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category-breast-cancer tag-breast-cancer tag-cancer-genome-atlas tag-chemotherapy tag-high-tumor tag-novel-chemotherapy" itemtype="https://schema.org/CreativeWork" itemscope> <div class="inside-article"> <div class="featured-image page-header-image-single "> <img width="1200" height="628" src="https://cancerscience.net/archive/wp-content/uploads/2024/09/breast-cancer-16-min-scaled-e1725626382564.jpg" class="attachment-full size-full" alt="" itemprop="image" decoding="async" fetchpriority="high" /> </div> <header class="entry-header"> <h1 class="entry-title" itemprop="headline">Innovations in Breast Cancer Treatment</h1> <div class="entry-meta"> <span class="posted-on"><time class="updated" datetime="2024-09-06T18:10:30+05:30" itemprop="dateModified">September 6, 2024</time><time class="entry-date published" datetime="2024-09-03T12:54:18+05:30" itemprop="datePublished">September 3, 2024</time></span> <span class="byline">by <span class="author vcard" itemprop="author" itemtype="https://schema.org/Person" itemscope><a class="url fn n" href="https://cancerscience.net/archive/author/cancerscience/" title="View all posts by cancerscience" rel="author" itemprop="url"><span class="author-name" itemprop="name">cancerscience</span></a></span></span> </div> </header> <div class="entry-content" itemprop="text"> <p><span style="font-weight: 400;">Breast cancer remains one of the most common and complicated diseases to date, which poses a threat to a huge number of female and male populations. Thus, it is essential to note that substantial progress has been made in a better understanding of the biology of breast cancer over the years, resulting in new therapeutic approaches promoting better patient outcomes and quality of life. Read on for the latest developments in breast cancer that bring hope to women through new potent drugs, state-of-the-art technologies, and advanced clinical trials.</span></p> <h3><b>Advancements in Immunotherapy</b></h3> <p><span style="font-weight: 400;">Immunotherapy has changed the face of cancer treatment by using the body’s immune system to tackle cancer cells. Among the main developments in the therapy of breast cancer, it is possible to allocate the usage of pembrolizumab as an anti-PD-1 antibody. Pembrolizumab has demonstrated excellent outcomes in the treatment of breast cancer positive for PD-L1, which also failed to respond to chemotherapy. Thus, clinical trials have revealed that with the help of pembrolizumab, patients indicated a high degree of tumor reduction and an increased survival rate. This therapy operates under the principle that by preventing the utilization of the PD-1 pathway that cancer cells use to avoid detection from the natural immune system, an individual’s immune cells will be able to effectively kill the cancer cells.</span></p> <h3><b>Targeted Therapy with Trastuzumab Deruxtecan</b></h3> <p><span style="font-weight: 400;">Herceptin derivative trastuzumab deruxtecan (DS-8201) is considered a completely new class of targeted therapy for HER2-positive breast cancer. This is a type of targeted drug that combines the ability of an antibody that binds to HER-2 with a chemotherapy drug to treat the cancer. Hearing about the clinical trials, trastuzumab deruxtecan has reported spectacular outcomes in those patients who had received prior lines of HER2-targeted treatments. In addition to improving progression-free survival, the therapy also had a high objective response rate, which makes it ideal for advanced HER2-positive breast cancer patients.