Antiviral activity of sertindole, raloxifene and ibutamoren against transcription and replication-competent Ebola virus-like particles

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new collection</label> </li> <li> <input type="radio" id="collections-action-panel-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="save_share" data-ga-action="collections" data-ga-label="collections_radio_existing"> <label for="collections-action-panel-existing">Add to an existing collection</label> </li> </ul> </div> <div class="controls-wrapper"> <div class="action-panel-control-wrap new-collections-controls"> <label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label> <input type="text" name="add-to-new-collection" id="collections-action-panel-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="save_share" data-ga-action="create_collection" data-ga-label="non_favorties_collection"> <div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div> </div> <div class="action-panel-control-wrap existing-collections-controls"> <label for="collections-action-panel-add-to-existing" class="action-panel-label"> Choose a collection: </label> <select id="collections-action-panel-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="save_share" data-ga-action="select_collection" data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"> </select> <div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br> <a href="#">Please try again</a> </div> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="save_share" data-ga-action="collections" data-ga-label="add"> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="collections" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="bibliography-action-panel" class="bibliography-action-panel action-panel in-progress-dots-panel" aria-hidden="true" data-bibliography-open-panel-enabled="false" data-bibliography-open-panel-url-hash="#open-bibliography-panel"> <div class="inner-wrap"> <h3 class="action-panel-heading"> Add to My Bibliography </h3> <form id="bibliography-action-panel-form" class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-add-to-bibliography-max-amount="100" data-add-to-bibliography-batch-size="10" data-bibliography-delegates-url="/list-bibliography-delegates/" data-add-to-bibliography-url="/add-to-bibliography/" data-get-article-ids-by-search-url="/get-article-ids-by-search/" data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/"> <input type="hidden" name="csrfmiddlewaretoken" value="Lhv8yDOvKylkyn9E84BZvcBAivZP9LEAhdGqLXPz2NUZMKmTkHnKhxyD2sZb5PeK"> <div class="action-panel-control-wrap bibliographies-controls"> <div class="choice-group"> <ul class="bibliographies-action-add radio-group-items"> <li> <input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/> <label for="my-bibliography">My Bibliography</label> </li> </ul> </div> </div> <div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your delegates due to an error<br> <a href="#">Please try again</a> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to bibliography' panel" ref="linksrc=close_bibliography_panel" aria-controls="bibliography-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="mybib" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true" data-saved-search-open-panel-enabled="false" data-saved-search-open-panel-url-hash="#open-saved-search-panel"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your saved search </h2> <form id="saved-search-action-panel-form" class="saved-search-action-panel-form action-panel-content action-form" data-create-saved-search-url="/create-saved-search/" data-try-search-terms-url="/try-search-term/" data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/"> <input type="hidden" name="csrfmiddlewaretoken" value="Lhv8yDOvKylkyn9E84BZvcBAivZP9LEAhdGqLXPz2NUZMKmTkHnKhxyD2sZb5PeK"> <div class="action-panel-control-wrap"> <label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk"> Name of saved search: </label> <input maxlength="200" type="text" name="saved-search-name" id="saved-search-name" class="saved-search-name" value="" required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="action-panel-control-wrap"> <label for="saved-search-term" class="action-panel-label required-field-asterisk"> Search terms: </label> <textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea> </div> <div class="test-search-term-wrap"> <a href="#" class="try-search-term">Test search terms</a> </div> <div class="choice-group action-panel-extra-margin-top"> <span class="action-panel-label" id="fieldset-label"> Would you like email updates of new search results? </span> <fieldset id="saved-search-alert" aria-describedby="fieldset-label"> <legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend> <ul