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#main-header-landing.main-header-landing-video .center .container-inner{ padding-top:0; } } </style> <div id="main-header-landing" class="main-header-landing-video" aria-label="Site" itemtype="https://schema.org/WPHeader" itemscope=""> <video id="background-video" autoplay="" loop="" muted="" poster=""><source src="https://www.reactionbiology.com/wp-content/uploads/2024/06/btk-and-immune-diseases.mp4" type="video/mp4"></video> <div class="header-lp header-related fh-relateddHeader"> <div class="center"> <div class="container"> <div class="banner_content_wrap"> <div class="banner_content_inner"> <div class="container-inner"> <div class="banner-content-inner"> <h1>Your Trusted Partner for<br /> Kinase Drug Development</h1> <h5>Unlock the full potential of your kinase inhibitors with our integrated platform</h5> <p>With over 20 years of expertise in kinase biology, we can drive the success of your kinase inhibitors. Leverage our comprehensive biochemical, <i>in vitro</i>, and <i>in vivo</i> services for every stage of your preclinical pipeline.</p> <div class="button_group"><a class="btn white contact-popup" href="#">Contact Us </a></div> </div> </div> </div> </div> </div> </div> </div> </div>  <div id="et-main-area"> <div id="main-content"> <div id="block-proquinase-content" class="color-scheme-green block block-system block-system-main-block"> <article id="post-8485" class="post-8485 page type-page status-publish hentry" itemtype="https://schema.org/CreativeWork" itemscope=""> <div class="node__content"> <div id="bd-managers_anchor" class="paragraph weiss black paragraph--type--paragraph-container paragraph--view-mode--default"> <span id="bd-managers" class="anchor"></span> <div class="paragraph text-top-center images-0 headline-center paragraph--type--text-with-image paragraph--view-mode--default"> <div class="center container"> <div class="text-wrapper"> </div> </div> </div> <div id="_anchor" class="paragraph weiss black paragraph--paragraph-container-lp paragraph--type--paragraph-container paragraph--view-mode--default"> <div id="SecId_1" class="paragraph hadding-green header-no-border paragraph--type--text-with-image paragraph--view-mode--default" style="background-color:#ffffff"> <div class="container center"> <div class="text-wrapper"> <h2 style="text-align: center;"><strong>We support every step of your kinase drug development</strong></h2> <div class="d-none d-md-show"> <div class="steps-wrap-container-inimation flex"> <div class="steps_init_section" onload="steps_init();" style="margin:0px;"> <div id="animation_container" style="background-color:rgba(255, 255, 255, 1.00); width:1970px; height:325px; margin-bottom: 30px;"> <canvas id="canvas" width="1970" height="325" style="position: absolute; display: block; background-color:rgba(255, 255, 255, 1.00);"></canvas> <div id="dom_overlay_container" style="pointer-events:none; overflow:hidden; width:1970px; height:325px; position: absolute; left: 0px; top: 0px; display: block;"> </div> </div> </div> </div> </div> <div class="d-none d-sm-show"> <div class="steps-wrap-container-inimation flex"> <div class="steps_init_section" onload="steps_vertical_init();" style="margin:0px;"> <div id="animation_container_mobile" style="background-color:rgba(255, 255, 255, 1.00); width:325px; height:1900px"> <canvas id="canvas_mobile" width="325" height="1900" style="position: absolute; display: block; background-color:rgba(255, 255, 255, 1.00);"></canvas> <div id="dom_overlay_container_mobile" style="pointer-events:none; overflow:hidden; width:325px; height:1900px; position: absolute; left: 0px; top: 0px; display: block;"> </div> </div> </div> </div> </div> </div> </div> </div> <div