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1.5h-3" style="stroke-linecap:round;stroke-linejoin:round;fill:currentColor;stroke-width:.5px"></path><path d="M3.75 9.749h1.5" style="stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px;stroke-opacity:1"></path><path d="M5.25 12.749h13.5v10H5.25z" class="paper" style="stroke-linecap:round;stroke-linejoin:round;fill:currentColor;stroke-width:2"></path><path d="M18.75 6.749H5.25v-4.5a1.5 1.5 0 0 1 1.5-1.5h10.5a1.5 1.5 0 0 1 1.5 1.5Z" style="stroke-linecap:round;stroke-linejoin:round;fill:currentColor;stroke-width:.25px;stroke-opacity:1"></path></svg></button></li></ul></div><div><div class="generic-paragraph"><div class="generic-paragraph__text"><p>Data collection for the ABC-CT will take place across five sites:</p> <ul> <li>Duke University</li> <li>Boston Children’s Hospital</li> <li>Children's Hospital Los Angeles </li> <li>University of Washington</li> <li>Yale University</li> </ul> <p>All of these sites are overseen by faculty members who are highly experienced in multi-site collaborative clinical research in children with ASD using the methods to be utilized for this project. <br></p></div></div></div> </section></div><div class="component-wrapper component-wrapper--all"><div class="table-of-contents"><nav class="table-of-contents__navigation" aria-label="On this page"><h2 class="table-of-contents__title">On this page</h2><ul class="table-of-contents__links table-of-contents__links--with-sidebar table-of-contents__links--has-columns"></ul></nav><div class="component-wrapper component-wrapper--all"><section class="generic-content" aria-label="Duke University - Geraldine Dawson, Ph.D."><div class="generic-content__title-container"><div class="heading__container"><h2 id="duke-university-geraldine-dawson,-phd" class="generic-content__title">Duke University - Geraldine Dawson, Ph.D.</h2><div class="generic-content__subtitle">Collaborating Implementation Site Director</div><div class="heading__anchor-copy-button-container"><button type="button" 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1-.134.558 3.73 3.73 0 0 0 .383 4.859 3.73 3.73 0 0 0 2.65 1.096 3.73 3.73 0 0 0 2.654-1.1l4.773-4.773c.708-.708 1.098-1.65 1.098-2.652s-.39-1.943-1.098-2.652c-.707-.707-1.649-1.096-2.652-1.096s-1.945.389-2.652 1.096l-.75.75a.744.744 0 0 1-1.06 0c-.142-.141-.22-.33-.22-.53s.078-.389.22-.53l.75-.75c.99-.99 2.309-1.536 3.712-1.536s2.722.545 3.712 1.536a5.21 5.21 0 0 1 1.538 3.712 5.21 5.21 0 0 1-1.538 3.712l-4.773 4.773a5.21 5.21 0 0 1-3.711 1.54z"></path></svg></span></button></div></div></div><div><div class="generic-paragraph"><div class="generic-paragraph__photo-container"><figure class="photo photo--medium floating-photo floating-photo--right"><div class="photo__image-container"><span class="" style="display:inline-block"></span></div><figcaption class="photo__details"><div class="photo__caption-container"><div class="photo__caption">Geraldine Dawson, Ph.D. <br /></div></div></figcaption></figure></div><div class="generic-paragraph__text">Geraldine Dawson, Ph.D., Duke Collaborating Implementation Site (CIS) Director. Dr. Dawson is Professor of Psychiatry and Behavioral Sciences, Psychology, and Neuroscience and Director of the Duke Center for Autism and Brain Development at Duke University School of Medicine. Her research focuses on recognizing and understanding the neural bases of the earliest manifestations of autism and early interventions that can improve outcomes. Her laboratory pioneered the use of electrophysiological measures with very young children with autism to study the brain basis of impairments in social and language development. She is an expert in the use of EEG measures to assess brain function in individuals with ASD and has been the PI on a NIH-funded randomized clinical trial that utilized EEG as an endpoint. She co-led the team that developed and empirically-validated the first behavioral intervention for infants and toddlers with autism (Early Start Denver Model). Dr. Dawson is currently Co-PI on a program of clinical trials research evaluating the efficacy of umbilical cord blood therapy for reducing core symptoms of ASD using eye-tracking and EEG as surrogate endpoints. She regularly collaborates with other autism researchers from a wide range of disciplines, ranging from genetics to animal models to community dissemination research. <br><br><a href="https://autismcenter.duke.edu/content/geraldine-dawson-phd">Learn more about Dr. Dawson.</a><br></div></div></div> </section></div><div class="component-wrapper component-wrapper--all"><section class="generic-content" aria-label="Boston Children’s Hospital - Susan Faja, PhD"><div class="generic-content__title-container"><div class="heading__container"><h2 id="boston-childrens-hospital-susan-faja,-phd" class="generic-content__title">Boston Children’s Hospital - Susan Faja, PhD</h2><div class="generic-content__subtitle">Collaborating Implementation Site Director, Director Clinical Workgroup</div><div class="heading__anchor-copy-button-container"><button type="button" aria-label="Copy Link" class="anchor-copy-button anchor-copy-button--color-mode--dark"><span class="anchor-copy-button__content"><span class="anchor-copy-button__text">Copy Link</span><svg xmlns="http://www.w3.org/2000/svg" xml:space="preserve" viewBox="0 0 24 24" focusable="false" class="anchor-copy-button__icon"><path d="M5.253 21.497a5.21 5.21 0 0 1-3.712-1.535A5.21 5.21 0 0 1 .006 16.25c0-1.404.545-2.722 1.535-3.712l4.773-4.774a5.22 5.22 0 0 1 