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MSc</h3> <p class="profile__title" itemprop="jobTitle">Maternal-Fetal Medicine Specialist </br> Investigator, Vincent Center for Reproductive Biology</p> </div> <p class="profile__image"> <img alt="Dr. Andrea Edlow" itemprop="image" srcset="/assets/images/contributors/andrea_edlow_advances.png, /assets/images/contributors/andrea_edlow_advances_2x.png 2x" src="/assets/images/contributors/andrea_edlow_advances.png"> </p> </div> </div> </aside> <div class="layout-columns__main -padding--vertical -padding--horizontal" dcrname ="iwDCR0_141323"> <div class="layout-columns__main__content"> <h2 class="heading-h4">Posts by Andrea Edlow, MD, MSc</h2> <ul class="content-tease__list"> <li class="content-tease__item"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/obgyn/journal.aspx?id=2633" itemprop="url"> Multicomponent Program Improved Perinatal Mental Health in an Urban Cohort During COVID-19</a> </h3> <p itemprop="description"> <p><span>Massachusetts General Hospital researchers demonstrated that a community-based perinatal program combining patient navigation, behavioral healthcare and emergency relief was associated with improvements in depressive symptoms and perceived stress, as well as improvement in anxiety symptoms for a subset of participants.</span></p></p> <p class="content-tease__related"> <a href="/obgyn/specialty.aspx?id=1006" itemprop="relatedLink">OB/GYN</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2024-07-03" itemprop="datePublished">July 3, 2024</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/endocrinology/journal.aspx?id=2576" itemprop="url"> In Utero Exposure to SARS-CoV-2 May Increase the Risk of Cardiometabolic Disease</a> </h3> <p itemprop="description"> <p><span>Massachusetts General Hospital researchers found that infants who have in utero exposure to maternal SARS-CoV-2 exhibit lower birth weight followed by accelerated weight gain in the first year of life, a pattern thought to increase the risk of obesity and cardiometabolic disease in childhood and adulthood.</span></p></p> <p class="content-tease__related"> <a href="/endocrinology/specialty.aspx?id=1015" itemprop="relatedLink">Endocrinology</a>, <a href="/obgyn/specialty.aspx?id=1006" itemprop="relatedLink">OB/GYN</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2024-01-23" itemprop="datePublished">January 23, 2024</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/obgyn/journal.aspx?id=2564" itemprop="url"> Sex-specific Impact of Maternal Obesity on Fetal Placental Macrophages and Cord Blood Triglycerides</a> </h3> <p itemprop="description"> <p>Lydia<span>L. Shook, MD, Andrea G. Edlow, MD, MSc, and colleagues observed that maternal obesity was more immune-activating in the male than female placenta. They also observed sexual dimorphism in placental lipid transfer. These findings may explain sex differences in cardiometabolic disease risk in obesity-exposed offspring.</span></p></p> <p class="content-tease__related"> <a href="/obgyn/specialty.aspx?id=1006" itemprop="relatedLink">OB/GYN</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2023-12-26" itemprop="datePublished">December 26, 2023</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/obgyn/journal.aspx?id=2292" itemprop="url"> COVID-19 Vaccination During Pregnancy Produces Durable Antibodies in Young Infants</a> </h3> <p itemprop="description"> <p><span>Lydia L. Shook, MD, Andrea G. Edlow, MD, MSc, and colleagues found that at age six months, infants born to mothers vaccinated against COVID-19 during pregnancy were significantly more likely to have detectable antibodies to the SARS-CoV-2 spike protein than infants whose mothers became infected with SARS-CoV-2 during pregnancy.</span></p></p> <p class="content-tease__related"> <a href="/obgyn/specialty.aspx?id=1006" itemprop="relatedLink">OB/GYN</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2022-08-19" itemprop="datePublished">August 19, 2022</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/obgyn/article.aspx?id=1477" itemprop="url"> Studying SARS-CoV-2 and mRNA Vaccines in Mothers and Babies</a> </h3> <p itemprop="description"> <p><span>Researchers at Mass General are studying the effects of SARS-CoV-2 infection and mRNA vaccines in pregnant and lactating individuals, as well as neonates.</span></p></p> <p class="content-tease__related"> <a href="/obgyn/specialty.aspx?id=1006" itemprop="relatedLink">OB/GYN</a> </p> <p class="content-metadata"> <span class="content-metadata__media -article">Article</span> <time class="date" datetime="2022-05-12" itemprop="datePublished">May 12, 2022</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/obgyn/journal.aspx?id=2158" itemprop="url"> Protection After First Dose of COVID-19 mRNA Vaccines Slower to Develop in Pregnant Women</a> </h3> <p itemprop="description"> <p><span>Andrea Edlow, MD, MSc, of the Department of Obstetrics and Gynecology, and colleagues discovered antibody profiles induced by the COVID-19 mRNA vaccines develops more slowly than normal in pregnant/lactating women. This highlights the critical need to administer two doses at the recommended interval in pregnancy.