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class="vector-toc-numb">2</span> <span>PNaS family</span> </div> </a> <button aria-controls="toc-PNaS_family-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle PNaS family subsection</span> </button> <ul id="toc-PNaS_family-sublist" class="vector-toc-list"> <li id="toc-Transport_reaction" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Transport_reaction"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.1</span> <span>Transport reaction</span> </div> </a> <ul id="toc-Transport_reaction-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Human_PNaS_proteins" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Human_PNaS_proteins"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Human PNaS proteins</span> </div> </a> <ul id="toc-Human_PNaS_proteins-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-PNaS_Proteins_in_Other_Groups" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#PNaS_Proteins_in_Other_Groups"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>PNaS Proteins in Other Groups</span> </div> </a> <button aria-controls="toc-PNaS_Proteins_in_Other_Groups-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle PNaS Proteins in Other Groups subsection</span> </button> <ul id="toc-PNaS_Proteins_in_Other_Groups-sublist" class="vector-toc-list"> <li id="toc-Teleost_Fish" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Teleost_Fish"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.1</span> <span>Teleost Fish</span> </div> </a> <ul id="toc-Teleost_Fish-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Antibody" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Antibody"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Antibody</span> </div> </a> <ul id="toc-Antibody-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-See_also" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#See_also"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>See also</span> </div> </a> <ul id="toc-See_also-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" 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class="cdx-message__content"><div id="mw-revision-info-current"><p><b>This is the <a href="/wiki/Help:Page_history" title="Help:Page history">current revision</a> of this page, as edited by <span id="mw-revision-name"><a href="/w/index.php?title=User:KatieEdits&action=edit&redlink=1" class="new mw-userlink" title="User:KatieEdits (page does not exist)" data-mw-revid="1211944383"><bdi>KatieEdits</bdi></a> <span class="mw-usertoollinks">(<a href="/w/index.php?title=User_talk:KatieEdits&action=edit&redlink=1" class="new mw-usertoollinks-talk" title="User talk:KatieEdits (page does not exist)">talk</a> | <a href="/wiki/Special:Contributions/KatieEdits" class="mw-usertoollinks-contribs" title="Special:Contributions/KatieEdits">contribs</a>)</span></span> at <span id="mw-revision-date">10:55, 5 March 2024</span><span id="mw-revision-summary"> <span class="comment">(Added a bit about the genes for PNaS in teleosts. Whole page could use some reorganising, may come back and do that later.)</span></span>. The present address (URL) is a <a href="/wiki/Help:Permanent_link" title="Help:Permanent link">permanent link</a> to this version.</b></p><div id="revision-info-current-plain" style="display: none;">Revision as of 10:55, 5 March 2024 by <a href="/w/index.php?title=User:KatieEdits&action=edit&redlink=1" class="new mw-userlink" title="User:KatieEdits (page does not exist)" data-mw-revid="1211944383"><bdi>KatieEdits</bdi></a> <span class="mw-usertoollinks">(<a href="/w/index.php?title=User_talk:KatieEdits&action=edit&redlink=1" class="new mw-usertoollinks-talk" title="User talk:KatieEdits (page does not exist)">talk</a> | <a href="/wiki/Special:Contributions/KatieEdits" class="mw-usertoollinks-contribs" title="Special:Contributions/KatieEdits">contribs</a>)</span> <span class="comment">(Added a bit about the genes for PNaS in teleosts. Whole page could use some reorganising, may come back and do that later.)