CINXE.COM

<!DOCTYPE html> <html lang="en-US"> <head><meta charset="UTF-8" /><script>if(navigator.userAgent.match(/MSIE|Internet Explorer/i)||navigator.userAgent.match(/Trident\/7\..*?rv:11/i)){var href=document.location.href;if(!href.match(/[?&]nowprocket/)){if(href.indexOf("?")==-1){if(href.indexOf("#")==-1){document.location.href=href+"?nowprocket=1"}else{document.location.href=href.replace("#","?nowprocket=1#")}}else{if(href.indexOf("#")==-1){document.location.href=href+"&nowprocket=1"}else{document.location.href=href.replace("#","&nowprocket=1#")}}}}</script><script>(()=>{class RocketLazyLoadScripts{constructor(){this.v="1.2.6",this.triggerEvents=["keydown","mousedown","mousemove","touchmove","touchstart","touchend","wheel"],this.userEventHandler=this.t.bind(this),this.touchStartHandler=this.i.bind(this),this.touchMoveHandler=this.o.bind(this),this.touchEndHandler=this.h.bind(this),this.clickHandler=this.u.bind(this),this.interceptedClicks=[],this.interceptedClickListeners=[],this.l(this),window.addEventListener("pageshow",(t=>{this.persisted=t.persisted,this.everythingLoaded&&this.m()})),this.CSPIssue=sessionStorage.getItem("rocketCSPIssue"),document.addEventListener("securitypolicyviolation",(t=>{this.CSPIssue||"script-src-elem"!==t.violatedDirective||"data"!==t.blockedURI||(this.CSPIssue=!0,sessionStorage.setItem("rocketCSPIssue",!0))})),document.addEventListener("DOMContentLoaded",(()=>{this.k()})),this.delayedScripts={normal:[],async:[],defer:[]},this.trash=[],this.allJQueries=[]}p(t){document.hidden?t.t():(this.triggerEvents.forEach((e=>window.addEventListener(e,t.userEventHandler,{passive:!0}))),window.addEventListener("touchstart",t.touchStartHandler,{passive:!0}),window.addEventListener("mousedown",t.touchStartHandler),document.addEventListener("visibilitychange",t.userEventHandler))}_(){this.triggerEvents.forEach((t=>window.removeEventListener(t,this.userEventHandler,{passive:!0}))),document.removeEventListener("visibilitychange",this.userEventHandler)}i(t){"HTML"!==t.target.tagName&&(window.addEventListener("touchend",this.touchEndHandler),window.addEventListener("mouseup",this.touchEndHandler),window.addEventListener("touchmove",this.touchMoveHandler,{passive:!0}),window.addEventListener("mousemove",this.touchMoveHandler),t.target.addEventListener("click",this.clickHandler),this.L(t.target,!0),this.S(t.target,"onclick","rocket-onclick"),this.C())}o(t){window.removeEventListener("touchend",this.touchEndHandler),window.removeEventListener("mouseup",this.touchEndHandler),window.removeEventListener("touchmove",this.touchMoveHandler,{passive:!0}),window.removeEventListener("mousemove",this.touchMoveHandler),t.target.removeEventListener("click",this.clickHandler),this.L(t.target,!1),this.S(t.target,"rocket-onclick","onclick"),this.M()}h(){window.removeEventListener("touchend",this.touchEndHandler),window.removeEventListener("mouseup",this.touchEndHandler),window.removeEventListener("touchmove",this.touchMoveHandler,{passive:!0}),window.removeEventListener("mousemove",this.touchMoveHandler)}u(t){t.target.removeEventListener("click",this.clickHandler),this.L(t.target,!1),this.S(t.target,"rocket-onclick","onclick"),this.interceptedClicks.push(t),t.preventDefault(),t.stopPropagation(),t.stopImmediatePropagation(),this.M()}O(){window.removeEventListener("touchstart",this.touchStartHandler,{passive:!0}),window.removeEventListener("mousedown",this.touchStartHandler),this.interceptedClicks.forEach((t=>{t.target.dispatchEvent(new MouseEvent("click",{view:t.view,bubbles:!0,cancelable:!0}))}))}l(t){EventTarget.prototype.addEventListenerWPRocketBase=EventTarget.prototype.addEventListener,EventTarget.prototype.addEventListener=function(e,i,o){"click"!