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format('woff2'); unicode-range: U+0460-052F, U+1C80-1C8A, U+20B4, U+2DE0-2DFF, U+A640-A69F, U+FE2E-FE2F; } /* cyrillic */ @font-face { font-family: 'Merriweather'; font-style: italic; font-weight: 400; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4m0qyriQwlOrhSvowK_l5-eRZKf-LHrw.woff2) format('woff2'); unicode-range: U+0301, U+0400-045F, U+0490-0491, U+04B0-04B1, U+2116; } /* vietnamese */ @font-face { font-family: 'Merriweather'; font-style: italic; font-weight: 400; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4m0qyriQwlOrhSvowK_l5-eRZBf-LHrw.woff2) format('woff2'); unicode-range: U+0102-0103, U+0110-0111, U+0128-0129, U+0168-0169, U+01A0-01A1, U+01AF-01B0, U+0300-0301, U+0303-0304, U+0308-0309, U+0323, U+0329, U+1EA0-1EF9, U+20AB; } /* latin-ext */ @font-face { font-family: 'Merriweather'; font-style: italic; font-weight: 400; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4m0qyriQwlOrhSvowK_l5-eRZAf-LHrw.woff2) format('woff2'); unicode-range: U+0100-02BA, U+02BD-02C5, U+02C7-02CC, U+02CE-02D7, U+02DD-02FF, U+0304, U+0308, U+0329, U+1D00-1DBF, U+1E00-1E9F, U+1EF2-1EFF, U+2020, U+20A0-20AB, U+20AD-20C0, U+2113, U+2C60-2C7F, U+A720-A7FF; } /* latin */ @font-face { font-family: 'Merriweather'; font-style: italic; font-weight: 400; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4m0qyriQwlOrhSvowK_l5-eRZOf-I.woff2) format('woff2'); unicode-range: U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD; } /* cyrillic-ext */ @font-face { font-family: 'Merriweather'; font-style: italic; font-weight: 700; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4l0qyriQwlOrhSvowK_l5-eR71Wvf1jvzRPA.woff2) format('woff2'); unicode-range: U+0460-052F, U+1C80-1C8A, U+20B4, U+2DE0-2DFF, U+A640-A69F, U+FE2E-FE2F; } /* cyrillic */ @font-face { font-family: 'Merriweather'; font-style: italic; font-weight: 700; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4l0qyriQwlOrhSvowK_l5-eR71Wvf8jvzRPA.woff2) format('woff2'); unicode-range: U+0301, U+0400-045F, U+0490-0491, U+04B0-04B1, U+2116; } /* vietnamese */ @font-face { font-family: 'Merriweather'; font-style: italic; font-weight: 700; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4l0qyriQwlOrhSvowK_l5-eR71Wvf3jvzRPA.woff2) format('woff2'); unicode-range: U+0102-0103, U+0110-0111, U+0128-0129, U+0168-0169, U+01A0-01A1, U+01AF-01B0, U+0300-0301, U+0303-0304, U+0308-0309, U+0323, U+0329, U+1EA0-1EF9, U+20AB; } /* latin-ext */ @font-face { font-family: 'Merriweather'; font-style: italic; font-weight: 700; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4l0qyriQwlOrhSvowK_l5-eR71Wvf2jvzRPA.woff2) format('woff2'); unicode-range: U+0100-02BA, U+02BD-02C5, U+02C7-02CC, U+02CE-02D7, U+02DD-02FF, U+0304, U+0308, U+0329, U+1D00-1DBF, U+1E00-1E9F, U+1EF2-1EFF, U+2020, U+20A0-20AB, U+20AD-20C0, U+2113, U+2C60-2C7F, U+A720-A7FF; } /* latin */ @font-face { font-family: 'Merriweather'; font-style: italic; font-weight: 700; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4l0qyriQwlOrhSvowK_l5-eR71Wvf4jvw.woff2) format('woff2'); unicode-range: U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD; } /* cyrillic-ext */ @font-face { font-family: 'Merriweather'; font-style: italic; font-weight: 900; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4l0qyriQwlOrhSvowK_l5-eR7NWPf1jvzRPA.woff2) format('woff2'); unicode-range: U+0460-052F, U+1C80-1C8A, U+20B4, U+2DE0-2DFF, U+A640-A69F, U+FE2E-FE2F; } /* cyrillic */ @font-face { font-family: 'Merriweather'; font-style: italic; font-weight: 900; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4l0qyriQwlOrhSvowK_l5-eR7NWPf8jvzRPA.woff2) format('woff2'); unicode-range: U+0301, U+0400-045F, U+0490-0491, U+04B0-04B1, U+2116; } /* vietnamese */ @font-face { font-family: 'Merriweather'; font-style: italic; font-weight: 900; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4l0qyriQwlOrhSvowK_l5-eR7NWPf3jvzRPA.woff2) format('woff2'); unicode-range: U+0102-0103, U+0110-0111, U+0128-0129, U+0168-0169, U+01A0-01A1, U+01AF-01B0, U+0300-0301, U+0303-0304, U+0308-0309, U+0323, U+0329, U+1EA0-1EF9, U+20AB; } /* latin-ext */ @font-face { font-family: 'Merriweather'; font-style: italic; font-weight: 900; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4l0qyriQwlOrhSvowK_l5-eR7NWPf2jvzRPA.woff2) format('woff2'); unicode-range: U+0100-02BA, U+02BD-02C5, U+02C7-02CC, U+02CE-02D7, U+02DD-02FF, U+0304, U+0308, U+0329, U+1D00-1DBF, U+1E00-1E9F, U+1EF2-1EFF, U+2020, U+20A0-20AB, U+20AD-20C0, U+2113, U+2C60-2C7F, U+A720-A7FF; } /* latin */ @font-face { font-family: 'Merriweather'; font-style: italic; font-weight: 900; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4l0qyriQwlOrhSvowK_l5-eR7NWPf4jvw.woff2) format('woff2'); unicode-range: U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD; } /* cyrillic-ext */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 300; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4n0qyriQwlOrhSvowK_l521wRZVcf6lvg.woff2) format('woff2'); unicode-range: U+0460-052F, U+1C80-1C8A, U+20B4, U+2DE0-2DFF, U+A640-A69F, U+FE2E-FE2F; } /* cyrillic */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 300; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4n0qyriQwlOrhSvowK_l521wRZXMf6lvg.woff2) format('woff2'); unicode-range: U+0301, U+0400-045F, U+0490-0491, U+04B0-04B1, U+2116; } /* vietnamese */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 300; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4n0qyriQwlOrhSvowK_l521wRZV8f6lvg.woff2) format('woff2'); unicode-range: U+0102-0103, U+0110-0111, U+0128-0129, U+0168-0169, U+01A0-01A1, U+01AF-01B0, U+0300-0301, U+0303-0304, U+0308-0309, U+0323, U+0329, U+1EA0-1EF9, U+20AB; } /* latin-ext */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 300; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4n0qyriQwlOrhSvowK_l521wRZVsf6lvg.woff2) format('woff2'); unicode-range: U+0100-02BA, U+02BD-02C5, U+02C7-02CC, U+02CE-02D7, U+02DD-02FF, U+0304, U+0308, U+0329, U+1D00-1DBF, U+1E00-1E9F, U+1EF2-1EFF, U+2020, U+20A0-20AB, U+20AD-20C0, U+2113, U+2C60-2C7F, U+A720-A7FF; } /* latin */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 300; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4n0qyriQwlOrhSvowK_l521wRZWMf6.woff2) format('woff2'); unicode-range: U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD; } /* cyrillic-ext */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 400; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-440qyriQwlOrhSvowK_l5-cSZMZ-Y.woff2) format('woff2'); unicode-range: U+0460-052F, U+1C80-1C8A, U+20B4, U+2DE0-2DFF, U+A640-A69F, U+FE2E-FE2F; } /* cyrillic */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 400; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-440qyriQwlOrhSvowK_l5-eCZMZ-Y.woff2) format('woff2'); unicode-range: U+0301, U+0400-045F, U+0490-0491, U+04B0-04B1, U+2116; } /* vietnamese */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 400; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-440qyriQwlOrhSvowK_l5-cyZMZ-Y.woff2) format('woff2'); unicode-range: U+0102-0103, U+0110-0111, U+0128-0129, U+0168-0169, U+01A0-01A1, U+01AF-01B0, U+0300-0301, U+0303-0304, U+0308-0309, U+0323, U+0329, U+1EA0-1EF9, U+20AB; } /* latin-ext */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 400; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-440qyriQwlOrhSvowK_l5-ciZMZ-Y.woff2) format('woff2'); unicode-range: U+0100-02BA, U+02BD-02C5, U+02C7-02CC, U+02CE-02D7, U+02DD-02FF, U+0304, U+0308, U+0329, U+1D00-1DBF, U+1E00-1E9F, U+1EF2-1EFF, U+2020, U+20A0-20AB, U+20AD-20C0, U+2113, U+2C60-2C7F, U+A720-A7FF; } /* latin */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 400; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-440qyriQwlOrhSvowK_l5-fCZM.woff2) format('woff2'); unicode-range: U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD; } /* cyrillic-ext */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 700; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4n0qyriQwlOrhSvowK_l52xwNZVcf6lvg.woff2) format('woff2'); unicode-range: U+0460-052F, U+1C80-1C8A, U+20B4, U+2DE0-2DFF, U+A640-A69F, U+FE2E-FE2F; } /* cyrillic */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 700; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4n0qyriQwlOrhSvowK_l52xwNZXMf6lvg.woff2) format('woff2'); unicode-range: U+0301, U+0400-045F, U+0490-0491, U+04B0-04B1, U+2116; } /* vietnamese */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 700; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4n0qyriQwlOrhSvowK_l52xwNZV8f6lvg.woff2) format('woff2'); unicode-range: U+0102-0103, U+0110-0111, U+0128-0129, U+0168-0169, U+01A0-01A1, U+01AF-01B0, U+0300-0301, U+0303-0304, U+0308-0309, U+0323, U+0329, U+1EA0-1EF9, U+20AB; } /* latin-ext */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 700; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4n0qyriQwlOrhSvowK_l52xwNZVsf6lvg.woff2) format('woff2'); unicode-range: U+0100-02BA, U+02BD-02C5, U+02C7-02CC, U+02CE-02D7, U+02DD-02FF, U+0304, U+0308, U+0329, U+1D00-1DBF, U+1E00-1E9F, U+1EF2-1EFF, U+2020, U+20A0-20AB, U+20AD-20C0, U+2113, U+2C60-2C7F, U+A720-A7FF; } /* latin */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 700; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4n0qyriQwlOrhSvowK_l52xwNZWMf6.woff2) format('woff2'); unicode-range: U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD; } /* cyrillic-ext */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 900; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4n0qyriQwlOrhSvowK_l52_wFZVcf6lvg.woff2) format('woff2'); unicode-range: U+0460-052F, U+1C80-1C8A, U+20B4, U+2DE0-2DFF, U+A640-A69F, U+FE2E-FE2F; } /* cyrillic */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 900; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4n0qyriQwlOrhSvowK_l52_wFZXMf6lvg.woff2) format('woff2'); unicode-range: U+0301, U+0400-045F, U+0490-0491, U+04B0-04B1, U+2116; } /* vietnamese */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 900; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4n0qyriQwlOrhSvowK_l52_wFZV8f6lvg.woff2) format('woff2'); unicode-range: U+0102-0103, U+0110-0111, U+0128-0129, U+0168-0169, U+01A0-01A1, U+01AF-01B0, U+0300-0301, U+0303-0304, U+0308-0309, U+0323, U+0329, U+1EA0-1EF9, U+20AB; } /* latin-ext */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 900; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4n0qyriQwlOrhSvowK_l52_wFZVsf6lvg.woff2) format('woff2'); unicode-range: U+0100-02BA, U+02BD-02C5, U+02C7-02CC, U+02CE-02D7, U+02DD-02FF, U+0304, U+0308, U+0329, U+1D00-1DBF, U+1E00-1E9F, U+1EF2-1EFF, U+2020, U+20A0-20AB, U+20AD-20C0, U+2113, U+2C60-2C7F, U+A720-A7FF; } /* latin */ @font-face { font-family: 'Merriweather'; font-style: normal; font-weight: 900; font-display: swap; src: url(https://fonts.gstatic.com/s/merriweather/v30/u-4n0qyriQwlOrhSvowK_l52_wFZWMf6.woff2) format('woff2'); unicode-range: U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD; } :root { --font-base: sans-serif; --font-headings: Merriweather; } body, #content, .entry-content, .post-content, .page-content, .post-excerpt, .entry-summary, .entry-excerpt, .widget-area, .widget, .sidebar, #sidebar, footer, .footer, #footer, .site-footer { font-family: sans-serif; } #site-title, .site-title, #site-title a, .site-title a, .entry-title, .entry-title a, h1, h2, h3, h4, h5, h6, .widget-title, .elementor-heading-title { font-family: "Merriweather"; font-weight: 700; } </style>  </head> <body class="archive tag tag-nucleotide tag-3064946 franklin-child-1-0-11"> <div id="page" class="hfeed site"> <a class="skip-link screen-reader-text" href="#primary">Skip to content</a> <header id="masthead" class="site-header" role="banner"> <div class="site-header-top"> <div class="inner"> <a href="https://www.ncbi.nlm.nih.gov" 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onSelectChange() { if ( dropdown.options[ dropdown.selectedIndex ].value !