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src="//cdnjs.cloudflare.com/ajax/libs/wow/1.1.2/wow.min.js"></script> </head> <body class="colour--navy not-front path--timeline"> <a href="#main-content" class="visually-hidden focusable skip-link"> Skip to main content </a> <div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas> <div class="main-container"> <header class="page--timeline page"> <div class="region__header--inner region--inner"> <section id="block-bccrc-breadcrumbs" class="block block--system-breadcrumb-block block-bccrc-breadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">GSC</a> </li> <li> Timeline </li> </ol> </nav> </section> <section id="block-bccrc-page-title" class="block block--page-title-block block-bccrc-page-title"> <h1>Timeline</h1> </section> </div> </header> <section class="region region__highlight"> <div class="region__highlight--inner region--inner"> <div data-drupal-messages-fallback class="hidden"></div> </div> </section> <main role="main"> <a id="main-content" tabindex="-1"></a> <div class="layout-content"> <section class="region region__content"> <div class="region__content--inner region--inner"> <section id="block-bccrc-content" class="block block--system-main-block block-bccrc-content"> <div class="views-element-container"><div class="js-view-dom-id-768cf09806a3ed8efd2974061c73086ac4edb940855ad228fba4e9439616cde6 view view--timeline"> <div class="wrapper-list"> <div class="timeline-nav-wrapper"> <ul class="timeline-nav"> </ul> </div> <ul class="timeline-list item-list left marker-center"> <li class="timeline-item clearfix odd" id="item0"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Lichen Genome Sequenced</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2021-12-01T12:00:00Z">December 2021</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p>The genome of the <a href="https://www.bcgsc.ca/news/giants-dot-lichen">Giant’s Dot Lichen</a>—a Canadian species discovered in 2019—is sequenced as part of the <a href="https://www.cgen.ca/canseq150-overview" target="_blank">CanSeq150 project</a>.</p></div></div> </div> </li> <li class="timeline-item clearfix even" id="item1"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Molecular subgroups of PNEN</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2021-10-01T12:00:00Z">October 2021</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p>Four <a href="https://www.bcgsc.ca/news/four-new-molecular-subgroups-pancreatic-neuroendocrine-neoplasms-identified">new molecular subgroups</a> of Pancreatic Neuroendocrine Neoplasms identified through research done in <a href="https://www.bcgsc.ca/labs/gorski-lab">Dr. Sharon Gorski's lab</a>. </p></div></div> </div> </li> <li class="timeline-item clearfix odd" id="item2"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Single Cell RNA sequencing</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2021-09-01T12:00:00Z">September 2021</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p>GSC researchers developed a <a href="https://www.bcgsc.ca/news/gsc-researchers-develop-new-method-single-cell-rna-sequencing">new method of single-cell RNA sequencing</a> published in <a href="https://www.frontiersin.org/articles/10.3389/fgene.2021.665888/full" target="_blank">Frontiers in Genetics</a>.</p></div></div> </div> </li> <li class="timeline-item clearfix even" id="item3"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Quality Clinical Care</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2021-09-01T12:00:00Z">September 2021</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p>The College of Physicians and Surgeons of BC Diagnostic Accreditation Program (<strong>DAP</strong>) gave <a href="https://www.bcgsc.ca/news/dap-certification-ensures-quality-clinical-care" target="_blank">full accreditation</a> to GSC facilities.</p></div></div> </div> </li> <li class="timeline-item clearfix odd" id="item4"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Dr. Adi Stief</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2021-07-01T12:00:00Z">July 2021</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p><a href="https://www.bcgsc.ca/people/adi-steif">Dr. Adi Steif</a> joined the GSC to continue research on large-scale genetic, transcriptomic and epigenetic profiling of tissues at the single cell level using statistical machine learning approaches. </p></div></div> </div> </li> <li class="timeline-item clearfix even" id="item5"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Canadian Medical Hall of Fame</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2021-04-11T12:00:00Z">April 2021</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p><a href="https://www.bcgsc.ca/people/marco-marra">Dr. Marco Marra </a>was one of six outstanding individuals inducted into the <a href="https://www.bcgsc.ca/news/marco-marra-joins-canadas-medical-hall-fame" target="_blank">Canadian Medical Hall of Fame</a>.