कैंसर विज्ञान एवं चिकित्सा | 9

<!doctype html> <html lang="hi"> <head> <meta charset="utf-8"> <meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"> <title>कैंसर विज्ञान एवं चिकित्सा | 9 | 2017</title> <meta name="keywords" content="कैंसर विज्ञान एवं चिकित्सा journal articles, 9 | 2017"/> <meta name="description" content="कैंसर विज्ञान एवं चिकित्सा, 9 | 2017."/>  <link rel="alternate" href="https://hindi.hilarispublisher.com/archive/jcst-volume-9-issue-7-year-2017.html" hreflang="hi-IN"/> <link rel="canonical" href="https://hindi.hilarispublisher.com/archive/jcst-volume-9-issue-7-year-2017.html"> <meta name="google-site-verification" content="oWMEafdcaiOzLHBHrMgGBwtQrvUtl_diAl2cELZt1Ks" /> <meta name="ROBOTS" content="INDEX,FOLLOW"> <meta name="googlebot" content="INDEX,FOLLOW"> <link rel="stylesheet" href="https://stackpath.bootstrapcdn.com/bootstrap/4.4.1/css/bootstrap.min.css"> <link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.11.2/css/all.min.css" /> <link rel="stylesheet" href="https://maxcdn.bootstrapcdn.com/font-awesome/4.3.0/css/font-awesome.min.css"> <link href="https://fonts.googleapis.com/icon?family=Material+Icons" rel="stylesheet"> <link href="https://fonts.googleapis.com/css?family=Roboto:100,100i,300,300i,400,400i,500,500i,700,700i,900,900i&display=swap" rel="stylesheet">  <link rel="stylesheet" href="https://cdn.jsdelivr.net/npm/bootstrap-select@1.13.9/dist/css/bootstrap-select.min.css"> <link rel="stylesheet" href="/assets/css/owl.carousel.min.css"> <link rel="stylesheet" href="/assets/css/owl.theme.default.min.css"> <link rel="stylesheet" href="/assets/css/jquery.mCustomScrollbar.min.css"> <link rel="stylesheet" href="/assets/css/global.css"> <link rel="stylesheet" href="/assets/css/styles.css"> <link rel="stylesheet" href="/assets/css/custom.css"> <link rel="stylesheet" href="/assets/css/author.css"> <link rel="stylesheet" href="/assets/css/coolautosuggest.css"> <link rel="icon" href="/assets/img/favicon.ico" type="image/gif" sizes="16x16">  <script async src="https://www.googletagmanager.com/gtag/js?id=UA-156021785-1"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-BJY2BWFECQ'); </script></head> <body> <nav class="navbar navbar-expand-lg navbar-light bg-light py-3"> <div class="container"> <a class="navbar-brand d-smd-none" href="https://hindi.hilarispublisher.com/" title="यहाँ क्लिक करें"><img src="/assets/img/hilaris-publisher.svg" alt=".." title="यहाँ क्लिक करें" height="40px"></a> <button class="navbar-toggler" type="button" data-toggle="collapse" data-target="#navbarJrnlMain" aria-controls="navbarJrnlMain" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="collapse navbar-collapse" id="navbarJrnlMain"> <div class="navbar-nav mr-auto"> <a class="nav-item nav-link" href="https://hindi.hilarispublisher.com/" title="यहाँ क्लिक करें">घर</a> <a class="nav-item nav-link" href="https://hindi.hilarispublisher.com/open-access-journals.html" title="यहाँ क्लिक करें">पत्रिकाओं</a> <div class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="Guidelines" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">दिशानिर्देश और नीतियां </a> <div class="dropdown-menu" aria-labelledby="Guidelines"> <a class="dropdown-item" href="https://hindi.hilarispublisher.com/editorial-policies.html" title="Editorial Policies">संपादकीय नीतियाँ</a> <a class="dropdown-item" href="https://hindi.hilarispublisher.com/submit-manuscript.html" title="Online Submission">ऑनलाइन सबमिशन</a> <a class="dropdown-item" href="https://hindi.hilarispublisher.com/manuscript-guidelines.html" title="Manuscript Guidelines">पांडुलिपि दिशानिर्देश</a> <a class="dropdown-item" href="https://hindi.hilarispublisher.com/policies.html" title="Policies">नीतियों</a> <a class="dropdown-item" href="https://hindi.hilarispublisher.com/publication-ethics.html" title="Publication ethics">प्रकाशन नैतिकता</a> <a class="dropdown-item" href="https://hindi.hilarispublisher.com/reviewers.html" title="Reviewers">समीक्षक</a> <a class="dropdown-item" href="https://hindi.hilarispublisher.com/terms-conditions.html" title="Terms and Conditions">नियम और शर्तें</a> </div> </div> <div class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="Services" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">सेवाएं </a> <div class="dropdown-menu" aria-labelledby="Services"> <a class="dropdown-item" href="https://hindi.hilarispublisher.com/advertisement.html" title="Advertisement">विज्ञापन</a> <a class="dropdown-item" href="https://hindi.hilarispublisher.com/membership.html" title="Membership">सदस्यता</a> <a class="dropdown-item" href="https://hindi.hilarispublisher.com/reprints.html" title="Reprints">रीप्रिंट</a> <a class="dropdown-item" href="https://hindi.hilarispublisher.com/subscription.html" title="Subscription"> अंशदान</a> </div> </div>  <a class="nav-item nav-link" href="https://hindi.hilarispublisher.com/conferences.html" title="Conferences">सम्मेलन</a> <a class="nav-item nav-link" href="https://hindi.hilarispublisher.com/contact-us.html" title="Contact">संपर्क करें</a> </div>  </div> </div> </nav> <nav class="navbar navbar-expand-lg navbar-dark bg-primary p-0 mb-3 nav-links-mobile-view"> <div class="container mx-3 mx-sm-auto"> <a class="navbar-brand d-block d-sm-none" href="#">जर्नल मेनू</a> <button class="navbar-toggler" type="button" data-toggle="collapse" data-target="#navbarJrnl" aria-controls="navbarJrnl" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="collapse navbar-collapse" id="navbarJrnl"> <div class="navbar-nav mr-auto"> <a class="nav-item nav-link" href="https://hindi.hilarispublisher.com/cancer-science-therapy.html" title="Journal Home"><i class="fas fa-home pr-2"></i> पत्रिका</a> <div class="nav-item