class="radio-group-items"> <li> <input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked> <label for="saved-search-alert-yes" class="action-panel-label">Yes</label> </li> <li> <input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no"> <label for="saved-search-alert-no" class="action-panel-label">No</label> </li> </ul> </fieldset> </div> <div class="alert-schedule-wrap"> <div class="action-panel-control-wrap"> <label class="action-panel-label"> Email: </label> <span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span> </div> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="saved-search-frequency" class="action-panel-label"> Frequency: </label> <select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency"> <option value="monthly">Monthly</option> <option value="weekly">Weekly</option> <option value="daily">Daily</option> </select> </div> <div class="action-panel-control-wrap saved-search-monthly-additional"> <label for="saved-search-monthly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-monthly-on-day" class="no-border-panel-selector"> <option value="Sunday">The first Sunday</option> <option value="Monday">The first Monday</option> <option value="Tuesday">The first Tuesday</option> <option value="Wednesday">The first Wednesday</option> <option value="Thursday">The first Thursday</option> <option value="Friday">The first Friday</option> <option value="Saturday">The first Saturday</option> <option value="day">The first day</option> <option value="weekday">The first weekday</option> </select> </div> <div class="action-panel-control-wrap saved-search-weekly-additional"> <label for="saved-search-weekly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day"> <option value="Sunday">Sunday</option> <option value="Monday">Monday</option> <option value="Tuesday">Tuesday</option> <option value="Wednesday">Wednesday</option> <option value="Thursday">Thursday</option> <option value="Friday">Friday</option> <option value="Saturday">Saturday</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-report" class="action-panel-label"> Report format: </label> <select id="saved-search-report" class="no-border-panel-selector saved-search-report"> <option value="DocSum">Summary</option> <option value="DocSumText">Summary (text)</option> <option value="Abstract">Abstract</option> <option value="AbstractText">Abstract (text)</option> <option value="MEDLINE">PubMed</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-amount" class="action-panel-label"> Send at most: </label> <select id="saved-search-amount" class="no-border-panel-selector saved-search-amount"> <option value="1">1 item</option> <option value="5" selected>5 items</option> <option value="10">10 items</option> <option value="20">20 items</option> <option value="50">50 items</option> <option value="100">100 items</option> <option value="200">200 items</option> </select> </div> <div> <input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result"> <label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox"> Send even when there aren't any new results </label> </div> <div class="action-panel-control-wrap option-text-in-email-wrap"> <label for="saved-search-email-text" class="action-panel-label"> Optional text in email: </label> <textarea name="saved-search-email-text" id="saved-search-email-text" class="saved-search-email-text"></textarea> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Saving..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Save </button> <button class="action-panel-cancel" aria-label="Close 'Your saved search' panel" ref="linksrc=close_saved_search_panel" aria-controls="saved-search-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Create a file for external citation management software </h2> <form id="citation-manager-action-panel-form" class="action-panel-content action-form" action="/results-export-ids/" data-by-search-action="/results-export-search-data/" data-by-ids-action="/results-export-ids/" method="post" data-by-search-method="post" data-by-ids-method="post"> <input type="hidden" name="csrfmiddlewaretoken" value="Lhv8yDOvKylkyn9E84BZvcBAivZP9LEAhdGqLXPz2NUZMKmTkHnKhxyD2sZb5PeK"> <input name="results-format" type="hidden" value="pubmed"/> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Sending..." data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="save"> Create file </button> <button class="action-panel-cancel" aria-label="Close 'Send citations to citation manager' panel" ref="linksrc=close_citation_manager_panel" aria-controls="citation-manager-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your RSS Feed </h2> <form