</p></div></div> </div> </li> <li class="timeline-item clearfix odd" id="item6"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Molecular Biology of Colorectal Cancer</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2021-02-01T12:00:00Z">February 2021</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p>Research by <a href="https://www.bcgsc.ca/labs/tai-lab">Dr. Isabella Tai's lab</a> provided insight into the <a href="https://www.bcgsc.ca/news/new-study-provides-insight-molecular-biology-colorectal-cancer">molecular biology of colorectal cancer</a>.</p></div></div> </div> </li> <li class="timeline-item clearfix even" id="item7"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">3,000,000,000,000,000 </span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2021-01-01T12:00:00Z">January 2021</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p>GSC reached a new milestone by recording <a href="https://www.bcgsc.ca/news/3000000000000000" target="_blank">3 petabases</a> of sequencing data.</p></div></div> </div> </li> <li class="timeline-item clearfix odd" id="item8"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">New GSC Faculty</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2020-11-01T12:00:00Z">November 2020</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p>The GSC welcomed <a href="https://www.bcgsc.ca/news/gsc-welcomes-laura-evgin">Dr. Laura Evgin</a>, who’s research is focused on Chimeric antigen receptor (CAR) modified T cells and oncolytic viruses, and <a href="https://www.bcgsc.ca/news/gsc-welcomes-alexander-wyatt">Dr. Alexander Wyatt</a>, who studies metastatic genitourinary cancers, including prostate and bladder cancer.</p></div></div> </div> </li> <li class="timeline-item clearfix even" id="item9"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">International Effort to Sequence Cervical Cancers in Ugandan women</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2020-08-01T12:00:00Z">August 2020</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p>Analysis of the genomic characteristics of cervical cancers in Ugandan women, led by <a href="https://www.bcgsc.ca/people/marco-marra">Dr. Marco Marra</a>, published in <a href="https://www.nature.com/articles/s41588-020-0673-7" target="_blank">Nature Genetics</a>.</p></div></div> </div> </li> <li class="timeline-item clearfix odd" id="item10"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Team Science Award</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2020-06-01T12:00:00Z">June 2020</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p>The American Association for Cancer Research presented the <a href="https://www.cancer.gov/about-nci/organization/ccg/research/structural-genomics/tcga" target="_blank">Cancer Genome Atlas</a>—which several members of the GSC have contributed to including Drs. <a href="https://www.bcgsc.ca/people/marco-marra">Marco Marra</a>, <a href="https://www.bcgsc.ca/people/steven-jones">Steven Jones</a>, and <a href="https://www.bcgsc.ca/people/gordon-robertson">Gordon Robertson</a>— with a <a href="https://www.bcgsc.ca/news/researchers-canadas-michael-smith-genome-sciences-centre-bc-cancer-recognized-team-science">team science award</a>.</p></div></div> </div> </li> <li class="timeline-item clearfix even" id="item11"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">COVID-19</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2020-04-01T12:00:00Z">April 2020</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p>GSC became one of four Canadian institutions to <a href="https://www.bcgsc.ca/news/bc-scientists-begin-genetic-sequencing-canadians-covid-19">use genome science to better understand COVID-19 infection</a>. </p></div></div> </div> </li> <li class="timeline-item clearfix odd" id="item12"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">POG 570</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2020-04-01T12:00:00Z">April 2020</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p><a href="https://www.nature.com/articles/s43018-020-0050-6" target="_blank">Nature Cancer</a> published data from the first <a href="https://www.bcgsc.ca/news/dna-sequencing-reveals-scars-cancer-treatment">570 patients</a> studied through the <a href="https://www.bcgsc.ca/personalized-oncogenomics-program">POG program</a> and featured the article on its cover.