dropdown"> <a class="nav-link dropdown-toggle " href="#" id="EditorialPanel" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">लेखकों के लिए निर्देश</a> <div class="dropdown-menu" aria-labelledby="EditorialPanel"> <a class="dropdown-item" href="https://hindi.hilarispublisher.com/cancer-science-therapy/instructionsforauthors.html" title="यहाँ क्लिक करें">लेखकों के लिए निर्देश</a> <a class="dropdown-item" href="https://hindi.hilarispublisher.com/cancer-science-therapy/aim-and-scope.html" title="यहाँ क्लिक करें">उद्देश्य और दायरा</a> <a class="dropdown-item" href="https://hindi.hilarispublisher.com/cancer-science-therapy/ethical-malpractices.html" title="यहाँ क्लिक करें">प्रकाशन नैतिकता और कदाचार बयान</a> </div> </div> <a class="nav-link " href="https://hindi.hilarispublisher.com/cancer-science-therapy/submit-manuscript.html" title="यहाँ क्लिक करें">पांडुलिपि जमा करें</a> <a class="nav-link " href="https://hindi.hilarispublisher.com/cancer-science-therapy/archive.html" title="यहाँ क्लिक करें">पुरालेख</a> <a class="nav-link " href="https://hindi.hilarispublisher.com/cancer-science-therapy/guidelines.html" title="यहाँ क्लिक करें">दिशा-निर्देश</a> <a class="nav-item nav-link" href="https://hindi.hilarispublisher.com/cancer-science-therapy/contact.html" title="यहाँ क्लिक करें">संपर्क</a> </div> </div> </div> </nav> <header class="container py-3"> <div class="row align-items-start"> <div class="col-lg-1 col-md-1 d-none d-sm-block"> <img src="https://www.hilarispublisher.com/admin/flyers/Journal-of-Cancer-Science--Therapy-flyer.jpg" alt=".." title="यहाँ क्लिक करें" class="img-fluid"> </div> <div class="col-lg col-md"> <h1 class="h2 text-primary">कैंसर विज्ञान एवं चिकित्सा</h1> <div class="row"> <div class="col"> <p class="mb-1">आईएसएसएन: 1948-5956 </p> </div> <div class="col"> खुला एक्सेस </div> <div class="nav-item dropdown multi_lang j_multi_lang"> <a class="nav-link dropdown-toggle" href="#" id="multi_lang" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">Language</a> <div class="dropdown-menu" aria-labelledby=""> <a class="dropdown-item" href="https://www.hilarispublisher.com/archive/jcst-volume-9-issue-7-year-2017.html" title="English"> <img src="https://www.hilarispublisher.com/admin/flags/usa.png">English </a> <a class="dropdown-item" href="https://spanish.hilarispublisher.com/archive/jcst-volume-9-issue-7-year-2017.html" title="Spanish"> <img src="https://www.hilarispublisher.com/admin/flags/spain.png">Spanish </a> <a class="dropdown-item" href="https://chinese.hilarispublisher.com/archive/jcst-volume-9-issue-7-year-2017.html" title="Chinese"> <img src="https://www.hilarispublisher.com/admin/flags/china.png">Chinese </a> <a class="dropdown-item" href="https://russian.hilarispublisher.com/archive/jcst-volume-9-issue-7-year-2017.html" title="Russian"> <img src="https://www.hilarispublisher.com/admin/flags/russia.png">Russian </a> <a class="dropdown-item" href="https://german.hilarispublisher.com/archive/jcst-volume-9-issue-7-year-2017.html" title="German"> <img src="https://www.hilarispublisher.com/admin/flags/germany.png">German </a> <a class="dropdown-item" href="https://french.hilarispublisher.com/archive/jcst-volume-9-issue-7-year-2017.html" title="French"> <img src="https://www.hilarispublisher.com/admin/flags/france.png">French </a> <a class="dropdown-item" href="https://japanese.hilarispublisher.com/archive/jcst-volume-9-issue-7-year-2017.html" title="Japanese"> <img src="https://www.hilarispublisher.com/admin/flags/japan.png">Japanese </a> <a class="dropdown-item" href="https://portuguese.hilarispublisher.com/archive/jcst-volume-9-issue-7-year-2017.html" title="Portuguese"> <img src="https://www.hilarispublisher.com/admin/flags/portugal.png">Portuguese </a> <a class="dropdown-item" href="https://telugu.hilarispublisher.com/archive/jcst-volume-9-issue-7-year-2017.html" title="Telugu"> <img src="https://www.hilarispublisher.com/admin/flags/india.png">Telugu </a> <a class="dropdown-item" href="https://tamil.hilarispublisher.com/archive/jcst-volume-9-issue-7-year-2017.html" title="Tamil"> <img src="https://www.hilarispublisher.com/admin/flags/india.png">Tamil </a> </div> </div> </div> </div> <div class="col-lg-3 col-md-4"> <div class="card bg-amber-400 border-0"> <div class="card-body p-2 d-flex align-items-center"> पांडुलिपि जमा करें <a class="animate-icon mx-3 stretched-link" href="https://www.scholarscentral.org/submissions/cancer-science-therapy.html" title="यहाँ क्लिक करें" target="_blank"> <span target="_blank" class="animate-icon-horizontal"> <i class="material-icons animate-icon-horizontal-wrap animate-icon-left-to-right">arrow_forward</i> <i class="material-icons animate-icon-horizontal-wrap animate-icon-left-to-right">arrow_forward</i> </span> </a> <img src="/assets/img/manuscript.svg" alt=".." width="50"> </div> </div> <div class="mt-2 cu_whatsapp"> </div> </div> </div> </header> <section class="container"> <div class="row"> <div class="col-sm"> <h2 class="text-primary font-size-6 my-3 border-bottom-2 border-yellow-900 pb-2">आयतन 9, मुद्दा 7 (2017)</h2> <div class="border-bottom-1 py-2"> <div class="d-flex w-100 justify-content-between mb-1"> <span class="align-self-center"> मामला का बिबरानी </span> </div> <h3 class="mb-2 font-size-4"><a href="https://hindi.hilarispublisher.com/abstract/giant-cell-tumor-of-soft-tissues-a-case-report-and-review-of-literature-40865.html" title="Giant Cell Tumor of Soft Tissues: A Case Report and Review of Literature">Giant Cell Tumor of Soft Tissues: A Case Report and Review of Literature</a></h3> <p class="mb-2 font-size-3 text-muted"> <i class="fas fa-user"></i> Amina Mokrani, Fatma Guermazi*, Yosra Yahyaoui, Lina Hmida, Raoudha Doghri, Mouna