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Idir</title> <meta name="description" content="Search results for: Belaidi Idir"> <meta name="keywords" content="Belaidi Idir"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" type="button" data-toggle="collapse" data-target="#navbarMenu" aria-controls="navbarMenu" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="w-100"> <div class="d-none d-lg-flex flex-row-reverse"> <form method="get" action="https://waset.org/search" class="form-inline my-2 my-lg-0"> <input class="form-control mr-sm-2" type="search" placeholder="Search Conferences" value="Belaidi Idir" name="q" aria-label="Search"> <button class="btn btn-light my-2 my-sm-0" type="submit"><i class="fas fa-search"></i></button> </form> </div> <div class="collapse navbar-collapse mt-1" id="navbarMenu"> <ul class="navbar-nav ml-auto align-items-center" id="mainNavMenu"> <li class="nav-item"> <a class="nav-link" href="https://waset.org/conferences" title="Conferences in 2024/2025/2026">Conferences</a> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/disciplines" title="Disciplines">Disciplines</a> </li> <li 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Belaidi Idir"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 17</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Belaidi Idir</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">17</span> The Consequences of Vibrations in Machining</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Boughedaoui%20Rachid">Boughedaoui Rachid</a>, <a href="https://publications.waset.org/abstracts/search?q=Belaidi%20Idir"> Belaidi Idir</a>, <a href="https://publications.waset.org/abstracts/search?q=Ouali%20Mohamed"> Ouali Mohamed</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The formatting by removal of material remains an indispensable means for obtaining different forms of pieces. The objective of this work is to study the influence of parameters of the vibratory regime of the system PTM 'Piece-Tool-Machine, in the case of the machining of the thin pieces on the surface finish. As a first step, an analytical study of essential dynamic models 2D slice will be presented. The stability lobes will be thus obtained. In a second step, a characterization of PTM system will be realized. This system will be instrumented with accelerometric sensors but also a laser vibrometer so as to have the information closer to the cutting area. Dynamometers three components will be used for the analysis of cutting forces. Surface states will be measured and the condition of the cutting edge will be visualized thanks to a binocular microscope coupled to a data acquisition system. This information will allow quantifying the influence of chatter on the dimensional quality of the parts. From lobes stabilities previously determined experimental validation allow for the development a method for detecting of the phenomenon of chatter and so an approach will be proposed. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=chatter" title="chatter">chatter</a>, <a href="https://publications.waset.org/abstracts/search?q=dynamic" title=" dynamic"> dynamic</a>, <a href="https://publications.waset.org/abstracts/search?q=milling" title=" milling"> milling</a>, <a href="https://publications.waset.org/abstracts/search?q=lobe%20stability" title=" lobe stability"> lobe stability</a> </p> <a href="https://publications.waset.org/abstracts/15532/the-consequences-of-vibrations-in-machining" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/15532.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">357</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">16</span> Applying Element Free Galerkin Method on Beam and Plate</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mahdad%20M%E2%80%99hamed">Mahdad M’hamed</a>, <a href="https://publications.waset.org/abstracts/search?q=Belaidi%20Idir"> Belaidi Idir</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This paper develops a meshless approach, called Element Free Galerkin (EFG) method, which is based on the weak form Moving Least Squares (MLS) of the partial differential governing equations and employs the interpolation to construct the meshless shape functions. The variation weak form is used in the EFG where the trial and test functions are approximated bye the MLS approximation. Since the shape functions constructed by this discretization have the weight function property based on the randomly distributed points, the essential boundary conditions can be implemented easily. The local weak form of the partial differential governing equations is obtained by the weighted residual method within the simple local quadrature domain. The spline function with high continuity is used as the weight function. The presently developed EFG method is a truly meshless method, as it does not require the mesh, either for the construction of the shape functions, or for the integration of the local weak form. Several numerical examples of two-dimensional static structural analysis are presented to illustrate the performance of the present EFG method. They show that the EFG method is highly efficient for the implementation and highly accurate for the computation. The present method is used to analyze the static deflection of beams and plate hole <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=numerical%20computation" title="numerical computation">numerical computation</a>, <a href="https://publications.waset.org/abstracts/search?q=element-free%20Galerkin%20%28EFG%29" title=" element-free Galerkin (EFG)"> element-free Galerkin (EFG)</a>, <a href="https://publications.waset.org/abstracts/search?q=moving%20least%20squares%20%28MLS%29" title=" moving least squares (MLS)"> moving least squares (MLS)</a>, <a href="https://publications.waset.org/abstracts/search?q=meshless%20methods" title=" meshless methods"> meshless methods</a> </p> <a href="https://publications.waset.org/abstracts/50344/applying-element-free-galerkin-method-on-beam-and-plate" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/50344.