IgG Fc Proteins——Ideal Isotype Control for IgG Structured Drug Development

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<div class="pane_box_link"> <h2>Cell Activation</h2> <ul> <li><a href="/P5481-GMP-Monoclonal-Anti-Human-CD3-Antibody-%28OKT3%29-DMF-Filed.html" >Activation Antibodies</a></li> <li><a href="/A1595-ActiveMax®-Cytokines.html" >ActiveMax - Target Specific Beads</a></li> <li><a href="/P4836-ActiveMax%C2%AE-Human-T-cell-ActivationExpansion-CD3CD28-Beads-Premium-grade(Pre-GMP) (Pre-GMP)-DMF-Filed.html" >Activation CD3/CD28 Beads</a></li> <li><a href="/A2107-Solutions-for-T-Cell-Activation-and-Culture.html" >Solutions for T Cell Activation and Culture</a></li> <li><a href="/A2107-Solutions-for-T-Cell-Activation-and-Culture.html" >More >></a></li> </ul> </div> <div class="pane_box_link"> <h2>Cell Media Additives</h2> <ul> <li><a href="/A2560-ECMproteins.html" >Extracellular Matrix (ECM) Proteins</a></li> <li><a href="/A2145-BME.html" >Mogengel Matrix Basement Membrane Extracts</a></li> <li><a href="/A2612-Laminin.html" >Laminin Proteins</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Cell Culture Medium</h2> <ul> <li><a href="/A2660-T-cell-culture-media.html" >CelThera™ GMP T Cell Expansion Medium</a></li> </ul> </div> <div class="pane_box_link"> <h2>Others</h2> <ul> <li><a href="/A2398-Disease-and-human-models.html" >Organoid Toolbox</a></li> <li><a href="/A1888-Custom-GMP-Services.html" >Custom GMP Protein Services</a></li> <li><a href="/A1751-Key-Raw-Materials-for-Cell-and-Gene-Therapy.html" >More >></a></li> </ul> </div> </div> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Kits & Assay Reagents <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box4 pane_boxB"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/Product_hand05.jpg" alt="Kits & Assay Reagents"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>ELISA</h2> <ul> <li><a 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Products</a></li> <li><a href="/A1167-Solutions-for-COVID-19-vaccine-safety-and-immunogenicity-evaluation.html" >Workflow for Vaccine R&D</a></li> </ul> </div> <div class="pane_box_link"> <h2>Varicella Zoster Virus</h2> <ul> <li><a href="/search-keywords-Glycoprotein E (VZV).html" >Glycoprotein E (VZV Antigen)</a></li> <li><a href="/search-keywords-VZV-nature-1-w-na1.html" >Anti-Glycoprotein E Antibody</a></li> <li><a href="/A2374-VZV-vaccine.html" >More >></a></li> </ul> </div> <div class="pane_box_link"> <h2>Influenza Virus</h2> <ul> <li><a href="/L-141-Hemagglutinin%20(HA).html" >Natural HA Trimer</a></li> <li><a href="/L-332-Neuraminidase%20(NA).html" >Natural NA Tetramer</a></li> <li><a href="/A2523-Flu.html" >HA & NA Antibody</a></li> <li><a href="/A2502-Influenza-Vaccine-Research-Customized-Services.html" >Customized Service</a></li> <li><a href="/A2523-Flu.html" >More >></a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Respiratory 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>Anti-RABV Glycoprotein Antibody Kit </a></li> <li><a href="/A2438-RABV.html" >More >></a></li> </ul> </div> <div class="pane_box_link"> <h2>Herpes Virus</h2> <ul> <li><a href="/A2374-VZV-vaccine.html" >VZV</a></li> <li><a href="/A1658-virustop.html#module=ViruStop7" >HSV</a></li> <li><a href="/A1658-virustop.html#module=ViruStop13" >EBV</a></li> <li><a href="/A1658-virustop.html#module=ViruStop19" >HCMV</a></li> <li><a href="/A2642-Herpesviruses.html" >More >></a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Other Viruses</h2> <ul> <li><a href="/A1658-virustop.html#module=ViruStop2" >Influenza virus</a></li> <li><a href="/A1658-virustop.html#module=ViruStop4" >MPXV</a></li> <li><a href="/A1658-virustop.html#module=ViruStop5" >HIV</a></li> <li><a href="/A2438-RABV.html" >RABV</a></li> <li><a href="/A1658-virustop.html" >More >></a></li> </ul> </div> <div class="pane_box_link"> <h2>ViruStop Services</h2> <ul> <li><a 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>Deep Array Probes</a></li> <li><a href="/A2183-DBC.html" >More >></a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2> Experimental Instruments and Equipments</h2> <ul> <li><a href="/P7052-Automatic-Nucleic-Acid-Extraction-System.html" >Automatic Nucleic Acid Extraction System</a></li> <li><a href="/P7052-Automatic-Nucleic-Acid-Extraction-System.html" >More >></a></li> </ul> </div> </div> </div> </li> <div class="layui-menu-body-titleA"> Search by Modality </div> <li class="layui-menu-item-parent" > <div class="layui-menu-body-title upA"> <a href="/A2471-Cell-_Therapy-_Solutions.html">Cell Therapy </a><i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel layui-pane2_1 layui-pane2_1_1" > <div class="layui-menu-body-title layui-menu-body-title2"> Cell Therapy </div> <ul> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Discovery and Development <i class="layui-icon 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href="/search-keywords-G4S%20Linker.html" >Anti-G4S linker Antibody</a></li> <li><a href="/L-422-Protein%20L.html" >Protein L</a></li> </ul> </div> <div class="pane_box_link"> <h2>Other Target Proteins</h2> <ul> <li><a href="/A1656-MHC-Class-I-Complex-Custom-Service.html" >MHC-peptide Complexes</a></li> <li><a href="/A1536-Proteins-for-Neuroscience.html" >Aneuro - Proteins for Neuroscience</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>General Proteins</h2> <ul> <li><a href="/A1670-Streptavidin(SA)-Series-Products.html" >SA Series Products</a></li> </ul> </div> <div class="pane_box_link"> <h2>Drug Screening Service</h2> <ul> <li><a href="/A1151-SPR-BLI-analytical-service.html" >SPR /BLI analytical service</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Companion Diagnostics Development</h2> <ul> <li><a href="/A2176-IHC-antibody.html" >IHC Antibodies</a></li> <li><a href="/A2246-Immunohistochemistry-%28IHC%29-Kit.html" >Immunohistochemistry (IHC) Kit</a></li> </ul> </div> </div> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Manufacturing <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box2_2 pane_boxD"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/home_rightA_b.jpg" alt="CMC-Manufacturing"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Cell Culture Products</h2> <ul> <li><a href="/A1798-cell-culture-cytokines.html" >Cell Culture Growth Factors & Antibodies</a></li> <li><a href="/A2660-T-cell-culture-media.html" >CelThera™ GMP T Cell Expansion Medium</a></li> <li><a href="/A1595-ActiveMax®-Cytokines.html" >ActiveMax Cell Activation Beads</a></li> <li><a href="/A2560-ECMproteins.html" >Extracellular Matrix (ECM) Proteins</a></li> <li><a href="/A2097-iPSC-Culturing.html" >CMC Production Process of iPSC-based Cell Therapy</a></li> <li><a href="/A2612-Laminin.html" >Laminin Proteins for Clinical iPSC Banking</a></li> <li><a href="/A1904-Organoid-Culture.html" >Cytokines for Organoid Culture</a></li> <li><a href="/A1813-Neural-Factors.html" >Aneuro - Neural Factors</a></li> <li><a href="/A2495-TcellCMC.html" >CMC Production Process of Adoptive T Cell Therapies</a></li> </ul> </div> <div class="pane_box_link"> <h2>Premium(Pre-GMP) grade Raw Materials</h2> <ul> <li><a href="/A1751-Key-Raw-Materials-for-Cell-and-Gene-Therapy.html" >Premium(Pre-GMP) Growth Factors</a></li> <li><a href="/P5481-GMP-Monoclonal-Anti-Human-CD3-Antibody-%28OKT3%29-DMF-Filed.html" >GMP Grade Antibodies</a></li> <li><a href="/P5787-GMP-GENIUS%E2%84%A2Nuclease-DMF-Filed.html" >GMP Grade GENIUS™Nuclease </a></li> <li><a href="/P7181-GMP-Salt-Active-GENIUS%E2%84%A2Nuclease.html" >Salt Active GENIUS™Nuclease</a></li> <li><a href="/A1595-ActiveMax®-Cytokines.html" >ActiveMax Cell Activation Beads</a></li> <li><a href="/A1751-Key-Raw-Materials-for-Cell-and-Gene-Therapy.html" >Key Raw Materials for CGT</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Nucleic Acid Removal Products</h2> <ul> <li><a href="/P5787-GMP-GENIUS%E2%84%A2Nuclease-DMF-Filed.html" >GMP Grade GENIUS™Nuclease </a></li> <li><a href="/P7181-GMP-Salt-Active-GENIUS%E2%84%A2Nuclease.html" >Salt Active GENIUS™Nuclease</a></li> </ul> </div> <div class="pane_box_link"> <h2>Gene Editing Products</h2> <ul> <li><a href="/A1657-CRISPR-Cas-technology.html" >GENPower - Cas Enzymes</a></li> <li><a href="/A1301-enzyme-products.html#mRNA_enzymeA" >mRNA Synthesis Enzymes</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Large-Scale Manufacturing</h2> <ul> <li><a href="/A1751-Key-Raw-Materials-for-Cell-and-Gene-Therapy.html" >GMP-grade Raw Materials</a></li> <li><a href="/A1888-Custom-GMP-Services.html" >GMP Protein Services</a></li> </ul> </div> </div> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Quality Control <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box2_3 pane_boxD"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/home_rightA_c.jpg" alt="CMC-Quality Control"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Residual Detection-resDetect</h2> <ul> <li><a href="/A2146-Nuclease-Detection-Kits.html" target="_blank" >Residual Host Cell DNA / RNA Detection Kits</a></li> <li><a href="/search-keywords-Activity.html" target="_blank" >RNase / DNase Detection Kits</a></li> <li><a href="/P7571-resDetect%E2%84%A2-GENIUS%E2%84%A2-Nuclease-ELISA-Kit-%28Residue-Testing%29.html" target="_blank" >GENIUS™ Nuclease Residual Detection Kit</a></li> <li><a href="/P7814-resDetect%E2%84%A2-BSA-ELISA-Kit.html" target="_blank" >Residual BSA ELISA Kit</a></li> <li><a href="/A1557-GMP-Grade-Cytokines.html#pro" target="_blank" >Residual Cell Culture Materials Detection Kits</a></li> <li><a href="/P6991-resDetect%E2%84%A2-Kanamycin-ELISA-Kit.html" target="_blank" >Residual Antibiotics Detection