Ayadi, Meddeb Khedija, Feriel Letaief, Nesrine Chraiet, Henda Raies, Karima Mrad and Amal Mezlini </p> <div class="row justify-content-between align-items-center"> <div class="col pl-0"> <a class="btn btn-link" data-toggle="collapse" href="#collapseAbstract327882" role="button" aria-expanded="false" aria-controls="collapseAbstract"> अमूर्त </a> </div> <div class="col-sm-auto"> <nav class="nav a-mx-2"> <a href="https://hindi.hilarispublisher.com/abstract/giant-cell-tumor-of-soft-tissues-a-case-report-and-review-of-literature-40865.html" title="यहाँ क्लिक करें" class="card-link border-bottom-2 yellow-900 border-yellow-900"><i class="fas fa-file-alt fa-lg"></i> अमूर्त</a> </nav> </div> </div> <div class="collapse" id="collapseAbstract327882"> <div class="card card-body p-2 bg-light"><p><strong>Background:</strong> Primary giant cell tumor (GCT) of soft tissue (GCTST) is an extremely rare slow-growing entity bearing a high similarity to conventional bone TCG (GCTB). The term, malignant tumor of giant cells of soft tissues have been reserved for histologically high-grade lesions. Although the gold standard remains surgical carcinological resection, bisphosphonates are beginning to prove their benefit in the treatment of GCTST.</p> <p><strong>Results and Discussion:</strong> A 37-year-old man came to the outpatient department of medical oncology with a painful swelling arising from his right elbow. Magnetic resonance imaging (MRI) of the right elbow was done and revealed a 19 cm × 7 cm, T1 and T2 hypointense lesion with significant postcontrast enhancement of calcified tissue nodules, distance extension report was negative. An echo-guided biopsy of the right elbow was performed. The anatomopathological examination showed a poorly delimited encapsulated tumor proliferation composed of sheets of histiocytic cells admixed with multinucleated giant cells dispersed uniformly among this tumor. Cells were embedded in a richly vascularized tissue. No significant nuclear pleomorphism or mitotic activity was appreciated. There were focal areas of osseous metaplasia. On the basis of these date, the diagnosis of giant cell tumor of low malignant potential was retained. Due to its intra-articular extension, the mass was judged unresecable. The case was discussed in a multidisciplinary consultation meeting indicating medical treatment with zoledronic acid given the unavailability of denosumab. After 8 monthly injections of zoledronic acid, a control imaging of the right elbow and forearm concluded to tumor stability.</p> <p><strong>Conclusion:</strong> GCTST is a slow-growing tumor known as soft tissue tumor. Numerous studies show the role of bisphosphonates when complete surgical excision cannot be performed. Further studies are needed to establish a standardized treatment protocol particularly in the context of inoperable large primary GCTST.</p> </div> </div> </div> <div class="border-bottom-1 py-2"> <div class="d-flex w-100 justify-content-between mb-1"> <span class="align-self-center"> शोध आलेख </span> </div> <h3 class="mb-2 font-size-4"><a href="https://hindi.hilarispublisher.com/abstract/sociodemographic-factors-associated-with-advanced-stage-of-cervicalcancer-at-diagnosis-in-kenyatta-national-hospital-ken-40864.html" title="Socio-Demographic Factors Associated with Advanced Stage of Cervical Cancer at Diagnosis in Kenyatta National Hospital, Kenya: A Cross Sectional Study">Socio-Demographic Factors Associated with Advanced Stage of Cervical Cancer at Diagnosis in Kenyatta National Hospital, Kenya: A Cross Sectional Study</a></h3> <p class="mb-2 font-size-3 text-muted"> <i class="fas fa-user"></i> Kirema Makena Frida, Wagoro Miriam Carole Atieno and Michael Habtu </p> <div class="row justify-content-between align-items-center"> <div class="col pl-0"> <a class="btn btn-link" data-toggle="collapse" href="#collapseAbstract327881" role="button" aria-expanded="false" aria-controls="collapseAbstract"> अमूर्त </a> </div> <div class="col-sm-auto"> <nav class="nav a-mx-2"> <a href="https://hindi.hilarispublisher.com/abstract/sociodemographic-factors-associated-with-advanced-stage-of-cervicalcancer-at-diagnosis-in-kenyatta-national-hospital-ken-40864.html" title="यहाँ क्लिक करें" class="card-link border-bottom-2 yellow-900 border-yellow-900"><i class="fas fa-file-alt fa-lg"></i> अमूर्त</a> </nav> </div> </div> <div class="collapse" id="collapseAbstract327881"> <div class="card card-body p-2 bg-light"><p>Background: Cervical cancer is the most common and leading cause of deaths due to cancer among women in Kenya. Early detection is necessary for initiation of treatments to prevent deaths. Identification of factors that contribute to advanced stage of cervical cancer is the first step towards early detection. Objectives: To determine socio-demographic factors associated with advanced stage of cervical cancer at diagnosis in Kenyatta National Hospital. Materials and methods:A cross-sectional study of 152 women with a histological proven cervical cancer was conducted at Kenyatta National Hospital. The women were selected using random sampling method. Information on demographic characteristics and stage of cervical cancer were abstracted retrospectively by auditing patients’ records from January 2014 to June 2014. Stages I and II were classified as ‘early stage’ and stages III and IV as ‘advanced stage’. Chi-square test (p-value<0.05) was used to determine association between advanced stage of cervical cancer and socio-demographic characteristics. Multiple logistic regression analysis was performed to determine the independent factors associated with advanced stage of cervical cancer at diagnosis. Results: Out