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data-dom-id="ProfileCheckPaperUpdate-react-component-36926dd6-0786-4df9-a9de-b0d7d96a2c91"></div> <div id="ProfileCheckPaperUpdate-react-component-36926dd6-0786-4df9-a9de-b0d7d96a2c91"></div> <div class="DesignSystem"><div class="onsite-ping" id="onsite-ping"></div></div><div class="profile-user-info DesignSystem"><div class="social-profile-container"><div class="left-panel-container"><div class="user-info-component-wrapper"><div class="user-summary-cta-container"><div class="user-summary-container"><div class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">Cinzia Lucchesi</h1><div class="affiliations-container fake-truncate js-profile-affiliations"><div><a class="u-tcGrayDarker" href="https://pisa.academia.edu/">University of Pisa</a>, <a class="u-tcGrayDarker" href="https://pisa.academia.edu/Departments/Clinical_and_experimental_medicine/Documents">Clinical and experimental medicine</a>, <span class="u-tcGrayDarker">Department Member</span></div></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" data-broccoli-component="user-info.follow-button" data-click-track="profile-user-info-follow-button" data-follow-user-fname="Cinzia" data-follow-user-id="32903902" data-follow-user-source="profile_button" data-has-google="false"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">add</span>Follow</button><button class="ds2-5-button hidden profile-cta-button grow js-profile-unfollow-button" data-broccoli-component="user-info.unfollow-button" data-click-track="profile-user-info-unfollow-button" data-unfollow-user-id="32903902"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">done</span>Following</button></div></div><div class="user-stats-container"><a><div class="stat-container js-profile-followers"><p class="label">Followers</p><p class="data">6</p></div></a><a><div class="stat-container js-profile-followees" data-broccoli-component="user-info.followees-count" data-click-track="profile-expand-user-info-following"><p class="label">Following</p><p class="data">5</p></div></a><a><div class="stat-container js-profile-coauthors" data-broccoli-component="user-info.coauthors-count" data-click-track="profile-expand-user-info-coauthors"><p class="label">Co-authors</p><p class="data">6</p></div></a><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a 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href="https://www.academia.edu/Documents/in/Biomarkers"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Biomarkers"]}" data-trace="false" data-dom-id="Pill-react-component-671a0883-a085-4993-afb1-2ce0b0e3aa26"></div> <div id="Pill-react-component-671a0883-a085-4993-afb1-2ce0b0e3aa26"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="32903902" href="https://www.academia.edu/Documents/in/Biomedical_signal_and_image_processing"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Biomedical signal and image processing"]}" data-trace="false" data-dom-id="Pill-react-component-af3f6dd0-3fdf-4825-a18c-45f235ba0e25"></div> <div id="Pill-react-component-af3f6dd0-3fdf-4825-a18c-45f235ba0e25"></div> </a><a data-click-track="profile-user-info-expand-research-interests" 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class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Cinzia Lucchesi</h3></div><div class="js-work-strip profile--work_container" data-work-id="13807948"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/13807948/Almotriptan_Review_of_Efficacy_in_Treating_Migraine_in_Adolescents"><img alt="Research paper thumbnail of Almotriptan: Review of Efficacy in Treating Migraine in Adolescents" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/13807948/Almotriptan_Review_of_Efficacy_in_Treating_Migraine_in_Adolescents">Almotriptan: Review of Efficacy in Treating Migraine in Adolescents</a></div><div class="wp-workCard_item"><span>Clinical Medicine Reviews in Therapeutics</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13807948"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13807948"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13807948; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13807948]").text(description); $(".js-view-count[data-work-id=13807948]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13807948; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13807948']"); 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$a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13807937"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13807937/Fatigue_Is_Increased_in_Episodic_Migraine_Without_Aura_Patients"><img alt="Research paper thumbnail of Fatigue Is Increased in Episodic Migraine Without Aura Patients" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13807937/Fatigue_Is_Increased_in_Episodic_Migraine_Without_Aura_Patients">Fatigue Is Increased in Episodic Migraine Without Aura Patients</a></div><div class="wp-workCard_item"><span>Headache: The Journal of Head and Face Pain</span><span>, 2013</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13807937"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13807937"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13807937; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 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href="https://www.academia.edu/13807928/Occipital_neuralgia_a_symptomatic_case_caused_by_an_abnormal_left_vertebral_artery"><img alt="Research paper thumbnail of Occipital neuralgia: a symptomatic case caused by an abnormal left vertebral artery" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13807928/Occipital_neuralgia_a_symptomatic_case_caused_by_an_abnormal_left_vertebral_artery">Occipital neuralgia: a symptomatic case caused by an abnormal left vertebral artery</a></div><div class="wp-workCard_item"><span>Neurological Sciences</span><span>, 2013</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action 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class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13802030/Preferential_occurrence_of_attacks_during_night_sleep_and_or_upon_awakening_negatively_affects_migraine_clinical_presentation"><img alt="Research paper thumbnail of Preferential occurrence of attacks during night sleep and/or upon awakening negatively affects migraine clinical presentation" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13802030/Preferential_occurrence_of_attacks_during_night_sleep_and_or_upon_awakening_negatively_affects_migraine_clinical_presentation">Preferential occurrence of attacks during night sleep and/or upon awakening negatively affects migraine clinical presentation</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://pisa.academia.edu/CinziaLucchesi">Cinzia Lucchesi</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FilippoBaldacci">Filippo Baldacci</a></span></div><div class="wp-workCard_item"><span>Functional neurology</span><span>, Jan 26, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">It is well known that migraine attacks can preferentially occur during night sleep and/or upon aw...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">It is well known that migraine attacks can preferentially occur during night sleep and/or upon awakening, however the possible implications of this timing on migraine clinical presentation remain unclear. The aim of this study was to assess the possible consequences of sleep-related migraine (defined as ≥75% of migraine attacks occurring during night sleep and/or upon awakening) on the migraine clinical picture (i.e. migraine-related disability, attack severity, use of symptomatic drugs), subjective sleep quality, excessive daytime sleepiness and fatigue. Two hundred consecutive migraine without aura patients were enrolled; patients with comorbid disorders or chronic medication use were excluded. 