</span></p> <h3><b>Combination Therapies: Ribociclib and Fulvestrant</b></h3> <p><span style="font-weight: 400;">In combination with the CDK4/6 inhibitor ribociclib, overall survival has been increased in patients with HR-positive, HER2-negative advanced breast cancer to treatment with the endocrine therapy fulvestrant. It combines agents that affect the mitotic cycle of cancer cells and the endocrine activity, which helps to limit the further advancement of the tumor. Investigations in oncology practice have shown that the patients who underwent treatment with ribociclib in combination with fulvestrant had a higher overall survival time than the patients under treatment rate, fulvestrant only. This combination therapy is specifically recommended for premenopausal and perimenopausal patients; it is considered a new reference model for breast cancer treatment in these groups of patients.</span></p> <p></div></div> <div style="background: #f7f7f7;border: 1px solid rgba(0, 0, 0, 0.07);"> <div style="padding: 30px;"><div class="Adblock-main"> <div class="Adblock-head"> <h2>Yearwise Publication Trend on <b>“<a href="https://cancerscience.net/publication-trends/index/breast cancer" target="_blank" title="breast cancer - yearwise publication trends">breast cancer</a>”</b></h2> </div> </div><div class="results-container"><div class="chart-block" style="padding:15px;"> <div class="left"> <div id="results" class="results"></div> </div> <div class="right"> <div class="chart-container"><canvas id="publicationChart"></canvas></div> </div> <div class="keywordsdiv"> <div style="text-align:center;"><b>Find publication trends on relevant topics</b> </div> <span class="gp-icon icon-tags"><svg viewBox="0 0 512 512" aria-hidden="true" xmlns="http://www.w3.org/2000/svg" width="1em" height="1em"><path d="M20 39.5c-8.836 0-16 7.163-16 16v176c0 4.243 1.686 8.313 4.687 11.314l224 224c6.248 6.248 16.378 6.248 22.626 0l176-176c6.244-6.244 6.25-16.364.013-22.615l-223.5-224A15.999 15.999 0 00196.5 39.5H20zm56 96c0-13.255 10.745-24 24-24s24 10.745 24 24-10.745 24-24 24-24-10.745-24-24z"></path><path d="M259.515 43.015c4.686-4.687 12.284-4.687 16.97 0l228 228c4.686 4.686 4.686 12.284 0 16.97l-180 180c-4.686 4.687-12.284 4.687-16.97 0-4.686-4.686-4.686-12.284 0-16.97L479.029 279.5 259.515 59.985c-4.686-4.686-4.686-12.284 0-16.97z"></path></svg></span> <span id="keyword-stats"></span> </div> </div></div></div><div class="inside-article"><style> table { margin: 0 0 1.5em; 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if (!statistics || Object.keys(statistics).length === 0) { resultsContainer.innerHTML = '<p>No data found.</p>'; return; } var tableHTML = `<div class='pub-scroll'> <table class='tablediv' border='1' cellspacing='0' cellpadding='0'> <tr> <th>Year</th> <th>Publication Count</th> </tr>`; Object.entries(statistics).sort(([yearA], [yearB]) => yearB - yearA).forEach(([year, count]) => { const displayCount = count === 0 ? 'NA' : count; tableHTML += ` <tr> <td>${year}</td> <td>${displayCount}</td> </tr> `; }); tableHTML += '</table></div>'; resultsContainer.innerHTML = tableHTML; } function displayLineChart(statistics) { var years = Object.keys(statistics); var counts = Object.values(statistics); var ctx = document.getElementById('publicationChart').getContext('2d'); // Destroy existing chart instance if it exists if (chart !== null) { chart.destroy(); } // Create a new chart instance chart = new Chart(ctx, { type: 'line', data: { labels: years, datasets: [{ label: 'Publication Counts', data: counts, fill: false, borderColor: 'rgba(75, 192, 192, 1)', tension: 0.1 }] }, options: { scales: { y: { beginAtZero: true } }, plugins: { legend: { display: true, position: 'top' } } } }); } function displayKeywordStats(keywords) { var resultsContainer = document.getElementById('keyword-stats'); resultsContainer.innerHTML = ''; if (!keywords || keywords.length === 0) { resultsContainer.innerHTML = '<p>No data found.