id="rss-action-panel-form" class="rss-action-panel-form action-panel-content action-form" data-create-rss-feed-url="/create-rss-feed-url/" data-search-form-term-value=""> <input type="hidden" name="csrfmiddlewaretoken" value="Lhv8yDOvKylkyn9E84BZvcBAivZP9LEAhdGqLXPz2NUZMKmTkHnKhxyD2sZb5PeK"> <div class="action-panel-control-wrap"> <label for="rss-name" class="action-panel-label required-field-asterisk"> Name of RSS Feed: </label> <input maxlength="200" placeholder="Name" type="text" name="rss-name" id="rss-name" class="rss-name" value='' required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="rss-limit-wrap"> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="rss-limit" class="action-panel-label"> Number of items displayed: </label> <select id="rss-limit" class="no-border-panel-selector rss-limit"> <option value="5">5</option> <option value="10">10</option> <option value="15" selected="selected">15</option> <option value="20">20</option> <option value="50">50</option> <option value="100">100</option> </select> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Creating..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Create RSS </button> <button class="action-panel-cancel" aria-label="Close 'Your RSS' panel" ref="linksrc=close_rss_panel" aria-controls="rss-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> <div class="action-panel-control-wrap rss-link-copy-wrap"> <label for="rss-link" class="usa-sr-only">RSS Link</label> <input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link"> <button type="button" disabled class="rss-link-copy-button disabled" data-ga-category="save_share" data-ga-action="rss" data-ga-label="copy"> Copy </button> </div> </form> </div> </div> </div> </div> <div class="article-page" id="article-page" data-article-pmid="31964466"> <aside class="page-sidebar"> <div class="inner-wrap"> <div class="full-text-links"> <div class="full-view"> <h3 class="title"> Full text links </h3> <div class="full-text-links-list"> <a class="link-item dialog-focus" href="http://www.bmbreports.org/journal/view.html?volume=53&number=3&spage=166" target="_blank" rel="noopener" ref="linksrc=fulltextorjournal_fulltext&is_pmc=False&PrId=4023&itool=Abstract-def&log$=linkouticon&uid=31964466&db=pubmed&nlmid=101465334" title="See full text options at Korean Society for Biochemistry and Molecular Biology" data-ga-category="full_text" data-ga-action="Korean Society for Biochemistry and Molecular Biology" data-ga-label="31964466" ><img src="https://cdn.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--www.ksbmb.or.kr-pds-editor-2024-04-b754c80f7d0be6e695210bc439310b8a_1712104458_2114.jpg" alt="full text provider logo"><span class="text"> Korean Society for Biochemistry and Molecular Biology </span></a><a class="link-item pmc " href="https://pmc.ncbi.nlm.nih.gov/articles/pmid/31964466/" target="_blank" rel="noopener" ref="linksrc=fulltextorjournal_fulltext&is_pmc=True&PrId=3494&itool=Abstract-def&log$=linkouticon&uid=31964466&db=pubmed&nlmid=101465334" 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data-myncbi-max-collection-name-length="100" data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/"><input type="hidden" name="csrfmiddlewaretoken" value="Lhv8yDOvKylkyn9E84BZvcBAivZP9LEAhdGqLXPz2NUZMKmTkHnKhxyD2sZb5PeK"><div class="choice-group" role="radiogroup"><ul class="radio-group-items"><li><input type="radio" id="collections-action-dialog-new" class="collections-new" name="collections" value="new" data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_radio_new"><label for="collections-action-dialog-new">Create a new collection</label></li><li><input type="radio" id="collections-action-dialog-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_radio_existing"><label for="collections-action-dialog-existing">Add to an existing collection</label></li></ul></div><div class="controls-wrapper"><div class="action-panel-control-wrap new-collections-controls"><label for="collections-action-dialog-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label><input type="text" name="add-to-new-collection" id="collections-action-dialog-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="collections_button" data-ga-action="create_collection" data-ga-label="non_favorties_collection"><div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div></div><div class="action-panel-control-wrap existing-collections-controls"><label for="collections-action-dialog-add-to-existing" class="action-panel-label"> Choose a collection: </label><select id="collections-action-dialog-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="collections_button" data-ga-action="select_collection" data-ga-label="($('.collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"></select><div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br><a