Preclinical Formulation Development CDMO & CRO Services

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Studies" title="Formulations for PK/Efficacy/Tox Studies"> </div> <div class="banner_shadow"> <div class="shadow_container m_width flex"> <h1 class="theme second_font color_white fadeInUp wow"> Formulations for PK/Efficacy/Tox Studies </h1> </div> </div> </li> </ul> </div> <div class="sep_breadcrumb"> <div class="sep_container m_width"> <div class="div_boxs flex"> <i class="fa fa-map-marker"></i> <ul class="breadcrumb"><li><a href="/">Home</a></li><li><a href="/service-and-solutions/" title="Small Molecule">Small Molecule</a></li><li><a href="/pre-formulation/" title="Pre-formulation Studies">Pre-formulation Studies</a></li><li><a href="/preclinical-formulation-development/" title="Formulations for PK/Efficacy/Tox Studies">Formulations for PK/Efficacy/Tox Studies</a></li></ul><script 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If you do this, you will most likely lose time and money with unnecessary and confusing PK studies. This led to the development of our SMART biopharmaceutical solutions that offer input from our scientific advisory board: A one-stop shop from candidate selection through GMP FIH.</p><p><br/></p><div><p><img src="/uploads/image/20220829/preclinical-formulation.jpg" title="preclinical formulation" alt="preclinical formulation" height="400" border="0" vspace="0"/><br/></p><p><br/></p><p>This is an integrated approach to finding the right form and formulation at every step of the development cycle using decision trees and guidance documents built from our over 80 years of innovative pharmaceutical experience. Using our SMART services will lead to the shortest possible development timelines with limited resource utilization.</p><p><br/></p><p>Our formulation approaches to deliver molecules to support PK/Efficacy/Tox Studies include solution and suspension formulation selection through vehicle screening, solubilization through pH adjustment, co-solvents, surfactants, cyclodextrin, in-situ salt formation. In addition, we also apply special drug delivery technologies for insoluble compounds.</p><p><br/></p><p>　■ <strong>Conventional </strong>- <span style="text-wrap: wrap;">Solution/Suspension </span>Formulations</p><p style="text-wrap: wrap;">　　● pH Adjustment</p><p style="text-wrap: wrap;">　　● Co-solvents</p><p style="text-wrap: wrap;">　　● Surfactants</p><p style="text-wrap: wrap;">　　● Cyclodextrin</p><p style="text-wrap: wrap;">　　● <em>In-situ</em> Salt</p><p style="text-wrap: wrap;"><br/></p><p style="text-wrap: wrap;">　■ <strong>Enabling</strong> - Enhance Solubility & Bioavailability</p><p>　　● Amorphous Solid Dispersion </p><p>           - <em>Spray drying or Lyophilization</em></p><p>　　● Size Reduction</p><p>   <em>        - Nano-milling: Nano-suspension</em></p><p><em>           - Micronization by Jet-milling</em></p><p>　　● Lipid-based Formulation</p><p>　　● Self-emulsifying Drug Delivery Systems (SEDDS)</p><p><br/></p><table><tbody><tr class="firstRow"><td><p><img src="/uploads/image/20240715/1.png" title="1.png" alt="1.png" width="200" height="228" border="0" vspace="0" style="width: 200px; height: 228px;"/></p></td><td><img src="https://www.crystalpharmatech.com/uploads/image/20240715/Nano-milling.png" title="Nano-milling.png" style="text-wrap: wrap; width: 200px; height: 230px;" width="200" height="230" border="0" vspace="0" alt="Nano-milling.png"/></td><td><img src="https://www.crystalpharmatech.com/uploads/image/20240715/Spray_Drying.png" title="Spray_Drying.png" style="text-wrap: wrap; width: 200px; height: 230px;" width="200" height="230" border="0" vspace="0" alt="Spray_Drying.png"/></td><td><img src="https://www.crystalpharmatech.com/uploads/image/20240715/Freeze_Drying.png" title="Freeze_Drying.png" style="text-wrap: wrap; width: 200px; height: 233px;" width="200" height="233" border="0" vspace="0" alt="Freeze_Drying.png"/></td><td><img src="/uploads/image/20240715/2.png" title="Extruder" alt="Extruder" width="200" height="230" border="0" vspace="0" style="width: 200px; height: 230px;"/></td></tr><tr><td align="center" valign="top" style="word-break: break-all;"><strong>Micronization</strong><p>1~10 μm</p></td><td align="center" valign="top" style="word-break: break-all;"><p><strong>Nano-milling</strong></p><p><1000 nm</p></td><td align="center" valign="top" style="word-break: break-all;"><p><strong>Spray Drying</strong></p><p>ASD</p></td><td align="center" valign="top"><p><strong>Freeze Drying</strong></p><p>Lyophilization</p></td><td align="center" valign="top" style="word-break: break-all;"><p><strong>Extruder</strong></p><p>Liposome</p></td></tr></tbody></table></div> </div> <div class="service_pdf m_width fadeInUp wow"> <h2>Resources of Preclinical Formulation Development</h2> <div class="service_pdf_group flex"> <div class="service_pdf_item"> <div class="img"> <img src="/uploads/image/20240723/17/cover.webp" alt="White Paper Preclinical Formulation Development 4-30-17" title="White Paper Preclinical Formulation Development 4-30-17"> </div> <div class="text flex"> <div> <div class="type">Application Note</div> <a href="/uploads/file/white-paper-preclinical-formulation-development-4-30-17.pdf" class="title second_font">White Paper Preclinical Formulation Development 4-30-17</a> </div> <a href="/uploads/file/white-paper-preclinical-formulation-development-4-30-17.pdf" class="href iconfont"></a> </div> </div> </div> </div> <div class="img_show_title m_width fadeInUp wow" id="contact"> Achieve Your Success with Our Expertise </div> <div class="inner_content m_width">By providing your e-mail address, you agree to receive an e-mail response from Crystal Pharmatech to your inquiry. 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