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class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Cell type</div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Juvenile_xanthogranuloma_-_very_high_mag.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/4/43/Juvenile_xanthogranuloma_-_very_high_mag.jpg/220px-Juvenile_xanthogranuloma_-_very_high_mag.jpg" decoding="async" width="220" height="147" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/43/Juvenile_xanthogranuloma_-_very_high_mag.jpg/330px-Juvenile_xanthogranuloma_-_very_high_mag.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/43/Juvenile_xanthogranuloma_-_very_high_mag.jpg/440px-Juvenile_xanthogranuloma_-_very_high_mag.jpg 2x" data-file-width="4272" data-file-height="2848" /></a><figcaption>Touton giant cells in a <a href="/wiki/Juvenile_xanthogranuloma" title="Juvenile xanthogranuloma">juvenile xanthogranuloma</a>. <a href="/wiki/H%26E_stain" title="H&E stain">H&E stain</a>.</figcaption></figure> <p><b>Touton giant cells</b> are a type of <a href="/wiki/Multinucleated_giant_cell" class="mw-redirect" title="Multinucleated giant cell">multinucleated giant cell</a> seen in lesions with high <a href="/wiki/Lipid" title="Lipid">lipid</a> content such as <a href="/wiki/Fat_necrosis" title="Fat necrosis">fat necrosis</a>, <a href="/wiki/Xanthoma" title="Xanthoma">xanthoma</a>, and xanthelasma and <a href="/wiki/Xanthogranuloma" class="mw-redirect" title="Xanthogranuloma">xanthogranulomas</a>. They are also found in <a href="/wiki/Dermatofibroma" title="Dermatofibroma">dermatofibroma</a>.<sup id="cite_ref-Bolognia_1-0" class="reference"><a href="#cite_note-Bolognia-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="History">History</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Touton_giant_cell&action=edit&section=1" title="Edit section: History"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Touton giant cells are named for <a href="/wiki/Karl_Touton" title="Karl Touton">Karl Touton</a>, a German <a href="/wiki/Botanist" class="mw-redirect" title="Botanist">botanist</a> and <a href="/wiki/Dermatologist" class="mw-redirect" title="Dermatologist">dermatologist</a>.<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> Karl Touton first observed these cells in 1885 and named them "xanthelasmatic giant cells", a name which has since fallen out of favor.<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Appearance">Appearance</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Touton_giant_cell&action=edit&section=2" title="Edit section: Appearance"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Touton giant cells, being multinucleated giant cells, can be distinguished by the presence of several nuclei in a distinct pattern. They contain a ring of <a href="/wiki/Cell_nucleus" title="Cell nucleus">nuclei</a> surrounding a central homogeneous <a href="/wiki/Cytoplasm" title="Cytoplasm">cytoplasm</a>, while foamy cytoplasm surrounds the nuclei.<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> The cytoplasm surrounded by the nuclei has been described as both <a href="/wiki/Amphophilic" class="mw-redirect" title="Amphophilic">amphophilic</a> and <a href="/wiki/Eosinophilic" title="Eosinophilic">eosinophilic</a>, while the cytoplasm near the periphery of the cell is pale and foamy in appearance.<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Causes">Causes</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Touton_giant_cell&action=edit&section=3" title="Edit section: Causes"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Touton giant cells are formed by the fusion of macrophage-derived foam cells. It has been suggested that <a href="/wiki/Cytokines" class="mw-redirect" title="Cytokines">cytokines</a> such as <a href="/wiki/Interferon_gamma" title="Interferon gamma">interferon gamma</a>, <a href="/wiki/Interleukin-3" class="mw-redirect" title="Interleukin-3">interleukin-3</a>, and <a href="/wiki/M-CSF" class="mw-redirect" title="M-CSF">M-CSF</a> may be involved in the production of Touton giant cells.<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Touton_giant_cell&action=edit&section=4" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-Bolognia-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-Bolognia_1-0">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFRapini,_Ronald_P.Bolognia,_Jean_L.Jorizzo,_Joseph_L.2007" class="citation book cs1">Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). <i>Dermatology: 2-Volume Set</i>. St. Louis: Mosby. pp. 14, 15. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-1-4160-2999-1" title="Special:BookSources/978-1-4160-2999-1"><bdi>978-1-4160-2999-1</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Dermatology%3A+2-Volume+Set&rft.place=St.