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Under the Microscope: Chimeric Antigen Receptor-Mesenchymal Stromal Cells (CAR-MSCs)

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"><meta 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" 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<div class="form-group"> </div> <div class="form-group"> </div> </div> </div> <div class="col-md-2 margin-top-small clearfix"> <span id="MainCopy_ctl03_ucPermission_IconFollow" class="pull-right"> </span> </div> <div class="col-md-2 clearfix"> <div id="MainCopy_ctl03_ucPermission_pnlRating" class="pull-right"> <div id="MainCopy_ctl03_ucPermission_BlogItemRating_CommentPanel" class="CommentPanel ItemRatingCommentPanel"> <script type="text/javascript"> function showLikesModal(itemkey) { var req = {}; req.ItemKey = itemkey; hl_common_ui_blockUI(); $.ajax({ contentType: 'application/json; charset=utf-8', type: 'POST', data: JSON.stringify(req), dataType: 'html', url: '/HigherLogic/UI/MVC/common/itemrating/GetRecommendedByModalPartial', success: function (data) { var $nom = $('#recommended-by-modal'); if ($nom.length > 0) { $nom.remove(); } $('body').append(data); $('#recommended-by-modal').modal('show'); hl_common_ui_unBlockUI(); }, }); } function showDemographicLikesModal(demographicKey, contactKey) { var req = {}; req.DemographicKey = demographicKey; req.ContactKey = contactKey; hl_common_ui_blockUI(); $.ajax({ contentType: 'application/json; charset=utf-8', type: 'POST', data: JSON.stringify(req), dataType: 'html', url: '/HigherLogic/UI/MVC/common/itemrating/GetDemographicRecommendedByModalPartial', success: function (data) { var $nom = $('#recommended-by-modal'); if ($nom.length > 0) { $nom.remove(); } $('body').append(data); $('#recommended-by-modal').modal('show'); hl_common_ui_unBlockUI(); }, }); } </script> <div id="MainCopy_ctl03_ucPermission_BlogItemRating_likeRatingContainer" class="" style="margin-top:5px;"> <a id="MainCopy_ctl03_ucPermission_BlogItemRating_hypTotalLikes" title="Nbr of recommenders" class="btn btn-sm btn-default-override btn-recommend-no" href="javascript:void(0)">0</a> <a id="MainCopy_ctl03_ucPermission_BlogItemRating_lbLike" title="Recommend this item." class="btn btn-sm btn-default-override" role="button" href="javascript:WebForm_DoPostBackWithOptions(new WebForm_PostBackOptions(&quot;ctl00$MainCopy$ctl03$ucPermission$BlogItemRating$lbLike&quot;, &quot;&quot;, true, &quot;&quot;, &quot;&quot;, false, true))">Recommend</a> </div> <!-- Recommend button --> <!-- End of Recommend Button --> <!-- tooltip element --> </div> </div> </div> </div> <div class="row margin-top-large"> <div class="col-md-12"> <p>Olivia Sirpilla<br>Saad Kenderian<br>Mayo Clinic<br>Rochester, MN</p> <p> </p><p><strong>Disclaimer/Conflict of interest statement. </strong>SK is an inventor on patents in the field of CAR immunotherapy that are licensed to Novartis, Humanigen, MustangBio, and Mettaforge. SSK receives research funding from Kite, Gilead, Juno, BMS, Novartis, Humanigen, MorphoSys, Tolero, Sunesis/Viracta, LifEngine Animal Health Laboratories Inc, and Lentigen. SSK has participated in advisory meetings with Kite/Gilead, Humanigen, Juno/BMS, Capstan Bio, and Novartis. SSK has served on the data safety and monitoring board with Humanigen and Carisma. SK has severed a consultant for Torque, Calibr, Novartis, Capstan Bio, Carisma, and Humanigen. &nbsp;OS and SK are inventors on intellectual property related to the CAR-MSC technology.&nbsp;</p> <p> </p><div class="media" style="overflow: hidden"> <div class="media" style="overflow: hidden"><img src="https://higherlogicdownload.s3.amazonaws.com/ISCT/MessageImages/272c2fd7e5d4492b9b615f0deedc1d37.png" class="img-responsive" data-mce-hlimagekey="06d3ccbd-39d9-e4dd-68ec-875014d13700" data-mce-hlselector="#MainCopy_ctl04_tmceEditor_TinyMCEContent" width="252" height="251" style="display: block; margin-left: auto; margin-right: auto"></div> <div class="media" style="overflow: hidden; text-align: center"><span style="font-size: 10pt">Mesenchymal stromal cell (actin cytoskeleton in green) expressing CAR (purple) receptor at the cell surface, where it </span></div> <div class="media" style="overflow: hidden; text-align: center"><span style="font-size: 10pt">detects </span><span style="font-size: 10pt">and </span><span style="font-size: 10pt">engages with target cells to initiate immunosuppressive response.