Kits</a></li> <li><a href="/P7281-resDetect%E2%84%A2-HIV-1-p24-ELISA-Kit-%28Residue-Testing%29.html" target="_blank" >Residual HIV-1 p24 ELISA Kit</a></li> <li><a href="/search-keywords-Mycoplasma.html" target="_blank">Mycoplasma Rapid Detection Kit</a></li> <li><a href="/P7954-Recombinant-Factor-C-Endotoxin-Detection-Kit.html" target="_blank">Recombinant Factor C Endotoxin Detection Kit</a></li> <li><a href="/A2504-resDetect-CGT.html" target="_blank" >CGT CMC Manufacturing Process Residue Detection Solutions</a></li> <li><a href="https://www.acrobiosystems.com/A2331-resDetect.html" >More >></a></li> </ul> </div> <div class="pane_box_link"> <h2>CAR Detection Tools</h2> <ul> <li><a href="/A1332-Star-Staining-Proteins-Platform.html" >Star Staining - Fluorescent Labeled Proteins</a></li> <li><a href="/A1118-mAb-for-Anti-CD19-CAR-Detection-Flow-Cytometry-Validated.html" >Anti-FMC63 Antibody</a></li> <li><a href="/L-1788-G4S%C2%A0linker.html" >Anti-G4s Linker Antibody</a></li> <li><a href="/A1320-Anti-Idiotypic-Antibody.html" >Anti-idiotypic Antibody Development Service</a></li> <li><a href="/A1391-IgG-Fc-Proteins%E2%80%94%E2%80%94Ideal-Isotype-Control-for-IgG-Structured-Drug-Development.html" >ComboX Isotype Controls</a></li> </ul> </div> <div class="pane_box_link"> <h2>Potency Assays</h2> <ul> <li><a href="/A1781-Cytokine-detection-ELISA-kits.html" >Cytokine Release Assay Kits - ClinMax</a></li> <li><a href="/search-keywords-Th1/Th2 cytokine.html" >Multiplex Cytokine Assay Kits</a></li> <li><a href="/A2221-Stable-cell-line.html" >Overexpression cell line - CellInsight</a></li> <li><a href="/A2219-Cell-Line-Customize-Service.html" >Cell Line Customization services</a></li> </ul> </div> </div> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Pre-clinical Research <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box2_4 pane_boxD"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/home_rightA_d.jpg" alt="Preclinical Studies"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Pharmacokinetics Studies</h2> <ul> <li><a href="/A1332-Star-Staining-Proteins-Platform.html" >Star Staining - Fluorescent Labeled Proteins</a></li> <li><a href="/A1118-mAb-for-Anti-CD19-CAR-Detection-Flow-Cytometry-Validated.html" >Anti-FMC63 Antibody</a></li> <li><a href="/L-1788-G4S%C2%A0linker.html" >Anti-G4s Linker Antibody</a></li> <li><a href="/A1320-Anti-Idiotypic-Antibody.html" >Anti-idiotypic Antibody Development Service</a></li> <li><a href="/A1326-Enzyme-Linked-Immunosorbent-Assay-%28ELISA%29-Service.html" >PK ELISA Development Service</a></li> </ul> </div> <div class="pane_box_link"> <h2>Pharmacodynamics Studies</h2> <ul> <li><a href="/A2398-Disease-and-human-models.html" >Organoid Toolbox</a></li><li><a href="/A1904-Organoid-Culture.html" >Organoid Culture Cytokines</a></li> <li><a href="/A1718-Pre-formed-Fibrils-(PFFs).html" >Pre-formed Fibrils (Aneuro)</a></li> <li><a href="/A2145-BME.html" >Mogengel Matrix for Organoid Culture</a></li> <li><a href="/A2183-DBC.html" >Diagnostic Biochips</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Toxicity Studies</h2> <ul> <li><a href="/A1781-Cytokine-detection-ELISA-kits.html" >Cytokine Release Assay Kits - ClinMax</a></li> <li><a href="/search-keywords-Th1/Th2 cytokine.html" >Multiplex Cytokine Assay Kits</a></li> <li><a href="/A2398-Disease-and-human-models.html" >Organoid Toolbox</a></li> </ul> </div> <div class="pane_box_link"> 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href="/A1326-Enzyme-Linked-Immunosorbent-Assay-%28ELISA%29-Service.html" >PK ELISA Development Service</a></li> </ul> </div> <div class="pane_box_link"> <h2>Toxicity Studies</h2> <ul> <li><a href="/A1781-Cytokine-detection-ELISA-kits.html" >Cytokine Release Assay Kits - ClinMax</a></li> <li><a href="/search-keywords-Th1/Th2 cytokine.html" >Multiplex Cytokine Assay Kits</a></li> <li><a href="/A2398-Disease-and-human-models.html" >Organoid Toolbox</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Immunogenicity Studies</h2> <ul> <li><a href="/A1118-mAb-for-Anti-CD19-CAR-Detection-Flow-Cytometry-Validated.html" >Anti-FMC63 Antibody</a></li> <li><a href="/P5420-Anti-CD19-%28FMC63%29-CAR-Immunogenicity-ELISA-Kit.html" >Immunogenicity Anti-FMC63 ELISA kit</a></li> <li><a href="/A1332-Star-Staining-Proteins-Platform.html" >Star Staining - Fluorescent Labeled Proteins</a></li> <li><a href="/A1320-Anti-Idiotypic-Antibody.html" >Anti-idiotypic Antibody Development Service</a></li> </ul> </div> </div> </div> </li> </ul> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title upA"> Gene Therapy <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel layui-pane2_1 layui-pane2_1_2"> <div class="layui-menu-body-title layui-menu-body-title2"> Gene Therapy </div> <ul> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Discovery and Development <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box2_1 pane_boxD pane_boxA upA_suow"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/home_rightB_a.jpg" alt="Discovery & Development"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Gene Editing</h2> <ul> <li><a href="/A1657-CRISPR-Cas-technology.html" >GENPower - Cas Enzymes</a></li> 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lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Manufacturing <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box2_2 pane_boxD"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/home_rightB_b.jpg" alt="CMC-Manufacturing"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Premium(Pre-GMP) grade Raw Materials</h2> <ul> <li><a href="/A1751-Key-Raw-Materials-for-Cell-and-Gene-Therapy.html" >Premium(Pre-GMP) Growth Factors</a></li> </ul> </div> <div class="pane_box_link"> <h2>Gene Editing Products</h2> <ul> <li><a href="/A1657-CRISPR-Cas-technology.html" >GENPower - Cas Enzymes</a></li> <li><a href="/A1301-enzyme-products.html#mRNA_enzymeA" >mRNA Synthesis Enzymes</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Nucleic Acid Removal Products</h2> <ul> <li><a href="/L-1211-Nuclease.html" >Nucleic Acid 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href="/P7814-resDetect%E2%84%A2-BSA-ELISA-Kit.html" target="_blank" >Residual BSA ELISA Kit</a></li> <li><a href="/P6991-resDetect%E2%84%A2-Kanamycin-ELISA-Kit.html" target="_blank" >Residual Antibiotics Detection Kits</a></li> <li><a href="/A2504-resDetect-CGT.html" target="_blank" >CGT CMC Manufacturing Process Residue Detection Solutions</a></li> <li><a href="/search-keywords-Mycoplasma.html" target="_blank">Mycoplasma Rapid Detection Kit</a></li> <li><a href="/P7954-Recombinant-Factor-C-Endotoxin-Detection-Kit.html" target="_blank">Recombinant Factor C Endotoxin Detection Kit</a></li> <li><a href="https://www.acrobiosystems.com/A2331-resDetect.html" >More >></a></li> </ul> </div> <div class="pane_box_link"> <h2>Potency Assays</h2> <ul> <li><a href="/A1781-Cytokine-detection-ELISA-kits.html" >Cytokine Release Assay Kits - ClinMax</a></li> <li><a href="/search-keywords-Th1/Th2 cytokine.html" >Multiplex Cytokine Assay Kits</a></li> </ul> </div> <div class="pane_box_link"> <h2>AAV Titer Quantitation</h2> <ul> <li><a href="/P7031-AAV5-Titration-ELISA-Kit-%28Fast%29.html" >AAV5 Titration ELISA Kit (Fast)</a></li> <li><a href="/P7157-AAV5-Titration-ELISA-Kit.html" >AAV5 Titration ELISA Kit </a></li> <li><a href="/P7823-AAV3-Titration-ELISA-Kit-%28Fast%29.html" >AAV3 Titration ELISA Kit (Fast) </a></li> <li><a href="/P7100-AAV3-Titration-ELISA-Kit.html" >AAV3 Titration ELISA Kit</a></li> <li><a href="/P7735-AAV8-Titration-ELISA-Kit-%28Fast%29.html" >AAV8 Titration ELISA Kit (Fast)</a></li> <li><a href="/P7736-AAV8-Titration-ELISA-Kit.html" >AAV8 Titration ELISA Kit</a></li> </ul> </div> </div> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Pre-clinical Research <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box2_4 pane_boxD"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/home_rightB_d.jpg" alt="Preclinical Studies"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Pharmacodynamics Studies</h2> <ul> <li><a href="/A2398-Disease-and-human-models.html" >Organoid Toolbox</a></li><li><a href="/A1904-Organoid-Culture.html" >Organoid Culture Cytokines</a></li> <li><a href="/A1718-Pre-formed-Fibrils-(PFFs).html" >Pre-formed Fibrils (Aneuro)</a></li> <li><a href="/A2145-BME.html" >Mogengel Matrix for Organoid Culture</a></li> <li><a href="/A2183-DBC.html" >Diagnostic Biochips</a></li> </ul> </div> <div class="pane_box_link"> <h2>Security Studies</h2> <ul> <li><a href="/search-keywords-AAV%20antibody%20kit.html" >Anti-AAV Antibody ELISA Kit</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Toxicity Studies</h2> <ul> <li><a href="/A1781-Cytokine-detection-ELISA-kits.html" >Cytokine Release Assay Kits - ClinMax</a></li> <li><a href="/search-keywords-Th1/Th2 cytokine.html" >Multiplex Cytokine Assay Kits</a></li> <li><a href="/A2398-Disease-and-human-models.html" >Organoid Toolbox</a></li> </ul> </div> <div class="pane_box_link"> <h2>Audit & Documentation support</h2> <ul> <li><a href="/A1148-FDA-DMF-Filed-Proteins.html" >FDA DMF Filed Proteins</a></li> <li><a href="/A1557-GMP-Grade-Cytokines.html" >GMP Regulatory Support Files</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Companion Diagnostics Tools</h2> <ul> <li><a href="/A2176-IHC-antibody.html" >IHC Antibodies</a></li> <li><a href="/A2246-Immunohistochemistry-%28IHC%29-Kit.html" >Immunohistochemistry (IHC) Kit</a></li> </ul> </div> </div> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Clinical Research <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box2_5 