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<input id="header-search--input" name="q" type="text" class="form-control form-control-sm" placeholder="Search UCSF clinical trials" title="Search clinical trials at UCSF"> <input class="sr-only form-control-sm btn btn-sm btn-secondary" type="submit" value="Search trials"> </form></div></div> </nav></header><main id="content" class="mx-1 mx-md-0"> <div class="container-xl px-5"><div class="row"><div class="col-md-9 col-lg-8" role="main" id="main-column"><div id="summary" class="page-header show-jargon-definitions"><h1 id="summary--title"> Dynamic Neural Systems Underlying Social-emotional Functions in Older Adults </h1><p class="h3 hide-long-content">a study on <span class="comma-list"><span class="comma-list-item"> <a href="../loneliness">Loneliness</a></span><span class="comma-list-item"> <a href="../neuroimaging">Neuroimaging</a></span><span class="comma-list-item"> <a href="../meditation">Meditation</a></span></span></p></div><div id="trial-details-container"><div id="key-points" class="trial-details-block"><div class="row"> <div class="col"><h2 class="sr-only h3">Summary</h2><dl id="key-points-bullets" class="row"><dt class="d-none d-sm-block col-sm-1 col-lg-2"> <i class="fa fa-user fa-lg fa-fw" aria-hidden="true"></i> <span class="sr-only">Eligibility</span></dt><dd class="col-12 col-sm-11 col-lg-10"> <strong>for people ages 60-120</strong> (<a href="#eligibility">full criteria</a>) </dd><dt class="d-none d-sm-block col-sm-1 col-lg-2"> <i class="fa fa-check-circle fa-lg fa-fw" aria-hidden="true"></i> <span class="sr-only">Healthy Volunteers</span></dt><dd class="col-12 col-sm-11 col-lg-10"> <strong>healthy people welcome</strong> </dd><dt class="d-none d-sm-block col-sm-1 col-lg-2"> <i class="fa fa-map-marker fa-lg fa-fw" aria-hidden="true"></i> <span class="sr-only">Location</span></dt><dd class="col-12 col-sm-11 col-lg-10"> <a href="#location"> at San Francisco, California </a> </dd><dt class="d-none d-sm-block col-sm-1 col-lg-2"> <i class="fa fa-calendar fa-lg fa-fw" aria-hidden="true"></i> <span class="sr-only">Dates</span></dt><dd class="col-12 col-sm-11 col-lg-10"><div> study started <span itemscope itemtype="https://schema.org/WebPage"><time itemprop="dateCreated" datetime="2023-10-13">October 2023</time></span></div><div> completion around <time datetime="2025-12-28">December 2025</time></div><div itemscope itemtype="https://schema.org/WebPage" aria-hidden="true" class="d-none"><meta itemprop="datePublished" content="2022-12-12"></div></dd><dt class="d-none d-sm-block col-sm-1 col-lg-2"> <i class="fa fa-user-md fa-lg fa-fw" aria-hidden="true"></i> <span class="sr-only">Principal Investigator</span></dt><dd class="col-12 col-sm-11 col-lg-10 comma-list"> by <span class="pi-name comma-list-item"><span><a href="https://www.google.com/search?q=Lorenzo%20Pasquini%20ucsf&btnI" target="_blank" rel="noopener nofollow" class="trial--link-to-pi-profile">Lorenzo Pasquini, PhD</a></span></span></dd></dl></div> <div class="d-none d-md-block col-md-auto" id="pi-photos-block"></div></div></div><div id="description" class="trial-details-block"><h2 class="h3">Description</h2><div class="show-jargon-definitions"><h3 class="h4">Summary</h3><div class="hide-long-content"><p>Assess the impact of a remote, app-delivered digital <a href="../meditation" class="trial--link-to-condition-in-text">meditation</a> intervention on emotional well-being of lonely older adults. <a href="../neuroimaging" class="trial--link-to-condition-in-text">Neuroimaging</a> and autonomic physiology will be used to assess the neural correlates of the intervention.</p></div><h3 class="h4">Keywords</h3><p class=" hide-long-content"><span> <a href="../loneliness" class="trial--link-to-condition-in-text">Loneliness</a></span>, <span> Older Adults</span>, <span> fMRI</span>, <span> Emotions</span>, <span> EEG</span>, <span> Digital Intervention</span>, <span> <a href="../meditation" class="trial--link-to-condition-in-text">Meditation</a></span>, <span> intervention</span></p></div></div><div id="eligibility" class="trial-details-block show-jargon-definitions"><h2 class="h3">Eligibility</h2><div class="hide-long-content"><div class="row"><div class="col-12 col-lg-6"><h3 class="h4 mt-0"> <i class="fa fa-check-square-o" aria-hidden="true"></i> You can join if… </h3><div><p><strong>Open to people ages 60-120</strong></p><ul><li>60 years of age or older</li><li>English language fluency</li><li>Naive to <a