href="#">Please try again</a></div></div></div><div class="action-panel-actions"><button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="collections_button" data-ga-action="click" data-ga-label="add"> Add </button><button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="collections_button" data-ga-action="click" data-ga-label="cancel"> Cancel </button></div></form></div></div></div></div><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button><div class="display-options" 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Add to Search </a></li></ul></div></div></div><span class="period">. </span><span class="cit">2020 Mar;53(3):166-171.</span> </div> <span class="citation-doi"> doi: 10.5483/BMBRep.2020.53.3.175. </span> </div> <h1 class="heading-title"> Antiviral activity of sertindole, raloxifene and ibutamoren against transcription and replication-competent Ebola virus-like particles </h1> <div class="inline-authors"> <div class="authors"> <div class="authors-list"> <span class="authors-list-item "><a class="full-name" href="/?term=Yoon+YS&cauthor_id=31964466" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Yi-Seul Yoon">Yi-Seul Yoon</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Virus Research Group, Korea Research Institute of Chemical Technology (KRICT), Daejeon 34114, Korea." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Jang+Y&cauthor_id=31964466" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Yejin Jang">Yejin Jang</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Virus Research Group, Korea Research Institute of Chemical Technology (KRICT), Daejeon 34114, Korea." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Hoenen+T&cauthor_id=31964466" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Thomas Hoenen">Thomas Hoenen</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems 17493, Germany." href="#full-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Shin+H&cauthor_id=31964466" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Heegwon Shin">Heegwon Shin</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea." href="#full-view-affiliation-3" ref="linksrc=author_aff"> 3 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Lee+Y&cauthor_id=31964466" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Younghoon Lee">Younghoon Lee</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea." href="#full-view-affiliation-3" ref="linksrc=author_aff"> 3 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kim+M&cauthor_id=31964466" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Meehyein Kim">Meehyein Kim</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Virus Research Group, Korea Research Institute of Chemical Technology (KRICT), Daejeon 34114, Korea." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup></span> </div> </div> </div> <div class="short-article-details"> Affiliations <button class="more-details" id="toggle-authors" data-alt-text="Collapse" aria-controls="expanded-authors" aria-expanded="false" data-pinger-ignore 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</ul> </div> </div> </div> <ul class="identifiers" id="full-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">31964466</strong> </span> </li> <li> <span class="identifier pmc"> <span class="id-label"> PMCID: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=PMC7118351&id_type=PMC" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7118351/" data-ga-category="full_text" data-ga-action="PMCID" > PMC7118351 </a> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.5483/BMBRep.2020.53.3.175&id_type=DOI" href="https://doi.org/10.5483/bmbrep.2020.53.3.175" data-ga-category="full_text" data-ga-action="DOI" > 10.5483/BMBRep.2020.53.3.175 </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> <div class="short-view" id="short-view-heading"> <h1 class="heading-title"> Antiviral activity of sertindole, raloxifene and ibutamoren against transcription and replication-competent Ebola virus-like particles </h1> <div class="short-citation"> <span class="authors-list"> <span class="authors-list-item "><span class="full-name">Yi-Seul Yoon</span><span class="citation-separator"> et al.</span></span> </span> <span class="citation-journal"> BMB Rep<span class="citation-separator">.</span> </span> <span class="date"> <span class="citation-year">2020 Mar</span><span class="citation-separator">.