CINXE.COM

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class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Canada </div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.ca/fr">Français </a></div> <div class="field--item"><a href="https://www.alnylam.ca/">English</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--113 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Portugal</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-portugal">Português</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--1513 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Czech Republic</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-czech-republic">Čeština</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--115 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Spain </div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-espana">Español</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--116 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Denmark </div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-denmark">Dansk</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--117 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Sweden</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-sverige">Svenska</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--118 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">France</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.fr/">Français</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--119 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Switzerland</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-switzerland-french">Français</a></div> <div class="field--item"><a href="/alnylam-switzerland-german">Deutsch</a></div> <div class="field--item"><a href="/alnylam-switzerland-italian">Italiano</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--120 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Germany </div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.de/">Deutsch</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--121 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Taiwan</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-taiwan">繁體中文</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--1514 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Ireland </div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-ireland">English</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--123 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">United Kingdom</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-uk">English</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--122 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Italy</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.it/">Italiano</a></div> </div> </span> </div> </div> </div> </div> </section> </div> </div> </div> </div> </header> <div id="maindiv" class="container-fluid"> <main id="midcontent-area" class="column main-content"> <div id="content"> <div class="region region-content"> <div data-drupal-messages-fallback class="hidden"></div> <article data-history-node-id="749" role="article" about="/index.php/media-kit" typeof="schema:WebPage" class="page full clearfix"> <span property="schema:name" content="Media-kit" class="hidden"></span> <div class="content"> <div class="field field--name-field-add-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--sim paragraph-id--1515 paragraph--view-mode--default"> <div id="simple-banner-wrapper"> <div class="simple-banner" style=""> <div class="field field--name-field-upload-image field--type-image field--label-hidden field--item"> <img src="/sites/default/files/2022-01/media-hero-image.jpg" width="1280" height="184" alt="media-hero-image" loading="lazy" typeof="foaf:Image" class="img-responsive" /> </div> </div> <div class="quote" style="width:1130px; margin:auto;"> <div class="field field--name-field-qutote field--type-text-long field--label-hidden field--item"><style type="text/css"> <![CDATA[/* ><!]]>*/ </style></div> </div> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--banner-overlay-html-content paragraph-id--1516 paragraph--view-mode--default"> <div class="banner-overlay-html-content-description--component " style="width:1130px; margin:auto;"> <div class="field field--name-field-body field--type-text-with-summary field--label-hidden field--item"><p class="mobile-eyebrow"><span class="our-news">Our News</span></p> <h1 class="our-news text-align-center">MEDIA KIT</h1> <h2 class="text-align-center">Media Inquiries</h2> <p class="text-align-center"><strong>Christine Lindenboom</strong></p> <p class="text-align-center">Chief Corporate Communications Officer</p> <p class="text-align-center"><a href="mailto:media@alnylam.com">media@alnylam.com</a></p> </div> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--html-content-with-background paragraph-id--1518 paragraph--view-mode--default"> <div class="html-content-background " style="width:px; background-color: #00254b ;"> <div class="row inner-block" "> <div class="field field--name-field-html-content-bg field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--body paragraph-id--1517 paragraph--view-mode--default"> <div class="description--component" style="width:1100px; margin:auto; "> <div class="field field--name-field-body field--type-text-with-summary field--label-hidden field--item"><div class="row"> <div class="col-sm-6 left-text"> <h2>About Alnylam</h2> <p class="font-20">Founded in 2002, Alnylam was built upon a bold vision of turning scientific possibility into reality and is now advancing a new class of innovative medicines to address the needs of patients who have limited or inadequate treatment options. Our robust pipeline of investigational RNAi therapeutics is currently focused on several disease areas including transthyretin amyloidosis, rare diseases, cardiovascular diseases, metabolic diseases, and neurological diseases.