==e||t.windowLoaded||i===t.clickHandler||t.interceptedClickListeners.push({target:this,func:i,options:o}),(this||window).addEventListenerWPRocketBase(e,i,o)}}L(t,e){this.interceptedClickListeners.forEach((i=>{i.target===t&&(e?t.removeEventListener("click",i.func,i.options):t.addEventListener("click",i.func,i.options))})),t.parentNode!==document.documentElement&&this.L(t.parentNode,e)}D(){return new Promise((t=>{this.P?this.M=t:t()}))}C(){this.P=!0}M(){this.P=!1}S(t,e,i){t.hasAttribute&&t.hasAttribute(e)&&(event.target.setAttribute(i,event.target.getAttribute(e)),event.target.removeAttribute(e))}t(){this._(this),"loading"===document.readyState?document.addEventListener("DOMContentLoaded",this.R.bind(this)):this.R()}k(){let t=[];document.querySelectorAll("script[type=rocketlazyloadscript][data-rocket-src]").forEach((e=>{let i=e.getAttribute("data-rocket-src");if(i&&!i.startsWith("data:")){0===i.indexOf("//")&&(i=location.protocol+i);try{const o=new URL(i).origin;o!==location.origin&&t.push({src:o,crossOrigin:e.crossOrigin||"module"===e.getAttribute("data-rocket-type")})}catch(t){}}})),t=[...new Map(t.map((t=>[JSON.stringify(t),t]))).values()],this.T(t,"preconnect")}async R(){this.lastBreath=Date.now(),this.j(this),this.F(this),this.I(),this.W(),this.q(),await this.A(this.delayedScripts.normal),await this.A(this.delayedScripts.defer),await this.A(this.delayedScripts.async);try{await this.U(),await this.H(this),await this.J()}catch(t){console.error(t)}window.dispatchEvent(new Event("rocket-allScriptsLoaded")),this.everythingLoaded=!0,this.D().then((()=>{this.O()})),this.N()}W(){document.querySelectorAll("script[type=rocketlazyloadscript]").forEach((t=>{t.hasAttribute("data-rocket-src")?t.hasAttribute("async")&&!1!==t.async?this.delayedScripts.async.push(t):t.hasAttribute("defer")&&!1!==t.defer||"module"===t.getAttribute("data-rocket-type")?this.delayedScripts.defer.push(t):this.delayedScripts.normal.push(t):this.delayedScripts.normal.push(t)}))}async B(t){if(await this.G(),!0!==t.noModule||!("noModule"in HTMLScriptElement.prototype))return new Promise((e=>{let i;function o(){(i||t).setAttribute("data-rocket-status","executed"),e()}try{if(navigator.userAgent.indexOf("Firefox/")>0||""===navigator.vendor||this.CSPIssue)i=document.createElement("script"),[...t.attributes].forEach((t=>{let e=t.nodeName;"type"!==e&&("data-rocket-type"===e&&(e="type"),"data-rocket-src"===e&&(e="src"),i.setAttribute(e,t.nodeValue))})),t.text&&(i.text=t.text),i.hasAttribute("src")?(i.addEventListener("load",o),i.addEventListener("error",(function(){i.setAttribute("data-rocket-status","failed-network"),e()})),setTimeout((()=>{i.isConnected||e()}),1)):(i.text=t.text,o()),t.parentNode.replaceChild(i,t);else{const i=t.getAttribute("data-rocket-type"),s=t.getAttribute("data-rocket-src");i?(t.type=i,t.removeAttribute("data-rocket-type")):t.removeAttribute("type"),t.addEventListener("load",o),t.addEventListener("error",(i=>{this.CSPIssue&&i.target.src.startsWith("data:")?(console.log("WPRocket: data-uri blocked by CSP -> fallback"),t.removeAttribute("src"),this.B(t).then(e)):(t.setAttribute("data-rocket-status","failed-network"),e())})),s?(t.removeAttribute("data-rocket-src"),t.src=s):t.src="data:text/javascript;base64,"+window.btoa(unescape(encodeURIComponent(t.text)))}}catch(i){t.setAttribute("data-rocket-status","failed-transform"),e()}}));t.setAttribute("data-rocket-status","skipped")}async A(t){const e=t.shift();return e&&e.isConnected?