pane_boxD"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/home_rightB_e.jpg" alt="Clinical Studies"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Toxicity Studies</h2> <ul> <li><a href="/A1781-Cytokine-detection-ELISA-kits.html" >Cytokine Release Assay Kits - ClinMax</a></li> <li><a href="/search-keywords-Th1/Th2 cytokine.html" >Multiplex Cytokine Assay Kits</a></li> <li><a href="/A2398-Disease-and-human-models.html" >Organoid Toolbox</a></li> </ul> </div> <div class="pane_box_link"> <h2>Security Studies</h2> <ul> <li><a href="/search-keywords-AAV%20antibody%20kit.html" >Anti-AAV Antibody ELISA Kit</a></li> </ul> </div> </div> </div> </li> </ul> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title upA"> <a href="/A2356-Therapeutic-Antibody-Page.html" >Therapeutic Antibodies </a><i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel layui-pane2_1 layui-pane2_1_3"> <div class="layui-menu-body-title layui-menu-body-title2"> Therapeutic Antibodies </div> <ul> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Discovery and Development <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box2_1 pane_boxD pane_boxA upA_suow"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/home_rightC_a.jpg" alt="Discovery & Development"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Target Proteins</h2> <ul> <li><a href="/A1288-Cytokine.html" >Cytokine Targets</a></li> <li><a href="/A974-Immune-Checkpoint-Proteins.html" >Checkpoint Proteins</a></li> <li><a href="/A2117-Agonist-Target-Proteins.html" >Agonist</a></li> <li><a href="/A1290-Transmembrane-Proteins-Platform.html" >FLAG</a></li> <li><a href="/A1536-Proteins-for-Neuroscience.html" >Aneuro</a></li> <li><a href="/A1265-Tumor-microenvironment.html" >Tumor Microenvironment</a></li> <li><a href="/A1222-Bispecific-antibody-targets-and-more.html" >Bispecifc Antibody Targets</a></li> <li><a href="/A1656-MHC-Class-I-Complex-Custom-Service.html" >MHC Complexes</a></li> </ul> </div> <div class="pane_box_link"> <h2>Antibody Screening</h2> <ul> <li><a href="/A716-Biotinylated-Protein.html" >Biotinylated Proteins</a></li> <li><a href="/A1096-Inhibitor-Screening-Kits.html" >Inhibitor Screening Kits</a></li> <li><a href="/A1332-Star-Staining-Proteins-Platform.html" >Star Staining Fluorescent Labeled Proteins</a></li> <li><a href="/A1128-Pre-Coupling-Magnetic-Beads.html" >Pre-coupled Magnetic Beads</a></li> <li><a href="/A1670-Streptavidin(SA)-Series-Products.html" >SA series Products ComboX</a></li> <li><a href="/A1969-Recombinant-Antibody-Services.html" >Recombinant Antibody Expression Services</a></li> <li><a href="/A1151-SPR-BLI-analytical-service.html" >SPR /BLI analytical service</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Fc Proteins</h2> <ul> <li><a href="/A1391-IgG-Fc-Proteins%E2%80%94%E2%80%94Ideal-Isotype-Control-for-IgG-Structured-Drug-Development.html" >IgG Fc Proteins</a></li> <li><a href="/A712-Fc-Receptor-Proteins.html" >Fc Receptor</a></li> <li><a href="/A1394-FcRn%EF%BC%88Neonatal-Fc-Receptor%EF%BC%89.html" >Neonatal Fc Receptor</a></li> <li><a href="/P7366-Human-FcRn-binding-Kit-%28TR-FRET%29.html" >FcRn Binding Kit</a></li> </ul> </div> <div class="pane_box_link"> <h2>Cell Line (CellInsight)</h2> <ul> <li><a href="/A2221-Stable-cell-line.html" >Overexpression cell line</a></li> <li><a href="/A2219-Cell-Line-Customize-Service.html" >Cell Line Customization services</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Companion Diagnostics</h2> <ul> <li><a href="/A2176-IHC-antibody.html" >IHC Antibodies</a></li> <li><a href="/A2246-Immunohistochemistry-%28IHC%29-Kit.html" >Immunohistochemistry (IHC) Kit</a></li> </ul> </div> </div> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Manufacturing <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box2_2 pane_boxD"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/home_rightC_b.jpg" alt="CMC-Manufacturing"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Nucleic Acid Removal</h2> <ul> <li><a href="/P5787-GMP-GENIUS%E2%84%A2Nuclease-DMF-Filed.html" >GMP GENIUS Nuclease</a></li> <li><a href="/P7181-GMP-Salt-Active-GENIUS%E2%84%A2Nuclease.html" >Salt Active GENIUS™Nuclease</a></li> </ul> </div> </div> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Quality Control <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box2_3 pane_boxD"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/home_rightC_c.jpg" alt="CMC-Quality Control"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Residual Detection-resDetect</h2> <ul> <li><a href="/A2146-Nuclease-Detection-Kits.html" >Host DNA/Protein Quantitative Kits</a></li> <li><a href="/P7433-resDetect%E2%84%A2-Universal-Protein-A-Quick-ELISA-Kit-%28Boiling-free%29.html" >Residual Affinity Ligands Detection Kits</a></li> <li><a href="/A1557-GMP-Grade-Cytokines.html#pro" >Residual Cell Culture Materials Detection Kits</a></li> <li><a href="/P7571-resDetect%E2%84%A2-GENIUS%E2%84%A2-Nuclease-ELISA-Kit-%28Residue-Testing%29.html" >GENIUS™ Nuclease Residual Detection Kit</a></li> <li><a href="/P6991-resDetect%E2%84%A2-Kanamycin-ELISA-Kit.html" >Residual Antibiotics Detection Kits</a></li> <li><a href="/A2543-resDetect-Antibody.html" >Therapeutic antibodies CMC Manufacturing Process Residue Detection Solutions</a></li> <li><a href="/search-keywords-Mycoplasma.html" >Mycoplasma Rapid Detection Kit</a></li> <li><a href="/P7954-Recombinant-Factor-C-Endotoxin-Detection-Kit.html" >Recombinant Factor C Endotoxin Detection Kit</a></li> <li><a href="https://www.acrobiosystems.com/A2331-resDetect.html" >More >></a></li> </ul> </div> <div class="pane_box_link"> <h2>Other Quality Control Products</h2> <ul> <li><a href="/A2221-Stable-cell-line.html" >Overexpression cell line</a></li> <li><a href="/A1391-IgG-Fc-Proteins%E2%80%94%E2%80%94Ideal-Isotype-Control-for-IgG-Structured-Drug-Development.html" >IgG Isotype Control</a></li> <li><a href="/A2154-Tool-enzymes.html" >Enzymes for Antibody Characterization Analysis</a></li> <li><a href="/A1794-MALS-UNcle-Platform.html" >Quality Characterization Analytical Services</a></li> <li><a href="/A2219-Cell-Line-Customize-Service.html" >Cell Line Customization services</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Cytokine Release Detection</h2> <ul> <li><a href="/A1781-Cytokine-detection-ELISA-kits.html" >Cytokine ELISA Kits</a></li> </ul> </div> </div> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Preclinical Research <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box2_4 pane_boxD"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/home_rightC_d.jpg" alt="Preclinical Studies"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Pharmacokinetics Studies</h2> <ul> <li><a href="/A716-Biotinylated-Protein.html" >Biotinylated Proteins</a></li> <li><a href="/A1670-Streptavidin(SA)-Series-Products.html" >SA series Products ComboX</a></li> <li><a href="/A1089-Anti-idiotypic-Antibodies.html" >Anti-idiotypic Antibodies</a></li> <li><a href="/A1320-Anti-Idiotypic-Antibody.html" >Anti-idiotypic Antibody Development Service</a></li> <li><a href="/A1078-ELISA-Assay-Kits-for-Therapeutic-Antibodies.html" >PK ELISA Assays</a></li> <li><a href="/A1326-Enzyme-Linked-Immunosorbent-Assay-%28ELISA%29-Service.html" >PK ELISA Development Service</a></li> </ul> </div> <div class="pane_box_link"> <h2>Toxicity Studies</h2> <ul> <li><a href="/A1781-Cytokine-detection-ELISA-kits.html" >Cytokine Release Assay Kits - ClinMax</a></li> <li><a href="/search-keywords-Th1/Th2 cytokine.html" >Multiplex Cytokine Assay Kits</a></li> <li><a href="/A2398-Disease-and-human-models.html" >Organoid Toolbox</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Immunogenicity Studies</h2> <ul> <li><a href="/A1320-Anti-Idiotypic-Antibody.html" >Anti-idiotypic & ADA Assay Development Service</a></li> </ul> </div> <div class="pane_box_link"> <h2>Pharmacodynamics Studies</h2> <ul> <li><a href="/A2398-Disease-and-human-models.html" >Organoid Toolbox</a></li><li><a href="/A1904-Organoid-Culture.html" >Organoid Culture Cytokines</a></li> <li><a href="/A1718-Pre-formed-Fibrils-(PFFs).html" >Pre-formed Fibrils (Aneuro)</a></li> <li><a href="/A2145-BME.html" >Mogengel Matrix for Organoid Culture</a></li> <li><a href="/A2183-DBC.html" >Diagnostic Biochips</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Audit & Documentation support</h2> <ul> <li><a href="/A1148-FDA-DMF-Filed-Proteins.html" >FDA DMF Filed Proteins</a></li> <li><a href="/A1557-GMP-Grade-Cytokines.html" >GMP Regulatory Support Files</a></li> </ul> </div> <div class="pane_box_link"> <h2>Companion Diagnostics Tools</h2> <ul> <li><a href="/A2176-IHC-antibody.html" >IHC Antibodies</a></li> <li><a href="/A2246-Immunohistochemistry-%28IHC%29-Kit.html" >Immunohistochemistry (IHC) Kit</a></li> </ul> </div> </div> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Clinical Research <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box2_5 pane_boxD"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/home_rightC_e.jpg" alt="Clinical Studies"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Pharmacokinetics Studies</h2> <ul> <li><a href="/A716-Biotinylated-Protein.html" >Biotinylated Proteins</a></li> <li><a href="/A1670-Streptavidin(SA)-Series-Products.html" >SA series Products ComboX</a></li> <li><a href="/A1089-Anti-idiotypic-Antibodies.html" >Anti-idiotypic Antibodies</a></li> <li><a href="/A1320-Anti-Idiotypic-Antibody.html" >Anti-idiotypic Antibody Development Service</a></li> <li><a href="/A1078-ELISA-Assay-Kits-for-Therapeutic-Antibodies.html" >PK ELISA Assays</a></li> <li><a href="/A1326-Enzyme-Linked-Immunosorbent-Assay-%28ELISA%29-Service.html" >PK