</span></div></div><div id="mw-revision-nav">(<a href="/w/index.php?title=Sodium/phosphate_cotransporter&diff=prev&oldid=1211944383" title="Sodium/phosphate cotransporter">diff</a>) <a href="/w/index.php?title=Sodium/phosphate_cotransporter&direction=prev&oldid=1211944383" title="Sodium/phosphate cotransporter">← Previous revision</a> | Latest revision (diff) | Newer revision → (diff)</div></div></div></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><p>The <b>sodium/phosphate cotransporter</b> is a member of the <b>phosphate:Na<sup>+</sup> symporter (PNaS) family</b> within the <a href="/wiki/TOG_Superfamily" class="mw-redirect" title="TOG Superfamily">TOG Superfamily</a> of transport proteins as specified in the <a href="/wiki/Transporter_Classification_Database" title="Transporter Classification Database">Transporter Classification Database</a> (TCDB). </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Nomenclature">Nomenclature</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sodium/phosphate_cotransporter&action=edit&section=1" title="Edit section: Nomenclature"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Sodium/phosphate cotransporters are also known as: </p> <ul><li>Na<sup>+</sup>-P<sub>i</sub> cotransport proteins (NaPi-2a)</li> <li>Sodium-dependent phosphate transporters</li> <li>Sodium-dependent phosphate symporters</li> <li>Phosphate:Na<sup>+</sup> symporters</li></ul> <div class="mw-heading mw-heading2"><h2 id="PNaS_family">PNaS family</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sodium/phosphate_cotransporter&action=edit&section=2" title="Edit section: PNaS family"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The Phosphate:Na<sup>+</sup> Symporter (PNaS) family (TC# <i><a rel="nofollow" class="external text" href="http://www.tcdb.org/search/result.php?tc=2.A.58">2.A.58</a></i>) includes several closely related, functionally characterized, sodium-dependent, inorganic phosphate (Pi) transporter (NPT) proteins from mammals. Other organisms that possess PNaS family members include many in eukaryotic, bacterial and archaeal phyla. Bacterial sodium:phosphate symporters, NptA of <i>Vibrio cholerae</i> (<a rel="nofollow" class="external text" href="http://www.tcdb.org/search/result.php?tc=2.A.58.1.2">TC#2.A.58.1.2</a>) and YjbB of <i>E. coli</i> (<a rel="nofollow" class="external text" href="http://www.tcdb.org/search/result.php?tc=2.A.58.2.1">TC# 2.A.58.2.1</a>) have been functionally characterized.<sup id="cite_ref-Lebens_1-0" class="reference"><a href="#cite_note-Lebens-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Motomura_2-0" class="reference"><a href="#cite_note-Motomura-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> </p><p>The well-characterized mammalian proteins are found in renal (IIa isoform) and intestinal (IIb isoform) brush border membranes and are about 640 amino acyl residues long with 8-12 putative TMSs. The N- and C-termini both reside in the cytoplasm, and a large hydrophilic loop is localized between trans-membrane segments (TMSs) 3 and 4. While IIa isoforms are pH-dependent, IIb isoforms are pH-independent.<sup id="cite_ref-de_la_Horra_3-0" class="reference"><a href="#cite_note-de_la_Horra-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> The IIa sodium phosphate symporter isoform is a functional monomer,<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> but it interacts with PDZ proteins which probably mediate apical sorting, parathyroid hormone-controlled endocytosis and/or lysosomal sorting of internalized transporters.<sup id="cite_ref-TCDB_5-0" class="reference"><a href="#cite_note-TCDB-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Transport_reaction">Transport reaction</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sodium/phosphate_cotransporter&action=edit&section=3" title="Edit section: Transport reaction"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The transport reaction catalyzed by the mammalian proteins is:<sup id="cite_ref-TCDB_5-1" class="reference"><a href="#cite_note-TCDB-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p> <dl><dd>P<sub>i</sub> (out) + 3 Na<sup>+</sup> (out) ⇌ P<sub>i</sub> (in) + 3 Na<sup>+</sup> (in).</dd></dl> <div class="mw-heading mw-heading2"><h2 id="Human_PNaS_proteins">Human PNaS proteins</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sodium/phosphate_cotransporter&action=edit&section=4" title="Edit section: Human PNaS proteins"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>There are several known sodium-dependent phosphate transporters found in humans. For example, the <a href="/wiki/SLC34A1" class="mw-redirect" title="SLC34A1">protein 2A</a> is encoded by the solute carrier family 34, member 1 (<i>SLC34A1</i>) <a href="/wiki/Gene" title="Gene">gene</a><sup id="cite_ref-entrez_7-0" class="reference"><a href="#cite_note-entrez-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> and facilitates uptake of phosphate for normal cellular functions including cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. The PNaS family is also called the SLC34 family. </p><p>Other known sodium-dependent phosphate transporters found in humans include (but are not limited to): </p> <ul><li>Sodium-Phosphate Cotransporter Proteins, Type I (<a rel="nofollow" class="external text" href="http://www.tcdb.org/search/result.php?tc=2.A.1.14#2.A.1.14">TC# 