Effects of 尾-Glucan on the Release of Nitric Oxide by RAW264.7 Cells Stimulated with Escherichia coli Lipopolysaccharide

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Release of Nitric Oxide by RAW264.7 Cells Stimulated with Escherichia coli Lipopolysaccharide</title> <meta name="description" content="Effects of 尾-Glucan on the Release of Nitric Oxide by RAW264.7 Cells Stimulated with Escherichia coli Lipopolysaccharide"> <meta name="keywords" content="尾-glucan, lipopolysaccharide (LPS), nitric oxide (NO), RAW264.7 cells, STAT1"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a 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87358</div> </div> </div> </div> <div class="card publication-listing mt-3 mb-3"> <h5 class="card-header" style="font-size:.9rem">Effects of 尾-Glucan on the Release of Nitric Oxide by RAW264.7 Cells Stimulated with Escherichia coli Lipopolysaccharide</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Eun%20Young%20Choi">Eun Young Choi</a>, <a href="https://publications.waset.org/abstracts/search?q=So%20Hui%20Choe"> So Hui Choe</a>, <a href="https://publications.waset.org/abstracts/search?q=Jin%20Yi%20Hyeon"> Jin Yi Hyeon</a>, <a href="https://publications.waset.org/abstracts/search?q=Ji%20Young%20Jin"> Ji Young Jin</a>, <a href="https://publications.waset.org/abstracts/search?q=Bo%20Ram%20Keum"> Bo Ram Keum</a>, <a href="https://publications.waset.org/abstracts/search?q=Jong%20Min%20Lim"> Jong Min Lim</a>, <a href="https://publications.waset.org/abstracts/search?q=Hyung%20Rae%20Cho"> Hyung Rae Cho</a>, <a href="https://publications.waset.org/abstracts/search?q=Kwang%20Keun%20Cho"> Kwang Keun Cho</a>, <a href="https://publications.waset.org/abstracts/search?q=In%20Soon%20Choi"> In Soon Choi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This research analyzed the effect of 尾-glucan that is expected to alleviate the production of inflammatory mediator in macrophagocyte, which was processed by the lipopolysaccharide (LPS) of Escherichia, a pathogen related to allergy. The incubated layer was used for nitric oxide (NO) analysis. The DNA-binding activation of the small unit of NF-魏B was measured using ELISA-based kit. In RAW264.7 cells that were vitalized by E.coli LPS, 尾-glucan inhibited both the combatant and rendering phases of inducible NO synthase (iNOS)-derived NO. 尾-glucan increased the expression of heme oxygenase-1 (HO-1) in the cell that was stimulated by E.coli LPS, and HO-1 activation was inhibited by SnPP. This shows that NO production induced by LPS is related to the inhibition effect of 尾-glucan. The phosphorylation of JNK and p38 induced by LPS were not influenced by 尾-glucan, and I魏B-伪 decomposition was not influenced either. Instead, 尾-glucan remarkably inhibited the phosphorylation of STAT1 that was induced by E.coli LPS. Overall, 尾-glucan inhibited the production of NO in macrophagocyte that was vitalized by E.coli LPS through HO-1 induction and STAT1 pathways inhibition in this research. As the host inflammation reaction control by 尾-glucan weakens the progress of allergy, 尾-glucan can be used as an effective treatment method. <iframe src="https://publications.waset.org/abstracts/49496.pdf" style="width:100%; height:400px;" frameborder="0"></iframe> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=%CE%B2-glucan" title="尾-glucan">尾-glucan</a>, <a href="https://publications.waset.org/abstracts/search?q=lipopolysaccharide%20%28LPS%29" title=" lipopolysaccharide (LPS)"> lipopolysaccharide (LPS)</a>, <a href="https://publications.waset.org/abstracts/search?q=nitric%20oxide%20%28NO%29" title=" nitric oxide (NO)"> nitric oxide (NO)</a>, <a href="https://publications.waset.org/abstracts/search?q=RAW264.7%20cells" title=" RAW264.7 cells"> RAW264.7 cells</a>, <a href="https://publications.waset.org/abstracts/search?q=STAT1" title=" STAT1"> STAT1</a> </p> <a href="https://publications.waset.org/abstracts/49496/effects-of-v-glucan-on-the-release-of-nitric-oxide-by-raw2647-cells-stimulated-with-escherichia-coli-lipopolysaccharide" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/49496.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">408</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational 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Effects of 尾-Glucan on the Release of Nitric Oxide by RAW264.7 Cells Stimulated with Escherichia coli Lipopolysaccharide