</span></p></p> <p class="content-tease__related"> <a href="/obgyn/specialty.aspx?id=1006" itemprop="relatedLink">OB/GYN</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2022-02-16" itemprop="datePublished">February 16, 2022</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/obgyn/journal.aspx?id=2100" itemprop="url"> Maternal and Placental Immune Responses to SARS-CoV-2 Differ by Fetal Sex</a> </h3> <p itemprop="description"> <p>Massachusetts General Hospital researchers present evidence that fetal sex plays a key role in modifying maternal humoral responses and placental innate and adaptive immune responses. They found significantly reduced transfer of SARS-CoV-2–specific antibodies to male fetuses.</p></p> <p class="content-tease__related"> <a href="/obgyn/specialty.aspx?id=1006" itemprop="relatedLink">OB/GYN</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2021-12-01" itemprop="datePublished">December 1, 2021</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/research-and-innovation/journal.aspx?id=1989" itemprop="url"> Novel Cell Models Allow Study of How COVID-19, Other Maternal Exposures Affect the Fetal Brain</a> </h3> <p itemprop="description"> <p>By reprogramming neonatal cord blood mononuclear cells, researchers at Massachusetts General Hospital have created patient-specific models of fetal microglia-mediated synaptic pruning. These will permit non-invasive investigation of how maternal exposures, including SARS-CoV-2 infection, affect the fetal brain.</p></p> <p class="content-tease__related"> <a href="/neuro/specialty.aspx?id=1004" itemprop="relatedLink">Neuroscience</a>, <a href="/obgyn/specialty.aspx?id=1006" itemprop="relatedLink">OB/GYN</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2021-07-07" itemprop="datePublished">July 7, 2021</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/obgyn/journal.aspx?id=1936" itemprop="url"> COVID-19 mRNA Vaccination of Pregnant and Lactating Women Generates Robust Maternal Immunity, May Provide Protection for Newborns</a> </h3> <p itemprop="description"> <p>Andrea G. Edlow, MD, MSc, of the Department of Obstetrics and Gynecology, has provided the first evidence from a large cohort that immunogenicity and reactogenicity to the COVID-19 mRNA vaccines are similar to that observed in non-pregnant women, and immune transfer to the neonate occurs via placenta and breastmilk.</p></p> <p class="content-tease__related"> <a href="/obgyn/specialty.aspx?id=1006" itemprop="relatedLink">OB/GYN</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2021-05-14" itemprop="datePublished">May 14, 2021</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/obgyn/journal.aspx?id=1927" itemprop="url"> Placental Transfer of SARS-CoV-2 Antibodies Is Compromised</a> </h3> <p itemprop="description"> <p>In a study that has implications for vaccine development, Andrea G. Edlow, MD, MSc, of the Vincent Center for Reproductive Biology, and Galit Alter, PhD, of the Ragon Institute, found the transfer of SARS-CoV-2 antibodies to cord blood is compromised in those infected in the third trimester.</p></p> <p class="content-tease__related"> <a href="/obgyn/specialty.aspx?id=1006" itemprop="relatedLink">OB/GYN</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2021-05-07" itemprop="datePublished">May 7, 2021</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/obgyn/journal.aspx?id=1823" itemprop="url"> Vertical Transmission of SARS-CoV-2 Is Rare but Immunity Is Compromised in Neonates</a> </h3> <p itemprop="description"> <p>Based on data from a prospective cohort study, Andrea G. Edlow, MD, MSc, and colleagues caution that transplacental transfer of anti–SARS-CoV-2 antibodies is inefficient, which may leave neonates at risk of infection.</p></p> <p class="content-tease__related"> <a href="/obgyn/specialty.aspx?id=1006" itemprop="relatedLink">OB/GYN</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2021-01-27" itemprop="datePublished">January 27, 2021</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/obgyn/journal.aspx?id=1746" itemprop="url"> Review: Mechanisms of Maternal Obesity with Neuromorbidity in Offspring</a> </h3> <p itemprop="description"> <p>Studies are uncovering how prenatal and lactational exposure to maternal obesity leads to neurodevelopmental and psychiatric disorders in offspring.</p></p> <p class="content-tease__related"> <a href="/digestive-health/specialty.aspx?id=1007" itemprop="relatedLink">Digestive Health</a>, <a href="/obgyn/specialty.aspx?id=1006" itemprop="relatedLink">OB/GYN</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2020-11-17" itemprop="datePublished">November 17, 2020</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/obgyn/journal.aspx?id=1681" itemprop="url"> Review: Cardiometabolic Effects of Exposure to Maternal Obesity</a> </h3> <p itemprop="description"> <p>Perinatal exposure to maternal obesity has lasting adverse cardiometabolic effects on children, including increased risk of cardiovascular mortality in adulthood.