(await this.B(e),this.A(t)):Promise.resolve()}q(){this.T([...this.delayedScripts.normal,...this.delayedScripts.defer,...this.delayedScripts.async],"preload")}T(t,e){var i=document.createDocumentFragment();t.forEach((t=>{const o=t.getAttribute&&t.getAttribute("data-rocket-src")||t.src;if(o&&!o.startsWith("data:")){const s=document.createElement("link");s.href=o,s.rel=e,"preconnect"!==e&&(s.as="script"),t.getAttribute&&"module"===t.getAttribute("data-rocket-type")&&(s.crossOrigin=!0),t.crossOrigin&&(s.crossOrigin=t.crossOrigin),t.integrity&&(s.integrity=t.integrity),i.appendChild(s),this.trash.push(s)}})),document.head.appendChild(i)}j(t){let e={};function i(i,o){return e[o].eventsToRewrite.indexOf(i)>=0&&!t.everythingLoaded?"rocket-"+i:i}function o(t,o){!function(t){e[t]||(e[t]={originalFunctions:{add:t.addEventListener,remove:t.removeEventListener},eventsToRewrite:[]},t.addEventListener=function(){arguments[0]=i(arguments[0],t),e[t].originalFunctions.add.apply(t,arguments)},t.removeEventListener=function(){arguments[0]=i(arguments[0],t),e[t].originalFunctions.remove.apply(t,arguments)})}(t),e[t].eventsToRewrite.push(o)}function s(e,i){let o=e[i];e[i]=null,Object.defineProperty(e,i,{get:()=>o||function(){},set(s){t.everythingLoaded?o=s:e["rocket"+i]=o=s}})}o(document,"DOMContentLoaded"),o(window,"DOMContentLoaded"),o(window,"load"),o(window,"pageshow"),o(document,"readystatechange"),s(document,"onreadystatechange"),s(window,"onload"),s(window,"onpageshow");try{Object.defineProperty(document,"readyState",{get:()=>t.rocketReadyState,set(e){t.rocketReadyState=e},configurable:!0}),document.readyState="loading"}catch(t){console.log("WPRocket DJE readyState conflict, bypassing")}}F(t){let e;function i(e){return t.everythingLoaded?e:e.split(" ").map((t=>"load"===t||0===t.indexOf("load.")?"rocket-jquery-load":t)).join(" ")}function o(o){function s(t){const e=o.fn[t];o.fn[t]=o.fn.init.prototype[t]=function(){return this[0]===window&&("string"==typeof arguments[0]||arguments[0]instanceof String?arguments[0]=i(arguments[0]):"object"==typeof arguments[0]&&Object.keys(arguments[0]).forEach((t=>{const e=arguments[0][t];delete arguments[0][t],arguments[0][i(t)]=e}))),e.apply(this,arguments),this}}o&&o.fn&&!t.allJQueries.includes(o)&&(o.fn.ready=o.fn.init.prototype.ready=function(e){return t.domReadyFired?e.bind(document)(o):document.addEventListener("rocket-DOMContentLoaded",(()=>e.bind(document)(o))),o([])},s("on"),s("one"),t.allJQueries.push(o)),e=o}o(window.jQuery),Object.defineProperty(window,"jQuery",{get:()=>e,set(t){o(t)}})}async H(t){const e=document.querySelector("script[data-webpack]");e&&(await async function(){return new Promise((t=>{e.addEventListener("load",t),e.addEventListener("error",t)}))}(),await t.K(),await t.H(t))}async U(){this.domReadyFired=!0;try{document.readyState="interactive"}catch(t){}await this.G(),document.dispatchEvent(new Event("rocket-readystatechange")),await this.G(),document.rocketonreadystatechange&&document.rocketonreadystatechange(),await this.G(),document.dispatchEvent(new Event("rocket-DOMContentLoaded")),await this.G(),window.dispatchEvent(new Event("rocket-DOMContentLoaded"))}async J(){try{document.readyState="complete"}catch(t){}await this.G(),document.dispatchEvent(new Event("rocket-readystatechange")),await this.G(),document.rocketonreadystatechange&&document.rocketonreadystatechange(),await this.G(),window.dispatchEvent(new