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aria-live="polite">Scholarly Works (3 results)</h2></header><div class="c-sortpagination"><div class="c-sort"><div class="o-input__droplist1"><label for="c-sort1">Sort By:</label><select name="sort" id="c-sort1" form="facetForm"><option selected="" value="rel">Relevance</option><option value="a-title">A-Z By Title</option><option value="z-title">Z-A By Title</option><option value="a-author">A-Z By Author</option><option value="z-author">Z-A By Author</option><option value="asc">Date Ascending</option><option value="desc">Date Descending</option></select></div></div><input type="hidden" name="start" form="facetForm" value="0"/></div><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/7t67t7dr"><div class="c-clientmarkup">Spotlight on afatinib and its potential in the treatment of squamous cell lung cancer: the evidence so far</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AXu%2C%20Yijun">Xu, Yijun</a>; </li><li><a href="/search/?q=author%3ADing%2C%20Vivianne%20W">Ding, Vivianne W</a>; </li><li><a href="/search/?q=author%3AZhang%2C%20Hong">Zhang, Hong</a>; </li><li><a href="/search/?q=author%3AZhang%2C%20Xun">Zhang, Xun</a>; </li><li><a href="/search/?q=author%3AJablons%2C%20David">Jablons, David</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AHe%2C%20Biao">He, Biao</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucsf_postprints">UC San Francisco Previously Published Works</a> (2016)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">Compared to adenocarcinoma, fewer effective treatment options are available for advanced or metastatic squamous cell carcinoma (SCC) of the lung. Afatinib is an orally administered, irreversible EGFR antagonist. As a second-generation tyrosine kinase inhibitor, it has been applied in the treatment of patients with EGFR-mutant non-small-cell lung cancer. Recently, several clinical trials have shown that afatinib leads to a significant improvement in progression-free survival and overall survival of patients with SCC. Moving forward, afatinib should be one of the options among tyrosine kinase inhibitors, monoclonal antibodies, and cytotoxicity chemotherapy drugs for SCC.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/7t67t7dr"><img src="/cms-assets/680a12bb21b045261f9b01f171950a01469fc6de0872095b5f9d5ccc414ee87f" alt="Cover page: Spotlight on afatinib and its potential in the treatment of squamous cell lung cancer: the evidence so far"/></a><a href="https://creativecommons.org/licenses/by-nc/4.0/" class="c-scholworks__license"><img class="c-lazyimage" data-src="/images/cc-by-nc-small.svg" alt="Creative Commons 'BY-NC' version 4.0 license"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/8p6236pt"><div class="c-clientmarkup">Soluble epoxide hydrolase inhibitor can protect the femoral head against tobacco smoke exposure-induced osteonecrosis in spontaneously hypertensive rats</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AXu%2C%20Jingyi">Xu, Jingyi</a>; </li><li><a href="/search/?q=author%3AQiu%2C%20Xing">Qiu, Xing</a>; </li><li><a href="/search/?q=author%3AYu%2C%20Gary">Yu, Gary</a>; </li><li><a href="/search/?q=author%3ALy%2C%20Maria">Ly, Maria</a>; </li><li><a href="/search/?q=author%3AYang%2C%20Jun">Yang, Jun</a>; </li><li><a href="/search/?q=author%3ASilva%2C%20Rona%20M">Silva, Rona M</a>; </li><li><a href="/search/?q=author%3AZhang%2C%20Xun">Zhang, Xun</a>; </li><li><a href="/search/?q=author%3AYu%2C%20Mang">Yu, Mang</a>; </li><li><a href="/search/?q=author%3AWang%2C%20Yinong">Wang, Yinong</a>; </li><li><a href="/search/?q=author%3AHammock%2C%20Bruce">Hammock, Bruce</a>; </li><li><a href="/search/?q=author%3APinkerton%2C%20Kent%20E">Pinkerton, Kent E</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AZhao%2C%20Dewei">Zhao, Dewei</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucd_postprints">UC Davis Previously Published Works</a> (2022)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">Exposure to tobacco smoke (TS) has been considered a risk factor for osteonecrosis of the femoral head (ONFH). Soluble epoxide hydrolase inhibitors (sEHIs) have been found to reduce inflammation and oxidative stress in a variety of pathologies. This study was designed to assess the effect of sEHI on the development of ONFH phenotypes induced by TS exposure in spontaneously hypertensive (SH) rats. SH and normotensive Wistar Kyoto (WKY) rats were exposed to filtered air (FA) or TS (80 mg/m3 particulate concentration) 6 h/day, 3 days/week for 8 weeks. During this period, sEHI was delivered through drinking water at a concentration of 6 mg/L. Histology, immunohistochemistry, and micro-CT morphometry were performed for phenotypic evaluation. As results, TS exposure induced significant increases in adipocyte area, bone specific surface (BS/BV), and trabecular separation (Tb.SP), as well as significant decreases in bone mineral density (BMD), percent trabecular area (Tb.Ar), HIF-1a expression, bone volume fraction (BV/TV), trabecular numbers (Tb.N), and trabecular thickness (Tb.Th) in both SH and WKY rats. However, the protective effects of sEHI were mainly observed in TS-exposed SH rats, specifically in the density of osteocytes, BMD, Tb.Ar, HIF-1a expression, BV/TV, BS/BV, Tb.N, and Tb.SP. Our study confirms that TS exposure can induce ONFH especially in SH rats, and suggests that sEHI therapy may protect against TS exposure-induced osteonecrotic changes in the femoral head.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/8p6236pt"><img src="/cms-assets/3da6f991a97d9e14d7e4b6c3ed04b09348c9f7abd03b32ba01133f036d849300" alt="Cover page: Soluble epoxide hydrolase inhibitor can protect the femoral head against tobacco smoke exposure-induced osteonecrosis in spontaneously hypertensive rats"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/0hv6s32x"><div class="c-clientmarkup">The Society for Translational Medicine: clinical practice guidelines for the postoperative management of chest tube for patients undergoing lobectomy.</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AGao%2C%20Shugeng">Gao, Shugeng</a>; </li><li><a href="/search/?q=author%3AZhang%2C%20Zhongheng">Zhang, Zhongheng</a>; </li><li><a href="/search/?q=author%3AArag%C3%B3n%2C%20Javier">Arag贸n, Javier</a>; </li><li><a href="/search/?q=author%3ABrunelli%2C%20Alessandro">Brunelli, Alessandro</a>; </li><li><a href="/search/?q=author%3ACassivi%2C%20Stephen">Cassivi, Stephen</a>; </li><li><a href="/search/?q=author%3AChai%2C%20Ying">Chai, Ying</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Chang">Chen, Chang</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Chun">Chen, Chun</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Gang">Chen, Gang</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Haiquan">Chen, Haiquan</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Jin-Shing">Chen, Jin-Shing</a>; </li><li><a href="/search/?q=author%3ACooke%2C%20David">Cooke, David</a>; </li><li><a href="/search/?q=author%3ADowns%2C%20John">Downs, John</a>; </li><li><a href="/search/?q=author%3AFalcoz%2C%20Pierre-Emmanuel">Falcoz, Pierre-Emmanuel</a>; </li><li><a href="/search/?q=author%3AFang%2C%20Wentao">Fang, Wentao</a>; </li><li><a href="/search/?q=author%3AFilosso%2C%20Pier">Filosso, Pier</a>; </li><li><a href="/search/?q=author%3AFu%2C%20Xiangning">Fu, Xiangning</a>; </li><li><a href="/search/?q=author%3AForce%2C%20Seth">Force, Seth</a>; </li><li><a href="/search/?q=author%3AGarutti%2C%20Mart%C3%ADnez">Garutti, Mart铆nez</a>; </li><li><a href="/search/?q=author%3AGonzalez-Rivas%2C%20Diego">Gonzalez-Rivas, Diego</a>; </li><li><a href="/search/?q=author%3AGossot%2C%20Dominique">Gossot, Dominique</a>; </li><li><a href="/search/?q=author%3AHansen%2C%20Henrik">Hansen, Henrik</a>; </li><li><a href="/search/?q=author%3AHe%2C%20Jianxing">He, Jianxing</a>; </li><li><a href="/search/?q=author%3AHe%2C%20Jie">He, Jie</a>; </li><li><a href="/search/?q=author%3AHolbek%2C%20Bo">Holbek, Bo</a>; </li><li><a href="/search/?q=author%3AHu%2C%20Jian">Hu, Jian</a>; </li><li><a href="/search/?q=author%3AHuang%2C%20Yunchao">Huang, Yunchao</a>; </li><li><a href="/search/?q=author%3AIbrahim%2C%20Mohsen">Ibrahim, Mohsen</a>; </li><li><a href="/search/?q=author%3AImperatori%2C%20Andrea">Imperatori, Andrea</a>; </li><li><a