</p> <p><a class="button-more" href="/about-alnylam/">Learn More About Alnylam ›</a></p> </div> <div class="col-sm-6 right-image"> <p><img alt="IMG" data-entity-type="file" data-entity-uuid="9c635d19-a669-4809-8761-4f2bf4f47a8c" src="/sites/default/files/inline-images/Alnylam_Corporate_Main_MediaKit.jpg" width="590" height="520" loading="lazy" /></p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--add-block paragraph-id--1519 paragraph--view-mode--default"> <div class="addblock--component" id="cr-in-action" style="width:1100px; margin:auto; "> <div class="field field--name-field-add-block field--type-block-field field--label-hidden field--item"><section class="views-element-container block block-views block-views-blockresources-block-1 clearfix" id="block-views-block-resources-block-1"> <h2 class="block-title">Resources</h2> <div class="form-group"><div class="view view-resources view-id-resources view-display-id-block_1 js-view-dom-id-dcb379a5699b2f6403e11a0162d58722559b4aa12b381c963463fe71b66e43ff"> <div class="view-content"> <div class="views-row"><div class="views-field views-field-nothing"><span class="field-content"><div class="content-box"> <div class="col-sm-9 left-content"> <h4>Corporate Backgrounder</h4> <div class="text"><p>A synopsis of our RNAi therapeutics, experience, and active pipeline.</p> </div> <div class="files"> <div class="file-uploaded"><ul><li><span class="file file--mime-application-pdf file--application-pdf icon-before"><span class="file-icon"><span class="icon glyphicon glyphicon-file text-primary" aria-hidden="true"></span></span><span class="file-link"><a href="https://www.alnylam.com/sites/default/files/2024-09/alnylam-corp-backgrounder.pdf" type="application/pdf; length=447520" title="Open file in new window" target="_blank" data-toggle="tooltip" data-placement="bottom">Download</a></span><span class="file-size">437.03 KB</span></span></li></ul></div> <div class="file-format">(Format: PDF)</div> </div> </div> <div class="col-sm-3 right-content"> <div class="ico-img"> <img src="/sites/default/files/2024-09/Resources_PDF_corporatebackgrounder_0.png" width="428" height="442" alt="" loading="lazy" typeof="Image" class="img-responsive" /> </div> </div> </div></span></div></div> <div class="views-row"><div class="views-field views-field-nothing"><span class="field-content"><div class="content-box"> <div class="col-sm-9 left-content"> <h4>RNAi Fact Sheet</h4> <div class="text"><p>Learn about the history of RNAi and what it means for the advancement of human therapeutics.</p> </div> <div class="files"> <div class="file-uploaded"><ul><li><span class="file file--mime-application-pdf file--application-pdf icon-before"><span class="file-icon"><span class="icon glyphicon glyphicon-file text-primary" aria-hidden="true"></span></span><span class="file-link"><a href="https://www.alnylam.com/sites/default/files/2023-05/RNAi-Factsheet_0.pdf" type="application/pdf; 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length=189591" title="Open file in new window" target="_blank" data-toggle="tooltip" data-placement="bottom">Download 2023 Report</a></span><span class="file-size">185.15 KB</span></span></li><li><span class="file file--mime-application-pdf file--application-pdf icon-before"><span class="file-icon"><span class="icon glyphicon glyphicon-file text-primary" aria-hidden="true"></span></span><span class="file-link"><a href="https://www.alnylam.com/sites/default/files/2023-09/alny-papr-factsheet-alnypapre.pdf" type="application/pdf; length=169477" title="Open file in new window" target="_blank" data-toggle="tooltip" data-placement="bottom">Download 2022 Report</a></span><span class="file-size">165.5 KB</span></span></li><li><span class="file file--mime-application-pdf file--application-pdf icon-before"><span class="file-icon"><span class="icon glyphicon glyphicon-file text-primary" aria-hidden="true"></span></span><span class="file-link"><a href="https://www.alnylam.com/sites/default/files/pdfs/Alnylam-Patient-Access-Philosophy-Report-2021.pdf" type="application/pdf; length=9589174" title="Open file in new window" target="_blank" data-toggle="tooltip" data-placement="bottom">Download 2021 Report</a></span><span class="file-size">9.14 MB</span></span></li></ul></div> <div class="file-format">(Format: PDF) (Format: PDF) (Format: PDF)</div> </div> </div> <div class="col-sm-3 right-content"> <div class="ico-img"> <img src="/sites/default/files/2024-04/patient-access-philosophy-media-kit.png" width="429" height="432" alt="" loading="lazy" typeof="Image" class="img-responsive" /> </div> </div> </div></span></div></div> <div class="views-row"><div class="views-field views-field-nothing"><span class="field-content"><div class="content-box"> <div class="col-sm-9 left-content"> <h4>Alnylam Assist®</h4> <div class="text"><p>An overview of our patient support program for U.S. residents.