Event("rocket-load")),await this.G(),window.rocketonload&&window.rocketonload(),await this.G(),this.allJQueries.forEach((t=>t(window).trigger("rocket-jquery-load"))),await this.G();const t=new Event("rocket-pageshow");t.persisted=this.persisted,window.dispatchEvent(t),await this.G(),window.rocketonpageshow&&window.rocketonpageshow({persisted:this.persisted}),this.windowLoaded=!0}m(){document.onreadystatechange&&document.onreadystatechange(),window.onload&&window.onload(),window.onpageshow&&window.onpageshow({persisted:this.persisted})}I(){const t=new Map;document.write=document.writeln=function(e){const i=document.currentScript;i||console.error("WPRocket unable to document.write this: "+e);const o=document.createRange(),s=i.parentElement;let n=t.get(i);void 0===n&&(n=i.nextSibling,t.set(i,n));const c=document.createDocumentFragment();o.setStart(c,0),c.appendChild(o.createContextualFragment(e)),s.insertBefore(c,n)}}async G(){Date.now()-this.lastBreath>45&&(await this.K(),this.lastBreath=Date.now())}async K(){return document.hidden?new Promise((t=>setTimeout(t))):new Promise((t=>requestAnimationFrame(t)))}N(){this.trash.forEach((t=>t.remove()))}static run(){const t=new RocketLazyLoadScripts;t.p(t)}}RocketLazyLoadScripts.run()})();</script> <meta name="viewport" content="width=device-width, initial-scale=1" /> <meta name='robots' content='index, follow, max-image-preview:large, max-snippet:-1, max-video-preview:-1' /> <style></style> <script id="Cookiebot" src="https://consent.cookiebot.com/uc.js" data-cbid="947baaab-91ba-4a51-8acd-7852908ddf48" type="text/javascript" data-rocket-defer defer></script>  <script type="rocketlazyloadscript"> var _mtm = window._mtm = window._mtm || []; _mtm.push({'mtm.startTime': (new Date().getTime()), 'event': 'mtm.Start'}); var d=document, g=d.createElement('script'), s=d.getElementsByTagName('script')[0]; g.async=true; g.src='https://matomo.vrolijkonline.com/js/container_iVTVa4U9.js'; s.parentNode.insertBefore(g,s); </script>   <script type="rocketlazyloadscript"> var _paq = window._paq = window._paq || []; /* tracker methods like "setCustomDimension" should be called before "trackPageView" */ _paq.push(['trackPageView']); _paq.push(['enableLinkTracking']); (function() { var u="//matomo.vrolijkonline.com/"; _paq.push(['setTrackerUrl', u+'matomo.php']); _paq.push(['setSiteId', '3']); var d=document, g=d.createElement('script'), s=d.getElementsByTagName('script')[0]; g.async=true; g.src=u+'matomo.js'; s.parentNode.insertBefore(g,s); })(); </script>  <meta name="google-site-verification" content="s98I9gFB17oRubDtqcn1_cdAMuQMnKDr6nzEyxivrLg" />  <link rel="canonical" href="https://symeres.com/services/admescope-adme-tox/" /> <meta property="og:locale" content="en_US" /> <meta property="og:type" content="article" /> <meta property="og:title" content="Admescope ADME-Tox - Symeres" /> <meta property="og:description" content="Introduction We can support your pharmaceutical discovery and development programs even […]" /> <meta property="og:url" content="https://symeres.com/services/admescope-adme-tox/" /> <meta property="og:site_name" content="Symeres" /> <meta property="article:modified_time" content="2024-04-12T07:11:23+00:00" /> <meta property="og:image" content="https://symeres.com/wp-content/uploads/2023/06/Hero-Image-Adme-1.jpg" /> <meta property="og:image:width" content="1920" /> <meta property="og:image:height" content="576" /> <meta property="og:image:type" content="image/jpeg" /> <meta name="twitter:card" content="summary_large_image" /> <meta