3.716-1.539c1.402 0 2.719.544 3.708 1.531a5.225 5.225 0 0 1 .538 6.804.75.75 0 0 1-1.048.165.74.74 0 0 1-.299-.489.75.75 0 0 1 .134-.558 3.73 3.73 0 0 0-.384-4.86 3.73 3.73 0 0 0-2.649-1.094 3.73 3.73 0 0 0-2.655 1.099l-4.774 4.774a3.754 3.754 0 0 0 0 5.303c.707.707 1.649 1.096 2.652 1.096s1.945-.389 2.652-1.096l.932-.932a.744.744 0 0 1 1.06 0 .744.744 0 0 1 0 1.06l-.932.932a5.2 5.2 0 0 1-3.712 1.537"></path><path d="M13.978 18.024a5.21 5.21 0 0 1-3.709-1.535 5.22 5.22 0 0 1-.536-6.803.75.75 0 0 1 1.047-.166.75.75 0 0 1 .3.49.75.75 0 0 1-.134.558 3.73 3.73 0 0 0 .383 4.859 3.73 3.73 0 0 0 2.65 1.096 3.73 3.73 0 0 0 2.654-1.1l4.773-4.773c.708-.708 1.098-1.65 1.098-2.652s-.39-1.943-1.098-2.652c-.707-.707-1.649-1.096-2.652-1.096s-1.945.389-2.652 1.096l-.75.75a.744.744 0 0 1-1.06 0c-.142-.141-.22-.33-.22-.53s.078-.389.22-.53l.75-.75c.99-.99 2.309-1.536 3.712-1.536s2.722.545 3.712 1.536a5.21 5.21 0 0 1 1.538 3.712 5.21 5.21 0 0 1-1.538 3.712l-4.773 4.773a5.21 5.21 0 0 1-3.711 1.54z"></path></svg></span></button></div></div></div><div><div class="generic-paragraph"><div class="generic-paragraph__text"><p>Dr. Faja studied Neuroscience at the University of Michigan before receiving her doctoral degree in Child Clinical Psychology from the University of Washington in 2009. She completed an internship at UCLA in the developmental disabilities track and postdoctoral fellowships focused on clinical neuroscience at the Children’s Hospital of Philadelphia and the University of Washington. Her research within the Laboratories of Cognitive Neuroscience investigates brain development and treatment response in clinical populations. In particular, she employs brain and behavioral measurement of social perception and executive control in children with autism spectrum disorder (ASD) and other neurodevelopmental disorders. A key focus of her work is translating existing training programs in the cognitive neuroscience literature for clinical use. An additional benefit of evaluating these interventions is the opportunity to directly test the plasticity of systems that have been implicated in the neurocognitive profile of ASD. She is also currently testing whether individual differences measured during cognitive tasks are meaningfully related to the social function and symptoms of young children with ASD and health outcomes of adults on the spectrum. By answering these questions, Dr. Faja will gain information about the risk factors and developmental sequences that are critical for development of ASD, other neurodevelopmental disorders, and typical development. In order to answer these questions, Dr. Faja’s lab seeks to improve the sensitivity of measurement used to capture the skills of individuals across a wide range of functioning.</p> <p> <a href="https://www.childrenshospital.org/directory/susan-faja">Learn more about Susan Faja, PhD</a> </p></div></div></div> </section></div><div class="component-wrapper component-wrapper--all"><section class="generic-content" aria-label="CHLA - Shafali Jeste, MD"><div class="generic-content__title-container"><div class="heading__container"><h2 id="chla-shafali-jeste,-md" class="generic-content__title">CHLA - Shafali Jeste, MD</h2><div class="generic-content__subtitle">Collaborating Implementation Site Director</div><div class="heading__anchor-copy-button-container"><button type="button" aria-label="Copy Link" class="anchor-copy-button anchor-copy-button--color-mode--dark"><span class="anchor-copy-button__content"><span class="anchor-copy-button__text">Copy Link</span><svg xmlns="http://www.w3.org/2000/svg" xml:space="preserve" viewBox="0 0 24 24" focusable="false" class="anchor-copy-button__icon"><path d="M5.253 21.497a5.21 5.21 0 0 1-3.712-1.535A5.21 5.21 0 0 1 .006 16.25c0-1.404.545-2.722 1.535-3.712l4.773-4.774a5.22 5.22 0 0 1 3.716-1.539c1.402 0 2.719.544 3.708 1.531a5.225 5.225 0 0 1 .538 6.804.75.75 0 0 1-1.048.165.74.74 0 0 1-.299-.489.75.75 0 0 1 .134-.558 3.73 3.73 0 0 0-.384-4.86 3.73 3.73 0 0 0-2.649-1.094 3.73 3.73 0 0 0-2.655 1.099l-4.774 4.774a3.754 3.754 0 0 0 0 5.303c.707.707 1.649 1.096 2.652 1.096s1.945-.389 2.652-1.096l.932-.932a.744.744 0 0 1 1.06 0 .744.744 0 0 1 0 1.06l-.932.932a5.2 5.2 0 0 1-3.712 1.537"></path><path d="M13.978 18.024a5.21 5.21 0 0 1-3.709-1.535 5.22 5.22 0 0 1-.536-6.803.75.75 0 0 1 1.047-.166.75.75 0 0 1 .3.49.75.75 0 0 1-.134.558 3.73 3.73 0 0 0 .383 4.859 3.73 3.73 0 0 0 2.65 1.096 3.73 3.73 0 0 0 2.654-1.1l4.773-4.773c.708-.708 1.098-1.65 1.098-2.652s-.39-1.943-1.098-2.652c-.707-.707-1.649-1.096-2.652-1.096s-1.945.389-2.652 1.096l-.75.75a.744.744 0 0 1-1.06 0c-.142-.141-.22-.33-.22-.53s.078-.389.22-.53l.75-.75c.99-.99 2.309-1.536 3.712-1.536s2.722.545 3.712 1.536a5.21 5.21 0 0 1 1.538 3.712 5.21 5.21 0 0 1-1.538 3.712l-4.773 4.773a5.21 5.21 0 0 1-3.711 1.54z"></path></svg></span></button></div></div></div><div><div class="generic-paragraph"><div class="generic-paragraph__photo-container"><figure class="photo photo--small floating-photo floating-photo--right"><div class="photo__image-container"><span class="" style="display:inline-block"></span></div><figcaption class="photo__details"><div class="photo__caption-container"><div class="photo__caption">Shafali Jeste, MD <br /></div></div></figcaption></figure></div><div class="generic-paragraph__text"><p>Dr. Jeste is a behavioral child neurologist specializing in autism and related neurodevelopmental disorders. She is Professor of Pediatrics and Neurology at the USC Keck School of Medicine, and the Las Madrinas Chair, Chief of