39% of the migraineurs included in the study received a diagnosis of sleep-related migraine. The mean frequency of migraine attacks (days per month) did not significantly differ between the patients with and those without sleep-related migraine, whereas migraine-related disability (p&lt;0.0...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13802030"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13802030"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13802030; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13802030]").text(description); $(".js-view-count[data-work-id=13802030]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13802030; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13802030']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13802030, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=13802030]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13802030,"title":"Preferential occurrence of attacks during night sleep and/or upon awakening negatively affects migraine clinical presentation","translated_title":"","metadata":{"abstract":"It is well known that migraine attacks can preferentially occur during night sleep and/or upon awakening, however the possible implications of this timing on migraine clinical presentation remain unclear. The aim of this study was to assess the possible consequences of sleep-related migraine (defined as ≥75% of migraine attacks occurring during night sleep and/or upon awakening) on the migraine clinical picture (i.e. migraine-related disability, attack severity, use of symptomatic drugs), subjective sleep quality, excessive daytime sleepiness and fatigue. Two hundred consecutive migraine without aura patients were enrolled; patients with comorbid disorders or chronic medication use were excluded. 39% of the migraineurs included in the study received a diagnosis of sleep-related migraine. The mean frequency of migraine attacks (days per month) did not significantly differ between the patients with and those without sleep-related migraine, whereas migraine-related disability (p\u0026lt;0.0...","publication_date":{"day":26,"month":1,"year":2015,"errors":{}},"publication_name":"Functional neurology"},"translated_abstract":"It is well known that migraine attacks can preferentially occur during night sleep and/or upon awakening, however the possible implications of this timing on migraine clinical presentation remain unclear. The aim of this study was to assess the possible consequences of sleep-related migraine (defined as ≥75% of migraine attacks occurring during night sleep and/or upon awakening) on the migraine clinical picture (i.e. migraine-related disability, attack severity, use of symptomatic drugs), subjective sleep quality, excessive daytime sleepiness and fatigue. Two hundred consecutive migraine without aura patients were enrolled; patients with comorbid disorders or chronic medication use were excluded. 39% of the migraineurs included in the study received a diagnosis of sleep-related migraine. The mean frequency of migraine attacks (days per month) did not significantly differ between the patients with and those without sleep-related migraine, whereas migraine-related disability (p\u0026lt;0.0...","internal_url":"https://www.academia.edu/13802030/Preferential_occurrence_of_attacks_during_night_sleep_and_or_upon_awakening_negatively_affects_migraine_clinical_presentation","translated_internal_url":"","created_at":"2015-07-08T08:42:28.049-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32903902,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":2637535,"work_id":13802030,"tagging_user_id":32903902,"tagged_user_id":32737123,"co_author_invite_id":null,"email":"f***i@unipi.it","display_order":0,"name":"Filippo Baldacci","title":"Preferential occurrence of attacks during night sleep and/or upon awakening negatively affects migraine clinical presentation"},{"id":2637546,"work_id":13802030,"tagging_user_id":32903902,"tagged_user_id":26135594,"co_author_invite_id":null,"email":"u***i@med.unipi.it","affiliation":"University of Pisa","display_order":4194304,"name":"Ubaldo Bonuccelli","title":"Preferential occurrence of attacks during night sleep and/or upon awakening negatively affects migraine clinical presentation"}],"downloadable_attachments":[],"slug":"Preferential_occurrence_of_attacks_during_night_sleep_and_or_upon_awakening_negatively_affects_migraine_clinical_presentation","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":32903902,"first_name":"Cinzia","middle_initials":null,"last_name":"Lucchesi","page_name":"CinziaLucchesi","domain_name":"pisa","created_at":"2015-07-08T08:41:47.730-07:00","display_name":"Cinzia Lucchesi","url":"https://pisa.academia.edu/CinziaLucchesi"},"attachments":[],"research_interests":[{"id":327959,"name":"Functional Neurology","url":"https://www.academia.edu/Documents/in/Functional_Neurology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13802029"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13802029/Evidences_of_Reduced_Antioxidant_Activity_in_Patients_With_Chronic_Migraine_and_Medication_Overuse_Headache"><img alt="Research paper thumbnail of Evidences of Reduced Antioxidant Activity in Patients With Chronic Migraine and Medication-Overuse Headache" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13802029/Evidences_of_Reduced_Antioxidant_Activity_in_Patients_With_Chronic_Migraine_and_Medication_Overuse_Headache">Evidences of Reduced Antioxidant Activity in Patients With Chronic Migraine and Medication-Overuse Headache</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://pisa.academia.edu/CinziaLucchesi">Cinzia Lucchesi</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FilippoBaldacci">Filippo Baldacci</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/GerstnerO">Gerstner O</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/AnnalisaLogerfo">Annalisa Logerfo</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/LuciaChico">Lucia Chico</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://pisa.academia.edu/MartinaCafalli">Martina Cafalli</a></span></div><div class="wp-workCard_item"><span>Headache</span><span>, Jan 30, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Migraine is a complex multifactorial, neurobiological disorder, whose pathogenesis is not fully u...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Migraine is a complex multifactorial, neurobiological disorder, whose pathogenesis is not fully understood, nor are the mechanisms associated with migraine transformation from episodic to chronic pattern. A possible role of impaired oxidative mitochondrial metabolism in migraine pathogenesis has been hypothesized, and increased levels of peripheral markers of oxidative stress have been reported in migraine patients, although the literature data are limited and heterogeneous. The aim of this cross-sectional study was to determine plasmatic levels of advanced oxidation protein products, ferric-reducing antioxidant power and total plasmatic thiol groups, all plasmatic markers related to oxidative stress, in a sample of chronic migraine patients and medication-overuse headache, compared to a control group of healthy subjects. Thirty-three patients with a diagnosis of both chronic migraine and medication-overuse headache (International Classification of Headache Disorders,3rd edition, be...