Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes

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data-component-authors-activator="authors-list"><li class="c-article-author-list__item"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Sebastian-Amigorena-Aff1" data-author-popup="auth-Sebastian-Amigorena-Aff1" data-author-search="Amigorena, Sebastian">Sebastian Amigorena</a><sup class="u-js-hide"><a href="#Aff1">1</a></sup>, </li><li class="c-article-author-list__item"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-James_R_-Drake-Aff1" data-author-popup="auth-James_R_-Drake-Aff1" data-author-search="Drake, James R.">James R. Drake</a><sup class="u-js-hide"><a href="#Aff1">1</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Paul-Webster-Aff1" data-author-popup="auth-Paul-Webster-Aff1" data-author-search="Webster, Paul">Paul Webster</a><sup class="u-js-hide"><a href="#Aff1">1</a></sup> & </li><li class="c-article-author-list__show-more" aria-label="Show all 4 authors for this article" title="Show all 4 authors for this article">…</li><li class="c-article-author-list__item"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Ira-Mellman-Aff1" data-author-popup="auth-Ira-Mellman-Aff1" data-author-search="Mellman, Ira">Ira Mellman</a><sup class="u-js-hide"><a href="#Aff1">1</a></sup> </li></ul><button aria-expanded="false" class="c-article-author-list__button"><svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-chevron-down-medium"></use></svg><span>Show authors</span></button> <p class="c-article-info-details" data-container-section="info"> <a data-test="journal-link" href="/" data-track="click" data-track-action="journal homepage" data-track-category="article body" data-track-label="link"><i data-test="journal-title">Nature</i></a> <b data-test="journal-volume"><span class="u-visually-hidden">volume</span> 369</b>, <span class="u-visually-hidden">pages </span>113–120 (<span data-test="article-publication-year">1994</span>)<a href="#citeas" class="c-article-info-details__cite-as u-hide-print" data-track="click" data-track-action="cite this article" data-track-label="link">Cite this article</a> </p> <div class="c-article-metrics-bar__wrapper u-clear-both"> <ul class="c-article-metrics-bar u-list-reset"> <li class=" c-article-metrics-bar__item" data-test="access-count"> <p class="c-article-metrics-bar__count">579 <span class="c-article-metrics-bar__label">Accesses</span></p> </li> <li class="c-article-metrics-bar__item" data-test="citation-count"> <p class="c-article-metrics-bar__count">424 <span class="c-article-metrics-bar__label">Citations</span></p> </li> <li class="c-article-metrics-bar__item" data-test="altmetric-score"> <p class="c-article-metrics-bar__count">12 <span class="c-article-metrics-bar__label">Altmetric</span></p> </li> <li class="c-article-metrics-bar__item"> <p class="c-article-metrics-bar__details"><a href="/articles/369113a0/metrics" data-track="click" data-track-action="view metrics" data-track-label="link" rel="nofollow">Metrics <span class="u-visually-hidden">details</span></a></p> </li> </ul> </div> </header> </div> <div class="c-article-body"> <section aria-labelledby="Abs1" data-title="Abstract" lang="en"><div class="c-article-section" id="Abs1-section"><h2 class="c-article-section__title js-section-title js-c-reading-companion-sections-item" id="Abs1">Abstract</h2><div class="c-article-section__content" id="Abs1-content"><p> Endocytosis of antigen by antigen-presenting cells results in the production of peptides that bind to newly synthesized class II molecules of the major histocompatibility complex. A new population of class II-enriched vesicles has been discovered in B lymphocytes that accumulate internalized antigen but are distinct from endosomes and lysosomes. These vesicles also transiently accumulate newly synthesized class II and class II-peptide complexes and appear to be a compartment specialized for the transport and loading of class II molecules.</p></div></div></section> <noscript> <div class="c-nature-box c-nature-box--side " data-component="entitlement-box"> <div class="js-access-button"> <a href="https://wayf.springernature.com?redirect_uri=https%3A%2F%2Fwww.nature.com%2Farticles%2F369113a0" class="c-article__button" data-test="ra21"> <svg class="u-icon" width="18" height="18" aria-hidden="true" focusable="false"><use href="#icon-institution"></use></svg> <span class="c-article__button-text">Access through your institution</span> </a> </div> <div class="js-buy-button"> <a href="#access-options" class="c-article__button c-article__button--inverted" data-test="ra21"> <span>Buy or subscribe</span> </a> </div> </div> </noscript> <div class="js-context-bar-sticky-point-mobile" data-track-context="article body"> </div> <div 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js-c-reading-companion-references-item" data-counter="1"><p class="c-article-references__text" id="ref-CR1">Roche, P. A., Marks, M. S. & Cresswell, P. <i>Nature</i> <b>354</b>, 392–394 (1991).