Neurology and Co-Director of the Neurological Institute at CHLA. After earning a BA in philosophy from Yale University in 1997 and her MD from Harvard Medical School in 2002, Dr. Jeste completed a residency in child neurology and a fellowship in behavioral child neurology at Boston Children’s Hospital. She joined UCLA in 2010. Dr. Jeste’s research is focused on developing methods to improve precision in the diagnosis and treatment of neurodevelopmental disorders. Her lab studies neurodevelopmental disorders from early infancy through late childhood. Dr. Jeste has designed innovative studies in early predictors of autism in Tuberous Sclerosis Complex (TSC) that integrate biomarkers with behavior to define atypical development prior to the onset of autism. This work in TSC has led to the first randomized controlled clinical trial of behavioral intervention for these infants and has paved the way for other early intervention trials in rare genetic syndromes. Dr. Jeste’s research is directly inspired by her clinical work. To address the many gaps in medical care for rare genetic forms of neurodevelopmental disorders, she developed the Neurogenetics and Developmental Disabilities Clinic at CHLA. Dr. Jeste’s work is funded by the National Institutes of Health, the Department of Defense and the Simons Foundation. She holds several national and international leadership positions including the Board of Directors of the American Brain Foundation, Board of Directors of the National Organization for Rare Disorders, the Board of Directors of the International Society for Autism Research, and she recently served as the Chair of the International Baby Siblings Research Consortium. In 2019 she was awarded the Presidential Early Career Award for Scientists and Engineers for her innovations in research in early predictors and intervention for genetic neurodevelopmental disorders. <br><br><a href="https://www.chla.org/kinddlab">Click here to learn more about Dr. Jeste's Work</a>. <br></p></div></div></div> </section></div><div class="component-wrapper component-wrapper--all"><section class="generic-content" aria-label="University of Washington - Natalia Kleinhans, PhD "><div class="generic-content__title-container"><div class="heading__container"><h2 id="university-of-washington-natalia-kleinhans,-phd" class="generic-content__title">University of Washington - Natalia Kleinhans, PhD </h2><div class="generic-content__subtitle">Collaborating Implementation Site Director</div><div class="heading__anchor-copy-button-container"><button type="button" aria-label="Copy Link" class="anchor-copy-button anchor-copy-button--color-mode--dark"><span class="anchor-copy-button__content"><span class="anchor-copy-button__text">Copy Link</span><svg xmlns="http://www.w3.org/2000/svg" xml:space="preserve" viewBox="0 0 24 24" focusable="false" class="anchor-copy-button__icon"><path d="M5.253 21.497a5.21 5.21 0 0 1-3.712-1.535A5.21 5.21 0 0 1 .006 16.25c0-1.404.545-2.722 1.535-3.712l4.773-4.774a5.22 5.22 0 0 1 3.716-1.539c1.402 0 2.719.544 3.708 1.531a5.225 5.225 0 0 1 .538 6.804.75.75 0 0 1-1.048.165.74.74 0 0 1-.299-.489.75.75 0 0 1 .134-.558 3.73 3.73 0 0 0-.384-4.86 3.73 3.73 0 0 0-2.649-1.094 3.73 3.73 0 0 0-2.655 1.099l-4.774 4.774a3.754 3.754 0 0 0 0 5.303c.707.707 1.649 1.096 2.652 1.096s1.945-.389 2.652-1.096l.932-.932a.744.744 0 0 1 1.06 0 .744.744 0 0 1 0 1.06l-.932.932a5.2 5.2 0 0 1-3.712 1.537"></path><path d="M13.978 18.024a5.21 5.21 0 0 1-3.709-1.535 5.22 5.22 0 0 1-.536-6.803.75.75 0 0 1 1.047-.166.75.75 0 0 1 .3.49.75.75 0 0 1-.134.558 3.73 3.73 0 0 0 .383 4.859 3.73 3.73 0 0 0 2.65 1.096 3.73 3.73 0 0 0 2.654-1.1l4.773-4.773c.708-.708 1.098-1.65 1.098-2.652s-.39-1.943-1.098-2.652c-.707-.707-1.649-1.096-2.652-1.096s-1.945.389-2.652 1.096l-.75.75a.744.744 0 0 1-1.06 0c-.142-.141-.22-.33-.22-.53s.078-.389.22-.53l.75-.75c.99-.99 2.309-1.536 3.712-1.536s2.722.545 3.712 1.536a5.21 5.21 0 0 1 1.538 3.712 5.21 5.21 0 0 1-1.538 3.712l-4.773 4.773a5.21 5.21 0 0 1-3.711 1.54z"></path></svg></span></button></div></div></div><div><div class="generic-paragraph"><div class="generic-paragraph__text">Dr. Kleinhans received her B.A in psychology from the University of California, Berkeley and her Ph.D. in clinical psychology with a neuropsychology specialty from the University of California, San Diego. She received the Rennick award from the International Neuropsychological Society in 2005 and the award for “best neurobiological dissertation” at the International Meeting for Autism Research in 2006 for her doctoral work on the relationship among neurofunctional abnormalities, biochemical alterations, and language dysfunction in autism spectrum disorders. She completed a clinical neuropsychology internship at Brown University prior to joining the Autism Center and Department of Radiology as a Senior Fellow in 2005, under Drs. Elizabeth Aylward and Geraldine Dawson. Her major interests involve using multi-modal imaging technologies to investigate the neural basis of developmental disorders with a special focus on autism. <p><a href="https://rad.washington.edu/radiology-personnel/nkleinha/">Click here to learn more about Dr. Kleinhans</a>. <br></p></div></div></div> </section></div><div class="component-wrapper component-wrapper--all"><section class="generic-content" aria-label="Yale University - James McPartland, PhD"><div class="generic-content__title-container"><div class="heading__container"><h2 id="yale-university-james-mcpartland,-phd" class="generic-content__title">Yale University - James McPartland, PhD</h2><div class="generic-content__subtitle">Principal Investigator, Collaborating Implementation Site Co-Director</div><div class="heading__anchor-copy-button-container"><button type="button" aria-label="Copy Link" class="anchor-copy-button anchor-copy-button--color-mode--dark"><span class="anchor-copy-button__content"><span class="anchor-copy-button__text">Copy Link</span><svg xmlns="http://www.w3.org/2000/svg" xml:space="preserve" viewBox="0 0 24 24" focusable="false" class="anchor-copy-button__icon"><path d="M5.253 21.497a5.21 5.21 0 0 1-3.712-1.535A5.21 5.21 0 0 1 .006 16.25c0-1.404.545-2.722 1.535-3.712l4.773-4.774a5.22 5.22 0 0 1 3.716-1.539c1.402 0 2.719.544 3.708 1.531a5.225 5.225 0 0 1 .538 6.804.75.75 0 0 1-1.048.165.74.74 0 0 1-.299-.489.75.75 0 0 1 .134-.558 3.73 3.73 0 0 0-.384-4.86 3.73 3.73 0 0 0-2.649-1.094 3.73 3.73 0 0 0-2.655 1.099l-4.774 4.774a3.754 3.754 0 0 0 0 5.303c.707.707 1.649 1.096 2.652 1.096s1.945-.389 2.652-1.096l.932-.932a.744.744 0 0 1 1.06 0 .744.744 0 0 1 0 1.06l-.932.932a5.2 5.2 0 0 1-3.712 1.537"></path><path d="M13.978 18.024a5.21 5.21 0 0 1-3.709-1.535 5.22 5.22 0 0 1-.536-6.803.75.75 0 0 1 1.047-.166.75.75 0 0 1 .3.49.75.75 0 0 1-.134.558 3.73 3.73 0 0 0 .383 4.859 3.73 3.73 0 0 0 2.65 1.096 3.73 3.73 0 0 0 2.654-1.1l4.773-4.773c.708-.708 1.098-1.65 1.098-2.652s-.39-1.943-1.098-2.652c-.707-.707-1.649-1.096-2.652-1.096s-1.945.389-2.652 1.096l-.75.75a.744.744 0 0 1-1.06 0c-.142-.141-.22-.33-.22-.53s.078-.389.22-.53l.75-.75c.99-.99 2.309-1.536 3.712-1.536s2.722.545 3.712 1.536a5.21 5.21 0 0 1 1.538 3.712 5.21 5.21 0 0 1-1.538 3.712l-4.773 4.773a5.21 5.21 0 0 1-3.711 1.54z"></path></svg></span></button></div></div></div><div><div class="generic-paragraph"><div class="generic-paragraph__photo-container"><figure class="photo photo--medium floating-photo floating-photo--right"><div class="photo__image-container"><span class="" style="display:inline-block"></span></div><figcaption class="photo__details"><div class="photo__credit">Credit: Robert A. Lisak</div><div class="photo__caption-container"><div class="photo__caption">James McPartland, PhD <br /></div></div></figcaption></figure></div><div class="generic-paragraph__text"><p>As a clinical psychologist who directs the Yale Developmental Disabilities Clinic, James McPartland, Ph.D., spends a lot of time with patients with autism. He uses that experience as a neuroscientist to design experiments to understand how the brain works and how development of children with autism differs from typical development.</p> <p> <br> Dr. McPartland’s research is focused on understanding the way people with autism process social information by using electroencephalography (EEG) to detect electrical activity in the brain. He published the first study to show that people with autism process faces with decreased efficiency and has continued this work to examin autistic development before behavioral symptoms emerge in infants who have a higher risk for autism spectrum disorder (ASD). </p> <p> <br> One of the challenges in conducting this type of research is to create ways of measuring brain activity in real life social situations. Dr. McPartland has worked with Yale cognitive scientist Adam Naples, Ph.D., to create realistic avatars that respond to eye contact to show that there is a specific brain marker for eye contact, a new finding. A video game in which participants are rewarded for making eye contact at the appropriate time illustrates his efforts to not just understand brain activity, but also shape behavior. </p> <p> <br> The Autism Biomarkers Consortium for Clinical Trials is a large scale longitudinal multi-site research study based at Yale that spans Duke University, Boston Children’s Hospital, University of Washington/Seattle Children’s Research Institute and the University of California, Los Angeles. The network will develop a battery of electrophysiological, eye tracking, and behavioral tools to measure social function and communication in people with autism. </p> <p> <a href="https://medicine.yale.edu/childstudy/faculty/">Click here to learn more about Dr. McPartland</a> </p> <p> <a href="https://medicine.yale.edu/lab/mcpartland/">Click here to learn more about Dr. McPartland's research</a> </p></div></div></div> </section></div><div class="component-wrapper component-wrapper--all"><section class="generic-content" aria-label="Yale University - Katarzyna Chawarska, PhD"><div class="generic-content__title-container"><div class="heading__container"><h2 id="yale-university-katarzyna-chawarska,-phd" class="generic-content__title">Yale University - Katarzyna Chawarska, PhD</h2><div class="generic-content__subtitle">Collaborating Implementation Site Co-Director</div><div class="heading__anchor-copy-button-container"><button type="button" aria-label="Copy Link" class="anchor-copy-button anchor-copy-button--color-mode--dark"><span class="anchor-copy-button__content"><span class="anchor-copy-button__text">Copy Link</span><svg xmlns="http://www.w3.org/2000/svg" xml:space="preserve" viewBox="0 0 24 24" focusable="false" class="anchor-copy-button__icon"><path d="M5.253 21.497a5.21 5.21 0 0 1-3.712-1.535A5.21 5.21 0 0 1 .006 16.25c0-1.404.545-2.722 1.535-3.712l4.773-4.774a5.22 5.22 0 0 1 3.716-1.539c1.402 0 2.719.544 3.708 1.531a5.225 5.225 0 0 1 .538 6.804.75.75 0 0 1-1.048.165.74.74 0 0 1-.299-.489.75.75 0 0 1 .134-.558 3.73 3.73 0 0 0-.384-4.86 3.73 3.73 0 0 0-2.649-1.094 3.73 3.73 0 0 0-2.655 1.099l-4.774 4.774a3.754 3.754 0 0 0 0 5.303c.707.707 