== '' ) { document.location.href = this.options[ this.selectedIndex ].value; } } dropdown.onchange = onSelectChange; })(); /* ]]> */ </script> </aside><aside id="block-2" class="widget widget_block"><a href="https://www.ncbi.nlm.nih.gov/books/NBK1969/">NCBI News Archive 1994-2017</a></aside> </div> </div> <div id="primary" class="content-area"> <main id="main" class="site-main" role="main"> <p class="archives-label">Tag: <span>NCBI Nucleotide</span></p> <article id="post-14122" class="post-14122 post type-post status-publish format-standard has-post-thumbnail hentry category-whats-new tag-genome-data-viewer tag-mane tag-nucleotide tag-protein"> <div class="post-image-link"><a rel="bookmark" href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/28/mane-v1-4-mane-select-non-coding-genes/"><img width="1108" height="627" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/MANE_Release-1-e1729890803554.png?resize=1100%2C575&ssl=1" class="attachment-post-thumbnail size-post-thumbnail wp-post-image" alt="MANE v1.4 with MANE Select for Non-Coding Genes" decoding="async" fetchpriority="high" data-attachment-id="14126" data-permalink="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/28/mane-v1-4-mane-select-non-coding-genes/mane_release-1/" data-orig-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/MANE_Release-1-e1729890803554.png?fit=1100%2C575&ssl=1" data-orig-size="1100,575" data-comments-opened="1" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="MANE_Release (1)" data-image-description="" data-image-caption="" data-medium-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/MANE_Release-1-e1729890803554.png?fit=300%2C157&ssl=1" data-large-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/10/MANE_Release-1-e1729890803554.png?fit=1024%2C535&ssl=1" /></a></div> <header class="entry-header"> <h1 class="entry-title"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/28/mane-v1-4-mane-select-non-coding-genes/" rel="bookmark">MANE v1.4 with MANE Select for Non-Coding Genes</a></h1> </header> <div class="entry-content"> <p><span data-contrast="auto">The next release (v1.4) of </span><a href="https://www.ncbi.nlm.nih.gov/refseq/MANE/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=mane-1.4-20241028"><span data-contrast="none">Matched Annotation from NCBI and EMBL-EBI (MANE)</span></a><span data-contrast="auto"> is here! MANE is a </span><a href="https://www.nature.com/articles/s41586-022-04558-8"><span data-contrast="none">collaborative dataset</span></a><span data-contrast="auto"> produced jointly by NCBI and EMBL-EBI that provides a representative transcript (MANE Select) for human protein-coding genes, to be used as universal standards for variant reporting and browser display. A second transcript, MANE Plus Clinical, is provided for genes where MANE Select alone is not sufficient to report all known variants. The new MANE release adds another important component to this high-value dataset – non-coding genes, some of which are known to be </span><a href="https://pubmed.ncbi.nlm.nih.gov/37968332/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=mane-1.4-20241028"><span data-contrast="none">associated with human disease.</span></a><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":240}"> </span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":240}"> </span> <a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/28/mane-v1-4-mane-select-non-coding-genes/#more-14122" class="more-link">Continue reading <span class="screen-reader-text">“MANE v1.4 with MANE Select for Non-Coding Genes”</span> <span class="meta-nav">→</span></a></p> </div> <footer class="entry-footer"> <ul class="post-meta"><li class="author vcard"><a class="url fn n" href="https://ncbiinsights.ncbi.nlm.nih.gov/author/ncbiinsights/">NCBI Staff</a></li><li class="posted-on"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/10/28/mane-v1-4-mane-select-non-coding-genes/" rel="bookmark"><time class="entry-date published" datetime="2024-10-28T09:47:17-04:00">October 28, 2024</time><time class="updated" datetime="2024-11-04T14:06:59-05:00">November 4, 2024</time></a></li></ul> <div class="meta-wrapper"> <ul class="post-tags"><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/genome-data-viewer/" rel="tag">Genome Data Viewer (GDV)</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/mane/" rel="tag">Matched Annotation from NCBI and EMBL-EBI (MANE)</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/nucleotide/" rel="tag">NCBI Nucleotide</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/protein/" rel="tag">Protein</a></li></ul> </div> </footer> </article> <article id="post-7085" class="post-7085 post type-post status-publish format-standard hentry category-whats-new tag-accession-version tag-gi tag-nucleotide tag-protein tag-records tag-sequences"> <header class="entry-header"> <h1 class="entry-title"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2021/10/27/64-bit-gis-update/" rel="bookmark">NCBI will assign 64-bit numeric GIs by November 15th. Update affected software!</a></h1> </header> <div class="entry-content"> <p>As <a href="https://ncbiinsights.ncbi.nlm.nih.gov/2021/09/02/64-bit-gis/">announced</a> last month, NCBI will begin assigning larger (64-bit) numeric ‘GIs’ to the remaining sequence types that still receive these identifiers. This change is expected <b>as soon as Nov. 15th, 2021</b> but could occur earlier if data submission volumes are unexpectedly high. This is a reminder that all organizations and developers using our products should review software for any remaining reliance on GIs and compatibility with these larger identifiers.</p> <p><b>How do you know if your software or organization may be impacted?</b></p> <p>If you have built custom software to interface with NCBI data and consume a sequence database UID (i.e. GI), process the GI from an ASN1 or XML product, or process the GI from <em>any</em> tabular product on FTP, you should review all code to ensure that the new, longer, 64-bit GIs will be handled properly. To ensure a smooth transition and the best overall experience, please update to the latest versions of NCBI-provided programmatic and command line tools. Alternatively, you could make updates to your code to use accession.version identifiers instead of GIs.</p> <p>NCBI is here to help the community as we make this change. Stay tuned here or follow <a class="external-link" title="Follow link" href="https://twitter.com/NCBI" target="_blank" rel="nofollow noopener">NCBI Twitter</a> where we will share updates and additional information, such as a final confirmation of the projected cutover date.</p> <p>Please contact <span class="nobr"><a class="external-link" title="Follow link" href="mailto:info@ncbi.nlm.nih.gov?subject=NCBI%20Insights%2064%20GI%20Update" target="_blank" rel="nofollow noopener">info@ncbi.nlm.nih.gov<sup><img data-recalc-dims="1" decoding="async" class="rendericon" src="https://i0.wp.com/jira.ncbi.nlm.nih.gov/images/icons/mail_small.gif?resize=13%2C12&ssl=1" alt="" width="13" height="12" align="absmiddle" border="0" /></sup></a></span> with any questions about this change or to determine if any software you are using is affected.