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Thomas Shenk - Wikipedia

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<div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"><span class="mw-redirectedfrom">(Redirected from <a href="/w/index.php?title=Thomas_E._Shenk&amp;redirect=no" class="mw-redirect" title="Thomas E. 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Shenk</div></th></tr><tr><th scope="row" class="infobox-label">Nationality</th><td class="infobox-data category"><a href="/wiki/Americans" title="Americans">American</a></td></tr><tr><th scope="row" class="infobox-label">Alma&#160;mater</th><td class="infobox-data"><a href="/wiki/University_of_Detroit" class="mw-redirect" title="University of Detroit">University of Detroit</a><br /><a href="/wiki/Rutgers_University" title="Rutgers University">Rutgers University</a></td></tr><tr><th scope="row" class="infobox-label">Known&#160;for</th><td class="infobox-data"><a href="/wiki/Human_cytomegalovirus" class="mw-redirect" title="Human cytomegalovirus">Human cytomegalovirus</a></td></tr><tr><td colspan="2" class="infobox-full-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><b>Scientific career</b></td></tr><tr><th scope="row" class="infobox-label">Institutions</th><td class="infobox-data"><a href="/wiki/Princeton_University" title="Princeton University">Princeton University</a></td></tr><tr style="display:none"><td colspan="2"> </td></tr></tbody></table> <p><b>Thomas Eugene Shenk</b> (born 1947) is an American virologist. He is currently Emeritus Professor of Life Sciences in the Department of <a href="/wiki/Molecular_Biology" class="mw-redirect" title="Molecular Biology">Molecular Biology</a> at <a href="/wiki/Princeton_University" title="Princeton University">Princeton University</a>.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Career">Career</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Thomas_Shenk&amp;action=edit&amp;section=1" title="Edit section: Career"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Shenk received a BS in biology from the <a href="/wiki/University_of_Detroit" class="mw-redirect" title="University of Detroit">University of Detroit</a>, and earned a Ph.D. in <a href="/wiki/Microbiology" title="Microbiology">Microbiology</a> under the mentorship of Victor Stollar from <a href="/wiki/Rutgers_University" title="Rutgers University">Rutgers University</a>.<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">&#91;</span>2<span class="cite-bracket">&#93;</span></a></sup> He then trained as a postdoctoral fellow with Paul Berg at Stanford University School of Medicine. </p><p>He was Assistant Professor of Microbiology at the University of Connecticut Health Science Center (1975–80) and Professor of Microbiology at the State University of New York at Stony Brook (1980–84). </p><p>In 1984, Shenk moved to Princeton University as the James A. Elkins Jr. Professor of Life Sciences and a founding member of the Department of Molecular Biology. He served as Chair of that department (1996-2004), and as a founding Co-Director of the Princeton University Program in Global Health and Health Policy (2008–15). Shenk was named an American Cancer Society Research Professor (1986-), and was appointed an Investigator of the Howard Hughes Medical Institute (1989–99) during his years at Princeton.<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">&#91;</span>3<span class="cite-bracket">&#93;</span></a></sup> </p><p>Shenk is a virologist whose work has focused on the DNA tumor virus, adenovirus, and the herpesvirus, human cytomegalovirus. In the adenovirus system, he developed technologies for introducing mutations into the viral genome and employed that technology to elucidate the functions of viral genes and their oncogenic impact on the infected cell. For cytomegalovirus he has applied genetic, transcriptomic, metabolomic and proteomic approaches to dissect viral gene functions and their roles during active viral growth and latency. </p><p>He served as President of the American Society for Virology (1997–98) and the American Society for Microbiology (2003–04). He has also served as Editor-in-Chief of the Journal of Virology (1994-2002) and as Chair of the American Society for Microbiology Publications Board (2008–17). He has also served on not-for-profit boards including the Fox Chase Cancer Center (2009–15)<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">&#91;</span>4<span class="cite-bracket">&#93;</span></a></sup> the Hepatitis B Foundation (2012-) and the Blumberg Institute (2015-). </p><p>In addition to academia, Shenk has pursued interests in the biotechnology and pharmaceutical industries. He has served as a director at biotech companies, including Novalon Pharmaceutical Corp. (1996-2000), Cell Genesys, Inc. (2001–09), CV Therapeutics, Inc. (2005-2009), Vical, Inc. (2015-2019) and MeiraGTx, Ltd (2015-); and he served on the board of directors of the pharmaceutical company, Merck and Co. (2001–12).