CINXE.COM

<!DOCTYPE html> <html lang="en" dir="ltr" prefix="content: http://purl.org/rss/1.0/modules/content/ dc: http://purl.org/dc/terms/ foaf: http://xmlns.com/foaf/0.1/ rdfs: http://www.w3.org/2000/01/rdf-schema# sioc: http://rdfs.org/sioc/ns# sioct: http://rdfs.org/sioc/types# skos: http://www.w3.org/2004/02/skos/core# xsd: http://www.w3.org/2001/XMLSchema#"> <head><script type="text/javascript">(window.NREUM||(NREUM={})).init={privacy:{cookies_enabled:true},ajax:{deny_list:[]},session_replay:{sampling_rate:10.0,mask_text_selector:"*",block_selector:"",mask_input_options:{},mask_all_inputs:true,enabled:true,error_sampling_rate:100.0},session_trace:{sampling_rate:10.0,mode:"PROBABILISTIC",enabled:true,error_sampling_rate:100.0}};(window.NREUM||(NREUM={})).loader_config={xpid:"UA8FUVBADwsIV1VaAgMP",licenseKey:"76fb58fb05",applicationID:"788348528"};;/*! For license information please see nr-loader-full-1.274.0.min.js.LICENSE.txt */ (()=>{var e,t,r={8122:(e,t,r)=>{"use strict";r.d(t,{a:()=>i});var n=r(944);function i(e,t){try{if(!e||"object"!=typeof e)return(0,n.R)(3);if(!t||"object"!=typeof t)return(0,n.R)(4);const r=Object.create(Object.getPrototypeOf(t),Object.getOwnPropertyDescriptors(t)),o=0===Object.keys(r).length?e:r;for(let a in o)if(void 0!==e[a])try{if(null===e[a]){r[a]=null;continue}Array.isArray(e[a])&&Array.isArray(t[a])?r[a]=Array.from(new Set([...e[a],...t[a]])):"object"==typeof e[a]&&"object"==typeof t[a]?r[a]=i(e[a],t[a]):r[a]=e[a]}catch(e){(0,n.R)(1,e)}return r}catch(e){(0,n.R)(2,e)}}},2555:(e,t,r)=>{"use strict";r.d(t,{Vp:()=>c,fn:()=>s,x1:()=>d});var n=r(384),i=r(8122);const o={beacon:n.NT.beacon,errorBeacon:n.NT.errorBeacon,licenseKey:void 0,applicationID:void 0,sa:void 0,queueTime:void 0,applicationTime:void 0,ttGuid:void 0,user:void 0,account:void 0,product:void 0,extra:void 0,jsAttributes:{},userAttributes:void 0,atts:void 0,transactionName:void 0,tNamePlain:void 0},a={};function s(e){try{const t=c(e);return!!t.licenseKey&&!!t.errorBeacon&&!!t.applicationID}catch(e){return!1}}function c(e){if(!e)throw new Error("All info objects require an agent identifier!");if(!a[e])throw new Error("Info for ".concat(e," was never set"));return a[e]}function d(e,t){if(!e)throw new Error("All info objects require an agent identifier!");a[e]=(0,i.a)(t,o);const r=(0,n.nY)(e);r&&(r.info=a[e])}},9417:(e,t,r)=>{"use strict";r.d(t,{D0:()=>h,gD:()=>p,xN:()=>g});var n=r(993);const i=e=>{if(!e||"string"!=typeof e)return!1;try{document.createDocumentFragment().querySelector(e)}catch{return!1}return!0};var o=r(2614),a=r(944),s=r(384),c=r(8122);const d="[data-nr-mask]",u=()=>{const e={mask_selector:"*",block_selector:"[data-nr-block]",mask_input_options:{color:!1,date:!1,"datetime-local":!1,email:!1,month:!1,number:!1,range:!1,search:!1,tel:!1,text:!1,time:!1,url:!1,week:!1,textarea:!1,select:!1,password:!0}};return{ajax:{deny_list:void 0,block_internal:!0,enabled:!0,harvestTimeSeconds:10,autoStart:!0},distributed_tracing:{enabled:void 0,exclude_newrelic_header:void 0,cors_use_newrelic_header:void 0,cors_use_tracecontext_headers:void 0,allowed_origins:void 0},feature_flags:[],generic_events:{enabled:!0,harvestTimeSeconds:30,autoStart:!0},harvest:{tooManyRequestsDelay:60},jserrors:{enabled:!0,harvestTimeSeconds:10,autoStart:!0},logging:{enabled:!0,harvestTimeSeconds:10,autoStart:!0,level:n.p_.INFO},metrics:{enabled:!0,autoStart:!0},obfuscate:void 0,page_action:{enabled:!0},page_view_event:{enabled:!0,autoStart:!0},page_view_timing:{enabled:!0,harvestTimeSeconds:30,autoStart:!0},performance:{capture_marks:!1,capture_measures:!1},privacy:{cookies_enabled:!0},proxy:{assets:void 0,beacon:void 0},session:{expiresMs:o.wk,inactiveMs:o.BB},session_replay:{autoStart:!0,enabled:!1,harvestTimeSeconds:60,preload:!1,sampling_rate:10,error_sampling_rate:100,collect_fonts:!1,inline_images:!1,fix_stylesheets:!0,mask_all_inputs:!0,get mask_text_selector(){return e.mask_selector},set mask_text_selector(t){i(t)?e.mask_selector="".concat(t,",").concat(d):""===t||null===t?e.mask_selector=d:(0,a.R)(5,t)},get block_class(){return"nr-block"},get ignore_class(){return"nr-ignore"},get mask_text_class(){return"nr-mask"},get block_selector(){return e.block_selector},set block_selector(t){i(t)?e.block_selector+=",".concat(t):""!==t&&(0,a.R)(6,t)},get mask_input_options(){return e.mask_input_options},set mask_input_options(t){t&&"object"==typeof t?e.mask_input_options={...t,password:!0}:(0,a.R)(7,t)}},session_trace:{enabled:!0,harvestTimeSeconds:10,autoStart:!0},soft_navigations:{enabled:!0,harvestTimeSeconds:10,autoStart:!0},spa:{enabled:!0,harvestTimeSeconds:10,autoStart:!0},ssl:void 0,user_actions:{enabled:!0}}},l={},f="All configuration objects require an agent identifier!";function h(e){if(!e)throw new Error(f);if(!l[e])throw new Error("Configuration for ".concat(e," was never set"));return l[e]}function g(e,t){if(!e)throw new Error(f);l[e]=(0,c.a)(t,u());const r=(0,s.nY)(e);r&&(r.init=l[e])}function p(e,t){if(!e)throw new Error(f);var r=h(e);if(r){for(var n=t.split("."),i=0;i<n.length-1;i++)if("object"!=typeof(r=r[n[i]]))return;r=r[n[n.length-1]]}return r}},5603:(e,t,r)=>{"use strict";r.d(t,{a:()=>c,o:()=>s});var n=r(384),i=r(8122);const o={accountID:void 0,trustKey:void 0,agentID:void 0,licenseKey:void 0,applicationID:void 0,xpid:void 0},a={};function s(e){if(!e)throw new Error("All loader-config objects require an agent identifier!");if(!a[e])throw new Error("LoaderConfig for ".concat(e," was never set"));return a[e]}function c(e,t){if(!e)throw new Error("All loader-config objects require an agent identifier!");a[e]=(0,i.a)(t,o);const r=(0,n.nY)(e);r&&(r.loader_config=a[e])}},3371:(e,t,r)=>{"use strict";r.d(t,{V:()=>f,f:()=>l});var n=r(8122),i=r(384),o=r(6154),a=r(9324);let s=0;const c={buildEnv:a.F3,distMethod:a.Xs,version:a.xv,originTime:o.WN},d={customTransaction:void 0,disabled:!1,isolatedBacklog:!1,loaderType:void 0,maxBytes:3e4,onerror:void 0,ptid:void 0,releaseIds:{},appMetadata:{},session:void 0,denyList:void 0,timeKeeper:void 0,obfuscator:void 0},u={};function l(e){if(!e)throw new Error("All runtime objects require an agent identifier!");if(!u[e])throw new Error("Runtime for ".concat(e," was never set"));return u[e]}function f(e,t){if(!e)throw new Error("All runtime objects require an agent identifier!");u[e]={...(0,n.a)(t,d),...c},Object.hasOwnProperty.call(u[e],"harvestCount")||Object.defineProperty(u[e],"harvestCount",{get:()=>++s});const r=(0,i.nY)(e);r&&(r.runtime=u[e])}},9324:(e,t,r)=>{"use strict";r.d(t,{F3:()=>i,Xs:()=>o,Yq:()=>a,xv:()=>n});const n="1.274.0",i="PROD",o="CDN",a="^2.0.0-alpha.17"},6154:(e,t,r)=>{"use strict";r.d(t,{OF:()=>d,RI:()=>i,WN:()=>f,bv:()=>o,gm:()=>a,lR:()=>l,m:()=>c,mw:()=>s,sb:()=>u});var n=r(1863);const i="undefined"!=typeof window&&!!window.document,o="undefined"!=typeof WorkerGlobalScope&&("undefined"!=typeof self&&self instanceof WorkerGlobalScope&&self.navigator instanceof WorkerNavigator||"undefined"!=typeof globalThis&&globalThis instanceof WorkerGlobalScope&&globalThis.navigator instanceof WorkerNavigator),a=i?window:"undefined"!=typeof WorkerGlobalScope&&("undefined"!=typeof self&&self instanceof WorkerGlobalScope&&self||"undefined"!=typeof globalThis&&globalThis instanceof WorkerGlobalScope&&globalThis),s=Boolean("hidden"===a?.document?.visibilityState),c=""+a?.location,d=/iPad|iPhone|iPod/.test(a.navigator?.userAgent),u=d&&"undefined"==typeof SharedWorker,l=(()=>{const e=a.navigator?.userAgent?.match(/Firefox[/\s](\d+\.\d+)/);return Array.isArray(e)&&e.length>=2?+e[1]:0})(),f=Date.now()-(0,n.t)()},7295:(e,t,r)=>{"use strict";r.d(t,{Xv:()=>a,gX:()=>i,iW:()=>o});var n=[];function i(e){if(!e||o(e))return!1;if(0===n.length)return!0;for(var t=0;t<n.length;t++){var r=n[t];if("*"===r.hostname)return!1;if(s(r.hostname,e.hostname)&&c(r.pathname,e.pathname))return!1}return!0}function o(e){return void 0===e.hostname}function a(e){if(n=[],e&&e.length)for(var t=0;t<e.length;t++){let r=e[t];if(!r)continue;0===r.indexOf("http://")?r=r.substring(7):0===r.indexOf("https://")&&(r=r.substring(8));const i=r.indexOf("/");let o,a;i>0?(o=r.substring(0,i),a=r.substring(i)):(o=r,a="");let[s]=o.split(":");n.push({hostname:s,pathname:a})}}function s(e,t){return!(e.length>t.length)&&t.indexOf(e)===t.length-e.length}function c(e,t){return 0===e.indexOf("/")&&(e=e.substring(1)),0===t.indexOf("/")&&(t=t.substring(1)),""===e||e===t}},1687:(e,t,r)=>{"use strict";r.d(t,{Ak:()=>c,Ze:()=>l,x3:()=>d});var n=r(7836),i=r(3606),o=r(860),a=r(2646);const s={};function c(e,t){const r={staged:!1,priority:o.P3[t]||0};u(e),s[e].get(t)||s[e].set(t,r)}function d(e,t){e&&s[e]&&(s[e].get(t)&&s[e].delete(t),h(e,t,!1),s[e].size&&f(e))}function u(e){if(!e)throw new Error("agentIdentifier required");s[e]||(s[e]=new Map)}function l(e="",t="feature",r=!1){if(u(e),!e||!s[e].get(t)||r)return h(e,t);s[e].get(t).staged=!0,f(e)}function f(e){const t=Array.from(s[e]);t.every((([e,t])=>t.staged))&&(t.sort(((e,t)=>e[1].priority-t[1].priority)),t.forEach((([t])=>{s[e].delete(t),h(e,t)})))}function h(e,t,r=!0){const o=e?n.ee.get(e):n.ee,s=i.i.handlers;if(!o.aborted&&o.backlog&&s){if(r){const e=o.backlog[t],r=s[t];if(r){for(let t=0;e&&t<e.length;++t)g(e[t],r);Object.entries(r).forEach((([e,t])=>{Object.values(t||{}).forEach((t=>{t[0]?.on&&t[0]?.context()instanceof a.y&&t[0].on(e,t[1])}))}))}}o.isolatedBacklog||delete s[t],o.backlog[t]=null,o.emit("drain-"+t,[])}}function g(e,t){var r=e[1];Object.values(t[r]||{}).forEach((t=>{var r=e[0];if(t[0]===r){var n=t[1],i=e[3],o=e[2];n.apply(i,o)}}))}},7836:(e,t,r)=>{"use strict";r.d(t,{P:()=>c,ee:()=>d});var n=r(384),i=r(8990),o=r(3371),a=r(2646),s=r(5607);const c="nr@context:".concat(s.W),d=function e(t,r){var n={},s={},u={},l=!1;try{l=16===r.length&&(0,o.f)(r).isolatedBacklog}catch(e){}var f={on:g,addEventListener:g,removeEventListener:function(e,t){var r=n[e];if(!r)return;for(var i=0;i<r.length;i++)r[i]===t&&r.splice(i,1)},emit:function(e,r,n,i,o){!1!==o&&(o=!0);if(d.aborted&&!i)return;t&&o&&t.emit(e,r,n);for(var a=h(n),c=p(e),u=c.length,l=0;l<u;l++)c[l].apply(a,r);var g=v()[s[e]];g&&g.push([f,e,r,a]);return a},get:m,listeners:p,context:h,buffer:function(e,t){const r=v();if(t=t||"feature",f.aborted)return;Object.entries(e||{}).forEach((([e,n])=>{s[n]=t,t in r||(r[t]=[])}))},abort:function(){f._aborted=!0,Object.keys(f.backlog).forEach((e=>{delete f.backlog[e]}))},isBuffering:function(e){return!!v()[s[e]]},debugId:r,backlog:l?{}:t&&"object"==typeof t.backlog?t.backlog:{},isolatedBacklog:l};return Object.defineProperty(f,"aborted",{get:()=>{let e=f._aborted||!1;return e||(t&&(e=t.aborted),e)}}),f;function h(e){return e&&e instanceof a.y?e:e?(0,i.I)(e,c,(()=>new a.y(c))):new a.y(c)}function g(e,t){n[e]=p(e).concat(t)}function p(e){return n[e]||[]}function m(t){return u[t]=u[t]||e(f,t)}function v(){return f.backlog}}(void 0,"globalEE"),u=(0,n.Zm)();u.ee||(u.ee=d)},2646:(e,t,r)=>{"use strict";r.d(t,{y:()=>n});class n{constructor(e){this.contextId=e}}},9908:(e,t,r)=>{"use strict";r.d(t,{d:()=>n,p:()=>i});var n=r(7836).ee.get("handle");function i(e,t,r,i,o){o?(o.buffer([e],i),o.emit(e,t,r)):(n.buffer([e],i),n.emit(e,t,r))}},3606:(e,t,r)=>{"use strict";r.d(t,{i:()=>o});var n=r(9908);o.on=a;var i=o.handlers={};function o(e,t,r,o){a(o||n.d,i,e,t,r)}function a(e,t,r,i,o){o||(o="feature"),e||(e=n.d);var a=t[o]=t[o]||{};(a[r]=a[r]||[]).push([e,i])}},3878:(e,t,r)=>{"use strict";function n(e,t){return{capture:e,passive:!1,signal:t}}function i(e,t,r=!1,i){window.addEventListener(e,t,n(r,i))}function o(e,t,r=!1,i){document.addEventListener(e,t,n(r,i))}r.d(t,{DD:()=>o,jT:()=>n,sp:()=>i})},5607:(e,t,r)=>{"use strict";r.d(t,{W:()=>n});const n=(0,r(9566).bz)()},9566:(e,t,r)=>{"use strict";r.d(t,{LA:()=>s,ZF:()=>c,bz:()=>a,el:()=>d});var n=r(6154);const i="xxxxxxxx-xxxx-4xxx-yxxx-xxxxxxxxxxxx";function o(e,t){return e?15&e[t]:16*Math.random()|0}function a(){const e=n.gm?.crypto||n.gm?.msCrypto;let t,r=0;return e&&e.getRandomValues&&(t=e.getRandomValues(new Uint8Array(30))),i.split("").map((e=>"x"===e?o(t,r++).toString(16):"y"===e?(3&o()|8).toString(16):e)).join("")}function s(e){const t=n.gm?.crypto||n.gm?.msCrypto;let r,i=0;t&&t.getRandomValues&&(r=t.getRandomValues(new Uint8Array(e)));const a=[];for(var s=0;s<e;s++)a.push(o(r,i++).toString(16));return a.join("")}function c(){return s(16)}function d(){return s(32)}},2614:(e,t,r)=>{"use strict";r.d(t,{BB:()=>a,H3:()=>n,g:()=>d,iL:()=>c,tS:()=>s,uh:()=>i,wk:()=>o});const n="NRBA",i="SESSION",o=144e5,a=18e5,s={STARTED:"session-started",PAUSE:"session-pause",RESET:"session-reset",RESUME:"session-resume",UPDATE:"session-update"},c={SAME_TAB:"same-tab",CROSS_TAB:"cross-tab"},d={OFF:0,FULL:1,ERROR:2}},1863:(e,t,r)=>{"use strict";function n(){return Math.floor(performance.now())}r.d(t,{t:()=>n})},7485:(e,t,r)=>{"use strict";r.d(t,{D:()=>i});var n=r(6154);function i(e){if(0===(e||"").indexOf("data:"))return{protocol:"data"};try{const t=new URL(e,location.href),r={port:t.port,hostname:t.hostname,pathname:t.pathname,search:t.search,protocol:t.protocol.slice(0,t.protocol.indexOf(":")),sameOrigin:t.protocol===n.gm?.location?.protocol&&t.host===n.gm?.location?.host};return r.port&&""!==r.port||("http:"===t.protocol&&(r.port="80"),"https:"===t.protocol&&(r.port="443")),r.pathname&&""!==r.pathname?r.pathname.startsWith("/")||(r.pathname="/".concat(r.pathname)):r.pathname="/",r}catch(e){return{}}}},944:(e,t,r)=>{"use strict";function n(e,t){"function"==typeof console.debug&&console.debug("New Relic Warning: https://github.com/newrelic/newrelic-browser-agent/blob/main/docs/warning-codes.md#".concat(e),t)}r.d(t,{R:()=>n})},5284:(e,t,r)=>{"use strict";r.d(t,{t:()=>c,B:()=>s});var n=r(7836),i=r(6154);const o="newrelic";const a=new Set,s={};function c(e,t){const r=n.ee.get(t);s[t]??