of 152 patients with cervical cancer, 53.9% had advanced stage of cancer at diagnosis. Following multiple logistic regression analysis, the following factors were independently associated with advanced stage of cervical cancer: older age (50 to 75 years) (AOR=4.25; 95% CI=1.08-16.75; P=0.039), being single (AOR=2.28; 95% CI=1.03-5.06; P=0.043), never attended school (AOR=5.91; 95% CI=1.96-17.78; P=0.002), attended primary school (AOR=4.13; 95% CI=1.60-10.63; P=0.003) and HIV positive women (AOR=2.86; 95% CI=1.25-6.59; P=0.013). Conclusion:More than half of the patients presented with advanced stage of cervical cancer at diagnosis. None/low level of education, old age, being single and HIV infection were associated with advanced stage of cancer at diagnosis. Regular cervical cancer screening targeting these women could reduce advanced stage of cervical cancer at diagnosis.</p> </div> </div> </div> <div class="border-bottom-1 py-2"> <div class="d-flex w-100 justify-content-between mb-1"> <span class="align-self-center"> शोध आलेख </span> </div> <h3 class="mb-2 font-size-4"><a href="https://hindi.hilarispublisher.com/abstract/the-influence-of-c936t-gene-in-wild-of-the-vascular-endothelial-growthfactor-and-biochemical-variants-analysis-for-alpha-40863.html" title="The Influence of C936T Gene in Wild of the Vascular Endothelial Growth Factor and Biochemical Variants Analysis for Alpha-Fetoprotein in Hepatocellular Carcinoma Patients in Egypt">The Influence of C936T Gene in Wild of the Vascular Endothelial Growth Factor and Biochemical Variants Analysis for Alpha-Fetoprotein in Hepatocellular Carcinoma Patients in Egypt</a></h3> <p class="mb-2 font-size-3 text-muted"> <i class="fas fa-user"></i> Khaled El-Khashab AE, Soha Hamdy M*, Gama Tamam H, Sahar Soliman M and Asmaa Rady AM </p> <div class="row justify-content-between align-items-center"> <div class="col pl-0"> <a class="btn btn-link" data-toggle="collapse" href="#collapseAbstract327880" role="button" aria-expanded="false" aria-controls="collapseAbstract"> अमूर्त </a> </div> <div class="col-sm-auto"> <nav class="nav a-mx-2"> <a href="https://hindi.hilarispublisher.com/abstract/the-influence-of-c936t-gene-in-wild-of-the-vascular-endothelial-growthfactor-and-biochemical-variants-analysis-for-alpha-40863.html" title="यहाँ क्लिक करें" class="card-link border-bottom-2 yellow-900 border-yellow-900"><i class="fas fa-file-alt fa-lg"></i> अमूर्त</a> </nav> </div> </div> <div class="collapse" id="collapseAbstract327880"> <div class="card card-body p-2 bg-light"><p>Hepatocellular carcinoma (HCC) is one of the most frequent malignant tumors. It is important to detect disease and recurrence at its earlier period. The aim of this study was to evaluate the influence of the C936T polymorphism of the VEGF and Alfa feto-Protein (AFP) on Hepatocellular carcinoma (HCC), Hepatitis C Virus (HCV) and control groups. Also, estimation of serum AFP and correlation with other parameters was studied. In this study was included 75 subjects, 25 patients with HCV, 25 patients with confirmed HCC and 25 healthy volunteers were subjected to abdominal ultrasonography, AFP and VEGF were assessed. The statistical analysis will include the Fisher exact test, T test and the multivariate regression, with significance level P<0.05 (AU). The result has showed that Serum level of AFP was significantly higher in HCC group when compared with control group and There was a nonsignificant increase in serum (AFP) level in the untreated HCV infected group compared to control group and also there was a nonsignificant increase in serum (AFP) activity in the HCC group compared to untreated HCV infected group with a (P value = 0.203). the influence of the C936T polymorphism of the VEGF distribution of the studied groups showing that Positive gene have higher incidence of HCV and HCC infection than Negative gene, when compared to control group. Sensitivity and specificity of markers in diagnosis of HCC were 52% and 40% respectively for AFP using a cutoff value of 3.39 ng/ml. VEGF may be useful marker for detection of HCC in addition to traditional markers.</p> </div> </div> </div> <div class="border-bottom-1 py-2"> <div class="d-flex w-100 justify-content-between mb-1"> <span class="align-self-center"> शोध आलेख </span> </div> <h3 class="mb-2 font-size-4"><a href="https://hindi.hilarispublisher.com/abstract/synthesis-and-biological-evaluations-of-ring-substitutedtetrahydroisoquinolines-thiqs-as-antibreast-cancer-agents-40822.html" title="Synthesis and Biological Evaluations of Ring Substituted Tetrahydroisoquinolines (THIQs) as Anti-Breast Cancer Agents">Synthesis and Biological Evaluations of Ring Substituted Tetrahydroisoquinolines (THIQs) as Anti-Breast Cancer Agents</a></h3> <p class="mb-2 font-size-3 text-muted"> <i class="fas fa-user"></i> Suresh VK Eyunni, Madhavi Gangapuram, Bereket Mochona, Nelly Mateeva and Kinfe K Redda </p> <div class="row justify-content-between align-items-center"> <div class="col pl-0"> <a class="btn btn-link" data-toggle="collapse" href="#collapseAbstract327844" role="button" aria-expanded="false" aria-controls="collapseAbstract"> अमूर्त </a> </div> <div class="col-sm-auto"> <nav class="nav a-mx-2"> <a href="https://hindi.hilarispublisher.com/abstract/synthesis-and-biological-evaluations-of-ring-substitutedtetrahydroisoquinolines-thiqs-as-antibreast-cancer-agents-40822.html" title="यहाँ क्लिक करें" class="card-link border-bottom-2 yellow-900 border-yellow-900"><i class="fas fa-file-alt fa-lg"></i> अमूर्त</a> </nav> </div> </div> <div class="collapse" id="collapseAbstract327844"> <div class="card card-body p-2 bg-light"><p>Breast cancer is a leading cause of mortality