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1038/354392a0" data-track-item_id="10.1038/354392a0" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1038%2F354392a0" aria-label="Article reference 1" data-doi="10.1038/354392a0">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="ads reference" data-track-action="ads reference" href="http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1991Natur.354..392R" aria-label="ADS reference 1">ADS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaK38XhvFCgsA%3D%3D" aria-label="CAS reference 1">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=1956401" aria-label="PubMed reference 1">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 1" href="http://scholar.google.com/scholar_lookup?&title=&journal=Nature&doi=10.1038%2F354392a0&volume=354&pages=392-394&publication_year=1991&author=Roche%2CPA&author=Marks%2CMS&author=Cresswell%2CP"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="2"><p class="c-article-references__text" id="ref-CR2">Germain, R. N. & Margoulies, D. H. <i>A. Rev. Immun.</i> <b>11</b>, 403–450 (1993).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1146/annurev.iy.11.040193.002155" data-track-item_id="10.1146/annurev.iy.11.040193.002155" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1146%2Fannurev.iy.11.040193.002155" aria-label="Article reference 2" data-doi="10.1146/annurev.iy.11.040193.002155">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaK3sXktVKlsrw%3D" aria-label="CAS reference 2">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 2" href="http://scholar.google.com/scholar_lookup?&title=&journal=A.%20Rev.%20Immun.&doi=10.1146%2Fannurev.iy.11.040193.002155&volume=11&pages=403-450&publication_year=1993&author=Germain%2CRN&author=Margoulies%2CDH"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="3"><p class="c-article-references__text" id="ref-CR3">Hunt, D. F. <i>et al.</i> <i>Science</i> <b>256</b>, 1817–1820 (1992).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1126/science.1319610" data-track-item_id="10.1126/science.1319610" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1126%2Fscience.1319610" aria-label="Article reference 3" data-doi="10.1126/science.1319610">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="ads reference" data-track-action="ads reference" href="http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1992Sci...256.1817H" aria-label="ADS reference 3">ADS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaK38XltV2ltLg%3D" aria-label="CAS reference 3">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=1319610" aria-label="PubMed reference 3">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 3" href="http://scholar.google.com/scholar_lookup?&title=&journal=Science&doi=10.1126%2Fscience.1319610&volume=256&pages=1817-1820&publication_year=1992&author=Hunt%2CDF"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="4"><p class="c-article-references__text" id="ref-CR4">Chicz, R. M. <i>et al.</i> <i>J. exp. Med.</i> <b>178</b>, 27–47 (1993).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1084/jem.178.1.27" data-track-item_id="10.1084/jem.178.1.27" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1084%2Fjem.178.1.27" aria-label="Article reference 4" data-doi="10.1084/jem.178.1.27">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaK3sXltFGjs7o%3D" aria-label="CAS reference 4">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8315383" aria-label="PubMed reference 4">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 4" href="http://scholar.google.com/scholar_lookup?&title=&journal=J.%20exp.%20Med.&doi=10.1084%2Fjem.178.1.27&volume=178&pages=27-47&publication_year=1993&author=Chicz%2CRM"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="5"><p class="c-article-references__text" id="ref-CR5">Rudensky, A., Preston, H. P., Hong, S. C., Barlow, A. & Janeway, C. J. <i>Nature</i> <b>353</b>, 622–627 (1991).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1038/353622a0" data-track-item_id="10.1038/353622a0" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1038%2F353622a0" aria-label="Article reference 5" data-doi="10.1038/353622a0">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="ads reference" data-track-action="ads reference" href="http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1991Natur.353..622R" aria-label="ADS reference 5">ADS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaK38XkvVSm" aria-label="CAS reference 5">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=1656276" aria-label="PubMed reference 5">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 5" href="http://scholar.google.com/scholar_lookup?&title=&journal=Nature&doi=10.1038%2F353622a0&volume=353&pages=622-627&publication_year=1991&author=Rudensky%2CA&author=Preston%2CHP&author=Hong%2CSC&author=Barlow%2CA&author=Janeway%2CCJ"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="6"><p class="c-article-references__text" id="ref-CR6">Davidson, H. W., Reid, P. A., Lanzavecchia, A. & Watts, C. <i>Cell</i> <b>67</b>, 105–116 (1991).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/0092-8674(91)90575-J" data-track-item_id="10.1016/0092-8674(91)90575-J" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2F0092-8674%2891%2990575-J" aria-label="Article reference 6" data-doi="10.1016/0092-8674(91)90575-J">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaK3MXmt12qt7Y%3D" aria-label="CAS reference 6">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=1913812" aria-label="PubMed reference 6">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 6" href="http://scholar.google.com/scholar_lookup?