ELISA Development Service</a></li> </ul> </div> <div class="pane_box_link"> <h2>Immunogenicity Studies</h2> <ul> <li><a href="/A1320-Anti-Idiotypic-Antibody.html" >Anti-idiotypic Antibody ADA Development Service</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Toxicity Studies</h2> <ul> <li><a href="/A1781-Cytokine-detection-ELISA-kits.html" >Cytokine Release Assay Kits - ClinMax</a></li> <li><a href="/search-keywords-Th1/Th2 cytokine.html" >Multiplex Cytokine Assay Kits</a></li> <li><a href="/A2398-Disease-and-human-models.html" >Organoid Toolbox</a></li> </ul> </div> </div> </div> </li> </ul> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title upA"> Antibody Drug Conjugates <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel layui-pane2_1 layui-pane2_1_4"> <div class="layui-menu-body-title layui-menu-body-title2"> Antibody Drug Conjugates </div> <ul> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Discovery and Development <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box2_1 pane_boxD pane_boxA upA_suow"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/home_rightD_a.jpg" alt="Discovery & Development"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Target Proteins</h2> <ul> <li><a href="/A1210-Targets-for-Antibody-Drug-Conjugates.html#module=kit1" >ADC Drug Targets</a></li> <li><a href="/A1288-Cytokine.html" >Cytokine Targets</a></li> <li><a href="/A974-Immune-Checkpoint-Proteins.html" >Checkpoint Proteins</a></li> <li><a href="/A2117-Agonist-Target-Proteins.html" >Agonist</a></li> <li><a href="/A1290-Transmembrane-Proteins-Platform.html" >FLAG</a></li> <li><a href="/A1536-Proteins-for-Neuroscience.html" >Aneuro</a></li> <li><a href="/A1265-Tumor-microenvironment.html" >Tumor Microenvironment</a></li> <li><a href="/A1222-Bispecific-antibody-targets-and-more.html" >Bispecifc Antibody Targets</a></li> <li><a href="/A1656-MHC-Class-I-Complex-Custom-Service.html" >MHC Complexes</a></li> </ul> </div> <div class="pane_box_link"> <h2>Antibody Screening</h2> <ul> <li><a href="/A716-Biotinylated-Protein.html" >Biotinylated Proteins</a></li> <li><a href="/A1096-Inhibitor-Screening-Kits.html" >Inhibitor Screening Kits</a></li> <li><a href="/A1332-Star-Staining-Proteins-Platform.html" >Star Staining Fluorescent Labeled Proteins</a></li> <li><a href="/A1128-Pre-Coupling-Magnetic-Beads.html" >Pre-coupled Magnetic Beads</a></li> <li><a href="/A1670-Streptavidin(SA)-Series-Products.html" >SA series Products ComboX</a></li> <li><a href="/A1969-Recombinant-Antibody-Services.html" >Recombinant Antibody Expression Services</a></li> <li><a href="/A1151-SPR-BLI-analytical-service.html" >SPR /BLI analytical service</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Fc Proteins</h2> <ul> <li><a href="/A1391-IgG-Fc-Proteins%E2%80%94%E2%80%94Ideal-Isotype-Control-for-IgG-Structured-Drug-Development.html" >IgG Fc Proteins</a></li> <li><a href="/A712-Fc-Receptor-Proteins.html" >Fc Receptor</a></li> <li><a href="/A1394-FcRn%EF%BC%88Neonatal-Fc-Receptor%EF%BC%89.html" >Neonatal Fc Receptor</a></li> <li><a href="/P7366-Human-FcRn-binding-Kit-%28TR-FRET%29.html" >FcRn Binding Kit</a></li> </ul> </div> <div class="pane_box_link"> <h2>ADC Reagents</h2> <ul> <li><a href="/A2584-ADC-Conjugation-Kit.html" >AGLink Conjugation Kit</a></li> <li><a href="/A1210-Targets-for-Antibody-Drug-Conjugates.html" >Proteases for Peptide Linker</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Cell Line (CellInsight)</h2> <ul> <li><a href="/A2221-Stable-cell-line.html" >Overexpression cell line</a></li> <li><a href="/A2219-Cell-Line-Customize-Service.html" >Cell Line Customization services</a></li> </ul> </div> <div class="pane_box_link"> <h2>Companion Diagnostics</h2> <ul> <li><a href="/A2176-IHC-antibody.html" >IHC Antibodies</a></li> <li><a href="/A2246-Immunohistochemistry-%28IHC%29-Kit.html" >Immunohistochemistry (IHC) Kit</a></li> </ul> </div> </div> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Manufacturing <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box2_2 pane_boxD"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/home_rightD_b.jpg" alt="CMC-Manufacturing"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Nucleic Acid Removal</h2> <ul> <li><a href="/P5787-GMP-GENIUS%E2%84%A2Nuclease-DMF-Filed.html" >GMP GENIUS Nuclease</a></li> <li><a href="/P7181-GMP-Salt-Active-GENIUS%E2%84%A2Nuclease.html" >Salt Active GENIUS™Nuclease</a></li> </ul> </div> <div class="pane_box_link"> <h2>Conjugation Kits</h2> <ul> <li><a href="/A2584-ADC-Conjugation-Kit.html" >AGLink Conjugation Kit</a></li> </ul> </div> </div> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Quality Control <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box2_3 pane_boxD"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/home_rightD_c.jpg" alt="CMC-Quality Control"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Residual Detection-resDetect</h2> <ul> <li><a href="/A2146-Nuclease-Detection-Kits.html" >Host DNA/Protein Quantitative Kits</a></li> <li><a href="/P7433-resDetect%E2%84%A2-Universal-Protein-A-Quick-ELISA-Kit-%28Boiling-free%29.html" >Residual Affinity Ligands Detection Kits</a></li> <li><a href="/A1557-GMP-Grade-Cytokines.html#pro" >Residual Cell Culture Materials Detection Kits</a></li> <li><a href="/P7571-resDetect%E2%84%A2-GENIUS%E2%84%A2-Nuclease-ELISA-Kit-%28Residue-Testing%29.html" >GENIUS™ Nuclease Residual Detection Kit</a></li> <li><a href="/search-keywords-Mycoplasma.html" >Mycoplasma Rapid Detection Kit</a></li> <li><a href="/P7954-Recombinant-Factor-C-Endotoxin-Detection-Kit.html" >Recombinant Factor C Endotoxin Detection Kit</a></li> <li><a href="https://www.acrobiosystems.com/A2331-resDetect.html" >More >></a></li> </ul> </div> <div class="pane_box_link"> <h2>Other Quality Control Products</h2> <ul> <li><a href="/A2221-Stable-cell-line.html" >Overexpression cell line</a></li> <li><a href="/A1391-IgG-Fc-Proteins%E2%80%94%E2%80%94Ideal-Isotype-Control-for-IgG-Structured-Drug-Development.html" >IgG Isotype Control</a></li> <li><a href="/A2154-Tool-enzymes.html" >Enzymes for Antibody Characterization Analysis</a></li> <li><a href="/A1794-MALS-UNcle-Platform.html" >Quality Characterization Analytical Services</a></li> 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src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/home_rightD_d.jpg" alt="Preclinical Studies"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Pharmacokinetics Studies</h2> <ul> <li><a href="/A716-Biotinylated-Protein.html" >Biotinylated Proteins</a></li> <li><a href="/A1670-Streptavidin(SA)-Series-Products.html" >SA series Products ComboX</a></li> <li><a href="/A2226-Anti-payload-antibodies.html" >Anti-payload Antibodies</a></li> <li><a href="/A1089-Anti-idiotypic-Antibodies.html" >Anti-idiotypic Antibodies</a></li> <li><a href="/A1320-Anti-Idiotypic-Antibody.html" >Anti-idiotypic Antibody Development Service</a></li> <li><a href="/A1078-ELISA-Assay-Kits-for-Therapeutic-Antibodies.html" >PK ELISA Assays</a></li> <li><a href="/A1326-Enzyme-Linked-Immunosorbent-Assay-%28ELISA%29-Service.html" >PK ELISA Development Service</a></li> </ul> </div> <div class="pane_box_link"> <h2>Pharmacodynamics Studies</h2> <ul> <li><a 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Nowadays, IgG antibodies have been used in the treatment of cancer and autoimmune diseases with great success. Fc-mediated effector functions (ADCC, ADCP, CDC) play an important role in the therapeutic effects among the mechanisms by which various IgG antibody drugs exert their therapeutic effects.</p><p class="public_text_dec">There are four distinct subclasses of human IgG with decreasing concentrations, namely IgG1, IgG2, IgG3, and IgG4 (approximately 61%，32%，4%，3%). Although all subclasses are more than 90% identical at the amino acid level and have similar spatial structures. They are highly conserved in terms of the length of the hinge regions, the number of disulfide bonds, and the Fc effect function. These regions are involved in binding to both Ig-FC receptors (FcγR) and C1q. As a result, the different subclasses have different effector functions, both in terms of triggering FcγR-expressing cells, resulting in phagocytosis (ADCP) or antibody-dependent cell mediated cytotoxicity (ADCC), and activating complement (CDC).</p><div><div class="img_text imgOpen"><img src="/static/main/images/lgG_fc/lgG_fc_1.jpg" data-category="Human IgG subclasses"/> <br/>            <span>Human IgG subclasses</span></div><div class="img_p"><p class="public_text_dec"><strong>IgG1</strong> is the most potential subclass in tumor immunotherapy. In addition to Human IgG1 can also effectively bind Mouse Fcγs, significant effects can also be observed in vivo models. The half-life of IgG1 in the body is relatively long. Moreover, from an industrial perspective, IgG1 can be highly expressed and can be purified by protein-A, which makes it highly economical and stable. Therefore, IgG1 has become the most commonly used IgG subtype.</p><p class="public_text_dec"><strong>IgG2</strong> is mainly used to neutralize the antigen or block the binding of receptor ligands. The ADCC effect is very weak. Although the binding to C1q is relatively weak, but it can still trigger the CDC effect when the antigen or antibody solubility is high. At the same time, IgG2 is the only subtype that can bind to FcγRIIa (CD32a). In the early days, only antibodies targeting EGFR were marketed based on the IgG2 subtype. With the rise of immune checkpoint research, more and more drugs of the IgG2 subtype have entered the clinic and are on the market.