1.649 1.096 2.652 1.096s1.945-.389 2.652-1.096l.932-.932a.744.744 0 0 1 1.06 0 .744.744 0 0 1 0 1.06l-.932.932a5.2 5.2 0 0 1-3.712 1.537"></path><path d="M13.978 18.024a5.21 5.21 0 0 1-3.709-1.535 5.22 5.22 0 0 1-.536-6.803.75.75 0 0 1 1.047-.166.75.75 0 0 1 .3.49.75.75 0 0 1-.134.558 3.73 3.73 0 0 0 .383 4.859 3.73 3.73 0 0 0 2.65 1.096 3.73 3.73 0 0 0 2.654-1.1l4.773-4.773c.708-.708 1.098-1.65 1.098-2.652s-.39-1.943-1.098-2.652c-.707-.707-1.649-1.096-2.652-1.096s-1.945.389-2.652 1.096l-.75.75a.744.744 0 0 1-1.06 0c-.142-.141-.22-.33-.22-.53s.078-.389.22-.53l.75-.75c.99-.99 2.309-1.536 3.712-1.536s2.722.545 3.712 1.536a5.21 5.21 0 0 1 1.538 3.712 5.21 5.21 0 0 1-1.538 3.712l-4.773 4.773a5.21 5.21 0 0 1-3.711 1.54z"></path></svg></span></button></div></div></div><div><div class="generic-paragraph"><div class="generic-paragraph__photo-container"><figure class="photo photo--medium floating-photo floating-photo--right"><div class="photo__image-container"><span class="" style="display:inline-block"></span></div><figcaption class="photo__details"><div class="photo__credit">Credit: Robert A. Lisak</div><div class="photo__caption-container"><div class="photo__caption">Katarzyna Chawarska, PhD <br /></div></div></figcaption></figure></div><div class="generic-paragraph__text">Katarzyna Chawarska, PhD, is associate professor in the Yale Child Study Center and of Pediatrics. She directs theYale Toddler Developmental Disabilities Clinic and Yale Early Social Cognition Laboratory at the Child Study Center. Dr. Chawarska conducts clinical translational research focused on improving early diagnostic practices in ASD, understanding factors underlying heterogeneity of the syndrome expression, and developing novel measures for quantifying and stratifying complex autism-related phenotypes. This work has led to numerous publications on early behavioral, neurobehavioral, and biological markers of ASD and predictors of outcome into preschool and early school age both in infants at risk due to familial liability and clinic-referred toddlers. Work in her lab has focused on studying visual attention and its links with social disability in ASD. This work has demonstrated that deficits in social attention are particularly apparent in tasks relying on endogenous control of visual attention in response to complex social scenes. Such deficits are observed both during the prodromal and early syndromal stages of the disorders, suggesting a link with primary factors related to autism. Her group has also found that individual variation in the attention regulation patterns observed in the second year of life is predictive of clinical outcomes and can be useful for stratifying the affected toddlers into more homogenous clinically-relevant subgroups. Some of the candidate markers tasks being tested through the work of the Consortium have been developed in her lab. <br><br> To learn more about Dr. Chawarska <a href="https://medicine.yale.edu/childstudy/faculty/">click here.</a><br></div></div></div> </section></div></div></div></div><div class="sidebar page__sidebar-container"><div class="sidebar__sticky-container"></div></div></main><footer class="footer"><div class="footer__primary-panel-wrapper footer__primary-panel-wrapper--full-height"><div class="footer__content-container"><section class="footer__primary-panel" aria-label="Primary Links"><div class="desktop-footer-primary-panel"><div class="desktop-footer-primary-panel__organization-info-wrapper"><div class="footer-organization-info" role="presentation" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" aria-label="Yale School of Medicine" viewBox="0 0 384.2 29.1" focusable="false" class="site-wordmark__icon site-wordmark__icon--mode-ysm 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sites:</p>\r\n<ul>\r\n <li>Duke University</li>\r\n <li>Boston Children’s Hospital</li>\r\n <li>Children's Hospital Los Angeles </li>\r\n <li>University of Washington</li>\r\n <li>Yale University</li>\r\n</ul>\r\n<p>All of these sites are overseen by faculty members who are highly experienced in multi-site collaborative clinical research in children with ASD using the methods to be utilized for this project.\r\n<br></p>","photo":null,"imageLink":null,"photoMode":"medium","horizontalPhotoAlignment":"right","verticalPhotoAlignment":"top","textInset":{"heading":"","text":""}}],"relatedLinks":{"title":"Related Link","description":null,"items":[],"columnsCount":1},"metaData":{"title":"Collaborating Sites","description":"Data collection for the ABC-CT will take place across five sites:\r\r Duke University\r Boston Children’s Hospital\r Children's Hospital Los Angeles \r University of Washington\r Yale University\r\rAll of these sites are overseen by faculty members who are highly experienced 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Dr. Dawson is Professor of Psychiatry and Behavioral Sciences, Psychology, and Neuroscience and Director of the Duke Center for Autism and Brain Development at Duke University School of Medicine.  