<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">&#91;</span>5<span class="cite-bracket">&#93;</span></a></sup> Shenk cofounded several biotech companies, most recently Evrys Bio, LLC, that is developing sirtuin 2 modulators as broad-spectrum antivirals, where he chairs the board of managers (2013-); and PMV Pharma, Inc., that is developing therapeutics designed to reactivate defective p53 tumor suppressor proteins, where he serves on the scientific advisory board (2013-). </p><p>In 2021, Shenk transferred to Emeritus status within the Princeton department of Molecular Biology.<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">&#91;</span>6<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Awards_and_honors">Awards and honors</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Thomas_Shenk&amp;action=edit&amp;section=2" title="Edit section: Awards and honors"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Shenk received the Eli Lilly and Company Award in Microbiology and Immunology from the American Society for Microbiology in 1982 for his work on adenovirus gene functions. He was awarded the Arthur Kornberg and Paul Berg Lifetime Achievement Award in Biomedical Sciences from the Stanford University School of Medicine Alumni Association in 2011. </p><p>He was elected to fellowship in the American Academy of Microbiology in 1993, membership in the U.S. National Academy of Sciences in 1996,<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">&#91;</span>7<span class="cite-bracket">&#93;</span></a></sup> and membership the U.S. National Academy of Medicine in 1996. He was elected a fellow of the American Academy of Arts and Sciences in 2002,<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">&#91;</span>8<span class="cite-bracket">&#93;</span></a></sup> a member of the American Philosophical Society in 2015 and a fellow of the National Academy of Inventors in 2018. </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Thomas_Shenk&amp;action=edit&amp;section=3" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-1">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://scholar.princeton.edu/shenklab/people/thomas-shenk">"Thomas Shenk profile"</a>. <i>Shenk Lab Website</i><span class="reference-accessdate">. Retrieved <span class="nowrap">5 January</span> 2022</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=Shenk+Lab+Website&amp;rft.atitle=Thomas+Shenk+profile&amp;rft_id=https%3A%2F%2Fscholar.princeton.edu%2Fshenklab%2Fpeople%2Fthomas-shenk&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AThomas+Shenk" class="Z3988"></span></span> </li> <li id="cite_note-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-2">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://gsbs.rutgers.edu/alumni/shenk2013.html">"Graduate School of Biomedical Sciences Alumni Association- Thomas Shenk"</a>. <i>Rutgers Graduate School of Biomedical Sciences</i><span class="reference-accessdate">. Retrieved <span class="nowrap">5 January</span> 2022</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=Rutgers+Graduate+School+of+Biomedical+Sciences&amp;rft.atitle=Graduate+School+of+Biomedical+Sciences+Alumni+Association-+Thomas+Shenk&amp;rft_id=http%3A%2F%2Fgsbs.rutgers.edu%2Falumni%2Fshenk2013.html&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AThomas+Shenk" class="Z3988"></span></span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.hhmi.org/scientists/thomas-e-shenk">"Thomas E. Shenk, PhD"</a>. <i>HHMI</i><span class="reference-accessdate">. Retrieved <span class="nowrap">5 January</span> 2022</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=HHMI&amp;rft.atitle=Thomas+E.+Shenk%2C+PhD&amp;rft_id=https%3A%2F%2Fwww.hhmi.org%2Fscientists%2Fthomas-e-shenk&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AThomas+Shenk" class="Z3988"></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.foxchase.org/sites/fccc/files/fccc-annual-report-2014.pdf">"Fox Chase Cancer Center Annual Report (2014)"</a> <span class="cs1-format">(PDF)</span><span class="reference-accessdate">. Retrieved <span class="nowrap">5 January</span> 2022</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&amp;rft.genre=unknown&amp;rft.btitle=Fox+Chase+Cancer+Center+Annual+Report+%282014%29&amp;rft_id=https%3A%2F%2Fwww.foxchase.org%2Fsites%2Ffccc%2Ffiles%2Ffccc-annual-report-2014.pdf&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AThomas+Shenk" class="Z3988"></span></span> </li> <li id="cite_note-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-5">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.merck.com/news/thomas-e-shenk-to-retire-from-mercks-board-of-directors/">"Thomas E. Shenk To Retire From Merck's Board of Directors"</a>. <i>Merck website</i><span class="reference-accessdate">. Retrieved <span class="nowrap">5 January</span> 2022</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=Merck+website&amp;rft.atitle=Thomas+E.