CINXE.COM

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "pubs.acs.org",cType: 'managed',cRay: '9133b872ad963fe0',cH: 'KXSS1mev34RzefzHLI_uIjBEkzPjf6CPXHQ5YBs2f1o-1739773739-1.2.1.1-JP877rZyuc7r9KWz3VtSYpanoLu9EvSYPDdBtPDFLV1TJi9C_zy0uvBJjIh_2YD9',cUPMDTk: "\/doi\/10.1021\/acs.jmedchem.0c00297?__cf_chl_tk=WqrMWoC7oxbiIps.TYLRB20yssr9MAmguCjsN9Y9_qk-1739773739-1.0.1.1-Vpv7IRlckssgOtWwrM.jpv0TscvvdekThj411aXd83U",cFPWv: 'b',cITimeS: '1739773739',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/doi\/10.1021\/acs.jmedchem.0c00297?__cf_chl_f_tk=WqrMWoC7oxbiIps.TYLRB20yssr9MAmguCjsN9Y9_qk-1739773739-1.0.1.1-Vpv7IRlckssgOtWwrM.jpv0TscvvdekThj411aXd83U",md: "6r47bC_CilrXafkfhx14nOkWyhDYtONbfhvKbXiqBGY-1739773739-1.2.1.1-7UA56QqMMO2hyyuehJRdkBiWZHtRG95hV.hTqBX2tF_PCc8YeE2446ZCXI4x.Lf.U5sLqDnn9_ViyKHa6CIviRTQ41oTzPiCrwXqwWFUZdU3VcN9hVAICFimpk6DH1qqH0Py_Hu.Zxc0ZDdH0f211RqiQkZH5d7PolslPJ3zRDCGy_WoJO2poQ9OysYivQ6ovZbvcGAlzLwBF01bjsLMJMijWQurvuyr7XV39ppFL6dA_9T1zhzhGg1oBC3cM3PA.kPTFZw9f5QD099rVupsTzssU.EHQw.3YcKIoKp2BMiR8j6zlg4GDVBB30RGPUv5iKnMPWAhpxjqZp.ttiXJvou5ZqOj3cvaDiBebvhcqClGwaSfmClB1HbtjAesLY53h63QoO6vPJtrg.idejElj8sIpHfC_3welI__ZYPQ9Z5OoINCuu4Yu4touHR_Ur8x2FFUHnpeAy52AvNilI6Sdz8l_8rHxSelwPDa27KjxaNZtYZUVPjf3CuV9JrRjpTpuVtLB.c14gOLsbEhYgRGfRUCqx55yc_Dw0QkHUtujPO8hr649gp7d5eEjq6EoETy7PFznT7igdbeCKF7ET_NOLtOrwirn5JpFGr2ennXrwVG_09nkkkwgODXT94oP2Qoyr8C5aJcy0XF2wBI0AoofOpyVPVjciRdolTCLiY6aXg_KkrsQcsi2ehpuths7wBphuWKRQ72snkzCQe48FgxB2AMa6wiHpCtbOZTFKqoo24hlyUPvhfN5phlx1J53q3ao1PyCcEuTXTjbVwlLZdOiZUCbFIN3nW._VJ7.ZvrF_oEgA1YpCD2C5ft_xowxwZscryE0a20K6zAc2SFd90WfBmAR1OEZbGV7Ka9x8YfVWzQCigUtoqzelYbotA9fBVdwQfyfQqA3lkaIylb3hjFLyN6CqaxzGjh9y9y6PRZ5ZhrC1WyrbrEGXRgIUJodU6xfY6FtYUuYDy2lkcjiyq5HHCL9nezLZzqNRijIic0NATcn8cep2ASjD8i.zEnbjwFnaEU.m5vUArH6B6cO7_BaboBuVb3fuJkngMEuXrn9wRZopsx8yqzOrLObumF0T0ZVHSfD.Zl30mDqbI6elfPr.4CXnRHuO2cxx4XOg4eb_RkZ4ImwKbUKYe2WDjIngT7.itMLou8cw.3ky8QZoyrpodocWYMADyaSMA2vWlvZ69TGrybPzcTS.8DMl5j.5o6JiFvSFcPIMGpAF7K44EDqsBWsDhk.W9G6B59h44TXoeqfyqtS3l3y4WTzv08uhD58qT4iBgkWoiolRyf0s9spHW5GwQ0BsFEr3bTvKd1Gw1O6dTlSncmcLC8__WvGhHYH4sKVVhAz8.n0Kh6YRE2KKCd79X_ugDNtVN0iiWbcwF4yciDptrNn9d55bKAt8oxRdFtTj0SM3veFiFfqntkVL94WRm1HSAvdSDzolaBIWSeMNv7oDQXu2NfPIn6CEx7loWvDg57y3Uo7qbXRmNXVKbHkIB9IcFpZ7m3C7iTQ5OHnrnTiyGYS1PizgZB0z7Xzq3.VTpmfpt_nrSl3kGsFqOBKpkaNygwAfPuMfddUVi16cbPLYFffuhvMoDYLuQwlpDs4OYjCHkzaz1dqDzPJtJLzPHIR6LuKDT93sEr.D7oTWorAU6KbXDKPNqVVl_hpjn88GL0ONuUL7NsUOiAcieobEmS1bxKipU2zqpaEZ5Y78aqyIVUgd1gGjJw6ZfYgLWM5yaJgcBZv.TnxoQlHc9dVJe6wXrF3tFOHUibRikdQIgoewjh2n8Vy6wdQE.DYFg3iUbeO2kvno76HRRmEFJ1vCzUnz_VdHT2cFUUZ886QbXAVyvGr3K0Ao_7HVyoqLb9piXFvgIn16ySpfIz_7r7_jgnIKbFL4cryECAMqcyUV_81fZfpyWBZcyAJxUquD3WHdvKq5oik0bGmB8cE2jB1lOv7smdS66mUT5wV3bDXtTM7kTF2q.OaLqpU2Ag_L2RnGK.Zm_LcTeByRIs4YQVeanV_2_cap3_VTXFB.WR84Hs10v9exYqet660jCRhru9Hj9KatoAWxFAvZTAVhe3ZjvvCBTxkqqUTtl4XXaUc6NzECVE9tt3Wx7jvJRRs6PKLtrJjJWfd7e76ShdaQugI9ATQTZmmFpNTHFVVieAreQc0Ig4.YcTb8VtMllj05pc0Q9YiLsvmiR8oPj48Cop9P1rc5crLOYz1WAf1mkJ8askA0hTG_dhWzbbekfWiS94VAlKLCuGVZdODslBrGZfjyBlQy4rdn5goV.uRcWGG1focok1UAhR7wX5Io628G5Q_UVW8XN.5ImuZ95WeH8LBT3bZU9zj9paJpPOAaudixHyU9DyVDstXJo0n_H4R_FNrNmaauAfkWdpl.I4HVbZTwJkHCs7omwF0h684PRWxPjyA8jZg1_73.rPnWixsGAZbky3a6YpdPlomeGb.xgKMijikjsSGrfmrLJ788TmPQzojGaINMG8zYsOOK9kQ2pPhAHTpax2auUDpQXFc9SOCPaQvEClDwUW2UqL_lr1ZbiNCUNVdq6NPef21t2iKZAcScu95KX9CcA6hIF.2NAumvlQk6mExLXsGUy0zfM",mdrd: "WvOJ4LuMPaf9EicqBpuudGbcY2OOiKtO7PwKYgqYpoE-1739773739-1.2.1.1-H1a1Jigu7atPVO8GLeQTofjbc_V7EqjNgBUtrfu6UnVkXy3r3gqlTEu.hO.1Y5gikn_Q5FAUpBfmY4Qgy0_x3E909tXvRhlMwQJoojV_.QJBcp8n8GrjLsk.WHr_fVUqrSMz1ggAmLT6UfS2evm2ZrCdK91yvsfLukiFUX5M3G0IqVKaXS4Z56wNyUXUjpsxG3Gv0IL.0LWTPHdkZa8cB8hBrH332DXqAd4T.RGwTubHDbBAgu7KDY_QjGgesoidV4pE1XnpVvDoic67MoTPCR0d0Da5QhbUyyUf7SLRfFeAqMJNhMa5xccmhrOUZF.FoDUdwvUGMkGxgwlDbQUKeE_mKlxSUAMC6HRgbdPVS_qOEsmL_X5ZDtS0WE8heB3Ig8o_psjwoebDSh2bnUN8xvzI4.OKfKryAHnuLdPna5ZWOp41UBMjmGHvpAZK._37UCDQk1dRY_788W1wUFXM3U8TN0ME0qfKzDLMHhL8_KpEWE91KAdxrvIlnzEPZh7Ff_5.3cdLOpX5vSDNwu1ecH5U6vXLbK6nqd1fy2XxadUKuCEIUW6jhfPl3ua.nLj_IC_g.St9WHDV8HeP4OP7nvsDWglQBZEH.rbe7OMCU_vXiVoVIIvQaVcS5KJTxzm8afGfYclCOM9Dui2AfFbehDFVf45H.m.fYkks7Qtdb3BCROm9haALrIdeZrq0pLd1nPQlxMa22kms7h7SyCPysr6gkxyb5zOt1LR2vNaM0fiuJgME15S.Ouro66Epo4CxqK4g4gmMqQ8Srk91lNTXXvnBaHKhCwCKMTsU9V9vSsqzwJKZ05vQanmfn8IjmWc5jshkcx8MFd7zqsGEm6P.9qp9KYj.LUOYMenlTofc3xFOo.yqsJLB31aupzbJKQWQ5DtJOBuyexJ9WRJ_VLHTuTHfgs0aI3GIw8Fyvi3a3H3J8SwenJnlA.j0MgBiSHIXyyFmTdcBKrM0gkc7CMTcD1giGSCz.w4F556KPzPbzwy8VenAXhqb15tNB7rw4jFKmrd6CGowgTzJPZeBIxibN9YqnOhDnLb9FjZKW9j0jGOipHP3xZyS65A9jTkNcZNQJ07rad1eRS2cVpiV1DyKVSptPCBrBe6OjnR0mfwpAbguQPc56hza1vnkEabm_nh_obn7mFULiCdZhjKCP_bkIv1G4PRXldF63QoRWj6M8I48rkou3GXI0b9PH9rSrna1Hau8JOaS1nHsGJnx6ycMA5E_2HHtSY2ohK_bhoMsJG_3LipbqULwJRHb_Ef0MNYxCYC4gKTHJ9S3NZRLtd._HjP_8mSvYkyIn1OE6oER5mMD18tS.dir7mqGo2Pjyv9ZWRAXbB8CkGkNUnRBWEM4CWOXdjw_O0N36ztlSTqC0n7Orq0qV696Fry8Rqpq_APgTD3HXl3xiM7ECjP5LIrEXF2.g9PuTEP7iNot.ORZmLG4pYkvyHc16B7mANZ.jmEGaHLQTOKCxWuL7MKzvejiZromtQifj9z4f8Wy53ESzAMItEKDhErtKeeP0HJo5cixET7ROcA53G.Ye0g.TWNJQnd9ID6NMZjIoOPq6EvTJHtFGuQPBnMagcvnUiUasQzoez259DkT9s1l_8sENPzLsITlshmo9eQFLXcOJ9H9g5voeT8cUdaB4spfpV.ufmXOkYNSZtxe3pow5bNyoob05Iy7nCZHJnovnIPV_175.h6h3U1pGTywtc7x4d832d5J6bPwcVjJw63vCYH93ub5oZ7acdhxWIDhIIGJzfw5imzzYRcSwcc8yCEAUi_TRjFXTYuJlmw_4RT49im1PNrk61Iz4FZ3O6lNLOXr0Oa5jwt75XGgoNZPwjwuF.ggexbWqzzhVas9B8EmbcTG8uP7slhMPOsBOteNN0uRUvEedQcaxxRPts6Xhv0LTs3d3kstUUa9I_XTsUQO2p4JUnFMI8EdylFgY5pq7J0TpI0Y6Bc"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/b/orchestrate/chl_page/v1?ray=9133b872ad963fe0';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/doi\/10.1021\/acs.jmedchem.0c00297?__cf_chl_rt_tk=WqrMWoC7oxbiIps.TYLRB20yssr9MAmguCjsN9Y9_qk-1739773739-1.0.1.1-Vpv7IRlckssgOtWwrM.jpv0TscvvdekThj411aXd83U" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>