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13802029"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13802029"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13802029; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13802029]").text(description); $(".js-view-count[data-work-id=13802029]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13802029; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13802029']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13802029, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=13802029]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13802029,"title":"Evidences of Reduced Antioxidant Activity in Patients With Chronic Migraine and Medication-Overuse Headache","translated_title":"","metadata":{"abstract":"Migraine is a complex multifactorial, neurobiological disorder, whose pathogenesis is not fully understood, nor are the mechanisms associated with migraine transformation from episodic to chronic pattern. 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Thirty-three patients with a diagnosis of both chronic migraine and medication-overuse headache (International Classification of Headache Disorders,3rd edition, be...","publication_date":{"day":30,"month":1,"year":2015,"errors":{}},"publication_name":"Headache"},"translated_abstract":"Migraine is a complex multifactorial, neurobiological disorder, whose pathogenesis is not fully understood, nor are the mechanisms associated with migraine transformation from episodic to chronic pattern. A possible role of impaired oxidative mitochondrial metabolism in migraine pathogenesis has been hypothesized, and increased levels of peripheral markers of oxidative stress have been reported in migraine patients, although the literature data are limited and heterogeneous. The aim of this cross-sectional study was to determine plasmatic levels of advanced oxidation protein products, ferric-reducing antioxidant power and total plasmatic thiol groups, all plasmatic markers related to oxidative stress, in a sample of chronic migraine patients and medication-overuse headache, compared to a control group of healthy subjects. Thirty-three patients with a diagnosis of both chronic migraine and medication-overuse headache (International Classification of Headache Disorders,3rd edition, be...","internal_url":"https://www.academia.edu/13802029/Evidences_of_Reduced_Antioxidant_Activity_in_Patients_With_Chronic_Migraine_and_Medication_Overuse_Headache","translated_internal_url":"","created_at":"2015-07-08T08:42:27.919-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32903902,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":2637536,"work_id":13802029,"tagging_user_id":32903902,"tagged_user_id":32737123,"co_author_invite_id":null,"email":"f***i@unipi.it","display_order":0,"name":"Filippo Baldacci","title":"Evidences of Reduced Antioxidant Activity in Patients With Chronic Migraine and Medication-Overuse Headache"},{"id":2637543,"work_id":13802029,"tagging_user_id":32903902,"tagged_user_id":32969979,"co_author_invite_id":377941,"email":"g***o@med.unipi.it","display_order":4194304,"name":"Gerstner O","title":"Evidences of Reduced Antioxidant Activity in Patients With Chronic Migraine and Medication-Overuse Headache"},{"id":2637547,"work_id":13802029,"tagging_user_id":32903902,"tagged_user_id":26135594,"co_author_invite_id":null,"email":"u***i@med.unipi.it","affiliation":"University of Pisa","display_order":6291456,"name":"Ubaldo Bonuccelli","title":"Evidences of Reduced Antioxidant Activity in Patients With Chronic Migraine and Medication-Overuse Headache"},{"id":20414882,"work_id":13802029,"tagging_user_id":32737123,"tagged_user_id":31933113,"co_author_invite_id":null,"email":"g***a@neuro.med.unipi.it","affiliation":"University of Pisa","display_order":7340032,"name":"G. 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A &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;am...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Migraine, anxiety and depression often coexist. A &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;neurolimbic&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; model of migraine has been recently proposed accounting for a dynamic influence of pain, mood and anxiety on the migraine disease. However, very few data exist concerning clinical migraine features in patients reporting anxiety-depression symptoms. Aim of our study was to test differences in clinical migraine features between migraineurs with anxiety-depression symptoms and migraineurs without ones. We recruited 200 consecutive migraineurs. Other primary headaches comorbidity and migraine prophylaxis were exclusion criteria. Each patient was interviewed following a structured questionnaire including general features about migraine, triggers, allodynia. Anxiety and depression symptoms were evaluated in each patient by two brief self-reported scales: the generalized anxiety disorder 7-item scale (GAD-7) and the Patient Health Questionnaire 9-item scale (PHQ-9). A cut-off of 5 in both the GAD-7 and the PHQ-9 was considered positive for the presence of anxiety-depressive symptoms. One hundred and one patients (51.5%) had anxiety-depression symptoms (GAD-7 and PHQ-9≥5). They reported a more headaches/month (p=0.004), higher number of triggers (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001), and were more allodynic (p=0.005). In a binary logistic regression model triggers and allodynia made a unique statistical contribution on reporting anxiety-depression symptoms. Our results showed that the presence of anxiety-depression symptoms affects migraine clinical presentation. They are associated with enhanced migraine triggers susceptibility, more ictal allodynic symptoms as well as more headaches/month. An altered sensation in migraineurs with anxiety-depression symptoms could be a result of a lower pain threshold and an increased cortical excitability in a broader context of a neurolimbic dysfunction.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13802028"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13802028"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13802028; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13802028]").text(description); $(".js-view-count[data-work-id=13802028]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13802028; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13802028']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13802028, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=13802028]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13802028,"title":"Migraine features in migraineurs with and without anxiety-depression symptoms: a hospital-based study","translated_title":"","metadata":{"abstract":"Migraine, anxiety and depression often coexist. A \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;neurolimbic\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; model of migraine has been recently proposed accounting for a dynamic influence of pain, mood and anxiety on the migraine disease. However, very few data exist concerning clinical migraine features in patients reporting anxiety-depression symptoms. Aim of our study was to test differences in clinical migraine features between migraineurs with anxiety-depression symptoms and migraineurs without ones. We recruited 200 consecutive migraineurs. Other primary headaches comorbidity and migraine prophylaxis were exclusion criteria. Each patient was interviewed following a structured questionnaire including general features about migraine, triggers, allodynia. Anxiety and depression symptoms were evaluated in each patient