</p></div></div> </div> </li> <li class="timeline-item clearfix even" id="item13"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">The GSC turned 20</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2019-11-15T12:00:00Z">November 2019</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p>On November 15, 2019 the GSC celebrated its <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="1f1e4a62-2cf6-4e7f-8224-e230b2a6af2c" href="https://www.bcgsc.ca/news/celebrating-20-years-discovery" title="Celebrating 20 years of discovery">20th anniversary</a> with an Open House and a Scientific Symposium. </p></div></div> </div> </li> <li class="timeline-item clearfix odd" id="item14"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Marathon of Hope</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2019-07-01T12:00:00Z">July 2019</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p>GSC joined the <a href="https://www.marathonofhopecancercentres.ca/" target="_blank">Marathon of Hope Cancer Centres Network</a> with the goal of advancing precision medicine by working collaboratively and sharing data.</p> <p> </p></div></div> </div> </li> <li class="timeline-item clearfix even" id="item15"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Canada Research Chair for Computational Genomics</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2019-07-01T12:00:00Z">July 2019</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p><a href="https://bcgsc.ca/people/steven-jones">Dr. Steven. Jones</a> appointed <a href="https://www.bcgsc.ca/news/steven-jm-jones-appointed-canada-research-chair-computational-genomics" target="_blank">Canada Research Chair for Computational Genomics</a>, part of an initiative by the Government of Canada and the <a href="https://www.innovation.ca/" target="_blank">Canada Foundation for Innovation</a> to fund Canada Research Chairs at 52 institutions across Canada for research excellence.</p></div></div> </div> </li> <li class="timeline-item clearfix odd" id="item16"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Stellar Sea Lion Genome Sequenced</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2019-06-01T12:00:00Z">June 2019</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p>The <a href="https://www.bcgsc.ca/news/steller-sea-lion-genome-sequenced">stellar sea lion genome</a> sequenced as part of a GSC study led by <a href="https://bcgsc.ca/people/steven-jones">Dr. Steven Jones</a>. Results are published in <a href="https://www.mdpi.com/2073-4425/10/7/486" target="_blank">Genes</a>.</p></div></div> </div> </li> <li class="timeline-item clearfix even" id="item17"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Information Security</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2019-02-06T12:00:00Z">February 2019</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p>The GSC achieved <a href="https://www.bcgsc.ca/sites/default/files/certificates/ISO270001-official_GSC_certficiate-20211117.pdf">ISO27001</a> certification—one of the highest standards for information security management in the world. </p></div></div> </div> </li> <li class="timeline-item clearfix odd" id="item18"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Mining Genomes for Antimicrobial Peptides</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2019-02-06T12:00:00Z">February 2019</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p><a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="f492e6bc-1cf4-402c-b141-b21c9e0095e9" href="https://www.bcgsc.ca/people/inanc-birol" title="Inanc Birol">Dr. Inanc Birol</a> developed a new technique, published in <a href="https://www.nature.com/articles/s41598-018-38442-1">Scientific Reports</a>, to mine novel <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="15bf8d28-7f9c-467a-bac6-e687df9921c1" href="https://www.bcgsc.ca/news/uncovering-antibiotics-and-cancer-drugs-bullfrog-dna" title="Uncovering antibiotics and cancer drugs in bullfrog DNA">antimicrobial therapies</a> from the genomes of a variety of species, aiding in the global fight against antibiotic resistance. </p></div></div> </div> </li> <li class="timeline-item clearfix even" id="item19"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Silent Genomes Project</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2018-07-01T12:00:00Z">July 2018</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p><a href="https://bcchr.ca/silent-genomes-project" target="_blank">The Silent Genomes Project</a>, which aims to reduce health care disparities