among women, resulting in more than half a million deaths worldwide every year. Although chemotherapeutic drugs remain the main stay of cancer treatment, it is observed that toxicity to normal cells poses a limitation to their therapeutic values. Moreover, the patient recovery rate from advanced breast cancer by chemotherapy is still unacceptably low. Tetrahydroisoqinoline derivatives (THIQs) were reported to act as selective subtype estrogen receptor antagonists/agonists and may serve as potential therapeutic agents for breast cancer. In continuation of previous work we systematically synthesized and characterized the tetrahydroisoquinoline (THIQs) analogs. <em>In-vitro</em> antiproliferative activity of new substituted tetrahydroisoquinoline analogs were evaluated against human ER (+) <em>MCF-7</em> (breast), ER (−) <em>MDA-MB-231</em> (breast) and Ishikawa (endometrial) cancer cell lines using the CellTiter-Glo luminescent cell viability assay. The most active compounds obtained in this study were 2b, 2i, and 3 g as demonstrated by their activity (IC<sub>50</sub>=0.2 μg/mL, 0.08 μg/mL; 0.61 μg/ mL, 0.09 μg/mL; 0.25 μg/mL, 0.11 μg/mL) against <em>MCF-7</em> and Ishikawa cell lines respectively, in comparison to Tamoxifen activity (IC<sub>50</sub>=3.99 μg/mL, 7.87 μg/ml). The newly synthesized molecules were docked in the active sites of the ER-α (PDB: 3ERT), ER-β (PDB: 1QKN) and alpha-beta tubulin taxol complex (1JFF) crystal structures to determine the probable binding modes (bioactive conformations) of the active compounds.</p></div> </div> </div> <div class="border-bottom-1 py-2"> <div class="d-flex w-100 justify-content-between mb-1"> <span class="align-self-center"> शोध आलेख </span> </div> <h3 class="mb-2 font-size-4"><a href="https://hindi.hilarispublisher.com/abstract/strategic-perspectives-on-improved-antitumor-drug-effects-incombination-with-clinically-equivalent-or-lower-concentratio-40821.html" title="Strategic Perspectives on Improved Anti-Tumor Drug Effects in Combination with Clinically Equivalent or Lower Concentrations of Epigenetic Modifiers, DNA Methyltransferase Inhibitors, and Histone Deacetylase Inhibitors">Strategic Perspectives on Improved Anti-Tumor Drug Effects in Combination with Clinically Equivalent or Lower Concentrations of Epigenetic Modifiers, DNA Methyltransferase Inhibitors, and Histone Deacetylase Inhibitors</a></h3> <p class="mb-2 font-size-3 text-muted"> <i class="fas fa-user"></i> Shuko Hakata, Kouji Okada, Jun Terashima, Toshie Gamou, Wataru Habano and Shogo Ozawa </p> <div class="row justify-content-between align-items-center"> <div class="col pl-0"> <a class="btn btn-link" data-toggle="collapse" href="#collapseAbstract327843" role="button" aria-expanded="false" aria-controls="collapseAbstract"> अमूर्त </a> </div> <div class="col-sm-auto"> <nav class="nav a-mx-2"> <a href="https://hindi.hilarispublisher.com/abstract/strategic-perspectives-on-improved-antitumor-drug-effects-incombination-with-clinically-equivalent-or-lower-concentratio-40821.html" title="यहाँ क्लिक करें" class="card-link border-bottom-2 yellow-900 border-yellow-900"><i class="fas fa-file-alt fa-lg"></i> अमूर्त</a> </nav> </div> </div> <div class="collapse" id="collapseAbstract327843"> <div class="card card-body p-2 bg-light"><p>The aim of this research is to facilitate the pursuit of improved chemotherapeutic drugs in combination with epigenetic modifiers. Both in vitro studies and a clinical study have described the combinations of DNA methyltransferase inhibitors with irinotecan and histone deacetylase inhibitors with 5-fluorouracil or gemcitabine to enhance their anti-cancer activities. The molecular mechanisms involved in the potentiation of anti-tumor activities were apoptosis regulation, cellular metabolism, DNA topoisomerase-I upregulation, cell-cell adhesion, regulation of transcription (DNA-templated), DNA repair, and the PI3K/AKT signaling pathway. More importantly, the priming effects and long-lasting effects induced by DNA methyltransferase inhibitors, when applied as a pretreatment, sensitized cancer cells to subsequent anti-cancer drug treatments. The combinations of 5-fluorouracil and gemcitabine with histone deacetylase inhibitors (depsipeptide and valproic acid, respectively), increased the expression of major histocompatibility complex class II, which may warrant further investigation for possible accurate biomarkers and therapeutic targets. As valproic acid downregulated histone deacetylase in patients recruited in a clinical phase I/II study, the activity of valproic acid may be associated with the enhanced anti-tumor activity in combination with 5-fluorouracil. This research provides a positive perspective on the combination therapy of anticancer drugs with epigenetic modifiers.</p> </div> </div> </div> </div> <div class="col-12 col-sm-3">  <div class="mb-3"> <h4>जर्नल हाइलाइट्स</h4> <nav class="nav flex-column scrollbar a-pl-0" style="max-height:50vh;"> <a href="https://hindi.hilarispublisher.com/scholarly/pancreatic-cancer-journals-articles-ppts-list-2296.html" class="nav-link" title="अग्न्याशय का कैंसर" title="यहाँ क्लिक करें"><i class="far fa-hand-point-right"></i> अग्न्याशय का कैंसर</a> <a href="https://hindi.hilarispublisher.com/scholarly/bone-marrow-cancer-survival--journals-articles-ppts-list-2274.html" class="nav-link" title="अस्थि मज्जा कैंसर से बचाव" title="यहाँ क्लिक करें"><i class="far fa-hand-point-right"></i> अस्थि मज्जा कैंसर से बचाव</a> <a href="https://hindi.hilarispublisher.com/scholarly/oseophagus-cancer-journals-articles-ppts-list-2299.html" class="nav-link" title="ओसियोफैगस कैंसर" title="यहाँ क्लिक करें"><i class="far fa-hand-point-right"></i> ओसियोफैगस