by two brief self-reported scales: the generalized anxiety disorder 7-item scale (GAD-7) and the Patient Health Questionnaire 9-item scale (PHQ-9). A cut-off of 5 in both the GAD-7 and the PHQ-9 was considered positive for the presence of anxiety-depressive symptoms. One hundred and one patients (51.5%) had anxiety-depression symptoms (GAD-7 and PHQ-9≥5). They reported a more headaches/month (p=0.004), higher number of triggers (p\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001), and were more allodynic (p=0.005). In a binary logistic regression model triggers and allodynia made a unique statistical contribution on reporting anxiety-depression symptoms. Our results showed that the presence of anxiety-depression symptoms affects migraine clinical presentation. They are associated with enhanced migraine triggers susceptibility, more ictal allodynic symptoms as well as more headaches/month. An altered sensation in migraineurs with anxiety-depression symptoms could be a result of a lower pain threshold and an increased cortical excitability in a broader context of a neurolimbic dysfunction.","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Clinical Neurology and Neurosurgery"},"translated_abstract":"Migraine, anxiety and depression often coexist. A \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;neurolimbic\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; model of migraine has been recently proposed accounting for a dynamic influence of pain, mood and anxiety on the migraine disease. However, very few data exist concerning clinical migraine features in patients reporting anxiety-depression symptoms. Aim of our study was to test differences in clinical migraine features between migraineurs with anxiety-depression symptoms and migraineurs without ones. We recruited 200 consecutive migraineurs. Other primary headaches comorbidity and migraine prophylaxis were exclusion criteria. Each patient was interviewed following a structured questionnaire including general features about migraine, triggers, allodynia. Anxiety and depression symptoms were evaluated in each patient by two brief self-reported scales: the generalized anxiety disorder 7-item scale (GAD-7) and the Patient Health Questionnaire 9-item scale (PHQ-9). A cut-off of 5 in both the GAD-7 and the PHQ-9 was considered positive for the presence of anxiety-depressive symptoms. One hundred and one patients (51.5%) had anxiety-depression symptoms (GAD-7 and PHQ-9≥5). They reported a more headaches/month (p=0.004), higher number of triggers (p\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001), and were more allodynic (p=0.005). In a binary logistic regression model triggers and allodynia made a unique statistical contribution on reporting anxiety-depression symptoms. Our results showed that the presence of anxiety-depression symptoms affects migraine clinical presentation. They are associated with enhanced migraine triggers susceptibility, more ictal allodynic symptoms as well as more headaches/month. An altered sensation in migraineurs with anxiety-depression symptoms could be a result of a lower pain threshold and an increased cortical excitability in a broader context of a neurolimbic dysfunction.","internal_url":"https://www.academia.edu/13802028/Migraine_features_in_migraineurs_with_and_without_anxiety_depression_symptoms_a_hospital_based_study","translated_internal_url":"","created_at":"2015-07-08T08:42:27.795-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32903902,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":2637534,"work_id":13802028,"tagging_user_id":32903902,"tagged_user_id":32737123,"co_author_invite_id":null,"email":"f***i@unipi.it","display_order":0,"name":"Filippo Baldacci","title":"Migraine features in migraineurs with and without anxiety-depression symptoms: a hospital-based study"},{"id":2637539,"work_id":13802028,"tagging_user_id":32903902,"tagged_user_id":32895619,"co_author_invite_id":null,"email":"m***2@ausl.re.it","display_order":4194304,"name":"Michele Poletti","title":"Migraine features in migraineurs with and without anxiety-depression symptoms: a hospital-based study"},{"id":2637553,"work_id":13802028,"tagging_user_id":32903902,"tagged_user_id":32673062,"co_author_invite_id":null,"email":"m***o@gmail.com","display_order":6291456,"name":"M. Vedovello","title":"Migraine features in migraineurs with and without anxiety-depression symptoms: a hospital-based study"}],"downloadable_attachments":[],"slug":"Migraine_features_in_migraineurs_with_and_without_anxiety_depression_symptoms_a_hospital_based_study","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":32903902,"first_name":"Cinzia","middle_initials":null,"last_name":"Lucchesi","page_name":"CinziaLucchesi","domain_name":"pisa","created_at":"2015-07-08T08:41:47.730-07:00","display_name":"Cinzia Lucchesi","url":"https://pisa.academia.edu/CinziaLucchesi"},"attachments":[],"research_interests":[{"id":3217,"name":"Depression","url":"https://www.academia.edu/Documents/in/Depression"},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent"},{"id":28973,"name":"Comorbidity","url":"https://www.academia.edu/Documents/in/Comorbidity"},{"id":38676,"name":"Anxiety","url":"https://www.academia.edu/Documents/in/Anxiety"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":623821,"name":"ANXIETY","url":"https://www.academia.edu/Documents/in/ANXIETY-1"},{"id":1034181,"name":"Cross Sectional Studies","url":"https://www.academia.edu/Documents/in/Cross_Sectional_Studies"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1262481,"name":"Pain Measurement","url":"https://www.academia.edu/Documents/in/Pain_Measurement"},{"id":1446320,"name":"Hyperalgesia","url":"https://www.academia.edu/Documents/in/Hyperalgesia"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13802027"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13802027/Clinical_features_associated_with_ictal_osmophobia_in_migraine"><img alt="Research paper thumbnail of Clinical features associated with ictal osmophobia in migraine" class="work-thumbnail" src="https://attachments.academia-assets.com/44934596/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13802027/Clinical_features_associated_with_ictal_osmophobia_in_migraine">Clinical features associated with ictal osmophobia in migraine</a></div><div class="wp-workCard_item"><span>Neurological Sciences</span><span>, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8e0139e35eb715b4e44967e865876a7f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44934596,"asset_id":13802027,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44934596/download_file?st=MTczMjk5NjI2NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13802027"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13802027"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13802027; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8e0139e35eb715b4e44967e865876a7f" } } $('.js-work-strip[data-work-id=13802027]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13802027,"title":"Clinical features associated with ictal osmophobia in migraine","translated_title":"","metadata":{"grobid_abstract":"Olfactory hypersensitivity may occur during migraine attacks and has been found to be very specific for this form of headache. Aim of this study was to investigate if migraineurs with ictal osmophobia have particular clinical features comparing to patients without ictal osmophobia. We recruited 200 consecutive migraineurs. Other primary headaches comorbidity and migraine prophylaxis were exclusion criteria. Each patient was interviewed following a structured questionnaire including general features about migraine, depression and anxiety symptoms. Migraine triggers both spontaneously and selecting from a specific list. Allodynia during the migraine attack was measured using the Allodynia symptoms check-list 12 (ASC-12). Eighty four (42 %) patients are non-osmophobic vs. 116 patients (58 %) who are osmophobic. After a logistic regression analysis, pain intensity (OR 1.391; p = 0.008) and anxiety (OR 1.099; p = 0.047) were significantly higher while aura (OR 0.421; p = 0.028) is less frequent in osmophobic migraineurs. We found significant differences in clinical features of osmophobic patients in respect to non-osmophobic ones. Ictal osmophobia seems being related to a broader sensorial hypersensitivity that could lead to a more florid clinical presentation.