id="SecId_2" class="paragraph hadding-green header-no-border paragraph--type--text-with-image paragraph--view-mode--default" style="background-color:#ffffff"> <div class="container center"> <div class="text-wrapper"> <h2 id="EvaluateKinaseActivity">Evaluate Kinase Activity</h2> <h4><strong>Uncover the inhibitory effect of your compound on its target kinase with precision</strong></h4> <p>Leverage our high-throughput screening capabilities and diverse detection methods (radiometric, fluorescent, luminescent) to identify promising leads. Interested in testing smaller size libraries, such as a fragment library, a focused library, or an FDA drug collection library instead? Ask us about our <a href="https://www.reactionbiology.com/services/biophysical-assays/surface-plasmon-resonance-spr" target="_blank" rel="noopener">SPR screening</a> services.</p> </div> </div> </div> <div id="SecId_3" class="paragraph two_columns pb5 hadding-green header-no-border paragraph--type--text-with-image paragraph--view-mode--default" style="background-color:#ffffff"> <div class="container center"> <div class="text-wrapper"> <h2>Choose from</h2> <div class="box-section"> <div class="box-section-row"> <div class="box-column"> <div class="batch-label"><img loading="lazy" decoding="async" style="height: auto; max-width: 100%; width: 80px;" src="https://www.reactionbiology.com/wp-content/uploads/2023/07/gold-standard.png?width=80&height=16&name=badge(1).png" sizes="(max-width: 174px) 100vw, 80px" srcset="https://www.reactionbiology.com/wp-content/uploads/2023/07/gold-standard.png?width=137&height=27&name=badge(1).png 137w, https://www.reactionbiology.com/wp-content/uploads/2023/07/gold-standard.png?width=174&height=34&name=badge(1).png 80w, https://www.reactionbiology.com/wp-content/uploads/2023/07/gold-standard.png?width=411&height=80&name=badge(1).png 411w, https://www.reactionbiology.com/wp-content/uploads/2023/07/gold-standard.png?width=548&height=106&name=badge(1).png 548w, https://www.reactionbiology.com/wp-content/uploads/2023/07/gold-standard.png?width=685&height=133&name=badge(1).png 685w, https://www.reactionbiology.com/wp-content/uploads/2023/07/gold-standard.png?width=822&height=159&name=badge(1).png 822w" alt="badge(1)" width="80" height="16" /></div> <p><img loading="lazy" decoding="async" style="height: auto; max-width: 100%; width: 318px;" src="https://landing.reactionbiology.com/hs-fs/hubfs/section-one-bg(1).png?width=318&height=318&name=NanoBRET%20assay.png" sizes="(max-width: 318px) 100vw, 318px" srcset="https://landing.reactionbiology.com/hs-fs/hubfs/section-one-bg(1).png?width=159&height=159&name=NanoBRET%20assay.png 159w, https://landing.reactionbiology.com/hs-fs/hubfs/section-one-bg(1).png?width=318&height=318&name=NanoBRET%20assay.png 318w, https://landing.reactionbiology.com/hs-fs/hubfs/section-one-bg(1).png?width=477&height=477&name=NanoBRET%20assay.png 477w, https://landing.reactionbiology.com/hs-fs/hubfs/section-one-bg(1).png?width=636&height=636&name=NanoBRET%20assay.png 636w, https://landing.reactionbiology.com/hs-fs/hubfs/section-one-bg(1).png?width=795&height=795&name=NanoBRET%20assay.png 795w, https://landing.reactionbiology.com/hs-fs/hubfs/section-one-bg(1).png?width=954&height=954&name=NanoBRET%20assay.png 954w" alt="NanoBRET assay" width="318" height="318" /></div> <div class="box-column"> <h3>HotSpot™<br />Kinase Screen</h3> <p>Our best-in-class radiometric activity assay is now available at physiological ATP concentrations (1mM) to help you get a true-to-life insight into kinase activity.</p> <p><a class="btn green" href="https://landing.reactionbiology.com/hotspot-kinase-screening?