflammatory bowel disease, rheumatoid arthritis, chronic obstructive pulmonary disease, inflammatory connective tissue disease/arthropathy, coeliac disease)</strong></li> <li><strong>Iatrogenic glucocorticoid excess or Cushing’s disease</strong></li> <li><strong>Hypogonadism or premature menopause (<45 years)</strong></li> <li><strong>Excess alcohol use or smoking</strong></li> </ul> <p>Other conditions associated with low BMD include: type 1 diabetes mellitus, osteogenesis imperfecta in adults, untreated longstanding hyperthyroidism, hyperparathyroidism, chronic malnutrition or malabsorption, bariatric surgery and chronic liver disease.</p> <p>Drug classes associated with major bone loss include glucocorticoids<span style="color: #00aced;"><strong><sup><a href="#ref-5">5</a></sup></strong></span> and androgen deprivation therapy. Some bone loss has been reported with use of injectable medroxyprogesterone acetate and aromatase inhibitors.</p> <p>Search for contributory factors as appropriate through a clinical history and examination and through measurement of:</p> <ul> <li><strong>Serum calcium</strong></li> <li><strong>Serum phosphate</strong></li> <li><strong>Alkaline phosphatase</strong></li> <li><strong>Cortisol</strong></li> <li><strong>Thyroid-stimulating hormone</strong></li> <li><strong>Coeliac screen</strong></li> <li><strong>Liver and renal function tests</strong></li> <li><strong>Protein electrophoresis</strong></li> <li><strong>Full blood count</strong></li> <li><strong>C-reactive protein</strong></li> </ul> <p>In men aged <75 years with a Z-score <-2 and fractures, consider evaluating testosterone levels.</p> <p>Note that a detailed screen for secondary causes of osteoporosis is not indicated in individuals with a BMD in the appropriate range for age (i.e. a Z-score ≥-2).</p> <p> </p> <h2 id="risk-strat" class="graphic-anchor"><span style="color: #00aced;">Treatment</span></h2> <p>Patients with any of the following characteristics should be offered treatment:</p> <ul> <li><strong>10-year FRAX<sup>®</sup>/Garvan hip fracture risk of ≥3%</strong></li> <li><strong>T-score ≤-2.5 (or ≤-1.5 for individuals on long-term glucocorticoid therapy)</strong></li> </ul> <p> </p> <h2 id="first-line" class="graphic-anchor"><span style="color: #00aced;">First-line Therapy</span></h2> <h3 id="oral" class="graphic-anchor">Oral bisphosphonates</h3> <p><a href="http://www.pharmac.govt.nz/Schedule?osq=alendronate" target="_blank" rel="noopener noreferrer">Alendronate</a> and risedronate are oral bisphosphonates shown to reduce the risk of hip, vertebral and non-vertebral fractures.<span style="color: #00aced;"><strong><sup><a href="#ref-6">6</a></sup></strong></span> Risedronate is available for general prescription in New Zealand without Special Authority approval.</p> <p>Contraindications to oral bisphosphonates include: abnormalities of the oesophagus that delay oesophageal emptying such as stricture or achalasia; inability to stand/sit upright for ≥30 minutes; and hypocalcaemia.</p> <p>The most common side effect of oral bisphosphonates is upper gastrointestinal irritation, which affects 20–30% of users. Patients should be advised to take their oral bisphosphonate on an empty stomach. They should swallow their oral bisphosphonate tablet with a full glass of water and stand/sit upright for ≥30 minutes and until after their first food of the day.</p> <p>There is scant clinical evidence regarding use of oral bisphosphonates in patients with severe renal insufficiency. Consider a reduced dosing frequency in patients with estimated glomerular filtration rate (eGFR) ≤35 mL/min.</p> <p>Atypical femoral fractures (AFFs) initially develop as stress fractures in the lateral cortex of the femoral shaft and can spontaneously progress to transverse fractures. The incidence of AFFs appears to increase steeply with duration of bisphosphonate use and drops dramatically in the 1–2 years after bisphosphonate discontinuation. For this reason, it is important to periodically review the need for continued bisphosphonate therapy and provide drug holidays for patients requiring therapy for >5 years.