</span></div> <div class="media" style="overflow: hidden; text-align: left"><span style="font-size: 10pt"></span></div> <div class="media" style="overflow: hidden; text-align: left"><span style="font-size: 10pt"><img src="https://higherlogicdownload.s3.amazonaws.com/ISCT/MessageImages/eadfd1beec7f4f8db4419cd2df90b1a9.png" class="img-responsive" data-mce-hlimagekey="ef1b0d75-1fac-ee18-71d6-b746875f46a1" data-mce-hlselector="#MainCopy_ctl04_tmceEditor_TinyMCEContent" width="363" height="194" style="display: block; margin-left: auto; margin-right: auto"></span></div> <div class="media" style="overflow: hidden; text-align: left"> <p class="MsoNormal" align="center" style="margin-bottom: 6pt; text-align: center; line-height: normal"><span lang="EN-US" style="font-size: 10pt">Rationale of CAR-MSC. CAR equips MSCs with enhanced trafficking through the scFv and their suppressive </span></p> <p class="MsoNormal" align="center" style="margin-bottom: 6pt; text-align: center; line-height: normal"><span lang="EN-US" style="font-size: 10pt">functions through the intracellular signaling domains.</span></p> <p class="MsoNormal" align="center" style="margin-bottom: 6pt; text-align: center; line-height: normal"><span lang="EN-US" style="font-size: 10pt"></span></p> <p><strong><span lang="EN-US">What?</span></strong><span lang="EN-US"><strong> </strong></span></p> <p><span lang="EN-US">CAR-MSCs are engineered allogeneic MSCs equipped with stable expression of chimeric antigen receptors (CARs) for functional therapeutic enhancement. To generate CAR-MSCs, MSCs are engineered with modified lentiviruses to stably express the desired CARs. CAR-MSCs and are then cryopreserved and stored until the time of their off-the-shelf infusion. CAR-MSCs are designed to equip cells to be more effective than non-engineered MSCs in treating autoimmune and degenerative diseases.</span></p> <p><span lang="EN-US"></span></p> <p><strong><span lang="EN-US">Why?</span></strong><span lang="EN-US"><strong> </strong></span></p> <p><span lang="EN-US">CAR-MSCs overcome two main limitations in current MSC therapeutics: 1) Trafficking to sites of inflammation through the incorporation of a tissue-specific antigen binding domain within the CAR, and 2) Insufficient immunosuppression through the insertion and signal transduction of an immunosuppressive CAR intracellular signaling domain. Applying a functional CAR design to MSCs offers a dynamic way to address issues of limited trafficking, heterogeneity, and inconsistent immunosuppressive efficacy in current MSC clinical trials.</span></p> <p><span lang="EN-US"></span></p> <p><strong><span lang="EN-US">Who?</span></strong><span lang="EN-US"><strong> </strong></span></p> <p><span lang="EN-US">Adoptive MSC therapy is the most widely studied form of cellular therapy without any current FDA approval. More than 1000 clinical trials for autologous or allogeneic MSC therapy have been carried out for the treatment of immune mediated diseases </span><span lang="EN-US">(1)</span><span lang="EN-US">. MSCs represent an attractive cell therapy platform due to their low immunogenicity, regenerative potential and off-the-shelf use. Engineering MSCs with CARs represents a modular novel platform that can be modified and adapted for the treatment of different immune mediated and degenerative diseases.</span></p> <p><span lang="EN-US"></span></p> <p><strong><span lang="EN-US">When?