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">283</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">15</span> Bioinsecticidal Activity and Phytochemical Study of the Crude Extract from the Plant Artemisia judaica</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Fatma%20Acheuk">Fatma Acheuk</a>, <a href="https://publications.waset.org/abstracts/search?q=Idir%20Bitam"> Idir Bitam</a>, <a href="https://publications.waset.org/abstracts/search?q=Leila%20Bendifallah"> Leila Bendifallah</a>, <a href="https://publications.waset.org/abstracts/search?q=Malika%20Ramdani"> Malika Ramdani</a>, <a href="https://publications.waset.org/abstracts/search?q=Fethia%20Barika"> Fethia Barika</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Phytochemical study of the plant Artemisia judaica showed the presence of various groups of natural products: saponins, tannins, coumarins, flavonoids, carbohydrates, and reducer compounds. However, alkaloids are present as traces. The crude ethanol extract of the test plant presented significant insecticidal activity on mosquito larvae in stage I, II and III. The LD50 highlighted the excellent insecticidal effect of the tested extract. Similarly, the LT50 are achieved early with high doses. The results obtained are encouraging and suggest the possibility of using the secondary metabolites of this plant such as bio-insecticide. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Atamisia%20judaica" title="Atamisia judaica">Atamisia judaica</a>, <a href="https://publications.waset.org/abstracts/search?q=crud%20extract" title=" crud extract"> crud extract</a>, <a href="https://publications.waset.org/abstracts/search?q=mosquito" title=" mosquito"> mosquito</a>, <a href="https://publications.waset.org/abstracts/search?q=insecticidal%20activity" title=" insecticidal activity"> insecticidal activity</a> </p> <a href="https://publications.waset.org/abstracts/24116/bioinsecticidal-activity-and-phytochemical-study-of-the-crude-extract-from-the-plant-artemisia-judaica" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/24116.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">519</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14</span> Phytochemical Study and Bioinsecticidal Effect of the Crude Extract from the Plant Artemisia Judaica</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Fatma%20Acheuk">Fatma Acheuk</a>, <a href="https://publications.waset.org/abstracts/search?q=Idir%20Bitam"> Idir Bitam</a>, <a href="https://publications.waset.org/abstracts/search?q=Leila%20Bendifallah"> Leila Bendifallah</a>, <a href="https://publications.waset.org/abstracts/search?q=Malika%20Ramdani"> Malika Ramdani</a>, <a href="https://publications.waset.org/abstracts/search?q=Fethia%20Barika"> Fethia Barika</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Phytochemical study of the plant Artemisia judaica showed the presence of various groups of natural products: saponins, tannins, coumarins, flavonoids, carbohydrates, and reducer compounds. However alkaloids are present as traces. The crude ethanol extract of the test plant presented significant insecticidal activity on mosquito larvae in stage I, II, and III. The LD50 highlighted the excellent insecticidal effect of the tested extract. Similarly, the LT50 are achieved early with high doses. The results obtained are encouraging and suggest the possibility of using the secondary metabolites of this plant such as bio-insecticide. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Atamisia%20judaica" title="Atamisia judaica">Atamisia judaica</a>, <a href="https://publications.waset.org/abstracts/search?q=crud%20extract" title=" crud extract"> crud extract</a>, <a href="https://publications.waset.org/abstracts/search?q=mosquito" title=" mosquito"> mosquito</a>, <a href="https://publications.waset.org/abstracts/search?q=insecticidal%20activity" title=" insecticidal activity"> insecticidal activity</a> </p> <a href="https://publications.waset.org/abstracts/21689/phytochemical-study-and-bioinsecticidal-effect-of-the-crude-extract-from-the-plant-artemisia-judaica" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/21689.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">590</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">13</span> 2,7-Diazaindole as a Photophysical Probe for Excited State Hydrogen/Proton Transfer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Simran%20Baweja">Simran Baweja</a>, <a href="https://publications.waset.org/abstracts/search?q=Bhavika%20Kalal"> Bhavika Kalal</a>, <a href="https://publications.waset.org/abstracts/search?q=Surajit%20Maity"> Surajit Maity</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Photoinduced tautomerization reactions have been the centre of attention among the scientific community over the past several decades because of their significance in various biological systems. 7-azaindole (7AI) is considered a model system for DNA base pairing and to understand the role of such tautomerization reactions in mutations. To the best of our knowledge, extensive studies have been carried out on 7-azaindole and its solvent clusters exhibiting proton/ hydrogen transfer in both solution as well as gas phases. Derivatives of the above molecule, like 2,7- and 2,6-diazaindoles are proposed to have even better photophysical properties due to the presence of -aza group on the 2nd position. However, there are studies in the solution phase that suggest the relevance of these molecules, but there are no experimental studies reported in the gas phase yet. In our current investigation, we present the first gas phase spectroscopic data of 2,7-diazaindole (2,7-DAI) and its solvent cluster (2,7-DAI-H2O). In this, we have employed state-of-the-art laser spectroscopic methods such as fluorescence excitation (LIF), dispersed fluorescence (DF), resonant two-photon ionization-time of flight mass spectrometry (2C-R2PI), photoionization efficiency spectroscopy (PIE), IR-UV double resonance spectroscopy, i.e., fluorescence-dip infrared spectroscopy (FDIR) and resonant ion-dip infrared spectroscopy (IDIR) to understand the electronic structure of the molecule. The origin band corresponding to the S1 ← S0 transition of the bare 2,7-DAI is found to be positioned at 33910 cm-1, whereas the origin band corresponding to S1 ← S0 transition of the 2,7-DAI-H2O is positioned at 33074 cm-1. The red-shifted transition in the case of solvent cluster suggests the enhanced feasibility of excited state hydrogen/ proton transfer. The ionization potential for the 2,7-DAI molecule is found to be 8.92 eV which is significantly higher than the previously reported 7AI (8.11 eV) molecule, making it a comparatively complex molecule to study. The ionization potential is reduced by 0.14 eV in the case of 2,7-DAI-H2O (8.78 eV) cluster compared to that of 2,7-DAI. Moreover, on comparison with the available literature values of 7AI, we found the origin band of 2,7-DAI and 2,7-DAI-H2O to be red-shifted by -729 and -280 cm-1 respectively. The ground and excited state N-H stretching frequencies of the 27DAI molecule were determined using fluorescence-dip infrared spectra (FDIR) and resonant ion dip infrared spectroscopy (IDIR), obtained at 3523 and 3467 cm-1, respectively. The lower value of vNH in the electronically excited state of 27DAI implies the higher acidity of the group compared to the ground state. Moreover, we have done extensive computational analysis, which suggests that the energy barrier in the excited state reduces significantly as we increase the number of catalytic solvent molecules (S= H2O, NH3) as well as the polarity of solvent molecules. We found that the ammonia molecule is a better candidate for hydrogen transfer compared to water because of its higher gas-phase basicity. Further studies are underway to understand the excited state dynamics and photochemistry of such N-rich chromophores. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=excited%20state%20hydrogen%20transfer" title="excited state hydrogen transfer">excited state hydrogen transfer</a>, <a href="https://publications.waset.org/abstracts/search?q=supersonic%20expansion" title=" supersonic expansion"> supersonic expansion</a>, <a href="https://publications.waset.org/abstracts/search?q=gas%20phase%20spectroscopy" title=" gas phase spectroscopy"> gas phase spectroscopy</a>, <a href="https://publications.waset.org/abstracts/search?q=IR-UV%20double%20resonance%20spectroscopy" title=" IR-UV double resonance spectroscopy"> IR-UV double resonance spectroscopy</a>, <a href="https://publications.waset.org/abstracts/search?q=laser%20induced%20fluorescence" title=" laser induced fluorescence"> laser induced fluorescence</a>, <a href="https://publications.waset.org/abstracts/search?q=photoionization%20efficiency%20spectroscopy" title=" photoionization efficiency spectroscopy"> photoionization efficiency spectroscopy</a> </p> <a href="https://publications.waset.org/abstracts/171374/27-diazaindole-as-a-photophysical-probe-for-excited-state-hydrogenproton-transfer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/171374.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">75</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">12</span> 2,7-diazaindole as a Potential Photophysical Probe for Excited State Deactivation Processes</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Simran%20Baweja">Simran Baweja</a>, <a href="https://publications.waset.org/abstracts/search?q=Bhavika%20Kalal"> Bhavika Kalal</a>, <a href="https://publications.waset.org/abstracts/search?q=Surajit%20Maity"> Surajit Maity</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Photoinduced tautomerization reactions have been the centre of attention among scientific community over past several decades because of their significance in various biological systems. 7-azaindole (7AI) is considered as a model system for DNA base pairing and to understand the role of such tautomerization reactions in mutations. To the best of our knowledge, extensive studies have been carried on 7-azaindole and its solvent clusters exhibiting proton/ hydrogen transfer in both solution as well as gas phase. Derivatives of above molecule, like 2,7- and 2,6-diazaindoles are proposed to have even better photophysical properties due to the presence of -aza group on the 2nd position. However, there are a few studies in the solution phase which suggest the relevance of these molecules, but there are no experimental studies reported in the gas phase yet. In our current investigation, we present the first gas phase spectroscopic data of 2,7-diazaindole (2,7-DAI) and its solvent cluster (2,7-DAI-H2O). In this, we have employed state-of-the-art laser spectroscopic methods such as fluorescence excitation (LIF), dispersed fluorescence (DF), resonant two-photon ionization time of flight mass spectrometry (2C-R2PI), photoionization efficiency spectroscopy (PIE), IR-UV double resonance spectroscopy i.e. fluorescence-dip infrared spectroscopy (FDIR) and resonant ion-dip infrared spectroscopy (IDIR) to understand the electronic structure of the molecule. The origin band corresponding to S1 ← S0 transition of the bare 2,7-DAI is found to be positioned at 33910 cm-1 whereas the origin band corresponding to S1 ← S0 transition of the 2,7-DAI-H2O is positioned at 33074 cm-1. The red shifted transition in case of solvent cluster suggests the enhanced feasibility of excited state hydrogen/ proton transfer. The ionization potential for the 2,7-DAI molecule is found to be 8.92 eV, which is significantly higher that the previously reported 7AI (8.11 eV) molecule, making it a comparatively complex molecule to study. The ionization potential is reduced by 0.14 eV in case of 2,7-DAI-H2O (8.78 eV) cluster compared to that of 2,7-DAI. Moreover, on comparison with the available literature values of 7AI, we found the origin band of 2,7-DAI and 2,7-DAI-H2O to be red shifted by -729 and -280 cm-1 respectively. The ground and excited state N-H stretching frequencies of the 27DAI molecule were determined using fluorescence-dip infrared spectra (FDIR) and resonant ion dip infrared spectroscopy (IDIR), obtained at 3523 and 3467 cm-1, respectively. The lower value of vNH in the electronic excited state of 27DAI implies the higher acidity of the group compared to the ground state. Moreover, we have done extensive computational analysis, which suggests that the energy barrier in excited state reduces significantly as we increase the number of catalytic solvent molecules (S= H2O, NH3) as well as the polarity of solvent molecules. We found that the ammonia molecule is a better candidate for hydrogen transfer compared to water because of its higher gas-phase basicity. Further studies are underway to understand the excited state dynamics and photochemistry of such N-rich chromophores. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=photoinduced%20tautomerization%20reactions" title="photoinduced tautomerization reactions">photoinduced tautomerization reactions</a>, <a href="https://publications.waset.org/abstracts/search?q=gas%20phse%20spectroscopy" title=" gas phse spectroscopy"> gas phse spectroscopy</a>, <a href="https://publications.waset.org/abstracts/search?q=%29" title=" )"> )</a>, <a href="https://publications.waset.org/abstracts/search?q=IR-UV%20double%20resonance%20spectroscopy" title=" IR-UV double resonance spectroscopy"> IR-UV double resonance spectroscopy</a>, <a href="https://publications.waset.org/abstracts/search?q=resonant%20two-photon%20ionization%20time%20of%20flight%20mass%20spectrometry%20%282C-R2PI%29" title=" resonant two-photon ionization time of flight mass spectrometry (2C-R2PI)"> resonant two-photon ionization time of flight mass spectrometry (2C-R2PI)</a> </p> <a href="https://publications.waset.org/abstracts/171887/27-diazaindole-as-a-potential-photophysical-probe-for-excited-state-deactivation-processes" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/171887.