</span> </span> </div> <div class="more-article-details-section with-display-settings"> <button class="more-article-details" id="toggle-article-details" data-alt-text="Hide details" ref="linksrc=toggle_article_details" aria-controls="full-article-details" aria-expanded="false" data-fetch-url="/31964466/long-authors/" data-id-prefix=""> <span class="title">Show details</span> </button> <div 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data-ga-label="Yi-Seul Yoon">Yi-Seul Yoon</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Virus Research Group, Korea Research Institute of Chemical Technology (KRICT), Daejeon 34114, Korea." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Jang+Y&cauthor_id=31964466" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Yejin Jang">Yejin Jang</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Virus Research Group, Korea Research Institute of Chemical Technology (KRICT), Daejeon 34114, Korea." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Hoenen+T&cauthor_id=31964466" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Thomas Hoenen">Thomas Hoenen</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems 17493, Germany." href="#short-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Shin+H&cauthor_id=31964466" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Heegwon Shin">Heegwon Shin</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea." href="#short-view-affiliation-3" ref="linksrc=author_aff"> 3 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Lee+Y&cauthor_id=31964466" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Younghoon Lee">Younghoon Lee</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea." href="#short-view-affiliation-3" ref="linksrc=author_aff"> 3 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kim+M&cauthor_id=31964466" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Meehyein Kim">Meehyein Kim</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Virus Research Group, Korea Research Institute of Chemical Technology (KRICT), Daejeon 34114, Korea." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup></span> </div> </div> <div class="affiliations"> <h3 class="title"> Affiliations </h3> <ul class="item-list"> <li data-affiliation-id="short-view-affiliation-1" id="short-view-affiliation-1" ><sup class="key">1</sup> Virus Research Group, Korea Research Institute of Chemical Technology (KRICT), Daejeon 34114, Korea.</li> <li data-affiliation-id="short-view-affiliation-2" id="short-view-affiliation-2" ><sup class="key">2</sup> Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems 17493, Germany.</li> <li data-affiliation-id="short-view-affiliation-3" id="short-view-affiliation-3" ><sup class="key">3</sup> Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea.</li> </ul> </div> </div> <ul class="identifiers" id="short-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">31964466</strong> </span> </li> <li> <span class="identifier pmc"> <span class="id-label"> PMCID: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=PMC7118351&id_type=PMC" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7118351/" data-ga-category="full_text" data-ga-action="PMCID" > PMC7118351 </a> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.5483/BMBRep.2020.53.3.175&id_type=DOI" href="https://doi.org/10.5483/bmbrep.2020.53.3.175" data-ga-category="full_text" data-ga-action="DOI" > 10.5483/BMBRep.2020.53.3.175 </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> </div> </header> <div class="actions-buttons inline"><div class="inner-wrap"><button class="full-text-links-button 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class="title"> Display options </div><div class="content"><div class="format-container"><span class="option-label"> Format </span><select name="format" data-initial-value="abstract" aria-label="Display format" id="inline-actions-display-format"><option value="abstract">Abstract</option><option value="pubmed">PubMed</option><option value="pmid">PMID</option></select></div></div></div></div></div></div> <div class="abstract" id="abstract"> <h2 class="title"> Abstract </h2> <div class="abstract-content selected" id="eng-abstract"> <p> A chemical library comprising 2,354 drug-like compounds was screened using a transcription and replication-competent viruslike particle (trVLP) system implementing the whole Ebola virus (EBOV) life cycle. Dose-dependent inhibition of Ebola trVLP replication was induced by 15 hit compounds, which primarily target different types of G protein-coupled receptors (GPCRs). Based on the chemical structure, the compounds were divided into three groups, diphenylmethane derivatives, promazine derivatives and chemicals with no conserved skeletons. The third group included sertindole, raloxifene, and ibutamoren showing