</span></strong><span lang="EN-US"><strong> </strong></span></p> <p><span lang="EN-US">While the term MSC was first coined in the early 1990s, work on the identification, source, growth kinetics, and biology started in the 19th century. MSCs were first trialed as a cellular therapy in the 1990s as well </span><span lang="EN-US">(2, 3)</span><span lang="EN-US">. However, despite their activity in preclinical models, the efficacy of MSCs in treating immune mediated diseases in patients was modest. As a result, several efforts are ongoing to improve the activity and trafficking of MSC, through the modification of culture conditions, MSC priming or engineering </span><span lang="EN-US">(4, 5)</span><span lang="EN-US">. Unlike other strategies, CAR engineering of MSCs improves multiple functions within the same product. The invention and development of CAR-MSC started in 2021. The discovery and preclinical studies were published in Nature Biomedical Engineering in April 2024 </span><span lang="EN-US">(6)</span><span lang="EN-US">. As a result of this work, a lead construct targeting E-cadherin was developed and optimized for the treatment of graft versus host disease and inflammatory bowel disease. Process development and IND enabling studies were initiated in November 2023, with a target IND submission of early 2025.</span></p> <p><span lang="EN-US"></span></p> <p><strong><span lang="EN-US">Where?</span></strong><span lang="EN-US"><strong> </strong></span></p> <p><span lang="EN-US">The cellular engineering lab of Dr. Saad Kenderian at the Mayo Clinic in Rochester, Minnesota are pioneering this technology and are the first to generate and introduce CAR-MSCs as a cell therapy product. A proof-of-concept phase I clinical trial in patients with GVHD is planned at Mayo Clinic in Rochester, MN. Following that, plans are to launch a multi-center clinical trial in collaboration with industry </span><span lang="EN-US">(2)</span><span lang="EN-US">.</span></p> <p><span lang="EN-US"></span></p> <p><strong><span lang="EN-US">Did you know that…</span><span lang="EN-US"> </span></strong></p> <p class="MsoNormal" style="margin-bottom: 6pt; text-align: justify; line-height: normal"><span lang="EN-US">MSCs are the most clinically studied cell therapy to date without any form of resultant US FDA approval. MSC efficacy in clinical trials has been inconsistent </span><span lang="EN-US">(7)</span><span lang="EN-US">. CAR-MSCs overcome many of the challenges with MSC therapy and is a cost-effective off-the-shelf platform for the treatment of immune mediated diseases.</span></p> <p class="MsoNormal" style="margin-bottom: 6pt; text-align: justify; line-height: normal"><span lang="EN-US"></span></p> <p><span lang="EN-US"><strong>References</strong></span></p> <ol> <li><span lang="EN-US">Pittenger MF, Discher DE, Peault BM, Phinney DG, Hare JM, Caplan AI. Mesenchymal stem cell&nbsp;<a name="_Hlk170210859" target="_blank"></a>perspective: cell biology to clinical progress. NPJ Regen Med. 2019;4:22.</span></li> <li><span lang="EN-US">Galipeau J, Sensebe L. Mesenchymal Stromal Cells: Clinical Challenges and Therapeutic Opportunities. Cell Stem Cell. 2018;22(6):824-33.</span></li> <li><span lang="EN-US">Lazarus HM, Haynesworth SE, Gerson SL, Rosenthal NS, Caplan AI. Ex vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells): implications for therapeutic use.&nbsp;</span><span lang="ES">Bone Marrow Transplant. 1995;16(4):557-64.</span></li> <li><span lang="ES">Hervas-Salcedo R, Fernandez-Garcia M, Hernando-Rodriguez M, Suarez-Cabrera C, Bueren JA, Yanez RM. </span><span lang="EN-US">Improved efficacy of mesenchymal stromal cells stably expressing CXCR4 and IL-10 in a xenogeneic graft versus host disease mouse model. Front Immunol. 2023;14:1062086.</span></li> <li><span lang="EN-US">Noronha NC, Mizukami A, Caliari-Oliveira C, Cominal JG, Rocha JLM, Covas DT, et al. Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies. Stem Cell Res Ther. 2019;10(1):131.</span></li> <li><span lang="EN-US">Sirpilla O, Sakemura RL, Hefazi M, Huynh TN, Can I, Girsch JH, et al. Mesenchymal stromal cells with chimaeric antigen receptors for enhanced immunosuppression. Nat Biomed Eng. 2024.</span></li> <li class="EndNoteBibliography"><span lang="EN-US">Levy O, Kuai R, Siren EMJ, Bhere D, Milton Y, Nissar N, et al. Shattering barriers toward clinically meaningful MSC therapies. 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