={},e&&"object"==typeof e&&(a.has(t)||(r.emit("rumresp",[e]),s[t]=e,a.add(t),function(e={}){try{i.gm.dispatchEvent(new CustomEvent(o,{detail:e}))}catch(e){}}({loaded:!0})))}},8990:(e,t,r)=>{"use strict";r.d(t,{I:()=>i});var n=Object.prototype.hasOwnProperty;function i(e,t,r){if(n.call(e,t))return e[t];var i=r();if(Object.defineProperty&&Object.keys)try{return Object.defineProperty(e,t,{value:i,writable:!0,enumerable:!1}),i}catch(e){}return e[t]=i,i}},6389:(e,t,r)=>{"use strict";function n(e,t=500,r={}){const n=r?.leading||!1;let i;return(...r)=>{n&&void 0===i&&(e.apply(this,r),i=setTimeout((()=>{i=clearTimeout(i)}),t)),n||(clearTimeout(i),i=setTimeout((()=>{e.apply(this,r)}),t))}}function i(e){let t=!1;return(...r)=>{t||(t=!0,e.apply(this,r))}}r.d(t,{J:()=>i,s:()=>n})},3304:(e,t,r)=>{"use strict";r.d(t,{A:()=>o});var n=r(7836);const i=()=>{const e=new WeakSet;return(t,r)=>{if("object"==typeof r&&null!==r){if(e.has(r))return;e.add(r)}return r}};function o(e){try{return JSON.stringify(e,i())??""}catch(e){try{n.ee.emit("internal-error",[e])}catch(e){}return""}}},5289:(e,t,r)=>{"use strict";r.d(t,{GG:()=>o,sB:()=>a});var n=r(3878);function i(){return"undefined"==typeof document||"complete"===document.readyState}function o(e,t){if(i())return e();(0,n.sp)("load",e,t)}function a(e){if(i())return e();(0,n.DD)("DOMContentLoaded",e)}},384:(e,t,r)=>{"use strict";r.d(t,{NT:()=>o,US:()=>u,Zm:()=>a,bQ:()=>c,dV:()=>s,nY:()=>d,pV:()=>l});var n=r(6154),i=r(1863);const o={beacon:"bam.nr-data.net",errorBeacon:"bam.nr-data.net"};function a(){return n.gm.NREUM||(n.gm.NREUM={}),void 0===n.gm.newrelic&&(n.gm.newrelic=n.gm.NREUM),n.gm.NREUM}function s(){let e=a();return e.o||(e.o={ST:n.gm.setTimeout,SI:n.gm.setImmediate,CT:n.gm.clearTimeout,XHR:n.gm.XMLHttpRequest,REQ:n.gm.Request,EV:n.gm.Event,PR:n.gm.Promise,MO:n.gm.MutationObserver,FETCH:n.gm.fetch,WS:n.gm.WebSocket}),e}function c(e,t){let r=a();r.initializedAgents??={},t.initializedAt={ms:(0,i.t)(),date:new Date},r.initializedAgents[e]=t}function d(e){let t=a();return t.initializedAgents?.[e]}function u(e,t){a()[e]=t}function l(){return function(){let e=a();const t=e.info||{};e.info={beacon:o.beacon,errorBeacon:o.errorBeacon,...t}}(),function(){let e=a();const t=e.init||{};e.init={...t}}(),s(),function(){let e=a();const t=e.loader_config||{};e.loader_config={...t}}(),a()}},2843:(e,t,r)=>{"use strict";r.d(t,{u:()=>i});var n=r(3878);function i(e,t=!1,r,i){(0,n.DD)("visibilitychange",(function(){if(t)return void("hidden"===document.visibilityState&&e());e(document.visibilityState)}),r,i)}},8139:(e,t,r)=>{"use strict";r.d(t,{u:()=>f});var n=r(7836),i=r(3434),o=r(8990),a=r(6154);const s={},c=a.gm.XMLHttpRequest,d="addEventListener",u="removeEventListener",l="nr@wrapped:".concat(n.P);function f(e){var t=function(e){return(e||n.ee).get("events")}(e);if(s[t.debugId]++)return t;s[t.debugId]=1;var r=(0,i.YM)(t,!0);function f(e){r.inPlace(e,[d,u],"-",g)}function g(e,t){return e[1]}return"getPrototypeOf"in Object&&(a.RI&&h(document,f),h(a.gm,f),h(c.prototype,f)),t.on(d+"-start",(function(e,t){var n=e[1];if(null!==n&&("function"==typeof n||"object"==typeof n)){var i=(0,o.I)(n,l,(function(){var e={object:function(){if("function"!=typeof n.handleEvent)return;return n.handleEvent.apply(n,arguments)},function:n}[typeof n];return e?r(e,"fn-",null,e.name||"anonymous"):n}));this.wrapped=e[1]=i}})),t.on(u+"-start",(function(e){e[1]=this.wrapped||e[1]})),t}function h(e,t,...r){let n=e;for(;"object"==typeof n&&!Object.prototype.hasOwnProperty.call(n,d);)n=Object.getPrototypeOf(n);n&&t(n,...r)}},3434:(e,t,r)=>{"use strict";r.d(t,{YM:()=>c});var n=r(7836),i=r(5607);const o="nr@original:".concat(i.W);var a=Object.prototype.hasOwnProperty,s=!1;function c(e,t){return e||(e=n.ee),r.inPlace=function(e,t,n,i,o){n||(n="");const a="-"===n.charAt(0);for(let s=0;s<t.length;s++){const c=t[s],d=e[c];u(d)||(e[c]=r(d,a?c+n:n,i,c,o))}},r.flag=o,r;function r(t,r,n,s,c){return u(t)?t:(r||(r=""),nrWrapper[o]=t,function(e,t,r){if(Object.defineProperty&&Object.keys)try{return Object.keys(e).forEach((function(r){Object.defineProperty(t,r,{get:function(){return e[r]},set:function(t){return e[r]=t,t}})})),t}catch(e){d([e],r)}for(var n in e)a.call(e,n)&&(t[n]=e[n])}(t,nrWrapper,e),nrWrapper);function nrWrapper(){var o,a,u,l;try{a=this,o=[...arguments],u="function"==typeof n?n(o,a):n||{}}catch(t){d([t,"",[o,a,s],u],e)}i(r+"start",[o,a,s],u,c);try{return l=t.apply(a,o)}catch(e){throw i(r+"err",[o,a,e],u,c),e}finally{i(r+"end",[o,a,l],u,c)}}}function i(r,n,i,o){if(!s||t){var a=s;s=!0;try{e.emit(r,n,i,t,o)}catch(t){d([t,r,n,i],e)}s=a}}}function d(e,t){t||(t=n.ee);try{t.emit("internal-error",e)}catch(e){}}function u(e){return!(e&&"function"==typeof e&&e.apply&&!e[o])}},9300:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.ajax},3333:(e,t,r)=>{"use strict";r.d(t,{TZ:()=>n,Zp:()=>i,mq:()=>s,nf:()=>a,qN:()=>o});const n=r(860).K7.genericEvents,i=["auxclick","click","copy","keydown","paste","scrollend"],o=["focus","blur"],a=4,s=1e3},6774:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.jserrors},993:(e,t,r)=>{"use strict";r.d(t,{ET:()=>o,TZ:()=>a,p_:()=>i});var n=r(860);const i={ERROR:"ERROR",WARN:"WARN",INFO:"INFO",DEBUG:"DEBUG",TRACE:"TRACE"},o="log",a=n.K7.logging},3785:(e,t,r)=>{"use strict";r.d(t,{R:()=>c,b:()=>d});var n=r(9908),i=r(1863),o=r(860),a=r(3969),s=r(993);function c(e,t,r={},c=s.p_.INFO){(0,n.p)(a.xV,["API/logging/".concat(c.toLowerCase(),"/called")],void 0,o.K7.metrics,e),(0,n.p)(s.ET,[(0,i.t)(),t,r,c],void 0,o.K7.logging,e)}function d(e){return"string"==typeof e&&Object.values(s.p_).some((t=>t===e.toUpperCase().trim()))}},3969:(e,t,r)=>{"use strict";r.d(t,{TZ:()=>n,XG:()=>s,rs:()=>i,xV:()=>a,z_:()=>o});const n=r(860).K7.metrics,i="sm",o="cm",a="storeSupportabilityMetrics",s="storeEventMetrics"},6630:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.pageViewEvent},782:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.pageViewTiming},6344:(e,t,r)=>{"use strict";r.d(t,{BB:()=>u,G4:()=>o,Qb:()=>l,TZ:()=>i,Ug:()=>a,_s:()=>s,bc:()=>d,yP:()=>c});var n=r(2614);const i=r(860).K7.sessionReplay,o={RECORD:"recordReplay",PAUSE:"pauseReplay",REPLAY_RUNNING:"replayRunning",ERROR_DURING_REPLAY:"errorDuringReplay"},a=.12,s={DomContentLoaded:0,Load:1,FullSnapshot:2,IncrementalSnapshot:3,Meta:4,Custom:5},c={[n.g.ERROR]:15e3,[n.g.FULL]:3e5,[n.g.OFF]:0},d={RESET:{message:"Session was reset",sm:"Reset"},IMPORT:{message:"Recorder failed to import",sm:"Import"},TOO_MANY:{message:"429: Too Many Requests",sm:"Too-Many"},TOO_BIG:{message:"Payload was too large",sm:"Too-Big"},CROSS_TAB:{message:"Session Entity was set to OFF on another tab",sm:"Cross-Tab"},ENTITLEMENTS:{message:"Session Replay is not allowed and will not be started",sm:"Entitlement"}},u=5e3,l={API:"api"}},5270:(e,t,r)=>{"use strict";r.d(t,{Aw:()=>c,CT:()=>d,SR:()=>s});var n=r(384),i=r(9417),o=r(7767),a=r(6154);function s(e){return!!(0,n.dV)().o.MO&&(0,o.V)(e)&&!0===(0,i.gD)(e,"session_trace.enabled")}function c(e){return!0===(0,i.gD)(e,"session_replay.preload")&&s(e)}function d(e,t){const r=t.correctAbsoluteTimestamp(e);return{originalTimestamp:e,correctedTimestamp:r,timestampDiff:e-r,originTime:a.WN,correctedOriginTime:t.correctedOriginTime,originTimeDiff:Math.floor(a.WN-t.correctedOriginTime)}}},3738:(e,t,r)=>{"use strict";r.d(t,{He:()=>i,Kp:()=>s,Lc:()=>d,Rz:()=>u,TZ:()=>n,bD:()=>o,d3:()=>a,jx:()=>l,uP:()=>c});const n=r(860).K7.sessionTrace,i="bstResource",o="resource",a="-start",s="-end",c="fn"+a,d="fn"+s,u="pushState",l=1e3},4234:(e,t,r)=>{"use strict";r.d(t,{W:()=>o});var n=r(7836),i=r(1687);class o{constructor(e,t){this.agentIdentifier=e,this.ee=n.ee.get(e),this.featureName=t,this.blocked=!1}deregisterDrain(){(0,i.x3)(this.agentIdentifier,this.featureName)}}},7767:(e,t,r)=>{"use strict";r.d(t,{V:()=>o});var n=r(9417),i=r(6154);const o=e=>i.RI&&!0===(0,n.gD)(e,"privacy.cookies_enabled")},425:(e,t,r)=>{"use strict";r.d(t,{j:()=>P});var n=r(860),i=r(2555),o=r(3371),a=r(9908),s=r(7836),c=r(1687),d=r(5289),u=r(6154),l=r(944),f=r(3969),h=r(384),g=r(6344);const p=["setErrorHandler","finished","addToTrace","addRelease","addPageAction","setCurrentRouteName","setPageViewName","setCustomAttribute","interaction","noticeError","setUserId","setApplicationVersion","start",g.G4.RECORD,g.G4.PAUSE,"log","wrapLogger"],m=["setErrorHandler","finished","addToTrace","addRelease"];var v=r(1863),b=r(2614),y=r(993),R=r(3785),x=r(2646),w=r(3434);function T(e,t,r,n){if("object"!=typeof t||!t||"string"!=typeof r||!r||"function"!=typeof t[r])return(0,l.R)(29);const i=function(e){return(e||s.ee).get("logger")}(e),o=(0,w.YM)(i),a=new x.y(s.P);return a.level=n.level,a.customAttributes=n.customAttributes,o.inPlace(t,[r],"wrap-logger-",a),i}function A(){const e=(0,h.pV)();p.forEach((t=>{e[t]=(...r)=>function(t,...r){let n=[];return Object.values(e.initializedAgents).forEach((e=>{e&&e.api?e.exposed&&e.api[t]&&n.push(e.api[t](...r)):(0,l.R)(38,t)})),n.length>1?n:n[0]}(t,...r)}))}const E={};var S=r(9417),_=r(5603),O=r(5284);const N=e=>{const t=e.startsWith("http");e+="/",r.p=t?e:"https://"+e};let I=!1;function P(e,t={},p,x){let{init:w,info:P,loader_config:j,runtime:C={},exposed:k=!0}=t;C.loaderType=p;const H=(0,h.pV)();P||(w=H.init,P=H.info,j=H.loader_config),(0,S.xN)(e.agentIdentifier,w||{}),(0,_.a)(e.agentIdentifier,j||{}),P.jsAttributes??={},u.bv&&(P.jsAttributes.isWorker=!0),(0,i.x1)(e.agentIdentifier,P);const D=(0,S.D0)(e.agentIdentifier),L=[P.beacon,P.errorBeacon];I||(D.proxy.assets&&(N(D.proxy.assets),L.push(D.proxy.assets)),D.proxy.beacon&&L.push(D.proxy.beacon),A(),(0,h.US)("activatedFeatures",O.B),e.runSoftNavOverSpa&&=!0===D.soft_navigations.enabled&&D.feature_flags.includes("soft_nav")),C.denyList=[...D.ajax.deny_list||[],...D.ajax.block_internal?L:[]],C.ptid=e.agentIdentifier,(0,o.V)(e.agentIdentifier,C),e.ee=s.ee.get(e.agentIdentifier),void 0===e.api&&(e.api=function(e,t,h=!1){t||(0,c.Ak)(e,"api");const p={};var x=s.ee.get(e),w=x.get("tracer");E[e]=b.g.OFF,x.on(g.G4.REPLAY_RUNNING,(t=>{E[e]=t}));var A="api-",S=A+"ixn-";function _(t,r,n,o){const a=(0,i.Vp)(e);return null===r?delete a.jsAttributes[t]:(0,i.x1)(e,{...a,jsAttributes:{...a.jsAttributes,[t]:r}}),I(A,n,!0,o||null===r?"session":void 0)(t,r)}function O(){}p.log=function(e,{customAttributes:t={},level:r=y.p_.INFO}={}){(0,a.p)(f.xV,["API/log/called"],void 0,n.K7.metrics,x),(0,R.R)(x,e,t,r)},p.wrapLogger=(e,t,{customAttributes:r={},level:i=y.p_.INFO}={})=>{(0,a.p)(f.xV,["API/wrapLogger/called"],void 0,n.K7.metrics,x),T(x,e,t,{customAttributes:r,level:i})},m.forEach((e=>{p[e]=I(A,e,!0,"api")})),p.addPageAction=I(A,"addPageAction",!0,n.K7.genericEvents),p.setPageViewName=function(t,r){if("string"==typeof t)return"/"!==t.charAt(0)&&(t="/"+t),(0,o.f)(e).customTransaction=(r||"http://custom.transaction")+t,I(A,"setPageViewName",!0)()},p.setCustomAttribute=function(e,t,r=!1){if("string"==typeof e){if(["string","number","boolean"].includes(typeof t)||null===t)return _(e,t,"setCustomAttribute",r);(0,l.R)(40,typeof t)}else(0,l.R)(39,typeof e)},p.setUserId=function(e){if("string"==typeof e||null===e)return _("enduser.id",e,"setUserId",!0);(0,l.R)(41,typeof e)},p.setApplicationVersion=function(e){if("string"==typeof e||null===e)return _("application.version",e,"setApplicationVersion",!1);(0,l.R)(42,typeof e)},p.start=()=>{try{(0,a.p)(f.xV,["API/start/called"],void 0,n.K7.metrics,x),x.emit("manual-start-all")}catch(e){(0,l.R)(23,e)}},p[g.G4.RECORD]=function(){(0,a.p)(f.xV,["API/recordReplay/called"],void 0,n.K7.metrics,x),(0,a.p)(g.G4.RECORD,[],void 0,n.K7.sessionReplay,x)},p[g.G4.PAUSE]=function(){(0,a.p)(f.xV,["API/pauseReplay/called"],void 0,n.K7.metrics,x),(0,a.p)(g.G4.PAUSE,[],void 0,n.K7.sessionReplay,x)},p.interaction=function(e){return(new O).get("object"==typeof e?e:{})};const N=O.prototype={createTracer:function(e,t){var r={},i=this,o="function"==typeof t;return(0,a.p)(f.xV,["API/createTracer/called"],void 0,n.K7.metrics,x),h||(0,a.p)(S+"tracer",[(0,v.t)(),e,r],i,n.K7.spa,x),function(){if(w.emit((o?"":"no-")+"fn-start",[(0,v.t)(),i,o],r),o)try{return t.apply(this,arguments)}catch(e){const t="string"==typeof e?new Error(e):e;throw w.emit("fn-err",[arguments,this,t],r),t}finally{w.emit("fn-end",[(0,v.t)()],r)}}}};function I(e,t,r,i){return function(){return(0,a.p)(f.xV,["API/"+t+"/called"],void 0,n.K7.metrics,x),i&&(0,a.p)(e+t,[(0,v.t)(),...arguments],r?null:this,i,x),r?void 0:this}}function P(){r.e(891).then(r.bind(r,8778)).then((({setAPI:t})=>{t(e),(0,c.Ze)(e,"api")})).catch((e=>{(0,l.R)(27,e),x.abort()}))}return["actionText","setName","setAttribute","save","ignore","onEnd","getContext","end","get"].forEach((e=>{N[e]=I(S,e,void 0,h?n.K7.softNav:n.K7.spa)})),p.setCurrentRouteName=h?I(S,"routeName",void 0,n.K7.softNav):I(A,"routeName",!0,n.K7.spa),p.noticeError=function(t,r){"string"==typeof t&&(t=new Error(t)),(0,a.p)(f.xV,["API/noticeError/called"],void 0,n.K7.metrics,x),(0,a.p)("err",[t,(0,v.t)(),!1,r,!!E[e]],void 0,n.K7.jserrors,x)},u.RI?(0,d.GG)((()=>P()),!0):P(),p}(e.agentIdentifier,x,e.runSoftNavOverSpa)),void 0===e.exposed&&(e.exposed=k),I=!0}},8374:(e,t,r)=>{r.nc=(()=>{try{return document?.currentScript?.nonce}catch(e){}return""})()},860:(e,t,r)=>{"use strict";r.d(t,{$J:()=>o,K7:()=>n,P3:()=>i});const n={ajax:"ajax",genericEvents:"generic_events",jserrors:"jserrors",logging:"logging",metrics:"metrics",pageAction:"page_action",pageViewEvent:"page_view_event",pageViewTiming:"page_view_timing",sessionReplay:"session_replay",sessionTrace:"session_trace",softNav:"soft_navigations",spa:"spa"},i={[n.pageViewEvent]:1,[n.pageViewTiming]:2,[n.metrics]:3,[n.jserrors]:4,[n.spa]:5,[n.ajax]:6,[n.sessionTrace]:7,[n.softNav]:8,[n.sessionReplay]:9,[n.logging]:10,[n.genericEvents]:11},o={[n.pageViewTiming]:"events",[n.ajax]:"events",[n.spa]:"events",[n.softNav]:"events",[n.metrics]:"jserrors",[n.jserrors]:"jserrors",[n.sessionTrace]:"browser/blobs",[n.sessionReplay]:"browser/blobs",[n.logging]:"browser/logs",[n.genericEvents]:"ins"}}},n={};function i(e){var t=n[e];if(void 0!