prominent antiviral effects in cells. They downregulated the expression of viral proteins, including the VP40 matrix protein and the envelope glycoprotein. They also reduced the amount of EBOV-derived tetracistronic minigenome RNA incorporated into progeny trVLPs in the culture supernatant. Particularly, ibutamoren, which is a known agonist of growth hormone secretagogue receptor (GHSR), showed the most promising antiviral activity with a 50% effective concentration of 0.2 μM, a 50% cytotoxic concentration of 42.4 μM, and a selectivity index of 222.8. Here, we suggest a strategy for development of anti-EBOV therapeutics by adopting GHSR agonists as hit compounds. [BMB Reports 2020; 53(3): 166-171]. </p> </div> </div> <p class="disclaimer" id="disclaimer"> <a href="/disclaimer/" target="_blank" ga_category="literature_resources" ga_action="disclaimer_link" ga_label="under_abstract">PubMed Disclaimer</a> </p> <div class="conflict-of-interest" id="conflict-of-interest"> <h2 class="title"> Conflict of interest statement </h2> <div class="statement"> <p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one"><bold>CONFLICTS OF INTEREST</bold></p> <p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">The authors have no conflicting interests.</p> </div> </div> <div class="figures" id="figures"> <h2 class="title"> Figures </h2> <div class="figures-list" id="slides-container" itemscope itemtype="http://schema.org/ImageGallery"> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="0" data-label-slug="fig-1"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f50e/7118351/e4ecb565e431/BMB-53-166-f1.jpg" itemprop="contentUrl" aria-describedby="figure-caption-0" role="button" data-image-width="794" data-image-height="573" data-image-alt="Fig. 1" data-pmc-id="PMC7118351" data-figure-id="F1"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-0" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f50e/7118351/a5a42d16b37d/BMB-53-166-f1.gif" alt="Fig. 1" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="794"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="573"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Fig. 1 </p> </strong> <div class="figure-caption-contents"><p> Screening of anti-EBOV compounds using… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Fig. 1 </p> </strong> <div class="figure-caption-contents"><p> Screening of anti-EBOV compounds using the trVLP system. (A) Flow chart showing the… </p></div> </div> <figcaption id="figure-caption-0" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Fig. 1 </strong> <div class="figure-caption-contents">Screening of anti-EBOV compounds using the trVLP system. (A) Flow chart showing the screening procedure. (B) Z’ factor plot derived from HTS performed in 96-well plates. Black spots present the results of the FLuc assay and red spots those of the RLuc assay. The signal-to-basal ratio (S/B), coefficient of variation (CV), and average Z’ factor are shown. The dashed line indicates a threshold of 0.5. (C) trVLP replication (y-axis) and cell viability (x-axis) are expressed as percentages in the presence of 2,354 different compounds (each at 10 μM). The green box highlights 86 primary hits that suppressed trVLP replication below 15% and maintained viability of HEK293T cells between 80% and 120%.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="1" data-label-slug="fig-2"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f50e/7118351/f467149009ed/BMB-53-166-f2.jpg" itemprop="contentUrl" aria-describedby="figure-caption-1" role="button" data-image-width="713" data-image-height="580" data-image-alt="Fig. 2" data-pmc-id="PMC7118351" data-figure-id="F2"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-1" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f50e/7118351/ec0afa86f4b7/BMB-53-166-f2.gif" alt="Fig. 2" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="713"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="580"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Fig. 2 </p> </strong> <div class="figure-caption-contents"><p> Antiviral activity of highly purified… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Fig. 2 </p> </strong> <div class="figure-caption-contents"><p> Antiviral activity of highly purified sertindole, raloxifene, and ibutamoren. HEK293T cells were applied… </p></div> </div> <figcaption id="figure-caption-1" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Fig. 2 </strong> <div class="figure-caption-contents">Antiviral activity of highly purified sertindole, raloxifene, and ibutamoren. HEK293T cells were applied to the trVLP system in the presence of increasing concentrations of sertindole (A), raloxifene (B) or ibutamoren (C) using RBV (D) as a control. Percentage cell viability (black circles) and percentage trVLP replication (red squares) were assessed in FLuc and RLuc assays, respectively. EC<sub>50</sub> and CC<sub>50</sub> values were calculated via non-linear regression analysis using the GraphPad Prism 6 software. The means ± standard deviations of the EC<sub>50</sub>, CC<sub>50</sub>, and SI values are shown on the corresponding panels. These data are derived from two independent experiments in triplicate.