</p> </div> <footer class="entry-footer"> <ul class="post-meta"><li class="author vcard"><a class="url fn n" href="https://ncbiinsights.ncbi.nlm.nih.gov/author/ncbiinsights/">NCBI Staff</a></li><li class="posted-on"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2021/10/27/64-bit-gis-update/" rel="bookmark"><time class="entry-date published" datetime="2021-10-27T12:06:47-04:00">October 27, 2021</time><time class="updated" datetime="2021-10-27T12:09:30-04:00">October 27, 2021</time></a></li></ul> <div class="meta-wrapper"> <ul class="post-tags"><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/accession-version/" rel="tag">Accession.version</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/gi/" rel="tag">GenInfo Identifier (GI)</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/nucleotide/" rel="tag">NCBI Nucleotide</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/protein/" rel="tag">Protein</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/records/" rel="tag">Records</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/sequences/" rel="tag">Sequences</a></li></ul> </div> </footer> </article> <article id="post-5687" class="post-5687 post type-post status-publish format-standard has-post-thumbnail hentry category-whats-new tag-assembly tag-datasets tag-eukaryotic-genome-annotation tag-gdh tag-genome-data-viewer tag-nucleotide tag-protein"> <div class="post-image-link"><a rel="bookmark" href="https://ncbiinsights.ncbi.nlm.nih.gov/2021/05/17/vgp-ncbi/"><img width="1108" height="635" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2021/05/VGP_Platypus_no_border.png?resize=1108%2C635&ssl=1" class="attachment-post-thumbnail size-post-thumbnail wp-post-image" alt="Vertebrate Genome Project genome assemblies annotated by NCBI" decoding="async" data-attachment-id="5702" data-permalink="https://ncbiinsights.ncbi.nlm.nih.gov/2021/05/17/vgp-ncbi/vgp_platypus_no_border/" data-orig-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2021/05/VGP_Platypus_no_border.png?fit=1133%2C635&ssl=1" data-orig-size="1133,635" data-comments-opened="1" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="VGP_Platypus_no_border" data-image-description="" data-image-caption="" data-medium-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2021/05/VGP_Platypus_no_border.png?fit=300%2C168&ssl=1" data-large-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2021/05/VGP_Platypus_no_border.png?fit=1024%2C574&ssl=1" /></a></div> <header class="entry-header"> <h1 class="entry-title"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2021/05/17/vgp-ncbi/" rel="bookmark">Vertebrate Genome Project genome assemblies annotated by NCBI</a></h1> </header> <div class="entry-content"> <p>NCBI is an active partner of the <a href="https://www.ncbi.nlm.nih.gov/assembly?LinkName=bioproject_assembly_all&from_uid=489243&utm_source=blog&utm_medium=referrer&utm_campaign=refseq-annotation&utm_term=vgp-annot&utm_content=20210517link1">Vertebrate Genomes Project (VGP)</a>, who recently published a <a href="https://www.nature.com/articles/d42859-021-00001-6">series of papers</a> on the initial results of their efforts to sequence all 70,000 vertebrate species. See the VGP <a href="https://www.eurekalert.org/pub_releases/2021-04/ru-tvg042621.php">press release</a> for more details. To date, this project has submitted over <a href="https://www.ncbi.nlm.nih.gov/assembly?LinkName=bioproject_assembly_all&from_uid=489243">130 diploid chromosome-level assemblies</a> to <a href="https://www.ncbi.nlm.nih.gov/genbank/?utm_source=blog&utm_medium=referrer&utm_campaign=refseq-annotation&utm_term=vgp-annot&utm_content=20210517link2">NCBI’s GenBank</a> and the <a href="https://www.ebi.ac.uk/ena/browser/home">European Nucleotide Archive</a>. NCBI has annotated 94 of the VGP assemblies from 85 species using the <a href="https://www.ncbi.nlm.nih.gov/genome/annotation_euk/?utm_source=blog&utm_medium=referrer&utm_campaign=refseq-annotation&utm_term=vgp-annot&utm_content=20210517link3">NCBI Eukaryotic Genome Annotation Pipeline</a>.</p> <p>These sequence and annotation data are <a href="https://www.ncbi.nlm.nih.gov/assembly?LinkName=bioproject_assembly_all&from_uid=489243&utm_source=blog&utm_medium=referrer&utm_campaign=refseq-annotation&utm_term=vgp-annot&utm_content=20210517link4">available</a> through NCBI web resources including <a href="https://www.ncbi.nlm.nih.gov/gene/?utm_source=blog&utm_medium=referrer&utm_campaign=refseq-annotation&utm_term=vgp-annot&utm_content=20210517link5">Gene</a>, <a href="https://www.ncbi.nlm.nih.gov/assembly/?utm_source=blog&utm_medium=referrer&utm_campaign=refseq-annotation&utm_term=vgp-annot&utm_content=20210517link6">Assembly</a>, <a href="https://www.ncbi.nlm.nih.gov/nuccore/?utm_source=blog&utm_medium=referrer&utm_campaign=refseq-annotation&utm_term=vgp-annot&utm_content=20210517link7">Nucleotide</a>, <a href="https://www.ncbi.nlm.nih.gov/protein/?utm_source=blog&utm_medium=referrer&utm_campaign=refseq-annotation&utm_term=vgp-annot&utm_content=20210517link8">Protein</a>, and <a href="https://www.ncbi.nlm.nih.gov/datasets/?utm_source=blog&utm_medium=referrer&utm_campaign=refseq-annotation&utm_term=vgp-annot&utm_content=20210517link9">Datasets</a> and are included in the <a href="https://ftp.ncbi.nlm.nih.gov/genbank/">GenBank</a> and <a href="https://ftp.ncbi.nlm.nih.gov/refseq/">RefSeq</a> releases. You can browse the assemblies in the <a href="https://www.ncbi.nlm.nih.gov/genome/gdv?utm_source=blog&utm_medium=referrer&utm_campaign=refseq-annotation&utm_term=vgp-annot&utm_content=20210517link10">Genome Data Viewer</a> and <span style="font-size: 1.125rem;"> download metadata, sequence, and annotation data for the latest assemblies in the <a href="https://www.ncbi.nlm.nih.gov/datasets/docs/quickstarts/command-line-tools/?utm_source=blog&utm_medium=referrer&utm_campaign=refseq-annotation&utm_term=vgp-annot&utm_content=20210517link12">VGP BioProject</a> using the <a href="https://www.ncbi.nlm.nih.gov/datasets/docs/quickstarts/command-line-tools/?utm_source=blog&utm_medium=referrer&utm_campaign=refseq-annotation&utm_term=vgp-annot&utm_content=20210517link11">NCBI Datasets command-line tools</a></span> as shown below. <a href="https://ncbiinsights.ncbi.nlm.nih.gov/2021/05/17/vgp-ncbi/#more-5687" class="more-link">Continue reading <span