==t)return t.exports;var o=n[e]={exports:{}};return r[e](o,o.exports,i),o.exports}i.m=r,i.d=(e,t)=>{for(var r in t)i.o(t,r)&&!i.o(e,r)&&Object.defineProperty(e,r,{enumerable:!0,get:t[r]})},i.f={},i.e=e=>Promise.all(Object.keys(i.f).reduce(((t,r)=>(i.f[r](e,t),t)),[])),i.u=e=>({95:"nr-full-compressor",222:"nr-full-recorder",891:"nr-full"}[e]+"-1.274.0.min.js"),i.o=(e,t)=>Object.prototype.hasOwnProperty.call(e,t),e={},t="NRBA-1.274.0.PROD:",i.l=(r,n,o,a)=>{if(e[r])e[r].push(n);else{var s,c;if(void 0!==o)for(var d=document.getElementsByTagName("script"),u=0;u<d.length;u++){var l=d[u];if(l.getAttribute("src")==r||l.getAttribute("data-webpack")==t+o){s=l;break}}if(!s){c=!0;var f={891:"sha512-Sx2xJQrHp2m/Ngn/ZcfBCUwNr2Xy/C5urYtWpfm3bWpil4spXOQGTtNwIfF5HvPGioGASn9QTyE4Z+zC7r7wcg==",222:"sha512-hMte3OWgwwYeisSiD7WCIx/6tT16zLaPjag9uF4tIZp7ybOvrJKbeyzhe4fz1tDbkdcdOMm8dvgPPLBatSAGeA==",95:"sha512-MPaT9dkHv16XzwEUVZPyqpN1do/Er1XFAZoIAPYWylmv+iGIThqN+GwQq27pUyAX7sNXVJQVZezH96p53Ks3Pg=="};(s=document.createElement("script")).charset="utf-8",s.timeout=120,i.nc&&s.setAttribute("nonce",i.nc),s.setAttribute("data-webpack",t+o),s.src=r,0!==s.src.indexOf(window.location.origin+"/")&&(s.crossOrigin="anonymous"),f[a]&&(s.integrity=f[a])}e[r]=[n];var h=(t,n)=>{s.onerror=s.onload=null,clearTimeout(g);var i=e[r];if(delete e[r],s.parentNode&&s.parentNode.removeChild(s),i&&i.forEach((e=>e(n))),t)return t(n)},g=setTimeout(h.bind(null,void 0,{type:"timeout",target:s}),12e4);s.onerror=h.bind(null,s.onerror),s.onload=h.bind(null,s.onload),c&&document.head.appendChild(s)}},i.r=e=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(e,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(e,"__esModule",{value:!0})},i.p="https://js-agent.newrelic.com/",(()=>{var e={959:0,85:0};i.f.j=(t,r)=>{var n=i.o(e,t)?e[t]:void 0;if(0!==n)if(n)r.push(n[2]);else{var o=new Promise(((r,i)=>n=e[t]=[r,i]));r.push(n[2]=o);var a=i.p+i.u(t),s=new Error;i.l(a,(r=>{if(i.o(e,t)&&(0!==(n=e[t])&&(e[t]=void 0),n)){var o=r&&("load"===r.type?"missing":r.type),a=r&&r.target&&r.target.src;s.message="Loading chunk "+t+" failed.\n("+o+": "+a+")",s.name="ChunkLoadError",s.type=o,s.request=a,n[1](s)}}),"chunk-"+t,t)}};var t=(t,r)=>{var n,o,[a,s,c]=r,d=0;if(a.some((t=>0!==e[t]))){for(n in s)i.o(s,n)&&(i.m[n]=s[n]);if(c)c(i)}for(t&&t(r);d<a.length;d++)o=a[d],i.o(e,o)&&e[o]&&e[o][0](),e[o]=0},r=self["webpackChunk:NRBA-1.274.0.PROD"]=self["webpackChunk:NRBA-1.274.0.PROD"]||[];r.forEach(t.bind(null,0)),r.push=t.bind(null,r.push.bind(r))})(),(()=>{"use strict";i(8374);var e=i(944),t=i(6344),r=i(9566);class n{agentIdentifier;constructor(e=(0,r.LA)(16)){this.agentIdentifier=e}#e(t,...r){if("function"==typeof this.api?.[t])return this.api[t](...r);(0,e.R)(35,t)}addPageAction(e,t){return this.#e("addPageAction",e,t)}setPageViewName(e,t){return this.#e("setPageViewName",e,t)}setCustomAttribute(e,t,r){return this.#e("setCustomAttribute",e,t,r)}noticeError(e,t){return this.#e("noticeError",e,t)}setUserId(e){return this.#e("setUserId",e)}setApplicationVersion(e){return this.#e("setApplicationVersion",e)}setErrorHandler(e){return this.#e("setErrorHandler",e)}addRelease(e,t){return this.#e("addRelease",e,t)}log(e,t){return this.#e("log",e,t)}}class o extends n{#e(t,...r){if("function"==typeof this.api?.[t])return this.api[t](...r);(0,e.R)(35,t)}start(){return this.#e("start")}finished(e){return this.#e("finished",e)}recordReplay(){return this.#e(t.G4.RECORD)}pauseReplay(){return this.#e(t.G4.PAUSE)}addToTrace(e){return this.#e("addToTrace",e)}setCurrentRouteName(e){return this.#e("setCurrentRouteName",e)}interaction(){return this.#e("interaction")}wrapLogger(e,t,r){return this.#e("wrapLogger",e,t,r)}}var a=i(860),s=i(9417);const c=Object.values(a.K7);function d(e){const t={};return c.forEach((r=>{t[r]=function(e,t){return!0===(0,s.gD)(t,"".concat(e,".enabled"))}(r,e)})),t}var u=i(425);var l=i(1687),f=i(4234),h=i(5289),g=i(6154),p=i(5270),m=i(7767),v=i(6389);class b extends f.W{constructor(e,t,r=!0){super(e.agentIdentifier,t),this.auto=r,this.abortHandler=void 0,this.featAggregate=void 0,this.onAggregateImported=void 0,!1===e.init[this.featureName].autoStart&&(this.auto=!1),this.auto?(0,l.Ak)(e.agentIdentifier,t):this.ee.on("manual-start-all",(0,v.J)((()=>{(0,l.Ak)(e.agentIdentifier,this.featureName),this.auto=!0,this.importAggregator(e)})))}importAggregator(t,r={}){if(this.featAggregate||!this.auto)return;let n;this.onAggregateImported=new Promise((e=>{n=e}));const o=async()=>{let o;try{if((0,m.V)(this.agentIdentifier)){const{setupAgentSession:e}=await i.e(891).then(i.bind(i,6526));o=e(t)}}catch(t){(0,e.R)(20,t),this.ee.emit("internal-error",[t]),this.featureName===a.K7.sessionReplay&&this.abortHandler?.()}try{if(t.sharedAggregator)await t.sharedAggregator;else{t.sharedAggregator=i.e(891).then(i.bind(i,9337));const{EventAggregator:e}=await t.sharedAggregator;t.sharedAggregator=new e}if(!this.#t(this.featureName,o))return(0,l.Ze)(this.agentIdentifier,this.featureName),void n(!1);const{lazyFeatureLoader:e}=await i.e(891).then(i.bind(i,6103)),{Aggregate:a}=await e(this.featureName,"aggregate");this.featAggregate=new a(t,r),n(!0)}catch(t){(0,e.R)(34,t),this.abortHandler?.(),(0,l.Ze)(this.agentIdentifier,this.featureName,!0),n(!1),this.ee&&this.ee.abort()}};g.RI?(0,h.GG)((()=>o()),!0):o()}#t(e,t){switch(e){case a.K7.sessionReplay:return(0,p.SR)(this.agentIdentifier)&&!!t;case a.K7.sessionTrace:return!!t;default:return!0}}}var y=i(6630);class R extends b{static featureName=y.T;constructor(e,t=!0){super(e,y.T,t),this.importAggregator(e)}}var x=i(384);var w=i(9908),T=i(2843),A=i(3878),E=i(782),S=i(1863);class _ extends b{static featureName=E.T;constructor(e,t=!0){super(e,E.T,t),g.RI&&((0,T.u)((()=>(0,w.p)("docHidden",[(0,S.t)()],void 0,E.T,this.ee)),!0),(0,A.sp)("pagehide",(()=>(0,w.p)("winPagehide",[(0,S.t)()],void 0,E.T,this.ee))),this.importAggregator(e))}}var O=i(3969);class N extends b{static featureName=O.TZ;constructor(e,t=!0){super(e,O.TZ,t),this.importAggregator(e)}}var I=i(6774),P=i(3304);class j{constructor(e,t,r,n,i){this.name="UncaughtError",this.message="string"==typeof e?e:(0,P.A)(e),this.sourceURL=t,this.line=r,this.column=n,this.__newrelic=i}}function C(e){return D(e)?e:new j(void 0!==e?.message?e.message:e,e?.filename||e?.sourceURL,e?.lineno||e?.line,e?.colno||e?.col,e?.__newrelic)}function k(e){const t="Unhandled Promise Rejection";if(!e?.reason)return;if(D(e.reason))try{return e.reason.message=t+": "+e.reason.message,C(e.reason)}catch(t){return C(e.reason)}const r=C(e.reason);return r.message=t+": "+r?.message,r}function H(e){if(e.error instanceof SyntaxError&&!/:\d+$/.test(e.error.stack?.trim())){const t=new j(e.message,e.filename,e.lineno,e.colno,e.error.__newrelic);return t.name=SyntaxError.name,t}return D(e.error)?e.error:C(e)}function D(e){return e instanceof Error&&!!e.stack}class L extends b{static featureName=I.T;#r=!1;constructor(e,r=!0){super(e,I.T,r);try{this.removeOnAbort=new AbortController}catch(e){}this.ee.on("internal-error",(e=>{this.abortHandler&&(0,w.p)("ierr",[C(e),(0,S.t)(),!0,{},this.#r],void 0,this.featureName,this.ee)})),this.ee.on(t.G4.REPLAY_RUNNING,(e=>{this.#r=e})),g.gm.addEventListener("unhandledrejection",(e=>{this.abortHandler&&(0,w.p)("err",[k(e),(0,S.t)(),!1,{unhandledPromiseRejection:1},this.#r],void 0,this.featureName,this.ee)}),(0,A.jT)(!1,this.removeOnAbort?.signal)),g.gm.addEventListener("error",(e=>{this.abortHandler&&(0,w.p)("err",[H(e),(0,S.t)(),!1,{},this.#r],void 0,this.featureName,this.ee)}),(0,A.jT)(!1,this.removeOnAbort?.signal)),this.abortHandler=this.#n,this.importAggregator(e)}#n(){this.removeOnAbort?.abort(),this.abortHandler=void 0}}var K=i(8990);let M=1;const U="nr@id";function V(e){const t=typeof e;return!e||"object"!==t&&"function"!==t?-1:e===g.gm?0:(0,K.I)(e,U,(function(){return M++}))}function G(e){if("string"==typeof e&&e.length)return e.length;if("object"==typeof e){if("undefined"!=typeof ArrayBuffer&&e instanceof ArrayBuffer&&e.byteLength)return e.byteLength;if("undefined"!=typeof Blob&&e instanceof Blob&&e.size)return e.size;if(!("undefined"!=typeof FormData&&e instanceof FormData))try{return(0,P.A)(e).length}catch(e){return}}}var F=i(8139),B=i(7836),W=i(3434);const z={},q=["open","send"];function Z(t){var r=t||B.ee;const n=function(e){return(e||B.ee).get("xhr")}(r);if(z[n.debugId]++)return n;z[n.debugId]=1,(0,F.u)(r);var i=(0,W.YM)(n),o=g.gm.XMLHttpRequest,a=g.gm.MutationObserver,s=g.gm.Promise,c=g.gm.setInterval,d="readystatechange",u=["onload","onerror","onabort","onloadstart","onloadend","onprogress","ontimeout"],l=[],f=g.gm.XMLHttpRequest=function(t){const r=new o(t),a=n.context(r);try{n.emit("new-xhr",[r],a),r.addEventListener(d,(s=a,function(){var e=this;e.readyState>3&&!s.resolved&&(s.resolved=!0,n.emit("xhr-resolved",[],e)),i.inPlace(e,u,"fn-",y)}),(0,A.jT)(!1))}catch(t){(0,e.R)(15,t);try{n.emit("internal-error",[t])}catch(e){}}var s;return r};function h(e,t){i.inPlace(t,["onreadystatechange"],"fn-",y)}if(function(e,t){for(var r in e)t[r]=e[r]}(o,f),f.prototype=o.prototype,i.inPlace(f.prototype,q,"-xhr-",y),n.on("send-xhr-start",(function(e,t){h(e,t),function(e){l.push(e),a&&(p?p.then(b):c?c(b):(m=-m,v.data=m))}(t)})),n.on("open-xhr-start",h),a){var p=s&&s.resolve();if(!c&&!s){var m=1,v=document.createTextNode(m);new a(b).observe(v,{characterData:!0})}}else r.on("fn-end",(function(e){e[0]&&e[0].type===d||b()}));function b(){for(var e=0;e<l.length;e++)h(0,l[e]);l.length&&(l=[])}function y(e,t){return t}return n}var Y="fetch-",X=Y+"body-",Q=["arrayBuffer","blob","json","text","formData"],J=g.gm.Request,ee=g.gm.Response,te="prototype";const re={};function ne(e){const t=function(e){return(e||B.ee).get("fetch")}(e);if(!(J&&ee&&g.gm.fetch))return t;if(re[t.debugId]++)return t;function r(e,r,n){var i=e[r];"function"==typeof i&&(e[r]=function(){var e,r=[...arguments],o={};t.emit(n+"before-start",[r],o),o[B.P]&&o[B.P].dt&&(e=o[B.P].dt);var a=i.apply(this,r);return t.emit(n+"start",[r,e],a),a.then((function(e){return t.emit(n+"end",[null,e],a),e}),(function(e){throw t.emit(n+"end",[e],a),e}))})}return re[t.debugId]=1,Q.forEach((e=>{r(J[te],e,X),r(ee[te],e,X)})),r(g.gm,"fetch",Y),t.on(Y+"end",(function(e,r){var n=this;if(r){var i=r.headers.get("content-length");null!==i&&(n.rxSize=i),t.emit(Y+"done",[null,r],n)}else t.emit(Y+"done",[e],n)})),t}var ie=i(7485),oe=i(5603);class ae{constructor(e){this.agentIdentifier=e}generateTracePayload(e){if(!this.shouldGenerateTrace(e))return null;var t=(0,oe.o)(this.agentIdentifier);if(!t)return null;var n=(t.accountID||"").toString()||null,i=(t.agentID||"").toString()||null,o=(t.trustKey||"").toString()||null;if(!n||!i)return null;var a=(0,r.ZF)(),s=(0,r.el)(),c=Date.now(),d={spanId:a,traceId:s,timestamp:c};return(e.sameOrigin||this.isAllowedOrigin(e)&&this.useTraceContextHeadersForCors())&&(d.traceContextParentHeader=this.generateTraceContextParentHeader(a,s),d.traceContextStateHeader=this.generateTraceContextStateHeader(a,c,n,i,o)),(e.sameOrigin&&!this.excludeNewrelicHeader()||!e.sameOrigin&&this.isAllowedOrigin(e)&&this.useNewrelicHeaderForCors())&&(d.newrelicHeader=this.generateTraceHeader(a,s,c,n,i,o)),d}generateTraceContextParentHeader(e,t){return"00-"+t+"-"+e+"-01"}generateTraceContextStateHeader(e,t,r,n,i){return i+"@nr=0-1-"+r+"-"+n+"-"+e+"----"+t}generateTraceHeader(e,t,r,n,i,o){if(!("function"==typeof g.gm?.btoa))return null;var a={v:[0,1],d:{ty:"Browser",ac:n,ap:i,id:e,tr:t,ti:r}};return o&&n!==o&&(a.d.tk=o),btoa((0,P.A)(a))}shouldGenerateTrace(e){return this.isDtEnabled()&&this.isAllowedOrigin(e)}isAllowedOrigin(e){var t=!1,r={};if((0,s.gD)(this.agentIdentifier,"distributed_tracing")&&(r=(0,s.D0)(this.agentIdentifier).distributed_tracing),e.sameOrigin)t=!0;else if(r.allowed_origins instanceof Array)for(var n=0;n<r.allowed_origins.length;n++){var i=(0,ie.D)(r.allowed_origins[n]);if(e.hostname===i.hostname&&e.protocol===i.protocol&&e.port===i.port){t=!0;break}}return t}isDtEnabled(){var e=(0,s.gD)(this.agentIdentifier,"distributed_tracing");return!!e&&!!e.enabled}excludeNewrelicHeader(){var e=(0,s.gD)(this.agentIdentifier,"distributed_tracing");return!!e&&!!e.exclude_newrelic_header}useNewrelicHeaderForCors(){var e=(0,s.gD)(this.agentIdentifier,"distributed_tracing");return!!e&&!1!==e.cors_use_newrelic_header}useTraceContextHeadersForCors(){var e=(0,s.gD)(this.agentIdentifier,"distributed_tracing");return!!e&&!!e.cors_use_tracecontext_headers}}var se=i(9300),ce=i(7295),de=["load","error","abort","timeout"],ue=de.length,le=(0,x.dV)().o.REQ,fe=(0,x.dV)().o.XHR;class he extends b{static featureName=se.T;constructor(e,t=!0){super(e,se.T,t),this.dt=new ae(e.agentIdentifier),this.handler=(e,t,r,n)=>(0,w.p)(e,t,r,n,this.ee);try{const e={xmlhttprequest:"xhr",fetch:"fetch",beacon:"beacon"};g.gm?.performance?.getEntriesByType("resource").forEach((t=>{if(t.initiatorType in e&&0!==t.responseStatus){const r={status:t.responseStatus},n={rxSize:t.transferSize,duration:Math.floor(t.duration),cbTime:0};ge(r,t.name),this.handler("xhr",[r,n,t.startTime,t.responseEnd,e[t.initiatorType]],void 0,a.K7.ajax)}}))}catch(e){}ne(this.ee),Z(this.ee),function(e,t,r,n){function i(e){var t=this;t.totalCbs=0,t.called=0,t.cbTime=0,t.end=x,t.ended=!1,t.xhrGuids={},t.lastSize=null,t.loadCaptureCalled=!1,t.params=this.params||{},t.metrics=this.metrics||{},e.addEventListener("load",(function(r){T(t,e)}),(0,A.jT)(!1)),g.lR||e.addEventListener("progress",(function(e){t.lastSize=e.loaded}),(0,A.jT)(!1))}function o(e){this.params={method:e[0]},ge(this,e[1]),this.metrics={}}function s(t,r){e.loader_config.xpid&&this.sameOrigin&&r.setRequestHeader("X-NewRelic-ID",e.loader_config.xpid);var i=n.generateTracePayload(this.parsedOrigin);if(i){var o=!1;i.newrelicHeader&&(r.setRequestHeader("newrelic",i.newrelicHeader),o=!0),i.traceContextParentHeader&&(r.setRequestHeader("traceparent",i.traceContextParentHeader),i.traceContextStateHeader&&r.setRequestHeader("tracestate",i.traceContextStateHeader),o=!0),o&&(this.dt=i)}}function c(e,r){var n=this.metrics,i=e[0],o=this;if(n&&i){var a=G(i);a&&(n.txSize=a)}this.startTime=(0,S.t)(),this.body=i,this.listener=function(e){try{"abort"!