</p> <p>Osteonecrosis of the jaw (ONJ) manifests as an area of exposed bone in the mouth that does not heal within 8 weeks. While ONJ has been associated with bisphosphonate use for the treatment of bone metastases, it is rarely seen in patients treated with oral or IV bisphosphonates for osteoporosis and appears to have an incidence similar to that found in patients with osteoporosis not treated with bisphosphonates.</p> <h3 id="iv" class="graphic-anchor">Intravenous bisphosphonate</h3> <p><a href="http://www.pharmac.govt.nz/Schedule?osq=zoledronic%20acid" target="_blank" rel="noopener noreferrer">Zoledronate</a> is an IV bisphosphonate that reduces risk of hip, vertebral and non-vertebral fractures.<span style="color: #00aced;"><strong><sup><a href="#ref-6">6</a></sup></strong></span> In the pivotal clinical trials, zoledronate was administered annually for three years. However, zoledronate’s duration of action is considerably longer than one year; therefore, it is common practice to administer the three initial doses at intervals of 18 or 24 months.</p> <p>Contraindications to zoledronate include: creatinine clearance or eGFR <35 mL/min; marked vitamin D deficiency; and hypocalcaemia.</p> <p>The most common side effect of zoledronate is post-dose flu-like symptoms (affecting approximately 30% of patients), the majority of which occur within the first 3 days following zoledronate administration and resolve within 3 days. The incidence of these symptoms can be reduced with administration of paracetamol or ibuprofen shortly after the zoledronate dose. These symptoms decrease markedly with subsequent doses of zoledronate (incidence of 1–2%). Ensure adequate hydration.</p> <p>Vitamin D deficiency should be corrected before the administration of zoledronate. In patients with suspicion of vitamin D deficiency, give oral supplementation (2 x cholecalciferol 50,000 IU) before infusion.</p> <p>Consider a dose reduction (e.g. to 2.5 or 1 mg<span style="color: #00aced;"><strong><sup><a href="#ref-7">7</a></sup></strong></span>) or slower infusion rate (e.g. to 30 to 60 mins) in patients with eGFR 35–50 mL/min.</p> <h3>Oestrogen therapy</h3> <p>In women with osteoporosis and within 10 years of menopause, oestrogen therapy may be an appropriate first-line intervention. Risks and benefits of therapy should be explored with the patient. Referral to a secondary care colleague may be helpful to help frame a long-term plan for the patient’s osteoporosis management.</p> <p>Contraindications to oestrogen therapy include: past or acute myocardial infarction or stroke, breast cancer or sex steroid hormone responsive tumours, liver tumours, past venous thromoembotic events (or a hereditary or acquired predisposition to venous thrombosis) and severe hepatic disease.</p> <p>Common side effects of oestrogen therapy include: vaginal bleeding, fluid retention, breast tenderness, headaches and nausea.</p> <p> </p> <h2 id="monitoring" class="graphic-anchor"><span style="color: #00aced;">Monitoring</span></h2> <h3 id="pinp" class="graphic-anchor">Serum procollagen type I N-terminal propeptide (PINP) measurement</h3> <p>Bisphosphonates reduce bone turnover, which can be assessed by measuring serum PINP. With effective bisphosphonate therapy, PINP levels will decrease to <35 μg/L.</p> <p>If PINP levels remain ≥35 μg/L after 6 months of oral bisphosphonate treatment, this indicates suboptimal adherence to the bisphosphonate or poor absorption of the bisphosphonate.<span style="color: #00aced;"><strong><sup><a href="#ref-8">8</a></sup></strong></span> Switching to an IV bisphosphonate should be considered.</p> <p>PINP measurement can be organised through the local laboratory, with no time-of-day restrictions for obtaining blood samples.</p> <p>PINP levels do not usually need to be assessed in patients treated with IV bisphosphonate.