</p> </div> <div class="files"> <div class="file-uploaded"><ul><li><span class="file file--mime-application-pdf file--application-pdf icon-before"><span class="file-icon"><span class="icon glyphicon glyphicon-file text-primary" aria-hidden="true"></span></span><span class="file-link"><a href="https://www.alnylam.com/sites/default/files/pdfs/Alnylam-Assist-Fact-Sheet.pdf" type="application/pdf; 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length=31757" title="Open image in new window" target="_blank" data-toggle="tooltip" data-placement="bottom">Download</a></span><span class="file-size">31.01 KB</span></span></li></ul></div> <div class="file-format">(Format: PNG 31 KB)</div> </div> </div> <div class="col-sm-3 right-content"> <div class="ico-img"> <img src="/sites/default/files/2022-01/icon-corporate-logos.png" width="130" height="144" alt="" loading="lazy" typeof="Image" class="img-responsive" /> </div> </div> </div></span></div></div> <div class="views-row"><div class="views-field views-field-nothing"><span class="field-content"><div class="content-box"> <div class="col-sm-9 left-content"> <h4>Alnylam Rare Disease Trend Report</h4> <div class="text"><p>Our Rare Disease Trend Reports are based on survey responses from >30 U.S. payer and plan decision-makers and provides a unique window into the minds of insurers about orphan drug access.</p> </div> <div class="files"> <div class="file-uploaded"><ul><li><span class="file file--mime-application-pdf file--application-pdf icon-before"><span class="file-icon"><span class="icon glyphicon glyphicon-file text-primary" aria-hidden="true"></span></span><span class="file-link"><a href="https://www.alnylam.com/sites/default/files/2024-04/alnylam-rare-disease-trend-report-2023.pdf" type="application/pdf; length=16030127" title="Open file in new window" target="_blank" data-toggle="tooltip" data-placement="bottom">DOWNLOAD 2023 REPORT</a></span><span class="file-size">15.29 MB</span></span></li><li><span class="file file--mime-application-pdf file--application-pdf icon-before"><span class="file-icon"><span class="icon glyphicon glyphicon-file text-primary" aria-hidden="true"></span></span><span class="file-link"><a href="https://www.alnylam.com/sites/default/files/2023-04/alnylam-rare-disease-trend-report-2022.pdf" type="application/pdf; length=8985124" title="Open file in new window" target="_blank" data-toggle="tooltip" data-placement="bottom">DOWNLOAD 2022 REPORT</a></span><span class="file-size">8.57 MB</span></span></li><li><span class="file file--mime-application-pdf file--application-pdf icon-before"><span class="file-icon"><span class="icon glyphicon glyphicon-file text-primary" aria-hidden="true"></span></span><span class="file-link"><a href="https://www.alnylam.com/sites/default/files/pdfs/alnylam-rare-disease-trend-report-2021.pdf" type="application/pdf; length=11195202" title="Open file in new window" target="_blank" data-toggle="tooltip" data-placement="bottom">DOWNLOAD 2021 REPORT</a></span><span class="file-size">10.68 MB</span></span></li></ul></div> <div class="file-format">(Format: PDF) (Format: PDF) (Format: PDF)</div> </div> </div> <div class="col-sm-3 right-content"> <div class="ico-img"> <img src="/sites/default/files/2024-04/trend-report_0.png" width="816" height="519" alt="" loading="lazy" typeof="Image" class="img-responsive" /> </div> </div> </div></span></div></div> <div class="views-row"><div class="views-field views-field-nothing"><span class="field-content"><div class="content-box"> <div class="col-sm-9 left-content"> <h4>RNAi Activity Booklet for Kids</h4> <div class="text"><p>Learn about the basic science of RNAi through fun activities such word search, connect the dots, matching, and coloring. This activity booklet is intended for families and children aged 7-14.</p> </div> <div class="files"> <div class="file-uploaded"><ul><li><span class="file file--mime-application-pdf file--application-pdf icon-before"><span class="file-icon"><span class="icon glyphicon glyphicon-file text-primary" aria-hidden="true"></span></span><span class="file-link"><a href="https://www.alnylam.com/sites/default/files/2022-02/RNAi-Activity-Booklet.pdf" type="application/pdf; length=19788149" title="Open file in new window" target="_blank" data-toggle="tooltip" data-placement="bottom">Download</a></span><span class="file-size">18.87 MB</span></span></li></ul></div> <div class="file-format">(Format: PDF)</div> </div> </div> <div class="col-sm-3 right-content"> <div class="ico-img"> <img src="/sites/default/files/2022-02/rnai-booklet-thumbnail.png" width="143" height="144" alt="" loading="lazy" typeof="Image" class="img-responsive" /> </div> </div> </div></span></div></div> </div> </div> </div> </section> </div> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--html-content-with-background