</p></p> <p class="content-tease__related"> <a href="/cardiovascular/specialty.aspx?id=1002" itemprop="relatedLink">Cardiovascular</a>, <a href="/obgyn/specialty.aspx?id=1006" itemprop="relatedLink">OB/GYN</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2020-09-22" itemprop="datePublished">September 22, 2020</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/obgyn/journal.aspx?id=1473" itemprop="url"> Composition of Maternal Diet Influences Fetal Brain Gene Expression and Offspring Behavior in Mice</a> </h3> <p itemprop="description"> <p>Even in the absence of maternal over- or undernutrition, the choice of diet for pregnant mice significantly affected fetal brain development and the neonatal and adult behavior of offspring.</p></p> <p class="content-tease__related"> <a href="/neuro/specialty.aspx?id=1004" itemprop="relatedLink">Neuroscience</a>, <a href="/obgyn/specialty.aspx?id=1006" itemprop="relatedLink">OB/GYN</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2020-02-11" itemprop="datePublished">February 11, 2020</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/obgyn/article.aspx?id=1086" itemprop="url"> Exploring the Relationship Between Maternal Obesity and Adverse Fetal Neurodevelopment</a> </h3> <p itemprop="description"> <p>Evidence from a pilot study suggests that maternal obesity primes macrophages in the fetal brain and placenta to overrespond to immune challenge. Male fetuses may be more vulnerable to this proinflammatory priming.</p></p> <p class="content-tease__related"> <a href="/obgyn/specialty.aspx?id=1006" itemprop="relatedLink">OB/GYN</a> </p> <p class="content-metadata"> <span class="content-metadata__media -article">Article</span> <time class="date" datetime="2019-04-02" itemprop="datePublished">April 2, 2019</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/obgyn/journal.aspx?id=1217" itemprop="url"> Placental Macrophages Provide Information About Fetal Brain Microglia</a> </h3> <p itemprop="description"> <p>Researchers have shown that a subset of placental immune cells may provide insight into the behavior of microglia in the fetal brain in the setting of maternal obesity. This marks a first step toward identifying a biomarker of fetal neuroimmune activation that is accessible during pregnancy or immediately after birth.</p></p> <p class="content-tease__related"> <a href="/neuro/specialty.aspx?id=1004" itemprop="relatedLink">Neuroscience</a>, <a href="/obgyn/specialty.aspx?id=1006" itemprop="relatedLink">OB/GYN</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2019-03-05" itemprop="datePublished">March 5, 2019</time> </p> </div> </li> </ul> </div> </div> </section> <section class="-padding--vertical -padding--horizontal"> <div class="content-container -width--medium -centered"> <h2>Biography</h2> <p> <p>Andrea Edlow, MD, MSc, received her BA in history from Yale University, followed by a master鈥檚 degree in economic and social history from Oxford University. She attended medical school at the University of Pennsylvania School of Medicine, and completed OB/GYN residency at the Brigham and Women鈥檚 Hospital/Massachusetts General Hospital Combined Residency program. She completed her maternal-fetal medicine fellowship at Tufts Medical Center in Boston.</p><p> Dr. Edlow is currently an assistant professor of obstetrics, gynecology and reproductive biology at Harvard Medical School, and maternal-fetal medicine staff at Massachusetts General Hospital. She runs her own <a href="https://www.massgeneral.org/vcrb/research/researchlab.aspx?id=1808">research lab</a> in the Vincent Center for Reproductive Biology. She is completing the 5th year of a K12 award through the Reproductive Scientist Development Program/NICHD. Her research is also funded by the March of Dimes, American College of OB/GYN, American Board of OB/GYN, the Burroughs-Wellcome Fund, the Nutrition Obesity Research Center at Harvard,and the Boston Area Diabetes and Endocrinology Research Center. Dr. Edlow鈥檚 research focuses on the effects of maternal obesity on fetal brain development and offspring behavior. </p></p> <p class="fat-link__wrapper u-text-right"> <a class="fat-link -caret -large" href="https://www.massgeneral.org/doctors/20225/Andrea-Edlow">View full profile</a> </p> </div> </section> <div class="content-container -width--xwide -centered specialty-block__wrapper" id="specialty-block"> <style> #specialty-block .specialty-block__image { /* 540px */ background-image: url(/assets/raw/specialty-block/specialty-callout_obgyn_advances1x.jpg); } only screen and (-webkit-min-device-pixel-ratio: 2), only screen and (min--moz-device-pixel-ratio: 2), only screen and (-moz-min-device-pixel-ratio: 2), only screen and (-o-min-device-pixel-ratio: 2/1), only screen and (min-device-pixel-ratio: 2), only screen and (min-resolution: 192dpi), only screen and (min-resolution: 2dppx) { #specialty-block .specialty-block__image { /* 1080 width */ background-image: url(/assets/raw/specialty-block/specialty-callout_obgyn_advances2x.jpg); } } /* </style> <span class="specialty-block__image"></span> <div class="specialty-block"> <h2 class="section-heading"> Obstetrics & Gynecology Care at Mass General</h2> The Mass General Department of Obstetrics & Gynecology offers the highest level of care to women. 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