href="/search/?q=author%3AIsmail%2C%20Mahmoud">Ismail, Mahmoud</a>; </li><li><a href="/search/?q=author%3AJiang%2C%20Gening">Jiang, Gening</a>; </li><li><a href="/search/?q=author%3AJiang%2C%20Hongjing">Jiang, Hongjing</a>; </li><li><a href="/search/?q=author%3AJiang%2C%20Zhongmin">Jiang, Zhongmin</a>; </li><li><a href="/search/?q=author%3AKim%2C%20Hyun">Kim, Hyun</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Danqing">Li, Danqing</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Gaofeng">Li, Gaofeng</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Hui">Li, Hui</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Qiang">Li, Qiang</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Xiaofei">Li, Xiaofei</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Yin">Li, Yin</a>; </li><li><a href="/search/?q=author%3ALi%2C%20Zhijun">Li, Zhijun</a>; </li><li><a href="/search/?q=author%3ALim%2C%20Eric">Lim, Eric</a>; </li><li><a href="/search/?q=author%3ALiu%2C%20Chia-Chuan">Liu, Chia-Chuan</a>; </li><li><a href="/search/?q=author%3ALiu%2C%20Deruo">Liu, Deruo</a>; </li><li><a href="/search/?q=author%3ALiu%2C%20Lunxu">Liu, Lunxu</a>; </li><li><a href="/search/?q=author%3ALiu%2C%20Yongyi">Liu, Yongyi</a>; </li><li><a href="/search/?q=author%3ALobdell%2C%20Kevin">Lobdell, Kevin</a>; </li><li><a href="/search/?q=author%3AMa%2C%20Haitao">Ma, Haitao</a>; </li><li><a href="/search/?q=author%3AMao%2C%20Weimin">Mao, Weimin</a>; </li><li><a href="/search/?q=author%3AMao%2C%20Yousheng">Mao, Yousheng</a>; </li><li><a href="/search/?q=author%3AMou%2C%20Juwei">Mou, Juwei</a>; </li><li><a href="/search/?q=author%3ANg%2C%20Calvin">Ng, Calvin</a>; </li><li><a href="/search/?q=author%3ANovoa%2C%20Nuria">Novoa, Nuria</a>; </li><li><a href="/search/?q=author%3APetersen%2C%20Ren%C3%A9">Petersen, Ren茅</a>; </li><li><a href="/search/?q=author%3AOizumi%2C%20Hiroyuki">Oizumi, Hiroyuki</a>; </li><li><a href="/search/?q=author%3APapagiannopoulos%2C%20Kostas">Papagiannopoulos, Kostas</a>; </li><li><a href="/search/?q=author%3APompili%2C%20Cecilia">Pompili, Cecilia</a>; </li><li><a href="/search/?q=author%3AQiao%2C%20Guibin">Qiao, Guibin</a>; </li><li><a href="/search/?q=author%3ARefai%2C%20Majed">Refai, Majed</a>; </li><li><a href="/search/?q=author%3ARocco%2C%20Gaetano">Rocco, Gaetano</a>; </li><li><a href="/search/?q=author%3ARuffini%2C%20Erico">Ruffini, Erico</a>; </li><li><a href="/search/?q=author%3ASalati%2C%20Michele">Salati, Michele</a>; </li><li><a href="/search/?q=author%3ASeguin-Givelet%2C%20Agathe">Seguin-Givelet, Agathe</a>; </li><li><a href="/search/?q=author%3ASihoe%2C%20Alan">Sihoe, Alan</a>; </li><li><a href="/search/?q=author%3ATan%2C%20Lijie">Tan, Lijie</a>; </li><li><a href="/search/?q=author%3ATan%2C%20Qunyou">Tan, Qunyou</a>; </li><li><a href="/search/?q=author%3ATong%2C%20Tang">Tong, Tang</a>; </li><li><a href="/search/?q=author%3ATsakiridis%2C%20Kosmas">Tsakiridis, Kosmas</a>; </li><li><a href="/search/?q=author%3AVenuta%2C%20Federico">Venuta, Federico</a>; </li><li><a href="/search/?q=author%3AVeronesi%2C%20Giulia">Veronesi, Giulia</a>; </li><li><a href="/search/?q=author%3AVillamizar%2C%20Nestor">Villamizar, Nestor</a>; </li><li><a href="/search/?q=author%3AWang%2C%20Haidong">Wang, Haidong</a>; </li><li><a href="/search/?q=author%3AWang%2C%20Qun">Wang, Qun</a>; </li><li><a href="/search/?q=author%3AWang%2C%20Ruwen">Wang, Ruwen</a>; </li><li><a href="/search/?q=author%3AWang%2C%20Shumin">Wang, Shumin</a>; </li><li><a href="/search/?q=author%3AWright%2C%20Gavin">Wright, Gavin</a>; </li><li><a href="/search/?q=author%3AXie%2C%20Deyao">Xie, Deyao</a>; </li><li><a href="/search/?q=author%3AXue%2C%20Qi">Xue, Qi</a>; </li><li><a href="/search/?q=author%3AXue%2C%20Tao">Xue, Tao</a>; </li><li><a href="/search/?q=author%3AXu%2C%20Lin">Xu, Lin</a>; </li><li><a href="/search/?q=author%3AXu%2C%20Shidong">Xu, Shidong</a>; </li><li><a href="/search/?q=author%3AXu%2C%20Songtao">Xu, Songtao</a>; </li><li><a href="/search/?q=author%3AYan%2C%20Tiansheng">Yan, Tiansheng</a>; </li><li><a href="/search/?q=author%3AYu%2C%20Fenglei">Yu, Fenglei</a>; </li><li><a