</p>'; return; } var keywordHTML = ''; keywords.forEach((key, index) => { let key_replace = key.replace(/ /g, '-'); key_replace = key_replace.toLowerCase(); keywordHTML += `<a href="https://cancerscience.net/publication-trends/index/${key_replace}" target="_blank" title="${key} - yearwise publication trends">${key}</a>`; if (index < keywords.length - 1) { keywordHTML += ', '; } }); resultsContainer.innerHTML = keywordHTML; } // Call the function with the PHP data var statistics = { "2014": 9421, "2015": 8725, "2016": 10770, "2017": 10715, "2018": 11567, "2019": 14113, "2020": 17898, "2021": 20133, "2022": 24166, "2023": 39213, "2024": 13254 }; var keywordsArray = ["Breast cancer","chemotherapy","scalp cooling","HER2-positive","triple-negative breast cancer","tumor mutational burden"]; displayResults(statistics); displayLineChart(statistics); displayKeywordStats(keywordsArray); </script></p> <h3><b>Scalp Cooling to Prevent Chemotherapy-Induced Alopecia</b></h3> <p><span style="font-weight: 400;">Hair loss is among the leading tumors in patients receiving chemotherapy for breast cancer, yet there is no Whicher, 2003; Blaylock & Moore, 2004; Nokalo et al., 2005; Seidman et al., 2002; Stewart & Moore, 2002 & Yoo et al., 2005; Scalp cooling devices, for example. DigniCap® has been found to prevent hair loss during chemotherapy. Research has proved that the option of scalp cooling can significantly prevent the occurrence of alopecia in patients taking neoadjuvant or adjuvant chemotherapy for early breast cancer. These apparatuses cool the scalp, which causes the blood vessels to shrink and thus decrease the amount of chemotherapy agents that can be absorbed by the hair shafts and thus retain hair. Besides, it contributes effectively to the physical appearance of the patient and their psychological state during the treatment process.</span></p> <h3><b>Novel Chemotherapy Regimens</b></h3> <p><span style="font-weight: 400;">New combinations of chemotherapy, however, remain an essential component of the therapy for breast cancer. The design neratinib is an irreversible pan-HER tyrosine kinase inhibitor, and the concurrent use of capecitabine has depicted a favorable response in patients of HER2-positive metastatic breast cancer bearing multiple prior HER2-directed regimens. These treatments have shown enhanced progression-free survival and deferred time to the development of intervention for symptomatic CNS disease than the conventional methods. In this study, the main emphasis was placed on the possible optimization of chemotherapy regimens to improve the survival rates in advanced BC cases.</span></p> <h3><b>Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer</b></h3> <p><span style="font-weight: 400;">TNBC is a very deadly type of breast cancer that has several features and few treatment modalities. Molecules like atezolizumab fall under the immune checkpoint inhibitors that can act against TNBC by selectively targeting the PD-L1 pathway. The OS potential shoulder in the IMpassion130 study furnished evidence that atezolizumab together with nab-paclitaxel enhanced progression-free survival of PD-L1-positive TNBC patients. Further, the combination therapy stands to operate on a mechanism that strengthens the ability of the body’s immune system to detect and destroy the cancer cells, giving patients with this difficult subtype of breast cancer hope.