An Analytical Study on the Effect of Chronic Liver Disease Severity and Etiology on Lipid Profiles

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Effect of Chronic Liver Disease Severity and Etiology on Lipid Profiles</title> <meta name="description" content="An Analytical Study on the Effect of Chronic Liver Disease Severity and Etiology on Lipid Profiles"> <meta name="keywords" content="CLD, cholesterol, HDL, LDL, lipid profile, triglycerides, VLDL"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img 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publication-listing mt-3 mb-3"> <h5 class="card-header" style="font-size:.9rem">An Analytical Study on the Effect of Chronic Liver Disease Severity and Etiology on Lipid Profiles</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Thinakar%20Mani%20Balusamy">Thinakar Mani Balusamy</a>, <a href="https://publications.waset.org/abstracts/search?q=Venkateswaran%20A.%20R."> Venkateswaran A. R.</a>, <a href="https://publications.waset.org/abstracts/search?q=Bharat%20Narasimhan"> Bharat Narasimhan</a>, <a href="https://publications.waset.org/abstracts/search?q=Ratnakar%20Kini%20S."> Ratnakar Kini S.</a>, <a href="https://publications.waset.org/abstracts/search?q=Kani%20Sheikh%20M."> Kani Sheikh M.</a>, <a href="https://publications.waset.org/abstracts/search?q=Prem%20Kumar%20K."> Prem Kumar K.</a>, <a href="https://publications.waset.org/abstracts/search?q=Pugazhendi%20Thangavelu"> Pugazhendi Thangavelu</a>, <a href="https://publications.waset.org/abstracts/search?q=Arun%20Murugan"> Arun Murugan</a>, <a href="https://publications.waset.org/abstracts/search?q=Sibi%20Thooran%20Karmegam"> Sibi Thooran Karmegam</a>, <a href="https://publications.waset.org/abstracts/search?q=Radhakrishnan%20N."> Radhakrishnan N.</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammed%20Noufal"> Mohammed Noufal</a>, <a href="https://publications.waset.org/abstracts/search?q=Amit%20Soni"> Amit Soni</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background and Aims: The liver is integral to lipid metabolism, and a compromise in its function leads to perturbations in these pathways. In this study, we hope to determine the correlation between CLD severity and its effect on lipid parameters. We also look at the etiology-specific effects on lipid levels. Materials and Methods: This is a retrospective cross-sectional analysis of 250 patients with cirrhosis compared to 250 healthy age and sex-matched controls. Severity assessment of CLD using MELD and Child-Pugh scores was performed and etiological details collected. A questionnaire was used to obtain patient demographic details and lastly, a fasting lipid profile (Total, LDL, HDL cholesterol, Triglycerides and VLDL) was obtained. Results: All components of the lipid profile declined linearly with increasing severity of CLD as determined by MELD and Child-Pugh scores. Lipid levels were clearly lower in CLD patients as compared to healthy controls. Interestingly, preliminary analysis indicated that CLD of different etiologies had differential effects on Lipid profiles. This aspect is under further analysis. Conclusion: All components of the lipid profile were definitely lower in CLD patients as compared to controls and demonstrated an inverse correlation with increasing severity. The utilization of this parameter as a prognosticating aid requires further study. Additionally, preliminary analysis indicates that various CLD etiologies appear to have specific effects on the lipid profile – a finding under further analysis. <iframe src="https://publications.waset.org/abstracts/81615.pdf" style="width:100%; height:400px;" frameborder="0"></iframe> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=CLD" title="CLD">CLD</a>, <a href="https://publications.waset.org/abstracts/search?q=cholesterol" title=" cholesterol"> cholesterol</a>, <a href="https://publications.waset.org/abstracts/search?q=HDL" title=" HDL"> HDL</a>, <a href="https://publications.waset.org/abstracts/search?q=LDL" title=" LDL"> LDL</a>, <a href="https://publications.waset.org/abstracts/search?q=lipid%20profile" title=" lipid profile"> lipid profile</a>, <a href="https://publications.waset.org/abstracts/search?q=triglycerides" title=" triglycerides"> triglycerides</a>, <a href="https://publications.waset.org/abstracts/search?q=VLDL" title=" VLDL"> VLDL</a> </p> <a href="https://publications.waset.org/abstracts/81615/an-analytical-study-on-the-effect-of-chronic-liver-disease-severity-and-etiology-on-lipid-profiles" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/81615.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">220</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" 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An Analytical Study on the Effect of Chronic Liver Disease Severity and Etiology on Lipid Profiles