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Neurological Sciences","grobid_abstract_attachment_id":44934596},"translated_abstract":null,"internal_url":"https://www.academia.edu/13802027/Clinical_features_associated_with_ictal_osmophobia_in_migraine","translated_internal_url":"","created_at":"2015-07-08T08:42:27.680-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32903902,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":2637533,"work_id":13802027,"tagging_user_id":32903902,"tagged_user_id":32737123,"co_author_invite_id":null,"email":"f***i@unipi.it","display_order":0,"name":"Filippo Baldacci","title":"Clinical features associated with ictal osmophobia in migraine"},{"id":2637544,"work_id":13802027,"tagging_user_id":32903902,"tagged_user_id":26135594,"co_author_invite_id":null,"email":"u***i@med.unipi.it","affiliation":"University of Pisa","display_order":4194304,"name":"Ubaldo Bonuccelli","title":"Clinical features associated with ictal osmophobia in migraine"},{"id":2637552,"work_id":13802027,"tagging_user_id":32903902,"tagged_user_id":32673062,"co_author_invite_id":null,"email":"m***o@gmail.com","display_order":6291456,"name":"M. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13802026"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13802026/Chronic_inflammatory_demyelinating_polyradiculoneuropathy_with_cranial_nerves_hypertrophy_thyroid_related_orbitopathy_and_IgG_monoclonal_gammopathy_a_case_report"><img alt="Research paper thumbnail of Chronic inflammatory demyelinating polyradiculoneuropathy with cranial nerves hypertrophy, thyroid-related orbitopathy and IgG monoclonal gammopathy: a case report" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13802026/Chronic_inflammatory_demyelinating_polyradiculoneuropathy_with_cranial_nerves_hypertrophy_thyroid_related_orbitopathy_and_IgG_monoclonal_gammopathy_a_case_report">Chronic inflammatory demyelinating polyradiculoneuropathy with cranial nerves hypertrophy, thyroid-related orbitopathy and IgG monoclonal gammopathy: a case report</a></div><div class="wp-workCard_item"><span>Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology</span><span>, Jan 3, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13802026"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13802026"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13802026; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13802023"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13802023/Sleep_related_migraine_occurrence_increases_with_aging"><img alt="Research paper thumbnail of Sleep-related migraine occurrence increases with aging" class="work-thumbnail" src="https://attachments.academia-assets.com/44934594/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13802023/Sleep_related_migraine_occurrence_increases_with_aging">Sleep-related migraine occurrence increases with aging</a></div><div class="wp-workCard_item"><span>Acta Neurologica Belgica</span><span>, 2012</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="89cff28e5d03928189954bfd6a5140b6" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44934594,"asset_id":13802023,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44934594/download_file?st=MTczMjk5NjI2NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13802023"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13802023"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13802023; 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The objective of this study was to verify the occurrence of sleep-related migraine in a large sample of migraineurs divided in different age groups and to evaluate the possible role of physiological variables (i.e., aging, gender) and comorbidities (i.e., psychiatric diseases). 734 patients (519 women and 215 males), aged 21-70 years, fulfilling IHS criteria (2004) for migraine without aura, were enrolled. The population was divided into five groups according to decades of life and it was evaluated the percentage of sleep-related migraine (at least 75% migraine attacks occurring during night sleep and/or upon awakening) in the different age groups. Headache clinical diary, Pittsburgh Sleep Quality Index and Beck Depression Inventory were also used. The preferential emergence of attacks during night sleep and/or upon awakening progressively increased with aging, without gender predilection; the percentage of patients with sleep-related migraine was: 16% between 20 and 30 years, 27% between 31 and 40 years, 38% between 41 and 50 years, 45% between 51 and 60 years, and 58% between 61 and 70 years, respectively. Poor sleep quality and depression did not account for night-time and/or awakening migraine collocation. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13582030"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13582030/Plasmatic_oxidative_stress_biomarkers_in_multiple_sclerosis_Relation_with_clinical_and_demographic_characteristics"><img alt="Research paper thumbnail of Plasmatic oxidative stress biomarkers in multiple sclerosis: Relation with clinical and demographic characteristics" class="work-thumbnail" src="https://attachments.academia-assets.com/45187761/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13582030/Plasmatic_oxidative_stress_biomarkers_in_multiple_sclerosis_Relation_with_clinical_and_demographic_characteristics">Plasmatic oxidative stress biomarkers in multiple sclerosis: Relation with clinical and demographic characteristics</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/AlfonsoIudice">Alfonso Iudice</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://pisa.academia.edu/CinziaLucchesi">Cinzia Lucchesi</a></span></div><div class="wp-workCard_item"><span>Clinical Biochemistry</span><span>, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f493fa877446999d00ce08b73349f5c1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":45187761,"asset_id":13582030,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/45187761/download_file?st=MTczMjk5NjI2NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13582030"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13582030"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13582030; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13802030"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13802030/Preferential_occurrence_of_attacks_during_night_sleep_and_or_upon_awakening_negatively_affects_migraine_clinical_presentation"><img alt="Research paper thumbnail of Preferential occurrence of attacks during night sleep and/or upon awakening negatively affects migraine clinical presentation" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13802030/Preferential_occurrence_of_attacks_during_night_sleep_and_or_upon_awakening_negatively_affects_migraine_clinical_presentation">Preferential occurrence of attacks during night sleep and/or upon awakening negatively affects migraine clinical presentation</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://pisa.academia.edu/CinziaLucchesi">Cinzia Lucchesi</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FilippoBaldacci">Filippo Baldacci</a></span></div><div class="wp-workCard_item"><span>Functional neurology</span><span>, Jan 26, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">It is well known that migraine attacks can preferentially occur during night sleep and/or upon aw...