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="2" data-label-slug="fig-3"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f50e/7118351/4ad78022bf78/BMB-53-166-f3.jpg" itemprop="contentUrl" aria-describedby="figure-caption-2" role="button" data-image-width="794" data-image-height="581" data-image-alt="Fig. 3" data-pmc-id="PMC7118351" data-figure-id="F3"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-2" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f50e/7118351/8a8d01bd1153/BMB-53-166-f3.gif" alt="Fig. 3" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="794"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="581"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Fig. 3 </p> </strong> <div class="figure-caption-contents"><p> Inhibition of viral protein expression… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Fig. 3 </p> </strong> <div class="figure-caption-contents"><p> Inhibition of viral protein expression and progeny trVLP generation. (A) Western blot analysis… </p></div> </div> <figcaption id="figure-caption-2" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Fig. 3 </strong> <div class="figure-caption-contents">Inhibition of viral protein expression and progeny trVLP generation. (A) Western blot analysis to detect VP40. Cells were transfected and infected with trVLP with increasing concentrations of each compound. On day 2 p.i., immunoblot analysis was performed with antibodies specific for VP40 (upper), NP (middle), or β-actin (lower). -V, no transfection and no infection control. M, trVLP-infected, DMSO-treated mock control. (B) Confocal microscopy for detection of viral GP. HEK293T cells were transfected and infected with trVLP and then treated with DMSO (0.2% v/v), 100 μM RBV, or 10 μM of each hit compound (sertindole, raloxifene or ibutamoren). On day 1 p.i., cells were fixed and permeabilized to probe the viral GP with an anti-GP antibody and an Alexa488-conjugated secondary antibody (green). Nuclei were counterstained with DAPI (blue). Original magnification, × 400. (C) Quantitative RT-PCR for measurement of trVLP RNA levels in the culture supernatants. HEK293T cells transfected with the plasmids mentioned above and infected with trVLP were treated with increasing concentrations of T-705, sertindole, raloxifene, or ibutamoren. On day 2 p.i., the trVLP RNA was purified from the supernatants and subjected to real-time RT-PCR with EBOV GP-specific primer sets. The experiment was performed in triplicate. Statistical significance was estimated using the DMSO-treated sample as a control. n.d., not detected. **P < 0.01; ***P < 0.001.</div> </figcaption> </figure> </div>  <div class="pswp figures-dialog" id="figures-dialog" tabindex="-1" role="dialog" aria-hidden="true" data-image-gallery-uid="article-figures" aria-label="Figures Dialog">  <div class="pswp__bg"></div>  <div class="pswp__scroll-wrap">  <div class="pswp__container"> <div class="pswp__item"></div> <div class="pswp__item"></div> <div class="pswp__item"></div> </div>  <div class="pswp__ui pswp__ui--hidden"> <div class="pswp__top-bar">  <div class="pswp__counter"></div> <button class="pswp__button pswp__button--close" title="Close (Esc)"></button> <button class="pswp__button pswp__button--share" title="Share"></button> <button class="pswp__button pswp__button--fs" title="Toggle fullscreen"></button> <button class="pswp__button pswp__button--zoom" title="Zoom in/out"></button>   <div class="pswp__preloader"> <div class="pswp__preloader__icn"> <div class="pswp__preloader__cut"> <div class="pswp__preloader__donut"></div> </div> </div> </div> </div> <div class="pswp__share-modal pswp__share-modal--hidden pswp__single-tap"> <div class="pswp__share-tooltip"></div> </div> <button class="pswp__button pswp__button--arrow--left" title="Previous (arrow left)"> </button> <button class="pswp__button pswp__button--arrow--right" title="Next (arrow right)"> </button> <div class="pswp__caption"> <div class="pswp__caption__center"></div> </div> </div> </div> </div> <div class="figure-dialog-caption"> <div class="figure-caption-link-container"> <a class="figure-caption-link" href="#">See this image