class="screen-reader-text">“Vertebrate Genome Project genome assemblies annotated by NCBI”</span> <span class="meta-nav">→</span></a></p> </div> <footer class="entry-footer"> <ul class="post-meta"><li class="author vcard"><a class="url fn n" href="https://ncbiinsights.ncbi.nlm.nih.gov/author/ncbiinsights/">NCBI Staff</a></li><li class="posted-on"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2021/05/17/vgp-ncbi/" rel="bookmark"><time class="entry-date published" datetime="2021-05-17T13:25:51-04:00">May 17, 2021</time><time class="updated" datetime="2021-05-17T14:22:42-04:00">May 17, 2021</time></a></li></ul> <div class="meta-wrapper"> <ul class="post-tags"><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/assembly/" rel="tag">Assembly</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/datasets/" rel="tag">Datasets</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/eukaryotic-genome-annotation/" rel="tag">Eukaryotic genome annotation</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/gdh/" rel="tag">GDH</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/genome-data-viewer/" rel="tag">Genome Data Viewer (GDV)</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/nucleotide/" rel="tag">NCBI Nucleotide</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/protein/" rel="tag">Protein</a></li></ul> </div> </footer> </article> <article id="post-5163" class="post-5163 post type-post status-publish format-standard hentry category-whats-new tag-assembly tag-nucleotide tag-prokaryotic-genome-annotation tag-protein tag-representative-genome"> <header class="entry-header"> <h1 class="entry-title"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2021/01/12/updated_prok-rep-assemblies/" rel="bookmark">Prokaryotic representative genomes updated — now over 13 thousand assemblies!</a></h1> </header> <div class="entry-content"> <p>We have updated the bacterial and archaeal <a href="https://www.ncbi.nlm.nih.gov/assembly/?term=(Bacteria%5Borgn%5D%20OR%20Archaea%5Borgn%5D)%20AND%20(reference_genome%5Bfilter%5D%20OR%20representative_genome%5Bfilter%5D)&utm_source=blog&utm_medium=referrer&utm_campaign=repr_genomes&utm_term=release&utm_content=20210112link1">representative genome collection</a>! The current collection contains over 13,000 assemblies selected from the 203,000 prokaryotic RefSeq assemblies to <a href="https://www.ncbi.nlm.nih.gov/refseq/about/prokaryotes/?utm_source=blog&utm_medium=referrer&utm_campaign=repr_genomes&utm_term=release&utm_content=20210112link2#representative_genomes">represent</a> their respective species. The collection has increased by 11% since August 2020. We’ve included about 1,400 species for the first time, have used better assemblies for 1,177 species, and have removed 65 species because of changes in NCBI Taxonomy or uncertainty in their species assignment.</p> <p>We have also updated the Representative Genomes Database on the <a href="https://blast.ncbi.nlm.nih.gov/Blast.cgi?PAGE_TYPE=BlastSearch&BLAST_SPEC=MicrobialGenomes&DATABASE=ref_prok_rep_genomes&utm_source=blog&utm_medium=referrer&utm_campaign=repr_genomes&utm_term=release&utm_content=20210112link3">Microbial Nucleotide BLAST page</a> as well as the RefSeq Representative Genome Database on <a href="https://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastn&PAGE_TYPE=BlastSearch&DATABASE=refseq_representative_genomes&utm_source=blog&utm_medium=referrer&utm_campaign=repr_genomes&utm_term=release&utm_content=20210112link4">basic nucleotide BLAST</a>, to reflect these changes. <a href="https://ncbiinsights.ncbi.nlm.nih.gov/2021/01/12/updated_prok-rep-assemblies/#more-5163" class="more-link">Continue reading <span class="screen-reader-text">“Prokaryotic representative genomes updated — now over 13 thousand assemblies!”</span> <span class="meta-nav">→</span></a></p> </div> <footer class="entry-footer"> <ul class="post-meta"><li class="author vcard"><a class="url fn n" href="https://ncbiinsights.ncbi.nlm.nih.gov/author/ncbiinsights/">NCBI Staff</a></li><li class="posted-on"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2021/01/12/updated_prok-rep-assemblies/" rel="bookmark"><time class="entry-date published" datetime="2021-01-12T17:31:18-05:00">January 12, 2021</time><time class="updated" datetime="2021-01-12T17:51:26-05:00">January 12, 2021</time></a></li></ul> <div class="meta-wrapper"> <ul class="post-tags"><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/assembly/" rel="tag">Assembly</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/nucleotide/" rel="tag">NCBI Nucleotide</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/prokaryotic-genome-annotation/" rel="tag">Prokaryotic genome annotation</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/protein/" rel="tag">Protein</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/representative-genome/" rel="tag">Representative genome</a></li></ul> </div> </footer> </article> <article id="post-3440" class="post-3440 post type-post status-publish format-standard hentry category-whats-new tag-coronavirus tag-covid-19 tag-genbank tag-genome tag-nucleotide tag-sars-cov-2 tag-sequences tag-viruses"> <header class="entry-header"> <h1 class="entry-title"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2020/01/13/novel-coronavirus/" rel="bookmark">Novel coronavirus complete genome from the Wuhan outbreak now available in GenBank</a></h1> </header> <div class="entry-content"> <p><strong><em>Updated!</em></strong></p> <p style="padding-left: 40px;"><strong><em>Get rapid access to Wuhan coronavirus (2019-nCoV) <a href="https://www.ncbi.nlm.nih.gov/genbank/2019-ncov-seqs/?utm_campaign=wuhan_nCoV&utm_source=insights&utm_medium=referral">sequence data</a> from the current outbreak as it becomes available. We will continue to update the page with newly released data.</em></strong></p> <p>The complete annotated genome sequence of the novel coronavirus associated with the <a href="https://www.who.int/westernpacific/emergencies/pneumonia-in-wuhan-china">outbreak of pneumonia</a> in Wuhan, China is now <a href="https://www.ncbi.nlm.nih.gov/nuccore/MN908947">available</a> from GenBank for free and easy access by the global biomedical community. Figure 1 shows the relationship of the Wuhan virus to selected coronaviruses.