and improve diagnostic success for children with genetic diseases from Indigenous populations, was launched. In <a href="https://www.bcgsc.ca/news/voicing-silent-genomes-new-documentary-features-gsc-scientist-nadine-caron">this documentary</a>, <a href="https://www.bcgsc.ca/people/nadine-caron">Dr. Nadine Caron</a>, First Nations Health Authority Chair in Cancer and Wellness, Senior Scientist at the GSC and member of the Sagamok Anishnawbek First Nation, discussed her role in the project. </p></div></div> </div> </li> <li class="timeline-item clearfix odd" id="item20"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Grizzly Bear Genome Sequenced</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2018-06-01T12:00:00Z">June 2018</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p>The <a href="https://www.bcgsc.ca/news/grizzly-bear-genome-sequenced">grizzly bear genome</a> sequenced as part of a GSC study led by <a href="https://bcgsc.ca/people/steven-jones">Dr. Steven Jones</a>. Results are published in <a href="https://www.mdpi.com/2073-4425/9/12/598" target="_blank">Genes</a>.</p></div></div> </div> </li> <li class="timeline-item clearfix even" id="item21"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">2,000,000,000,000,000</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2018-04-01T12:00:00Z">April 2018</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p>GSC reached a new milestone by recording <a href="https://www.bcgsc.ca/news/2000000000000000">2 petabases</a> of sequencing data.</p></div></div> </div> </li> <li class="timeline-item clearfix odd" id="item22"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">CanSeq150</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2017-01-01T12:00:00Z">January 2017</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p>In recognition of Canada's 150th anniversary, the GSC joined other Canadian genome centres in <a href="http://www.cgen.ca/canseq150">CanSeq150</a>, aiming to sequence the genomes of 150 iconic Canadian species. The GSC has since sequenced the beluga whale, grizzly bear, sea otter, sea lion and several others. </p></div></div> </div> </li> <li class="timeline-item clearfix even" id="item23"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Northern Biobank</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2016-01-01T12:00:00Z">January 2016</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p><a href="https://www.bcgsc.ca/people/nadine-caron">Dr. Caron </a>received $1.25 million from <a href="https://www.genomebc.ca/projects/northern-biobank-initiative-phase-2/" target="_blank">Genome British Columbia for the Northern Biobank Initiative </a>to address a growing risk that rural and remote communities in B.C. could be excluded from significant advances made in genomic research and precision medicine. </p></div></div> </div> </li> <li class="timeline-item clearfix odd" id="item24"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">1,000,000,000,000,000 base-pairs of DNA</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2015-12-22T12:00:00Z">December 2015</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p>On December 22 2015, the GSC reached the 1 petabase milestone, generating the 1,000,000,000,000,000<sup>th</sup> base-pair of DNA sequence. </p></div></div> </div> </li> <li class="timeline-item clearfix even" id="item25"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Reference Epigenomes</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2015-02-18T12:00:00Z">February 2015</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p>The GSC, as part of the <a href="http://ihec-epigenomes.org/">International Human Epigenome Consortium</a> and under leadership of <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="1b04ae53-9a7b-4188-a022-cffc2f1ba7b7" href="https://www.bcgsc.ca/people/martin-hirst" title="Martin Hirst">Dr. Martin Hirst</a>, contributed to the analysis of over 111 reference human epigenomes published in <a href="https://www.nature.com/articles/nature14248">Nature</a>. </p></div></div> </div> </li> <li class="timeline-item clearfix odd" id="item26"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Prostate Cancer Therapeutics </span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2015-01-01T12:00:00Z">January 2015</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p><a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="e75173c9-2f3d-4d31-a230-8ced29a21f8b" href="https://www.bcgsc.ca/people/marianne-sadar" title="Marianne Sadar">Dr. Marianne Sadar</a> discovered a completely <a href="https://pubmed.ncbi.nlm.nih.gov/23722902-an-androgen-receptor-n-terminal-domain-antagonist-for-treating-prostate-cancer/">novel drug</a> to treat prostate cancer; in 2015, EPI-506 entered clinical trails for use in treatment-resistant patients.