and copyright information in PMC</a> </div> <div class="figure-caption-center" data-expand-title="click to show full caption" data-collapse-title="click to hide full caption"> </div> <button class="figure-caption-toggle-btn" aria-label="show full caption" data-expand-text="show full caption" data-collapse-text="hide full caption">  </button> </div> </div> <div class="similar-articles" id="similar"> <h2 class="title"> Similar articles </h2> <ul class="articles-list" id="similar-articles-list"> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"> <a class="docsum-title" href="/28807685/" ref="article_id=28807685&linksrc=similar_articles_link&ordinalpos=1" data-ga-category="similar_article" data-ga-action="28807685" data-ga-label=""> An RNA polymerase II-driven Ebola virus minigenome system as an advanced tool for antiviral drug screening. </a> <div class="docsum-citation full-citation"> <span class="docsum-authors full-authors">Nelson EV, Pacheco JR, Hume AJ, Cressey TN, Deflubé LR, Ruedas JB, Connor JH, Ebihara H, Mühlberger E.</span> <span class="docsum-authors short-authors">Nelson EV, et al.</span> <span class="docsum-journal-citation full-journal-citation">Antiviral Res. 2017 Oct;146:21-27. doi: 10.1016/j.antiviral.2017.08.005. 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J Virol. 2009;83:8993–8997. doi: 10.1128/JVI.00523-09. - <a class="reference-link" href="https://doi.org/10.1128/jvi.00523-09" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="10.1128/JVI.00523-09" > DOI </a> - <a class="reference-link" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC2738155/" ref="linksrc=references_link&ordinalpos=2" data-ga-category="reference" data-ga-action="PMC2738155" > PMC </a> - <a class="reference-link" href="/19515768/" ref="linksrc=references_link&ordinalpos=3" data-ga-category="reference" data-ga-action="19515768" > PubMed </a> </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> McCarthy SE, Johnson RF, Zhang YA, Sunyer JO, Harty RN. Role for amino acids 212KLR214 of Ebola virus VP40 in assembly and budding. J Virol. 2007;81:11452–11460. doi: 10.1128/JVI.00853-07. - <a class="reference-link" href="https://doi.org/10.1128/jvi.00853-07" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="10.1128/JVI.00853-07" > DOI </a> - <a class="reference-link" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC2045517/" ref="linksrc=references_link&ordinalpos=2" data-ga-category="reference" data-ga-action="PMC2045517" > PMC </a> - <a class="reference-link" href="/17699576/" ref="linksrc=references_link&ordinalpos=3" data-ga-category="reference" data-ga-action="17699576" > PubMed </a> </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Biedenkopf N, Schlereth J, Grunweller A, Becker S, Hartmann RK. RNA Binding of Ebola Virus VP30 Is Essential for Activating Viral Transcription. J Virol. 2016;90:7481–7496. doi: 10.1128/JVI.00271-16. - <a class="reference-link" href="https://doi.org/10.1128/jvi.00271-16" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="10.1128/JVI.00271-16" > DOI </a> - <a class="reference-link" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4984652/" ref="linksrc=references_link&ordinalpos=2" data-ga-category="reference" data-ga-action="PMC4984652" > PMC </a> - <a class="reference-link" href="/27279615/" ref="linksrc=references_link&ordinalpos=3" data-ga-category="reference" data-ga-action="27279615" > PubMed </a> </li> </ol> </li> </ol> <div class="actions-bar"> <button class="show-all" ref="linksrc=show_all_references_link" aria-controls="top-references-list-1" data-next-page-url="/31964466/references/" data-ga-category="reference" data-ga-action="show_more" > Show all 30 references </button> </div> </div> </div> </div> <div id="mesh-terms" class="mesh-terms keywords-section"> <h2 class="title"> MeSH terms </h2> <ul class="keywords-list"><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Antiviral Agents / pharmacology" tabindex="0" aria-controls="keyword-actions-mesh-terms-0" aria-expanded="false" data-pinger-ignore> Antiviral Agents / pharmacology </button><div id="keyword-actions-mesh-terms-0" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Antiviral Agents / pharmacology"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Antiviral+Agents%2Fpharmacology%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Antiviral+Agents%2Fpharmacology%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Antiviral Agents/pharmacology"[MeSH]" data-ga-category="search" 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Antiviral activity of sertindole, raloxifene and ibutamoren against transcription and replication-competent Ebola virus-like particles - PubMed