paragraph-id--1521 paragraph--view-mode--default"> <div class="html-content-background " style="width:px; background-color: #00254b ;"> <div class="row inner-block" "> <div class="field field--name-field-html-content-bg field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--body paragraph-id--1520 paragraph--view-mode--default"> <div class="description--component" style="width:970px; margin:auto; "> <div class="field field--name-field-body field--type-text-with-summary field--label-hidden field--item"><div class="header-part"> <div class="col-sm-9"> <h2>Management Board</h2> </div> <div class="col-sm-3"><a class="button-more" href="/about-alnylam/alnylam-leadership/">Read Bios ›</a></div> </div> <div class="body-part"> <div class="col-sm-6"> <h2 class="name">Yvonne Greenstreet, MBChB</h2> <h3 class="designation">Chief Executive Officer</h3> <div class="image-download-link"><a class="button-more-down-light" download="" href="/sites/default/files/2024-04/YGreenstreet-leadership-headshot.png" rel="noopener noreferrer" style="font-weight: normal;" target="_blank">DOWNLOAD PHOTO</a></div> </div> <div class="col-sm-6"> <h2 class="name">Robert Hesslein</h2> <h3 class="designation">Chief Legal Officer and Corporate Secretary</h3> <div class="image-download-link"><a class="button-more-down-light" download="" href="/sites/default/files/2024-10/RHesslein-leadership-headshot.png" rel="noopener noreferrer" style="font-weight: normal;" target="_blank">DOWNLOAD PHOTO</a></div> </div> <div class="col-sm-6"> <h2 class="name">Tolga Tanguler</h2> <h3 class="designation">Chief Commercial Officer</h3> <div class="image-download-link"><a class="button-more-down-light" download="" href="/sites/default/files/2024-04/TTanguler-leadership-headshot.png" rel="noopener noreferrer" style="font-weight: normal;" target="_blank">DOWNLOAD PHOTO</a></div> </div> <div class="col-sm-6"> <h2 class="name">Timothy Maines</h2> <h3 class="designation">Chief Technical Operations and Quality Officer</h3> <div class="image-download-link"><a class="button-more-down-light" download="" href="/sites/default/files/2024-04/TMaines-leadership-headshot.png" rel="noopener noreferrer" style="font-weight: normal;" target="_blank">DOWNLOAD PHOTO</a></div> </div> <div class="col-sm-6"> <h2 class="name">Jeff Poulton</h2> <h3 class="designation">Chief Financial Officer</h3> <div class="image-download-link"><a class="button-more-down-light" download="" href="/sites/default/files/2024-04/JPoulton-leadership-headshot.png" rel="noopener noreferrer" style="font-weight: normal;" target="_blank">DOWNLOAD PHOTO</a></div> </div> <div class="col-sm-6"> <h2 class="name">Pushkal Garg, MD</h2> <h3 class="designation">Chief Medical Officer and EVP, Development & Medical Affairs</h3> <div class="image-download-link"><a class="button-more-down-light" download="" href="/sites/default/files/2024-04/PGarg-leadership-headshot.png" rel="noopener noreferrer" style="font-weight: normal;" target="_blank">DOWNLOAD PHOTO</a></div> </div> <div class="col-sm-6"> <h2 class="name">Piyush Sharma, JD</h2> <h3 class="designation">Chief Ethics & Compliance Officer</h3> <div class="image-download-link"><a class="button-more-down-light" download="" href="/sites/default/files/2024-04/PSharma-leadership-headshot.png" rel="noopener noreferrer" style="font-weight: normal;" target="_blank">DOWNLOAD PHOTO</a></div> </div> <div class="col-sm-6"> <h2 class="name">Kelley Boucher</h2> <h3 class="designation">Chief Human Resource Officer</h3> <div class="image-download-link"><a class="button-more-down-light" download="" href="/sites/default/files/2024-11/KBoucher-leadership-headshot.jpg" rel="noopener noreferrer" style="font-weight: normal;" target="_blank">DOWNLOAD PHOTO</a></div> </div> <div class="col-sm-6"> <h2 class="name">Christine Lindenboom</h2> <h3 class="designation">Chief Corporate Communications Officer</h3> <div class="image-download-link"><a class="button-more-down-light" download="" href="/sites/default/files/2024-10/CLindenboom-leadership-headshot.png" rel="noopener noreferrer" style="font-weight: normal;" target="_blank">DOWNLOAD PHOTO</a></div> </div> <div class="col-sm-6"> <h2 class="name">Kevin Fitzgerald, PhD</h2> <h3 class="designation">Chief Scientific Officer</h3> <div class="image-download-link"><a class="button-more-down-light" download="" href="/sites/default/files/2024-04/KFitzgerald-leadership-headshot.png" rel="noopener noreferrer" style="font-weight: normal;" target="_blank">DOWNLOAD PHOTO</a></div> </div> <div class="col-sm-6"> <h2 class="name">Evan Lippman</h2> <h3 class="designation">Chief Corporate Development & Strategy Officer</h3> <div class="image-download-link"><a class="button-more-down-light" download="" href="/sites/default/files/2024-04/ELippman-leadership-headshot.png" rel="noopener noreferrer" style="font-weight: normal;" target="_blank">DOWNLOAD PHOTO</a></div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--html-content-with-background paragraph-id--1549 paragraph--view-mode--default"> <div class="html-content-background " style="width:px; background-color: ;"> <div class="row inner-block" "> <div class="field field--name-field-html-content-bg field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--body paragraph-id--1548 paragraph--view-mode--default"> <div class="description--component" style="width:970px; margin:auto; "> <div class="field field--name-field-body field--type-text-with-summary field--label-hidden field--item"><div class="our-science-of-rnai"> <h2>The Science of RNAi</h2> <p>RNA interference (RNAi) is a breakthrough in understanding how genes are regulated in cells. It also represents a completely new approach to drug discovery and development.