</span></p> <p></div></div> <div style="background: #f7f7f7;border: 1px solid rgba(0, 0, 0, 0.07);"> <div style="padding: 30px;"><div class="Adblock-main"> <div class="Adblock-head"> <h2>Recent Publications on <b>“<a href="https://cancerscience.net/recent-publications/index/breast cancer" target="_blank" rel="noopener" title="breast cancer - yearwise publication list">breast cancer</a>”</b></h2> </div> </div> <div class="pb-main"><div class="article-scroll"><div id="results_recent" class="results"></div></div><div class="keywordsdiv" style="margin: 0px 15px;margin-top:20px;"> <div style="text-align:center;"><b>Find publications on relevant topics</b> </div> <span class="gp-icon icon-tags"><svg viewBox="0 0 512 512" aria-hidden="true" xmlns="http://www.w3.org/2000/svg" width="1em" height="1em"><path d="M20 39.5c-8.836 0-16 7.163-16 16v176c0 4.243 1.686 8.313 4.687 11.314l224 224c6.248 6.248 16.378 6.248 22.626 0l176-176c6.244-6.244 6.25-16.364.013-22.615l-223.5-224A15.999 15.999 0 00196.5 39.5H20zm56 96c0-13.255 10.745-24 24-24s24 10.745 24 24-10.745 24-24 24-24-10.745-24-24z"></path><path d="M259.515 43.015c4.686-4.687 12.284-4.687 16.97 0l228 228c4.686 4.686 4.686 12.284 0 16.97l-180 180c-4.686 4.687-12.284 4.687-16.97 0-4.686-4.686-4.686-12.284 0-16.97L479.029 279.5 259.515 59.985c-4.686-4.686-4.686-12.284 0-16.97z"></path></svg></span> <span id="keyword-papers"></span> </div></div></div><div class="inside-article"> <style> .pb-main{ border: solid 1px #ccc; border-top: none; margin-bottom: 20px; padding-bottom: 25px; background:#fff; } .author-main { border: solid 1px #ccc; border-top: none; margin-bottom: 20px; padding-bottom: 25px; background:#fff; } .publication-block { padding: 10px; margin-bottom: 10px; background-color: #f9f9f9; text-align: left; background: #FFF; border-bottom: solid 1px #ccc; margin-left: 15px; margin-right: 15px; } .publication-block h3 { margin: 0 0 10px; color: #000!important; } .publication-block a { font-size: 16px !important; line-height: 1em; font-weight: 600; text-transform: none; color: #000; padding: 0px; } .publication-block a:hover{ color: #227cdc; text-decoration:underline; } .article-scroll { max-height: 445px; overflow-y: auto; overflow-x: hidden; } ::-webkit-scrollbar-track { -webkit-box-shadow: inset 0 0 6px rgba(0,0,0,0.3); background-color: #efefef; border-radius:30px; } ::-webkit-scrollbar { width: 6px; background-color: #efefef; border-radius:30px; } ::-webkit-scrollbar-thumb { background-color: #ababab; border-radius:30px; } .publication-block p { margin-bottom: .5em; font-size: 15px; color: #000; } h3 { font-size: 18px !important; margin-bottom: 20px; line-height: 1.2em; font-weight: 600; text-transform: none; } a { padding: 5px; color: #a71c49; } #keyword-papers{ margin-top: 20px; text-align: center; } </style> <script> function displayResults_recent(papers) { var resultsContainer = document.getElementById('results_recent'); if (!papers || papers.length === 0) { resultsContainer.innerHTML = '<p>No recent publications found.</p>'; return; } papers.forEach(paper => { var publicationBlock = document.createElement('div'); publicationBlock.className = 'publication-block'; var publicationHTML = ` <div style="margin-bottom: 10px;line-height: 24px;"><a href="${paper.url}" target="_blank" title="${paper.title}">${paper.title}</a></div> <p><strong>Issue Release:</strong> ${paper.publishedDate}</p> `; publicationBlock.innerHTML = publicationHTML; resultsContainer.appendChild(publicationBlock); }); } function displayKeywordPapers(keywords) { var resultsContainer = document.getElementById('keyword-papers'); resultsContainer.innerHTML = ''; if (!keywords || keywords.length === 0) { resultsContainer.innerHTML = '<p>No data found.</p>'; return; } var keywordHTML = ''; keywords.forEach((key, index) => { let key_replace = key.replace(/ /g, '-'); key_replace = key_replace.toLowerCase(); keywordHTML += `<a href="https://cancerscience.net/recent-publications/index/${key_replace}" target="_blank" title="${key} - publication list">${key}</a>`; if (index < keywords.length - 1) { keywordHTML += ', '; } }); resultsContainer.innerHTML = keywordHTML; } // Call the function with the PHP data var recent_papers = [ { "title": "[Pharmacological properties and clinical development overview of pertuzumab (genetical recombination), trastuzumab (genetical recombination) and vorhyaluronidase alfa (genetical recombination) (PHESGO combination for \u200dsubcutaneous injection MA, IN)].", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38945908", "publishedDate": "2024" }, { "title": "Systemic oncological therapy in breast cancer patients on dialysis.