+Shenk+To+Retire+From+Merck%E2%80%99s+Board+of+Directors&amp;rft_id=https%3A%2F%2Fwww.merck.com%2Fnews%2Fthomas-e-shenk-to-retire-from-mercks-board-of-directors%2F&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AThomas+Shenk" class="Z3988"></span></span> </li> <li id="cite_note-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-6">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://molbio.princeton.edu/news/two-faculty-members-transfer-emeritus-status">"Two Faculty Members Transfer to Emeritus Status"</a>. <i>Princeton University- Department of Molecular Biology</i><span class="reference-accessdate">. Retrieved <span class="nowrap">5 January</span> 2022</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=Princeton+University-+Department+of+Molecular+Biology&amp;rft.atitle=Two+Faculty+Members+Transfer+to+Emeritus+Status&amp;rft_id=https%3A%2F%2Fmolbio.princeton.edu%2Fnews%2Ftwo-faculty-members-transfer-emeritus-status&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AThomas+Shenk" class="Z3988"></span></span> </li> <li id="cite_note-7"><span class="mw-cite-backlink"><b><a href="#cite_ref-7">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.nasonline.org/member-directory/members/40205.html">"Thomas E. Shenk (member profile)"</a>. <i>National Academy of Sciences member directory</i><span class="reference-accessdate">. Retrieved <span class="nowrap">5 January</span> 2022</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=National+Academy+of+Sciences+member+directory&amp;rft.atitle=Thomas+E.+Shenk+%28member+profile%29&amp;rft_id=http%3A%2F%2Fwww.nasonline.org%2Fmember-directory%2Fmembers%2F40205.html&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AThomas+Shenk" class="Z3988"></span></span> </li> <li id="cite_note-8"><span class="mw-cite-backlink"><b><a href="#cite_ref-8">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.amacad.org/person/thomas-e-shenk">"Thomas E. Shenk profile"</a>. <i>American Academy of Arts and Sciences member directory</i><span class="reference-accessdate">. Retrieved <span class="nowrap">5 January</span> 2022</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=unknown&amp;rft.jtitle=American+Academy+of+Arts+and+Sciences+member+directory&amp;rft.atitle=Thomas+E.+Shenk+profile&amp;rft_id=https%3A%2F%2Fwww.amacad.org%2Fperson%2Fthomas-e-shenk&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AThomas+Shenk" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Thomas_Shenk&amp;action=edit&amp;section=4" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="https://scholar.princeton.edu/shenklab/research">Current research at Princeton University</a></li> <li><a rel="nofollow" class="external text" href="https://molbio.princeton.edu/research/labs/shenk-lab">Faculty profile at Princeton University</a></li></ul> <!-- NewPP limit report Parsed by mw‐web.eqiad.main‐5dc468848‐g8cx2 Cached time: 20241122160209 Cache expiry: 2592000 Reduced expiry: false Complications: [vary‐revision‐sha1, show‐toc] CPU time usage: 0.330 seconds Real time usage: 0.493 seconds Preprocessor visited node count: 2199/1000000 Post‐expand include size: 20810/2097152 bytes Template argument size: 1176/2097152 bytes Highest expansion depth: 13/100 Expensive parser function count: 2/500 Unstrip recursion depth: 1/20 Unstrip post‐expand size: 31021/5000000 bytes Lua time usage: 0.232/10.000 seconds Lua memory usage: 5963856/52428800 bytes Number of Wikibase entities loaded: 1/400 --> <!-- Transclusion expansion time report (%,ms,calls,template) 100.00% 470.166 1 -total 25.96% 122.032 1 Template:Infobox_scientist 25.74% 121.016 1 Template:Reflist 21.95% 103.214 8 Template:Cite_web 21.87% 102.806 1 Template:Short_description 21.59% 101.490 1 Template:More_footnotes_needed 20.20% 94.989 1 Template:Ambox 13.34% 62.743 19 Template:Main_other 10.13% 47.651 1 Template:SDcat 8.25% 38.784 2 Template:Pagetype --> <!-- Saved in parser cache with key enwiki:pcache:idhash:5238776-0!canonical and timestamp 20241122160209 and revision id 1179701102. 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