_gl=1*11k2yz*_ga*MTMwNjM4MjAxMS4xNzA4MDA5OTE0*_ga_CB5V5J2CZL*MTcxNjk5NDYzMy4xLjAuMTcxNjk5NDYzMy4wLjAuMA&hsLang=en" target="_blank" rel="noopener">Learn more</a></p> </div> </div> <div class="box-section-row"> <div class="box-column"> <div class="batch-label"><img loading="lazy" decoding="async" style="height: auto; max-width: 100%; width: 174px;" src="https://www.reactionbiology.com/wp-content/uploads/2023/07/ideal-screens.png?width=174&height=34&name=badge(1).png" sizes="(max-width: 174px) 100vw, 174px" srcset="https://www.reactionbiology.com/wp-content/uploads/2023/07/ideal-screens.png?width=137&height=27&name=badge(1).png 137w, https://www.reactionbiology.com/wp-content/uploads/2023/07/ideal-screens.png?width=174&height=34&name=badge(1).png 174w, https://www.reactionbiology.com/wp-content/uploads/2023/07/ideal-screens.png?width=411&height=80&name=badge(1).png 411w, https://www.reactionbiology.com/wp-content/uploads/2023/07/ideal-screens.png?width=548&height=106&name=badge(1).png 548w, https://www.reactionbiology.com/wp-content/uploads/2023/07/ideal-screens.png?width=685&height=133&name=badge(1).png 685w, https://www.reactionbiology.com/wp-content/uploads/2023/07/ideal-screens.png?width=822&height=159&name=badge(1).png 822w" alt="badge(1)" width="174" height="34" /></div> <p><img loading="lazy" decoding="async" style="height: auto; max-width: 100%; width: 318px;" src="https://landing.reactionbiology.com/hs-fs/hubfs/adp-glo-thumb1.png/hs-fs/hubfs/Cellular%20Phosphorylation%20Assay.png?width=318&height=318&name=Cellular%20Phosphorylation%20Assay.png" sizes="(max-width: 318px) 100vw, 318px" srcset="https://landing.reactionbiology.com/hs-fs/hubfs/adp-glo-thumb1.png?width=159&height=159&name=Cellular%20Phosphorylation%20Assay.png 159w, https://landing.reactionbiology.com/hs-fs/hubfs/adp-glo-thumb1.png?width=318&height=318&name=Cellular%20Phosphorylation%20Assay.png 318w, https://landing.reactionbiology.com/hs-fs/hubfs/adp-glo-thumb1.png?width=477&height=477&name=Cellular%20Phosphorylation%20Assay.png 477w, https://landing.reactionbiology.com/hs-fs/hubfs/adp-glo-thumb1.png?width=636&height=636&name=Cellular%20Phosphorylation%20Assay.png 636w, https://landing.reactionbiology.com/hs-fs/hubfs/adp-glo-thumb1.png?width=795&height=795&name=Cellular%20Phosphorylation%20Assay.png 795w, https://landing.reactionbiology.com/hs-fs/hubfs/adp-glo-thumb1.png?width=954&height=954&name=Cellular%20Phosphorylation%20Assay.png 954w" alt="ADP-Glo™ Kinase Assay" width="318" height="318" /></div> <div class="box-column"> <h3>ADP-Glo™<br />Kinase Assay</h3> <p>The latest addition to our family of kinase discovery services. Ideal for introductory screens or to validate internal data.</p> <p><a class="btn green" href="https://landing.reactionbiology.com/services/adp-glo" target="_blank" rel="noopener">Learn more</a></p> </div> </div> </div> <p style="margin-top:30px;"><a class="btn green" href="https://www.reactionbiology.com/choosing-the-right-assay-for-your-kinase-drug-discovery/" target="_blank" rel="noopener">Help me select an assay</a></p> </div> </div> </div> <div id="SecId_4" class="paragraph hadding-green header-no-border paragraph--type--text-with-image paragraph--view-mode--default" style="background-color:#ffffff"> <div class="container center"> <div class="text-wrapper"> <h2 id="Deciphermechanismactivity">Decipher Your Compound’s Mechanism of Action</h2> <h4>Investigate binding kinetics of your selected inhibitor(s)</h4> <p>Our service utilizes structure-activity relationship (SAR) analysis with IC50 potency assays to elucidate the mechanism of action (MoA) of your shortlisted kinase inhibitors. This approach systematically evaluates the impact of structural modifications on inhibitor potency (IC50) against:</p> </div> </div> </div> <div id="SecId_5" class="paragraph pt2 pb5 paragraph--type--text-with-image