&title=&journal=Cell&doi=10.1016%2F0092-8674%2891%2990575-J&volume=67&pages=105-116&publication_year=1991&author=Davidson%2CHW&author=Reid%2CPA&author=Lanzavecchia%2CA&author=Watts%2CC"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="7"><p class="c-article-references__text" id="ref-CR7">Neefjes, J. J., Stollorz, V., Peters, P. J., Geuze, H. J. & Ploegh, H. L. <i>Cell</i> <b>61</b>, 171–183 (1990).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/0092-8674(90)90224-3" data-track-item_id="10.1016/0092-8674(90)90224-3" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2F0092-8674%2890%2990224-3" aria-label="Article reference 7" data-doi="10.1016/0092-8674(90)90224-3">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaK3cXitlelsbg%3D" aria-label="CAS reference 7">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2156628" aria-label="PubMed reference 7">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 7" href="http://scholar.google.com/scholar_lookup?&title=&journal=Cell&doi=10.1016%2F0092-8674%2890%2990224-3&volume=61&pages=171-183&publication_year=1990&author=Neefjes%2CJJ&author=Stollorz%2CV&author=Peters%2CPJ&author=Geuze%2CHJ&author=Ploegh%2CHL"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="8"><p class="c-article-references__text" id="ref-CR8">Neefjes, J. J. & Ploegh, H. L. <i>EMBO J.</i> <b>11</b>, 411–416 (1992).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1002/j.1460-2075.1992.tb05069.x" data-track-item_id="10.1002/j.1460-2075.1992.tb05069.x" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1002%2Fj.1460-2075.1992.tb05069.x" aria-label="Article reference 8" data-doi="10.1002/j.1460-2075.1992.tb05069.x">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaK38XhsV2ltL4%3D" aria-label="CAS reference 8">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=1311249" aria-label="PubMed reference 8">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC556469" aria-label="PubMed Central reference 8">PubMed Central</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 8" href="http://scholar.google.com/scholar_lookup?&title=&journal=EMBO%20J.&doi=10.1002%2Fj.1460-2075.1992.tb05069.x&volume=11&pages=411-416&publication_year=1992&author=Neefjes%2CJJ&author=Ploegh%2CHL"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="9"><p class="c-article-references__text" id="ref-CR9">Lotteau, V. <i>et al.</i> <i>Nature</i> <b>348</b>, 600–605 (1990).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1038/348600a0" data-track-item_id="10.1038/348600a0" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1038%2F348600a0" aria-label="Article reference 9" data-doi="10.1038/348600a0">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="ads reference" data-track-action="ads reference" href="http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1990Natur.348..600L" aria-label="ADS reference 9">ADS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaK3MXmtVWjsA%3D%3D" aria-label="CAS reference 9">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2250716" aria-label="PubMed reference 9">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 9" href="http://scholar.google.com/scholar_lookup?&title=&journal=Nature&doi=10.1038%2F348600a0&volume=348&pages=600-605&publication_year=1990&author=Lotteau%2CV"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="10"><p class="c-article-references__text" id="ref-CR10">Blake, O. & Dobberstein, B. <i>Cell</i> <b>63</b>, 707–716 (1990).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/0092-8674(90)90137-4" data-track-item_id="10.1016/0092-8674(90)90137-4" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2F0092-8674%2890%2990137-4" aria-label="Article reference 10" data-doi="10.1016/0092-8674(90)90137-4">Article</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 10" href="http://scholar.google.com/scholar_lookup?&title=&journal=Cell&doi=10.1016%2F0092-8674%2890%2990137-4&volume=63&pages=707-716&publication_year=1990&author=Blake%2CO&author=Dobberstein%2CB"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="11"><p class="c-article-references__text" id="ref-CR11">Peters, P. J., Neefjes, J. J., Oorschot, V., Ploegh, H. L. & Geuze, H. J. <i>Nature</i> <b>349</b>, 669–676 (1991).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1038/349669a0" data-track-item_id="10.1038/349669a0" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1038%2F349669a0" aria-label="Article reference 11" data-doi="10.1038/349669a0">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="ads reference" data-track-action="ads reference" href="http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1991Natur.349..669P" aria-label="ADS reference 11">ADS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaK3MXhsVWisrw%3D" aria-label="CAS reference 11">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=1847504" aria-label="PubMed reference 11">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 11" href="http://scholar.google.com/scholar_lookup?