</p> <a href="/our-science/the-science-of-rnai">Read More ›</a> <div class="row content-box"> <div class="col-sm-4 inner-box"> <h3>RNAi Therapeutics, A New Class of Medicine</h3> <a data-colorbox-inline=".yt-video1"><img alt="video1" src="/sites/default/files/2022-09/video-large-w-descriptor-our-science.jpg" /></a> <div class="play-button"><a data-colorbox-inline=".yt-video1"> </a></div> <a data-colorbox-inline=".yt-video1"> </a><iframe allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture" allowfullscreen="" class="yt-video1" frameborder="1" height="400" src="https://www.youtube.com/embed/ggVVhj88KQI" style="display: none" title="YouTube video player" width="650"></iframe></div> <div class="col-sm-4 inner-box"> <h3>RNAi Therapeutics, A New Class of Medicine</h3> <span contenteditable="false" tabindex="-1"><a data-colorbox-inline=".yt-video2" data-widget="image"><img alt="img" src="/sites/default/files/inline-images/video-img-2.png" /></a></span> <div class="play-button"><a data-colorbox-inline=".yt-video2" data-widget="image"> </a></div> <a data-colorbox-inline=".yt-video2" data-widget="image"> </a> <span contenteditable="false" tabindex="-1"><a data-colorbox-inline=".yt-video2" data-widget="image"> </a><span style="background:rgba(220,220,220,0.5);background-image:url(https://dev-alnylam-d9.pantheonsite.io/core/assets/vendor/ckeditor/plugins/widget/images/handle.png);display:none;"><img draggable="true" height="15" role="presentation" src="data:image/gif;base64,R0lGODlhAQABAPABAP///wAAACH5BAEKAAAALAAAAAABAAEAAAICRAEAOw==" title="Click and drag to move" width="15" /></span></span><iframe allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture" allowfullscreen="" class="yt-video2" frameborder="1" height="400" src="https://www.youtube.com/embed/ttr_8eOjWek" style="display: none" title="YouTube video player" width="650"></iframe></div> <div class="col-sm-4 inner-box"> <h3>RNAi Therapeutic Process</h3> <a data-colorbox-inline=".pop-img-media-kit"> <img alt="video2" src="/sites/default/files/2022-01/RNAi_Process_small.png" /> </a> <img alt="video2" class="pop-img-media-kit" src="/sites/default/files/inline-images/Alnylam_RNAi_Process.jpg" style="display: none" /> <p class="view-large"><a data-colorbox-inline=".pop-img-media-kit">View Larger</a></p> <span style=" background: rgba(220, 220, 220, 0.5); background-image: url(/core/assets/vendor/ckeditor/plugins/widget/images/handle.png); display: none; "><img draggable="true" height="15" role="presentation" src="data:image/gif;base64,R0lGODlhAQABAPABAP///wAAACH5BAEKAAAALAAAAAABAAEAAAICRAEAOw==" title="Click and drag to move" width="15" /></span></div> </div> <p class="download-img file-link"><a download="" href="/sites/default/files/inline-images/Alnylam_RNAi_Process.jpg" rel="noopener noreferrer" style="font-weight: normal" target="_blank">Download</a>(Format: Jpeg 173 KB)</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--add-block paragraph-id--1527 paragraph--view-mode--default"> <div class="addblock--component" id="cr-in-action" style="width:970px; margin:auto; "> <div class="field field--name-field-add-block field--type-block-field field--label-hidden field--item"><section class="views-element-container block block-views block-views-blockduplicate-of-resources-block-1 clearfix" id="block-views-block-duplicate-of-resources-block-1"> <div class="form-group"><div class="view view-duplicate-of-resources view-id-duplicate_of_resources view-display-id-block_1 js-view-dom-id-42242b01bf1889d3bd05e94bdf26dcb2306f963d9db6fdb98bfeec5a8aaeec21"> </div> </div> </section> </div> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--add-block paragraph-id--1528 paragraph--view-mode--default"> <div class="addblock--component" id="cr-in-action" style="width:970px; margin:auto; "> <div class="field field--name-field-add-block field--type-block-field field--label-hidden field--item"><section class="views-element-container block block-views block-views-blockdisease-information-block-1 clearfix" id="block-views-block-disease-information-block-1"> <h2 class="block-title">Disease Information</h2> <div class="form-group"><div class="view view-disease-information view-id-disease_information view-display-id-block_1 js-view-dom-id-0ab78d53a919a728d5766e3a2eae3da0640f2690c1ef62d0dcabcab1d8637f12"> <div class="view-content"> <div class="views-row"><div class="views-field views-field-nothing"><span class="field-content"><div class="disease-info"> <h3>About Acute Hepatic Porphyria</h3> <div class="files"> <span class="file file--mime-application-pdf file--application-pdf icon-before"><span class="file-icon"><span class="icon glyphicon glyphicon-file text-primary" aria-hidden="true"></span></span><span