</p></div></div> </div> </li> <li class="timeline-item clearfix even" id="item27"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Investigating Triple-Negative Breast Cancer</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2014-04-10T12:00:00Z">April 2014</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p><a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="11582d30-ba32-43c4-84fe-2efbd80cb974" href="https://www.bcgsc.ca/people/sharon-gorski" title="Sharon Gorski">Dr. Sharon Gorski</a> published a study in <a href="https://clincancerres.aacrjournals.org/content/early/2014/04/10/1078-0432.CCR-13-2060">Clinical Cancer Research</a> demonstrating that autophagy inhibition improves treatment efficacy in triple-negative breast cancer. </p></div></div> </div> </li> <li class="timeline-item clearfix odd" id="item28"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">GSC Scientists Among the World's Most Infuential Minds</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2014-01-01T12:00:00Z">January 2014</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p>Since 2014, several GSC scientists have been recognized as among the <a href="https://clarivate.com/webofsciencegroup/news/global-highly-cited-researchers-2019-list-reveals-top-talent-in-the-sciences-and-social-sciences/">World's Most Influential Minds</a> by Thomson Reuters/Clarivate Analytics. <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="d8517525-346c-4273-a294-156a2656de3b" href="https://www.bcgsc.ca/news/gsc-scientists-among-most-highly-cited-world" title="GSC scientists among the most highly cited in the world">Eleven GSC scientists</a> were listed again in 2020. </p></div></div> </div> </li> <li class="timeline-item clearfix even" id="item29"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Spruce Genomics </span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2013-05-13T12:00:00Z">May 2013</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p>GSC scientists, led by <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="f492e6bc-1cf4-402c-b141-b21c9e0095e9" href="https://www.bcgsc.ca/people/inanc-birol" title="Inanc Birol">Dr. Inanc Birol</a>, published in <a href="https://academic.oup.com/bioinformatics/article/29/12/1492/291965">Bioinformatics</a> the complete sequence and assembly of the White Spruce genome which, at 20 gigabases, was the largest genome ever sequenced at the time. </p></div></div> </div> </li> <li class="timeline-item clearfix odd" id="item30"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Dr. Martin Hirst</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2012-07-01T12:00:00Z">July 2012</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p><a href="https://www.bcgsc.ca/people/martin-hirst">Dr. Martin Hirst</a> became Head of Epigenomics at the GSC, conducting research focused on understanding epigenetic dysfunction in cancer.</p></div></div> </div> </li> <li class="timeline-item clearfix even" id="item31"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Medulloblastoma Advanced Genomics International Consortium</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2012-01-01T12:00:00Z">January 2012</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p>The GSC joined the <a href="https://consortiapedia.fastercures.org/consortia/magic/">Medulloblastoma Advanced Genomics International Consortium </a>(MAGIC), which aims to use genome science to define and understand subgroups of medulloblastoma, the most common childhood brain cancer. </p></div></div> </div> </li> <li class="timeline-item clearfix odd" id="item32"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Dr. Marianne Sadar</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2012-01-01T12:00:00Z">January 2012</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p><a href="https://www.bcgsc.ca/people/marianne-sadar">Dr. Marianne Sadar</a>, who’s research focuses on the development of therapeutics for prostate cancer, became a Distinguished Scientist at the GSC. </p></div></div> </div> </li> <li class="timeline-item clearfix even" id="item33"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Cancer and Microbes</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2011-07-11T12:00:00Z">July 2011</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p><a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="30bc4dec-b903-4bf6-a338-08eaf7c4a4d3" href="https://www.bcgsc.ca/people/robert-holt" title="Robert