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<!DOCTYPE html> <html lang="en"> <head> <meta charset="utf-8"> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="viewport" content="width=device-width, initial-scale=1"> <meta http-equiv="X-UA-Compatible" content="IE=edge" /> <meta name="robots" content="index,follow" /> <meta name="googlebot" content="index,follow" /> <meta name="google-site-verification" content="aWjBPIhV1_Yepr3NGd5e26QXEKfSzvcxEFB44G1o03U" /> <link rel="shortcut icon" href="https://www.imedpub.com/images/favicon.ico" /> <link rel="canonical" href="https://clinical-and-molecular-endocrinology.imedpub.com/" /> <link rel="alternate" href="https://clinical-and-molecular-endocrinology.imedpub.com//abstract/thyroid-dysfunction-induced-by-immune-checkpoint-inhibitors-44897.html" hreflang="en-us" />  <link rel="stylesheet" href="https://use.fontawesome.com/releases/v5.3.1/css/all.css" /> <link href="https://fonts.googleapis.com/css?family=Open+Sans:300,300i,400,400i,600,600i,700,700i,800,800i&display=swap" rel="stylesheet" /> <link rel="stylesheet" href="https://www.imedpub.com/assets/css/imedpub_com.css" /> <link rel="stylesheet" href="https://www.imedpub.com/assets/css/global.css" /> <link rel="stylesheet" href="https://www.imedpub.com/assets/css/author.css" /> <link href="https://www.imedpub.com/css/imed_external_style.css" rel="stylesheet" type="text/css" /> <link href="https://www.imedpub.com/css/styles.css" rel="stylesheet" type="text/css" /> <link href='https://fonts.googleapis.com/css?family=Open+Sans' rel='stylesheet' type='text/css' />   <script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script> <script src="https://ajax.googleapis.com/ajax/libs/jquery/1.11.1/jquery.min.js"></script>      <script src="https://maxcdn.bootstrapcdn.com/bootstrap/3.3.4/js/bootstrap.min.js"></script>  <script async src="https://www.googletagmanager.com/gtag/js?id=G-89LSBGR20Z"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-89LSBGR20Z'); </script> <script type="application/ld+json"> { "@context": "https://schema.org", "@type": "Organization", "url": "https://clinical-and-molecular-endocrinology.imedpub.com/", "logo": "https://www.imedpub.com/images/imedpub-logo.png" } </script> <style> p { text-align:justify !important; } </style><title>Thyroid Dysfunction Induced By Immune Check-Point Inhibitors | Abstract</title> <meta name="keywords" content=", Immunotherapy, Antibodies, Malignant, thyroid, Prevents"/> <meta name="description" content="The immune system is the core defense against cancer development and progression. Failure of the immune system to recognize and eliminate malignant ce.. "/> <meta name="citation_publisher" content="iMedPub" /> <meta name="citation_journal_title" content="Journal of Clinical and Molecular Endocrinology"> <meta name="citation_title" content="Thyroid Dysfunction Induced By Immune Check-Point Inhibitors"> <meta name="citation_author" content="" /> <meta name="citation_month" content="February"> <meta name="citation_year" content="2021"> <meta name="citation_volume" content="6"> <meta name="citation_issue" content="1"> <meta name="citation_issn" content=" 2572-5432"> <meta name="citation_online_date" content="2022/03/30" /> <meta name="citation_abstract" content="The immune system is the core defense against cancer development and progression. Failure of the immune system to recognize and eliminate malignant cells plays an immense role in the pathogenesis of cancer. The paramount achievement in immunotherapy particularly Immune Checkpoint Inhibitors (ICI) over the recent decade has brought about a major paradigm shifts i n cancer treatment. ICIs represented mainly by inhibitory monoclonal antibodies Anti-cytotoxic T-lymphocyte Antigen4 (CTLA-4) (ipilimumab), anti-programmed cell death protein 1 (PD-1- pembrolizumab/nivolumab/cemiplimab), Anti-PD-1 Ligand molecules (PD-L-1-atezolizumab/avelumab/durvalumab) reactivate the immune system against tumor c ells but can also trigger a myriad of autoimmune side effects, termed immune-related Adverse Events (irAEs). Immunotherapy related adverse events typically have a delayed onset and prolonged duration compared to adverse events from chemotherapy, and its effective management depends on early recognition and prompt intervention with immune suppression and/or immunomodulatory strategies. The present review aims to raise awareness about the thyroid side effects of immune checkpoint inhibitors to physicians who are taking care of cancer patients and to specialists-mainly oncologists and endocrinologists who are urged to cooperate for the management of thyroid immunotoxicity."> <meta name="citation_fulltext_html_url" content="https://clinical-and-molecular-endocrinology.imedpub.com/articles/thyroid-dysfunction-induced-by-immune-checkpoint-inhibitors.php?aid=44897"> <meta name="citation_pdf_url" content="https://clinical-and-molecular-endocrinology.imedpub.com/articles/thyroid-dysfunction-induced-by-immune-checkpoint-inhibitors.pdf"> <meta name="citation_abstract_html_url" content="https://clinical-and-molecular-endocrinology.imedpub.com/abstract/thyroid-dysfunction-induced-by-immune-checkpoint-inhibitors-44897.html"> </head> <body> <div class="container-fluid"> <div class="container container_bg">  <header class="row justify-content-between align-items-center px-3"> <div 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Failure of the immune system to recognize and eliminate malignant cells plays an immense role in the pathogenesis of cancer. The paramount achievement in immunotherapy particularly Immune Checkpoint Inhibitors (ICI) over the recent decade has brought about a major paradigm shifts i n cancer treatment.</p> <p>ICIs represented mainly by inhibitory monoclonal antibodies Anti-cytotoxic T-lymphocyte Antigen4 (CTLA-4) (ipilimumab), anti-programmed cell death protein 1 (PD-1- pembrolizumab/nivolumab/cemiplimab), Anti-PD-1 Ligand molecules (PD-L-1-atezolizumab/avelumab/durvalumab) reactivate the immune system against tumor c ells but can also trigger a myriad of autoimmune side effects, termed immune-related Adverse Events (irAEs). Immunotherapy related adverse events typically have a delayed onset and prolonged duration compared to adverse events from chemotherapy, and its effective management depends on early recognition and prompt intervention with immune suppression and/or immunomodulatory strategies.</p> <p>The present review aims to raise awareness about the thyroid side effects of immune checkpoint inhibitors to physicians who are taking care of cancer patients and to specialists-mainly oncologists and endocrinologists who are urged to cooperate for the management of thyroid immunotoxicity.</p><br /> <strong>Author(s):</strong> <br /> <a href="https://clinical-and-molecular-endocrinology.imedpub.com/articles/thyroid-dysfunction-induced-by-immune-checkpoint-inhibitors.php?aid=44897" title="Thyroid Dysfunction Induced By Immune Check-Point Inhibitors"></a><br /> <a href="https://clinical-and-molecular-endocrinology.imedpub.com/abstract/thyroid-dysfunction-induced-by-immune-checkpoint-inhibitors-44897.html" 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