Explore Statins for Primary Prevention of Cardiovascular Disease Guidelines from JAMA Network

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Prevention of Cardiovascular Disease</h1> <h2>From the USPSTF and the JAMA Network. <a href="https://jamanetwork.com/journals/jama/fullarticle/2484317" style="color:#0093c0;" target="_blank">Learn more</a>.</h2> <p>In 2016, the United States Preventive Services Task Force updated its recommendations on the use of statins to prevent cardiovascular disease in adults without prior cardiovascular events. The Task Force recommends use of low-to-moderate dose statins in adults aged 40 to 75 who have</p> <ul> <li> One or more risk factors (hypertension, diabetes, smoking, dyslipidemia) </li> </ul> <ul> <li> A calculated 10-year CVD event risk of 10% or greater </li> </ul> <p>The Task Force recommends that clinicians selectively offer low-to-moderate doses statins to adults without prior cardiovascular events who have</p> <ul> <li> One or more risk factors (hypertension, diabetes, smoking, dyslipidemia) </li> </ul> <ul> <li> A calculated 10-year CVD event risk of 7.5-10% or greater </li> </ul> <div id="branding-image-mobile"> <a href="https://jamanetwork.com/journals/jama/fullarticle/2484317" target="_blank"><img class="u-max-full-width" alt="cropped feature image alt tag" src="images/JAMA-and-USPSTF-row-ko-700w.png" style="background-color:#999; border: 1px solid #bbb;"/></a> <a href="https://jamanetwork.com/journals/jama/fullarticle/2484317" style="color:#0093c0;" target="_blank">Read more about the USPSTF and JAMA Network collaboration.</a> </div> </div> </div> </div> </div> </div> <div><a class="anchor" id="related"></a></a> <div class="container flexible-rows"> <h3 class="ymal-head">Related Articles</h3> <div class="items-container simple-items"> <div class="item section"> <img src="images/USPSTF-no-tagline-RGB-spaced.png" alt="section image description" style="background-color: #fff;"/> <h3>Recommendation Statement</h3> <h5><a href="https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2016.15450" target="_blank">Statin Use for the Primary Prevention of Cardiovascular Disease in Adults – USPSTF Recommendation Statement</a></h5> <h5><a href="https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2015.15629" target="_blank">Statins for Prevention of Cardiovascular Disease in Adults: Evidence Report and Systematic Review for the US Preventive Services Task Force</a></h5> <h5><a href="https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2016.15085" target="_blank">Statins for Primary Prevention: The Debate Is Intense, but the Data Are Weak</a></h5> <h5><a href="https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2016.15087" target="_blank">Interpretation and Use of Another Statin Guideline</a></h5> <h5><a href="https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2016.15094" target="_blank">Evolving Approaches for Statins in Primary Prevention: Progress, but Questions Remain</a></h5> <h5><a href="https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2016.16650" target="_blank">Patient Page: Lipid Disorders: Screening and Treatment</a></h5> </div> <div class="item section"> <img src="images/statins-peer-500.jpg" alt="section image description"/> <h3>JAMA Cardiology</h3> <h5><a href="https://jamanetwork.com/journals/jamacardiology/fullarticle/10.1001/jamacardio.2016.4710" target="_blank">Perspective on Trends in Statin Use</a></h5> <h5><a href="https://jamanetwork.com/journals/jamacardiology/fullarticle/10.1001/jamacardio.2016.4700" target="_blank">US National Trends in US Statin Use and Expenditures</a></h5> <h5><a href="https://jamanetwork.com/journals/jamacardiology/fullarticle/10.1001/jamacardio.2016.4709" target="_blank">Statins—Almost 30 Years of Use in the United States and Still Not Quite There</a></h5> </div> <div class="item section"> <img src="images/uspstf-resources-500.png" alt="section image description"/> <h3>Related Resources</h3> <h5><a href="http://content.onlinejacc.org/article.aspx?articleid=1879710" target="_blank">2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults</a></h5> <h5><a