कैंसर</a> <a href="https://hindi.hilarispublisher.com/scholarly/kidney-cancer-prognosis-journals-articles-ppts-list-2279.html" class="nav-link" title="किडनी कैंसर का पूर्वानुमान" title="यहाँ क्लिक करें"><i class="far fa-hand-point-right"></i> किडनी कैंसर का पूर्वानुमान</a> <a href="https://hindi.hilarispublisher.com/scholarly/cancer-therapies-journals-articles-ppts-list-2304.html" class="nav-link" title="कैंसर उपचार" title="यहाँ क्लिक करें"><i class="far fa-hand-point-right"></i> कैंसर उपचार</a> <a href="https://hindi.hilarispublisher.com/scholarly/anticancer-drug-journals-articles-ppts-list-2370.html" class="nav-link" title="कैंसर रोधी दवा" title="यहाँ क्लिक करें"><i class="far fa-hand-point-right"></i> कैंसर रोधी दवा</a> <a href="https://hindi.hilarispublisher.com/scholarly/cancer-science-journals-articles-ppts-list-2300.html" class="nav-link" title="कैंसर विज्ञान" title="यहाँ क्लिक करें"><i class="far fa-hand-point-right"></i> कैंसर विज्ञान</a> <a href="https://hindi.hilarispublisher.com/scholarly/ovarian-cancer-and-prognosis-journals-articles-ppts-list-2313.html" class="nav-link" title="डिम्बग्रंथि कैंसर और रोग का निदान" title="यहाँ क्लिक करें"><i class="far fa-hand-point-right"></i> डिम्बग्रंथि कैंसर और रोग का निदान</a> <a href="https://hindi.hilarispublisher.com/scholarly/lung-tumor-journals-articles-ppts-list-2301.html" class="nav-link" title="फेफड़े का ट्यूमर" title="यहाँ क्लिक करें"><i class="far fa-hand-point-right"></i> फेफड़े का ट्यूमर</a> <a href="https://hindi.hilarispublisher.com/scholarly/lungs-cancer-cure-journals-articles-ppts-list-2286.html" class="nav-link" title="फेफड़ों के कैंसर का इलाज" title="यहाँ क्लिक करें"><i class="far fa-hand-point-right"></i> फेफड़ों के कैंसर का इलाज</a> <a href="https://hindi.hilarispublisher.com/scholarly/brain-tumor-treatment-journals-articles-ppts-list-2293.html" class="nav-link" title="ब्रेन ट्यूमर का इलाज" title="यहाँ क्लिक करें"><i class="far fa-hand-point-right"></i> ब्रेन ट्यूमर का इलाज</a> <a href="https://hindi.hilarispublisher.com/scholarly/esophageal-cancer-journals-articles-ppts-list-2295.html" class="nav-link" title="भोजन - नली का कैंसर" title="यहाँ क्लिक करें"><i class="far fa-hand-point-right"></i> भोजन - नली का कैंसर</a> <a href="https://hindi.hilarispublisher.com/scholarly/lymph-node-cancer-journals-articles-ppts-list-2291.html" class="nav-link" title="लिम्फ नोड कैंसर" title="यहाँ क्लिक करें"><i class="far fa-hand-point-right"></i> लिम्फ नोड कैंसर</a> <a href="https://hindi.hilarispublisher.com/scholarly/advances-in-alternative-lung-cancer-treatment-journals-articles-ppts-list-2298.html" class="nav-link" title="वैकल्पिक फेफड़ों के कैंसर उपचार में प्रगति" title="यहाँ क्लिक करें"><i class="far fa-hand-point-right"></i> वैकल्पिक फेफड़ों के कैंसर उपचार में प्रगति</a> <a href="https://hindi.hilarispublisher.com/scholarly/sarccoma-cancer-journals-articles-ppts-list-2297.html" class="nav-link" title="सरकोमा कैंसर" title="यहाँ क्लिक करें"><i class="far fa-hand-point-right"></i> सरकोमा कैंसर</a> <a href="https://hindi.hilarispublisher.com/scholarly/bone-cancer-stages-journals-articles-ppts-list-2282.html" class="nav-link" title="हड्डी के कैंसर के चरण" title="यहाँ क्लिक करें"><i class="far fa-hand-point-right"></i> हड्डी के कैंसर के चरण</a> </nav> </div>  <div class="mb-3"> <h4>में अनुक्रमित</h4> <nav class="nav flex-column scrollbar a-pl-0" style="max-height:40vh;"> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> CAS स्रोत सूचकांक (CASSI)<br> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> सूचकांक कॉपरनिकस<br> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> गूगल ज्ञानी<br> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> शेरपा रोमियो<br> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> अकादमिक जर्नल डेटाबेस<br> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> जे गेट खोलो<br> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> जेनेमिक्स जर्नलसीक<br> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> शैक्षणिक कुंजी<br> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> जर्नल टीओसी<br> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> चीन राष्ट्रीय ज्ञान अवसंरचना (सीएनकेआई)<br> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> उद्धरण कारक<br> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> Scimago<br> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> उलरिच की आवधिक निर्देशिका<br> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> इलेक्ट्रॉनिक जर्नल्स लाइब्रेरी<br> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> RefSeek<br> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> हमदर्द विश्वविद्यालय<br> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> ईबीएससीओ एज़<br> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> पत्रिकाओं के लिए सार अनुक्रमण की निर्देशिका<br> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> वैज्ञानिक पत्रिकाओं की विश्व सूची<br> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> ओसीएलसी- वर्ल्डकैट<br> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> विद्वान्<br> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> एसडब्ल्यूबी ऑनलाइन कैटलॉग<br> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> जीव विज्ञान की वर्चुअल लाइब्रेरी (विफैबियो)<br> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> पबलोन्स<br> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> मियार<br> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> विश्वविद्यालय अनुदान आयोग<br> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> चिकित्सा शिक्षा और अनुसंधान के लिए जिनेवा फाउंडेशन<br> </nav> </div>  <div class=" mb-3"> <h4>सम्बंधित लिंक्स</h4> <div class="card-body p-0"> <nav class="nav flex-column font-size-4 a-py-1"> <a class="nav-item