&title=&journal=Nature&doi=10.1038%2F349669a0&volume=349&pages=669-676&publication_year=1991&author=Peters%2CPJ&author=Neefjes%2CJJ&author=Oorschot%2CV&author=Ploegh%2CHL&author=Geuze%2CHJ"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="12"><p class="c-article-references__text" id="ref-CR12">Roche, P. A. & Cresswell, P. <i>Proc. natn. Acad. Sci. USA</i> <b>88</b>, 3150–3154 (1991).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1073/pnas.88.8.3150" data-track-item_id="10.1073/pnas.88.8.3150" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1073%2Fpnas.88.8.3150" aria-label="Article reference 12" data-doi="10.1073/pnas.88.8.3150">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="ads reference" data-track-action="ads reference" href="http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1991PNAS...88.3150R" aria-label="ADS reference 12">ADS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaK3MXktVKmu74%3D" aria-label="CAS reference 12">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 12" href="http://scholar.google.com/scholar_lookup?&title=&journal=Proc.%20natn.%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.88.8.3150&volume=88&pages=3150-3154&publication_year=1991&author=Roche%2CPA&author=Cresswell%2CP"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="13"><p class="c-article-references__text" id="ref-CR13">Teyton, L. <i>et al.</i> <i>Nature</i> <b>348</b>, 39–44 (1990).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1038/348039a0" data-track-item_id="10.1038/348039a0" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1038%2F348039a0" aria-label="Article reference 13" data-doi="10.1038/348039a0">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="ads reference" data-track-action="ads reference" href="http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1990Natur.348...39T" aria-label="ADS reference 13">ADS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaK3cXmt12it7Y%3D" aria-label="CAS reference 13">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2234057" aria-label="PubMed reference 13">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 13" href="http://scholar.google.com/scholar_lookup?&title=&journal=Nature&doi=10.1038%2F348039a0&volume=348&pages=39-44&publication_year=1990&author=Teyton%2CL"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="14"><p class="c-article-references__text" id="ref-CR14">Guagliardi, L. E. <i>et al.</i> <i>Nature</i> <b>343</b>, 133–139 (1990).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1038/343133a0" data-track-item_id="10.1038/343133a0" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1038%2F343133a0" aria-label="Article reference 14" data-doi="10.1038/343133a0">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="ads reference" data-track-action="ads reference" href="http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1990Natur.343..133G" aria-label="ADS reference 14">ADS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaK3cXps1GmtQ%3D%3D" aria-label="CAS reference 14">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2404209" aria-label="PubMed reference 14">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 14" href="http://scholar.google.com/scholar_lookup?&title=&journal=Nature&doi=10.1038%2F343133a0&volume=343&pages=133-139&publication_year=1990&author=Guagliardi%2CLE"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="15"><p class="c-article-references__text" id="ref-CR15">Harding, C. V., Unanue, E. R., Slot, J. W., Schwartz, A. L. & Geuze, H. J. <i>Proc. natn. Acad. Sci. U.S.A.</i> <b>87</b>, 5553–5557 (1990).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1073/pnas.87.14.5553" data-track-item_id="10.1073/pnas.87.14.5553" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1073%2Fpnas.87.14.5553" aria-label="Article reference 15" data-doi="10.1073/pnas.87.14.5553">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="ads reference" data-track-action="ads reference" href="http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1990PNAS...87.5553H" aria-label="ADS reference 15">ADS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaK3cXkvFGrsLw%3D" aria-label="CAS reference 15">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 15" href="http://scholar.google.com/scholar_lookup?&title=&journal=Proc.%20natn.%20Acad.%20Sci.%20U.S.A.&doi=10.1073%2Fpnas.87.14.5553&volume=87&pages=5553-5557&publication_year=1990&author=Harding%2CCV&author=Unanue%2CER&author=Slot%2CJW&author=Schwartz%2CAL&author=Geuze%2CHJ"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="16"><p class="c-article-references__text" id="ref-CR16">Harding, C. V., Collins, D. S., Slot, J. W., Geuze, H. J. & Unanue, E. R. <i>Cell</i> <b>64</b>, 393–401 (1991).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/0092-8674(91)90647-H" data-track-item_id="10.1016/0092-8674(91)90647-H" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2F0092-8674%2891%2990647-H" aria-label="Article reference 16" data-doi="10.1016/0092-8674(91)90647-H">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaK3MXpvFygug%3D%3D" aria-label="CAS reference 16">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=1899049" aria-label="PubMed reference 16">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 16" href="http://scholar.google.com/scholar_lookup?