class="file-link"><a href="https://www.alnylam.com/sites/default/files/pdfs/acute-hepatic-porphyria-backgrounder-us.pdf" type="application/pdf; length=272039" title="Open file in new window" target="_blank" data-toggle="tooltip" data-placement="bottom">Download Fact Sheet</a></span><span class="file-size">265.66 KB</span></span> (Format: PDF) </div> <div class="text"> <p>Acute hepatic porphyria (AHP) refers to a family of rare, genetic diseases characterized by potentially life-threatening attacks and, for some patients, chronic debilitating symptoms that negatively impact daily functioning and quality of life. AHP comprises 4 subtypes, each resulting from a genetic defect leading to deficiency in one of the enzymes of the heme biosynthesis pathway in the liver: acute intermittent porphyria, hereditary coproporphyria, variegate porphyria, and ALAD-deficiency porphyria.</p> </div> </div></span></div></div> <div class="views-row"><div class="views-field views-field-nothing"><span class="field-content"><div class="disease-info"> <h3>About ATTR Amyloidosis</h3> <div class="files"> <span class="file file--mime-application-pdf file--application-pdf icon-before"><span class="file-icon"><span class="icon glyphicon glyphicon-file text-primary" aria-hidden="true"></span></span><span class="file-link"><a href="https://www.alnylam.com/sites/default/files/2023-10/attr-amyloidosis-backgrounder.pdf" type="application/pdf; length=161609" title="Open file in new window" target="_blank" data-toggle="tooltip" data-placement="bottom">Download Fact Sheet</a></span><span class="file-size">157.82 KB</span></span> (Format: PDF) </div> <div class="text"> <p>Transthyretin-mediated (ATTR) amyloidosis is an underdiagnosed, rapidly progressive, debilitating and fatal disease caused by misfolded transthyretin (TTR) proteins. The misfolded TTR proteins collect as amyloid deposits throughout the body, including the nerves, heart and digestive system, resulting in progressive organ damage. There are two different types of ATTR amyloidosis – hereditary ATTR (hATTR) amyloidosis, which is caused by an inherited variant, or change, in the TTR gene, and wild-type ATTR (wtATTR) amyloidosis, which occurs without a TTR gene variant.</p> </div> </div></span></div></div> <div class="views-row"><div class="views-field views-field-nothing"><span class="field-content"><div class="disease-info"> <h3>About Primary Hyperoxaluria Type 1</h3> <div class="files"> <span class="file file--mime-application-pdf file--application-pdf icon-before"><span class="file-icon"><span class="icon glyphicon glyphicon-file text-primary" aria-hidden="true"></span></span><span class="file-link"><a href="https://www.alnylam.com/sites/default/files/2023-05/ph1-disease-burden-infographic-us-0.pdf" type="application/pdf; length=340264" title="Open file in new window" target="_blank" data-toggle="tooltip" data-placement="bottom">Download Fact Sheet</a></span><span class="file-size">332.29 KB</span></span> (Format: PDF) </div> <div class="text"> <p>Primary hyperoxaluria (PH) constitutes a group of rare inherited disorders of the liver characterized by the overproduction of oxalate, an end-product of metabolism. There are 3 types of PH: type 1 (PH1), type 2 (PH2), and type 3 (PH3). PH1 is the most common and severe form, accounting for 70% to 80% of all cases. PH1 affects approximately 4 individuals per million in the United States and Europe, with an estimated 1,300 to 2,100 diagnosed cases. In some regions, such as the Middle East and North Africa, the genetic prevalence of PH1 is higher.</p> </div> </div></span></div></div> <div class="views-row"><div class="views-field views-field-nothing"><span class="field-content"><div class="disease-info"> <h3>About Hypertension</h3> <div class="files"> <span class="file file--mime-application-pdf file--application-pdf icon-before"><span class="file-icon"><span class="icon glyphicon glyphicon-file text-primary" aria-hidden="true"></span></span><span class="file-link"><a href="https://www.alnylam.com/sites/default/files/2024-03/hypertension-fact-sheet-us.pdf" type="application/pdf; length=175367" title="Open file in new window" target="_blank" data-toggle="tooltip" data-placement="bottom">Download Fact Sheet</a></span><span class="file-size">171.26 KB</span></span> (Format: PDF) </div> <div class="text"> <p>Hypertension, also known as high blood pressure, is a complex multifactorial disease clinically defined by most major guidelines as a systolic blood pressure (SBP) of above 140 mm Hg or a diastolic blood pressure (DBP) greater than 90 mm Hg, though some guidelines have a lower threshold of a SBP above 130 mm Hg or a DBP greater than 80 mm Hg. More than one billion people worldwide live with hypertension, and fewer than 20 percent of those affected have it under control.