paragraph--view-mode--default" style="background-color:#ffffff"> <div class="container center"> <div class="text-wrapper"> <div class="left-image-column-row"> <div class="row-col"><img loading="lazy" decoding="async" style="height: auto; max-width: 100%; width: 800px;" src="https://www.reactionbiology.com/wp-content/uploads/2023/07/mechanism-of-action.png?width=800&height=800&name=image2(1).png" sizes="(max-width: 800px) 100vw, 800px" srcset="https://www.reactionbiology.com/wp-content/uploads/2023/07/mechanism-of-action.png?width=400&height=400&name=image2(1).png 400w, https://www.reactionbiology.com/wp-content/uploads/2023/07/mechanism-of-action.png?width=800&height=800&name=image2(1).png 800w, https://www.reactionbiology.com/wp-content/uploads/2023/07/mechanism-of-action.png?width=1200&height=1200&name=image2(1).png 1200w, https://www.reactionbiology.com/wp-content/uploads/2023/07/mechanism-of-action.png?width=1600&height=1600&name=image2(1).png 1600w, https://www.reactionbiology.com/wp-content/uploads/2023/07/mechanism-of-action.png?width=2000&height=2000&name=image2(1).png 2000w, https://www.reactionbiology.com/wp-content/uploads/2023/07/mechanism-of-action.png?width=2400&height=2400&name=image2(1).png 2400w" alt="image2(1)" width="800" height="800" /></div> <div class="row-col"> <ul> <li><strong>Wild-type target kinase:</strong> The unmodified form of the target kinase</li> <li><strong>Kinase variants harboring mutations:</strong> These variants contain targeted modifications in key kinase domains</li> </ul> <p>By meticulously comparing IC50 values across these variants, you gain invaluable insights into the critical binding interactions between the inhibitor and the kinase. We help identify three key interaction types:</p> <ul> <li><strong>Covalent inhibitor:</strong> Forms a direct chemical bond with the kinase.</li> <li><strong>ATP-competitive:</strong> Competes with ATP for binding to the ATP-binding pocket.</li> <li><strong>Substrate-competitive:</strong> Competes with the substrate for binding to the substrate-binding pocket.</li> </ul> <p>This refined approach not only confirms your initial kinase activity profiling findings but also provides a deeper mechanistic understanding, paving the way for targeted optimization strategies.</p> <p><a class="btn green" href="https://www.reactionbiology.com/contact/contact-us/" target="_blank" rel="noopener">Design your study</a></p> </div> </div> </div> </div> </div> <div id="SecId_6" class="paragraph pb5 hadding-green header-no-border paragraph--type--text-with-image paragraph--view-mode--default" style="background-color:#f7f7f7"> <div class="container center"> <div class="text-wrapper"> <h2 id="Kinaseselectivityprofiling">Kinase Selectivity Profiling</h2> <h4>Explore selectivity and off-target effects of your compounds across the human kinome</h4> <div class="left-image-column-row"> <div class="row-col"><img loading="lazy" decoding="async" style="height: auto; max-width: 100%; width: 800px;" src="https://www.reactionbiology.com/wp-content/uploads/2023/07/kinase-selectivity-profiling-v2.png?width=800&height=800&name=Kinase%20selectivity%20profiling.png" sizes="(max-width: 800px) 100vw, 800px" srcset="https://www.reactionbiology.com/wp-content/uploads/2023/07/kinase-selectivity-profiling-v2.png?width=400&height=400&name=Kinase%20selectivity%20profiling.png 400w, https://www.reactionbiology.com/wp-content/uploads/2023/07/kinase-selectivity-profiling-v2.png?width=800&height=800&name=Kinase%20selectivity%20profiling.png 800w, https://www.reactionbiology.com/wp-content/uploads/2023/07/kinase-selectivity-profiling-v2.png?width=1200&height=1200&name=Kinase%20selectivity%20profiling.png 