Holt">Dr. Robert Holt</a> published the first evidence of a link between colorectal cancer and <em>Fusobacterium nucleatum</em> in <a href="https://genome.cshlp.org/content/early/2011/10/05/gr.126516.111">Genome Research</a>, highlighting the link between microbes and cancer. The study was named as one of Time Magazine's top 10 medical breakthroughs of 2011. </p></div></div> </div> </li> <li class="timeline-item clearfix odd" id="item34"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Informing Patient Care</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2010-08-09T12:00:00Z">August 2010</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p>The GSC was the first in the world to demonstrate the use of whole genome analysis to inform cancer patient treatment planning, published in <a href="https://genomebiology.biomedcentral.com/articles/10.1186/gb-2010-11-8-r82">Genome Biology</a>, ushering in a new era of personalized cancer care. </p></div></div> </div> </li> <li class="timeline-item clearfix even" id="item35"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Insights Into Lymphoma </span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2010-02-15T12:00:00Z">February 2010</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p><a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="9b00e257-bda1-4830-84ba-0ced0942c63b" href="https://www.bcgsc.ca/people/ryan-morin" title="Ryan Morin">Dr. Ryan Morin</a> published a study in <a href="https://pubmed.ncbi.nlm.nih.gov/20081860-somatic-mutations-altering-ezh2-tyr641-in-follicular-and-diffuse-large-b-cell-lymphomas-of-germinal-center-origin/">Nature Genetics</a> describing recurrent somatic mutations in <em>EZH2 </em>in follicular and diffuse large B-cell lymphomas. </p></div></div> </div> </li> <li class="timeline-item clearfix odd" id="item36"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Assembling Genomes</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2009-06-01T12:00:00Z">June 2009</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p><a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="f492e6bc-1cf4-402c-b141-b21c9e0095e9" href="https://www.bcgsc.ca/people/inanc-birol" title="Inanc Birol">Dr. Inanc Birol</a> created novel computational methods for analyzing and assembling the data produced from next generation sequencers, including the <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="c4bee265-cd3d-4577-9f92-0b468c06e960" href="https://www.bcgsc.ca/resources/software/abyss" title="ABySS">award winning</a><a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="7710ae56-d6f3-4a9b-92bb-221c93c3b841" href="https://www.bcgsc.ca/award-presented-swiss-institute-bioinformatics-abyss-software" title="Award presented by the Swiss Institute of Bioinformatics for ABySS software"> </a><a href="https://pubmed.ncbi.nlm.nih.gov/19251739-abyss-a-parallel-assembler-for-short-read-sequence-data/?from_term=abyss&from_pos=3">ABySS</a> genome assembler now used by bioinformaticians worldwide. </p></div></div> </div> </li> <li class="timeline-item clearfix even" id="item37"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Visualizing Genomics Data</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2009-02-13T12:00:00Z">February 2009</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p>GSC Staff Scientist <a href="http://mkweb.bcgsc.ca/">Martin Krzywinski</a> developed a novel way to visualize complex genomics data elegantly and efficiently using a method called <a href="http://circos.ca/">Circos</a>, published in <a href="https://genome.cshlp.org/content/early/2009/06/15/gr.092759.109.abstract">Genome Research</a> and now used by scientists worldwide. </p></div></div> </div> </li> <li class="timeline-item clearfix odd" id="item38"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Centre for Clinical Genomics </span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2009-01-01T12:00:00Z">January 2009</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p><a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="a655dc10-5005-4f12-860b-c1f30326721c" href="https://www.bcgsc.ca/people/aly-karsan" title="Aly Karsan">Dr. Aly Karsan</a> led the launch of the <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="8bc570ee-6843-45ac-9e07-f396d71eba0d" href="https://www.bcgsc.ca/programs/centre-clinical-genomics" title="Centre for Clinical Genomics">Centre for Clinical Genomics</a>, which became the first College of American Pathologists (CAP) certified lab to use next generation sequencing technologies