&title=&journal=Cell&doi=10.1016%2F0092-8674%2891%2990647-H&volume=64&pages=393-401&publication_year=1991&author=Harding%2CCV&author=Collins%2CDS&author=Slot%2CJW&author=Geuze%2CHJ&author=Unanue%2CER"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="17"><p class="c-article-references__text" id="ref-CR17">Lanzavecchia, A. <i>Nature</i> <b>314</b>, 537–539 (1985).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1038/314537a0" data-track-item_id="10.1038/314537a0" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1038%2F314537a0" aria-label="Article reference 17" data-doi="10.1038/314537a0">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="ads reference" data-track-action="ads reference" href="http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1985Natur.314..537L" aria-label="ADS reference 17">ADS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:STN:280:DyaL2M7ovVaktg%3D%3D" aria-label="CAS reference 17">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=3157869" aria-label="PubMed reference 17">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 17" href="http://scholar.google.com/scholar_lookup?&title=&journal=Nature&doi=10.1038%2F314537a0&volume=314&pages=537-539&publication_year=1985&author=Lanzavecchia%2CA"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="18"><p class="c-article-references__text" id="ref-CR18">Lanzavecchia, A. <i>A. Rev. Immun.</i> <b>8</b>, 773–793 (1990).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1146/annurev.iy.08.040190.004013" data-track-item_id="10.1146/annurev.iy.08.040190.004013" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1146%2Fannurev.iy.08.040190.004013" aria-label="Article reference 18" data-doi="10.1146/annurev.iy.08.040190.004013">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaK3cXkslGqsbw%3D" aria-label="CAS reference 18">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 18" href="http://scholar.google.com/scholar_lookup?&title=&journal=A.%20Rev.%20Immun.&doi=10.1146%2Fannurev.iy.08.040190.004013&volume=8&pages=773-793&publication_year=1990&author=Lanzavecchia%2CA"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="19"><p class="c-article-references__text" id="ref-CR19">Schmid, S. L., Fuchs, R., Male, P. & Mellman, I. <i>Cell</i> <b>52</b>, 73–83 (1988).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/0092-8674(88)90532-6" data-track-item_id="10.1016/0092-8674(88)90532-6" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2F0092-8674%2888%2990532-6" aria-label="Article reference 19" data-doi="10.1016/0092-8674(88)90532-6">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaL1cXhvVCjtbg%3D" aria-label="CAS reference 19">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=3345561" aria-label="PubMed reference 19">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 19" href="http://scholar.google.com/scholar_lookup?&title=&journal=Cell&doi=10.1016%2F0092-8674%2888%2990532-6&volume=52&pages=73-83&publication_year=1988&author=Schmid%2CSL&author=Fuchs%2CR&author=Male%2CP&author=Mellman%2CI"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="20"><p class="c-article-references__text" id="ref-CR20">Jensen, P. E. <i>J. exp. Med.</i> <b>174</b>, 1111–1120 (1991).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1084/jem.174.5.1111" data-track-item_id="10.1084/jem.174.5.1111" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1084%2Fjem.174.5.1111" aria-label="Article reference 20" data-doi="10.1084/jem.174.5.1111">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaK3MXmtVGnurc%3D" aria-label="CAS reference 20">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=1940792" aria-label="PubMed reference 20">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 20" href="http://scholar.google.com/scholar_lookup?&title=&journal=J.%20exp.%20Med.&doi=10.1084%2Fjem.174.5.1111&volume=174&pages=1111-1120&publication_year=1991&author=Jensen%2CPE"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="21"><p class="c-article-references__text" id="ref-CR21">Marsh, M. <i>et al.</i> <i>J. Cell Biol.</i> <b>104</b>, 875–886 (1987).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1083/jcb.104.4.875" data-track-item_id="10.1083/jcb.104.4.875" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1083%2Fjcb.104.4.875" aria-label="Article reference 21" data-doi="10.1083/jcb.104.4.875">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaL2sXitFSgurw%3D" aria-label="CAS reference 21">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=3031085" aria-label="PubMed reference 21">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 21" href="http://scholar.google.com/scholar_lookup?&title=&journal=J.%20Cell%20Biol.&doi=10.1083%2Fjcb.104.4.875&volume=104&pages=875-886&publication_year=1987&author=Marsh%2CM"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="22"><p class="c-article-references__text" id="ref-CR22">Amigorena, S. <i>et al.</i> <i>Science</i> <b>256</b>, 1808–1812 (1992).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1126/science.1535455" data-track-item_id="10.1126/science.1535455" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1126%2Fscience.1535455" aria-label="Article reference 22" data-doi="10.1126/science.1535455">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="ads reference" data-track-action="ads reference" href="http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1992Sci...256.1808A" aria-label="ADS reference 22">ADS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaK38XkvVyhtLY%3D" aria-label="CAS reference 22">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=1535455" aria-label="PubMed reference 22">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 22" href="http://scholar.google.com/scholar_lookup?