</p> <h3 id="repeat-dxa" class="graphic-anchor">Repeat clinical risk assessment</h3> <p>Follow-up bone densitometry is not recommended at intervals of less than 3 years in most patients. In addition to reproducibility errors in results, a repeat scan in the first few years of therapy will not generally alter management. Repeat BMD assessment should be undertaken 4 to 5 years after initiating bisphosphonate treatment to determine whether treatment should continue.</p> <h3 id="duration" class="graphic-anchor">Duration of treatment and drug holidays</h3> <p>Clinical trials have shown that after 3 to 5 years of bisphosphonate therapy, patients whose femoral T-score has risen above -2.5 and who have not had new fractures are able to discontinue bisphosphonate treatment for up to 5 years without an increase in their future fracture risk. Therefore, remaining off treatment for 4 to 5 years is appropriate for patients meeting these criteria.</p> <p>Patients with a femoral T-score ≤-2.5 or with new/recurrent fractures should continue on treatment for a second 5-year period. However, there is concern that continuous, long-term bisphosphonate therapy progressively increases the risk of atypical femoral fractures, potentially neutralizing the benefit of ongoing treatment. To address this concern, many clinicians recommend a 1- to 2-year drug holiday at some time between years 5 and 10. Risedronate has a shorter duration of action than other bisphosphonates, so a 1-year break is likely appropriate for that medication.<span style="color: #00aced;"><strong><sup><a href="#ref-9">9</a>,<a href="#ref-10">10</a></sup></strong></span></p> <p><span style="color: #00aced;"><em>RNZCGP believes that use of PINP in monitoring osteoporosis treatment is not yet proven in clinical practice.</em></span></p> <h2 id="teripara" class="graphic-anchor"><span style="color: #00aced;">Second-line Therapy</span></h2> <h3>Teriparatide</h3> <p><a href="http://www.pharmac.govt.nz/Schedule?osq=teriparatide" target="_blank" rel="noopener noreferrer">Teriparatide</a> is a fragment of parathyroid hormone, administered by once-daily subcutaneous injection, that may be used in patients with established osteoporosis and recurrent fracture and following at least 12 months of antiresorptive therapy.</p> <h3>Denosumab</h3> <p>Denosumab is a monoclonal antibody directed against RANK-ligand, administered by subcutaneous injection every 6 months, for treatment of osteoporosis. Denosumab is not yet reimbursed in New Zealand.</p> <h3>Other treatments:</h3> <p><strong>Selective estrogen receptor modulators (SERMS)<br /> </strong>SERMS (e.g. raloxifene) could be considered as an alternative to oestrogen therapy in postmenopausal women, although raloxifene does not prevent hip or other non-vertebral fractures.</p> <p><strong>Strontium ranelate<br /> </strong>Strontium ranelate is not recommended because of its adverse cardiovascular profile.</p> <p> </p> <h2><span style="color: #00aced;">References</span></h2> <p><span id="ref-1" class="graphic-anchor"><strong>1.</strong></span> Reid IR, Bolland MJ, Grey A. Effects of vitamin D supplements on bone mineral density: a systematic review and meta-analysis. Lancet 2014;383:146–55.</p> <p><span id="ref-2" class="graphic-anchor"><strong>2.</strong></span> Avenell A, Mak JC, O’Connell D. Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men. Cochrane Database Syst Rev 2014 Apr 14;4:CD000227.</p> <p><span id="ref-3" class="graphic-anchor"><strong>3.</strong></span> Nowson CA, McGrath JJ, Ebling PR, Haikerwai A, Daly RM, Sanders KM, Seibel MJ, Mason RS. Vitamin D and health in adults in Australia and New Zealand: a position statement. Med J Aust 2012;196:686–7.</p> <p><span id="ref-4" class="graphic-anchor"><strong>4.</strong></span> Reid IR. Efficacy, effectiveness and side effects of medications used to prevent fractures. J Intern Med 2015;277:690–706.</p> <p><span id="ref-5" class="graphic-anchor"><strong>5.</strong></span> Saag KG. Bone safety of low-dose glucocorticoids in rheumatic diseases. Ann NY Acad Sci 2014;1318:55–64.