Her research focuses on recognizing and understanding the neural bases of the earliest manifestations of autism and early interventions that can improve outcomes. Her laboratory pioneered the use of electrophysiological measures with very young children with autism to study the brain basis of impairments in social and language development. She is an expert in the use of EEG measures to assess brain function in individuals with ASD and has been the PI on a NIH-funded randomized clinical trial that utilized EEG as an endpoint. She co-led the team that developed and empirically-validated the first behavioral intervention for infants and toddlers with autism (Early Start Denver Model). Dr. Dawson is currently Co-PI on a program of clinical trials research evaluating the efficacy of umbilical cord blood therapy for reducing core symptoms of ASD using eye-tracking and EEG as surrogate endpoints. She regularly collaborates with other autism researchers from a wide range of disciplines, ranging from genetics to animal models to community dissemination research.\r\n<br><br><a href=\"https://autismcenter.duke.edu/content/geraldine-dawson-phd\">Learn more about Dr. Dawson.</a><br>","photo":{"title":"","caption":"Geraldine Dawson, Ph.D.\r\n<br />","credit":null,"imageId":370396,"url":"https://res.cloudinary.com/ysm/image/upload/yms/prod/e80cbb0a-c0f8-4257-8eeb-c2ea75c85c6a","altText":"Geraldine Dawson, Ph.D. ","width":1200,"height":1800,"imageVariants":[]},"imageLink":null,"photoMode":"medium","horizontalPhotoAlignment":"right","verticalPhotoAlignment":"top","textInset":{"heading":"","text":""}}],"relatedLinks":{"title":"Related Link","description":null,"items":[],"columnsCount":1},"metaData":{"title":"Duke University - Geraldine Dawson, Ph.D.","description":"Geraldine Dawson, Ph.D., Duke Collaborating Implementation Site (CIS) Director. 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Dr. Dawson is currently Co-PI on a program of clinical trials research evaluating the efficacy of umbilical cord blood therapy for reducing core symptoms of ASD using eye-tracking and EEG as surrogate endpoints. She regularly collaborates with other autism researchers from a wide range of disciplines, ranging from genetics to animal models to community dissemination research.\rLearn more about Dr. Dawson.","imageMetaData":{"alt":"Geraldine Dawson, Ph.D. ","width":1200,"height":630,"url":"https://ysm-res.cloudinary.com/image/upload/c_limit,f_auto,h_630,q_auto,w_1200/v1/yms/prod/e80cbb0a-c0f8-4257-8eeb-c2ea75c85c6a","secureUrl":"https://ysm-res.cloudinary.com/image/upload/c_limit,f_auto,h_630,q_auto,w_1200/v1/yms/prod/e80cbb0a-c0f8-4257-8eeb-c2ea75c85c6a"},"videoMetaData":null,"audioMetaData":null,"author":null,"pageType":null,"publishDate":null,"canonicalUrl":null,"isNoIndex":false}}},{"key":"GenericContent","orderOnPage":6,"model":{"title":"Boston Children’s Hospital - Susan Faja, PhD","subtitle":"Collaborating Implementation Site Director, Director Clinical Workgroup","paragraphs":[{"heading":"","text":"<p>Dr. Faja studied Neuroscience at the University of Michigan before receiving her doctoral degree in Child Clinical Psychology from the University of Washington in 2009. She completed an internship at UCLA in the developmental disabilities track and postdoctoral fellowships focused on clinical neuroscience at the Children’s Hospital of Philadelphia and the University of Washington. Her research within the Laboratories of Cognitive Neuroscience investigates brain development and treatment response in clinical populations. In particular, she employs brain and behavioral measurement of social perception and executive control in children with autism spectrum disorder (ASD) and other neurodevelopmental disorders. A key focus of her work is translating existing training programs in the cognitive neuroscience literature for clinical use. An additional benefit of evaluating these interventions is the opportunity to directly test the plasticity of systems that have been implicated in the neurocognitive profile of ASD. She is also currently testing whether individual differences measured during cognitive tasks are meaningfully related to the social function and symptoms of young children with ASD and health outcomes of adults on the spectrum. By answering these questions, Dr. Faja will gain information about the risk factors and developmental sequences that are critical for development of ASD, other neurodevelopmental disorders, and typical development. In order to answer these questions, Dr. Faja’s lab seeks to improve the sensitivity of measurement used to capture the skills of individuals across a wide range of functioning.</p>\r\n<p>\r\n <a href=\"https://www.childrenshospital.org/directory/susan-faja\">Learn more about Susan Faja, PhD</a>\r\n</p>","photo":null,"imageLink":null,"photoMode":"small","horizontalPhotoAlignment":"right","verticalPhotoAlignment":"top","textInset":{"heading":"","text":""}}],"relatedLinks":{"title":"Related Link","description":null,"items":[],"columnsCount":1},"metaData":{"title":"Boston Children’s Hospital - Susan Faja, PhD","description":"Dr. Faja studied Neuroscience at the University of Michigan before receiving her doctoral degree in Child Clinical Psychology from the University of Washington in 2009. 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She is also currently testing whether individual differences measured during cognitive tasks are meaningfully related to the social function and symptoms of young children with ASD and health outcomes of adults on the spectrum. By answering these questions, Dr. Faja will gain information about the risk factors and developmental sequences that are critical for development of ASD, other neurodevelopmental disorders, and typical development. In order to answer these questions, Dr. Faja’s lab seeks to improve the sensitivity of measurement used to capture the skills of individuals across a wide range of functioning.