1200w, https://www.reactionbiology.com/wp-content/uploads/2023/07/kinase-selectivity-profiling-v2.png?width=1600&height=1600&name=Kinase%20selectivity%20profiling.png 1600w, https://www.reactionbiology.com/wp-content/uploads/2023/07/kinase-selectivity-profiling-v2.png?width=2000&height=2000&name=Kinase%20selectivity%20profiling.png 2000w, https://www.reactionbiology.com/wp-content/uploads/2023/07/kinase-selectivity-profiling-v2.png?width=2400&height=2400&name=Kinase%20selectivity%20profiling.png 2400w" alt="Kinase selectivity profiling" width="800" height="800" /></div> <div class="row-col"> <p>We offer the industry’s largest collection of the human kinome with more than 700+ kinases. Our flexible approach allows you to preselect a subfamily of kinases or the entire human kinome.</p> <p>Benefits of Kinase Selectivity Profiling:</p> <ul> <li><strong>Early Detection of Off-Target Effects:</strong> Proactive identification of drug selectivity and potential liabilities minimizes risk and saves resources during development.</li> <li><strong>Unveiling New Kinase Opportunities:</strong> This analysis can reveal unexpected sensitivities towards other kinases within your target pathway, potentially leading to the discovery of novel therapeutic targets.</li> </ul> <p><a class="btn green" href="https://www.reactionbiology.com/services/kinase-assays/kinase-panel-screening/#kps-id2" target="_blank" rel="noopener">Access panel</a></p> </div> </div> </div> </div> </div> <div id="SecId_7" class="paragraph two_columns pb5 hadding-green header-no-border paragraph--type--text-with-image paragraph--view-mode--default" style="background-color:#ffffff"> <div class="container center"> <div class="text-wrapper"> <h2 id="TargetEngagement">Target Engagement and Functionality inside Living Cells</h2> <h4>Evaluate the selectivity of your kinase inhibitor with advanced functional assays</h4> <p>Traditional <em>in vitro</em> assays only tell part of the story. Our target engagement and phosphorylation assay portfolio provides fundamental insights into how your drug interacts with its target and affects signalling pathways inside a living cell</p> <div class="box-section"> <div class="box-section-row"> <div class="box-column"><img loading="lazy" decoding="async" style="height: auto; max-width: 100%; width: 318px;" src="https://www.reactionbiology.com/wp-content/uploads/2023/07/nanobret-1.png?width=318&height=318&name=NanoBRET%20assay.png" sizes="(max-width: 318px) 100vw, 318px" srcset="https://www.reactionbiology.com/wp-content/uploads/2023/07/nanobret-1.png?width=159&height=159&name=NanoBRET%20assay.png 159w, https://www.reactionbiology.com/wp-content/uploads/2023/07/nanobret-1.png?width=318&height=318&name=NanoBRET%20assay.png 318w, https://www.reactionbiology.com/wp-content/uploads/2023/07/nanobret-1.png?width=477&height=477&name=NanoBRET%20assay.png 477w, https://www.reactionbiology.com/wp-content/uploads/2023/07/nanobret-1.png?width=636&height=636&name=NanoBRET%20assay.png 636w, https://landing.reactionbiology.com/hs-fs/hubfs/NanoBRET%20assay.png?width=795&height=795&name=NanoBRET%20assay.png 795w, https://www.reactionbiology.com/wp-content/uploads/2023/07/nanobret-1.png?width=954&height=954&name=NanoBRET%20assay.png 954w" alt="NanoBRET assay" width="318" height="318" /></div> <div class="box-column"> <h3>NanoBRET Assay</h3> <p>Measure the apparent affinity of your test compound(s) for its target within intact living cells</p> <p><a class="btn green" href="https://www.reactionbiology.com/services/kinase-assays/nanobret-intracellular-kinase-assay/?utm_term=nanobret%20assay&utm_campaign=Cell+Line+Profiling&utm_source=adwords&utm_medium=ppc&hsa_acc=9987075109&hsa_cam=126356784&hsa_grp=55733196183&hsa_ad=628292302014&hsa_src=g&hsa_tgt=kwd-469192287507&hsa_kw=nanobret%20assay&hsa_mt=b&hsa_net=adwords&hsa_ver=3&gclid=Cj0KCQjwpNuyBhCuARIsANJqL9NnveCs43WiRFexBZ9sjZVuNtFwSlaUMITh_wKf6NdGuJGK4sE8tHkaAjP_EALw_wcB" target="_blank" rel="noopener">Learn