</p> </div> </div></span></div></div> </div> </div> </div> </section> </div> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--html-content-with-background paragraph-id--1536 paragraph--view-mode--default"> <div class="html-content-background " style="width:px; background-color: ;"> <div class="row inner-block" "> <div class="field field--name-field-html-content-bg field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--body paragraph-id--1535 paragraph--view-mode--default"> <div class="description--component" style="width:970px; margin:auto; "> <div class="field field--name-field-body field--type-text-with-summary field--label-hidden field--item"><div class="products-and-pipeline"> <h2>Products and Pipeline</h2> <p>Our robust pipeline of investigational RNAi therapeutics is currently focused on several disease areas including transthyretin amyloidosis, rare diseases, cardiovascular diseases, metabolic diseases, and neurological diseases. We have multiple programs in late-stage and early-stage clinical development.</p> <div class="row content-box"> <div class="col-sm-6 inner-box"> <h3>ONPATTRO® (patisiran)</h3> <p>Now available in the United States.</p> <p class="file-link"><a download="" href="/wp-content/uploads/pdfs/ONPATTRO-Fact-Sheet.pdf" rel="noopener" style="font-weight: 400" target="_blank">Download Fact Sheet</a>(Format: PDF)</p> <a class="button-more" data-colorbox-inline=".pop-content1">Visit Website ›</a> <div class="pop-content1 pop-content" style="display: none"> <h1 class="text-center">YOU ARE NOW LEAVING ALNYLAM.COM</h1> <p class="text-center">You are now being directed to another Alnylam website that contains information about specific treatment(s).</p> <p class="text-center"><a class="our-products-ext dark-button-more" href="https://www.onpattro.com/">Proceed to Site ›</a></p> </div> </div> <div class="col-sm-6 inner-box"> <h3>GIVLAARI® (givosiran)</h3> <p>Now available in the United States.</p> <p class="file-link"><a download="" href="/wp-content/uploads/pdfs/GIVLAARI-Product-Fact-Sheet.pdf" rel="noopener" style="font-weight: 400" target="_blank">Download Fact Sheet</a>(Format: PDF)</p> <a class="button-more" data-colorbox-inline=".pop-content2">Visit Website ›</a> <div class="pop-content2 pop-content" style="display: none"> <h1 class="text-center">YOU ARE NOW LEAVING ALNYLAM.COM</h1> <p class="text-center">You are now being directed to another Alnylam website that contains information about specific treatment(s).</p> <p class="text-center"><a class="our-products-ext dark-button-more" href="https://www.givlaari.com/">Proceed to Site ›</a></p> </div> </div> <div class="col-sm-6 inner-box"> <h3>OXLUMO® (lumasiran)</h3> <p>Now available in the United States.</p> <p class="file-link"><a download="" href="/sites/default/files/pdfs/oxlumo-product-fact-sheet-for-media-us-updated-2023.pdf
" rel="noopener" style="font-weight: 400" target="_blank">Download Fact Sheet</a>(Format: PDF)</p> <a class="button-more" data-colorbox-inline=".pop-content3">Visit Website ›</a> <div class="pop-content3 pop-content" style="display: none"> <h1 class="text-center">YOU ARE NOW LEAVING ALNYLAM.COM</h1> <p class="text-center">You are now being directed to another Alnylam website that contains information about specific treatment(s).</p> <p class="text-center"><a class="our-products-ext dark-button-more" href="https://www.oxlumo.com/">Proceed to Site ›</a></p> </div> </div> <div class="col-sm-6 inner-box"> <h3>AMVUTTRA® (vutrisiran)</h3> <p>Now available in the United States.</p> <p class="file-link"><a download="" href="/sites/default/files/pdfs/AMVUTTRA-fact-sheet.pdf" rel="noopener" style="font-weight: 400" target="_blank">Download Fact Sheet</a>(Format: PDF)</p> <a class="button-more" data-colorbox-inline=".amv">Visit Website ›</a> <div class="pop-content3 amv pop-content" style="display: none"> <h1 class="text-center">YOU ARE NOW LEAVING ALNYLAM.COM</h1> <p class="text-center">You are now being directed to another Alnylam website that contains information about specific treatment(s).</p> <p class="text-center"><a class="our-products-ext dark-button-more" href="https://www.amvuttra.com/">Proceed to Site ›</a></p> </div> </div> <div class="col-sm-6 inner-box"> <h3>Zilebesiran</h3> <p>Investigational therapeutic for the treatment of hypertension.</p> <p class="file-link"><a download="" href="/wp-content/uploads/pdfs/ALN-AGT-Fact-Sheet.pdf" rel="noopener" style="font-weight: 400" target="_blank">Download Fact Sheet</a>(Format: PDF)</p> <p> </p> </div> <div class="col-sm-6 inner-box"> <h3>Mivelsiran (ALN-APP)</h3> <p>Investigational therapeutic for the treatment of Alzheimer’s Disease</p> <p class="file-link"><a download="" href="/sites/default/files/pdfs/mivelsiran-aln-app-fact-sheet.pdf" rel="noopener" style="font-weight: 400" target="_blank">Download Fact Sheet</a>(Format: PDF)</p> <p> </p> </div> </div> <a class="cta-to-pipeline-page" href="/alnylam-rnai-pipeline/">See the Rest of Our Pipeline ›</a></div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--html-content-with-background paragraph-id--1534 paragraph--view-mode--default"> <div class="html-content-background " style="width:px; background-color: ;"> <div class="row inner-block" "> <div class="field field--name-field-html-content-bg field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--body paragraph-id--1533 paragraph--view-mode--default"> <div class="description--component" style="width:970px; margin:auto; "> <div class="field field--name-field-body field--type-text-with-summary field--label-hidden field--item"><div class="clinical-trials"> <h2>Clinical Trials</h2> <p>Our clinical studies allow us to evaluate whether potential new treatments are safe and effective.