</p> <p><img data-recalc-dims="1" loading="lazy" decoding="async" data-attachment-id="3444" data-permalink="https://ncbiinsights.ncbi.nlm.nih.gov/2020/01/13/novel-coronavirus/wuhan-human-1_posterior-output2/" data-orig-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2020/01/wuhan-human-1_posterior-output2.png?fit=1000%2C600&ssl=1" data-orig-size="1000,600" data-comments-opened="1" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="Wuhan-human-1_posterior-output2" data-image-description="" data-image-caption="" data-medium-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2020/01/wuhan-human-1_posterior-output2.png?fit=300%2C180&ssl=1" data-large-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2020/01/wuhan-human-1_posterior-output2.png?fit=1000%2C600&ssl=1" class="alignnone size-full wp-image-3444" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2020/01/wuhan-human-1_posterior-output2.png?resize=1000%2C600&ssl=1" alt="Wuhan-human-1_posterior-output2" width="1000" height="600" /></p> <p><em>Figure 1. Phylogenetic tree showing the relationship of Wuhan-Hu-1 (circled in red) to selected coronaviruses. Nucleotide alignment was done with <a href="https://www.drive5.com/muscle/">MUSCLE</a> 3.8. The phylogenetic tree was estimated with <a href="https://nbisweden.github.io/MrBayes/download.html">MrBayes</a> 3.2.6 with parameters for GTR+g+i. The scale bar indicates estimated substitutions per site, and all branch support values are 99.3% or higher.</em></p> <p> <a href="https://ncbiinsights.ncbi.nlm.nih.gov/2020/01/13/novel-coronavirus/#more-3440" class="more-link">Continue reading <span class="screen-reader-text">“Novel coronavirus complete genome from the Wuhan outbreak now available in GenBank”</span> <span class="meta-nav">→</span></a></p> </div> <footer class="entry-footer"> <ul class="post-meta"><li class="author vcard"><a class="url fn n" href="https://ncbiinsights.ncbi.nlm.nih.gov/author/ncbiinsights/">NCBI Staff</a></li><li class="posted-on"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2020/01/13/novel-coronavirus/" rel="bookmark"><time class="entry-date published" datetime="2020-01-13T16:51:26-05:00">January 13, 2020</time><time class="updated" datetime="2020-04-06T10:51:57-04:00">April 6, 2020</time></a></li></ul> <div class="meta-wrapper"> <ul class="post-tags"><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/coronavirus/" rel="tag">Coronavirus</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/covid-19/" rel="tag">COVID-19</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/genbank/" rel="tag">GenBank</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/genome/" rel="tag">Genome</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/nucleotide/" rel="tag">NCBI Nucleotide</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/sars-cov-2/" rel="tag">SARS-CoV-2</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/sequences/" rel="tag">Sequences</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/viruses/" rel="tag">Viruses</a></li></ul> </div> </footer> </article> <article id="post-3246" class="post-3246 post type-post status-publish format-standard hentry category-whats-new tag-nucleotide"> <header class="entry-header"> <h1 class="entry-title"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2019/11/19/ncbi-will-retire-the-probe-database-in-april-2020/" rel="bookmark">NCBI Will Retire the Probe Database in April 2020</a></h1> </header> <div class="entry-content"> <p>NCBI released the <a href="https://www.ncbi.nlm.nih.gov/probe/" target="_blank" rel="noopener">Probe database</a> in 2005 as a registry of nucleic acid reagents for biomedical research. At that time array-based assays were prevalent, but have since declined with the advent of short read sequencing. As a result, NCBI will retire the web interface for the Probe database in April 2020. You can continue accessing the content of the database on the <a href="ftp://ftp.ncbi.nlm.nih.gov/pub/ProbeDB/" target="_blank" rel="noopener">NCBI FTP site</a>, but it will no longer be updated. As of this announcement, Probe will no longer be accepting new submissions.</p> <p>If you have questions or concerns about this retirement, we’d love to hear from you. Please comment here or contact us at <a href="mailto:info@ncbi.nlm.nih.gov">info@ncbi.nlm.nih.gov</a>.</p> </div> <footer class="entry-footer"> <ul class="post-meta"><li class="author vcard"><a class="url fn n" href="https://ncbiinsights.ncbi.nlm.nih.gov/author/ncbiinsights/">NCBI Staff</a></li><li class="posted-on"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2019/11/19/ncbi-will-retire-the-probe-database-in-april-2020/" rel="bookmark"><time class="entry-date published updated" datetime="2019-11-19T13:50:53-05:00">November 19, 2019</time></a></li></ul> <div class="meta-wrapper"> <ul class="post-tags"><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/nucleotide/" rel="tag">NCBI Nucleotide</a></li></ul> </div> </footer> </article> <article id="post-3157" class="post-3157 post type-post status-publish format-standard hentry category-whats-new tag-genome-browser tag-nucleotide tag-sequence-viewer tag-sequences"> <header class="entry-header"> <h1 class="entry-title"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2019/10/15/vector-graphics-downloads-now-available-in-ncbi-genome-browsers-and-sequence-views/" rel="bookmark">Vector graphics downloads now available in NCBI genome browsers and sequence views</a></h1> </header> <div class="entry-content"> <p>You can now download images in both PDF and Scaled Vector Graphics (SVG) formats from our Sequence Viewer and genome browsers such as the Genome Data Viewer! SVG files are ideal for editing in image editors and provide high quality graphics for publications, posters, and presentations. Both the PDF and SVG files that you download contain vector graphics for high fidelity images.</p> <p>You can download image files by choosing the “Printer-Friendly PDF/SVG” option under the Tools menu from any Graphical Sequence Viewer application (Figure 1).