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">86</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">11</span> Quantitative Structure Activity Relationship Model for Predicting the Aromatase Inhibition Activity of 1,2,3-Triazole Derivatives</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=M.%20Ouassaf">M. Ouassaf</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Belaidi"> S. Belaidi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Aromatase is an estrogen biosynthetic enzyme belonging to the cytochrome P450 family, which catalyzes the limiting step in the conversion of androgens to estrogens. As it is relevant for the promotion of tumor cell growth. A set of thirty 1,2,3-triazole derivatives was used in the quantitative structure activity relationship (QSAR) study using regression multiple linear (MLR), We divided the data into two training and testing groups. The results showed a good predictive ability of the MLR model, the models were statistically robust internally (R² = 0.982) and the predictability of the model was tested by several parameters. including external criteria (R²pred = 0.851, CCC = 0.946). The knowledge gained in this study should provide relevant information that contributes to the origins of aromatase inhibitory activity and, therefore, facilitates our ongoing quest for aromatase inhibitors with robust properties. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=aromatase%20inhibitors" title="aromatase inhibitors">aromatase inhibitors</a>, <a href="https://publications.waset.org/abstracts/search?q=QSAR" title=" QSAR"> QSAR</a>, <a href="https://publications.waset.org/abstracts/search?q=MLR" title=" MLR"> MLR</a>, <a href="https://publications.waset.org/abstracts/search?q=1" title=" 1"> 1</a>, <a href="https://publications.waset.org/abstracts/search?q=2" title="2">2</a>, <a href="https://publications.waset.org/abstracts/search?q=3-triazole" title="3-triazole">3-triazole</a> </p> <a href="https://publications.waset.org/abstracts/100877/quantitative-structure-activity-relationship-model-for-predicting-the-aromatase-inhibition-activity-of-123-triazole-derivatives" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/100877.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">115</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">10</span> The White Stork (Ciconia ciconia) in the Wetlands of North East of Algeria</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Aicha%20Beya%20Mammeria">Aicha Beya Mammeria</a>, <a href="https://publications.waset.org/abstracts/search?q=Idir%20Bitam"> Idir Bitam</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Our study focuses on the distribution of the white stork "Ciconia ciconia L. 1758" in the wetlands of El Tarf (North eastern of Algeria): recognized by its remarkable number of breeding pairs, monitoring of nesting, using a GPS has been performed in an attempt to explain the functioning of populations and population strategies for an overall design of its distribution, which has not so far been investigated in this region. Between 2012 and 2013, the number of breeding pairs has increased considerably from 174 in 1996 to 475 in 2007 and 968 in 2013. It should be noted that in the distribution of breeding pairs between 1996 and 2011, there is a significant development since the density of nests increased from 25.22 in 1996 to 84.16 couples/100 km² in 2013. More endemic bread apears in the region, this fluctuation is related to climatic change and changing season. Changes related to local climatic conditions might induce binding conditions for the development of this species. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=white%20stork" title="white stork">white stork</a>, <a href="https://publications.waset.org/abstracts/search?q=Ciconia%20ciconia" title=" Ciconia ciconia"> Ciconia ciconia</a>, <a href="https://publications.waset.org/abstracts/search?q=wetland%20El%20Tarf" title=" wetland El Tarf"> wetland El Tarf</a>, <a href="https://publications.waset.org/abstracts/search?q=northeast%20Algeria" title=" northeast Algeria"> northeast Algeria</a>, <a href="https://publications.waset.org/abstracts/search?q=climatic%20changing" title=" climatic changing"> climatic changing</a>, <a href="https://publications.waset.org/abstracts/search?q=density" title=" density"> density</a> </p> <a href="https://publications.waset.org/abstracts/23717/the-white-stork-ciconia-ciconia-in-the-wetlands-of-north-east-of-algeria" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/23717.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">534</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">9</span> Learning Example of a Biomedical Project from a Real Problem of Muscle Fatigue</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=M.%20Rezki">M. Rezki</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Belaidi"> A. Belaidi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This paper deals with a method of learning to solve a real problem in biomedical engineering from a technical study of muscle fatigue. Electromyography (EMG) is a technique for evaluating and recording the electrical activity produced by skeletal muscles (viewpoint: anatomical and physiological). EMG is used as a diagnostics tool for identifying neuromuscular diseases, assessing low-back pain and muscle fatigue in general. In order to study the EMG signal for detecting fatigue in a muscle, we have taken a real problem which touches the tramway conductor the handle bar. For the study, we have used a typical autonomous platform in order to get signals at real time. In our case study, we were confronted with complex problem to do our experiments in a tram. This type of problem is recurring among students. To teach our students the method to solve this kind of problem, we built a similar system. Through this study, we realized a lot of objectives such as making the equipment for simulation, the study of detection of muscle fatigue and especially how to manage a study of biomedical looking. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=EMG" title="EMG">EMG</a>, <a href="https://publications.waset.org/abstracts/search?q=health%20platform" title=" health platform"> health platform</a>, <a href="https://publications.waset.org/abstracts/search?q=conductor%E2%80%99s%20tram" title=" conductor’s tram"> conductor’s tram</a>, <a href="https://publications.waset.org/abstracts/search?q=muscle%20fatigue" title=" muscle fatigue"> muscle fatigue</a> </p> <a href="https://publications.waset.org/abstracts/48636/learning-example-of-a-biomedical-project-from-a-real-problem-of-muscle-fatigue" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/48636.