href="/search/?q=author%3AYu%2C%20Zhentao">Yu, Zhentao</a>; </li><li><a href="/search/?q=author%3AZhang%2C%20Chunfang">Zhang, Chunfang</a>; </li><li><a href="/search/?q=author%3AZhang%2C%20Lanjun">Zhang, Lanjun</a>; </li><li><a href="/search/?q=author%3AZhang%2C%20Tao">Zhang, Tao</a>; </li><li><a href="/search/?q=author%3AZhang%2C%20Xun">Zhang, Xun</a>; </li><li><a href="/search/?q=author%3AZhao%2C%20Xiaojing">Zhao, Xiaojing</a>; </li><li><a href="/search/?q=author%3AZhao%2C%20Xuewei">Zhao, Xuewei</a>; </li><li><a href="/search/?q=author%3AZhi%2C%20Xiuyi">Zhi, Xiuyi</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AZhou%2C%20Qinghua">Zhou, Qinghua</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucd_postprints">UC Davis Previously Published Works</a> (2017)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">The Society for Translational Medicine and The Chinese Society for Thoracic and Cardiovascular Surgery conducted a systematic review of the literature in an attempt to improve our understanding in the postoperative management of chest tubes of patients undergoing pulmonary lobectomy. Recommendations were produced and classified based on an internationally accepted GRADE system. The following recommendations were extracted in the present review: (I) chest tubes can be removed safely with daily pleural fluid of up to 450 mL (non-chylous and non-sanguinous), which may reduce chest tube duration and hospital length of stay (2B); (II) in rare instances, e.g., persistent abundant fluid production, the use of PrRP/B <0.5 when evaluating fluid output to determine chest tube removal might be beneficial (2B); (III) it is recommended that one chest tube is adequate following pulmonary lobectomy, except for hemorrhage and space problems (2A); (IV) chest tube clearance by milking and stripping is not recommended after lung resection (2B); (V) chest tube suction is not necessary for patients undergoing lobectomy after first postoperative day (2A); (VI) regulated chest tube suction [-11 (-1.08 kPa) to -20 (1.96 kPa) cmH2O depending upon the type of lobectomy] is not superior to regulated seal [-2 (0.196 kPa) cmH2O] when electronic drainage systems are used after lobectomy by thoracotomy (2B); (VII) chest tube removal recommended at the end of expiration and may be slightly superior to removal at the end of inspiration (2A); (VIII) electronic drainage systems are recommended in the management of chest tube in patients undergoing lobectomy (2B).</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/0hv6s32x"><img src="/cms-assets/806489c78f75b02e4dfe8776cf5bdd5f148ed79844aa5c57fdf416e5e409032f" alt="Cover page: The Society for Translational Medicine: clinical practice guidelines for the postoperative management of chest tube for patients undergoing lobectomy."/></a></div></section></section></main></form></div><div><div class="c-toplink"><a href="javascript:window.scrollTo(0, 0)">Top</a></div><footer class="c-footer"><nav class="c-footer__nav"><ul><li><a href="/">Home</a></li><li><a href="/aboutEschol">About eScholarship</a></li><li><a href="/campuses">Campus Sites</a></li><li><a href="/ucoapolicies">UC Open Access Policy</a></li><li><a href="/publishing">eScholarship Publishing</a></li><li><a href="https://www.cdlib.org/about/accessibility.html">Accessibility</a></li><li><a href="/privacypolicy">Privacy Statement</a></li><li><a href="/policies">Site Policies</a></li><li><a href="/terms">Terms of Use</a></li><li><a href="/login"><strong>Admin Login</strong></a></li><li><a href="https://help.escholarship.org"><strong>Help</strong></a></li></ul></nav><div class="c-footer__logo"><a href="/"><img class="c-lazyimage" data-src="/images/logo_footer-eschol.svg" alt="eScholarship, University of California"/></a></div><div class="c-footer__copyright">Powered by the<br/><a href="http://www.cdlib.org">California Digital Library</a><br/>Copyright 漏 2017<br/>The Regents of the University of California</div></footer></div></div></div></div> <script src="/js/vendors~app-bundle-2aefc956e545366a5d4e.js"></script> <script src="/js/app-bundle-3c8ebc2ec05dcc3202fd.js"></script> </body> </html>