</p><div class="public_text_dec"><strong>IgG3</strong> has a longer hinge region, a larger molecular weight and a stronger biological function. IgG3 has the strongest binding ability to FcγRs, which can trigger ADCC and ADCP (antibody dependent cellular phagocytosis), and the CDC effect is stronger than that of IgG1. However, the half-life of IgG3 is shorter, because R435 is different from H435 of other IgG molecules, which affects its binding to FcRn. Considering that pharmacokinetics, frequently administration is required, it is rarely used to develop antibody drugs and from an economic point of view. IgG3 antibodies cannot be purified by protein-A, which is commonly used in industrialization, and are easy to form multimers. This will undoubtedly greatly increase the purification cost, which further inhibits the development of antibodies based on this subtype.</div></div><div class="clear"></div></div><div class="public_text_dec"><strong>IgG4</strong> has a shorter hinge region and weakly binds to FcγRs other than FcγRI (CD64), but may have a stronger affinity than clone-related IgG1, and may compete with IgG1 for binding to tumor antigens. IgG4 binds to inhibitory FcγRIIb with higher affinity than other IgG subtypes. It can bind to FcγRIIb with other antibodies such as IgG1 to inhibit the function mediated by FcγRs. IgG4 can also exchange Fab-arm with other IgG4 to produce monovalent antibodies with bispecific functions or antibodies with increased affinity. IgG4 cannot immobilize complement and bind to activated FcγRs on immune effector cells, which may lead to antibody-mediated CDC, ADCC and ADCP blockade. Different from the previous mechanism that antibodies rely on ADCC activity to kill cells, the mechanism of PD-1 antibody or PD-L1 antibody is to block the PD-1/PD-L1 pathway and release the inhibition of T cells, etc. For example, Opdivo and Keytruda are designed with the IgG4 subtype with weak ADCC activity.</div><div class="clear"></div><div class="public_text_dec" style="text-align:center; font-weight:bold; margin-top:20px;">FDA approved tumor-therapeutic antibodies with different IgG subclasses</div><div class="public_text_dec" style="text-align:center;" id="new_ciations_box"><img src="/static/main/images/lgG_fc/lgG_fc_2.jpg"/></div><div class="public_text_dec" style="text-align:right; font-weight:bold; margin-bottom:20px;"><em>https://doi.org/10.1186/s13045-020-00876-4</em></div><div class="clear"></div><div><div class="img_text imgOpen" id="mp4"><img src="/static/main/images/lgG_fc/lgG_fc_3.gif" style="margin:10px auto !important;" data-category="The structure of IgG Fc (shown in green)"/><br/>The structure of IgG Fc (shown in green)</div><div class="img_p"><div class="public_text_dec" style="margin-top:10px;">In terms of structure, monoclonal antibodies currently used for autoimmune diseases, inflammation and tumors all use IgG backbone. In addition, IgG-like bispecific antibodies，ADC and IgG Fc fusion proteins are also inseparable from the structural framework of IgG. In addition to increasing the serum half-life, the structure of Fc also improves other properties, such as stability and solubility, and at the same time it facilitates the production process and simplifies the downstream purification. In terms of action, as one of the most effective biotherapeutics at present, an important aspect of antibodies is that they can specifically bind to antigens and at the same time stimulate immune response. In addition to specific binding of Fab fragments to target antigen epitopes, antibody-derived Fc fragments can also bind to Fc receptors on target cells and other cells.</div><div class="public_text_dec">Based on scientific rigor, in order to prove that the binding of the antibody to the target antigen, the effect of the target fusion protein is specific. The non-specific binding signal or basic function verification generated by the IgG Fc fragment cannot be ignored, and a suitable isotype control product is indispensable.</div><div class="public_text_dec" style="font-weight:bold;">To facilitate the development of IgG structured drug development including monoclonal antibodies, IgG-like bispecific antibodies and IgG Fc-fusion proteins, ACROBiosystems can provide you with a series of IgG Fc proteins. Our recombinant protein IgG Fc only contains the hinge region, CH2, CH3 sequence, but not the Fab sequence. It can be used as an ideal isotype control for monoclonal antibodies, IgG-like bispecific antibodies, ADC and IgG Fc- fusion drugs in the process of drug screening, functional verification and so on.</div></div></div><div class="clear"></div><div class="public_text_dec" style="margin-top:10px; font-weight:bold;">In addition, our IgG Fc proteins can be used as endogenous IgG for competitive validation of FcRn binding to FcRn targeted antibody drugs. (<a href="/A1447-Decrease-or-increase-two-therapeutic-strategies-via-FcRn-mediated-mechanism.html" style="color:#cc3536; text-decoration:underline;" target="_blank">Click here to view: Increase or Decrease: The Two Therapeutic Strategies via FcRn-Mediated Mechanism</a>)</div></div><div class="clear"></div><div class="productSection"><div class="productTit">Product Features</div><div class="s-con cf"><div class="layui-col-space10 " style="float: left;width: 100%;"><div class="layui-col-md7"><p><img src="/static/main/images/mutants/pentagram1.png" style="margin-right:10px; margin-top:-4px;" width="20"/><strong>Expressed by HEK293 cells: </strong>which realize post-translational glycosylation and other modifications and correct protein folding</p><p></p><table width="100%" border="0"><tbody><tr class="firstRow"><td rowspan="3" width="38%" valign="top"><img src="/static/main/images/mutants/pentagram1.png" style="margin-right:10px; margin-top:-4px;" width="20"/><strong>Various species and subclasses: </strong></td><td width="62%" valign="top"><p>Human IgG1 Fc, IgG2 Fc, IgG3 Fc, IgG4 Fc</p></td></tr><tr><td valign="top"><p>Mouse IgG1 Fc, IgG2a Fc, IgG2b Fc</p></td></tr><tr><td valign="top"><p>Llama IgG2b Fc，Rabbit IgG Fc</p></td></tr></tbody></table><p></p><p><img src="/static/main/images/mutants/pentagram1.png" style="margin-right:10px; margin-top:-4px;" width="20"/><strong>Various tags: </strong><span style="color:#cc3536;">Tag Free</span>，Avitag<sup style="color:#cc3536;">TM</sup>，His Tag，gD Tag，Flag Tag，Avitag<sup style="color:#cc3536;">TM</sup> &His tag</p></div><div class="layui-col-md5"><p><img src="/static/main/images/mutants/pentagram1.png" style="margin-right:10px; margin-top:-4px;" width="20"/><strong>Low endotoxin: </strong>Less than 1.0 EU/μg by the LAL method</p><p></p><table width="100%" border="0"><tbody><tr class="firstRow"><td rowspan="2" width="25%" valign="top"><img src="/static/main/images/mutants/pentagram1.png" style="margin-right:10px; margin-top:-4px;" width="20"/><strong>High purity: </strong></td><td width="75%" valign="top"><p>more than 95% as verified by SDS-PAGE</p></td></tr><tr><td valign="top"><p>more than 90% as verified by SEC-MALS</p></td></tr></tbody></table><p></p><p><img src="/static/main/images/mutants/pentagram1.png" style="margin-right:10px; margin-top:-4px;" width="20"/><strong>High bioactivity: </strong>verified by ELISA & SPR with free protocols</p></div></div></div></div><div class="clear"></div><div class="productSection"><div class="productTit">Product List</div><div class="clear"></div><table class="public_table layui-table pro_table background-table"><thead><tr class="firstRow"><th>Molecule</th><th>Cat. No.</th><th style="width: 8%">Species</th><th class="pro_desc">Product Description</th><th style="width: 10%">Preorder/Order</th></tr></thead><tbody><tr><td><a style="color:#cc3536;text-decoration: underline;" href="/L-290-IgG1 Fc.html" target="_blank">IgG1 Fc</a></td><td><a style="color:#cc3536;text-decoration: underline;" href="/P263-Human-IgG1-Fc-Protein-Tag-Free-%28MALS-verified%29.html" target="_blank">FCC-H5214</a></td><td style="line-height:30px;" align="center">Human</td><td class="pro_desc">Human IgG1 Fc Protein, Tag Free (MALS verified)</td><td><center><p class="tab_btn_protocol" style="text-align:center;font-weight: bold;"><a href="/P263-Human-IgG1-Fc-Protein-Tag-Free-%28MALS-verified%29.html" target="_blank" style="color:#FFF;text-decoration: none;">Order</a></p></center></td></tr><tr><td><a style="color:#cc3536;text-decoration: underline;" href="/L-290-IgG1 Fc.html" target="_blank">IgG1 Fc</a></td><td><a style="color:#cc3536;text-decoration: underline;" href="/P2388-Biotinylated-Human-IgG1-Fc-protein-Avitag%E2%84%A2-%28MALS-verified%29.html" target="_blank">IG1-H8213</a></td><td style="line-height:30px;" align="center">Human</td><td class="pro_desc">Biotinylated Human IgG1 Fc protein, Avitag™ (MALS verified)</td><td><center><p class="tab_btn_protocol" style="text-align:center;font-weight: bold;"><a href="/P2388-Biotinylated-Human-IgG1-Fc-protein-Avitag%E2%84%A2-%28MALS-verified%29.html" target="_blank" style="color:#FFF;text-decoration: none;">Order</a></p></center></td></tr><tr><td><a style="color:#cc3536;text-decoration: underline;" href="/L-290-IgG1 Fc.html" target="_blank">IgG1 Fc</a></td><td><a style="color:#cc3536;text-decoration: underline;" href="/P1975-Human-IgG1-Fc-Protein-His-Tag-%28MALS-verified%29.html" target="_blank">IG1-H5225</a></td><td style="line-height:30px;" align="center">Human</td><td class="pro_desc">Human IgG1 Fc Protein, His Tag (MALS verified)</td><td><center><p class="tab_btn_protocol" style="text-align:center;font-weight: bold;"><a href="/P1975-Human-IgG1-Fc-Protein-His-Tag-%28MALS-verified%29.html" target="_blank" style="color:#FFF;text-decoration: none;">Order</a></p></center></td></tr><tr><td><a style="color:#cc3536;text-decoration: underline;" href="/L-290-IgG1 Fc.html" target="_blank">IgG1 Fc</a></td><td><a style="color:#cc3536;text-decoration: underline;" href="/P3032-Human-IgG1-Fc-Protein-Flag-Tag-%28MALS-verified%29.html" target="_blank">IG1-H52C9</a></td><td style="line-height:30px;" align="center">Human</td><td class="pro_desc">Human IgG1 Fc Protein, Flag Tag (MALS verified)</td><td><center><p class="tab_btn_protocol" style="text-align:center;font-weight: bold;"><a href="/P3032-Human-IgG1-Fc-Protein-Flag-Tag-%28MALS-verified%29.html" target="_blank" style="color:#FFF;text-decoration: none;">Order</a></p></center></td></tr><tr><td><a style="color:#cc3536;text-decoration: underline;" href="/L-290-IgG1 Fc.html" target="_blank">IgG1 Fc</a></td><td><a style="color:#cc3536;text-decoration: underline;" href="/P3030-Human-IgG1-Fc-Protein-gD-Tag-%28MALS-verified%29.html" target="_blank">IG1-H52G6</a></td><td style="line-height:30px;" align="center">Human</td><td class="pro_desc">Human IgG1 Fc Protein, gD Tag (MALS verified)</td><td><center><p class="tab_btn_protocol" style="text-align:center;font-weight: bold;"><a href="/P3030-Human-IgG1-Fc-Protein-gD-Tag-%28MALS-verified%29.html" target="_blank" style="color:#FFF;text-decoration: none;">Order</a></p></center></td></tr><tr><td><a style="color:#cc3536;text-decoration: underline;" href="/L-758-IgG2 Fc.html" target="_blank">IgG2 Fc</a></td><td><a style="color:#cc3536;text-decoration: underline;" href="/P722-Human-IgG2-Fc-Protein-Tag-Free-%28MALS--SPR%A0verified%29.html" target="_blank">IG2-H5206</a></td><td style="line-height:30px;" align="center">Human</td><td class="pro_desc">Human IgG2 Fc Protein, Tag Free (MALS & SPR verified)</td><td><center><p class="tab_btn_protocol" style="text-align:center;font-weight: bold;"><a href="/P722-Human-IgG2-Fc-Protein-Tag-Free-%28MALS--SPR%A0verified%29.html" target="_blank" style="color:#FFF;text-decoration: none;">Order</a></p></center></td></tr><tr><td><a style="color:#cc3536;text-decoration: underline;" href="/L-755-IgG3 Fc.html" target="_blank">IgG3 Fc</a></td><td><a style="color:#cc3536;text-decoration: underline;" href="/P1502-Human-IgG3-Fc-Protein-Tag-Free-%28MALS--SPR-verified%29.html" target="_blank">IG3-H5200</a></td><td style="line-height:30px;" align="center">Human</td><td class="pro_desc">Human IgG3 Fc Protein, Tag Free (MALS & SPR verified)</td><td><center><p class="tab_btn_protocol" style="text-align:center;font-weight: bold;"><a href="/P1502-Human-IgG3-Fc-Protein-Tag-Free-%28MALS--SPR-verified%29.html" target="_blank" style="color:#FFF;text-decoration: none;">Order</a></p></center></td></tr><tr><td><a style="color:#cc3536;text-decoration: underline;" href="/L-757-IgG4 Fc.html" target="_blank">IgG4 Fc</a></td><td><a style="color:#cc3536;text-decoration: underline;" href="/P721-Human-IgG4-Fc-Protein-Tag-Free-%28MALS--SPR-verified%29.html" target="_blank">IG4-H5205</a></td><td style="line-height:30px;" align="center">Human</td><td class="pro_desc">Human IgG4 Fc Protein, Tag Free (MALS & SPR verified)</td><td><center><p class="tab_btn_protocol" style="text-align:center;font-weight: bold;"><a href="/P721-Human-IgG4-Fc-Protein-Tag-Free-%28MALS--SPR-verified%29.html" target="_blank" style="color:#FFF;text-decoration: none;">Order</a></p></center></td></tr><tr><td><a style="color:#cc3536;text-decoration: underline;" href="/L-290-IgG1 Fc.html" target="_blank">IgG1 Fc</a></td><td><a style="color:#cc3536;text-decoration: underline;" href="/P706-Mouse-IgG1-Fc-Protein-Tag-Free-%28HPLC%A0verified%29.html" target="_blank">IG1-M5208</a></td><td style="line-height:30px;" align="center">Mouse</td><td class="pro_desc">Mouse IgG1 Fc Protein, Tag Free (HPLC verified)</td><td><center><p class="tab_btn_protocol" style="text-align:center;font-weight: bold;"><a href="/P706-Mouse-IgG1-Fc-Protein-Tag-Free-%28HPLC%A0verified%29.html" target="_blank" style="color:#FFF;text-decoration: none;">Order</a></p></center></td></tr><tr><td><a style="color:#cc3536;text-decoration: underline;" href="/L-290-IgG1 Fc.html" target="_blank">IgG1 Fc</a></td><td><a style="color:#cc3536;text-decoration: underline;" href="/P3505-Biotinylated-Mouse-IgG1-Fc-protein-Avitag%E2%84%A2-%28MALS-verified%29.html" target="_blank">IG1-M8211</a></td><td style="line-height:30px;" align="center">Mouse</td><td class="pro_desc">Biotinylated Mouse IgG1 Fc protein, Avitag™ (MALS verified)</td><td><center><p class="tab_btn_protocol" style="text-align:center;font-weight: bold;"><a href="/P3505-Biotinylated-Mouse-IgG1-Fc-protein-Avitag%E2%84%A2-%28MALS-verified%29.html" target="_blank" style="color:#FFF;text-decoration: none;">Order</a></p></center></td></tr><tr><td><a style="color:#cc3536;text-decoration: underline;" href="/L-756-IgG2a Fc.html" target="_blank">IgG2a Fc</a></td><td><a style="color:#cc3536;text-decoration: underline;" href="/P703-Mouse-IgG2a-Fc-Protein-Tag-Free-%28MALS-verified%29.html" target="_blank">IGA-M5207</a></td><td style="line-height:30px;" align="center">Mouse</td><td class="pro_desc">Mouse IgG2a Fc Protein, Tag Free (MALS verified)</td><td><center><p class="tab_btn_protocol" style="text-align:center;font-weight: bold;"><a href="/P703-Mouse-IgG2a-Fc-Protein-Tag-Free-%28MALS-verified%29.html" target="_blank" style="color:#FFF;text-decoration: none;">Order</a></p></center></td></tr><tr><td><a style="color:#cc3536;text-decoration: underline;" href="/L-756-IgG2a Fc.html" target="_blank">IgG2a Fc</a></td><td><a style="color:#cc3536;text-decoration: underline;" href="/P2071-Biotinylated-Mouse-IgG2a-Fc-Protein-Avitag%E2%84%A2-%28MALS-verified%29.html" target="_blank">IGA-M8210</a></td><td style="line-height:30px;" align="center">Mouse</td><td class="pro_desc">Biotinylated Mouse IgG2a Fc Protein, Avitag™ (MALS verified)</td><td><center><p class="tab_btn_protocol" style="text-align:center;font-weight: bold;"><a href="/P2071-Biotinylated-Mouse-IgG2a-Fc-Protein-Avitag%E2%84%A2-%28MALS-verified%29.html" target="_blank" style="color:#FFF;text-decoration: none;">Order</a></p></center></td></tr><tr><td><a style="color:#cc3536;text-decoration: underline;" href="/L-922-IgG2b Fc.html" target="_blank">IgG2b Fc</a></td><td><a style="color:#cc3536;text-decoration: underline;" href="/P3673-Mouse-IgG2b-Fc-Protein-Tag-Free-%28MALS-verified%29.html" target="_blank">IGB-M5203</a></td><td style="line-height:30px;" align="center">Mouse</td><td class="pro_desc">Mouse IgG2b Fc Protein, Tag Free (MALS verified)</td><td><center><p class="tab_btn_protocol" style="text-align:center;font-weight: bold;"><a href="/P3673-Mouse-IgG2b-Fc-Protein-Tag-Free-%28MALS-verified%29.html" target="_blank" style="color:#FFF;text-decoration: none;">Order</a></p></center></td></tr><tr><td><a style="color:#cc3536;text-decoration: underline;" href="/L-922-IgG2b Fc.html" target="_blank">IgG2b Fc</a></td><td><a style="color:#cc3536;text-decoration: underline;" href="/P2679-Llama-IgG2b-Fc-Protein-Tag-Free-%28MALS-verified%29.html" target="_blank">IGB-L5204</a></td><td style="line-height:30px;" align="center">Llama</td><td class="pro_desc">Llama IgG2b Fc Protein, Tag Free (MALS verified)</td><td><center><p class="tab_btn_protocol" style="text-align:center;font-weight: bold;"><a href="/P2679-Llama-IgG2b-Fc-Protein-Tag-Free-%28MALS-verified%29.html" target="_blank" style="color:#FFF;text-decoration: none;">Order</a></p></center></td></tr><tr><td><a style="color:#cc3536;text-decoration: underline;" href="/L-858-IgG Fc.html" target="_blank">IgG Fc</a></td><td><a style="color:#cc3536;text-decoration: underline;" href="/P3670-Rabbit-IgG-Fc-Protein-Tag-Free-%28MALS-verified%29.html" target="_blank">IGG-R5203</a></td><td style="line-height:30px;" align="center">Rabbit</td><td class="pro_desc">Rabbit IgG Fc Protein, Tag Free (MALS verified)</td><td><center><p class="tab_btn_protocol" style="text-align:center;font-weight: bold;"><a href="/P3670-Rabbit-IgG-Fc-Protein-Tag-Free-%28MALS-verified%29.html" target="_blank" style="color:#FFF;text-decoration: none;">Order</a></p></center></td></tr></tbody></table></div><div class="productSection"><div class="productTit">Verification Data</div><h3 class="h3-title">High purity verified by SDS-PAGE and SEC-MALS</h3><div class="public_img_text_box public_img_l_r layui-col-space10 "><div class="layui-col-md6" style="padding: 20px;" id="p1"><div class="imgBox imgOpen"><img src="/static/main/images/lgG_fc/lgG_fc_4.jpg" data-category="FCC-H5214_MALS"/></div><p class="imgText"><em>2Human IgG Fc, Tag Free (Cat. No. <a style="color:#cc3536;text-decoration: underline;" href="/P263-Human-IgG1-Fc-Protein-Tag-Free-%28MALS-verified%29.html" target="_blank">FCC-H5214</a>) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%. The purity of Human IgG Fc, Tag Free (Cat. No. <a style="color:#cc3536;text-decoration: underline;" href="/P263-Human-IgG1-Fc-Protein-Tag-Free-%28MALS-verified%29.html" target="_blank">FCC-H5214</a>) is more than 95% and the molecular weight of this protein is around 51-65 kDa verified by SEC-MALS.</em></p></div><div class="layui-col-md6" style="padding: 20px;" id="p2"><div class="imgBox imgOpen"><img src="/static/main/images/lgG_fc/lgG_fc_5.jpg" data-category="IG4-H5205_MALS"/></div><p class="imgText"><em>Human IgG4 Fc, Tag Free (Cat. No. <a style="color:#cc3536;text-decoration: underline;" href="/P721-Human-IgG4-Fc-Protein-Tag-Free-%28MALS--SPR-verified%29.html" target="_blank">IG4-H5205</a>) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%. The purity of Human IgG4 Fc, Tag Free (Cat. No. <a style="color:#cc3536;text-decoration: underline;" href="/P721-Human-IgG4-Fc-Protein-Tag-Free-%28MALS--SPR-verified%29.html" target="_blank">IG4-H5205</a>) is more than 90% and the molecular weight of this protein is around 54-66kDa verified by SEC-MALS.