</p> <p><span id="ref-6" class="graphic-anchor"><strong>6.</strong></span> Murad MH, Drake MT, Mullan RJ, Mauck KF, Stuart LM, Lane MA, Abu Elnour NO, Erwin PJ, Hazem A, Puhan MA, Li T, Montori VM. Clinical review. Comparative effectiveness of drug treatments to prevent fragility fractures: a systematic review and network meta-analysis. J Clin Endocrinol Metab 2012;97:1871–8.</p> <p><span id="ref-7" class="graphic-anchor"><strong>7.</strong></span> Miller PD, Jamal SA, Evenepoel P, Eastell R, Boonen S. Renal safety in patients treated with bisphosphonates for osteoporosis: a review. J Bone Miner Res 2013;28:2049–59.</p> <p><span id="ref-8" class="graphic-anchor"><strong>8.</strong></span> Vasikaran S, Eastell R, Bruyere O, Foldes AJ, Garnero P, Griesmacher A, McClung M, Morris HA, Silverman S, Trenti T, Wahl DA, Cooper C, Kanis JA; IOF-IFCC Bone Marker Standards Working Group. Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards. Osteoporos Int 2011;22:391–420.</p> <p><span id="ref-9" class="graphic-anchor"><strong>9.</strong></span> Adler RA, El-Hajj Fuleihan G, Bauer DC, Camacho PM, Clarke BL, Clines GA, Compston JE, Drake MT, Edwards BJ, Favus MJ, Greenspan SL, McKinney R Jr, Pignolo RJ, Sellmeyer DE. Managing osteoporosis in patients on long-term bisphosphonate treatment: Report of a Task Force of the American Society for Bone and Mineral Research. J Bone Miner Res 2016;31:16–35.</p> <p><span id="ref-10" class="graphic-anchor"><strong>10.</strong></span> Eastell R, Hannon RA, Wenderoth D, Rodriguez-Moreno J, Sawicki A. Effect of stopping risedronate after long-term treatment on bone turnover. J Clin Endocrinol Metab 2011;96:3367–73.</p> <p> </p> <h2><span style="color: #00aced;">Development of the Guidance</span></h2> <p>The primary objective for the development of Diagnosis and Management of Osteoporosis for New Zealand was to provide clinicians working in both primary and secondary care settings with a user-friendly and highly practical tool to support evidence-based practice. The guidance provides a distillation of the current evidence base and makes practical recommendations on identification of high-risk individuals, diagnostics and treatment for both patients with fragility fractures and those at high-risk of suffering their first fragility fracture.</p> <p>The guidance development process has been funded by ACC. The criteria for development was outlined in an agreement between ACC and Osteoporosis New Zealand.</p> <p>To expedite the development process, the following Expert Panel from disciplines central to the management of osteoporosis were invited to join the group. Dr Nigel Gilchrist accepted the position of Chair.</p> <table> <tbody> <tr> <th>Name</th> <th>Title</th> </tr> <tr> <td><strong>Dr Nigel Gilchrist</strong></td> <td>Specialist Consultant Physician</td> </tr> <tr> <td><strong>Prof Ian Reid</strong></td> <td>Distinguished Professor of Medicine</td> </tr> <tr> <td><strong>Dr Shankar Sankaran</strong></td> <td>Consultant Geriatrician</td> </tr> <tr> <td><strong>Dr David Kim</strong></td> <td>Consultant Endocrinologist</td> </tr> <tr> <td><strong>Dr Alison Drewry</strong></td> <td>Senior Medical Advisor, ACC</td> </tr> <tr> <td><strong>Prof Les Toop</strong></td> <td>Professor and Head of Department of General Practice</td> </tr> <tr> <td><strong>Dr Frances McClure</strong></td> <td>General Practitioner</td> </tr> </tbody> </table> <p>Osteoporosis New Zealand provided project management support to assist the Expert Panel wherever possible to develop this guidance.</p> <p>Medical writer, Juliette Allport of Syntax Scientific Writing Ltd provided excellent freelance medical writing.</p> <p><span style="color: #00aced;"><em>This Guidance will be reviewed in 2020 unless new therapeutic options become available prior to that date. </em></span></p> <p> </p> <h2><span style="color: #00aced;">Endorsing organisations</span></h2> <p>The following learned societies and organisations endorse the Guidance on the Diagnosis and Management of Osteoporosis in New Zealand.