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">313</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">8</span> Numerical Applications of Tikhonov Regularization for the Fourier Multiplier Operators</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Fethi%20Soltani">Fethi Soltani</a>, <a href="https://publications.waset.org/abstracts/search?q=Adel%20Almarashi"> Adel Almarashi</a>, <a href="https://publications.waset.org/abstracts/search?q=Idir%20Mechai"> Idir Mechai</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Tikhonov regularization and reproducing kernels are the most popular approaches to solve ill-posed problems in computational mathematics and applications. And the Fourier multiplier operators are an essential tool to extend some known linear transforms in Euclidean Fourier analysis, as: Weierstrass transform, Poisson integral, Hilbert transform, Riesz transforms, Bochner-Riesz mean operators, partial Fourier integral, Riesz potential, Bessel potential, etc. Using the theory of reproducing kernels, we construct a simple and efficient representations for some class of Fourier multiplier operators Tm on the Paley-Wiener space Hh. In addition, we give an error estimate formula for the approximation and obtain some convergence results as the parameters and the independent variables approaches zero. Furthermore, using numerical quadrature integration rules to compute single and multiple integrals, we give numerical examples and we write explicitly the extremal function and the corresponding Fourier multiplier operators. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=fourier%20multiplier%20operators" title="fourier multiplier operators">fourier multiplier operators</a>, <a href="https://publications.waset.org/abstracts/search?q=Gauss-Kronrod%20method%20of%20integration" title=" Gauss-Kronrod method of integration"> Gauss-Kronrod method of integration</a>, <a href="https://publications.waset.org/abstracts/search?q=Paley-Wiener%20space" title=" Paley-Wiener space"> Paley-Wiener space</a>, <a href="https://publications.waset.org/abstracts/search?q=Tikhonov%20regularization" title=" Tikhonov regularization"> Tikhonov regularization</a> </p> <a href="https://publications.waset.org/abstracts/38538/numerical-applications-of-tikhonov-regularization-for-the-fourier-multiplier-operators" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/38538.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">318</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7</span> Quantitative Structure-Activity Relationship Modeling of Detoxication Properties of Some 1,2-Dithiole-3-Thione Derivatives</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nadjib%20Melkemi">Nadjib Melkemi</a>, <a href="https://publications.waset.org/abstracts/search?q=Salah%20Belaidi"> Salah Belaidi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Quantitative Structure-Activity Relationship (QSAR) studies have been performed on nineteen molecules of 1,2-dithiole-3-thione analogues. The compounds used are the potent inducers of enzymes involved in the maintenance of reduced glutathione pools as well as phase-2 enzymes important to electrophile detoxication. A multiple linear regression (MLR) procedure was used to design the relationships between molecular descriptor and detoxication properties of the 1,2-dithiole-3-thione derivatives. The predictivity of the model was estimated by cross-validation with the leave-one-out method. Our results suggest a QSAR model based of the following descriptors: qS2, qC3, qC5, qS6, DM, Pol, log P, MV, SAG, HE and EHOMO for the specific activity of quinone reductase; qS1, qS2, qC3, qC4, qC5, qS6, DM, Pol, logP, MV, SAG, HE and EHOMO for the production of growth hormone. To confirm the predictive power of the models, an external set of molecules was used. High correlation between experimental and predicted activity values was observed, indicating the validation and the good quality of the derived QSAR models. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=QSAR" title="QSAR">QSAR</a>, <a href="https://publications.waset.org/abstracts/search?q=quinone%20reductase%20activity" title=" quinone reductase activity"> quinone reductase activity</a>, <a href="https://publications.waset.org/abstracts/search?q=production%20of%20growth%20hormone" title=" production of growth hormone"> production of growth hormone</a>, <a href="https://publications.waset.org/abstracts/search?q=MLR" title=" MLR"> MLR</a> </p> <a href="https://publications.waset.org/abstracts/7137/quantitative-structure-activity-relationship-modeling-of-detoxication-properties-of-some-12-dithiole-3-thione-derivatives" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/7137.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">350</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">6</span> Multisymplectic Geometry and Noether Symmetries for the Field Theories and the Relativistic Mechanics</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=H.%20Loumi-Fergane">H. Loumi-Fergane</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Belaidi"> A. Belaidi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The problem of symmetries in field theory has been analyzed using geometric frameworks, such as the multisymplectic models by using in particular the multivector field formalism. In this paper, we expand the vector fields associated to infinitesimal symmetries which give rise to invariant quantities as Noether currents for classical field theories and relativistic mechanic using the multisymplectic geometry where the Poincaré-Cartan form has thus been greatly simplified using the Second Order Partial Differential Equation (SOPDE) for multi-vector fields verifying Euler equations. These symmetries have been classified naturally according to the construction of the fiber bundle used.  In this work, unlike other works using the analytical method, our geometric model has allowed us firstly to distinguish the angular moments of the gauge field obtained during different transformations while these moments are gathered in a single expression and are obtained during a rotation in the Minkowsky space. Secondly, no conditions are imposed on the Lagrangian of the mechanics with respect to its dependence in time and in q<sup>i</sup>, the currents obtained naturally from the transformations are respectively the energy and the momentum of the system. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=conservation%20laws" title="conservation laws">conservation laws</a>, <a href="https://publications.waset.org/abstracts/search?q=field%20theories" title=" field theories"> field theories</a>, <a href="https://publications.waset.org/abstracts/search?q=multisymplectic%20geometry" title=" multisymplectic geometry"> multisymplectic geometry</a>, <a href="https://publications.waset.org/abstracts/search?q=relativistic%20mechanics" title=" relativistic mechanics"> relativistic mechanics</a> </p> <a href="https://publications.waset.org/abstracts/74108/multisymplectic-geometry-and-noether-symmetries-for-the-field-theories-and-the-relativistic-mechanics" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/74108.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">206</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5</span> Integration of a Load Switch with DC/DC Buck Converter for Power Distribution in Low Cost Educational Nanosatellite</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Bentoutou%20Houari">Bentoutou Houari</a>, <a href="https://publications.waset.org/abstracts/search?q=Boutte%20Aissa"> Boutte Aissa</a>, <a href="https://publications.waset.org/abstracts/search?q=Belaidi%20El%20Yazid"> Belaidi El Yazid</a>, <a href="https://publications.waset.org/abstracts/search?q=Limam%20Lakhdar"> Limam Lakhdar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The integration of a load switch with a DC/DC buck converter using LM2596 for power distribution in low-cost educational nanosatellites is a technique that aims to efficiently manage the power distribution system in these small spacecraft. The converter is based on the LM2596 regulator and designed to step down the input voltage of +16.8V to +12V, +5V, and +3.3V output, which are suitable for the nanosatellite's various subsystems. The load switch is based on MOSFET and is used to turn on or off the power supply to a particular load and protect the nanosatellite from power surges. A prototype of a +12V DC/DC buck converter with a high side load switch has been realized and tested, which meets our requirements and shows a good efficiency of 89%. In addition, the prototype features a capacitor between the source and gate of the MOSFET, which has effectively reduced the inrush current, demonstrating the effectiveness of this approach in reducing surges of current when the load is connected. The output current and voltage were measured at 0.7A and 11.89V, respectively, making this design suitable for use in low-cost educational nanosatellites. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=DC%2FDC%20buck%20converter" title="DC/DC buck converter">DC/DC buck converter</a>, <a href="https://publications.waset.org/abstracts/search?q=load%20switch" title=" load switch"> load switch</a>, <a href="https://publications.waset.org/abstracts/search?q=LM2596" title=" LM2596"> LM2596</a>, <a href="https://publications.waset.org/abstracts/search?q=electrical%20power%20subsystems" title=" electrical power subsystems"> electrical power subsystems</a>, <a href="https://publications.waset.org/abstracts/search?q=nanosatellite" title=" nanosatellite"> nanosatellite</a>, <a href="https://publications.waset.org/abstracts/search?q=inrush%20current" title=" inrush current"> inrush current</a> </p> <a href="https://publications.waset.org/abstracts/166405/integration-of-a-load-switch-with-dcdc-buck-converter-for-power-distribution-in-low-cost-educational-nanosatellite" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/166405.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">101</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4</span> The Effect of Supplementary Cementitious Materials on Fresh and Hardened Properties of Self-Compacting Concretes</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Akram%20Salah%20Eddine%20Belaidi">Akram Salah Eddine Belaidi</a>, <a href="https://publications.waset.org/abstracts/search?q=Said%20Kenai"> Said Kenai</a>, <a href="https://publications.waset.org/abstracts/search?q=El-Hadj%20Kadri"> El-Hadj Kadri</a>, <a href="https://publications.waset.org/abstracts/search?q=Bencha%C3%A2%20Benabed"> Benchaâ Benabed</a>, <a href="https://publications.waset.org/abstracts/search?q=Hamza%20Soualhi"> Hamza Soualhi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Self-compacting concrete (SCC) was developed in the middle of the 1980’s in Japan. SCC flows alone under its dead weight and consolidates itself without any entry of additional compaction energy and without segregation. As an integral part of a SCC, self-compacting mortars (SCM) may serve as a basis for the mix design of concrete since the measurement of the rheological properties of SCCs. This paper discusses the effect of using natural pozzolana (PZ) and marble powder (MP) in two alternative systems ratios PZ/MP = 1 and 1/3 of the performance of the SCC. A total of 11 SCC’s were prepared having a constant water-binder (w/b) ratio of 0.40 and total cementitious materials content of 475 kg/m3. Then, the fresh properties of the mortars were tested for mini-slump flow diameter and mini-V-funnel flow time for SCMs and Slumps flow test, L-Box height ratio, V-Funnel flow time and sieve stability for SCC. Moreover, the development in the compressive strength was determined at 3, 7, 28, 56, and 90 days. Test results have shown that using of ternary blends improved the fresh properties of the mixtures. The compressive strength of SCC at 90 days with 30% of PZ and MP was similar to those of ordinary concrete use in situ. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=self-compacting%20mortar" title="self-compacting mortar">self-compacting mortar</a>, <a href="https://publications.waset.org/abstracts/search?q=self-compacting%20concrete" title=" self-compacting concrete"> self-compacting concrete</a>, <a href="https://publications.waset.org/abstracts/search?q=natural%20pozzolana" title=" natural pozzolana"> natural pozzolana</a>, <a href="https://publications.waset.org/abstracts/search?q=marble%20powder" title=" marble powder"> marble powder</a>, <a href="https://publications.waset.org/abstracts/search?q=rheology" title=" rheology"> rheology</a>, <a href="https://publications.waset.org/abstracts/search?q=compressive%20strength" title=" compressive strength"> compressive strength</a> </p> <a href="https://publications.waset.org/abstracts/14200/the-effect-of-supplementary-cementitious-materials-on-fresh-and-hardened-properties-of-self-compacting-concretes" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/14200.