nav-link p-0" href="https://hindi.hilarispublisher.com/cancer-science-therapy/indexing.html" title="यहाँ क्लिक करें"><span><i class="far fa-hand-point-right"></i></span><span class="cu_posion">सार-संक्षेप और अनुक्रमणिका</span></a> <a class="nav-item nav-link p-0" href="https://hindi.hilarispublisher.com/cancer-science-therapy/archive.html" title="यहाँ क्लिक करें"><span><i class="far fa-hand-point-right"></i></span><span class="cu_posion">विषयसूची</span></a> </nav> </div> </div>  <div class=" mb-3"> <h4>एक्सेस जर्नल खोलें</h4> <div class="card-body p-0"> <nav class="nav flex-column font-size-4 a-py-1"> <a class="nav-item nav-link p-0" href="https://hindi.hilarispublisher.com/engineering-journals.html" title="यहाँ क्लिक करें"><span><i class="far fa-hand-point-right"></i></span><span class="cu_posion">अभियांत्रिकी</span></a> <a class="nav-item nav-link p-0" href="https://hindi.hilarispublisher.com/genetics-and-molecular-biology-journals.html" title="यहाँ क्लिक करें"><span><i class="far fa-hand-point-right"></i></span><span class="cu_posion">आनुवंशिकी एवं आण्विक जीवविज्ञान</span></a> <a class="nav-item nav-link p-0" href="https://hindi.hilarispublisher.com/immunology-and-microbiology-journals.html" title="यहाँ क्लिक करें"><span><i class="far fa-hand-point-right"></i></span><span class="cu_posion">इम्यूनोलॉजी और माइक्रोबायोलॉजी</span></a> <a class="nav-item nav-link p-0" href="https://hindi.hilarispublisher.com/pharmaceutical-sciences-journals.html" title="यहाँ क्लिक करें"><span><i class="far fa-hand-point-right"></i></span><span class="cu_posion">औषधि विज्ञान</span></a> <a class="nav-item nav-link p-0" href="https://hindi.hilarispublisher.com/medical-sciences-journals.html" title="यहाँ क्लिक करें"><span><i class="far fa-hand-point-right"></i></span><span class="cu_posion">चिकित्सीय विज्ञान</span></a> <a class="nav-item nav-link p-0" href="https://hindi.hilarispublisher.com/neuroscience-and-psychology-journals.html" title="यहाँ क्लिक करें"><span><i class="far fa-hand-point-right"></i></span><span class="cu_posion">तंत्रिका विज्ञान और मनोविज्ञान</span></a> <a class="nav-item nav-link p-0" href="https://hindi.hilarispublisher.com/clinical-sciences-journals.html" title="यहाँ क्लिक करें"><span><i class="far fa-hand-point-right"></i></span><span class="cu_posion">नैदानिक विज्ञान</span></a> <a class="nav-item nav-link p-0" href="https://hindi.hilarispublisher.com/science-and-technology-journals.html" title="यहाँ क्लिक करें"><span><i class="far fa-hand-point-right"></i></span><span class="cu_posion">विज्ञान प्रौद्योगिकी</span></a> <a class="nav-item nav-link p-0" href="https://hindi.hilarispublisher.com/business-and-management-journals.html" title="यहाँ क्लिक करें"><span><i class="far fa-hand-point-right"></i></span><span class="cu_posion">व्यवसाय प्रबंधन</span></a> </nav> </div> </div> <script src="https://ajax.googleapis.com/ajax/libs/jquery/3.4.1/jquery.min.js"></script> <script type="text/javascript"> $(window).scroll(function() { var scroll = $(window).scrollTop(); if (scroll >= 1000) { $(".Information").addClass("Informationstic").fadeIn(1000); } else{ $(".Information").removeClass("Informationstic").fadeIn(1000); } }); </script> </div> </div> </section> <footer class="container-fluid bg-grey-300 border-top-1"> <div class="row py-3"> <div class="col-sm"> <h5 class="fweight-600">श्रेणियाँ</h5> <nav class="nav row a-py-2"> <a class="nav-link col-sm-6" href="https://hindi.hilarispublisher.com/engineering-journals.html" title="अभियांत्रिकी">अभियांत्रिकी</a> <a class="nav-link col-sm-6" href="https://hindi.hilarispublisher.com/genetics-and-molecular-biology-journals.html" title="आनुवंशिकी एवं आण्विक जीवविज्ञान">आनुवंशिकी एवं आण्विक जीवविज्ञान</a> <a class="nav-link col-sm-6" href="https://hindi.hilarispublisher.com/immunology-and-microbiology-journals.html" title="इम्यूनोलॉजी और माइक्रोबायोलॉजी">इम्यूनोलॉजी और माइक्रोबायोलॉजी</a> <a class="nav-link col-sm-6" href="https://hindi.hilarispublisher.com/pharmaceutical-sciences-journals.html" title="औषधि विज्ञान">औषधि विज्ञान</a> <a class="nav-link col-sm-6" href="https://hindi.hilarispublisher.com/medical-sciences-journals.html" title="चिकित्सीय विज्ञान">चिकित्सीय विज्ञान</a> <a class="nav-link col-sm-6" href="https://hindi.hilarispublisher.com/neuroscience-and-psychology-journals.html" title="तंत्रिका विज्ञान और मनोविज्ञान">तंत्रिका विज्ञान और मनोविज्ञान</a> <a class="nav-link col-sm-6" href="https://hindi.hilarispublisher.com/clinical-sciences-journals.html" title="नैदानिक विज्ञान">नैदानिक विज्ञान</a> <a class="nav-link col-sm-6" href="https://hindi.hilarispublisher.com/science-and-technology-journals.html" title="विज्ञान प्रौद्योगिकी">विज्ञान प्रौद्योगिकी</a> <a class="nav-link col-sm-6" href="https://hindi.hilarispublisher.com/business-and-management-journals.html" title="व्यवसाय प्रबंधन">व्यवसाय प्रबंधन</a> </nav> </div> <div class="col-sm-3 border-left-1"> <h5 class="fweight-600">दिशा-निर्देश</h5> <ul class="list-unstyled mb-0 a-py-2"> <li><a href="https://hindi.hilarispublisher.com/manuscript-guidelines.html" title="यहाँ क्लिक करें">लेखक दिशानिर्देश</a></li> <li><a href="https://hindi.hilarispublisher.com/editor-guidelines.html" title="यहाँ क्लिक करें">संपादक दिशानिर्देश</a></li> <li><a href="https://hindi.hilarispublisher.com/reviewer-guidelines.html" title="यहाँ क्लिक करें">समीक्षक दिशानिर्देश</a></li> </ul> </div> <div class="col-sm-2 border-left-1"> <h5 class="fweight-600">हिलारिस के बारे में</h5> <ul class="list-unstyled mb-0 a-py-2"> <li><a href="https://hindi.hilarispublisher.com/about-us.html" title="यहाँ क्लिक करें">हमारे बारे में</a></li> <li><a href="https://hindi.hilarispublisher.com/open-access.html" title="यहाँ क्लिक करें">खुला