==e.type||o.loadCaptureCalled||(o.params.aborted=!0),("load"!==e.type||o.called===o.totalCbs&&(o.onloadCalled||"function"!=typeof r.onload)&&"function"==typeof o.end)&&o.end(r)}catch(e){try{t.emit("internal-error",[e])}catch(e){}}};for(var s=0;s<ue;s++)r.addEventListener(de[s],this.listener,(0,A.jT)(!1))}function d(e,t,r){this.cbTime+=e,t?this.onloadCalled=!0:this.called+=1,this.called!==this.totalCbs||!this.onloadCalled&&"function"==typeof r.onload||"function"!=typeof this.end||this.end(r)}function u(e,t){var r=""+V(e)+!!t;this.xhrGuids&&!this.xhrGuids[r]&&(this.xhrGuids[r]=!0,this.totalCbs+=1)}function l(e,t){var r=""+V(e)+!!t;this.xhrGuids&&this.xhrGuids[r]&&(delete this.xhrGuids[r],this.totalCbs-=1)}function f(){this.endTime=(0,S.t)()}function h(e,r){r instanceof fe&&"load"===e[0]&&t.emit("xhr-load-added",[e[1],e[2]],r)}function p(e,r){r instanceof fe&&"load"===e[0]&&t.emit("xhr-load-removed",[e[1],e[2]],r)}function m(e,t,r){t instanceof fe&&("onload"===r&&(this.onload=!0),("load"===(e[0]&&e[0].type)||this.onload)&&(this.xhrCbStart=(0,S.t)()))}function v(e,r){this.xhrCbStart&&t.emit("xhr-cb-time",[(0,S.t)()-this.xhrCbStart,this.onload,r],r)}function b(e){var t,r=e[1]||{};if("string"==typeof e[0]?0===(t=e[0]).length&&g.RI&&(t=""+g.gm.location.href):e[0]&&e[0].url?t=e[0].url:g.gm?.URL&&e[0]&&e[0]instanceof URL?t=e[0].href:"function"==typeof e[0].toString&&(t=e[0].toString()),"string"==typeof t&&0!==t.length){t&&(this.parsedOrigin=(0,ie.D)(t),this.sameOrigin=this.parsedOrigin.sameOrigin);var i=n.generateTracePayload(this.parsedOrigin);if(i&&(i.newrelicHeader||i.traceContextParentHeader))if(e[0]&&e[0].headers)s(e[0].headers,i)&&(this.dt=i);else{var o={};for(var a in r)o[a]=r[a];o.headers=new Headers(r.headers||{}),s(o.headers,i)&&(this.dt=i),e.length>1?e[1]=o:e.push(o)}}function s(e,t){var r=!1;return t.newrelicHeader&&(e.set("newrelic",t.newrelicHeader),r=!0),t.traceContextParentHeader&&(e.set("traceparent",t.traceContextParentHeader),t.traceContextStateHeader&&e.set("tracestate",t.traceContextStateHeader),r=!0),r}}function y(e,t){this.params={},this.metrics={},this.startTime=(0,S.t)(),this.dt=t,e.length>=1&&(this.target=e[0]),e.length>=2&&(this.opts=e[1]);var r,n=this.opts||{},i=this.target;"string"==typeof i?r=i:"object"==typeof i&&i instanceof le?r=i.url:g.gm?.URL&&"object"==typeof i&&i instanceof URL&&(r=i.href),ge(this,r);var o=(""+(i&&i instanceof le&&i.method||n.method||"GET")).toUpperCase();this.params.method=o,this.body=n.body,this.txSize=G(n.body)||0}function R(e,t){if(this.endTime=(0,S.t)(),this.params||(this.params={}),(0,ce.iW)(this.params))return;let n;this.params.status=t?t.status:0,"string"==typeof this.rxSize&&this.rxSize.length>0&&(n=+this.rxSize);const i={txSize:this.txSize,rxSize:n,duration:(0,S.t)()-this.startTime};r("xhr",[this.params,i,this.startTime,this.endTime,"fetch"],this,a.K7.ajax)}function x(e){const t=this.params,n=this.metrics;if(!this.ended){this.ended=!0;for(let t=0;t<ue;t++)e.removeEventListener(de[t],this.listener,!1);t.aborted||(0,ce.iW)(t)||(n.duration=(0,S.t)()-this.startTime,this.loadCazptureCalled||4!==e.readyState?null==t.status&&(t.status=0):T(this,e),n.cbTime=this.cbTime,r("xhr",[t,n,this.startTime,this.endTime,"xhr"],this,a.K7.ajax))}}function T(e,r){e.params.status=r.status;var n=function(e,t){var r=e.responseType;return"json"===r&&null!==t?t:"arraybuffer"===r||"blob"===r||"json"===r?G(e.response):"text"===r||""===r||void 0===r?G(e.responseText):void 0}(r,e.lastSize);if(n&&(e.metrics.rxSize=n),e.sameOrigin){var i=r.getResponseHeader("X-NewRelic-App-Data");i&&((0,w.p)(O.rs,["Ajax/CrossApplicationTracing/Header/Seen"],void 0,a.K7.metrics,t),e.params.cat=i.split(", ").pop())}e.loadCaptureCalled=!0}t.on("new-xhr",i),t.on("open-xhr-start",o),t.on("open-xhr-end",s),t.on("send-xhr-start",c),t.on("xhr-cb-time",d),t.on("xhr-load-added",u),t.on("xhr-load-removed",l),t.on("xhr-resolved",f),t.on("addEventListener-end",h),t.on("removeEventListener-end",p),t.on("fn-end",v),t.on("fetch-before-start",b),t.on("fetch-start",y),t.on("fn-start",m),t.on("fetch-done",R)}(e,this.ee,this.handler,this.dt),this.importAggregator(e)}}function ge(e,t){var r=(0,ie.D)(t),n=e.params||e;n.hostname=r.hostname,n.port=r.port,n.protocol=r.protocol,n.host=r.hostname+":"+r.port,n.pathname=r.pathname,e.parsedOrigin=r,e.sameOrigin=r.sameOrigin}const pe={},me=["pushState","replaceState"];function ve(e){const t=function(e){return(e||B.ee).get("history")}(e);return!g.RI||pe[t.debugId]++||(pe[t.debugId]=1,(0,W.YM)(t).inPlace(window.history,me,"-")),t}var be=i(3738);const{He:ye,bD:Re,d3:xe,Kp:we,TZ:Te,Lc:Ae,uP:Ee,Rz:Se}=be;class _e extends b{static featureName=Te;constructor(e,t=!0){super(e,Te,t);if(!(0,m.V)(this.agentIdentifier))return void this.deregisterDrain();const r=this.ee;let n;ve(r),this.eventsEE=(0,F.u)(r),this.eventsEE.on(Ee,(function(e,t){this.bstStart=(0,S.t)()})),this.eventsEE.on(Ae,(function(e,t){(0,w.p)("bst",[e[0],t,this.bstStart,(0,S.t)()],void 0,a.K7.sessionTrace,r)})),r.on(Se+xe,(function(e){this.time=(0,S.t)(),this.startPath=location.pathname+location.hash})),r.on(Se+we,(function(e){(0,w.p)("bstHist",[location.pathname+location.hash,this.startPath,this.time],void 0,a.K7.sessionTrace,r)}));try{n=new PerformanceObserver((e=>{const t=e.getEntries();(0,w.p)(ye,[t],void 0,a.K7.sessionTrace,r)})),n.observe({type:Re,buffered:!0})}catch(e){}this.importAggregator(e,{resourceObserver:n})}}var Oe=i(2614);class Ne extends b{static featureName=t.TZ;#i;#o;constructor(e,r=!0){let n;super(e,t.TZ,r),this.replayRunning=!1,this.#o=e;try{n=JSON.parse(localStorage.getItem("".concat(Oe.H3,"_").concat(Oe.uh)))}catch(e){}(0,p.SR)(e.agentIdentifier)&&this.ee.on(t.G4.RECORD,(()=>this.#a())),this.#s(n)?(this.#i=n?.sessionReplayMode,this.#c()):this.importAggregator(e),this.ee.on("err",(e=>{this.replayRunning&&(this.errorNoticed=!0,(0,w.p)(t.G4.ERROR_DURING_REPLAY,[e],void 0,this.featureName,this.ee))})),this.ee.on(t.G4.REPLAY_RUNNING,(e=>{this.replayRunning=e}))}#s(e){return e&&(e.sessionReplayMode===Oe.g.FULL||e.sessionReplayMode===Oe.g.ERROR)||(0,p.Aw)(this.agentIdentifier)}#d=!1;async#c(e){if(!this.#d){this.#d=!0;try{const{Recorder:t}=await Promise.all([i.e(891),i.e(222)]).then(i.bind(i,8589));this.recorder??=new t({mode:this.#i,agentIdentifier:this.agentIdentifier,trigger:e,ee:this.ee}),this.recorder.startRecording(),this.abortHandler=this.recorder.stopRecording}catch(e){}this.importAggregator(this.#o,{recorder:this.recorder,errorNoticed:this.errorNoticed})}}#a(){this.featAggregate?this.featAggregate.mode!==Oe.g.FULL&&this.featAggregate.initializeRecording(Oe.g.FULL,!0):(this.#i=Oe.g.FULL,this.#c(t.Qb.API),this.recorder&&this.recorder.parent.mode!==Oe.g.FULL&&(this.recorder.parent.mode=Oe.g.FULL,this.recorder.stopRecording(),this.recorder.startRecording(),this.abortHandler=this.recorder.stopRecording))}}var Ie=i(3333);class Pe extends b{static featureName=Ie.TZ;constructor(e,t=!0){super(e,Ie.TZ,t);const r=[e.init.page_action.enabled,e.init.performance.capture_marks,e.init.performance.capture_measures,e.init.user_actions.enabled];g.RI&&e.init.user_actions.enabled&&(Ie.Zp.forEach((e=>(0,A.sp)(e,(e=>(0,w.p)("ua",[e],void 0,this.featureName,this.ee)),!0))),Ie.qN.forEach((e=>(0,A.sp)(e,(e=>(0,w.p)("ua",[e],void 0,this.featureName,this.ee)))))),r.some((e=>e))?this.importAggregator(e):this.deregisterDrain()}}var je=i(993),Ce=i(3785);class ke extends b{static featureName=je.TZ;constructor(e,t=!0){super(e,je.TZ,t);const r=this.ee;this.ee.on("wrap-logger-end",(function([e]){const{level:t,customAttributes:n}=this;(0,Ce.R)(r,e,n,t)})),this.importAggregator(e)}}new class extends o{constructor(t,r){super(r),g.gm?(this.features={},(0,x.bQ)(this.agentIdentifier,this),this.desiredFeatures=new Set(t.features||[]),this.desiredFeatures.add(R),this.runSoftNavOverSpa=[...this.desiredFeatures].some((e=>e.featureName===a.K7.softNav)),(0,u.j)(this,t,t.loaderType||"agent"),this.run()):(0,e.R)(21)}get config(){return{info:this.info,init:this.init,loader_config:this.loader_config,runtime:this.runtime}}run(){try{const t=d(this.agentIdentifier),r=[...this.desiredFeatures];r.sort(((e,t)=>a.P3[e.featureName]-a.P3[t.featureName])),r.forEach((r=>{if(!t[r.featureName]&&r.featureName!==a.K7.pageViewEvent)return;if(this.runSoftNavOverSpa&&r.featureName===a.K7.spa)return;if(!this.runSoftNavOverSpa&&r.featureName===a.K7.softNav)return;const n=function(e){switch(e){case a.K7.ajax:return[a.K7.jserrors];case a.K7.sessionTrace:return[a.K7.ajax,a.K7.pageViewEvent];case a.K7.sessionReplay:return[a.K7.sessionTrace];case a.K7.pageViewTiming:return[a.K7.pageViewEvent];default:return[]}}(r.featureName).filter((e=>!(e in this.features)));n.length>0&&(0,e.R)(36,{targetFeature:r.featureName,missingDependencies:n}),this.features[r.featureName]=new r(this)}))}catch(t){(0,e.R)(22,t);for(const e in this.features)this.features[e].abortHandler?.();const r=(0,x.Zm)();delete r.initializedAgents[this.agentIdentifier]?.api,delete r.initializedAgents[this.agentIdentifier]?.features,delete this.sharedAggregator;return r.ee.get(this.agentIdentifier).abort(),!1}}}({features:[R,_,_e,Ne,he,N,L,Pe,ke],loaderType:"pro"})})()})();</script> <link rel="profile" href="http://www.w3.org/1999/xhtml/vocab" /> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <meta name="keywords" content="Myosin, II, ATPase" /> <link rel="canonical" href="https://www.tocris.com/pharmacology/myosin" /> <title>Myosin | ATPases | Tocris Bioscience</title> <meta name="description" content="View and buy high purity products active at Myosin II ATPase from Tocris Bioscience." /> <meta http-equiv="content-language" content="en-us" /> <link href="https://www.tocris.com/pharmacology/myosin" rel="alternate" hreflang="x-default" /> <link href="https://www.tocris.com/pharmacology/myosin" rel="alternate" hreflang="en" /> <link href="https://www.tocris.com/cn/pharmacology/myosin" rel="alternate" hreflang="zh-cn" /> <meta name="baidu-site-verification" content="bMqlqGgPRi" /> <script id="json-ld" type="application/ld+json">[{"@context":"http://schema.org","@type":"WebPage","breadcrumb":{"@context":"http://schema.org","@type":"BreadcrumbList","itemListElement":[{"@context":"http://schema.org","@type":"ListItem","position":1,"item":{"@context":"http://schema.org","@type":"Thing","@id":"https://www.tocris.com/","name":"Home"}},{"@context":"http://schema.org","@type":"ListItem","position":2,"item":{"@context":"http://schema.org","@type":"Thing","@id":"https://www.tocris.com/pharmacology","name":"Pharmacology"}},{"@context":"http://schema.org","@type":"ListItem","position":3,"item":{"@context":"http://schema.org","@type":"Thing","@id":"https://www.tocris.com/pharmacology/enzymes","name":"Enzymes"}},{"@context":"http://schema.org","@type":"ListItem","position":4,"item":{"@context":"http://schema.org","@type":"Thing","@id":"https://www.tocris.com/pharmacology/atpases","name":"ATPases"}}]},"potentialaction":{"query":""}}]</script> <meta name="generator" content="Drupal 7 (https://www.drupal.org)" /> <link rel="shortlink" href="https://www.tocris.com/pharmacology/myosin" /> <meta property="og:site_name" content="Tocris Bioscience" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.tocris.com/pharmacology/myosin" /> <meta property="og:title" content="Pharmacology" /> <meta property="og:image" content="https://resources.tocris.com/images/Social/2019TocrisLogoV.png" /> <link type="text/css" rel="stylesheet" href="https://www.tocris.com/sites/tocris.com/files/css/css_gbdeDwx2KR-3alrXD8Yvh_KvMl7rp9fb8nDnlYMc6JE.css" media="all" /> <link type="text/css" rel="stylesheet" href="https://www.tocris.com/sites/tocris.com/files/css/css_ZFPWfTE8WRD_QuXXZ4pXmOP_txiYrSgb2U-wb-M98WU.css" media="all" /> <link type="text/css" rel="stylesheet" href="https://www.tocris.com/sites/tocris.com/files/css/css_E9wOyVBBPLIeq4Al4boCEX0keoOVPHA0RDiCFZgx0Co.css" media="screen" /> <link type="text/css" rel="stylesheet" href="https://www.tocris.com/sites/tocris.com/files/css/css_eTEze5CVY-FBlnpOcPnT07LL13ldh28hUqX2hi45QiA.css" media="all" /> <link type="text/css" rel="stylesheet" href="https://www.tocris.com/sites/tocris.com/files/css/css_jM4nirE4SXt8YNh2L98JC0pdWVR11t8yFIkRbCSSHME.css" media="all" /> <link type="text/css" rel="stylesheet" href="https://resources.tocris.com/bootstrap/bootstrap.min.css" media="all" /> <link type="text/css" rel="stylesheet" href="https://www.tocris.com/sites/tocris.com/files/css/css_oPXAh5zWUMbTd4lSRWCKMwfGfcGDoiwO8Swk6V4T2Qk.css" media="all" />   <script src="https://www.tocris.com/sites/tocris.com/files/js/js_r1OC5xdRG2cR3ewVbCVMpsuSArUnbrxRo0KqbAuY3rM.js"></script> <script src="https://www.tocris.com/sites/tocris.com/files/js/js_sAnmYfqPupk2sidWg7joDvbNo107Utmqwl2alpBSG2s.js"></script> <script src="https://www.tocris.com/sites/tocris.com/files/js/js_Xi06SsSjWo0pijMgsuSP6P2_H0FGlD8xDsWHnzuXEpY.js"></script> <script src="https://resources.tocris.com/bootstrap/bootstrap.min.js"></script> <script src="https://www.tocris.com/sites/tocris.com/files/js/js_Mxv9UFtbr0o94bNhP1D7EsLV0jAny0TnE-BPcXcny98.js"></script> <script src="https://www.tocris.com/sites/tocris.com/files/js/js_L-j9QB-RznEyo-owCFNdF63O71gIMJR9pbCzOMSrUOM.js"></script> <script>var dataLayer = dataLayer || []; dataLayer.push({"email": ""}); dataLayer.push({'PageType': 'ListingPage'}); var productIdList = []; productIdList.push('1852'); productIdList.push('1760'); productIdList.push('1870'); dataLayer.push({'ProductIDList': productIdList});</script> <script>var dataLayer = dataLayer || [] dataLayer.push({"event":"userRole","userRole":"anonymous user"});</script> <script src="https://www.tocris.com/sites/tocris.com/files/js/js_qSLK6sec_HD6cn6dBmvEEuS61rTnxTCFXPJd_HS0nvI.js"></script> <script