for cancer diagnostics, drastically reducing patient wait times for genetic testing. </p></div></div> </div> </li> <li class="timeline-item clearfix even" id="item39"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Advancing Epigenetics</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2007-06-11T12:00:00Z">June 2007</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p>In one of the first applications of next generation sequencing, <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="1b04ae53-9a7b-4188-a022-cffc2f1ba7b7" href="https://www.bcgsc.ca/people/martin-hirst" title="Martin Hirst">Dr. Martin Hirst</a> developed a technique to analyze the epigenome, known as ChIP-seq, published in <a href="https://www.nature.com/articles/nmeth1068">Nature Methods</a>. The method is now commonly used by researchers worldwide. </p></div></div> </div> </li> <li class="timeline-item clearfix odd" id="item40"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">The Cancer Genome Atlas</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2006-01-01T12:00:00Z">January 2006</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p>The GSC became the only international participant in <a href="https://www.cancer.gov/about-nci/organization/ccg/research/structural-genomics/tcga">The Cancer Genome Atlas</a> (TCGA), a landmark project in cancer genomics which to date has characterized tumours from 33 different cancer types. </p></div></div> </div> </li> <li class="timeline-item clearfix even" id="item41"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Next Generation Sequencing</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2006-01-01T12:00:00Z">January 2006</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p>The GSC was one of only four genome centres in the world to receive a <a href="https://www.illumina.com/science/technology/next-generation-sequencing.html">next generation DNA sequencer</a> (Solexa, which was later bought by Illumina), a technology that revolutionized the modern field of genomics. </p></div></div> </div> </li> <li class="timeline-item clearfix odd" id="item42"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Dr. Inanc Briol</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2005-01-01T12:00:00Z">January 2005</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p><a href="https://www.bcgsc.ca/people/inanc-birol">Dr. Inanc Briol</a> joined the GSC as a staff scientist to later become Distinguished Scientist and Director of the Bioinformatics Technology Lab. </p></div></div> </div> </li> <li class="timeline-item clearfix even" id="item43"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Dr. Sharon Gorski</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2004-10-01T12:00:00Z">October 2004</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p>Distinguished Scientist <a href="https://www.bcgsc.ca/people/sharon-gorski">Dr. Sharon Gorski</a>, who's research focuses on cell death and cell survival pathways in breast and pancreatic cancer, joined the GSC as a junior scientist. </p></div></div> </div> </li> <li class="timeline-item clearfix odd" id="item44"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Dr. Gregg Morin</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2004-01-01T12:00:00Z">January 2004</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p><a href="https://www.bcgsc.ca/people/ryan-morin">Dr. Gregg Morin</a> joined GSC to establish a proteomic suite and continue his research on the genetic nature of lymphoid cancers.</p></div></div> </div> </li> <li class="timeline-item clearfix even" id="item45"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Dr. Isabella Tai</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2003-10-01T12:00:00Z">October 2003</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p><a href="https://www.bcgsc.ca/people/isabella-tai">Dr. Isabella Tai</a>, a senior MD/PhD scientist with an interest in understanding the mechanisms of chemotherapy resistance, metastasis and tumour progression in gastrointestinal cancers, joined the GSC.