more</a></p> </div> </div> <div class="box-section-row"> <div class="box-column"><img loading="lazy" decoding="async" style="height: auto; max-width: 100%; width: 318px;" src="https://landing.reactionbiology.com/hs-fs/hubfs/Cellular%20Phosphorylation%20Assay.png?width=318&height=318&name=Cellular%20Phosphorylation%20Assay.png" sizes="(max-width: 318px) 100vw, 318px" srcset="https://landing.reactionbiology.com/hs-fs/hubfs/Cellular%20Phosphorylation%20Assay.png?width=159&height=159&name=Cellular%20Phosphorylation%20Assay.png 159w, https://landing.reactionbiology.com/hs-fs/hubfs/Cellular%20Phosphorylation%20Assay.png?width=318&height=318&name=Cellular%20Phosphorylation%20Assay.png 318w, https://landing.reactionbiology.com/hs-fs/hubfs/Cellular%20Phosphorylation%20Assay.png?width=477&height=477&name=Cellular%20Phosphorylation%20Assay.png 477w, https://landing.reactionbiology.com/hs-fs/hubfs/Cellular%20Phosphorylation%20Assay.png?width=636&height=636&name=Cellular%20Phosphorylation%20Assay.png 636w, https://landing.reactionbiology.com/hs-fs/hubfs/Cellular%20Phosphorylation%20Assay.png?width=795&height=795&name=Cellular%20Phosphorylation%20Assay.png 795w, https://landing.reactionbiology.com/hs-fs/hubfs/Cellular%20Phosphorylation%20Assay.png?width=954&height=954&name=Cellular%20Phosphorylation%20Assay.png 954w" alt="Cellular Phosphorylation Assay" width="318" height="318" /></div> <div class="box-column"> <h3>Cellular Phosphorylation Assay</h3> <p>Evaluate the impact of your test compound on downstream phosphorylation targets</p> <p><a class="btn green" href="https://www.reactionbiology.com/services/kinase-assays/cellular-phosphorylation-assay/" target="_blank" rel="noopener">Know more</a></p> </div> </div> </div> <div class="box-section"> <div class="box-section-row"> <div class="box-column"><img loading="lazy" decoding="async" style="height: auto; max-width: 100%; width: 318px;" src="https://www.reactionbiology.com/wp-content/uploads/2023/07/cell-dividing.png?width=318&height=318&name=NanoBRET%20assay.png" sizes="(max-width: 318px) 100vw, 318px" srcset="https://www.reactionbiology.com/wp-content/uploads/2023/07/cell-dividing.png?width=159&height=159&name=NanoBRET%20assay.png 159w, https://www.reactionbiology.com/wp-content/uploads/2023/07/cell-dividing.png?width=318&height=318&name=NanoBRET%20assay.png 318w, https://www.reactionbiology.com/wp-content/uploads/2023/07/cell-dividing.png?width=477&height=477&name=NanoBRET%20assay.png 477w, https://www.reactionbiology.com/wp-content/uploads/2023/07/cell-dividing.png?width=636&height=636&name=NanoBRET%20assay.png 636w, https://www.reactionbiology.com/wp-content/uploads/2023/07/cell-dividing.png?width=795&height=795&name=NanoBRET%20assay.png 795w, https://www.reactionbiology.com/wp-content/uploads/2023/07/cell-dividing.png?width=954&height=954&name=NanoBRET%20assay.png 954w" alt="NanoBRET assay" width="318" height="318" /></div> <div class="box-column"> <h3>BaF3 Cell Proliferation Assay</h3> <p>Investigate your Kinase Inhibitor activity in a controlled settings</p> <p><a class="btn green" href="https://www.reactionbiology.com/services/kinase-assays/baf3-cell-proliferation-assay/" target="_blank" rel="noopener">Learn more</a></p> </div> </div> </div> </div> </div> </div> <div id="SecId_8" class="paragraph full_width_column pb5 hadding-green header-no-border paragraph--type--text-with-image paragraph--view-mode--default" style="background-color:#f7f7f7"> <div class="container center"> <div class="text-wrapper"> <h2 id="Preclinicaltesting">Preclinical Testing</h2> <h4>Test the <em>in vitro</em> and <em>in vivo</em> efficacy and safety of your compound</h4> <p>Our diverse cell lines (2D & 3D) and advanced in vivo models offer an in-depth view of your kinase inhibitor’s efficacy, safety, and potential on specific indications or a broader cancer panel. Navigate development with confidence.