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">375</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> Cannabis Sativa L as Natural Source of Promising Anti-Alzheimer Drug Candidates: A Comprehensive Computational Approach Including Molecular Docking, Molecular Dynamics, Admet and MM-PBSA Studies</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hassan%20Nour">Hassan Nour</a>, <a href="https://publications.waset.org/abstracts/search?q=Nouh%20Mounadi"> Nouh Mounadi</a>, <a href="https://publications.waset.org/abstracts/search?q=Oussama%20Abchir"> Oussama Abchir</a>, <a href="https://publications.waset.org/abstracts/search?q=Belaidi%20Salah"> Belaidi Salah</a>, <a href="https://publications.waset.org/abstracts/search?q=Samir%20Chtita"> Samir Chtita</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Cholinesterase enzymes are biological catalysts essential for the transformation of acetylcholine, which is a neurotransmitter implicated in memory and learning, into acetic acid and choline, altering the neurotransmission process in Alzheimer’s disease patients. Therefore, inhibition of cholinesterase enzymes is a relevant strategy for the symptomatic treatment of Alzheimer’s disease. The current investigation aims to explore potential Cholinesterase (ChE) inhibitors through a comprehensive computational approach. Forty-nine phytoconstituents extracted from Cannabis sativa L were in-silico screened using molecular docking, pharmacokinetic and toxicological analysis to evaluate their possible inhibitory effect towards the cholinesterase enzymes. Two phytoconstituents belonging to cannabinoid derivatives were revealed to be promising candidates for Alzheimer therapy by acting as cholinesterase inhibitors. They have exhibited high binding affinities towards the cholinesterase enzymes and showed their ability to interact with key residues involved in cholinesterase enzymatic activity. In addition, they presented good ADMET profiles allowing them to be promising oral drug candidates. Furthermore, molecular dynamics (MD) simulations were executed to explore their interactions stability under mimetic biological conditions and thus support our findings. To corroborate the docking results, the binding free energy corresponding to the more stable ligand-ChE complexes was re-estimated by applying the MM-PBSA method. MD and MM-PBSA studies affirmed that the ligand-ChE recognition is spontaneous reaction leading to stable complexes. The conducted investigations have led to great findings that would strongly guide the pharmaceutical industries towards the rational development of potent anti-Alzheimer agents. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=alzheimer%E2%80%99s%20disease" title="alzheimer’s disease">alzheimer’s disease</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20docking" title=" molecular docking"> molecular docking</a>, <a href="https://publications.waset.org/abstracts/search?q=cannabis%20sativa%20l" title=" cannabis sativa l"> cannabis sativa l</a>, <a href="https://publications.waset.org/abstracts/search?q=cholinesterase%20inhibitors" title=" cholinesterase inhibitors"> cholinesterase inhibitors</a> </p> <a href="https://publications.waset.org/abstracts/171130/cannabis-sativa-l-as-natural-source-of-promising-anti-alzheimer-drug-candidates-a-comprehensive-computational-approach-including-molecular-docking-molecular-dynamics-admet-and-mm-pbsa-studies" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/171130.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">73</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Cannabis Sativa L as Natural Source of Promising Anti-Alzheimer Drug Candidates: A Comprehensive Computational Approach Including Molecular Docking, Molecular Dynamics, ADMET and MM-PBSA Studies</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hassan%20Nour">Hassan Nour</a>, <a href="https://publications.waset.org/abstracts/search?q=Nouh%20Mounadi"> Nouh Mounadi</a>, <a href="https://publications.waset.org/abstracts/search?q=Oussama%20Abchir"> Oussama Abchir</a>, <a href="https://publications.waset.org/abstracts/search?q=Belaidi%20Salah"> Belaidi Salah</a>, <a href="https://publications.waset.org/abstracts/search?q=Samir%20Chtita"> Samir Chtita</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Cholinesterase enzymes are biological catalysts essential for the transformation of acetylcholine, which is a neurotransmitter implicated in memory and learning, into acetic acid and choline, altering the neurotransmission process in Alzheimer’s disease patients. Therefore, inhibition of cholinesterase enzymes is a relevant strategy for the symptomatic treatment of Alzheimer’s disease. The current investigation aims to explore potential cholinesterase (ChE) inhibitors through a comprehensive computational approach. Forty-nine phytoconstituents extracted from Cannabis sativa L. were in-silico screened using molecular docking and pharmacokinetic and toxicological analysis to evaluate their possible inhibitory effect on the cholinesterase enzymes. Two phytoconstituents belonging to cannabinoid derivatives were revealed to be promising candidates for Alzheimer's therapy by acting as cholinesterase inhibitors. They have exhibited high binding affinities towards the cholinesterase enzymes and showed their ability to interact with key residues involved in cholinesterase enzymatic activity. In addition, they presented good ADMET profiles allowing them to be promising oral drug candidates. Furthermore, molecular dynamics (MD) simulations were executed to explore their interaction stability under mimetic biological conditions and thus support our findings. To corroborate the docking results, the binding free energy corresponding to the more stable ligand-ChE complexes was re-estimated by applying the MM-PBSA method. MD and MM-PBSA studies affirmed that the ligand-ChE recognition is a spontaneous reaction leading to stable complexes. The conducted investigations have led to great findings that would strongly guide the pharmaceutical industries toward the rational development of potent anti-Alzheimer agents. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Alzheimer%E2%80%99s%20disease" title="Alzheimer’s disease">Alzheimer’s disease</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20docking" title=" molecular docking"> molecular docking</a>, <a href="https://publications.waset.org/abstracts/search?q=Cannabis%20sativa%20L." title=" Cannabis sativa L."> Cannabis sativa L.</a>, <a href="https://publications.waset.org/abstracts/search?q=cholinesterase%20inhibitors" title=" cholinesterase inhibitors"> cholinesterase inhibitors</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20dynamics" title=" molecular dynamics"> molecular dynamics</a>, <a href="https://publications.waset.org/abstracts/search?q=ADMET" title=" ADMET"> ADMET</a>, <a href="https://publications.waset.org/abstracts/search?q=MM-PBSA" title=" MM-PBSA"> MM-PBSA</a> </p> <a href="https://publications.waset.org/abstracts/171128/cannabis-sativa-l-as-natural-source-of-promising-anti-alzheimer-drug-candidates-a-comprehensive-computational-approach-including-molecular-docking-molecular-dynamics-admet-and-mm-pbsa-studies" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/171128.