</p> <p><img data-recalc-dims="1" loading="lazy" decoding="async" data-attachment-id="3176" data-permalink="https://ncbiinsights.ncbi.nlm.nih.gov/2019/10/15/vector-graphics-downloads-now-available-in-ncbi-genome-browsers-and-sequence-views/svg_gdv/" data-orig-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2019/10/svg_gdv.png?fit=2480%2C1544&ssl=1" data-orig-size="2480,1544" data-comments-opened="1" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="SVG_GDV" data-image-description="" data-image-caption="" data-medium-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2019/10/svg_gdv.png?fit=300%2C187&ssl=1" data-large-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2019/10/svg_gdv.png?fit=1024%2C638&ssl=1" class="alignnone size-full wp-image-3176" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2019/10/svg_gdv.png?resize=1108%2C690&ssl=1" alt="SVG_GDV" width="1108" height="690" /><em>Figure 1. Printer friendly download options from the graphical view in the Genome Data Viewer. You can download either PDF or SVG formats, which are easily edited in standard graphics applications. </em></p> <p> </p> </div> <footer class="entry-footer"> <ul class="post-meta"><li class="author vcard"><a class="url fn n" href="https://ncbiinsights.ncbi.nlm.nih.gov/author/ncbiinsights/">NCBI Staff</a></li><li class="posted-on"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2019/10/15/vector-graphics-downloads-now-available-in-ncbi-genome-browsers-and-sequence-views/" rel="bookmark"><time class="entry-date published updated" datetime="2019-10-15T16:03:59-04:00">October 15, 2019</time></a></li></ul> <div class="meta-wrapper"> <ul class="post-tags"><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/genome-browser/" rel="tag">Genome Browser</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/nucleotide/" rel="tag">NCBI Nucleotide</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/sequence-viewer/" rel="tag">Sequence Viewer</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/sequences/" rel="tag">Sequences</a></li></ul> </div> </footer> </article> <article id="post-3056" class="post-3056 post type-post status-publish format-standard hentry category-whats-new tag-chloroplasts tag-mitochondria tag-nucleotide tag-protein tag-sequences"> <header class="entry-header"> <h1 class="entry-title"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2019/09/23/new-results-for-organelle-genome-searches/" rel="bookmark">New results for organelle genome searches</a></h1> </header> <div class="entry-content"> <p>As part of our ongoing effort to improve your search experience, we’ve made it easier for you to find the sequence of your favorite organelle genome plus all the information and data associated with it. To find organelle genomes, search for an organism name combined with an organelle description, for example <a class="external-link" href="https://www.ncbi.nlm.nih.gov/search/all/?term=human+mitochondrion" rel="nofollow">human mitochondrion</a>, <a class="external-link" href="https://www.ncbi.nlm.nih.gov/search/all/?term=tomato+chloroplast" rel="nofollow">tomato chloroplast</a> or <a class="external-link" href="https://www.ncbi.nlm.nih.gov/search/all/?term=Toxoplasma+gondii+RH+apicoplast" rel="nofollow">Toxoplasma gondii RH apicoplast</a>.</p> <p>A new results panel will appear with links to the organelle genome sequence, annotated genes, and related phylogenetic and population studies. The panel appears with these searches in an All Databases search or within any of NCBI’s sequence databases including Gene, Nucleotide, Protein, Genome, Assembly. For the human mitochondrial genome, a graphical schematic of the genome allows you to navigate to individual mitochondrial encoded genes (Figure 1).</p> <p><img data-recalc-dims="1" loading="lazy" decoding="async" data-attachment-id="3059" data-permalink="https://ncbiinsights.ncbi.nlm.nih.gov/2019/09/23/new-results-for-organelle-genome-searches/organelle_sensor/" data-orig-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2019/09/organelle_sensor.png?fit=1802%2C1636&ssl=1" data-orig-size="1802,1636" data-comments-opened="1" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="Organelle_sensor" data-image-description="" data-image-caption="" data-medium-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2019/09/organelle_sensor.png?fit=300%2C272&ssl=1" data-large-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2019/09/organelle_sensor.png?fit=1024%2C930&ssl=1" class="alignnone size-full wp-image-3059" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2019/09/organelle_sensor.png?resize=1108%2C1006&ssl=1" alt="Organelle_sensor" width="1108" height="1006" /></p> <p><em>Figure 1. The organelle genome results for a search with human mitochondrion. The panel provides access to analysis tools, downloads, and other relevant results. Clicking any of the gene objects on the genome graphic links leads to the relevant Gene record, for example Gene ID: <a href="https://www.ncbi.nlm.nih.gov/gene/4512">4512</a> in the case of COX1.</em></p> <p>Try it out using the following example searches and <a href="mailto:suggest@ncbi.nlm.nih.gov?subject=Virus%20Graphic%20Feedback">let us know</a> what you think!</p> <ul> <li><a href="https://www.ncbi.nlm.nih.gov/gene/?term=Thale+cress+chloroplast">Thale cress chloroplast</a></li> <li><a href="https://www.ncbi.nlm.nih.gov/gene/?term=Thale+cress+chloroplast">mouse mitochondrion</a></li> <li><a href="https://www.ncbi.nlm.nih.gov/nuccore/?term=Leishmania+tarentolae+kinetoplast">Leishmania tarentolae kinetoplast</a></li> </ul> </div> <footer class="entry-footer"> <ul class="post-meta"><li class="author vcard"><a class="url fn n" href="https://ncbiinsights.ncbi.nlm.nih.gov/author/ncbiinsights/">NCBI Staff</a></li><li class="posted-on"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2019/09/23/new-results-for-organelle-genome-searches/" rel="bookmark"><time class="entry-date published updated" datetime="2019-09-23T15:29:35-04:00">September 23, 2019</time></a></li></ul> <div class="meta-wrapper"> <ul class="post-tags"><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/chloroplasts/" rel="tag">Chloroplasts</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/mitochondria/" rel="tag">Mitochondria</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/nucleotide/" rel="tag">NCBI Nucleotide</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/protein/" rel="tag">Protein</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/sequences/" rel="tag">Sequences</a></li></ul> </div> </footer> </article> <article id="post-3003" class="post-3003 post type-post status-publish format-standard has-post-thumbnail hentry category-whats-new tag-gene tag-nucleotide tag-protein tag-sequences"> <div class="post-image-link"><a