&title=&journal=Science&doi=10.1126%2Fscience.1535455&volume=256&pages=1808-1812&publication_year=1992&author=Amigorena%2CS"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="23"><p class="c-article-references__text" id="ref-CR23">Germain, R. N. & Hendrix, L. H. <i>Nature</i> <b>353</b>, 134–139 (1991).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1038/353134a0" data-track-item_id="10.1038/353134a0" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1038%2F353134a0" aria-label="Article reference 23" data-doi="10.1038/353134a0">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="ads reference" data-track-action="ads reference" href="http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1991Natur.353..134G" aria-label="ADS reference 23">ADS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaK3MXmsFelt74%3D" aria-label="CAS reference 23">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=1891045" aria-label="PubMed reference 23">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 23" href="http://scholar.google.com/scholar_lookup?&title=&journal=Nature&doi=10.1038%2F353134a0&volume=353&pages=134-139&publication_year=1991&author=Germain%2CRN&author=Hendrix%2CLH"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="24"><p class="c-article-references__text" id="ref-CR24">Fuchs, R., Male, P. & Mellman, I. <i>J. biol. Chem.</i> <b>264</b>, 2212–2220 (1989).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaL1MXhtFSht70%3D" aria-label="CAS reference 24">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2914902" aria-label="PubMed reference 24">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 24" href="http://scholar.google.com/scholar_lookup?&title=&journal=J.%20biol.%20Chem.&volume=264&pages=2212-2220&publication_year=1989&author=Fuchs%2CR&author=Male%2CP&author=Mellman%2CI"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="25"><p class="c-article-references__text" id="ref-CR25">van der Sluijs, P. <i>et al.</i> <i>Proc. natn. Acad. Sci. U.S.A.</i> <b>88</b>, 6313–6317 (1991).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1073/pnas.88.14.6313" data-track-item_id="10.1073/pnas.88.14.6313" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1073%2Fpnas.88.14.6313" aria-label="Article reference 25" data-doi="10.1073/pnas.88.14.6313">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="ads reference" data-track-action="ads reference" href="http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1991PNAS...88.6313V" aria-label="ADS reference 25">ADS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaK3MXkvV2lsLw%3D" aria-label="CAS reference 25">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 25" href="http://scholar.google.com/scholar_lookup?&title=&journal=Proc.%20natn.%20Acad.%20Sci.%20U.S.A.&doi=10.1073%2Fpnas.88.14.6313&volume=88&pages=6313-6317&publication_year=1991&author=van%20der%20Sluijs%2CP"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="26"><p class="c-article-references__text" id="ref-CR26">Harter, C. & Mellman, I. <i>J. Cell Biol.</i> <b>117</b>, 311–325 (1992).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1083/jcb.117.2.311" data-track-item_id="10.1083/jcb.117.2.311" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1083%2Fjcb.117.2.311" aria-label="Article reference 26" data-doi="10.1083/jcb.117.2.311">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaK38XhvFWlsrw%3D" aria-label="CAS reference 26">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=1560028" aria-label="PubMed reference 26">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 26" href="http://scholar.google.com/scholar_lookup?&title=&journal=J.%20Cell%20Biol.&doi=10.1083%2Fjcb.117.2.311&volume=117&pages=311-325&publication_year=1992&author=Harter%2CC&author=Mellman%2CI"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="27"><p class="c-article-references__text" id="ref-CR27">Sadegh, N. S. & Germain, R. N. <i>Nature</i> <b>353</b>, 167–170 (1991).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1038/353167a0" data-track-item_id="10.1038/353167a0" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1038%2F353167a0" aria-label="Article reference 27" data-doi="10.1038/353167a0">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="ads reference" data-track-action="ads reference" href="http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1991Natur.353..167S" aria-label="ADS reference 27">ADS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 27" href="http://scholar.google.com/scholar_lookup?&title=&journal=Nature&doi=10.1038%2F353167a0&volume=353&pages=167-170&publication_year=1991&author=Sadegh%2CNS&author=Germain%2CRN"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="28"><p class="c-article-references__text" id="ref-CR28">Kelly, R. B. <i>Nature</i> <b>364</b>, 487–488 (1993).