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">It is well known that migraine attacks can preferentially occur during night sleep and/or upon awakening, however the possible implications of this timing on migraine clinical presentation remain unclear. The aim of this study was to assess the possible consequences of sleep-related migraine (defined as ≥75% of migraine attacks occurring during night sleep and/or upon awakening) on the migraine clinical picture (i.e. migraine-related disability, attack severity, use of symptomatic drugs), subjective sleep quality, excessive daytime sleepiness and fatigue. Two hundred consecutive migraine without aura patients were enrolled; patients with comorbid disorders or chronic medication use were excluded. 39% of the migraineurs included in the study received a diagnosis of sleep-related migraine. The mean frequency of migraine attacks (days per month) did not significantly differ between the patients with and those without sleep-related migraine, whereas migraine-related disability (p&lt;0.0...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13802030"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13802030"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13802030; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13802030]").text(description); $(".js-view-count[data-work-id=13802030]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13802030; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13802030']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13802030, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=13802030]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13802030,"title":"Preferential occurrence of attacks during night sleep and/or upon awakening negatively affects migraine clinical presentation","translated_title":"","metadata":{"abstract":"It is well known that migraine attacks can preferentially occur during night sleep and/or upon awakening, however the possible implications of this timing on migraine clinical presentation remain unclear. 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The mean frequency of migraine attacks (days per month) did not significantly differ between the patients with and those without sleep-related migraine, whereas migraine-related disability (p\u0026lt;0.0...","publication_date":{"day":26,"month":1,"year":2015,"errors":{}},"publication_name":"Functional neurology"},"translated_abstract":"It is well known that migraine attacks can preferentially occur during night sleep and/or upon awakening, however the possible implications of this timing on migraine clinical presentation remain unclear. The aim of this study was to assess the possible consequences of sleep-related migraine (defined as ≥75% of migraine attacks occurring during night sleep and/or upon awakening) on the migraine clinical picture (i.e. migraine-related disability, attack severity, use of symptomatic drugs), subjective sleep quality, excessive daytime sleepiness and fatigue. Two hundred consecutive migraine without aura patients were enrolled; patients with comorbid disorders or chronic medication use were excluded. 39% of the migraineurs included in the study received a diagnosis of sleep-related migraine. The mean frequency of migraine attacks (days per month) did not significantly differ between the patients with and those without sleep-related migraine, whereas migraine-related disability (p\u0026lt;0.0...","internal_url":"https://www.academia.edu/13802030/Preferential_occurrence_of_attacks_during_night_sleep_and_or_upon_awakening_negatively_affects_migraine_clinical_presentation","translated_internal_url":"","created_at":"2015-07-08T08:42:28.049-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32903902,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":2637535,"work_id":13802030,"tagging_user_id":32903902,"tagged_user_id":32737123,"co_author_invite_id":null,"email":"f***i@unipi.it","display_order":0,"name":"Filippo Baldacci","title":"Preferential occurrence of attacks during night sleep and/or upon awakening negatively affects migraine clinical presentation"},{"id":2637546,"work_id":13802030,"tagging_user_id":32903902,"tagged_user_id":26135594,"co_author_invite_id":null,"email":"u***i@med.unipi.it","affiliation":"University of Pisa","display_order":4194304,"name":"Ubaldo Bonuccelli","title":"Preferential occurrence of attacks during night sleep and/or upon awakening negatively affects migraine clinical presentation"}],"downloadable_attachments":[],"slug":"Preferential_occurrence_of_attacks_during_night_sleep_and_or_upon_awakening_negatively_affects_migraine_clinical_presentation","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":32903902,"first_name":"Cinzia","middle_initials":null,"last_name":"Lucchesi","page_name":"CinziaLucchesi","domain_name":"pisa","created_at":"2015-07-08T08:41:47.730-07:00","display_name":"Cinzia Lucchesi","url":"https://pisa.academia.edu/CinziaLucchesi"},"attachments":[],"research_interests":[{"id":327959,"name":"Functional Neurology","url":"https://www.academia.edu/Documents/in/Functional_Neurology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13802029"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13802029/Evidences_of_Reduced_Antioxidant_Activity_in_Patients_With_Chronic_Migraine_and_Medication_Overuse_Headache"><img alt="Research paper thumbnail of Evidences of Reduced Antioxidant Activity in Patients With Chronic Migraine and Medication-Overuse Headache" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13802029/Evidences_of_Reduced_Antioxidant_Activity_in_Patients_With_Chronic_Migraine_and_Medication_Overuse_Headache">Evidences of Reduced Antioxidant Activity in Patients With Chronic Migraine and Medication-Overuse Headache</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://pisa.academia.edu/CinziaLucchesi">Cinzia Lucchesi</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FilippoBaldacci">Filippo Baldacci</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/GerstnerO">Gerstner O</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/AnnalisaLogerfo">Annalisa Logerfo</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/LuciaChico">Lucia Chico</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://pisa.academia.edu/MartinaCafalli">Martina Cafalli</a></span></div><div class="wp-workCard_item"><span>Headache</span><span>, Jan 30, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Migraine is a complex multifactorial, neurobiological disorder, whose pathogenesis is not fully u...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Migraine is a complex multifactorial, neurobiological disorder, whose pathogenesis is not fully understood, nor are the mechanisms associated with migraine transformation from episodic to chronic pattern. A possible role of impaired oxidative mitochondrial metabolism in migraine pathogenesis has been hypothesized, and increased levels of peripheral markers of oxidative stress have been reported in migraine patients, although the literature data are limited and heterogeneous. The aim of this cross-sectional study was to determine plasmatic levels of advanced oxidation protein products, ferric-reducing antioxidant power and total plasmatic thiol groups, all plasmatic markers related to oxidative stress, in a sample of chronic migraine patients and medication-overuse headache, compared to a control group of healthy subjects. Thirty-three patients with a diagnosis of both chronic migraine and medication-overuse headache (International Classification of Headache Disorders,3rd edition, be...