</em></p></div></div><div class="clear"></div><div class="h3-title">The Secondary Structure of IgG Fc Verified Using the Microfluidic Modulaton Spectroscopy (MMS) Platform <span style="font-style: italic;">(Collaborated With RedShiftBio)</span></div><div class="public_img_text_box public_img_l_r"><div class="layui-col-md6"><div class="imgBox imgOpen"><img src="/static/main/images/lgG_fc/lgGfcData01.jpg" style="height:300px;" alt="The Secondary Structure of IgG Fc Verified Using the Microfluidic Modulaton Spectroscopy (MMS) Platform" data-category="The Secondary Structure of IgG Fc Verified Using the Microfluidic Modulaton Spectroscopy (MMS) Platform"/></div></div><div class="layui-col-md6"><div class="imgBox imgOpen"><img src="/static/main/images/lgG_fc/lgGfcData02.jpg" style="height:300px;" alt="The Secondary Structure of IgG Fc Verified Using the Microfluidic Modulaton Spectroscopy (MMS) Platform" data-category="The Secondary Structure of IgG Fc Verified Using the Microfluidic Modulaton Spectroscopy (MMS) Platform"/></div></div></div><p class="imgText" style="text-align: center;"><em>MMS analysis showed that different IgG Fc subclasses exhibit distinct secondary structures. Specifically, IgG1 and IgG2 exhibit the highest degree of structural similarity, while IgG3 and IgG4 show the greatest structural diﬀerence.</em></p><p style="font-weight:bold;text-align: center;"><a href="https://drive.google.com/drive/folders/1G7gB_h2n72FYEkENAPHnv8F_A9bnkkQn?usp=sharing " style="color: #cc3536;text-decoration: underline;">Explore the In-depth Secondary Structure Analysis of IgG Fc</a><img src="/static/main/hand.png" style="width: 24px; margin: 10px 0 0 0;" alt=""/></p><div class="clear"></div><h3 class="h3-title">High Bioactivity verified by ELISA&SPR</h3><div class="clear"></div><div class="public_img_text_box public_img_l_r layui-col-space10 "><div class="layui-col-md6" style="padding: 20px;" id="p3"><div class="imgBox imgOpen"><img src="/static/main/images/lgG_fc/lgG_fc_6.jpg" data-category="IFCC-H5214_ELISA"/></div><p class="imgText"><em>Immobilized Human CD64, His Tag (Cat. No. <a style="color:#cc3536;text-decoration: underline;" href="/P3118-Human-Fc-gamma-RI--CD64-Protein-His-Tag-%28SPR--BLI--MALS-verified%29.html" target="_blank">FCA-H52H1</a>) at 1 μg/mL (100 μL/well) can bind Human IgG Fc, Tag Free (Cat. No. <a style="color:#cc3536;text-decoration: underline;" href="/P263-Human-IgG1-Fc-Protein-Tag-Free-%28MALS-verified%29.html" target="_blank">FCC-H5214</a>) with a linear range of 1-16 ng/mL.</em></p><center><label class="btn_protocol des_protocol"><a style="color:#FFFFFF" data-sign="FCC-H5214">Protocol</a></label></center></div><div class="layui-col-md6" style="padding: 20px;" id="p4"><div class="imgBox imgOpen"><img src="/static/main/images/lgG_fc/lgG_fc_7.jpg" data-category="IG1-H8213_ELISA"/></div><p class="imgText"><em>Immobilized Recombinant Protein G, His Tag (Cat. No. <a style="color:#cc3536;text-decoration: underline;" href="/P225-Recombinant-Protein-G-Protein-His-Tag.html" target="_blank">RPG-S3140</a>) at 2 μg/mL (100 μL/well) can bind Biotinylated Human IgG1 Fc, Avitag (Cat. No. IG1-H8213) with a linear range of 0.013-0.512 μg/mL.</em></p><center><label class="btn_protocol des_protocol"><a style="color:#FFFFFF" data-sign="IG1-H8213">Protocol</a></label></center></div></div><div class="clear"></div><h3 class="h3-title">Affinity verified by SPR</h3><div class="clear"></div><div class="public_img_text_box public_img_l_r layui-col-space10 "><div class="layui-col-md6" style="padding:20px;"><div class="imgBox imgOpen"><img src="/static/main/images/lgG_fc/lgG_fc_8.jpg" data-category="FCC-H5214_SPR"/></div><p class="imgText"><em>Human FCGRT&B2M Heterodimer Protein, His Tag (Cat. No. <a style="color:#cc3536;text-decoration: underline;" href="/P2876-Human-FcRn--FCGRTB2M-Heterodimer-Protein-His-Tag-%28SPR--BLI--MALS-verified%29.html" target="_blank">FCN-H52W7</a>) captured on CM5 Chip via anti-His antibody can bind Human IgG1 Fc, Tag Free (Cat. No. <a style="color:#cc3536;text-decoration: underline;" href="/P263-Human-IgG1-Fc-Protein-Tag-Free-%28MALS-verified%29.html" target="_blank">FCC-H5214</a>) with an affinity constant of 0.957 μM as determined in SPR assay (Biacore 8K).</em></p><center><label class="btn_protocol des_protocol"><a style="color:#FFFFFF" data-sign="FCC-H5214">Protocol</a></label></center></div><div class="layui-col-md6" style="padding: 20px;"><div class="imgBox imgOpen"><img src="/static/main/images/lgG_fc/lgG_fc_9.jpg" data-category="IG4-H5205_SPR"/></div><p class="imgText"><em>Human FCGRT&B2M Heterodimer Protein, His Tag (Cat. No. <a style="color:#cc3536;text-decoration: underline;" href="/P2876-Human-FcRn--FCGRTB2M-Heterodimer-Protein-His-Tag-%28SPR--BLI--MALS-verified%29.html" target="_blank">FCN-H52W7</a>) captured on CM5 Chip via anti-His antibody can bind Human IgG4 Fc, Tag Free (Cat. No. IG4-H5205) with an affinity constant of 0.715 μM as determined in SPR assay (Biacore 8K). </em></p><center><label class="btn_protocol des_protocol"><a style="color:#FFFFFF" data-sign="IG4-H5205">Protocol</a></label></center></div></div><div class="clear"></div><h3 class="h3-title">Application 1: IgG Fc protein is used as isotype control to verify the specific binding of monoclonal antibody to target antigen</h3><div class="clear"></div><div class="public_img_text_box public_img_l_r layui-col-space10 "><div class="layui-col-md12" style="padding:20px;"><p style="font-weight:bold;">Mouse IgG2a Fc protein is used as an isotype control to verify the specific binding of Mouse IgG2a CD3 monoclonal antibody (Clone: OKT3) to Human CD3 protein.</p><div class="imgBox imgOpen"><img src="/static/main/images/lgG_fc/lgG_fc_10.jpg" data-category="Mouse IgG2a Fc protein"/></div><p class="imgText"><em>Human CD3 epsilon & CD3 delta Heterodimer Protein, His Tag&Tag Free (MALS verified) (Cat. No. <a style="color:#cc3536;text-decoration: underline;" href="/P3220-Human-CD3-epsilon--CD3-delta-Heterodimer-Protein-His-TagTag-Free-%28MALS-verified%29.html" target="_blank">CDD-H52W1</a>) can bind Monoclonal Anti-Human CD3 Antibody, Mouse IgG2a (Clone: OKT3), Ultra-low endotoxin (Cat. No. CDE-M120a) with a linear range of 0.2-3 ng/mL and cannot bind Mouse IgG2a Fc Protein, Tag Free (MALS verified) (Cat. No. <a style="color:#cc3536;text-decoration: underline;" href="/P703-Mouse-IgG2a-Fc-Protein-Tag-Free-%28MALS-verified%29.html" target="_blank" data-cl-id="518929932">IGA-M5207</a>).</em></p><center><label class="btn_protocol des_protocol"><a style="color:#FFFFFF" data-sign="IGA-M5207">Protocol</a></label></center></div></div><div class="clear"></div><h3 class="h3-title">Application 2: IgG Fc protein is used as an isotype control to verify the specific binding of bispecific antibody/IgG Fc fusion protein to target antigen</h3><div class="clear"></div><div class="public_img_text_box public_img_l_r layui-col-space10 "><div class="layui-col-md6" style="padding:20px;"><p style="font-weight:bold;">Human IgG1 Fc is used as an isotype control to verify the specific binding of anti-BCMA×CD3 scFv- Human IgG1 Fc Tag to Human CD3 protein.</p><div class="imgBox imgOpen"><img src="/static/main/images/lgG_fc/lgG_fc_11.jpg" data-category="FCC-H5214_SPR"/></div><p class="imgText"><em>Human CD3 epsilon & CD3 delta Heterodimer Protein, His Tag&Tag Free (MALS verified) (Cat. No. <a style="color:#cc3536;text-decoration: underline;" href="/P3220-Human-CD3-epsilon--CD3-delta-Heterodimer-Protein-His-TagTag-Free-%28MALS-verified%29.html" target="_blank">CDD-H52W1</a>) can bind anti-BCMA×CD3 scFv- Human IgG1 Fc Tag with a linear range of 0.08-3 ng/mL and cannot bind Human IgG1 Fc Protein, Tag Free (MALS verified) (Cat. No. <a style="color:#cc3536;text-decoration: underline;" href="/P263-Human-IgG1-Fc-Protein-Tag-Free-%28MALS-verified%29.html" target="_blank" data-cl-id="1587526632">FCC-H5214</a>).</em></p><center><label class="btn_protocol des_protocol"><a style="color:#FFFFFF" data-sign="FCC-H5214">Protocol</a></label></center></div><div class="layui-col-md6" style="padding: 20px;"><p style="font-weight:bold;">Human IgG1 Fc is used as an isotype control to verify the specific binding of anti-BCMA×CD3 scFv- Human IgG1 Fc Tag to Human BCMA protein.</p><div class="imgBox imgOpen"><img src="/static/main/images/lgG_fc/lgG_fc_12.jpg" data-category="IG4-H5205_SPR"/></div><p class="imgText"><em>Human BCMA / TNFRSF17 Protein,His Tag (HPLC-verified) DMF Filed (Cat. No. <a style="color:#cc3536;text-decoration: underline;" href="/P2187-Human-BCMA--TNFRSF17-ProteinHis-Tag-%28HPLC-verified%29-DMF-Filed.html" target="_blank">BCA-H522y</a>) can bind anti-BCMA×CD3 scFv- Human IgG1 Fc Tag with a linear range of 0.08-3 ng/mL and cannot bind Human IgG1 Fc Protein, Tag Free (MALS verified) (Cat. No. <a style="color:#cc3536;text-decoration: underline;" href="/P263-Human-IgG1-Fc-Protein-Tag-Free-%28MALS-verified%29.html" target="_blank" data-cl-id="1587526632">FCC-H5214</a>).