</p> <table style="border: none;" width="100%"> <tbody> <tr style="border: none;"> <td style="border: none; padding: 15px;"> <img loading="lazy" decoding="async" class="aligncenter size-full wp-image-1706" src="https://osteoporosis.org.nz/wp-content/uploads/acc.png" alt="" width="175" height="153" /></td> <td style="border: none; padding: 15px;"> <img loading="lazy" decoding="async" class="aligncenter size-full wp-image-1707" src="https://osteoporosis.org.nz/wp-content/uploads/anzona.png" alt="" width="227" height="95" /></td> </tr> <tr style="border: none;"> <td style="border: none; padding: 15px;"> <img loading="lazy" decoding="async" class="aligncenter size-full wp-image-1708" src="https://osteoporosis.org.nz/wp-content/uploads/anzsgm.png" alt="" width="264" height="142" /></td> <td style="border: none; padding: 15px;"> <img loading="lazy" decoding="async" class="aligncenter size-full wp-image-1709" src="https://osteoporosis.org.nz/wp-content/uploads/ensa.png" alt="" width="295" height="115" /></td> </tr> <tr style="border: none;"> <td style="border: none; padding: 15px;"> <img loading="lazy" decoding="async" class="aligncenter size-full wp-image-1710" src="https://osteoporosis.org.nz/wp-content/uploads/flnnz.png" alt="" width="433" height="112" srcset="https://osteoporosis.org.nz/wp-content/uploads/flnnz.png 433w, https://osteoporosis.org.nz/wp-content/uploads/flnnz-300x78.png 300w" sizes="(max-width: 433px) 100vw, 433px" /></td> <td style="border: none; padding: 15px;"> <img loading="lazy" decoding="async" class="aligncenter size-full wp-image-1711" src="https://osteoporosis.org.nz/wp-content/uploads/hqscnz.png" alt="" width="386" height="114" srcset="https://osteoporosis.org.nz/wp-content/uploads/hqscnz.png 386w, https://osteoporosis.org.nz/wp-content/uploads/hqscnz-300x89.png 300w" sizes="(max-width: 386px) 100vw, 386px" /></td> </tr> <tr style="border: none;"> <td style="border: none; padding: 15px;"> <img loading="lazy" decoding="async" class="aligncenter size-full wp-image-1712" src="https://osteoporosis.org.nz/wp-content/uploads/nzamm.png" alt="" width="182" height="200" /></td> <td style="border: none; padding: 15px;"> <img loading="lazy" decoding="async" class="aligncenter size-full wp-image-1713" src="https://osteoporosis.org.nz/wp-content/uploads/nzoa.png" alt="" width="167" height="220" /></td> </tr> <tr style="border: none;"> <td style="border: none; padding: 15px;"> <img loading="lazy" decoding="async" class="aligncenter size-full wp-image-1714" src="https://osteoporosis.org.nz/wp-content/uploads/nzra.png" alt="" width="305" height="109" srcset="https://osteoporosis.org.nz/wp-content/uploads/nzra.png 305w, https://osteoporosis.org.nz/wp-content/uploads/nzra-300x107.png 300w" sizes="(max-width: 305px) 100vw, 305px" /></td> <td style="border: none; padding: 15px;"> <img loading="lazy" decoding="async" class="aligncenter size-full wp-image-1715" src="https://osteoporosis.org.nz/wp-content/uploads/nzsoe.png" alt="" width="308" height="90" srcset="https://osteoporosis.org.nz/wp-content/uploads/nzsoe.png 308w, https://osteoporosis.org.nz/wp-content/uploads/nzsoe-300x88.png 300w" sizes="(max-width: 308px) 100vw, 308px" /></td> </tr> <tr style="border: none;"> <td style="border: none; padding: 15px;"> <img loading="lazy" decoding="async" class="aligncenter size-full wp-image-1716" src="https://osteoporosis.org.nz/wp-content/uploads/pnz.png" alt="" width="267" height="150" /></td> <td style="border: none; padding: 15px;"> <img loading="lazy" decoding="async" class="aligncenter wp-image-1726 size-full" src="https://osteoporosis.org.nz/wp-content/uploads/racp_tagline.png" width="308" height="96" srcset="https://osteoporosis.org.nz/wp-content/uploads/racp_tagline.png 308w, https://osteoporosis.org.nz/wp-content/uploads/racp_tagline-300x94.png 300w" sizes="(max-width: 308px) 100vw, 308px" /></td> </tr> <tr style="border: none;"> <td style="border: none; 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