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13802029"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13802029"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13802029; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13802029]").text(description); $(".js-view-count[data-work-id=13802029]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13802029; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13802029']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13802029, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=13802029]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13802029,"title":"Evidences of Reduced Antioxidant Activity in Patients With Chronic Migraine and Medication-Overuse Headache","translated_title":"","metadata":{"abstract":"Migraine is a complex multifactorial, neurobiological disorder, whose pathogenesis is not fully understood, nor are the mechanisms associated with migraine transformation from episodic to chronic pattern. 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The aim of this cross-sectional study was to determine plasmatic levels of advanced oxidation protein products, ferric-reducing antioxidant power and total plasmatic thiol groups, all plasmatic markers related to oxidative stress, in a sample of chronic migraine patients and medication-overuse headache, compared to a control group of healthy subjects. Thirty-three patients with a diagnosis of both chronic migraine and medication-overuse headache (International Classification of Headache Disorders,3rd edition, be...","internal_url":"https://www.academia.edu/13802029/Evidences_of_Reduced_Antioxidant_Activity_in_Patients_With_Chronic_Migraine_and_Medication_Overuse_Headache","translated_internal_url":"","created_at":"2015-07-08T08:42:27.919-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32903902,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":2637536,"work_id":13802029,"tagging_user_id":32903902,"tagged_user_id":32737123,"co_author_invite_id":null,"email":"f***i@unipi.it","display_order":0,"name":"Filippo Baldacci","title":"Evidences of Reduced Antioxidant Activity in Patients With Chronic Migraine and Medication-Overuse Headache"},{"id":2637543,"work_id":13802029,"tagging_user_id":32903902,"tagged_user_id":32969979,"co_author_invite_id":377941,"email":"g***o@med.unipi.it","display_order":4194304,"name":"Gerstner O","title":"Evidences of Reduced Antioxidant Activity in Patients With Chronic Migraine and Medication-Overuse Headache"},{"id":2637547,"work_id":13802029,"tagging_user_id":32903902,"tagged_user_id":26135594,"co_author_invite_id":null,"email":"u***i@med.unipi.it","affiliation":"University of Pisa","display_order":6291456,"name":"Ubaldo Bonuccelli","title":"Evidences of Reduced Antioxidant Activity in Patients With Chronic Migraine and Medication-Overuse Headache"},{"id":20414882,"work_id":13802029,"tagging_user_id":32737123,"tagged_user_id":31933113,"co_author_invite_id":null,"email":"g***a@neuro.med.unipi.it","affiliation":"University of Pisa","display_order":7340032,"name":"G. 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A &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;am...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Migraine, anxiety and depression often coexist. A &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;neurolimbic&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; model of migraine has been recently proposed accounting for a dynamic influence of pain, mood and anxiety on the migraine disease. However, very few data exist concerning clinical migraine features in patients reporting anxiety-depression symptoms. Aim of our study was to test differences in clinical migraine features between migraineurs with anxiety-depression symptoms and migraineurs without ones. We recruited 200 consecutive migraineurs. Other primary headaches comorbidity and migraine prophylaxis were exclusion criteria. Each patient was interviewed following a structured questionnaire including general features about migraine, triggers, allodynia. Anxiety and depression symptoms were evaluated in each patient by two brief self-reported scales: the generalized anxiety disorder 7-item scale (GAD-7) and the Patient Health Questionnaire 9-item scale (PHQ-9). A cut-off of 5 in both the GAD-7 and the PHQ-9 was considered positive for the presence of anxiety-depressive symptoms. One hundred and one patients (51.5%) had anxiety-depression symptoms (GAD-7 and PHQ-9≥5). They reported a more headaches/month (p=0.004), higher number of triggers (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001), and were more allodynic (p=0.005). In a binary logistic regression model triggers and allodynia made a unique statistical contribution on reporting anxiety-depression symptoms. Our results showed that the presence of anxiety-depression symptoms affects migraine clinical presentation. They are associated with enhanced migraine triggers susceptibility, more ictal allodynic symptoms as well as more headaches/month. An altered sensation in migraineurs with anxiety-depression symptoms could be a result of a lower pain threshold and an increased cortical excitability in a broader context of a neurolimbic dysfunction.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13802028"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13802028"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13802028; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13802028]").text(description); $(".js-view-count[data-work-id=13802028]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13802028; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13802028']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13802028, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=13802028]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13802028,"title":"Migraine features in migraineurs with and without anxiety-depression symptoms: a hospital-based study","translated_title":"","metadata":{"abstract":"Migraine, anxiety and depression often coexist. A \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;neurolimbic\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; model of migraine has been recently proposed accounting for a dynamic influence of pain, mood and anxiety on the migraine disease. However, very few data exist concerning clinical migraine features in patients reporting anxiety-depression symptoms. Aim of our study was to test differences in clinical migraine features between migraineurs with anxiety-depression symptoms and migraineurs without ones. We recruited 200 consecutive migraineurs. Other primary headaches comorbidity and migraine prophylaxis were exclusion criteria. Each patient was interviewed following a structured questionnaire including general features about migraine, triggers, allodynia. Anxiety and depression symptoms were evaluated in each patient by two brief self-reported scales: the generalized anxiety disorder 7-item scale (GAD-7) and the Patient Health Questionnaire 9-item scale (PHQ-9). A cut-off of 5 in both the GAD-7 and the PHQ-9 was considered positive