src="https://www.tocris.com/sites/tocris.com/files/js/js__JuFmti1OZYyBBidIUJvoDOZg81ze1_8XkKpzZ5SPsY.js"></script> <script>jQuery.extend(Drupal.settings, {"basePath":"\/","pathPrefix":"","setHasJsCookie":0,"ajaxPageState":{"theme":"Tocris_2017","theme_token":"EylNAZD5zPpVAaJDBUPVWc6olz516vxrR8FAzKZKCXQ","jquery_version":"2.2","js":{"0":1,"sites\/all\/themes\/bootstrap\/js\/bootstrap.js":1,"public:\/\/google_tag\/language\/google_tag.en.script.js":1,"sites\/tocris.com\/modules\/jquery_update\/replace\/jquery\/2.2\/jquery.min.js":1,"misc\/jquery-extend-3.4.0.js":1,"misc\/jquery-html-prefilter-3.5.0-backport.js":1,"misc\/jquery.once.js":1,"sites\/tocris.com\/modules\/jquery_update\/replace\/ui\/ui\/minified\/jquery.ui.core.min.js":1,"sites\/tocris.com\/modules\/jquery_update\/replace\/ui\/ui\/minified\/jquery.ui.widget.min.js":1,"misc\/drupal.js":1,"sites\/all\/modules\/enterprise-tech\/et_javafunctions\/js\/jquery_cookie.js":1,"sites\/all\/modules\/enterprise-tech\/et_javafunctions\/js\/jQuery_cycle2.js":1,"sites\/all\/modules\/enterprise-tech\/et_javafunctions\/js\/ekko-lightbox.js":1,"sites\/all\/modules\/enterprise-tech\/et_javafunctions\/js\/et-ekko-lightbox.js":1,"sites\/all\/modules\/enterprise-tech\/et_javafunctions\/js\/jquery_hoverintent.js":1,"sites\/all\/modules\/enterprise-tech\/et_javafunctions\/js\/jquery_lazyload.js":1,"sites\/tocris.com\/modules\/jquery_update\/replace\/ui\/ui\/minified\/jquery.ui.position.min.js":1,"misc\/ui\/jquery.ui.position-1.13.0-backport.js":1,"sites\/tocris.com\/modules\/jquery_update\/replace\/ui\/ui\/minified\/jquery.ui.menu.min.js":1,"sites\/tocris.com\/modules\/jquery_update\/replace\/ui\/ui\/minified\/jquery.ui.autocomplete.min.js":1,"sites\/all\/modules\/enterprise-tech\/et_searchbar\/js\/searchbar_autocomplete.js":1,"sites\/tocris.com\/modules\/jquery_update\/replace\/ui\/external\/jquery.cookie.js":1,"sites\/tocris.com\/modules\/jquery_update\/replace\/jquery.form\/4\/jquery.form.min.js":1,"sites\/all\/modules\/enterprise-tech\/et_quickorder_responsive\/js\/et_quickorder_responsive.js":1,"sites\/tocris.com\/modules\/jquery_update\/replace\/ui\/ui\/minified\/jquery.ui.effect.min.js":1,"sites\/tocris.com\/modules\/jquery_update\/replace\/ui\/ui\/minified\/jquery.ui.effect-highlight.min.js":1,"misc\/ajax.js":1,"sites\/tocris.com\/modules\/jquery_update\/js\/jquery_update.js":1,"https:\/\/resources.tocris.com\/bootstrap\/bootstrap.min.js":1,"sites\/all\/modules\/contrib\/fields\/entityreference\/js\/entityreference.js":1,"sites\/all\/modules\/enterprise-tech\/et_internationalization\/js\/et_internationalization.js":1,"sites\/all\/modules\/enterprise-tech\/et_javafunctions\/js\/jQuery_et.js":1,"sites\/all\/modules\/enterprise-tech\/et_top_scroll\/js\/top_scroll.js":1,"sites\/all\/modules\/contrib\/globallink\/js\/globallink_active_submissions.js":1,"sites\/all\/modules\/contrib\/globallink\/js\/globallink_send_translations.js":1,"sites\/all\/modules\/contrib\/globallink\/js\/globallink_field_configuration.js":1,"sites\/all\/modules\/contrib\/globallink\/globallink_entity\/js\/globallink_entity_active_submissions.js":1,"sites\/all\/modules\/contrib\/globallink\/globallink_entity\/js\/globallink_entity_send.js":1,"sites\/all\/modules\/contrib\/globallink\/globallink_menu\/js\/globallink_menu_active_submissions.js":1,"sites\/all\/modules\/contrib\/globallink\/globallink_taxonomy\/js\/globallink_taxonomy_active_submissions.js":1,"sites\/all\/modules\/contrib\/marketo_ma\/js\/marketo_ma.js":1,"sites\/all\/modules\/enterprise-tech\/et_cookie_policy\/js\/et_cookie_policy.js":1,"sites\/all\/modules\/enterprise-tech\/et_search\/json_viewer\/js\/jsonviewer.js":1,"sites\/tocris.com\/modules\/et_pharm_browser\/js\/et_pharm_browser.js":1,"sites\/all\/modules\/enterprise-tech\/et_searchbar\/js\/et_searchbar.js":1,"sites\/all\/themes\/bootstrap\/js\/misc\/_progress.js":1,"sites\/all\/modules\/et_commerce\/et_atc_blocks\/js\/et_atc_cart_summary.js":1,"sites\/all\/modules\/et_commerce\/et_atc_blocks\/js\/et_atc_blocks.js":1,"sites\/all\/modules\/enterprise-tech\/et_combined_seo\/js\/et_combined_seo.js":1,"1":1,"2":1,"sites\/tocris.com\/themes\/Tocris_2017\/js\/tocris.js":1,"sites\/tocris.com\/themes\/Tocris_2017\/js\/et_mobile_theme.js":1,"sites\/tocris.com\/themes\/Tocris_2017\/js\/tocris_menu.js":1,"sites\/tocris.com\/themes\/Tocris_2017\/js\/distributors.js":1,"sites\/all\/themes\/bootstrap\/js\/misc\/ajax.js":1},"css":{"modules\/system\/system.base.css":1,"sites\/all\/modules\/enterprise-tech\/et_javafunctions\/css\/ekko-lightbox.css":1,"misc\/ui\/jquery.ui.core.css":1,"misc\/ui\/jquery.ui.theme.css":1,"misc\/ui\/jquery.ui.menu.css":1,"misc\/ui\/jquery.ui.autocomplete.css":1,"sites\/all\/modules\/enterprise-tech\/et_quickorder_responsive\/css\/et_quickorder_responsive.css":1,"sites\/all\/modules\/enterprise-tech\/et_internationalization\/css\/et_internationalization.css":1,"sites\/all\/modules\/enterprise-tech\/et_product_page_promo\/css\/et_product_page_promo.css":1,"sites\/all\/modules\/enterprise-tech\/et_top_scroll\/css\/top_scroll.css":1,"modules\/field\/theme\/field.css":1,"sites\/all\/modules\/contrib\/globallink\/css\/globallink_active_submissions.css":1,"modules\/node\/node.css":1,"sites\/all\/modules\/contrib\/views\/css\/views.css":1,"sites\/all\/modules\/contrib\/userInterface\/ckeditor\/css\/ckeditor.css":1,"sites\/all\/modules\/contrib\/ctools\/css\/ctools.css":1,"sites\/tocris.com\/modules\/et_pharm_browser\/css\/et_pharm_browser.css":1,"sites\/tocris.com\/themes\/Tocris_2017\/css\/featured_products.css":1,"https:\/\/resources.rndsystems.com\/bootstrap\/drupal-bootstrap.min.css":1,"https:\/\/resources.tocris.com\/bootstrap\/bootstrap.min.css":1,"sites\/tocris.com\/themes\/Tocris_2017\/css\/style.css":1}},"country_name":"United States","et_internationalization":{"social":"Default","distphone":""},"et_searchbar":{"min_chars":3},"et_quickorder_responsive":{"enabled":true,"show_cart":"1","display_price":"0","isDistributor":false},"bootstrap":{"anchorsFix":"0","anchorsSmoothScrolling":"0","formHasError":1,"popoverEnabled":0,"popoverOptions":{"animation":1,"html":0,"placement":"right","selector":"","trigger":"click","triggerAutoclose":1,"title":"","content":"","delay":0,"container":"body"},"tooltipEnabled":0,"tooltipOptions":{"animation":1,"html":0,"placement":"auto left","selector":"","trigger":"hover focus","delay":0,"container":"body"}}});</script> <link rel="apple-touch-icon" sizes="180x180" href="/sites/tocris.com/themes/Tocris_2017/images/favicons/apple-touch-icon.png"> <link rel="icon" type="image/png" href="/sites/tocris.com/themes/Tocris_2017/images/favicons/favicon-32x32.png" sizes="32x32"> <link rel="icon" type="image/png" href="/sites/tocris.com/themes/Tocris_2017/images/favicons/favicon-16x16.png" sizes="16x16"> <link rel="manifest" href="/sites/tocris.com/themes/Tocris_2017/images/favicons/manifest.json"> <link rel="mask-icon" href="/sites/tocris.com/themes/Tocris_2017/images/favicons/safari-pinned-tab.svg" color="#5bbad5"> <link rel="shortcut icon" href="/sites/tocris.com/themes/Tocris_2017/images/favicons/favicon.ico"> <meta name="apple-mobile-web-app-title" content="Tocris Bioscience"> <meta name="application-name" content="Tocris Bioscience"> <meta name="msapplication-config" content="/sites/tocris.com/themes/Tocris_2017/images/favicons/browserconfig.xml"> <meta name="theme-color" content="#ffffff"> </head> <body class="html not-front not-logged-in no-sidebars page-pharmacology page-pharmacology-myosin i18n-en" base-theme="Tocris_2017">  <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-52P87LJ" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>  <div id="skip-link"> <a href="#main-content" class="element-invisible element-focusable">Skip to main content</a> </div> <div class="region region-page-top"> <noscript aria-hidden="true"><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-52P87LJ" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript> </div> <header id="header" role="banner">   <div id="bb_container"> <div id="brands_bar"> <div class="region region-brands-bar"> <section id="block-bt-brands-bar-bt-brands-bar" class="block block-bt-brands-bar clearfix"> <li class="bb_biotechne"><a href="https://www.bio-techne.com" rel="noopener noreferrer" target="_blank" aria-label="Bio-Techne"></a></li><li class="bb_rndsystems"><a href="https://www.rndsystems.com" rel="noopener noreferrer" target="_blank" aria-label="R&D Systems"></a></li><li class="bb_novusbio"><a href="https://www.novusbio.com" rel="noopener noreferrer" target="_blank" aria-label="Novus Biologicals"></a></li><li class="bb_tocris active"><a href="https://www.tocris.com" rel="noopener noreferrer" target="_self" aria-label="Tocris Bioscience"></a></li><li class="bb_proteinsimple"><a href="https://www.bio-techne.com/brands/proteinsimple" rel="noopener noreferrer" target="_blank" aria-label="ProteinSimple"></a></li><li class="bb_biospacific"><a href="https://www.biospacific.com" rel="noopener noreferrer" target="_blank" aria-label="BiosPacific"></a></li><li class="bb_cliniqa"><a href="https://www.cliniqa.com" rel="noopener noreferrer" target="_blank" aria-label="Cliniqa"></a></li><li class="bb_acd"><a href="https://acdbio.com/ " rel="noopener noreferrer" target="_blank" aria-label="ACD"></a></li><li class="bb_rndheme"><a href="https://www.rndheme.com" rel="noopener noreferrer" target="_blank" aria-label="R&D Heme"></a></li> </section> </div> </div> </div> <div id="hd_container"> <div id="logo_block"> <section id="block-logo-block-logo" class="block block-logo-block clearfix"> <a href="/" title="Tocris.com" class="active"></a> </section> </div> <div id="search_bar"> <div class="region region-search-bar"> <section id="block-et-searchbar-et-searchbar-bar" class="block block-et-searchbar clearfix"> <form name="et_searchbar" method="GET" action="/search" class="search_form"><div class="et_searchbar"> <input autocomplete="off" name="keywords" type="text" class="et_searchbar_wide et_searchbar_default" value="" placeholder="Search Cat. No., Product or Target" data-default="" /><input type="submit" value="" class="fp_mag_glass_wideSearch"></div></form> </section> </div> </div> <div id="cart_menu_mobile" class="atc_cart_summary_icon"></div> <div id="account_menu_mobile"></div> <div id="account_menu"> <div class="region region-account-menu"> <section id="block-et-internationalization-country-dropdown" class="block block-et-internationalization clearfix"> <div id="internationalization_country_select"> <div class="internationalization_drop"></div> </div> </section> <section id="block-et-internationalization-sign-in" class="block block-et-internationalization clearfix"> <div id="sign_in"><a href="/user/login" rel="nofollow"><noscript>Account</noscript></a></div> </section> <section id="block-et-atc-blocks-et-atc-cart-summary" class="block block-et-atc-blocks clearfix"> <ul class="menu nav"> <li class="first last leaf active"><a href="/cart" class="active atc_cart_summary_icon"><span class="atc_blocks_items_in_cart">0</span> Items</a></li> </ul> </section> <section id="block-et-cookie-policy-cookie-policy" class="block block-et-cookie-policy clearfix"> <div></div> </section> </div> </div> </div> <div id="mm_container"> <div id="main_menu_mobile"></div> <nav id="main_menu"> <div class="region region-main-menu"> <section id="block-system-main-menu" class="block block-system block-menu clearfix"> <ul class="menu nav"><li class="first expanded active-trail active dropdown"><a href="/products" class="active-trail" id="main-menu-577" data-target="#">Products <span class="caret"></span></a><div class="menu_toggle"></div><ul class="dropdown-menu"><li class="first expanded active-trail active dropdown"><a href="/pharmacology" class="active-trail active" id="main-menu-3526" data-target="#">Pharmacology <span class="caret"></span></a><div class="menu_toggle"></div><ul class="third-level-menu"><li class="first leaf"><a href="/pharmacology/7-tm-receptors" id="main-menu-3966">GPCRs / 7-TM Receptors</a></li> <li class="leaf"><a href="/pharmacology/enzyme-linked-receptors" id="main-menu-4221">Enzyme-Linked Receptors</a></li> <li class="leaf"><a href="/pharmacology/enzymes" id="main-menu-4231">Enzymes</a></li> <li class="leaf"><a href="/pharmacology/ion-channels" id="main-menu-4211">Ion Channels</a></li> <li class="leaf"><a href="/pharmacology/nuclear-receptors" id="main-menu-4216">Nuclear Receptors</a></li> <li class="leaf"><a href="/pharmacology/transporters" id="main-menu-4226">Transporters</a></li> <li class="leaf"><a href="/pharmacology/other-pharmacology" id="main-menu-4236">Other Pharmacology</a></li> <li class="last leaf"><a href="/pharmacology/all-targets/0-9" id="main-menu-6456">All Targets</a></li> </ul></li> <li class="expanded dropdown"><a href="/cell-biology" id="main-menu-3971" data-target="#">Cell Biology <span class="caret"></span></a><div class="menu_toggle"></div><ul class="third-level-menu"><li class="first leaf"><a href="/cell-biology/angiogenesis" id="main-menu-4241">Angiogenesis</a></li> <li class="leaf"><a href="/cell-biology/cell-cycle" id="main-menu-4246">Cell Cycle</a></li> <li class="leaf"><a href="/cell-biology/cell-metabolism" id="main-menu-4251">Cell Metabolism</a></li> <li class="leaf"><a href="/cell-biology/cytoskeleton-and-motor-proteins" id="main-menu-4256">Cytoskeleton & Motor Proteins</a></li> <li class="leaf"><a href="/cell-biology/extracellular-matrix-and-adhesion-molecules" id="main-menu-4261">ECM & Adhesion Molecules</a></li> <li class="leaf"><a href="/cell-biology/epigenetics" id="main-menu-4266">Epigenetics</a></li> <li class="leaf"><a href="/cell-biology/regulated-cell-death" id="main-menu-3981">Regulated Cell Death</a></li> <li class="leaf"><a href="/cell-biology/signal-transduction" id="main-menu-4271">Signal Transduction</a></li> <li class="last leaf"><a href="/cell-biology/stem-cells" id="main-menu-4276">Stem Cells</a></li> </ul></li> <li class="expanded dropdown"><a href="/product-type" id="main-menu-3986" data-target="#">Product Type <span class="caret"></span></a><div class="menu_toggle"></div><ul class="third-level-menu"><li class="first leaf"><a href="/product-type/all-products" id="main-menu-3991">All Products</a></li> <li class="leaf"><a href="/product-type/small-molecules" id="main-menu-4281">Small