CINXE.COM

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "pubs.acs.org",cType: 'managed',cRay: '91cd070b0e453df6',cH: 'a_826jwMTP.sLTKl8O1kTlZj4WF_QSgIsvoSmjfpOSE-1741381280-1.2.1.1-6xQw6Dnt1DP_rNz8Zdnjy2d5Z1F8LtD.zVan264ZPwXehLEGzffcGz3Tm2dajv26',cUPMDTk: "\/doi\/abs\/10.1021\/ja403667s?__cf_chl_tk=BztpZgIX3XnHv0Kt6ba9JI__1LCc.EfwUYuOtyv60cw-1741381280-1.0.1.1-hawM3VRyGXPmr_gYNodO6mIvP8lHBQMEkJ8qVTROYWU",cFPWv: 'g',cITimeS: '1741381280',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/doi\/abs\/10.1021\/ja403667s?__cf_chl_f_tk=BztpZgIX3XnHv0Kt6ba9JI__1LCc.EfwUYuOtyv60cw-1741381280-1.0.1.1-hawM3VRyGXPmr_gYNodO6mIvP8lHBQMEkJ8qVTROYWU",md: "9KOqkgHRG_9nDuMjRYmXCQaE0rbdnWXzrGeO0ISpwUk-1741381280-1.2.1.1-KA7ihIl3K47KGVnuLETYjaqkS.FwF01fLFVnXkxncXBNHzjwd3VCzAoeAmXhn4kKpFStmHiiQ2kx.mczwIBxIWwvnjWzz1KFvAzmRutD3JQJvlk_QRpsiyTWQXgvB6uTSzKb2LzdehAUAT2.qbP9.v.6_0sBNIdsvdUE14IgshIsp.BcWO4VrDGWzG.2khGPqfWPV2tYbj29X8sWCJtZuME.1AyTpxbtBi78c.AzcPzdQdJjN.dKVQ7zKkmjSnugRsfugSPjANwe4kLTbCCsaHoc158avlKZEMb4I2SACwEgahR28JZ65M7QAxDmt47zwwHv409yNoFdyR9qbzO1L1Kb7LpJ_P4KWUPj.H2Xlg34wD4CCv9dlbeD_oEScBOk_8ko00Bin2w8bi7tNqVxwNLVYV8hox4EaTF0BPAfrJDgP.BGIrs5WF8ihk5teOssuniq8SnRvpcb62S6c5j.kWAav6yzarhYveUPCR7raPFlq91v3QJbMDG6XwQLNmRvrZ0nYUun4Jr_MWnuMTEOh4eC0pREeDmI5psJ0KdmWt.RXw5uHL2c8Mp88MTQYjPbjSvKvDizcx0qFgjCANkOvJjJsooO3YZpU5x8NTt5k_nxXF0JiBIlFMNsWWpa_lZFlnhsBXE_pDXgmtIujQ.QReDYqSsznBPUIKKu88kc_rb28ryZi3gJijKRqn5.tV83SYw2vc.r8zxhPLB12bqZYj5VaiAv3j7URR0EEQX.2mcYhAsOcFFCl.8wvuH.K46Y70_wmjtNV2Otu2aBorOWv1LI1oDQPK7CKky3JkTp0TcBx5G_oW.KSz6H5eRHrXcVtNWRk4f53HwxErvfBCK4D1.pg3caQP4bcrRRhNfoImXjoQSi9BtMlPyGmIvIHXU.LIkH8BtZ_FjFk4416QdJ0HFhUojv8dX7bSYbv1gEYWv6n__R70yS_dV1yQbBQfirBACaoOjbXyPf1NF1lRjj65Z5YN_ZBL90oEqwerdEHXzhvwLYKwnYVDaC.uBIdf7AsuPQc0hvG71QkwSMvHhT917ouO24YhpKk8fr3rSBFNxQ.912x8PLoxDf0oMXiAesLwpeRCJ2wM2QcVXz1W5kb6YX54sgrr_ppiHZI3ySib.1wC7Wy9aoP86NyJiKiA6jAGmuBJSCbh3uJxcv7m9Iibhq49mgLzQPx3RZP.089vradG8eAWWFTKG33g8lqZGIWDyd2KVziJcbOjyzleAF9yktvuhsf_eaGI_l0u8r.mQjm4qrZPpRzYZxpYKt139n",mdrd: "4kQX3sOKvHP2k1AKbhIg9m9R0kBYzv36bqgIaOSZEa8-1741381280-1.2.1.1-HWSeVLS2YmY1WPRrllnZ6qnbb_ThJIuaabDKX3IouWbXYPZZdpXAgQQOZQplC2v5pK0H6J.rJf426Z2G8khHmrzJK2RwEoHx87w3LRNIpNMwNZZNhV2pOOb3YJXRDP0N6_BFI243pH1Z_YR1ukfdjJVLXtdY5A7WKw6Dc3ycRIGZeID7h3JUDWsupp_t6gyn3XB17uOlQn16rfc62lN0rIZ1msbZmzH1mn3VJ97fGw2GHvwG4Gb5L8RJ5u9uGik4O1G3_m_C0xA9UWkrt4e4gnpe1.7MVAlRWLhyhhGo_T360yrddy5EcCYWpaEE3qlYhM8.wsraGfzkU.FvpJlDUfNYI08O.krwhidJJkAGEBUJwrrC_2Y4JXo_wr8lkTCa.8Vo6AxyyL9cvDHtByS9EYeRfb2JpkVijM2TKl3G_FgZ_eLKIwZAmSA.bJ8Cd6n.eR_mpPcOsT4GTKesjtt.nxQocLvnOczMw.OERC1xkcAQKlj_nNn4k4fiEZeXhHM13kYKUmQIgwRwW_5RYirKWIGH74aHdSUD7TQtd1H0ImPhQQUjapEVrTrmGiJT84G_jiY15wCadUju8oc4U1EQOwnaR09iztLFxD7HkVXBfIEpPJs76DQuomZRDI0x.sZBVVmhS1i2syoKHepmeBweWxrTDSd5ey.KJCek6xL.JCafq4hrcXNOKpJ0qfsJdretlK0VpYDPUV3h3XWfisOkn9J5C7Njqq9tR4V9ftZhFnvSZIvAfYg4Pf1sLPuWSDDQNz8ZjoKCU4OSyiOngAjvrx5gMxTL5.b6rOJ.J1F83wnuulK3vJUW63br96SYryIz0cJBvcLpGveL197hJYRn28lmkppgCprN3Cb104H_w0BRiL6O9r.GW2Xgdlz.2FmQbb2d9Y9MX53pWaGkbuHUVfQ8hVJDhTHzeCIWc7hF5.urkHegHk9EaWtgbztdg3Dscx0DKr5s7jN5TvAtMmJS9f2QqGRfG6kGNhEhPVecPZH2SjnL2oqmfyquXHraRKcv19MZyxOmDnugCXQ0Uy5.gwU7b0QiwSDJK2HK4uC9FaeQS9_Nr8OkP8O.fUy6mWOPcd9hiEjWeLqKmkNEeTcoNlzkDCvDt5MhR8hVKC98EPnDb2l4XjOLCmfP51X3Wq0EBl389t6FSsiWU4EyptApOdjCfjuB1Kw3pq70wyFzSuqK2zaFnisXPFfsPZ935y2MLE1y1ZC8LIaLJAdyPMDrEoLnD4zrQ7r4mDWjfKpd1m.4LaAP4scsP0uQdD74YmUefTibzu23w6wtEbsruQMBAP7nlQFqNbIt2_d5ASyK1Bf5YI0Mfa3KK9hJnQvPy62vSauxmdRsVEVrjmqJ3K.aLsceEnKXregaYAFJgePn9jUkFScz4tUTxqKymjIvH9yfOVvgzZt5zeRA.tQfG9tJ1KyqRv8JMve28KGj0bvdqfFXBV8lJuSiOpobmbQMiua52X9jLDwZQQedF4.0Sz9fm7Nicm7fAOhwt.4LX7z.11C099IGHYexloSHdz2x7RSt78Ezv8BxvQeRHyKCcRVfjnNltuKQqCbwqBTl4_wofVsCypjUyEGEPeCtgVNjpMaVUFPkieChmDeGZay2CN1WNPAL9NDYbOsfcUtTMTCjfk4ihdHXAooCM63BP_uQjnZ69GJbE8UlmoZYThGSnmMUa7P.B5DGzLTHfWDWgZUFyLSA_Nt5D2UI7xDcVfZrMni9DHN2JH8e4XWLgLDYBNEmdlBoNNQL8FFujE6NYCHW8VJ9OmK.A1iOrXaQgG6o2PaKbk0V.TLSYe1j9fHtC0UPbJ1h83D636XlIcrZGqIgrlJLmR_UTykYa1I9cyKkJI4KeQcTrX4Fa7Jflj4rVDPQQSvP2r.7Wbsgod63biM5xJF5RclR1HCTpVKoo4tLtEwMXAmXGR65FGKMJtGsi_q_i.p21elcFoMkYEI6uFp6bmPeiE.Ys6Q6KViKBgoAh.KL"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/g/orchestrate/chl_page/v1?ray=91cd070b0e453df6';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/doi\/abs\/10.1021\/ja403667s?__cf_chl_rt_tk=BztpZgIX3XnHv0Kt6ba9JI__1LCc.EfwUYuOtyv60cw-1741381280-1.0.1.1-hawM3VRyGXPmr_gYNodO6mIvP8lHBQMEkJ8qVTROYWU" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>