</p> <div class="row content-box"> <div class="whole-img-content-section"> <div class="col-sm-2 img-section"><img alt="img" data-entity-type="file" data-entity-uuid="1be71622-d94e-4330-88fe-a029d9bfeb4d" src="/sites/default/files/inline-images/Apollo-Logo_168px.png" width="168" height="48" loading="lazy" /></div> <div class="col-sm-10 content-section"> <h3>APOLLO and APOLLO-B Phase 3 Studies</h3> <p>APOLLO evaluated the efficacy and safety of patisiran in patients with the polyneuropathy of hereditary transthyretin-mediated (hATTR) amyloidosis, and APOLLO-B is evaluating patisiran in patients with the cardiomyopathy of wild-type transthyretin-mediated (wtATTR) amyloidosis or hATTR amyloidosis.</p> <p class="file-link"><a href="/sites/default/files/pdfs/apollo-and-apollo-b-fact-sheet.pdf" target="_blank">Download Fact Sheet</a>(Format: PDF)</p> </div> </div> <div class="whole-img-content-section"> <div class="col-sm-2 img-section"><img alt="img" data-entity-type="file" data-entity-uuid="c8df8bd3-3cd1-4b80-83b0-4c8f3b0abca8" src="/sites/default/files/inline-images/ENVISION%20Logo_Purple_0.png" width="259" height="89" loading="lazy" /></div> <div class="col-sm-10 content-section"> <h3>ENVISION Phase 3 Study</h3> <p>The ENVISION Phase 3 study evaluated the efficacy and safety of givosiran in patients with acute hepatic porphyria (AHP).</p> <p class="file-link"><a href="/sites/default/files/pdfs/ENVISION-Fact-Sheet.pdf" target="_blank">Download Fact Sheet</a>(Format: PDF)</p> </div> </div> <div class="whole-img-content-section"> <div class="col-sm-2 img-section"><img alt="img" data-entity-type="file" data-entity-uuid="3e4dda56-0a84-4892-9fad-61f4ffbfcdf7" src="/sites/default/files/inline-images/logo-illuminate-resized.png" width="96" height="119" loading="lazy" /></div> <div class="col-sm-10 content-section"> <h3>ILLUMINATE-A, -B, and -C Phase 3 Studies</h3> <p>ILLUMINATE-A randomized, double-blind, placebo-controlled Phase 3 study evaluating safety and efficacy of lumasiran in children (age 6 or older) and adults with PH1. ILLUMINATE-B open-label, multicenter Phase 3 study evaluating safety and efficacy of lumasiran in infants and young children (under the age of 6) with PH1. ILLUMINATE-C open-label, multicenter Phase 3 study evaluating safety and efficacy of lumasiran in PH1 patients of all ages with advanced renal disease, including patients on dialysis.</p> <p class="file-link"><a href="/sites/default/files/pdfs/Lumasiran-ILLUMINATE-Fact-Sheet.pdf" target="_blank">Download Fact Sheet</a>(Format: PDF)</p> </div> </div> <div class="whole-img-content-section"> <div class="col-sm-2 img-section"><img alt="img" data-entity-type="file" data-entity-uuid="ca42c894-42a5-4c82-8a41-1bbbdd9fd114" src="/sites/default/files/inline-images/Helios-A-Logo.jpg" width="100" height="107" loading="lazy" /></div> <div class="col-sm-10 content-section"> <h3>HELIOS-A and -B Phase 3 Studies</h3> <p>Evaluating the efficacy and safety of vutrisiran in patients with hereditary transthyretin amyloidosis (hATTR amyloidosis) and with transthyretin amyloidosis cardiomyopathy (ATTR amyloidosis with cardiomyopathy).</p> <p class="file-link"><a href="/sites/default/files/pdfs/helios-fact-sheet.pdf" target="_blank">Download Fact Sheet</a>(Format: PDF)</p> </div> </div> <div class="whole-img-content-section"> <div class="col-sm-2 img-section"><img alt="img" data-entity-type="file" data-entity-uuid="85c17634-26c9-4928-88bc-566d6554ef60" src="/sites/default/files/inline-images/Kardia_General_logo_0.png" width="1101" height="202" loading="lazy" /></div> <div class="col-sm-10 content-section"> <h3>KARDIA Phase 2 Studies</h3> <p>Evaluating the efficacy and safety of zilebesiran as monotherapy across different doses administered quarterly and biannually in patients with mild-to-moderate hypertension, and when used in combination with conventional antihypertensive medications.</p> <p class="file-link"><a href="/sites/default/files/pdfs/KARDIA-1-Fact-Sheet.pdf" target="_blank">Download Fact Sheet</a>(Format: PDF)</p> <p class="file-link"> </p> </div> </div> </div> <p class="margin-top-24px"><a href="/alnylam-rnai-pipeline/clinical-trials/">Click here</a> to see all of our clinical studies.</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="field field--name-field-custom-body-class field--type-string field--label-above"> <div class="field--label">Custom Body Class</div> <div class="field--item">media-kit</div> </div> </div> </article> <section id="block-interstitialmodal" class="block block-block-content block-block-content91077066-95c8-4915-8931-1413e257836b clearfix"> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item"> <div class="modal" id="inter-modal" role="dialog" tabindex="-1"> <div class="inner" role="document"> <button aria-label="Close" class="close" data-dismiss="modal" type="button"></button> <div class="content"> <div class="title">You are now leaving Alnylam.com</div> <p>The following content may not be associated with Alnylam Pharmaceuticals.</p> <p>Links to all outside 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