for the presence of anxiety-depressive symptoms. One hundred and one patients (51.5%) had anxiety-depression symptoms (GAD-7 and PHQ-9≥5). They reported a more headaches/month (p=0.004), higher number of triggers (p\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001), and were more allodynic (p=0.005). In a binary logistic regression model triggers and allodynia made a unique statistical contribution on reporting anxiety-depression symptoms. Our results showed that the presence of anxiety-depression symptoms affects migraine clinical presentation. They are associated with enhanced migraine triggers susceptibility, more ictal allodynic symptoms as well as more headaches/month. An altered sensation in migraineurs with anxiety-depression symptoms could be a result of a lower pain threshold and an increased cortical excitability in a broader context of a neurolimbic dysfunction.","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Clinical Neurology and Neurosurgery"},"translated_abstract":"Migraine, anxiety and depression often coexist. A \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;neurolimbic\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; model of migraine has been recently proposed accounting for a dynamic influence of pain, mood and anxiety on the migraine disease. However, very few data exist concerning clinical migraine features in patients reporting anxiety-depression symptoms. Aim of our study was to test differences in clinical migraine features between migraineurs with anxiety-depression symptoms and migraineurs without ones. We recruited 200 consecutive migraineurs. Other primary headaches comorbidity and migraine prophylaxis were exclusion criteria. Each patient was interviewed following a structured questionnaire including general features about migraine, triggers, allodynia. Anxiety and depression symptoms were evaluated in each patient by two brief self-reported scales: the generalized anxiety disorder 7-item scale (GAD-7) and the Patient Health Questionnaire 9-item scale (PHQ-9). A cut-off of 5 in both the GAD-7 and the PHQ-9 was considered positive for the presence of anxiety-depressive symptoms. One hundred and one patients (51.5%) had anxiety-depression symptoms (GAD-7 and PHQ-9≥5). They reported a more headaches/month (p=0.004), higher number of triggers (p\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001), and were more allodynic (p=0.005). In a binary logistic regression model triggers and allodynia made a unique statistical contribution on reporting anxiety-depression symptoms. Our results showed that the presence of anxiety-depression symptoms affects migraine clinical presentation. They are associated with enhanced migraine triggers susceptibility, more ictal allodynic symptoms as well as more headaches/month. An altered sensation in migraineurs with anxiety-depression symptoms could be a result of a lower pain threshold and an increased cortical excitability in a broader context of a neurolimbic dysfunction.","internal_url":"https://www.academia.edu/13802028/Migraine_features_in_migraineurs_with_and_without_anxiety_depression_symptoms_a_hospital_based_study","translated_internal_url":"","created_at":"2015-07-08T08:42:27.795-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32903902,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":2637534,"work_id":13802028,"tagging_user_id":32903902,"tagged_user_id":32737123,"co_author_invite_id":null,"email":"f***i@unipi.it","display_order":0,"name":"Filippo Baldacci","title":"Migraine features in migraineurs with and without anxiety-depression symptoms: a hospital-based study"},{"id":2637539,"work_id":13802028,"tagging_user_id":32903902,"tagged_user_id":32895619,"co_author_invite_id":null,"email":"m***2@ausl.re.it","display_order":4194304,"name":"Michele Poletti","title":"Migraine features in migraineurs with and without anxiety-depression symptoms: a hospital-based study"},{"id":2637553,"work_id":13802028,"tagging_user_id":32903902,"tagged_user_id":32673062,"co_author_invite_id":null,"email":"m***o@gmail.com","display_order":6291456,"name":"M. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13802027"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13802027/Clinical_features_associated_with_ictal_osmophobia_in_migraine"><img alt="Research paper thumbnail of Clinical features associated with ictal osmophobia in migraine" class="work-thumbnail" src="https://attachments.academia-assets.com/44934596/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13802027/Clinical_features_associated_with_ictal_osmophobia_in_migraine">Clinical features associated with ictal osmophobia in migraine</a></div><div class="wp-workCard_item"><span>Neurological Sciences</span><span>, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8e0139e35eb715b4e44967e865876a7f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44934596,"asset_id":13802027,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44934596/download_file?st=MTczMjk5NjI2NSw4LjIyMi4yMDguMTQ2&st=MTczMjk5NjI2NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13802027"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13802027"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13802027; 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Aim of this study was to investigate if migraineurs with ictal osmophobia have particular clinical features comparing to patients without ictal osmophobia. We recruited 200 consecutive migraineurs. Other primary headaches comorbidity and migraine prophylaxis were exclusion criteria. Each patient was interviewed following a structured questionnaire including general features about migraine, depression and anxiety symptoms. Migraine triggers both spontaneously and selecting from a specific list. Allodynia during the migraine attack was measured using the Allodynia symptoms check-list 12 (ASC-12). Eighty four (42 %) patients are non-osmophobic vs. 116 patients (58 %) who are osmophobic. After a logistic regression analysis, pain intensity (OR 1.391; p = 0.008) and anxiety (OR 1.099; p = 0.047) were significantly higher while aura (OR 0.421; p = 0.028) is less frequent in osmophobic migraineurs. We found significant differences in clinical features of osmophobic patients in respect to non-osmophobic ones. 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The objective of this study was to verify the occurrence of sleep-related migraine in a large sample of migraineurs divided in different age groups and to evaluate the possible role of physiological variables (i.e., aging, gender) and comorbidities (i.e., psychiatric diseases). 734 patients (519 women and 215 males), aged 21-70 years, fulfilling IHS criteria (2004) for migraine without aura, were enrolled. The population was divided into five groups according to decades of life and it was evaluated the percentage of sleep-related migraine (at least 75% migraine attacks occurring during night sleep and/or upon awakening) in the different age groups. Headache clinical diary, Pittsburgh Sleep Quality Index and Beck Depression Inventory were also used. The preferential emergence of attacks during night sleep and/or upon awakening progressively increased with aging, without gender predilection; the percentage of patients with sleep-related migraine was: 16% between 20 and 30 years, 27% between 31 and 40 years, 38% between 41 and 50 years, 45% between 51 and 60 years, and 58% between 61 and 70 years, respectively. Poor sleep quality and depression did not account for night-time and/or awakening migraine collocation. 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