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38946836", "publishedDate": "2024" }, { "title": "Niraparib Maintenance Therapy for Brain Metastasis in Ovarian Endometrioid Adenocarcinoma With Peritoneal Carcinomatosis: A Comprehensive Case Study and Literature Review.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38947662", "publishedDate": "2024" }, { "title": "Trametinib boosts palbociclib\\\\\\'s efficacy in breast cancer via autophagy inhibition.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38948022", "publishedDate": "2024" }, { "title": "Injectable nano-in situ-thermosensitive-hydrogels based on halofuginone and silver for postoperative treatment against triple-negative breast cancer.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38917957", "publishedDate": "2024" }, { "title": "Tetrastigma hemsleyanum polysaccharide combined with doxorubicin promote ferroptosis and immune function in triple-negative breast cancer.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38945330", "publishedDate": "2024" }, { "title": "Changes in experienced quality of oncological cancer care during the COVID-19 pandemic based on patient reported outcomes - a cross-sectional study.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38946287", "publishedDate": "2024" }, { "title": "Retraction: Extracellular vesicles carry lncRNA SNHG16 to promote metastasis of breast cancer cells via the miR-892b\/PPAPDC1A axis.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38946795", "publishedDate": "2024" }, { "title": "Role of Psychosomatic Medicine in Complex Medical Cases: A Case Study of a Patient With Breast Cancer Who Refused Mastectomy.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38947634", "publishedDate": "2024" }, { "title": "G protein pathway suppressor 2 suppresses aerobic glycolysis through RACK1-mediated HIF-1\u03b1 degradation in breast cancer.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38942092", "publishedDate": "2024" }, { "title": "A critical appraisal of the role of metabolomics in breast cancer research and diagnostics.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38944408", "publishedDate": "2024" }, { "title": "Carbon chain length in a novel anticancer aryl-urea fatty acid modulates mitochondrial targeting, reactive oxygen species production and cell killing.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38945837", "publishedDate": "2024" }, { "title": "Shared genetics between breast cancer and predisposing diseases identifies novel breast cancer treatment candidates.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38947022", "publishedDate": "2024" }, { "title": "The Gene Expression Landscape of Disease Genes.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38947033", "publishedDate": "2024" }, { "title": "Circulating cell-free (cf)DNA analysis: Current technologies and applications in gynecologic cancer.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38947418", "publishedDate": "2024" }, { "title": "Electroacupuncture Facilitates Vascular Normalization by Inhibiting Glyoxalase1 in Endothelial Cells to Attenuate Glycolysis and Angiogenesis in Triple-Negative Breast Cancer.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38945204", "publishedDate": "2024" }, { "title": "Establishment of a humanized mouse model using steady-state peripheral blood-derived hematopoietic stem and progenitor cells facilitates screening of cancer-targeted T-cell repertoires.