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">83</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Contribution of Artificial Intelligence in the Studies of Natural Compounds Against SARS-COV-2</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Salah%20Belaidi">Salah Belaidi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> We have carried out extensive and in-depth research to search for bioactive compounds based on Algerian plants. A selection of 50 ligands from Algerian medicinal plants. Several compounds used in herbal medicine have been drawn using Marvin Sketch software. We determined the three-dimensional structures of the ligands with the MMFF94 force field in order to prepare these ligands for molecular docking. The 3D protein structure of the SARS-CoV-2 main protease was taken from the Protein Data Bank. We used AutoDockVina software to apply molecular docking. The hydrogen atoms were added during the molecular docking process, and all the twist bonds of the ligands were added using the (ligand) module in the AutoDock software. The COVID-19 main protease (Mpro) is a key enzyme that plays a vital role in viral transcription and mediating replication, so it is a very attractive drug target for SARS-CoV-2. In this work, an evaluation was carried out on the biologically active compounds present in these selected medicinal plants as effective inhibitors of the protease enzyme of COVID-19, with an in-depth computational calculation of the molecular docking using the Autodock Vina software. The top 7 ligands: Phloroglucinol, Afzelin, Myricetin-3-O- rutinosidTricin 7-neohesperidoside, Silybin, Silychristinthat and Kaempferol are selected among the 50 molecules studied which are Algerian medicinal plants, whose selection is based on the best binding energy which is relatively low compared to the reference molecule with binding affinities of -9.3, -9.3, -9, -8.9, -8 .5, 8.3 and -8.3 kcal mol-1 respectively. Then, we analyzed the ADME properties of the best7 ligands using the web server SwissADME. Two ligands (Silybin, Silychristin) were found to be potential candidates for the discovery and design of novel drug inhibitors of the protease enzyme of SARS-CoV-2. The stability of the two ligands in complexing with the Mpro protease was validated by molecular dynamics simulation; they revealed a stable trajectory in both techniques, RMSD and RMSF, by showing molecular properties with coherent interactions in molecular dynamics simulations. Finally, we conclude that the Silybin ligand forms a more stable complex with the Mpro protease compared to the Silychristin ligand. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=COVID-19" title="COVID-19">COVID-19</a>, <a href="https://publications.waset.org/abstracts/search?q=medicinal%20plants" title=" medicinal plants"> medicinal plants</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20docking" title=" molecular docking"> molecular docking</a>, <a href="https://publications.waset.org/abstracts/search?q=ADME%20properties" title=" ADME properties"> ADME properties</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20dynamics" title=" molecular dynamics"> molecular dynamics</a> </p> <a href="https://publications.waset.org/abstracts/188747/contribution-of-artificial-intelligence-in-the-studies-of-natural-compounds-against-sars-cov-2" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/188747.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">34</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Account <li><a href="https://waset.org/profile">My Account</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Explore <li><a href="https://waset.org/disciplines">Disciplines</a></li> <li><a href="https://waset.org/conferences">Conferences</a></li> <li><a href="https://waset.org/conference-programs">Conference Program</a></li> <li><a href="https://waset.org/committees">Committees</a></li> <li><a href="https://publications.waset.org">Publications</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Research <li><a href="https://publications.waset.org/abstracts">Abstracts</a></li> <li><a href="https://publications.waset.org">Periodicals</a></li> <li><a href="https://publications.waset.org/archive">Archive</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Open Science <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Philosophy.pdf">Open Science Philosophy</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Award.pdf">Open Science Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Society-Open-Science-and-Open-Innovation.pdf">Open Innovation</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Postdoctoral-Fellowship-Award.pdf">Postdoctoral Fellowship Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Scholarly-Research-Review.pdf">Scholarly Research Review</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Support <li><a href="https://waset.org/page/support">Support</a></li> <li><a href="https://waset.org/profile/messages/create">Contact Us</a></li> <li><a href="https://waset.org/profile/messages/create">Report Abuse</a></li> </ul> </div> </div> </div> </div> </div> <div class="container text-center"> <hr style="margin-top:0;margin-bottom:.3rem;"> <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" class="text-muted small">Creative Commons Attribution 4.0 International License</a> <div id="copy" class="mt-2">© 2024 World Academy of Science, Engineering and Technology</div> </div> </footer> <a href="javascript:" id="return-to-top"><i class="fas fa-arrow-up"></i></a> <div class="modal" id="modal-template"> <div class="modal-dialog"> <div class="modal-content"> <div class="row m-0 mt-1"> <div class="col-md-12"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"><span aria-hidden="true">×</span></button> </div> </div> <div class="modal-body"></div> </div> </div> </div> <script src="https://cdn.waset.org/static/plugins/jquery-3.3.1.min.js"></script> <script src="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/js/bootstrap.bundle.min.js"></script> <script src="https://cdn.waset.org/static/js/site.js?v=150220211556"></script> <script> jQuery(document).ready(function() { /*jQuery.get("https://publications.waset.org/xhr/user-menu", function (response) { jQuery('#mainNavMenu').append(response); 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