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<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Strict//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-strict.dtd"> <html xml:lang="en-us" lang="en-us" xmlns="http://www.w3.org/1999/xhtml"> <head> <meta http-equiv="Content-type" content="text/html;charset=UTF-8" /> <title>Gladyshev Lab</title> <base href="https://gladyshevlab.bwh.harvard.edu/wp-content/themes/gladyshev/" /> <link rel="stylesheet" href="https://gladyshevlab.bwh.harvard.edu/wp-content/themes/gladyshev/css/blueprint/screen.css" type="text/css" media="screen, projection" ></link> <link rel="stylesheet" href="https://gladyshevlab.bwh.harvard.edu/wp-content/themes/gladyshev/css/style.css" type="text/css"></link> <link rel="stylesheet" href="https://gladyshevlab.bwh.harvard.edu/wp-content/themes/gladyshev/js/jquery.lightbox.css" type="text/css"></link> <script type="text/javascript" src="https://ajax.googleapis.com/ajax/libs/jquery/1.4.3/jquery.min.js"></script> <script type="text/javascript" src="https://gladyshevlab.bwh.harvard.edu/wp-content/themes/gladyshev/js/script.js"></script> <script type="text/javascript" src="https://gladyshevlab.bwh.harvard.edu/wp-content/themes/gladyshev/js/jquery.lightbox.js"></script> <script type="text/javascript" src="https://gladyshevlab.bwh.harvard.edu/wp-content/themes/gladyshev/js/jquery.cycle.js"></script> </head> <body class="home"> <div id="header"> <div class="container"> <div style = "text-align: center; display: block; margin-left: auto; margin-right: auto;"> <a href="https://gladyshevlab.bwh.harvard.edu"><img src="https://gladyshevlab.bwh.harvard.edu/wp-content/themes/gladyshev/img/Small_GladyshevLab.png" alt="Gladyshev Lab" width = "200" height = "86"/></a><br> </div> <div id="headr" style="font-size: 16px; line-height: 22px"> </div> </div> </div> <div id="navbar"> <div class="container" style="padding-top: 5px; padding-left : 75px"> <a href="https://gladyshevlab.bwh.harvard.edu">Home</a> <a href="https://gladyshevlab.bwh.harvard.edu/?page_id=14">Our Research</a> <a href="https://gladyshevlab.bwh.harvard.edu/?page_id=16">Team</a> <a href="https://gladyshevlab.bwh.harvard.edu/?page_id=18">Publications</a> <a href="https://gladyshevlab.bwh.harvard.edu/?page_id=10">News</a> <a href="https://gladyshevlab.bwh.harvard.edu/?page_id=12">Online Resources & Services</a> <a href="https://gladyshevlab.bwh.harvard.edu/?page_id=8">Contact</a> </div> </div> <div id="content"> <div class="container"><div style = "text-align: center; display: block; margin-left: auto; margin-right: auto;"> <img src="img/2022NRB.jpg" width = "950"> </div> <br> <h4 style = "text-align: center; font-size: 25px; padding-top: 10px"> Follow us on Twitter! <a href="https://twitter.com/gladyshev_lab"> <img src="img/Twitter_logo_2.jpg" width = "20" height = "20"> </a> </h4> <div class = "left"> <h1 style = "text-align: center; padding-top: 30px; font-size: 30px">Featured Publication</h1> <div class="pubhome"> <br> <p style= "font-size: 20px; text-align : center"> <a href = "https://www.sciencedirect.com/science/article/pii/S0092867423004762?dgcid=author" target="_blank" style = "font-size: 20px"> <strong>Distinct longevity mechanisms across and within species and their association with aging.</strong></a></p> <br><p style = "text-align: center; font-size: 18px">Tyshkovskiy A, Ma S, Shindyapina AV, Tikhonov S, Lee S, Bozaykut P, Castro JP, Seluanov A, Schork NJ, Gorbunova V, Dmitriev SE, Miller RA, Gladyshev VN, <i>Cell </i>, 2023</p> <p style = "text-align: justify; font-size: 16px">Lifespan varies within and across species, but the general principles of its control remain unclear. Here, we conducted multi-tissue RNA-seq analyses across 41 mammalian species, identifying longevity signatures and examining their relationship with transcriptomic biomarkers of aging and established lifespan-extending interventions. An integrative analysis uncovered shared longevity mechanisms within and across species, including downregulated Igf1 and upregulated mitochondrial translation genes, and unique features, such as distinct regulation of the innate immune response and cellular respiration. Signatures of long-lived species were positively correlated with age-related changes and enriched for evolutionarily ancient essential genes, involved in proteolysis and PI3K-Akt signaling. Conversely, lifespan-extending interventions counteracted aging patterns and affected younger, mutable genes enriched for energy metabolism. The identified biomarkers revealed longevity interventions, including KU0063794, which extended mouse lifespan and healthspan. Overall, this study uncovers universal and distinct strategies of lifespan regulation within and across species and provides tools for discovering longevity interventions.</p> <a class="boxlink" href="https://gladyshevlab.bwh.harvard.edu/?page_id=18">View all publications</a> </div> <br><br>Last Updated: June 5, 2023<br> </div> <div class="right"> <h1 style="padding-top: 30px; text-align: center; font-size: 30px">Featured Software</h1> <br> <div class="pubhome"> <a href="https://www.clockbase.org/"> <center><div style="background-image: url('img/clockbase-logo-white.png'); background-size: contain; background-repeat: no-repeat; width:300px; height:250px" class="featured"> </div></center></a> <br><a class="boxlink" href="https://gladyshevlab.bwh.harvard.edu/?page_id=12">View other resources</a></div> <br> <h1 style = "padding-top: 30px; text-align: center; font-size: 30px">Featured News</h1> <div class="pubhome"> <ul> <li> <span class="nothing" style= "font-size: 14px">Vadim was elected to the National Academy of Sciences in April 2021! <a href="http://www.nasonline.org/news-and-multimedia/news/2021-nas-election.html" target="_blank">Click here to learn more about this prestigious recognition.</a></span> <br> </li></ul><a class="boxlink" href="https://gladyshevlab.bwh.harvard.edu/?page_id=10">View all news</a></div> </li> </li> </div> </div> </div> </div> <div id="footer"> <div class="container"> <div style="float: left; text-align: center; padding-top: 1px; margin-left: 40px"> <br /> </div> <a href="https://hms.harvard.edu/"> <img src="https://gladyshevlab.bwh.harvard.edu/wp-content/themes/gladyshev/img/new_harvard_logo.jpg" alt="HMS" style="width:300px;height:100px;"/></a> <a href="https://www.brighamandwomens.org/"> <img src="https://gladyshevlab.bwh.harvard.edu/wp-content/themes/gladyshev/img/new_bwh-logo.png" alt="HMS" style="width:300px;height:100px;padding-right: 20px"/></a> <a href="https://www.broadinstitute.org/"> <img src="https://gladyshevlab.bwh.harvard.edu/wp-content/themes/gladyshev/img/New_Broad_Logo.png" alt="HMS" style="width:270px;height:60px; padding-bottom: 25px"/></a> </div> </div> </body> </html>