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38947755", "publishedDate": "2024" }, { "title": "Author response: advancing targeted axillary dissection in node-positive breast cancer: insights from pooled analyses and systematic review.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38953506", "publishedDate": "2024" }, { "title": "ACSL3 regulates breast cancer progression lipid metabolism reprogramming and the YES1\/YAP axis.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38953696", "publishedDate": "2024" }, { "title": "GSDME-mediated pyroptosis promotes anti-tumor immunity of neoadjuvant chemotherapy in breast cancer.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38954046", "publishedDate": "2024" } ]; var keywordsArray = ["Breast cancer","chemotherapy","scalp cooling","HER2-positive","triple-negative breast cancer","tumor mutational burden"]; displayResults_recent(recent_papers); displayKeywordPapers(keywordsArray); </script></p> <h3><b>The Role of High Tumor Mutational Burden</b></h3> <p><span style="font-weight: 400;">Recent studies have revealed that tumor mutational burden, or HTMB, can be used as a possible biomarker to design immune checkpoint inhibitors in breast cancer. According to existing research, the use of pembrolizumab as a treatment for metastatic breast cancer and HTMB has proved effective and has demonstrated a strong anti-tumor effect. HTMB implies increased numbers of mutations within the tumor, thus it is more recognizable by the immune system. when the patient is treated with immune checkpoint inhibitors. This discovery is important to breast cancer treatment, in which therapies are developed under the tumor’s molecular analysis.</span></p> <h3><b>Advances in HER2-Targeted Therapies</b></h3> <p><span style="font-weight: 400;">HER2-targeted therapies have therefore brought a dramatic change in the management of HER2-positive breast cancer. Apart from trastuzumab deruxtecan, other promising agents such as pertuzumab together with trastuzumab have proved clinically effective. The TAPUR study has shown the efficiency of this combination in patients with ERBB2 amplification or overexpression; significant tumor control and better survival rates have been provided. Such progress underscores the importance of HER2-targeted treatments for HER2-positive breast cancer and patients’ outcomes.</span></p> <h3><b>Exploring New Frontiers with Ribociclib</b></h3> <p><span style="font-weight: 400;">Ribociclib in combination with several endocrine agents remains a hope for increasing survival for female patients with advanced breast cancer. Current research has shifted to looking for ways through which ribociclib can be used together with other agents to increase efficacy. For instance, when ribociclib was used in conjunction with tamoxifen, it increased progression-free survival in premenopausal women suffering from hormone-receptor-positive, HER2-negative advanced breast cancer. From such findings, one can state that ribociclib-based combinations might lay the foundation for further treatment approaches in cases with advanced breast cancer and, thus, give a new shot at survival to individuals who do have not many choices left.</span></p> <h3><b>Future Directions and Ongoing Research</b></h3> <p><span style="font-weight: 400;">The treatment of breast cancer in particular is rapidly changing; there are many open trials to study new treatments and their combinations. Breast cancer is considered to be treatable as more and more novel immune checkpoint inhibitors, targeted therapies, and combinations of regimens are being researched to improve the treatment outcomes. Also, the growth of more accurate diagnostic tools for genetic profiling and the theme of precision medicine is breaking through the barriers of future remedies. Each of these young technologies promises to change the modality of treating breast cancer and enhance the lives of millions of patients diagnosed with this malignant disease</span><span style="font-weight: 400;">.