href="../meditation" class="trial--link-to-condition-in-text">meditation</a> practices (not actively meditating more than one hour per month and/or meditation practice for less than a year in their entire life-time)</li><li>No MRI contra-indications</li><li>Cognitively healthy (no diagnosis of <a href="../dementia" class="trial--link-to-condition-in-text">dementia</a>, stroke, developmental disorders, or major systemic diseases that may impact cognitive function)</li></ul></div></div><div class="col-12 col-lg-6"><h3 class="h4 mt-0"> <i class="fa fa-ban" aria-hidden="true"></i> You CAN'T join if... </h3><div><ul><li>Below 60 years of age</li><li>Not fluent in English</li><li>Active meditator (meditating more than one hour per month and/or meditation practice for more than a year in their entire life-time).</li><li>Presence of a severe psychiatric (e.g. <a href="../schizophrenia" class="trial--link-to-condition-in-text">schizophrenia</a>, <a href="../bipolar-disorder" class="trial--link-to-condition-in-text">bipolar disorder</a>, PTSD), neurological (epilepsy, <a href="../traumatic-brain-injury" class="trial--link-to-condition-in-text">traumatic brain injury</a>, dementia, multiple sclerosis), or developmental disorder (e.g. autism)</li><li>Systemic disease (e.g. major recent surgeries, cancer)</li><li>Claustrophobia</li><li>Contraindications for MR safety (e.g. metal in body, cochlea implants)</li></ul></div></div></div></div></div><div id="location" class="trial-details-block"><h2 class="h3">Location</h2><ul id="locations-list" class="hide-long-content locations-list--only-one-location"><li class="location location-is-institutional" itemprop="address" itemscope itemtype="https://schema.org/PostalAddress"><span class="location-name" itemprop="name">UCSF</span><wbr> <span class="badge badge-secondary">accepting new patients</span><br><span class="location-address comma-list comma-list--without-and"><span class="comma-list-item" itemprop="addressLocality"> San Francisco</span><span class="comma-list-item" itemprop="addressRegion"> California</span><span class="comma-list-item" itemprop="postalCode"> 94158</span><span class="comma-list-item" itemprop="addressCountry"> United States</span></span></li></ul></div><div id="pis" class="trial-details-block"><h2 class="h3">Lead Scientist <span class="d-none d-sm-inline">at UCSF</span></h2><ul class="pis-list--only-one-pi"><li class="pi"><span class="pi-name"> <strong> <a href="https://www.google.com/search?q=Lorenzo%20Pasquini%20ucsf&btnI" target="_blank" rel="noopener nofollow" class="trial--link-to-pi-profile">Lorenzo Pasquini, PhD</a> </strong> </span></li></ul></div><div id="details" class="trial-details-block"><h2 class="h3">Details</h2><dl class="row"><dt class="col-sm-3 text-sm-right">Status</dt><dd class="col-sm-9"> accepting new patients </dd><dt class="col-sm-3 text-sm-right">Start Date</dt><dd class="col-sm-9"><time datetime="2023-10-13">October 2023</time></dd><dt class="col-sm-3 text-sm-right">Completion Date</dt><dd class="col-sm-9"><time datetime="2025-12-28">December 2025</time> (estimated)</dd><dt class="col-sm-3 text-sm-right">Sponsor</dt><dd class="col-sm-9">University of California, San Francisco</dd><dt class="col-sm-3 text-sm-right">ID</dt><dd class="col-sm-9"> <a href="https://clinicaltrials.gov/ct2/show/NCT05645835" class="trial--link-to-clinicaltrials-gov" target="_blank" rel="noopener nofollow" title="ClinicalTrials.gov identifier">NCT05645835</a> </dd><dt class="col-sm-3 text-sm-right">Study Type</dt><dd class="col-sm-9">Interventional</dd><dt class="col-sm-3 text-sm-right">Participants</dt><dd class="col-sm-9">Expecting 40 study participants</dd><dt class="col-sm-3 text-sm-right">Last Updated</dt><dd class="col-sm-9"><span itemscope itemtype="https://schema.org/WebPage"><time itemprop="dateModified" datetime="2023-11-27">November 2023</time></span></dd></dl></div><div id="faq" class="trial-details-block d-print-none" role="complementary"><h2 class="h3">Frequently Asked Questions</h2><ul><li><a href="../about/how-clinical-trials-work">How Do Clinical Trials Work?</a></li><li><a href="../about/what-to-expect">What to Expect</a></li><li><a href="../about/who-can-join">Who Can Join</a></li><li><a href="../about/our-researchers">Our Researchers</a></li></ul></div><div class="text-center my-3"> <a href="#" id="contact-button-end" class="btn btn-primary btn-lg d-none d-md-inline" data-toggle="modal" data-target="#contact-modal" aria-description="Are you interested? 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