\r\r Learn more about Susan Faja, PhD","imageMetaData":null,"videoMetaData":null,"audioMetaData":null,"author":null,"pageType":null,"publishDate":null,"canonicalUrl":null,"isNoIndex":false}}},{"key":"GenericContent","orderOnPage":8,"model":{"title":"CHLA - Shafali Jeste, MD","subtitle":"Collaborating Implementation Site Director","paragraphs":[{"heading":"","text":"<p>Dr. Jeste is a behavioral child neurologist specializing in autism and related neurodevelopmental disorders. She is Professor of Pediatrics and Neurology at the USC Keck School of Medicine, and the Las Madrinas Chair, Chief of Neurology and Co-Director of the Neurological Institute at CHLA. After earning a BA in philosophy from Yale University in 1997 and her MD from Harvard Medical School in 2002, Dr. Jeste completed a residency in child neurology and a fellowship in behavioral child neurology at Boston Children’s Hospital. She joined UCLA in 2010. Dr. Jeste’s research is focused on developing methods to improve precision in the diagnosis and treatment of neurodevelopmental disorders. Her lab studies neurodevelopmental disorders from early infancy through late childhood. Dr. Jeste has designed innovative studies in early predictors of autism in Tuberous Sclerosis Complex (TSC) that integrate biomarkers with behavior to define atypical development prior to the onset of autism. This work in TSC has led to the first randomized controlled clinical trial of behavioral intervention for these infants and has paved the way for other early intervention trials in rare genetic syndromes. Dr. Jeste’s research is directly inspired by her clinical work. To address the many gaps in medical care for rare genetic forms of neurodevelopmental disorders, she developed the Neurogenetics and Developmental Disabilities Clinic at CHLA. Dr. Jeste’s work is funded by the National Institutes of Health, the Department of Defense and the Simons Foundation. She holds several national and international leadership positions including the Board of Directors of the American Brain Foundation, Board of Directors of the National Organization for Rare Disorders, the Board of Directors of the International Society for Autism Research, and she recently served as the Chair of the International Baby Siblings Research Consortium. In 2019 she was awarded the Presidential Early Career Award for Scientists and Engineers for her innovations in research in early predictors and intervention for genetic neurodevelopmental disorders.  \r\n<br><br><a href=\"https://www.chla.org/kinddlab\">Click here to learn more about Dr. Jeste's Work</a>.\r\n<br></p>","photo":{"title":"","caption":"Shafali Jeste, MD\r\n<br />","credit":null,"imageId":378684,"url":"https://res.cloudinary.com/ysm/image/upload/yms/prod/203c39c8-3074-42d7-b584-9a9ef2ed35c1","altText":"Shafali Jeste, MD","width":1310,"height":1874,"imageVariants":[]},"imageLink":null,"photoMode":"small","horizontalPhotoAlignment":"right","verticalPhotoAlignment":"top","textInset":{"heading":"","text":""}}],"relatedLinks":{"title":"Related Link","description":null,"items":[],"columnsCount":1},"metaData":{"title":"CHLA - Shafali Jeste, MD","description":"Dr. Jeste is a behavioral child neurologist specializing in autism and related neurodevelopmental disorders. 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This work in TSC has led to the first randomized controlled clinical trial of behavioral intervention for these infants and has paved the way for other early intervention trials in rare genetic syndromes. Dr. Jeste’s research is directly inspired by her clinical work. To address the many gaps in medical care for rare genetic forms of neurodevelopmental disorders, she developed the Neurogenetics and Developmental Disabilities Clinic at CHLA. Dr. Jeste’s work is funded by the National Institutes of Health, the Department of Defense and the Simons Foundation. She holds several national and international leadership positions including the Board of Directors of the American Brain Foundation, Board of Directors of the National Organization for Rare Disorders, the Board of Directors of the International Society for Autism Research, and she recently served as the Chair of the International Baby Siblings Research Consortium. In 2019 she was awarded the Presidential Early Career Award for Scientists and Engineers for her innovations in research in early predictors and intervention for genetic neurodevelopmental disorders.  \rClick here to learn more about Dr. Jeste's Work.","imageMetaData":{"alt":"Shafali Jeste, MD","width":1310,"height":1874,"url":"https://ysm-res.cloudinary.com/image/upload/v1/yms/prod/203c39c8-3074-42d7-b584-9a9ef2ed35c1","secureUrl":"https://ysm-res.cloudinary.com/image/upload/v1/yms/prod/203c39c8-3074-42d7-b584-9a9ef2ed35c1"},"videoMetaData":null,"audioMetaData":null,"author":null,"pageType":null,"publishDate":null,"canonicalUrl":null,"isNoIndex":false}}},{"key":"GenericContent","orderOnPage":10,"model":{"title":"University of Washington - Natalia Kleinhans, PhD ","subtitle":"Collaborating Implementation Site Director","paragraphs":[{"heading":"","text":"Dr. Kleinhans received her B.A in psychology from the University of California, Berkeley and her Ph.D. in clinical psychology with a neuropsychology specialty from the University of California, San Diego. She received the Rennick award from the International Neuropsychological Society in 2005 and the award for “best neurobiological dissertation” at the International Meeting for Autism Research in 2006 for her doctoral work on the relationship among neurofunctional abnormalities, biochemical alterations, and language dysfunction in autism spectrum disorders. She completed a clinical neuropsychology internship at Brown University prior to joining the Autism Center and Department of Radiology as a Senior Fellow in 2005, under Drs. Elizabeth Aylward and Geraldine Dawson. Her major interests involve using multi-modal imaging technologies to investigate the neural basis of developmental disorders with a special focus on autism.