href="http://tools.acc.org/ASCVD-Risk-Estimator/" target="_blank">ACC/AHA Pooled Cohort ASCVD Risk Calculator</a></h5> <h5><a href="http://www.onlinecjc.ca/article/S0828-282X(16)30732-2/abstract?cc=y=" target="_blank">2016 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in the Adult</a></h5> <h5><a href="https://www.nice.org.uk/guidance/cg181" target="_blank">2014 NICE Clinical Guideline: Cardiovascular disease: risk assessment and reduction, including lipid modification</a></h5> </div> <div class="item section"> <img src="images/uspstf-editorial-500.png" alt="section image description"/> <h3>Editorial</h3> <h5><a href="https://jamanetwork.com/journals/jama/fullarticle/2484317"><em>JAMA</em> Welcomes the US Preventive Services Task Force</a></h5> </div> </div> </div> </div> <div class="section-background-odd"><a class="anchor" id="multimedia"></a> <div class="container"> <h3 class="ymal-head">Related Multimedia</h3> <div class="row"> <div class="one-half column player-margin"> <div style="display: block; position: relative; max-width: 100%;"> <div style="padding-top: 56.25%;"> <video data-video-id="5179921910001" data-account="864352215001" data-player="rkojA32yM" data-embed="default" data-application-id class="video-js" controls style="width: 100%; height: 100%; position: absolute; top: 0px; bottom: 0px; right: 0px; left: 0px;"> </video> <script src="//players.brightcove.net/864352215001/rkojA32yM_default/index.min.js"></script> </div> </div> <p class="multimedia-caption">The JAMA Report: Statin Use for Primary Prevention of Cardiovascular Disease in Adults </p> </div> <div class="one-half column player-margin"> <div style="display: block; position: relative; max-width: 100%;"> <div style="padding-top: 56.25%;"> <video data-video-id="5179921411001" data-account="864352215001" data-player="rkojA32yM" data-embed="default" data-application-id class="video-js" controls style="width: 100%; height: 100%; position: absolute; top: 0px; bottom: 0px; right: 0px; left: 0px;"> </video> <script src="//players.brightcove.net/864352215001/rkojA32yM_default/index.min.js"></script> </div> </div> <p class="multimedia-caption">Author Interview: Dr Douglas Owens on Statin Use for Primary Prevention of Cardiovascular Disease in Adults </p> </div> </div> <div class="row"> <div class="one-half column player-margin"> <div style="display: block; position: relative; max-width: 100%;"> <div style="padding-top: 56.25%;"> <video data-video-id="5164350481001" data-account="864352215001" data-player="rkojA32yM" data-embed="default" data-application-id class="video-js" controls style="width: 100%; height: 100%; position: absolute; top: 0px; bottom: 0px; right: 0px; left: 0px;"> </video> <script src="//players.brightcove.net/864352215001/rkojA32yM_default/index.min.js"></script> </div> </div> <p class="multimedia-caption">Whiteboard video: Statin Use for Primary Prevention of Cardiovascular Disease in Adults </p> </div> <div class="one-half column player-margin">  </div> </div> <div class="row"> <div class="twelve columns"> <iframe class="audioPlayer" style="border: none" src="https://html5-player.libsyn.com/embed/episode/id/4823955/theme/custom/autonext/no/thumbnail/yes/autoplay/no/preload/no/no_addthis/no/direction/backward/no-cache/true/render-playlist/no/custom-color/d71635/" scrolling="no" allowfullscreen webkitallowfullscreen mozallowfullscreen oallowfullscreen msallowfullscreen></iframe> <p class="multimedia-caption">JAMA Author Interview with Douglas K. Owens, MD, MS </p> </a> </div> </div> </div> </div> <div class="section-background-odd"><a class="anchor" id="more"></a> <div class="container flexible-rows"> <h3 class="ymal-head">More Statin and Lipid Articles From the JAMA Network</h3> <div class="items-container simple-items"> <div class="item ymal car"> <h5><a href="https://jamanetwork.com/journals/jamacardiology/fullarticle/2589153" target="_blank">Trends in Total Cholesterol, Triglycerides, and Low-Density Lipoprotein in US Adults, 1999-2014</a></h5> <p class="authors">Asher Rosinger and Coauthors</p> <p>JAMA Cardiology | <em>Research Letter, November 30, 2016</em></p> </div> <div class="item ymal car"> <h5><a href="https://jamanetwork.com/journals/jamacardiology/fullarticle/2589152" target="_blank">Role of Nonstatin Therapies for Low-Density Lipoprotein Cholesterol Lowering in Management of Atherosclerotic Cardiovascular Disease Risk</a></h5> <p class="authors">Donald M. Lloyd-Jones</p> <p>JAMA Cardiology | <em>JAMA Cardiology Clinical Guidelines Synopsis, November 30, 2016</em></p> </div> <div class="item ymal car"> <h5><a href="https://jamanetwork.com/journals/jamacardiology/fullarticle/2580531" target="_blank">Association Between Intensity of Statin Therapy and Mortality in Patients With Atherosclerotic Cardiovascular Disease</a></h5> <p class="authors">Fatima Rodriguez and Coauthors</p> <p>JAMA Cardiology | <em>Original Investigation, November 9, 2016</em></p> </div> <div class="item ymal car"> <h5><a href="https://jamanetwork.com/journals/jamacardiology/fullarticle/2580529" target="_blank">High-Intensity Statins for Secondary Prevention</a></h5> <p class="authors">Robert O. Bonow and Clyde W. Yancy</p> <p>JAMA Cardiology | <em>Editor's Note, November 9, 2016</em></p> </div> <div class="item ymal"> <h5><a href="https://jamanetwork.com/journals/jama/fullarticle/2565289" target="_blank">Association Between Low-Density Lipoprotein Cholesterol–Lowering Genetic Variants and Risk of Type 2 Diabetes: A Meta-analysis</a></h5> <p class="authors">Luca A. Lotta and Coauthors</p> <p>JAMA | <em>Original Investigation, October 4, 2016</em></p> </div> <div class="item ymal"> <h5><a href="https://jamanetwork.com/journals/jama/fullarticle/2556125" target="_blank">Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis</a></h5> <p class="authors">Michael G. Silverman and Coauthors</p> <p>JAMA | <em>Original Investigation, September 27, 2016</em></p> </div> <div class="item ymal car"> <h5><a href="https://jamanetwork.com/journals/jamacardiology/fullarticle/2532048" target="_blank">Comparison of ACC/AHA and ESC Guideline Recommendations Following Trial Evidence for Statin Use in Primary Prevention of Cardiovascular Disease: Results From the Population-Based Rotterdam Study</a></h5> <p class="authors">Jelena Pavlović and Coauthors</p> <p>JAMA Cardiology | <em>Brief Report, September 2016</em></p> </div> <div class="item ymal"> <h5><a href="https://jamanetwork.com/journals/jama/fullarticle/2544639" target="_blank">Cost-effectiveness of PCSK9 Inhibitor Therapy in Patients With Heterozygous Familial Hypercholesterolemia or Atherosclerotic Cardiovascular Disease</a></h5> <p class="authors">Dhruv S. Kazi and Coauthors</p> <p>JAMA | <em>Original Investigation, August 16, 2016</em></p> </div> <div class="item ymal"> <h5><a href="https://jamanetwork.com/journals/jama/fullarticle/2542642" target="_blank">Screening for Lipid Disorders in Children and Adolescents: US Preventive Services Task Force Recommendation Statement</a></h5> <p class="authors">US Preventive Services Task Force</p> <p>JAMA | <em>Recommendation Statement, August 9, 2016</em></p> </div> <div class="item ymal"> <h5><a href="https://jamanetwork.com/journals/jama/fullarticle/2542617" target="_blank">Lipid Screening in Children and Adolescents</a></h5> <p class="authors">Elaine M. Urbina and Sarah D. de Ferranti</p> <p>JAMA | <em>Editorial, August 9, 2016</em></p> </div> <div class="item ymal imd"> <h5><a href="https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2542437" target="_blank">Lipid Screening in Children: Low-Value Care</a></h5> <p class="authors">Thomas B. Newman and Coauthors</p> <p>JAMA Internal Medicine | <em>Editorial, October 2016</em></p> </div> <div class="item ymal ped"> <h5><a href="https://jamanetwork.com/journals/jamapediatrics/fullarticle/2541797" target="_blank">On the US Preventive Services Task Force Statement on Screening for Lipid Disorders in Children and Adolescents: One Step Forward and 2 Steps Sideways</a></h5> <p class="authors">Stephen R. 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Explore Statins for Primary Prevention of Cardiovascular Disease Guidelines from JAMA Network