</p></div></div> </div> </li> <li class="timeline-item clearfix odd" id="item46"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Sequencing of SARS</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2003-05-30T12:00:00Z">May 2003</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p>Scientists at the GSC were the first in the world to <a href="https://www.bcgsc.ca/platform/cg/group/papers/SARS.pdf">sequence the SARS coronavirus</a>, providing vital information for disease control. </p></div></div> </div> </li> <li class="timeline-item clearfix even" id="item47"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">The Healthy Aging Study</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2003-03-03T12:00:00Z">March 2003</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p><a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="dd91e189-865d-474b-9f84-8a81e490516f" href="https://www.bcgsc.ca/people/angela-brooks-wilson" title="Angela Brooks-Wilson">Dr. Angela Brooks-Wilson</a> launched the <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="7a77cb0f-1a76-49d9-b992-5dcad53f0be5" href="https://www.bcgsc.ca/projects/healthy-aging-study" title="The Healthy Aging Study">Healthy Aging Study</a>, aiming to understand genes that promote long-term good health in ‘super seniors’.</p></div></div> </div> </li> <li class="timeline-item clearfix odd" id="item48"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Dr. Robert Holt</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2002-01-01T12:00:00Z">January 2002</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p><a href="https://www.bcgsc.ca/people/robert-holt">Dr. Robert Holt</a>, Distinguished Scientist and Co-Director of the<a href="https://www.bccrc.ca/programs/bc-cancer-immunotherapy-program"> BC Cancer Immunotherapy Program</a>, joined the GSC.</p></div></div> </div> </li> <li class="timeline-item clearfix even" id="item49"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Dr. Angela Brooks-Wilson</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2001-08-01T12:00:00Z">August 2001</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p><a href="https://www.bcgsc.ca/people/angela-brooks-wilson">Dr. Angela Brooks-Wilson</a> joined the GSC as a distinguished scientist investigating the genetic basis of cancer susceptibility, specifically lymphoid cancers.</p></div></div> </div> </li> <li class="timeline-item clearfix odd" id="item50"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">The Human Genome Project</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="2001-03-03T12:00:00Z">March 2001</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p>GSC researchers contributed significantly to the first working draft of the complete human genome, published in a seminal <a href="https://www.nature.com/articles/35057062">Nature</a> paper with Drs. <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="1caa35ec-7f6a-4cc1-ad36-bda78030422f" href="https://www.bcgsc.ca/people/marco-marra" title="Marco Marra">Marco Marra</a> and <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="d375cfd9-7fd3-4564-af18-ece41739d804" href="https://www.bcgsc.ca/people/steven-jones" title="Steven Jones">Steven Jones</a> listed as authors.</p></div></div> </div> </li> <li class="timeline-item clearfix even" id="item51"> <div class="timeline-item-wrapper clearfix wow zoomInLeft"> <span class="timeline-marker"></span> <div class="views-field views-field-title"><span class="field-content">Genome Sciences Centre opened its doors at BC Cancer</span></div><div class="views-field views-field-field-timeline-event-date"><div class="field-content"><time datetime="1999-11-15T12:00:00Z">November 1999</time> </div></div><div class="views-field views-field-body"><div class="field-content"><p>On November 15 1999, Canada’s Michael Smith Genome Sciences Centre <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="04f3d4e3-ed0a-4e1e-a253-a8bd4ceab4a9" href="https://www.bcgsc.ca/about-us/our-story" title="Our Story">opened its doors</a> at BC Cancer.</p> 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id="Experimental-Therapeutics"><li class="title"><button data-toggle-body="network--open" class="departments">Departments</button><h2 class="site__title"><a href="http://www.bccrc.ca/dept/et">Experimental Therapeutics</a></h2></li> <li><a href="http://www.bccrc.ca/dept/et/about-us" target="_blank">About Us</a></li> <li><a href="http://www.bccrc.ca/dept/et/people" target="_blank">People</a></li> <li><a href="http://www.bccrc.ca/dept/et/programs" target="_blank">Programs</a></li> <li><a href="http://www.bccrc.ca/dept/et/services" target="_blank">Services</a></li> <li><a href="http://www.bccrc.ca/dept/et/news" target="_blank">News & Events</a></li> <li><a href="http://www.bccrc.ca/dept/et/students-trainees" target="_blank">Students & Trainees</a></li> <li><a href="http://www.bccrc.ca/dept/et/careers" target="_blank">Careers</a></li> </ul> </li><li class="depth--1 external microsite"><a href="http://www.bccrc.ca/dept/cid" class="depth--1 external microsite">Clinical Research</a><ul 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