Molecules</a></li> <li class="leaf"><a href="/product-type/peptides" id="main-menu-4286">Peptides</a></li> <li class="leaf"><a href="/product-type/chemogenetics" id="main-menu-4311">Chemogenetics </a></li> <li class="leaf"><a href="/product-type/controlled-substances" id="main-menu-4291">Controlled Substances</a></li> <li class="leaf"><a href="/product-type/tocriscreen-compound-libraries" id="main-menu-4366">Compound Libraries</a></li> <li class="leaf"><a href="/product-type/fluorescence-imaging" id="main-menu-4321">Fluorescence Imaging</a></li> <li class="leaf"><a href="/product-type/gmp-ancillary-material-grade-small-molecules" id="main-menu-14146">GMP & Ancillary Material Grade Small Molecules</a></li> <li class="leaf"><a href="/product-type/optopharmacology" id="main-menu-12761">Optopharmacology</a></li> <li class="leaf"><a href="/product-type/targeted-protein-degradation" class="menu-item-updated" id="main-menu-13196">PROTACs & Targeted Protein Degradation</a></li> <li class="leaf"><a href="/product-type/reagents" id="main-menu-4331">Reagents</a></li> <li class="leaf"><a href="/product-type/stapled-peptides" id="main-menu-15251">Stapled Peptides</a></li> <li class="last leaf"><a href="/product-type/toxins" id="main-menu-4296">Toxins</a></li> </ul></li> <li class="expanded dropdown"><a href="/research-area" id="main-menu-7406" data-target="#">Research Area <span class="caret"></span></a><div class="menu_toggle"></div><ul class="third-level-menu"><li class="first leaf"><a href="/research-area/cancer-research" class="menu-item-updated" id="main-menu-7411">Cancer</a></li> <li class="leaf"><a href="/research-area/cardiovascular-system-research" id="main-menu-7416">Cardiovascular System</a></li> <li class="leaf"><a href="/research-area/cell-and-gene-therapy" id="main-menu-15266">Cell and Gene Therapy</a></li> <li class="leaf"><a href="/research-area/covid-19-research" id="main-menu-15306">COVID-19 Research</a></li> <li class="leaf"><a href="/research-area/endocrinology-research" id="main-menu-7421">Endocrinology</a></li> <li class="leaf"><a href="/research-area/immunology-research" id="main-menu-7426">Immunology</a></li> <li class="leaf"><a href="/research-area/infectious-disease" id="main-menu-15296">Infectious Disease</a></li> <li class="leaf"><a href="/research-area/neuroscience-research" id="main-menu-7431">Neuroscience</a></li> <li class="leaf"><a href="/research-area/pain-and-inflammation-research" id="main-menu-7436">Pain & Inflammation</a></li> <li class="last leaf"><a href="/research-area/respiratory-system-research" id="main-menu-7441">Respiratory System</a></li> </ul></li> <li class="last leaf"><a href="/product-type/new-products" id="main-menu-3996">New Products</a></li> </ul></li> <li class="expanded dropdown"><a href="/support" id="main-menu-578" data-target="#">Support <span class="caret"></span></a><div class="menu_toggle"></div><ul class="dropdown-menu short"><li class="first leaf"><a href="/support/customer-support" id="main-menu-13886">Customer Support</a></li> <li class="leaf"><a href="/support/technical-support" id="main-menu-13881">Technical Support</a></li> <li class="leaf"><a href="/support/contact-us" id="main-menu-7466">Contact Us</a></li> <li class="leaf"><a href="/distributors" id="main-menu-7471">Distributors</a></li> <li class="leaf"><a href="/support/leave-feedback" rel="nofollow" id="main-menu-8151">Leave Feedback</a></li> <li class="leaf"><a href="/scholarship" id="main-menu-13181">Scholarship Program</a></li> <li class="leaf"><a href="/reviews" rel="nofollow" id="main-menu-9596">Submit a Review</a></li> <li class="leaf"><a href="/support/promotions" id="main-menu-13351">Promotions</a></li> <li class="leaf"><a href="/support/bulk-quantities-form" rel="nofollow" id="main-menu-9466">Bulk Quantity Discounts</a></li> <li class="leaf"><a href="/support/gmp-compound-inquiry" rel="nofollow" id="main-menu-13201">GMP Compound Register Interest</a></li> <li class="last leaf"><a href="/support/screening-inquiry" id="main-menu-15291">Screening Inquiry</a></li> </ul></li> <li class="expanded dropdown"><a href="/resources" id="main-menu-579" data-target="#">Resources <span class="caret"></span></a><div class="menu_toggle"></div><ul class="dropdown-menu short"><li class="first leaf"><a href="/signaling-pathways" title="Signaling Pathways" id="main-menu-7341">Signaling Pathways</a></li> <li class="leaf"><a href="/resources/peptide-nomenclature-guide" id="main-menu-13811">Peptide Nomenclature Guide</a></li> <li class="leaf"><a href="/resources/pharmacological-glossary" id="main-menu-13816">Pharmacological Glossary</a></li> <li class="leaf"><a href="/resources/useful-abbreviations" id="main-menu-13821">Useful Abbreviations</a></li> <li class="leaf"><a href="/resources/dilution-calculator" id="main-menu-13826">Dilution Calculator</a></li> <li class="leaf"><a href="/resources/molarity-calculator" id="main-menu-13831">Molarity Calculator</a></li> <li class="leaf"><a href="/resources/reconstitution-calculator" id="main-menu-13836">Reconstitution Calculator</a></li> <li class="leaf"><a href="/resources/protocols" id="main-menu-13186">Protocols</a></li> <li class="leaf"><a href="/resources/tocris-blog" id="main-menu-12776">Tocris Blog</a></li> <li class="leaf"><a href="/resources/webinars-and-videos" id="main-menu-13136">Webinars & Videos</a></li> <li class="last leaf"><a href="/resources/spectral-viewer" id="main-menu-14186">Spectra Viewer</a></li> </ul></li> <li class="expanded dropdown"><a href="/services" id="main-menu-13171" data-target="#">Services <span class="caret"></span></a><div class="menu_toggle"></div><ul class="dropdown-menu short"><li class="first leaf"><a href="/services/custom-synthesis" id="main-menu-13781">Custom Synthesis</a></li> <li class="leaf"><a href="/services/chemical-analysis" id="main-menu-13786">Chemical Analysis</a></li> <li class="leaf"><a href="/services/chemical-sourcing" id="main-menu-13791">Chemical Sourcing</a></li> <li class="leaf"><a href="/services/facilities" id="main-menu-13796">Facilities</a></li> <li class="leaf"><a href="/services/expertise" id="main-menu-13801">Expertise</a></li> <li class="leaf"><a href="/services/why-choose-tocris" id="main-menu-13806">Why Choose Tocris?</a></li> <li class="leaf"><a href="/services/request-quote" id="main-menu-15156">Request Quote</a></li> <li class="leaf"><a href="/about-tocris/tocriscreen-pro-custom-compound-library-service" id="main-menu-16551">Custom Compound Library Service</a></li> <li class="leaf"><a href="/services/custom-degrader-services" id="main-menu-15101">Custom Degrader Services</a></li> <li class="last leaf"><a href="/protac-panel-builder" id="main-menu-15406">PROTAC庐 Panel Builder</a></li> </ul></li> <li class="expanded dropdown"><a href="/literature" id="main-menu-7451" data-target="#">Literature <span class="caret"></span></a><div class="menu_toggle"></div><ul class="dropdown-menu short"><li class="first leaf"><a href="/literature/life-science-posters" id="main-menu-6431">Life Science Posters</a></li> <li class="leaf"><a href="/literature/scientific-posters" id="main-menu-15146">Scientific Meeting Posters</a></li> <li class="leaf"><a href="/literature/product-guides" id="main-menu-6441">Product Guides & Listings</a></li> <li class="leaf"><a href="/literature/research-bulletins" id="main-menu-6446">Research Bulletins</a></li> <li class="leaf"><a href="/literature/scientific-reviews" id="main-menu-6436">Scientific Reviews</a></li> <li class="leaf"><a href="/literature/signup" rel="nofollow" id="main-menu-9306">Sign Up for E-Alerts</a></li> <li class="last leaf"><a href="/literature/literature-request" rel="nofollow" id="main-menu-9311">Request Literature</a></li> </ul></li> <li class="expanded dropdown"><a href="/about-tocris" id="main-menu-14011" data-target="#">About Tocris <span class="caret"></span></a><div class="menu_toggle"></div><ul class="dropdown-menu short"><li class="first leaf"><a href="/about-tocris/your-supplier-of-choice" id="main-menu-14131">Your Supplier of Choice</a></li> <li class="leaf"><a href="/about-tocris/tocris-history" id="main-menu-13856">Tocris History</a></li> <li class="leaf"><a href="/about-tocris/tocris-in-the-news" id="main-menu-13851">Tocris in the News</a></li> <li class="leaf"><a href="/about-tocris/tocris-events" id="main-menu-13871">Events & Conferences</a></li> <li class="leaf"><a href="/about-tocris/licensing" id="main-menu-13866">Licensing</a></li> <li class="leaf"><a href="/about-tocris/our-ethos" id="main-menu-13861">Our Ethos</a></li> <li class="leaf"><a href="/about-tocris/environment" id="main-menu-13876">Environment</a></li> <li class="last leaf"><a href="/about-tocris/careers-at-tocris" id="main-menu-13846">Careers</a></li> </ul></li> <li class="last leaf"><a href="/support/contact-us" id="main-menu-7501">Contact Us</a></li> </ul> </section> </div> </nav> </div> </header> <div class="breadcrumbs_wrapper"> <div class="breadcrumbs_container"> <div class="breadcrumb"><a href="/">Home</a> <span class="breadcrumb_separator">/</span> <a href="/pharmacology">Pharmacology</a> <span class="breadcrumb_separator">/</span> <a href="/pharmacology/enzymes">Enzymes</a> <span class="breadcrumb_separator">/</span> <a href="/pharmacology/atpases">ATPases</a> <span class="breadcrumb_separator">/</span> Myosin</div> </div> </div> <div class="main-container container"> <div class="row"> <a id="main-content"></a> <div class="region region-content"> <section id="block-system-main" class="block block-system clearfix"> <div class="col-xs-12 col-sm-8 col-md-9 col-lg-9 col-xl-9 et_pharm_browser_wrapper"> <h1>Myosin</h1> <p><strong>Myosins</strong> are a large family of motor proteins that share the common features of ATP hydrolysis (ATPase enzyme activity), actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells, almost all eukaryotic cells are now known to contain myosins.</p> <div class="tabbed_content"> <div class="tab_menu"> <div class="tab tab_1 tab_open" data-tab="1" data-tabname="products" id="pharm_tabs_products"> <span>Products</span></div> <div class="tab tab_2" data-tab="2" data-tabname="background" id="pharm_tabs_background"><span>Background</span> </div> <div class="tab tab_6" data-tab="6" data-tabname="gene" id="pharm_tabs_gene"> <span>Gene Data</span></div> </div> <div class="tab_content tab_1 tab_open" data-tab="1"> <div class="pharm_products"><table class="pharm_prod_table table table-condensed"> <tr> <th colspan="2"><h3><a href="/pharmacology/myosin/inhibitors" title="View all Myosin Inhibitor products">Myosin Inhibitors</a></h3></th> </tr> <tr> <th>Cat. No.</th> <th>Product Name / Activity</th> </tr> <tr> <td>1852</td> <td><a href="/products/s-blebbistatin_1852" title="View price & availability information for (S)-(-)-Blebbistatin">(<em>S</em>)-(-)-Blebbistatin</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Selective inhibitor of myosin II ATPase activity. Active enantiomer of <a href='/products/dl-blebbistatin_1760'>(卤)-blebbistatin</a> (Cat. No. 1760)</td> </tr> <tr> <td>1760</td> <td><a href="/products/dl-blebbistatin_1760" title="View price & availability information for (卤)-Blebbistatin">(卤)-Blebbistatin</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Selective inhibitor of myosin II ATPase activity</td> </tr> <tr> <td>1870</td> <td><a href="/products/bts_1870" title="View price & availability information for BTS">BTS</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Selective inhibitor of skeletal muscle myosin II ATPase activity</td> </tr></table></div> <div class="pharm_rel_cats"><h3>Related Targets</h3><ul class="tile_column_1"><li><a href="/cell-biology/actin" title="Browse products for Actin">Actin</a></li><li><a href="/pharmacology/kinesin" title="Browse products for Kinesin">Kinesin</a></li></ul><ul class="tile_column_2"><li><a href="/cell-biology/microtubules" title="Browse products for Microtubules">Microtubules</a></li><li><a href="/pharmacology/myosin-light-chain-kinases" title="Browse products for Myosin Light Chain Kinases">Myosin Light Chain Kinases</a></li></ul></div> </div> <div class="tab_content tab_2" data-tab="2"> <p><strong>Myosins</strong> are a large family of motor proteins that share the common features of ATP hydrolysis (ATPase enzyme activity), actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name), almost all eukaryotic cells are now known to contain myosins.</p><p>Structurally, mysoins contain a 'head' domain that binds to <a href='/cell-biology/actin' title='Browse products for actin'>actin</a> filaments (microfilaments) and is the site of ATP hydrolysis. The 'tail' domain interacts with cargo molecules, and the 'neck' acts as a linker between the head and tail and is the site of regulatory myosin light chain binding.</p> <p>There are 17 myosin families and the most well characterized is myosin II. Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a contractile force. It is regulated by phosphorylation via <a href='/pharmacology/myosin-light-chain-kinases' title='Browse products for myosin light chain kinase'>Myosin Light Chain Kinase (MLCK)</a> and by intracellular Ca<sup>2+</sup> concentrations.