</em></p><center><label class="btn_protocol des_protocol"><a style="color:#FFFFFF" data-sign="FCC-H5214">Protocol</a></label></center></div></div><div class="clear"></div><h3 class="h3-title">Related Reading</h3><div class="clear"></div><p style="font-size: 14px; font-family: arial, helvetica, sans-serif;"><a style="color:#cc3536;text-decoration: underline;" href="/A1339-Programmable-half-life-and-anti-tumor-effects-of-Nanobody.html" target="_blank" data-cl-id="1635236142">＞＞Programmable half-life and anti-tumor effects of Nanobody</a></p><p style="font-size: 14px; font-family: arial, helvetica, sans-serif;"><a style="color:#cc3536;text-decoration: underline;" href="/A1447-Decrease-or-increase-two-therapeutic-strategies-via-FcRn-mediated-mechanism.html" target="_blank" data-cl-id="1635236142">＞＞Increase or Decrease: The Two Therapeutic Strategies via FcRn-Mediated Mechanism</a></p></div><div class="productSection" id="literature"><div class="productTit">References</div><div class="citationBox"><div class="box current"><h3><span class="yuan1"></span> <span class="yuan2"></span> Fc gamma receptors: glycobiology and therapeutic prospects</h3><ul class=" list-paddingleft-2" style="display: block;"><li><p><strong>Authors:</strong>Hayes JM, Wormald MR , Rudd PM, Davey GP</p></li><li><p><a href="https://data.acrobiosystems.cn/1-Fc%20gamma%20receptors%20glycobiology%20and%20therapeutic.pdf" class="product_citation" style="color: #FFF;" target="_blank">Download Full Article</a></p></li></ul></div></div><div class="citationBox"><div class="box current" style="margin-top: 10px"><h3><span class="yuan1"></span> <span class="yuan2"></span> How to select IgG subclasses in developing anti-tumor therapeutic antibodies</h3><ul class=" list-paddingleft-2" style="display: block;"><li><p><strong>Authors:</strong>Yu et al.</p></li><li><p><a href="https://data.acrobiosystems.cn/2-How%20to%20select%20IgG%20subclasses%20in%20developing.pdf" class="product_citation" style="color: #FFF;" target="_blank">Download Full Article</a></p></li></ul></div></div><div class="citationBox"><div class="box current" style="margin-top: 10px"><h3><span class="yuan1"></span> <span class="yuan2"></span> Fc fusion as a platform technology: potential for modulating immunogenicity</h3><ul class=" list-paddingleft-2" style="display: block;"><li><p><strong>Authors:</strong>Ditza Levin et al.</p></li><li><p><a href="https://data.acrobiosystems.cn/3-Fc%20fusion%20as%20a%20platform%20technology.pdf" class="product_citation" style="color: #FFF;" target="_blank">Download Full Article</a></p></li></ul></div></div></div></div></div><div class="keifu"><div class="footer_kf keifu_box"><div class="fd_box"><div class="fd_box01"><div class="fd_box02"><div class="fd_gb"><a 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if (!window.embedded_svc) { var s = document.createElement('script'); s.setAttribute('src', 'https://d7f000005vpftua0.my.salesforce.com/embeddedservice/5.0/esw.min.js'); s.onload = function() { initESW(null, onlineChatuserInfo); }; document.body.appendChild(s); } else { initESW('https://service.force.com', onlineChatuserInfo); } </script> <script type="text/javascript"> var loadInit = self.setInterval("loadInput()", 300); var loadInit2 = self.setInterval("loadInput2()", 300); function loadInput2() { var comdiv = document.getElementsByClassName("showDockableContainer")[0]; var sidebar = document.getElementsByClassName("sidebarBody")[0]; if (comdiv != undefined) { // 弹窗 Header var buttonElement = document.querySelector( "[c-preChatHeaderLWC_preChatHeaderLWC-host]" ); // 鼠标形状是小手 if(buttonElement != undefined){ buttonElement.style.cursor ='pointer'; } if(comdiv.style.width == "320px"){ sidebar.style.width = "318px" } var dismaxbuttonId = ''; var minbuttonId = ''; if( dismaxbuttonId == '' || minbuttonId == ''){ for(var i = 0;i < 100;i++){ var indexNo = i == 0?'1':i+'1'; if(buttonElement != undefined){ var dismaxbuttonIdf = '#utilityexpand_alt-'+indexNo; var dismaxbutton = buttonElement.shadowRoot.querySelector( dismaxbuttonIdf ); if(dismaxbutton != undefined){ dismaxbuttonId = dismaxbuttonIdf } var minbuttonIdf = '#utilitycontract_alt-'+indexNo; var disminbutton = buttonElement.shadowRoot.querySelector( minbuttonIdf ); if(disminbutton != undefined){ minbuttonId = minbuttonIdf } } } } if( dismaxbuttonId == '' || minbuttonId == ''){ for(var i = 0;i < 100;i++){ for(var j = 0;j < 100;j++){ var indexNo = i+ ''+ j; if(buttonElement != undefined){ var dismaxbuttonIdf = '#utilityexpand_alt-'+indexNo; var dismaxbutton = buttonElement.shadowRoot.querySelector( dismaxbuttonIdf ); if(dismaxbutton != undefined){ dismaxbuttonId = dismaxbuttonIdf } var minbuttonIdf = '#utilitycontract_alt-'+indexNo; var disminbutton = buttonElement.shadowRoot.querySelector( minbuttonIdf ); if(disminbutton != undefined){ minbuttonId = minbuttonIdf } } } } } var maxbutton ; var dismaxbutton; var minbutton ; var disminbutton; var minbutton2; var closebutton; if(buttonElement != undefined){ //最大化按钮 maxbutton = buttonElement.shadowRoot.querySelector( 'lightning-icon[class="slds-icon-utility-expand-alt slds-icon_container"]' ); // 隐藏最大化按钮 dismaxbutton = buttonElement.shadowRoot.querySelector( dismaxbuttonId ); //还原按钮 minbutton = buttonElement.shadowRoot.querySelector( 'lightning-icon[class="slds-icon-utility-contract-alt slds-icon_container"]' ); // 隐藏还原按钮 disminbutton = buttonElement.shadowRoot.querySelector( minbuttonId ); // 最小化按钮 minbutton2 = buttonElement.shadowRoot.querySelector( 'lightning-icon[class="slds-icon-utility-minimize-window slds-icon_container"]' ); // 关闭按钮 closebutton = buttonElement.shadowRoot.querySelector( 'lightning-icon[class="slds-icon-utility-close slds-icon_container"]' ); } //最大化 if (maxbutton != undefined) { // 隐藏最大化图标 if(comdiv.style.height != "100vh" ){ disminbutton.style.display= 'none'; dismaxbutton.style.display= 'block'; } // 保留最大化前弹窗位置 var popupLeft = comdiv.style.left; var popupRight = comdiv.style.right; var popupTop = comdiv.style.top; var popupBittom = comdiv.style.bittom; maxbutton.onclick = function () { if(dismaxbutton != undefined){ dismaxbutton.style.display= 'none'; } if(disminbutton != undefined){ disminbutton.style.display= 'block'; } // 外部弹窗大小 comdiv.style.width = "96%"; comdiv.style.left = "2%"; comdiv.style.top = "0"; comdiv.style.height = "100vh"; // 内部弹窗大小 var clientwidth = document.documentElement.clientWidth || document.body.clientWidth; sidebar.style.width = (clientwidth*0.96 -2) +'px'; sidebar.style.left = "0"; sidebar.style.top = "0"; sidebar.style.height = "100vh"; //还原 if (minbutton != undefined) { minbutton.onclick = function () { comdiv.style.left = popupLeft; comdiv.style.right = popupRight; comdiv.style.top = popupTop; comdiv.style.bittom = popupBittom; if(dismaxbutton != undefined){ dismaxbutton.style.display= 'block'; } // 隐藏还原按钮图标 if(disminbutton != undefined){ disminbutton.style.display= 'none'; } comdiv.style.width = "320px"; comdiv.style.height = "498px"; sidebar.style.width = "318px"; sidebar.style.height = "498px"; clearInterval(loadInit2); }; } else { clearInterval(loadInit2); } }; } if(minbutton2 != undefined){ minbutton2.onclick = function () { dismaxbutton.style.display= 'block'; disminbutton.style.display= 'none'; } } if(closebutton != undefined){ closebutton.onclick = function () { dismaxbutton.style.display= 'block'; disminbutton.style.display= 'none'; } } loadInput(); // 弹窗移动 if(buttonElement != undefined){ buttonElement.onmousedown = function (e) { //spaceX鼠标在登录弹窗中，距离左边框的左偏移量 var spaceX = e.clientX - comdiv.offsetLeft; //spaceY鼠标在登录弹窗中，距离上边框的上偏移量 var spaceY = e.clientY - comdiv.offsetTop; //按下login_title区域，为整个网页文档注册鼠标移动事件 document.onmousemove = function (e) { if(comdiv.style.width == "320px"){ sidebar.style.width = "318px" } var clientHeight = document.documentElement.clientHeight || document.body.clientHeight; var clientwidth = document.documentElement.clientWidth || document.body.clientWidth; var x = e.clientX - spaceX; // 移动弹窗时左右限制 if(x <0){ x=0; } else if(x > clientwidth - comdiv.offsetWidth){ x = clientwidth - comdiv.offsetWidth; } // 移动弹窗时上下限制 var y = e.clientY - spaceY; if(y <0){ y=0; } else if(y >clientHeight -comdiv.offsetHeight){ y = clientHeight -comdiv.offsetHeight; } comdiv.style.left = x + "px"; comdiv.style.top = y + "px"; }; e.preventDefault(); }; //松开下login_title区域，为整个网页文档解绑鼠标移动事件 buttonElement.onmouseup = function (evn) { evn.preventDefault(); buttonElement.onmousemove = null; document.onmousemove = null; }; } } if(comdiv != undefined){ // 定义4个变量 var disX = 0;//鼠标按下时光标的X值 var disY = 0;//鼠标按下时光标的Y值 var disW = 0; //拖拽前div的宽 var disH = 0; // 拖拽前div的高 //3. 给小div加点击事件 comdiv.onmouseover = function (evs) { var evs = evs || window.event; var offsetLeft = comdiv.offsetLeft; var getfoc = Math.abs(evs.clientX - (parseInt(offsetLeft)+comdiv.offsetWidth)); console.log('getfoc====>'+getfoc); if( getfoc == 1 || getfoc == 2 ){ comdiv.style.cursor ='col-resize'; document.onmousedown = function (ev) { var ev = ev || window.event; disX = ev.clientX; // 获取鼠标按下时光标x的值 disY = ev.clientY; // 获取鼠标按下时光标Y的值 if(sidebar != undefined){ disW = sidebar.offsetWidth; // 获取拖拽前div的宽 disH = sidebar.offsetHeight; // 获取拖拽前div的高 } document.onmousemove = function (evm) { var clientHeight = document.documentElement.clientHeight || document.body.clientHeight; var clientwidth = document.documentElement.clientWidth || document.body.clientWidth; console.log('clientwidth===>'+clientwidth); var evm = evm || window.event; //拖拽时为了对宽和高限制一下范围，定义两个变量 var W = evm.clientX - disX + disW; var H = evm.clientY - disY + disH; if (W < 320) { W = 320; } else if (W > clientwidth-40 ){ W = clientwidth-40 ; } if (H < 498) { H = 498; } else if (H > clientHeight ){ H = clientHeight ; } if(sidebar != undefined){ sidebar.style.width = (W-2) + 'px';// 拖拽后物体的宽 sidebar.style.height = H + 'px';// 拖拽后物体的高 } if(comdiv != undefined){ comdiv.style.width = W + 'px';// 拖拽后物体的宽 comdiv.style.height = H + 'px';// 拖拽后物体的高 } evm.preventDefault(); } document.onmouseup = function (evn) { var evn = evn || window.event; 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