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1038/364487a0" data-track-item_id="10.1038/364487a0" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1038%2F364487a0" aria-label="Article reference 28" data-doi="10.1038/364487a0">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="ads reference" data-track-action="ads reference" href="http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1993Natur.364..487K" aria-label="ADS reference 28">ADS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:STN:280:DyaK3szjtVemuw%3D%3D" aria-label="CAS reference 28">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8336787" aria-label="PubMed reference 28">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 28" href="http://scholar.google.com/scholar_lookup?&title=&journal=Nature&doi=10.1038%2F364487a0&volume=364&pages=487-488&publication_year=1993&author=Kelly%2CRB"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="29"><p class="c-article-references__text" id="ref-CR29">Matter, K., Whitney, J. A., Yamamoto, E. M. & Mellman, I. <i>Cell</i> <b>74</b>, 1053–1064 (1993).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/0092-8674(93)90727-8" data-track-item_id="10.1016/0092-8674(93)90727-8" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2F0092-8674%2893%2990727-8" aria-label="Article reference 29" data-doi="10.1016/0092-8674(93)90727-8">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaK3sXms1OhtLg%3D" aria-label="CAS reference 29">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8402881" aria-label="PubMed reference 29">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 29" href="http://scholar.google.com/scholar_lookup?&title=&journal=Cell&doi=10.1016%2F0092-8674%2893%2990727-8&volume=74&pages=1053-1064&publication_year=1993&author=Matter%2CK&author=Whitney%2CJA&author=Yamamoto%2CEM&author=Mellman%2CI"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="30"><p class="c-article-references__text" id="ref-CR30">Loss, G. E. Jr, & Sant, A. J. <i>J. Immun.</i> <b>150</b>, 3187–3197 (1993).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaK3sXktVKkuro%3D" aria-label="CAS reference 30">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8468464" aria-label="PubMed reference 30">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 30" href="http://scholar.google.com/scholar_lookup?&title=&journal=J.%20Immun.&volume=150&pages=3187-3197&publication_year=1993&author=Loss%2CGE&author=Sant%2CAJ"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="31"><p class="c-article-references__text" id="ref-CR31">Bauerfeind, R., Regnier, V. A., Flatmark, T. & Huttner, W. B. <i>Neuron</i> <b>11</b>, 105–121 (1993).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/0896-6273(93)90275-V" data-track-item_id="10.1016/0896-6273(93)90275-V" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2F0896-6273%2893%2990275-V" aria-label="Article reference 31" data-doi="10.1016/0896-6273(93)90275-V">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaK2cXps1yrsw%3D%3D" aria-label="CAS reference 31">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8338662" aria-label="PubMed reference 31">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 31" href="http://scholar.google.com/scholar_lookup?&title=&journal=Neuron&doi=10.1016%2F0896-6273%2893%2990275-V&volume=11&pages=105-121&publication_year=1993&author=Bauerfeind%2CR&author=Regnier%2CVA&author=Flatmark%2CT&author=Huttner%2CWB"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="32"><p class="c-article-references__text" id="ref-CR32">Cresswell, P. <i>Proc. natn. Acad. Sci. U.S.A.</i> <b>82</b>, 8188–8192 (1985).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1073/pnas.82.23.8188" data-track-item_id="10.1073/pnas.82.23.8188" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1073%2Fpnas.82.23.8188" aria-label="Article reference 32" data-doi="10.1073/pnas.82.23.8188">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="ads reference" data-track-action="ads reference" href="http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1985PNAS...82.8188C" aria-label="ADS reference 32">ADS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaL28XmslWntg%3D%3D" aria-label="CAS reference 32">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 32" href="http://scholar.google.com/scholar_lookup?&title=&journal=Proc.%20natn.%20Acad.%20Sci.%20U.S.A.&doi=10.1073%2Fpnas.82.23.8188&volume=82&pages=8188-8192&publication_year=1985&author=Cresswell%2CP"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="33"><p class="c-article-references__text" id="ref-CR33">Schmid, S., Fuchs, R., Kielian, M., Helenius, A. & Mellman, I. <i>J. Cell Biol.</i> <b>108</b>, 1291–1300 (1989).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1083/jcb.108.4.1291" data-track-item_id="10.1083/jcb.108.4.1291" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1083%2Fjcb.108.4.1291" aria-label="Article reference 33" data-doi="10.1083/jcb.108.4.1291">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaL1MXhslSqtrc%3D" aria-label="CAS reference 33">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2925786" aria-label="PubMed reference 33">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 33" href="http://scholar.google.com/scholar_lookup?&title=&journal=J.%20Cell%20Biol.