</p> <div class="box-section"> <div class="box-section-row"> <div class="box-column"><img loading="lazy" decoding="async" style="height: auto; max-width: 100%; width: 318px;" src="https://landing.reactionbiology.com/hs-fs/hubfs/ProLiFiler.png?width=318&height=318&name=ProLiFiler.png" sizes="(max-width: 318px) 100vw, 318px" srcset="https://landing.reactionbiology.com/hs-fs/hubfs/ProLiFiler.png?width=159&height=159&name=ProLiFiler.png 159w, https://landing.reactionbiology.com/hs-fs/hubfs/ProLiFiler.png?width=318&height=318&name=ProLiFiler.png 318w, https://landing.reactionbiology.com/hs-fs/hubfs/ProLiFiler.png?width=477&height=477&name=ProLiFiler.png 477w, https://landing.reactionbiology.com/hs-fs/hubfs/ProLiFiler.png?width=636&height=636&name=ProLiFiler.png 636w, https://landing.reactionbiology.com/hs-fs/hubfs/ProLiFiler.png?width=795&height=795&name=ProLiFiler.png 795w, https://landing.reactionbiology.com/hs-fs/hubfs/ProLiFiler.png?width=954&height=954&name=ProLiFiler.png 954w" alt="ProLiFiler" width="318" height="318" /></div> <div class="box-column"> <h3>ProLiFiler™</h3> <p>Fast-track your lead identification with a powerful efficacy screen across 160 cancer cell lines. Pinpoint optimal targets, predict drug response, and select the best candidates for development.</p> <p><a class="btn green" href="https://www.reactionbiology.com/services/cell-based-assays/prolifiler-cell-line-panel-screening" target="_blank" rel="noopener">Learn more</a></p> </div> </div> </div> <div class="box-section"> <div class="box-section-row"> <div class="box-column"><img loading="lazy" decoding="async" style="height: auto; max-width: 100%; width: 318px;" src="https://www.reactionbiology.com/wp-content/uploads/2023/07/In-vivo-efficacy-screen-2.png?width=318&height=318&name=In%20vivo%20efficacy%20screen.png" sizes="(max-width: 318px) 100vw, 318px" srcset="https://www.reactionbiology.com/wp-content/uploads/2023/07/In-vivo-efficacy-screen-2.png?width=159&height=159&name=In%20vivo%20efficacy%20screen.png 159w, https://www.reactionbiology.com/wp-content/uploads/2023/07/In-vivo-efficacy-screen-2.png?width=318&height=318&name=In%20vivo%20efficacy%20screen.png 318w, https://www.reactionbiology.com/wp-content/uploads/2023/07/In-vivo-efficacy-screen-2.png?width=477&height=477&name=In%20vivo%20efficacy%20screen.png 477w, https://www.reactionbiology.com/wp-content/uploads/2023/07/In-vivo-efficacy-screen-2.png?width=636&height=636&name=In%20vivo%20efficacy%20screen.png 636w, https://www.reactionbiology.com/wp-content/uploads/2023/07/In-vivo-efficacy-screen-2.png?width=795&height=795&name=In%20vivo%20efficacy%20screen.png 795w, https://www.reactionbiology.com/wp-content/uploads/2023/07/In-vivo-efficacy-screen-2.png?width=954&height=954&name=In%20vivo%20efficacy%20screen.png 954w" alt="In vivo efficacy screen" width="318" height="318" /></div> <div class="box-column"> <h3><em>In Vitro</em> Toxicology</h3> <p>Leverage our InVest functional and biochemical assays to assess the safety of your lead compound(s)</p> <p><a class="btn green" href="https://www.reactionbiology.com/services/adme-safety/in-vitro-safety-screening/" target="_blank" rel="noopener">Learn more</a></p> </div> </div> </div> <div class="box-section"> <div class="box-section-row"> <div class="box-column"><img loading="lazy" decoding="async" style="height: auto; 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