+Louis&rft.pages=14%2C+15&rft.pub=Mosby&rft.date=2007&rft.isbn=978-1-4160-2999-1&rft.au=Rapini%2C+Ronald+P.&rft.au=Bolognia%2C+Jean+L.&rft.au=Jorizzo%2C+Joseph+L.&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATouton+giant+cell" class="Z3988"></span></span> </li> <li id="cite_note-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-2">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFAtermanRemmeleSmith1988" class="citation journal cs1">Aterman, K.; Remmele, W.; Smith, M. (Jun 1988). "Karl Touton and his "xanthelasmatic giant cell." A selective review of multinucleated giant cells". <i>The American Journal of Dermatopathology</i>. <b>10</b> (3): 257–269. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1097%2F00000372-198806000-00012">10.1097/00000372-198806000-00012</a>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/0193-1091">0193-1091</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/3068999">3068999</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+American+Journal+of+Dermatopathology&rft.atitle=Karl+Touton+and+his+%22xanthelasmatic+giant+cell.%22+A+selective+review+of+multinucleated+giant+cells&rft.volume=10&rft.issue=3&rft.pages=257-269&rft.date=1988-06&rft.issn=0193-1091&rft_id=info%3Apmid%2F3068999&rft_id=info%3Adoi%2F10.1097%2F00000372-198806000-00012&rft.aulast=Aterman&rft.aufirst=K.&rft.au=Remmele%2C+W.&rft.au=Smith%2C+M.&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATouton+giant+cell" class="Z3988"></span></span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFOlson1989" class="citation book cs1">Olson, James (1989). <i>The History of Cancer: An Annotated Bibliography</i>. ABC-CLIO. p. 139. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/9780313258893" title="Special:BookSources/9780313258893"><bdi>9780313258893</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=The+History+of+Cancer%3A+An+Annotated+Bibliography&rft.pages=139&rft.pub=ABC-CLIO&rft.date=1989&rft.isbn=9780313258893&rft.aulast=Olson&rft.aufirst=James&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATouton+giant+cell" class="Z3988"></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGrant-Kels2007" class="citation book cs1">Grant-Kels, Jane (2007). <i>Color Atlas of Dermatopathology</i>. City: Informa Healthcare. pp. 107, 119. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-0-8493-3794-9" title="Special:BookSources/978-0-8493-3794-9"><bdi>978-0-8493-3794-9</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Color+Atlas+of+Dermatopathology&rft.place=City&rft.pages=107%2C+119&rft.pub=Informa+Healthcare&rft.date=2007&rft.isbn=978-0-8493-3794-9&rft.aulast=Grant-Kels&rft.aufirst=Jane&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATouton+giant+cell" class="Z3988"></span></span> </li> <li id="cite_note-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-5">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCarmen_Gómez-MateoMonteagudo2013" class="citation journal cs1">Carmen Gómez-Mateo, Maria; Monteagudo, Carlos (2013). <a rel="nofollow" class="external text" href="http://www.semdiagpath.com/article/S0740-2570(12)00009-3/fulltext">"Nonepithelial skin tumors with multinucleated giant cells"</a>. <i>Seminars in Diagnostic Pathology</i>. <b>30</b> (1): 58–72. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1053%2Fj.semdp.2012.01.004">10.1053/j.semdp.2012.01.004</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/23327730">23327730</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Seminars+in+Diagnostic+Pathology&rft.atitle=Nonepithelial+skin+tumors+with+multinucleated+giant+cells&rft.volume=30&rft.issue=1&rft.pages=58-72&rft.date=2013&rft_id=info%3Adoi%2F10.1053%2Fj.semdp.2012.01.004&rft_id=info%3Apmid%2F23327730&rft.aulast=Carmen+G%C3%B3mez-Mateo&rft.aufirst=Maria&rft.au=Monteagudo%2C+Carlos&rft_id=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FS0740-2570%2812%2900009-3%2Ffulltext&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATouton+giant+cell" class="Z3988"></span></span> </li> <li id="cite_note-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-6">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSequeiraGandhi2012" class="citation journal cs1">Sequeira, Fiona; Gandhi, Suneil (2012). <a rel="nofollow" class="external text" href="http://www.ijdvl.com/article.asp?issn=0378-6323;year=2012;volume=78;issue=2;spage=207;epage=216;aulast=Sequeira">"Named cells in dermatology"</a>. <i>Indian Journal of Dermatology, Venereology and Leprology</i>. <b>78</b> (2): 207–16. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.4103%2F0378-6323.93650">10.4103/0378-6323.93650</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22421663">22421663</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Indian+Journal+of+Dermatology%2C+Venereology+and+Leprology&rft.atitle=Named+cells+in+dermatology&rft.volume=78&rft.issue=2&rft.pages=207-16&rft.date=2012&rft_id=info%3Adoi%2F10.4103%2F0378-6323.93650&rft_id=info%3Apmid%2F22421663&rft.aulast=Sequeira&rft.aufirst=Fiona&rft.au=Gandhi%2C+Suneil&rft_id=http%3A%2F%2Fwww.ijdvl.com%2Farticle.asp%3Fissn%3D0378-6323%3Byear%3D2012%3Bvolume%3D78%3Bissue%3D2%3Bspage%3D207%3Bepage%3D216%3Baulast%3DSequeira&rfr_id=info%3Asid%2Fen.wikipedia.org%3ATouton+giant+cell" class="Z3988"></span></span> </li> <li id="cite_note-7"><span class="mw-cite-backlink"><b><a href="#cite_ref-7">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFQuinnSchepetkin2009" class="citation journal cs1">Quinn, Mark; 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class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Touton_giant_cell&action=edit&section=5" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="http://www.copewithcytokines.de/cope.cgi?key=Touton%20giant%20cells">Cytokines & Cells Online Pathfinder Encyclopaedia</a></li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output 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.navbox-image img{max-width:none!important}@media print{body.ns-0 .mw-parser-output .navbox{display:none!important}}</style></div><div role="navigation" class="navbox" aria-labelledby="Myeloid_blood_cells_and_plasma" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><style data-mw-deduplicate="TemplateStyles:r1239400231">.mw-parser-output .navbar{display:inline;font-size:88%;font-weight:normal}.mw-parser-output .navbar-collapse{float:left;text-align:left}.mw-parser-output .navbar-boxtext{word-spacing:0}.mw-parser-output .navbar ul{display:inline-block;white-space:nowrap;line-height:inherit}.mw-parser-output .navbar-brackets::before{margin-right:-0.125em;content:"[ "}.mw-parser-output .navbar-brackets::after{margin-left:-0.125em;content:" ]"}.mw-parser-output .navbar li{word-spacing:-0.125em}.mw-parser-output .navbar a>span,.mw-parser-output .navbar a>abbr{text-decoration:inherit}.mw-parser-output .navbar-mini abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:114%;margin:0 7em}.mw-parser-output .navbar-ct-mini{font-size:114%;margin:0 4em}html.skin-theme-clientpref-night .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}@media(prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Myeloid_blood_cells_and_plasma" title="Template:Myeloid blood cells and plasma"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Myeloid_blood_cells_and_plasma" title="Template talk:Myeloid blood cells and plasma"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Myeloid_blood_cells_and_plasma" title="Special:EditPage/Template:Myeloid blood cells and plasma"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Myeloid_blood_cells_and_plasma" style="font-size:114%;margin:0 4em">Myeloid blood cells and <a href="/wiki/Blood_plasma" title="Blood plasma">plasma</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Haematopoiesis" title="Haematopoiesis">Hematopoiesis</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="Myelopoiesis(CFU-GEMM)" scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Myelopoiesis" title="Myelopoiesis">Myelopoiesis</a><br />(<a href="/wiki/CFU-GEMM" title="CFU-GEMM">CFU-GEMM</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/CFU-GM" title="CFU-GM">CFU-GM</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Granulopoiesis" title="Granulopoiesis">Granulopoiesis</a> <ul><li><a href="/wiki/Myeloblast" title="Myeloblast">Myeloblast</a></li> <li><a href="/wiki/Promyelocyte" title="Promyelocyte">Promyelocyte</a></li> <li><a href="/wiki/Myelocyte" title="Myelocyte">Myelocyte</a></li> <li><a href="/wiki/Metamyelocyte" title="Metamyelocyte">Metamyelocyte</a></li> <li><a href="/wiki/Band_cell" title="Band cell">Band cell</a></li></ul></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Monocytopoiesis" title="Monocytopoiesis">Monocytopoiesis</a> <ul><li><a href="/wiki/Monoblast" title="Monoblast">Monoblast</a></li> <li><a href="/wiki/Promonocyte" title="Promonocyte">Promonocyte</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Megakaryocyte%E2%80%93erythroid_progenitor_cell" title="Megakaryocyte–erythroid progenitor cell">MEP</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Thrombopoiesis" title="Thrombopoiesis">Thrombopoiesis</a> <ul><li><a href="/wiki/Megakaryoblast" title="Megakaryoblast">Megakaryoblast</a></li> <li><a