2.A.1.14</a>): <ul><li><a href="/wiki/SLC17A1" class="mw-redirect" title="SLC17A1">SLC17A1</a> (NPT1)</li> <li><a href="/w/index.php?title=SLC17A2&action=edit&redlink=1" class="new" title="SLC17A2 (page does not exist)">SLC17A2</a> (NPT3)</li> <li><a href="/wiki/SLC17A3" title="SLC17A3">SLC17A3</a> (NPT4)</li> <li><a href="/w/index.php?title=SLC17A4&action=edit&redlink=1" class="new" title="SLC17A4 (page does not exist)">SLC17A4</a></li></ul></li> <li>Sodium-Phosphate Cotransporter Proteins, Type II (<a rel="nofollow" class="external text" href="http://www.tcdb.org/search/result.php?tc=2.A.58">TC# 2.A.58</a>): <ul><li><a href="/wiki/SLC34A1" class="mw-redirect" title="SLC34A1">SLC34A1</a> (NPTIIa)</li> <li><a href="/wiki/SLC34A2" class="mw-redirect" title="SLC34A2">SLC34A2</a> (NPTIIb), codes for sodium-dependent phosphate transport protein 2b (<a href="/wiki/NaPi2b" class="mw-redirect" title="NaPi2b">NaPi2b</a>), a <a href="/wiki/Tumor-associated_antigen" class="mw-redirect" title="Tumor-associated antigen">tumor-associated antigen</a>.<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/SLC34A3" class="mw-redirect" title="SLC34A3">SLC34A3</a> (NPTIIc)</li></ul></li> <li>Sodium-Phosphate Cotransporter Proteins, Type III (<a rel="nofollow" class="external text" href="http://www.tcdb.org/search/result.php?tc=2.a.20">TC# 2.A.20</a>): <ul><li><a href="/wiki/SLC20A1" title="SLC20A1">SLC20A1</a> (PIT1)</li> <li><a href="/wiki/SLC20A2" title="SLC20A2">SLC20A2</a> (PIT2)</li></ul></li></ul> <div class="mw-heading mw-heading2"><h2 id="PNaS_Proteins_in_Other_Groups">PNaS Proteins in Other Groups</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sodium/phosphate_cotransporter&action=edit&section=5" title="Edit section: PNaS Proteins in Other Groups"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Teleost_Fish">Teleost Fish</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sodium/phosphate_cotransporter&action=edit&section=6" title="Edit section: Teleost Fish"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Due to the Actinopterygian whole genome duplication event, <i>slc34a1</i> and <i>slc34a2</i> are present in a duplicated form in many teleost fish - <i>slc34a1a</i> and <i>slc34a1b</i>, <i>slc34a2a</i> and <i>slc34a2b.</i><sup id="cite_ref-:0_9-0" class="reference"><a href="#cite_note-:0-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> This is not uniform and <i>slc341b</i> is frequently lost in some Actinopterygian lineages.<sup id="cite_ref-:0_9-1" class="reference"><a href="#cite_note-:0-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> <i>slc34a3</i>-type genes are not present<i>.</i><sup id="cite_ref-:0_9-2" class="reference"><a href="#cite_note-:0-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Antibody">Antibody</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sodium/phosphate_cotransporter&action=edit&section=7" title="Edit section: Antibody"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/Lifastuzumab_vedotin" title="Lifastuzumab vedotin">Lifastuzumab vedotin</a> is a <a href="/wiki/Monoclonal_antibody" title="Monoclonal antibody">monoclonal antibody</a> for the sodium/phosphate cotransporter that is under development for the treatment of <a href="/wiki/Cancer" title="Cancer">cancer</a>. </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sodium/phosphate_cotransporter&action=edit&section=8" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1184024115">.mw-parser-output .div-col{margin-top:0.3em;column-width:30em}.mw-parser-output .div-col-small{font-size:90%}.mw-parser-output .div-col-rules{column-rule:1px solid #aaa}.mw-parser-output .div-col dl,.mw-parser-output .div-col ol,.mw-parser-output .div-col ul{margin-top:0}.mw-parser-output .div-col li,.mw-parser-output .div-col dd{page-break-inside:avoid;break-inside:avoid-column}</style><div class="div-col" style="column-width: 20em;"> <ul><li><a href="/wiki/Cotransporter" title="Cotransporter">Cotransporter</a></li> <li><a href="/wiki/Co-transport" class="mw-redirect" title="Co-transport">Co-transport</a></li> <li><a href="/wiki/P-loop" class="mw-redirect" title="P-loop">P-loop</a></li> <li><a href="/wiki/Renal_physiology" title="Renal physiology">Renal physiology</a></li> <li><a href="/wiki/Symport" class="mw-redirect" title="Symport">Symport</a></li> <li><a href="/wiki/Symporter" title="Symporter">Symporter</a></li> <li><a href="/wiki/Solute_carrier_family" title="Solute carrier family">Solute carrier family</a></li> <li><a href="/wiki/Transporter_Classification_Database" title="Transporter Classification Database">Transporter Classification Database</a></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sodium/phosphate_cotransporter&action=edit&section=9" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width" style="column-width: 33em;"> <ol class="references"> <li id="cite_note-Lebens-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-Lebens_1-0">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration 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Traebert M, Bacic D, Biber J, Murer H (Mar 2001). <a rel="nofollow" class="external text" href="http://www.zora.uzh.ch/1309/2/Gisler_2001V.pdf">"Interaction of the type IIa Na/Pi cotransporter with PDZ proteins"</a> <span class="cs1-format">(PDF)</span>. <i>The Journal of Biological Chemistry</i>. <b>276</b> (12): 9206–13. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M008745200">10.1074/jbc.M008745200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11099500">11099500</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Interaction+of+the+type+IIa+Na%2FPi+cotransporter+with+PDZ+proteins&rft.volume=276&rft.issue=12&rft.pages=9206-13&rft.date=2001-03&rft_id=info%3Adoi%2F10.1074%2Fjbc.M008745200&rft_id=info%3Apmid%2F11099500&rft.aulast=Gisler&rft.aufirst=SM&rft.au=Stagljar%2C+I&rft.au=Traebert%2C+M&rft.au=Bacic%2C+D&rft.au=Biber%2C+J&rft.au=Murer%2C+H&rft_id=http%3A%2F%2Fwww.zora.uzh.ch%2F1309%2F2%2FGisler_2001V.pdf&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASodium%2Fphosphate+cotransporter" class="Z3988"></span></span> </li> <li id="cite_note-entrez-7"><span class="mw-cite-backlink"><b><a href="#cite_ref-entrez_7-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=6569">"Entrez Gene: Solute carrier family 34 (sodium phosphate), member 1"</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Entrez+Gene%3A+Solute+carrier+family+34+%28sodium+phosphate%29%2C+member+1&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3Dretrieve%26list_uids%3D6569&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASodium%2Fphosphate+cotransporter" class="Z3988"></span></span> </li> <li id="cite_note-8"><span class="mw-cite-backlink"><b><a href="#cite_ref-8">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFYinKiyamovaChuaCaballero2008" class="citation journal cs1">Yin BW, Kiyamova R, Chua R, Caballero OL, Gout I, Gryshkova V, Bhaskaran N, Souchelnytskyi S, Hellman U, Filonenko V, Jungbluth AA, Odunsi K, Lloyd KO, Old LJ, Ritter G (2008). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935786">"Monoclonal antibody MX35 detects the membrane transporter NaPi2b (SLC34A2) in human carcinomas"</a>. <i>Cancer Immun</i>. <b>8</b>: 3. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935786">2935786</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18251464">18251464</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cancer+Immun&rft.atitle=Monoclonal+antibody+MX35+detects+the+membrane+transporter+NaPi2b+%28SLC34A2%29+in+human+carcinomas&rft.volume=8&rft.pages=3&rft.date=2008&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2935786%23id-name%3DPMC&rft_id=info%3Apmid%2F18251464&rft.aulast=Yin&rft.aufirst=BW&rft.au=Kiyamova%2C+R&rft.au=Chua%2C+R&rft.au=Caballero%2C+OL&rft.au=Gout%2C+I&rft.au=Gryshkova%2C+V&rft.au=Bhaskaran%2C+N&rft.au=Souchelnytskyi%2C+S&rft.au=Hellman%2C+U&rft.au=Filonenko%2C+V&rft.au=Jungbluth%2C+AA&rft.au=Odunsi%2C+K&rft.au=Lloyd%2C+KO&rft.au=Old%2C+LJ&rft.au=Ritter%2C+G&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2935786&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASodium%2Fphosphate+cotransporter" class="Z3988"></span></span> </li> <li id="cite_note-:0-9"><span class="mw-cite-backlink">^ <a href="#cite_ref-:0_9-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:0_9-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-:0_9-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFVerriWerner2019" class="citation journal cs1">Verri, Tiziano; Werner, Andreas (2019). <a rel="nofollow" class="external text" href="http://link.springer.com/10.1007/s00424-018-2239-4">"Type II Na+-phosphate Cotransporters and Phosphate Balance in Teleost Fish"</a>. <i>Pflügers Archiv - European Journal of Physiology</i>. <b>471</b> (1): 193–212. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs00424-018-2239-4">10.1007/s00424-018-2239-4</a>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/0031-6768">0031-6768</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Pfl%C3%BCgers+Archiv+-+European+Journal+of+Physiology&rft.atitle=Type+II+Na%2B-phosphate+Cotransporters+and+Phosphate+Balance+in+Teleost+Fish&rft.volume=471&rft.issue=1&rft.pages=193-212&rft.date=2019&rft_id=info%3Adoi%2F10.1007%2Fs00424-018-2239-4&rft.issn=0031-6768&rft.aulast=Verri&rft.aufirst=Tiziano&rft.au=Werner%2C+Andreas&rft_id=http%3A%2F%2Flink.springer.com%2F10.1007%2Fs00424-018-2239-4&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASodium%2Fphosphate+cotransporter" class="Z3988"></span></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sodium/phosphate_cotransporter&action=edit&section=10" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 33em"> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFTenenhouse1999" class="citation journal cs1">Tenenhouse HS (Feb 1999). "X-linked hypophosphataemia: a homologous disorder in humans and mice". <i>Nephrology, Dialysis, Transplantation</i>. <b>14</b> (2): 333–41. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fndt%2F14.2.333">10.1093/ndt/14.2.333</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10069185">10069185</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nephrology%2C+Dialysis%2C+Transplantation&rft.atitle=X-linked+hypophosphataemia%3A+a+homologous+disorder+in+humans+and+mice&rft.volume=14&rft.issue=2&rft.pages=333-41&rft.date=1999-02&rft_id=info%3Adoi%2F10.1093%2Fndt%2F14.2.333&rft_id=info%3Apmid%2F10069185&rft.aulast=Tenenhouse&rft.aufirst=HS&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASodium%2Fphosphate+cotransporter" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMurerHernandoForsterBiber2000" class="citation journal cs1">Murer H, Hernando N, Forster I, Biber J (Oct 2000). <a rel="nofollow" class="external text" href="https://web.archive.org/web/20190303175006/http://pdfs.semanticscholar.org/b975/8bdc83a323bfe87f34a173ce18ce27539849.pdf">"Proximal tubular phosphate reabsorption: molecular mechanisms"</a> <span class="cs1-format">(PDF)</span>. <i>Physiological Reviews</i>. <b>80</b> (4): 1373–409. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1152%2Fphysrev.2000.80.4.1373">10.1152/physrev.2000.80.4.1373</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11015617">11015617</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:25310369">25310369</a>. Archived from <a rel="nofollow" class="external text" href="http://pdfs.semanticscholar.org/b975/8bdc83a323bfe87f34a173ce18ce27539849.pdf">the original</a> <span class="cs1-format">(PDF)</span> on 2019-03-03.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Physiological+Reviews&rft.atitle=Proximal+tubular+phosphate+reabsorption%3A+molecular+mechanisms&rft.volume=80&rft.issue=4&rft.pages=1373-409&rft.date=2000-10&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A25310369%23id-name%3DS2CID&rft_id=info%3Apmid%2F11015617&rft_id=info%3Adoi%2F10.1152%2Fphysrev.2000.80.4.1373&rft.aulast=Murer&rft.aufirst=H&rft.au=Hernando%2C+N&rft.au=Forster%2C+I&rft.au=Biber%2C+J&rft_id=http%3A%2F%2Fpdfs.semanticscholar.org%2Fb975%2F8bdc83a323bfe87f34a173ce18ce27539849.pdf&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASodium%2Fphosphate+cotransporter" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFFenollar-FerrerForsterPattiKnoepfel2015" class="citation journal cs1">Fenollar-Ferrer C, Forster IC, Patti M, Knoepfel T, Werner A, Forrest LR (May 2015). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457043">"Identification of the first sodium binding site of the phosphate cotransporter NaPi-IIa (SLC34A1)"</a>. <i>Biophysical Journal</i>. <b>108</b> (10): 2465–80. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.bpj.2015.03.054">10.1016/j.bpj.2015.03.054</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457043">4457043</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/25992725">25992725</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Biophysical+Journal&rft.atitle=Identification+of+the+first+sodium+binding+site+of+the+phosphate+cotransporter+NaPi-IIa+%28SLC34A1%29&rft.volume=108&rft.issue=10&rft.pages=2465-80&rft.date=2015-05&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4457043%23id-name%3DPMC&rft_id=info%3Apmid%2F25992725&rft_id=info%3Adoi%2F10.1016%2Fj.bpj.2015.03.054&rft.aulast=Fenollar-Ferrer&rft.aufirst=C&rft.au=Forster%2C+IC&rft.au=Patti%2C+M&rft.au=Knoepfel%2C+T&rft.au=Werner%2C+A&rft.au=Forrest%2C+LR&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4457043&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASodium%2Fphosphate+cotransporter" class="Z3988"></span></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sodium/phosphate_cotransporter&action=edit&section=11" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="http://www.tcdb.org/">Transporter Classification Database</a></li> <li><a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?name=Sodium-Phosphate+Cotransporter+Proteins">Sodium-Phosphate+Cotransporter+Proteins</a> at the U.S. National Library of Medicine <a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">Medical Subject Headings</a> (MeSH)</li></ul>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; 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