</span></p> <h3><b>Conclusion</b></h3> <p><span style="font-weight: 400;">In recent years, progress in understanding the biological characteristics of breast cancer and new approaches to its treatment has been marked. Abbreviated as IO, I&T, NT, and IO&-HT, these advancements are transforming the primary and adjuvant therapy of breast cancer. In light of recent discoveries, the search for a cure and better quality of life among affected breast cancer patients gets closer to realization.</span></p> <p></p> <h3><b>References</b></h3> <ol> <li>Phan, K. and Charif, M., 2020. <a href="https://journals.lww.com/americantherapeutics/citation/2020/12000/pembrolizumab_for_pd_l1_positive_breast_cancer.13.aspx">Pembrolizumab for PD-L1–Positive Breast Cancer Refractory to Chemotherapy.</a> <i>American Journal of Therapeutics</i>, <i>27</i>(6), pp.e622-e624.</li> <li> <div class="citation-text">Modi S, Saura C, Yamashita T, Park YH, Kim SB, Tamura K, Andre F, Iwata H, Ito Y, Tsurutani J, Sohn J, Denduluri N, Perrin C, Aogi K, Tokunaga E, Im SA, Lee KS, Hurvitz SA, Cortes J, Lee C, Chen S, Zhang L, Shahidi J, Yver A, Krop I; DESTINY-Breast01 Investigators. <a href="https://pubmed.ncbi.nlm.nih.gov/31825192/">Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer.</a> N Engl J Med. 2020 Feb 13;382(7):610-621. doi: 10.1056/NEJMoa1914510. Epub 2019 Dec 11. PMID: 31825192; PMCID: PMC7458671.</div> </li> <li> <div class="citation-text">Slamon DJ, Neven P, Chia S, Fasching PA, De Laurentiis M, Im SA, Petrakova K, Bianchi GV, Esteva FJ, Martín M, Nusch A, Sonke GS, De la Cruz-Merino L, Beck JT, Pivot X, Sondhi M, Wang Y, Chakravartty A, Rodriguez-Lorenc K, Taran T, Jerusalem G. <a href="https://pubmed.ncbi.nlm.nih.gov/31826360/">Overall Survival with Ribociclib plus Fulvestrant in Advanced Breast Cancer.</a> N Engl J Med. 2020 Feb 6;382(6):514-524. doi: 10.1056/NEJMoa1911149. Epub 2019 Dec 11. PMID: 31826360.</div> </li> <li> <div class="citation-text">Giarratano T, Frezzini S, Zanocco M, Giorgi CA, Mioranza E, Miglietta F, Griguolo G, Falci C, Faggioni G, Tasca G, Di Liso E, Vernaci G, Menichetti A, Mantiero M, Grosso D, Guarneri V, Dieci MV. <a href="https://pubmed.ncbi.nlm.nih.gov/31837103/">Use of scalp cooling device to prevent alopecia for early breast cancer patients receiving chemotherapy: A prospective study.</a> Breast J. 2020 Jul;26(7):1296-1301. doi: 10.1111/tbj.13711. Epub 2019 Dec 14. PMID: 31837103.</div> </li> <li> <div class="citation-text">Saura C, Oliveira M, Feng YH, Dai MS, Chen SW, Hurvitz SA, Kim SB, Moy B, Delaloge S, Gradishar W, Masuda N, Palacova M, Trudeau ME, Mattson J, Yap YS, Hou MF, De Laurentiis M, Yeh YM, Chang HT, Yau T, Wildiers H, Haley B, Fagnani D, Lu YS, Crown J, Lin J, Takahashi M, Takano T, Yamaguchi M, Fujii T, Yao B, Bebchuk J, Keyvanjah K, Bryce R, Brufsky A; NALA Investigators. <a href="https://pubmed.ncbi.nlm.nih.gov/32678716/">Neratinib Plus Capecitabine Versus Lapatinib Plus Capecitabine in HER2-Positive Metastatic Breast Cancer Previously Treated With ≥ 2 HER2-Directed Regimens: Phase III NALA Trial.</a> J Clin Oncol. 2020 Sep 20;38(27):3138-3149. doi: 10.1200/JCO.20.00147. Epub 2020 Jul 17. PMID: 32678716; PMCID: PMC7499616.</div> </li> <li> <div class="citation-text">Alva AS, Mangat PK, Garrett-Mayer E, Halabi S, Hansra D, Calfa CJ, Khalil MF, Ahn ER, Cannon TL, Crilley P, Fisher JG, Haslem DS, Shrestha S, Antonelli KR, Butler NL, Warren SL, Rygiel AL, Ranasinghe S, Bruinooge SS, Schilsky RL. <a href="https://pubmed.ncbi.nlm.nih.gov/33844595/">Pembrolizumab in Patients With Metastatic Breast Cancer With High Tumor Mutational Burden: Results From the Targeted Agent and Profiling Utilization Registry (TAPUR) Study</a>. J Clin Oncol. 