&doi=10.1083%2Fjcb.108.4.1291&volume=108&pages=1291-1300&publication_year=1989&author=Schmid%2CS&author=Fuchs%2CR&author=Kielian%2CM&author=Helenius%2CA&author=Mellman%2CI"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="34"><p class="c-article-references__text" id="ref-CR34">van der Sluijs, P., Hull, M., Webster, P., Goud, B. & Mellman, I. <i>Cell</i> <b>70</b>, 729–740 (1992).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/0092-8674(92)90307-X" data-track-item_id="10.1016/0092-8674(92)90307-X" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2F0092-8674%2892%2990307-X" aria-label="Article reference 34" data-doi="10.1016/0092-8674(92)90307-X">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaK38XlvVyrt70%3D" aria-label="CAS reference 34">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=1516131" aria-label="PubMed reference 34">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 34" href="http://scholar.google.com/scholar_lookup?&title=&journal=Cell&doi=10.1016%2F0092-8674%2892%2990307-X&volume=70&pages=729-740&publication_year=1992&author=van%20der%20Sluijs%2CP&author=Hull%2CM&author=Webster%2CP&author=Goud%2CB&author=Mellman%2CI"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="35"><p class="c-article-references__text" id="ref-CR35">Braunstein, N. S., Germain, R. N., Loney, K. & Berkowitz, N. <i>J. Immun.</i> <b>145</b>, 1635–1645 (1990).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaK3cXmtV2nurc%3D" aria-label="CAS reference 35">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=1697304" aria-label="PubMed reference 35">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 35" href="http://scholar.google.com/scholar_lookup?&title=&journal=J.%20Immun.&volume=145&pages=1635-1645&publication_year=1990&author=Braunstein%2CNS&author=Germain%2CRN&author=Loney%2CK&author=Berkowitz%2CN"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="36"><p class="c-article-references__text" id="ref-CR36">Rodriguez-Boulan, E. <i>et al.</i> <i>Meth. Cell Biol.</i> <b>32</b>, 37–56 (1989).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/S0091-679X(08)61166-8" data-track-item_id="10.1016/S0091-679X(08)61166-8" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2FS0091-679X%2808%2961166-8" aria-label="Article reference 36" data-doi="10.1016/S0091-679X(08)61166-8">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaK3cXktlOitrs%3D" aria-label="CAS reference 36">CAS</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 36" href="http://scholar.google.com/scholar_lookup?&title=&journal=Meth.%20Cell%20Biol.&doi=10.1016%2FS0091-679X%2808%2961166-8&volume=32&pages=37-56&publication_year=1989&author=Rodriguez-Boulan%2CE"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="37"><p class="c-article-references__text" id="ref-CR37">Matter, K., Hunziker, W. & Mellman, I. <i>Cell</i> <b>71</b>, 741–753 (1992).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/0092-8674(92)90551-M" data-track-item_id="10.1016/0092-8674(92)90551-M" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2F0092-8674%2892%2990551-M" aria-label="Article reference 37" data-doi="10.1016/0092-8674(92)90551-M">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DyaK3sXpvVOjsw%3D%3D" aria-label="CAS reference 37">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=1423629" aria-label="PubMed reference 37">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 37" href="http://scholar.google.com/scholar_lookup?&title=&journal=Cell&doi=10.1016%2F0092-8674%2892%2990551-M&volume=71&pages=741-753&publication_year=1992&author=Matter%2CK&author=Hunziker%2CW&author=Mellman%2CI"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="38"><p class="c-article-references__text" id="ref-CR38">Hanzel, D. <i>et al.</i> <i>Sem. Cell Biol.</i> <b>2</b>, 341–353 (1992).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 38" href="http://scholar.google.com/scholar_lookup?&title=&journal=Sem.%20Cell%20Biol.&volume=2&pages=341-353&publication_year=1992&author=Hanzel%2CD"> Google Scholar</a> </p></li></ol><p class="c-article-references__download u-hide-print"><a data-track="click" data-track-action="download citation references" data-track-label="link" rel="nofollow" href="https://citation-needed.springer.com/v2/references/10.1038/369113a0?format=refman&flavour=references">Download references<svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-download-medium"></use></svg></a></p></div></div></div></section></div><section aria-labelledby="author-information" data-title="Author information"><div class="c-article-section" id="author-information-section"><h2 class="c-article-section__title js-section-title js-c-reading-companion-sections-item" id="author-information">Author information</h2><div class="c-article-section__content" id="author-information-content"><h3 class="c-article__sub-heading" id="affiliations">Authors and Affiliations</h3><ol class="c-article-author-affiliation__list"><li id="Aff1"><p class="c-article-author-affiliation__address">Department of Cell Biology and The Center for Cell Imaging, Yale University School of Medicine, 333 Cedar Street, PO Box 208002, New Haven, Connecticut, 06520–8002, USA</p><p class="c-article-author-affiliation__authors-list">Sebastian Amigorena, James R. 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Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes | Nature