\r\n<p><a href=\"https://rad.washington.edu/radiology-personnel/nkleinha/\">Click here to learn more about Dr. Kleinhans</a>.\r\n<br></p>","photo":null,"imageLink":null,"photoMode":"medium","horizontalPhotoAlignment":"right","verticalPhotoAlignment":"top","textInset":{"heading":"","text":""}}],"relatedLinks":{"title":"Related Link","description":null,"items":[],"columnsCount":1},"metaData":{"title":"University of Washington - Natalia Kleinhans, PhD ","description":"Dr. Kleinhans received her B.A in psychology from the University of California, Berkeley and her Ph.D. in clinical psychology with a neuropsychology specialty from the University of California, San Diego. 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Her major interests involve using multi-modal imaging technologies to investigate the neural basis of developmental disorders with a special focus on autism.\rClick here to learn more about Dr. Kleinhans.","imageMetaData":null,"videoMetaData":null,"audioMetaData":null,"author":null,"pageType":null,"publishDate":null,"canonicalUrl":null,"isNoIndex":false}}},{"key":"GenericContent","orderOnPage":12,"model":{"title":"Yale University - James McPartland, PhD","subtitle":"Principal Investigator, Collaborating Implementation Site Co-Director","paragraphs":[{"heading":"","text":"<p>As a clinical psychologist who directs the Yale Developmental Disabilities Clinic, James McPartland, Ph.D., spends a lot of time with patients with autism. He uses that experience as a neuroscientist to design experiments to understand how the brain works and how development of children with autism differs from typical development.</p>\r\n<p>\r\n <br>\r\nDr. McPartland’s research is focused on understanding the way people with autism process social information by using electroencephalography (EEG) to detect electrical activity in the brain. He published the first study to show that people with autism process faces with decreased efficiency and has continued this work to examin autistic development before behavioral symptoms emerge in infants who have a higher risk for autism spectrum disorder (ASD). </p>\r\n<p>\r\n <br>\r\nOne of the challenges in conducting this type of research is to create ways of measuring brain activity in real life social situations. Dr. McPartland has worked with Yale cognitive scientist Adam Naples, Ph.D., to create realistic avatars that respond to eye contact to show that there is a specific brain marker for eye contact, a new finding.  A video game in which participants are rewarded for making eye contact at the appropriate time illustrates his efforts to not just understand brain activity, but also shape behavior. </p>\r\n<p>\r\n <br>\r\nThe Autism Biomarkers Consortium for Clinical Trials is a large scale longitudinal multi-site research study based at Yale that spans Duke University, Boston Children’s Hospital, University of Washington/Seattle Children’s Research Institute and the University of California, Los Angeles. The network will develop a battery of electrophysiological, eye tracking, and behavioral tools to measure social function and communication in people with autism. </p>\r\n<p>\r\n <a href=\"https://medicine.yale.edu/childstudy/faculty/\">Click here to learn more about Dr. McPartland</a>\r\n</p>\r\n<p>\r\n <a href=\"https://medicine.yale.edu/lab/mcpartland/\">Click here to learn more about Dr. McPartland's research</a>\r\n</p>","photo":{"title":"","caption":"James McPartland, PhD\r\n<br />","credit":"Robert A. 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He uses that experience as a neuroscientist to design experiments to understand how the brain works and how development of children with autism differs from typical development.\r\r \rDr. McPartland’s research is focused on understanding the way people with autism process social information by using electroencephalography (EEG) to detect electrical activity in the brain. He published the first study to show that people with autism process faces with decreased efficiency and has continued this work to examin autistic development before behavioral symptoms emerge in infants who have a higher risk for autism spectrum disorder (ASD). \r\r \rOne of the challenges in conducting this type of research is to create ways of measuring brain activity in real life social situations. Dr. McPartland has worked with Yale cognitive scientist Adam Naples, Ph.D., to create realistic avatars that respond to eye contact to show that there is a specific brain marker for eye contact, a new finding.  A video game in which participants are rewarded for making eye contact at the appropriate time illustrates his efforts to not just understand brain activity, but also shape behavior. \r\r \rThe Autism Biomarkers Consortium for Clinical Trials is a large scale longitudinal multi-site research study based at Yale that spans Duke University, Boston Children’s Hospital, University of Washington/Seattle Children’s Research Institute and the University of California, Los Angeles. 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