2021 Aug 1;39(22):2443-2451. doi: 10.1200/JCO.20.02923. Epub 2021 Apr 12. PMID: 33844595.</div> </li> <li> <div class="citation-text">Gupta R, Meric-Bernstam F, Rothe M, Garrett-Mayer E, Mangat PK, D’Andre S, Ahn ER, O’Lone R, Halabi S, Grantham GN, Schilsky RL. <a href="https://pubmed.ncbi.nlm.nih.gov/36315917/">Pertuzumab Plus Trastuzumab in Patients With Colorectal Cancer With <i>ERBB2</i> Amplification or <i>ERBB2/3</i> Mutations: Results From the TAPUR Study.</a> JCO Precis Oncol. 2022 Oct;6:e2200306. doi: 10.1200/PO.22.00306. PMID: 36315917.</div> <div class="citation-actions"></div> </li> </ol> <p></div></div> <div style="background: #f7f7f7;border: 1px solid rgba(0, 0, 0, 0.07);"> <div style="padding: 30px;"><div class="Adblock-main"> <div class="Adblock-head"> <h2>Top Experts on “<b style="color:#000;font-size:22px;">breast cancer</b>“</h2> </div> </div><div class="author-main"><div id="results_author"></div><div style="text-align: center;"><a class="register-button" href="https://cancerscience.net/expert-search" target="_blank" rel="noopener">Find experts on any field</a></div></div><div class="inside-article" style="background: none;border: none;box-shadow: none;margin-top: -70px;"> <style> .author-block { padding: 15px; margin-bottom: 10px; text-align: left; font-size: 15px; line-height: 1.2; background: #FFF; border-bottom: solid 1px #ccc; margin-left: 15px; margin-right: 15px; } .author-block h3 { margin: 0 0 10px; color: #227cdc; } .author-block p { margin: 5px 0; } .author-b { display: flex; justify-content: space-between; flex-wrap: wrap; margin-bottom:10px; } .author-b .ainfo { flex: 1 1 30%; box-sizing: border-box; text-align: left; background: #dcdcdc; padding: 7px 14px; border-radius: 5px; margin-top: 3px; margin-right: 10px; } @media (max-width: 768px) { .author-b .ainfo { flex: 1 1 100%; margin: 10px 0; } } </style> <script> function displayResults_author(authors) { var resultsContainer = document.getElementById('results_author'); resultsContainer.innerHTML = ''; if (!authors || Object.keys(authors).length === 0) { resultsContainer.innerHTML = '<p>No authors found.</p>'; return; } Object.values(authors).slice(0, 10).forEach(author => { var authorBlock = document.createElement('div'); authorBlock.className = 'author-block'; var author_name=author.name; let key_replace = author_name.replace(/ /g, '-'); key_replace = key_replace.toLowerCase(); var authorHTML = ` <h3><a href="https://cancerscience.net/author/index/${key_replace}\/${author.aid}" target="_blank" title="${author.name}">${author.name}</a></h3> <div class="author-b"> <div class="ainfo"><strong>H-Index:</strong> ${author.hindex}</div> <div class="ainfo"><strong>Publication Count:</strong> ${author.paper_count}</div> <div class="ainfo"><strong>Citation Count:</strong> ${author.citation_count}</div> </div> <p><strong>Affiliation:</strong> ${author.affiliation}</p> `; authorBlock.innerHTML = authorHTML; resultsContainer.appendChild(authorBlock); }); } function displayKeywordAuthors(keywords) { var resultsContainer = document.getElementById('keyword-authors'); resultsContainer.innerHTML = ''; if (!keywords || keywords.length === 0) { resultsContainer.innerHTML = '<p>No data found.</p>'; return; } var keywordHTML = ''; keywords.forEach(key => { let key_replace = key.replace(/ /g, '-'); key_replace = key_replace.toLowerCase(); keywordHTML += `<a href="https://cancerscience.net/expert-search/index/${key_replace}" target="_blank" title="${key}">${key}</a>`; }); resultsContainer.innerHTML = keywordHTML; } // Call the function with the PHP data var authors_data = { "S8z3KowBWBy50K-rcYKU": { "aid": "S8z3KowBWBy50K-rcYKU", "name": "E. 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