</p><h3>External sources of pharmacological information for Myosin : </h3><ul class="tile_column_1"><li><a href="https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.13877" target="_blank" rel="nofollow">BJP Guide</a></li></ul><ul class="tile_column_2"></ul> </div> <div class="tab_content tab_3" data-tab="3"> </div> <div class="tab_content tab_4" data-tab="4"> </div> <div class="tab_content tab_5" data-tab="5"> </div> <div class="tab_content tab_6" data-tab="6"> <H3>Myosin Gene Data</H3> <table class="table table-responsive"> <tr> <th style='width:21%' title='Gene'> Gene </th> <th style='width:13%' title='Species'> Species </th> <th style='width:16%' title='The official gene symbol that has been approved by the HGNC'> Gene Symbol </th> <th style='width:25%' title='A unique identifier for a gene sequence record from the Reference Sequence database'> Gene Accession No. </th> <th style='width:25%' title='A unique identifier for a protein sequence record from the UniProt Protein Knowledgebase'> Protein Accession No. </th> </tr> <tr> <td style='width:21%' class='pb_bld' rowspan='3'> Myosin IA </td> <td style='width:13%' class='pb_bld'> Human </td> <td style='width:16%'> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7595' target='_blank'>MYO1A</a> </td> <td style='width:25%'> NM_005379 </td> <td style='width:25%'> Q9UBC5 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=29029' target='_blank'>Myo1a</a> </td> <td> NM_001081219 </td> <td> O88329 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=3135' target='_blank'>Myo1a</a> </td> <td> XM_238479 </td> <td> Q62774 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin IB </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7596' target='_blank'>MYO1B</a> </td> <td> NM_012223 </td> <td> O43795 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=29049' target='_blank'>Myo1b</a> </td> <td> NM_010863 </td> <td> P46735 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=70994' target='_blank'>Myo1b</a> </td> <td> NM_053986 </td> <td> Q05096 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin IC </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7597' target='_blank'>MYO1C</a> </td> <td> NM_033375 </td> <td> O00159 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=27478' target='_blank'>Myo1c</a> </td> <td> NM_001080774 </td> <td> Q9WTI7 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=620443' target='_blank'>Myo1c</a> </td> <td> NM_023092 </td> <td> Q63355 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin ID </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7598' target='_blank'>MYO1D</a> </td> <td> NM_015194 </td> <td> O94832 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=29025' target='_blank'>Myo1d</a> </td> <td> NM_177390 </td> <td> Q5SYD0 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=621321' target='_blank'>Myo1d</a> </td> <td> NM_012983 </td> <td> Q63357 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin IE </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7599' target='_blank'>MYO1E</a> </td> <td> NM_004998 </td> <td> Q12965 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=27487' target='_blank'>Myo1e</a> </td> <td> NM_181072 </td> <td> NP_851417 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=3144' target='_blank'>Myo1e</a> </td> <td> NM_173101 </td> <td> Q63356 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin IF </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7600' target='_blank'>MYO1F</a> </td> <td> NM_012335 </td> <td> O00160 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=29008' target='_blank'>Myo1f</a> </td> <td> NM_053214 </td> <td> P70248 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1309750' target='_blank'>Myo1f</a> </td> <td> NM_001108076 </td> <td> XP_234942 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin IG </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13880' target='_blank'>MYO1G</a> </td> <td> NM_033054 </td> <td> B0I1T2 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=80353' target='_blank'>Myo1g</a> </td> <td> NM_178440 </td> <td> Q5SUA5 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1306016' target='_blank'>Myo1g</a> </td> <td> NM_001134843 </td> <td> Q5M810 </td> </tr> <tr> <td class='pb_bld' rowspan='2'> Myosin IH </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13879' target='_blank'>MYO1H</a> </td> <td> NM_173597 </td> <td> Q8N1T3 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=80354' target='_blank'>Myo1h</a> </td> <td> AK014505 </td> <td> Q9D6A1 </td> </tr> <tr> <td class='pb_bld' rowspan='2'> Myosin IIIA </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7601' target='_blank'>MYO3A</a> </td> <td> NM_017433 </td> <td> Q8NEV4 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=81099' target='_blank'>Myo3a</a> </td> <td> NM_148413 </td> <td> Q8K3H5 </td> </tr> <tr> <td class='pb_bld' rowspan='2'> Myosin IIIB </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15576' target='_blank'>MYO3B</a> </td> <td> NM_001083615 </td> <td> Q96N94 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=91114' target='_blank'>Myo3b</a> </td> <td> NM_177376 </td> <td> Q1EG27 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin VA </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7602' target='_blank'>MYO5A</a> </td> <td> NM_000259 </td> <td> Q9Y4I1 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=26578' target='_blank'>Myo5a</a> </td> <td> NM_010864 </td> <td> Q99104 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=3143' target='_blank'>Myo5a</a> </td> <td> NM_022178 </td> <td> Q9QYF3 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin VB </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7603' target='_blank'>MYO5B</a> </td> <td> NM_001080467 </td> <td> Q9ULV0 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=27463' target='_blank'>Myo5b</a> </td> <td> NM_201600 </td> <td> P21271 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=621347' target='_blank'>Myo5b</a> </td> <td> NM_017083 </td> <td> P70569 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin VC </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7604' target='_blank'>MYO5C</a> </td> <td> NM_018728 </td> <td> Q9NQX4 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=83721' target='_blank'>Myo5c</a> </td> <td> NM_001081322 </td> <td> NP_001074791 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1309994' target='_blank'>Myo5c</a> </td> <td> NM_001108167 </td> <td> XP_236411 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin VI </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7605' target='_blank'>MYO6</a> </td> <td> NM_004999 </td> <td> Q9UM54 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=25046' target='_blank'>Myo6</a> </td> <td> NM_001039546 </td> <td> Q64331 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1560646' target='_blank'>Myo6</a> </td> <td> XM_236444 </td> <td> XP_236444 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin VIIA </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7606' target='_blank'>MYO7A</a> </td> <td> NM_001127179 </td> <td> Q13402 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=24643' target='_blank'>Myo7a</a> </td> <td> NM_008663 </td> <td> P97479 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=628830' target='_blank'>Myo7a</a> </td> <td> NM_153473 </td> <td> Q8CJE3 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin VIIB </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7607' target='_blank'>MYO7B</a> </td> <td> XM_291001 </td> <td> Q6PIF6 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=29006' target='_blank'>Myo7b</a> </td> <td> NM_032394 </td> <td> Q99MZ6 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1561153' target='_blank'>Myo7b</a> </td> <td> XM_574117 </td> <td> XP_574117 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin IXA </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7608' target='_blank'>MYO9A</a> </td> <td> NM_006901 </td> <td> Q9NUY2 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=29032' target='_blank'>Myo9a</a> </td> <td> AK029836 </td> <td> Q8C170 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=621395' target='_blank'>Myo9a</a> </td> <td> NM_134335 </td> <td> Q9Z1N3 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin IXB </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7609' target='_blank'>MYO9B</a> </td> <td> NM_001130065 </td> <td> Q13459 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=27490' target='_blank'>Myo9b</a> </td> <td> NM_001142322 </td> <td> Q9QY06 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=3146' target='_blank'>Myo9b</a> </td> <td> NM_012984 </td> <td> Q4W1H4 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin X </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7593' target='_blank'>MYO10</a> </td> <td> NM_012334 </td> <td> Q9HD67 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=29013' target='_blank'>Myo10</a> </td> <td> NM_019472 </td> <td> NP_062345 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1307193' target='_blank'>Myo10</a> </td> <td> NM_001107657 </td> <td> XP_226874 </td> </tr> <tr> <td class='pb_bld' rowspan='2'> Myosin XVA </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7594' target='_blank'>MYO15A</a> </td> <td> NM_016239 </td> <td> Q9UKN7 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=36272' target='_blank'>Myo15</a> </td> <td> NM_010862 </td> <td> Q9QZZ4 </td> </tr> <tr> <td class='pb_bld' rowspan='2'> Myosin XVB </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14083' target='_blank'>MYO15B</a> </td> <td> NR_003587 </td> <td> Q96JP2 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=97906' target='_blank'>Myo15b</a> </td> <td> AK173262 </td> <td> Q69ZA4 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin XVI </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29822' target='_blank'>MYO16</a> </td> <td> NM_015011 </td> <td> Q9Y6X6 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=98323' target='_blank'>Myo16</a> </td> <td> NM_001081397 </td> <td> Q5DU14 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=621561' target='_blank'>Myo16</a> </td> <td> NM_138893 </td> <td> Q9ERC1 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin XVIIIA </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:31104' target='_blank'>MYO18A</a> </td> <td> NM_078471 </td> <td> Q92614 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=91432' target='_blank'>Myo18a</a> </td> <td> NM_011586 </td> <td> Q9JMH9 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1311007' target='_blank'>Myo18a</a> </td> <td> XM_213551 </td> <td> - </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin XVIIIB </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18150' target='_blank'>MYO18B</a> </td> <td> NM_032608 </td> <td> Q8IUG5 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=58356' target='_blank'>Myo18b</a> </td> <td> BC145218 </td> <td> B7ZNF7 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1594542' target='_blank'>Myo18b</a> </td> <td> XM_239684 </td> <td> XP_239684 </td> </tr> <tr> <td class='pb_bld' rowspan='2'> Myosin XIX </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:26234' target='_blank'>MYO19</a> </td> <td> NM_025109 </td> <td> Q96H55 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=50176' target='_blank'>Myo19</a> </td> <td> BC060115 </td> <td> Q5SV80 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin Heavy Chain I </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7567' target='_blank'>MYH1</a> </td> <td> NM_005963 </td> <td> P12882 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=41063' target='_blank'>Myh1</a> </td> <td> NM_030679 </td> <td> Q5SX40 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=735061' target='_blank'>Myh1</a> </td> <td> NM_001135158 </td> <td> Q0GC39 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin Heavy Chain II </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7572' target='_blank'>MYH2</a> </td> <td> NM_017534 </td> <td> Q9UKX2 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=41062' target='_blank'>Myh2</a> </td> <td> NM_001039545 </td> <td> NP_001034634 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=620354' target='_blank'>Myh2</a> </td> <td> NM_001135157 </td> <td> Q0GC40 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin Heavy Chain III </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7573' target='_blank'>MYH3</a> </td> <td> NM_002470 </td> <td> P11055 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=41061' target='_blank'>Myh3</a> </td> <td> NM_001099635 </td> <td> P13541 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=3138' target='_blank'>Myh3</a> </td> <td> NM_012604 </td> <td> P12847 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin Heavy Chain IV </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7574' target='_blank'>MYH4</a> </td> <td> NM_017533 </td> <td> Q9Y623 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=41065' target='_blank'>Myh4</a> </td> <td> NM_010855 </td> <td> Q5SX39 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=3139' target='_blank'>Myh4</a> </td> <td> NM_019325 </td> <td> Q63350 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin Heavy Chain VI </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7576' target='_blank'>MYH6</a> </td> <td> NM_002471 </td> <td> P13533 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=11762' target='_blank'>Myh6</a> </td> <td> NM_010856 </td> <td> Q02566 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=62029' target='_blank'>Myh6</a> </td> <td> NM_017239 </td> <td> P02563 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin Heavy Chain VII </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7577' target='_blank'>MYH7</a> </td> <td> NM_000257 </td> <td> Q9UMM8 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=78785' target='_blank'>Myh7</a> </td> <td> NM_080728 </td> <td> Q91Z83 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=62030' target='_blank'>Myh7</a> </td> <td> NM_017240 </td> <td> P02564 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin Heavy Chain VIIB </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15906' target='_blank'>MYH7B</a> </td> <td> NM_020884 </td> <td> A7E2Y1 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=309118' target='_blank'>Myo7b</a> </td> <td> NM_001085378 </td> <td> A2AQP0 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1307994' target='_blank'>Myo7b</a> </td> <td> NM_001107794 </td> <td> XP_230774 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin Heavy Chain VIII </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7578' target='_blank'>MYH8</a> </td> <td> NM_002472 </td> <td> P13535 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=41064' target='_blank'>Myh8</a> </td> <td> NM_177369 </td> <td> P13542 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=620356' target='_blank'>Myh8</a> </td> <td> XM_001080186 </td> <td> P04462 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin Heavy Chain IX </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7579' target='_blank'>MYH9</a> </td> <td> NM_002473 </td> <td> P35579 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=29014' target='_blank'>Myh9</a> </td> <td> NM_022410 </td> <td> Q8VDD5 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=3140' target='_blank'>Myh9</a> </td> <td> NM_013194 </td> <td> Q62812 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin Heavy Chain X </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7568' target='_blank'>MYH10</a> </td> <td> NM_005964 </td> <td> P35580 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=63151' target='_blank'>Myh10</a> </td> <td> NM_175260 </td> <td> Q61879 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=71000' target='_blank'>Myh10</a> </td> <td> NM_031520 </td> <td> Q62706 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin Heavy Chain XI </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7569' target='_blank'>MYH11</a> </td> <td> NM_001040113 </td> <td> P35749 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=18583' target='_blank'>Myh11</a> </td> <td> NM_013607 </td> <td> O08638 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=3136' target='_blank'>Myh11</a> </td> <td> XM_001053321 </td> <td> Q63862 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin Heavy Chain XIII </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7571' target='_blank'>MYH13</a> </td> <td> NM_003802 </td> <td> Q9UKX3 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=41123' target='_blank'>Myh13</a> </td> <td> NM_001081250 </td> <td> NP_001074719 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=3137' target='_blank'>Myh13</a> </td> <td> XM_001078857 </td> <td> Q9Z2B7 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin Heavy Chain XIV </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23212' target='_blank'>MYH14</a> </td> <td> NM_024729 </td> <td> Q9H882 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=55940' target='_blank'>Myh14</a> </td> <td> NM_028021 </td> <td> Q6URW6 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1306821' target='_blank'>Myh14</a> </td> <td> NM_001100690 </td> <td> Q9EPH4 </td> </tr> <tr> <td class='pb_bld' rowspan='2'> Myosin Heavy Chain XV </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:31073' target='_blank'>MYH15</a> </td> <td> XM_036988 </td> <td> Q9Y2K3 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=193096' target='_blank'>Myh15</a> </td> <td> XM_992311 </td> <td> XP_997405 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin Light Chain I </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7582' target='_blank'>MYL1</a> </td> <td> NM_079420 </td> <td> P06741 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=11786' target='_blank'>Myl1</a> </td> <td> NM_021285 </td> <td> P05977 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1598796' target='_blank'>Myl1</a> </td> <td> NM_001077656 </td> <td> P02600 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin Light Chain II </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7583' target='_blank'>MYL2</a> </td> <td> NM_000432 </td> <td> P10916 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=11789' target='_blank'>Myl2</a> </td> <td> NM_010861 </td> <td> P51667 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1564245' target='_blank'>Myl2</a> </td> <td> NM_001035252 </td> <td> P08733 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin Light Chain III </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7584' target='_blank'>MYL3</a> </td> <td> NM_000258 </td> <td> P08590 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=11785' target='_blank'>Myl3</a> </td> <td> NM_010859 </td> <td> P09542 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=3142' target='_blank'>Myl3</a> </td> <td> NM_012606 </td> <td> P16409 </td> </tr> <tr> <td class='pb_bld' rowspan='2'> Myosin Light Chain IV </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7585' target='_blank'>MYL4</a> </td> <td> NM_001002841 </td> <td> P12829 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=11784' target='_blank'>Myl4</a> </td> <td> NM_010858 </td> <td> P09541 </td> </tr> <tr> <td class='pb_bld'> Myosin Light Chain V </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7586' target='_blank'>MYl5</a> </td> <td> NM_002477 </td> <td> Q02045 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin Light Chain VI </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7587' target='_blank'>MYL6</a> </td> <td> NM_021019 </td> <td> P60660 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=31343' target='_blank'>Myl6</a> </td> <td> NM_010860 </td> <td> Q60605 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1589019' target='_blank'>Myl6</a> </td> <td> NM_001109484 </td> <td> XP_001070810 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin Light Chain VIB </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29823' target='_blank'>MYL6B</a> </td> <td> NM_002475 </td> <td> P14649 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=54519' target='_blank'>Myl6b</a> </td> <td> NM_172259 </td> <td> Q8CI43 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1589003' target='_blank'>Myl6b</a> </td> <td> NM_001109486 </td> <td> XP_001065619 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin Light Chain VII </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21719' target='_blank'>MYL7</a> </td> <td> NM_021223 </td> <td> Q01449 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=28668' target='_blank'>Myl7</a> </td> <td> NM_022879 </td> <td> Q9QVP4 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1308262' target='_blank'>Myl7</a> </td> <td> NM_001106017 </td> <td> XP_214074 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Myosin Light Chain IX </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15754' target='_blank'>MYL9</a> </td> <td> NM_006097 </td> <td> P24844 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/javawi2/servlet/WIFetch?page=markerDetail&key=66355' target='_blank'>Myl9</a> </td> <td> NM_172118 </td> <td> Q9CQ19 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1311235' target='_blank'>Myl9</a> </td> <td> NM_001100885 </td> <td> Q64122 </td> </tr> <tr> <td class='pb_bld'> Myosin Light Chain X </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29825' target='_blank'>MYL10</a> </td> <td> NM_138403 </td> <td> BC002778 </td> </tr> </table> </div> </div> </div> <div id="sidebar" class="col-xs-12 col-sm-4 col-md-3 col-lg-3 col-xl-3"> <div class="resources_sidebar_container"> <div class="fp_four_box"> <div class="fp_box_wrapper"><h3>Featured New Products</h3> <div class="fp_featured_product"><a href="/products/vu-0542270_8151">8151 | VU 0542270</a><br /> Selective inhibitor of K<sub>ir</sub>6.1 K<sub>ATP</sub> channels</div> <div class="fp_featured_product"><a href="/products/rna-imaging-probe-1c_8813">8813 | RNA Imaging Probe 1c</a><br /> Fluorogenic RNA imaging probe</div> <div class="fp_featured_product"><a href="/products/lsn-3318839_7959">7959 | LSN 3318839</a><br /> Glucagon-like peptide-1 receptor <br />(GLP1-R) positive allosteric modulator</div> <div class="fp_featured_product"><a href="/products/chir-99021-in-solution_8170">8170 | CHIR 99021 in solution</a><br /> Sterile-filtered 10 mM solution of CHIR 99021 pre-dissolved in DMSO</div> <div class="fp_featured_product"><a href="/products/bi-3231_8039">8039 | BI 3231</a><br /> Potent and selective hydroxysteroid 17尾 dehydrogenase 13 (HSD17B13) inhibitor</div> </div> </div> </div> <div class="distributor_region"></div> </div> </section> <section id="block-block-16" class="block block-block clearfix">  <div class="embeddedServiceInvitation" id="snapins_invite" aria-live="assertive" role="dialog" aria-atomic="true" style="display: none;"> <div class="embeddedServiceInvitationHeader" aria-labelledby="snapins_titletext" aria-describedby="snapins_bodytext" style="height:48px;"> <img id="embeddedServiceAvatar" /> <span class="embeddedServiceTitleText" id="snapins_titletext">Need help?</span> <button type="button" id="closeInvite" class="embeddedServiceCloseIcon" aria-label="Exit invitation">×</button> </div> <div class="embeddedServiceInvitationBody"> <p id="snapins_bodytext">How can we help you?</p> </div> <div class="embeddedServiceInvitationFooter" aria-describedby="snapins_bodytext"> <button type="button" class="embeddedServiceActionButton" id="rejectInvite">Close</button> <button type="button" class="embeddedServiceActionButton" id="acceptInvite">Start Chat</button> </div> </div> </section> </div> </div> </div> <footer id="footer_wrapper" class="container-fluid"> <div id="footer_wrapper_container" class="row"> <div id="footer" class="container"> <div id="footer_container" class="row"> <nav class="footer_column footer_column_1 col-xs-12 col-sm-3"> <div class="region region-footer-column-1"> <section id="block-menu-menu-corporate-menu" class="block block-menu clearfix"> <h6 class="block-title">Corporate</h6> <ul class="menu nav"><li class="first leaf"><a href="/about-tocris" id="menu-corporate-menu-14021">About Us</a></li> <li class="leaf"><a href="/about-tocris/careers-at-tocris" id="menu-corporate-menu-14026">Careers</a></li> <li class="leaf"><a href="/about-tocris/tocris-events" id="menu-corporate-menu-14031">Events</a></li> <li class="leaf"><a href="/support/terms-and-conditions-of-sale" id="menu-corporate-menu-591">Terms & Conditions</a></li> <li class="last leaf"><a href="/about-tocris/tocris-in-the-news" id="menu-corporate-menu-594">Tocris in the News</a></li> </ul> </section> </div> </nav> <nav class="footer_column footer_column_2 col-xs-12 col-sm-3"> <div class="region region-footer-column-2"> <section id="block-menu-menu-support-menu" class="block block-menu clearfix"> <h6 class="block-title">Support</h6> <ul class="menu nav"><li class="first leaf"><a href="/support/contact-us" id="menu-support-menu-603">Contact Us</a></li> <li class="leaf"><a href="/support/customer-support" id="menu-support-menu-14036">Customer Support</a></li> <li class="leaf"><a href="/distributors" id="menu-support-menu-601">Distributors</a></li> <li class="leaf"><a href="/about-tocris/licensing" id="menu-support-menu-14041">Licensing</a></li> <li class="leaf"><a href="/resources" id="menu-support-menu-14046">Scientific Resources</a></li> <li class="last leaf"><a href="/support/technical-support" id="menu-support-menu-14051">Technical Support</a></li> </ul> </section> </div> </nav> <nav class="footer_column footer_column_3 col-xs-12 col-sm-3"> <div class="region region-footer-column-3"> <section id="block-menu-menu-brands-menu" class="block block-menu clearfix"> <h6 class="block-title">Bio-Techne Brands</h6> <ul class="menu nav"><li class="first leaf"><a href="https://www.rndsystems.com/" title="" target="_blank" id="menu-brands-menu-605">R&D Systems</a></li> <li class="leaf"><a href="https://www.novusbio.com" title="" target="_blank" id="menu-brands-menu-606">Novus Biologicals</a></li> <li class="leaf"><a href="/" title="" id="menu-brands-menu-607">Tocris Bioscience</a></li> <li class="leaf"><a href="https://www.bio-techne.com/brands/proteinsimple" target="_blank" id="menu-brands-menu-608">ProteinSimple</a></li> <li class="last leaf"><a href="https://acdbio.com" title="" target="_blank" id="menu-brands-menu-9731">ACD</a></li> </ul> </section> </div> </nav> <div class="footer_column footer_column_4 col-xs-12 col-sm-3"> <div class="region region-footer-column-4"> <section id="block-block-2" class="block block-block clearfix"> <h6 class="block-title">Stay Connected</h6> <p>Get the latest news, product updates, and promotions:</p> <p><a class="btn btn-primary" href="/literature/signup" rel="nofollow">Sign Up for E-Alerts</a></p> <p>Follow Tocris:</p> <p><a class="social_link" href="https://www.linkedin.com/company/tocris-bioscience/" target="_blank" rel="nofollow"><span class="icon-linkedin-square">聽</span></a> <a class="social_link" href="https://www.facebook.com/TocrisBioscience/" target="_blank"><span class="icon-facebook-square">聽</span></a> <a class="social_link" href="https://twitter.com/Tocris" target="_blank"><span class="icon-twitter-square">聽</span></a></p> </section> </div> </div> </div> </div> </div> </footer> <div id="copyright_wrapper" class="container-fluid"> <div id="copyright_wrapper_container" class="row"> <div id="copyright" class="container"> <div id="copyright_container" class="row"> <div id="copyright_content" class="col-xs-12"> <p> <div class="region region-copyright"> <section id="block-block-4" class="block block-block clearfix"> © Copyright 2024 Tocris Bioscience. All Rights Reserved. <a href="/support/privacy-and-cookie-policy">Privacy and Cookie Policy</a> | <a href="/sitemap">Site Map</a> </section> </div> </p> </div> </div> </div> </div> </div> <script>var _hmt = _hmt || []; (function() { var hm = document.createElement("script"); hm.async = true; hm.defer = true; hm.src = "//hm.baidu.com/hm.js?7d34c554a46d6206cd64f92f2c696096"; var s = document.getElementsByTagName("script")[0]; s.parentNode.insertBefore(hm, s); })();</script> <script src="https://www.tocris.com/sites/tocris.com/files/js/js_MRdvkC2u4oGsp5wVxBG1pGV5NrCPW3mssHxIn6G9tGE.js"></script> <script type="text/javascript">window.NREUM||(NREUM={});NREUM.info={"beacon":"bam.nr-data.net","licenseKey":"76fb58fb05","applicationID":"788348528,30870807","transactionName":"YFdbZBFZXxdWAhAMVlkdeFMXUV4KGAQQOklfU0tdPFpDC0ASARdmX1dYVA==","queueTime":18,"applicationTime":443,"atts":"TBBYEllDTBk=","errorBeacon":"bam.nr-data.net","agent":""}</script></body> </html>