href="/wiki/Promegakaryocyte" title="Promegakaryocyte">Promegakaryocyte</a></li></ul></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Erythropoiesis" title="Erythropoiesis">Erythropoiesis</a> <ul><li><a href="/wiki/Proerythroblast" title="Proerythroblast">Proerythroblast</a></li> <li><a href="/wiki/Normoblast" class="mw-redirect" title="Normoblast">Normoblast</a></li> <li><a href="/wiki/Reticulocyte" title="Reticulocyte">Reticulocyte</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">General</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Extramedullary_hematopoiesis" title="Extramedullary hematopoiesis">Extramedullary hematopoiesis</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Myeloid_tissue" title="Myeloid tissue">Myeloid tissue</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Granulocyte" title="Granulocyte">Granulocytes</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Myeloblast" title="Myeloblast">Myeloblast</a></li> <li><a href="/wiki/Band_cell" title="Band cell">Band cell</a></li> <li><a href="/wiki/Neutrophil" title="Neutrophil">Neutrophil</a></li> <li><a href="/wiki/Basophil" title="Basophil">Basophil</a> <ul><li><a href="/wiki/CFU-Baso" title="CFU-Baso">CFU-Baso</a></li></ul></li> <li><a href="/wiki/Eosinophil" title="Eosinophil">Eosinophil</a> <ul><li><a href="/wiki/CFU-Eos" title="CFU-Eos">CFU-Eos</a></li></ul></li> <li><a href="/wiki/Mast_cell" title="Mast cell">Mast cell</a> <ul><li><a href="/wiki/CFU-Mast" title="CFU-Mast">CFU-Mast</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Monocyte" title="Monocyte">Monocytes</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Macrophage" title="Macrophage">Macrophages</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Histiocyte" title="Histiocyte">Histiocytes</a></li> <li><a href="/wiki/Kupffer_cell" title="Kupffer cell">Kupffer cells</a></li> <li><a href="/wiki/Alveolar_macrophage" title="Alveolar macrophage">Alveolar macrophage</a></li> <li><a href="/wiki/Microglia" title="Microglia">Microglia</a></li> <li><a href="/wiki/Osteoclast" title="Osteoclast">Osteoclasts</a></li> <li><a href="/wiki/Epithelioid_cell" title="Epithelioid cell">Epithelioid cells</a></li> <li><a href="/wiki/Giant_cell" title="Giant cell">giant cells</a> <ul><li><a href="/wiki/Langhans_giant_cell" title="Langhans giant cell">Langhans giant cells</a></li> <li><a href="/wiki/Foreign-body_giant_cell" title="Foreign-body giant cell">Foreign-body giant cell</a></li> <li><a class="mw-selflink selflink">Touton giant cells</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Antigen-presenting cells <ul><li><a href="/wiki/Dendritic_cell" title="Dendritic cell">Dendritic cells</a></li> <li><a href="/wiki/Langerhans_cell" title="Langerhans cell">Langerhans cell</a></li> <li><a href="/wiki/CFU-DL" title="CFU-DL">CFU-DL</a></li></ul></li> <li><a href="/wiki/Monoblast" title="Monoblast">Monoblast</a> <ul><li><a href="/wiki/Mononuclear_phagocyte_system" title="Mononuclear phagocyte system">MPS</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Platelet" title="Platelet">Platelets</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CFU-Meg" title="CFU-Meg">CFU-Meg</a></li> <li><a href="/wiki/Megakaryoblast" title="Megakaryoblast">Megakaryoblast</a></li> <li><a href="/wiki/Promegakaryocyte" title="Promegakaryocyte">Promegakaryocyte</a></li> <li><a href="/wiki/Megakaryocyte" title="Megakaryocyte">Megakaryocyte</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Red_blood_cell" title="Red blood cell">Red blood cells</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Reticulocyte" title="Reticulocyte">Reticulocyte</a></li> <li><a href="/wiki/Nucleated_red_blood_cell" title="Nucleated red blood cell">Nucleated red blood cell</a></li> <li><a href="/wiki/CFU-E" title="CFU-E">CFU-E</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Immune response</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Leukocyte_extravasation" title="Leukocyte extravasation">Leukocyte extravasation</a></li> <li><a href="/wiki/Phagocytosis" title="Phagocytosis">Phagocytosis</a></li> <li><a href="/wiki/Intrinsic_immunity" title="Intrinsic immunity">Intrinsic immunity</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Precursor cells <ul><li><a href="/wiki/CFU-GM" title="CFU-GM">CFU-GM</a></li> <li><a href="/wiki/Megakaryocyte%E2%80%93erythroid_progenitor_cell" title="Megakaryocyte–erythroid progenitor cell">Megakaryocyte–erythroid progenitor cell</a></li> <li><a href="/wiki/CFU-GEMM" title="CFU-GEMM">CFU-GEMM</a></li></ul></li> <li><a href="/wiki/Myelomonocyte" title="Myelomonocyte">Myelomonocyte</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" 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