एक्सेस</a></li> <li><a href="https://hindi.hilarispublisher.com/contact-us.html" title="यहाँ क्लिक करें">संपर्क करें</a></li> <li><a href="https://hindi.hilarispublisher.com/terms-conditions.html" title="यहाँ क्लिक करें">शर्तें</a></li> <li><a href="https://hindi.hilarispublisher.com/faq.html" title="यहाँ क्लिक करें">पूछे जाने वाले प्रश्न</a></li> </ul> </div> <div class="col-sm-2 border-left-1"> <h5 class="fweight-600">हमारे पर का पालन करें</h5> <ul class="list-unstyled mb-0 a-py-2 footer_social"> <li><a href="https://www.facebook.com/hilarispublisher/" title="यहाँ क्लिक करें" target="blank"><i class="fab fa-facebook-square"></i></a></li> <li><a href="https://twitter.com/hilarispublish2" title="यहाँ क्लिक करें" target="blank"><i class="fab fa-twitter-square"></i></a></li> <li><a href="https://www.linkedin.com/company/31133357/admin/" title="यहाँ क्लिक करें" target="blank"><i class="fab fa-linkedin"></i></a></li> <li><a href="https://www.instagram.com/hilaris_publisher/?hl=en" title="यहाँ क्लिक करें" target="blank"><i class="fa fa-instagram"></i></a></li> <li><a href="#" title="यहाँ क्लिक करें" target="blank"><i class="fab fa-youtube"></i></a></li> </ul> </div> </div>  <div class="row"> <div class="col-12"> <p class="border-top-1 pt-2 text-right">कॉपीराइट © 2024 सर्वाधिकार सुरक्षित <strong><a href="https://hindi.hilarispublisher.com/" title="Hilaris">हिलारिस एसआरएल</a></strong></p> </div> </div> </footer>  <a class="cd-top js-cd-top animate-icon" href="https://hindi.hilarispublisher.com/submit-manuscript.html" title="Scroll to Top"> <span target="_blank" class="animate-icon-vertical"> <i class="material-icons animate-icon-vertical-wrap animate-icon-bottom-to-top">arrow_upward</i> <i class="material-icons animate-icon-vertical-wrap animate-icon-bottom-to-top">arrow_upward</i> </span> </a>   <script src="https://code.jquery.com/jquery-3.3.1.min.js"></script> <script src="https://cdnjs.cloudflare.com/ajax/libs/popper.js/1.14.7/umd/popper.min.js"></script> <script src="https://stackpath.bootstrapcdn.com/bootstrap/4.3.1/js/bootstrap.min.js"></script> <script src="https://cdn.jsdelivr.net/npm/bootstrap-select@1.13.9/dist/js/bootstrap-select.min.js"></script> <script src="/assets/js/owl.carousel.min.js"></script> <script src="/assets/js/grids.min.js" type="text/javascript"></script> <script src="/assets/js/jquery.matchHeight-min.js" type="text/javascript"></script>  <script> jQuery(function($) { $(window).scroll(function fix_element() { $('#target').css( $(window).scrollTop() > 100 ? { 'position': 'fixed', 'top': '440px' } : { 'position': 'absolute', 'top': '440px' } ); return fix_element; }()); }); </script>   <script src="/assets/js/scroll-to-top.js"></script> <script type="text/javascript"> // Equal Height var EqualHeight = function() { "use strict"; // Handle Equal Height var handleEqualHeight = function() { $(function($) { var i; for (i = 0; i < 5; i++) { //alert(i); $('.equal-height-'+i).responsiveEqualHeightGrid(); } }); } return { init: function() { handleEqualHeight(); // initial setup for equal height } } }(); $(document).ready(function() { EqualHeight.init(); }); </script> <script> $(function() { $('.match-height').matchHeight({ byRow: true, property: 'height', target: null, }); }); </script> <script> $(document).ready(function() { $('.subject-carousel').owlCarousel({ margin: 20, rewind: true, dots: false, nav: true, autoplay: true, autoplayTimeout: 2000, autoplayHoverPause: true, responsive: { 0: { items: 1 }, 600: { items: 3 }, 1000: { items: 6 } } }) }); </script> <script> $('.eb-carousel').owlCarousel({ loop: true, margin: 20, dots: false, autoplay: true, autoplayTimeout: 2000, autoplayHoverPause: true, responsive: { 0: { items: 1 }, 600: { items: 3 }, 1000: { items: 4 } } }) </script> <script src="/assets/js/jquery.mCustomScrollbar.concat.min.js" type="text/javascript"></script> <script type="text/javascript"> // Scrollbar var Scrollbar = function() { "use strict"; // Handle Scrollbar Linear var handleScrollbarLinear = function() { $(".scrollbar").mCustomScrollbar({ theme: "minimal-dark" }); } return { init: function() { handleScrollbarLinear(); // initial setup for scrollbar linear } } }(); $(document).ready(function() { Scrollbar.init(); }); /*========================== Bootstrap Popover ============================*/ $(function () { $('[data-toggle="popover"]').popover() }) </script> <script src="/assets/js/jquery.malihu.PageScroll2id.min.js" type="text/javascript"></script> <script type="text/javascript">(function($){ $(window).on("load",function(){ $("a[rel='m_PageScroll2id']").mPageScroll2id(); }); })(jQuery); </script>  <script type="text/javascript" src="/assets/js/coolautosuggest.js"></script> <script language="javascript" type="text/javascript"> $("#keyword").coolautosuggest({ url: "https://hindi.hilarispublisher.com/author-names.php?chars=", minChars: 3, }); </script>  <script type="text/javascript"> $(document).ready(function() { $("#wait").hide(); $("#jkeyword").keyup(function() { $("#wait").show(); //values of sending variables var jkeyword=$("#jkeyword").val(); var dataString = { 'jkeyword':jkeyword }; $.ajax ({ type: "POST", url: "https://hindi.hilarispublisher.com/journal-search.php", data:dataString, cache: false, success: function(html) { $("#jresult").html(html); $("#wait").hide();} }); }); }); </script>  <script type="text/javascript">function add_chatinline(){var hccid=70908001;var nt=document.createElement("script");nt.async=true;nt.src="https://www.mylivechat.com/chatinline.aspx?hccid="+hccid;var ct=document.getElementsByTagName("script")[0];ct.parentNode.insertBefore(nt,ct);} add_chatinline();</script></body> </html>

CINXE.COM

कैंसर विज्ञान एवं चिकित्सा | 9 | 2017