rel="bookmark" href="https://ncbiinsights.ncbi.nlm.nih.gov/2019/09/04/september-11-webinar-a-beginners-guide-to-genes-and-sequences-at-ncbi/"><img width="1108" height="628" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2019/07/webinars_3.png?resize=1108%2C628&ssl=1" class="attachment-post-thumbnail size-post-thumbnail wp-post-image" alt="September 11 Webinar: A beginner’s guide to genes and sequences at NCBI" decoding="async" loading="lazy" data-attachment-id="2967" data-permalink="https://ncbiinsights.ncbi.nlm.nih.gov/2019/07/31/august-14-webinar-an-updated-pubmed-is-on-its-way/webinars_3/" data-orig-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2019/07/webinars_3.png?fit=1200%2C628&ssl=1" data-orig-size="1200,628" data-comments-opened="1" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="webinars_3" data-image-description="" data-image-caption="" data-medium-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2019/07/webinars_3.png?fit=300%2C157&ssl=1" data-large-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2019/07/webinars_3.png?fit=1024%2C536&ssl=1" /></a></div> <header class="entry-header"> <h1 class="entry-title"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2019/09/04/september-11-webinar-a-beginners-guide-to-genes-and-sequences-at-ncbi/" rel="bookmark">September 11 Webinar: A beginner’s guide to genes and sequences at NCBI</a></h1> </header> <div class="entry-content"> <p>On Wednesday, September 11, 2019 at 12 PM, NCBI staff will present a webinar for people with limited experience working with gene and sequence information. You will learn about the kinds of data available for genes and sequences, how to select the most informative records, and how to find related genes and sequences using pre-computed information and the BLAST sequence search service.</p> <ul> <li style="text-align:left;"><strong>Date and time:</strong> Wed, Sep 11, 2019 12:00 PM – 12:30 PM EDT</li> <li style="text-align:left;"><strong><a href="https://attendee.gotowebinar.com/register/5143637841818522636?source=NewsSite">Register</a></strong></li> </ul> <p>After registering, you will receive a confirmation email with information about attending the webinar. A few days after the live presentation, you can view the recording on the NCBI YouTube channel. You can learn about future webinars on the Webinars and Courses page.</p> </div> <footer class="entry-footer"> <ul class="post-meta"><li class="author vcard"><a class="url fn n" href="https://ncbiinsights.ncbi.nlm.nih.gov/author/ncbiinsights/">NCBI Staff</a></li><li class="posted-on"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2019/09/04/september-11-webinar-a-beginners-guide-to-genes-and-sequences-at-ncbi/" rel="bookmark"><time class="entry-date published updated" datetime="2019-09-04T16:38:13-04:00">September 4, 2019</time></a></li></ul> <div class="meta-wrapper"> <ul class="post-tags"><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/gene/" rel="tag">Gene</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/nucleotide/" rel="tag">NCBI Nucleotide</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/protein/" rel="tag">Protein</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/sequences/" rel="tag">Sequences</a></li></ul> </div> </footer> </article> <article id="post-2890" class="post-2890 post type-post status-publish format-standard hentry category-whats-new tag-nucleotide tag-primer-blast tag-sequences"> <header class="entry-header"> <h1 class="entry-title"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2019/07/19/primer-blast-now-offers-help-with-irrelevant-off-target-matches/" rel="bookmark">Primer-BLAST now offers help with irrelevant off-target matches</a></h1> </header> <div class="entry-content"> <p><a href="https://www.ncbi.nlm.nih.gov/tools/primer-blast/">Primer-BLAST</a>, NCBI’s primer-designer and specificity-checker, now offers a way to help you with irrelevant off-target matches.</p> <p>Sometimes Primer-BLAST can’t design specific primers for your target sequence because of similar non-target sequences in the database. In some cases, you may know that these non-target matches are not important your research and are safe to ignore. Examples may include tissue-specific splice variants, redundant entries, and predicted sequences. To help in these cases, you can now choose to allow certain off-target matches. This gives Primer-BLAST greater freedom in primer selection and a better chance of finding highly specific primers.</p> <p> <a href="https://ncbiinsights.ncbi.nlm.nih.gov/2019/07/19/primer-blast-now-offers-help-with-irrelevant-off-target-matches/#more-2890" class="more-link">Continue reading <span class="screen-reader-text">“Primer-BLAST now offers help with irrelevant off-target matches”</span> <span class="meta-nav">→</span></a></p> </div> <footer class="entry-footer"> <ul class="post-meta"><li class="author vcard"><a class="url fn n" href="https://ncbiinsights.ncbi.nlm.nih.gov/author/ncbiinsights/">NCBI Staff</a></li><li class="posted-on"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2019/07/19/primer-blast-now-offers-help-with-irrelevant-off-target-matches/" rel="bookmark"><time class="entry-date published" datetime="2019-07-19T12:04:26-04:00">July 19, 2019</time><time class="updated" datetime="2019-07-22T12:16:11-04:00">July 22, 2019</time></a></li></ul> <div class="meta-wrapper"> <ul class="post-tags"><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/nucleotide/" rel="tag">NCBI Nucleotide</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/primer-blast/" rel="tag">Primer-BLAST</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/sequences/" rel="tag">Sequences</a></li></ul> </div> </footer> </article> <nav class="navigation posts-navigation" aria-label="Posts"> <h2 class="screen-reader-text">Posts navigation</h2> <div class="nav-links"><div class="nav-previous"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/nucleotide/page/2/" >Older posts</a></div></div> </nav> </main> </div> </div> <footer> <section class="icon-section"> <div id="icon-section-header" class="icon-section_header" tabindex="0">Contact NCBI on</div> <div class="grid-container"> <div class="icon-section_container"> <a class="footer-icon" id="footer_twitter" href="https://twitter.com/ncbi" aria-label="Twitter"><svg 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