name="twitter:label1" content="Est. reading time" /> <meta name="twitter:data1" content="4 minutes" /> <script type="application/ld+json" class="yoast-schema-graph">{"@context":"https://schema.org","@graph":[{"@type":"WebPage","@id":"https://symeres.com/services/admescope-adme-tox/","url":"https://symeres.com/services/admescope-adme-tox/","name":"Admescope ADME-Tox - Symeres","isPartOf":{"@id":"https://symeres.com/#website"},"primaryImageOfPage":{"@id":"https://symeres.com/services/admescope-adme-tox/#primaryimage"},"image":{"@id":"https://symeres.com/services/admescope-adme-tox/#primaryimage"},"thumbnailUrl":"https://symeres.com/wp-content/uploads/2023/06/Hero-Image-Adme-1.jpg","datePublished":"2023-04-20T14:42:13+00:00","dateModified":"2024-04-12T07:11:23+00:00","breadcrumb":{"@id":"https://symeres.com/services/admescope-adme-tox/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https://symeres.com/services/admescope-adme-tox/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https://symeres.com/services/admescope-adme-tox/#primaryimage","url":"https://symeres.com/wp-content/uploads/2023/06/Hero-Image-Adme-1.jpg","contentUrl":"https://symeres.com/wp-content/uploads/2023/06/Hero-Image-Adme-1.jpg","width":1920,"height":576},{"@type":"BreadcrumbList","@id":"https://symeres.com/services/admescope-adme-tox/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://symeres.com/"},{"@type":"ListItem","position":2,"name":"Services","item":"https://symeres.com/services/"},{"@type":"ListItem","position":3,"name":"Admescope ADME-Tox"}]},{"@type":"WebSite","@id":"https://symeres.com/#website","url":"https://symeres.com/","name":"Symeres","description":"Making Molecules Matter. Together.","publisher":{"@id":"https://symeres.com/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https://symeres.com/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https://symeres.com/#organization","name":"Symeres","url":"https://symeres.com/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https://symeres.com/#/schema/logo/image/","url":"https://symeres.com/wp-content/uploads/2022/12/symeres-logo-web.svg","contentUrl":"https://symeres.com/wp-content/uploads/2022/12/symeres-logo-web.svg","caption":"Symeres"},"image":{"@id":"https://symeres.com/#/schema/logo/image/"}}]}</script>  <title>Admescope ADME-Tox - Symeres</title><link rel="preload" data-rocket-preload as="font" href="https://use.typekit.net/af/7557c8/00000000000000003b9b3878/27/l?primer=7cdcb44be4a7db8877ffa5c0007b8dd865b3bbc383831fe2ea177f62257a9191&fvd=n2&v=3" crossorigin><link rel="preload" data-rocket-preload as="font" href="https://use.typekit.net/af/7f7817/00000000000000003b9b3879/27/l?primer=7cdcb44be4a7db8877ffa5c0007b8dd865b3bbc383831fe2ea177f62257a9191&fvd=i2&v=3" crossorigin><link rel="preload" data-rocket-preload as="font" href="https://use.typekit.net/af/ef2129/00000000000000003b9b387c/27/l?primer=7cdcb44be4a7db8877ffa5c0007b8dd865b3bbc383831fe2ea177f62257a9191&fvd=n4&v=3" crossorigin><link rel="preload" data-rocket-preload as="font" href="https://use.typekit.net/af/403911/00000000000000003b9b3880/27/l?primer=7cdcb44be4a7db8877ffa5c0007b8dd865b3bbc383831fe2ea177f62257a9191&fvd=n6&v=3" crossorigin><link rel="preload" data-rocket-preload as="font" href="https://use.typekit.net/af/28537c/00000000000000003b9b3881/27/l?primer=7cdcb44be4a7db8877ffa5c0007b8dd865b3bbc383831fe2ea177f62257a9191&fvd=i6&v=3" crossorigin><link rel="preload" data-rocket-preload as="font" href="https://symeres.com/wp-content/themes/symeres-2023/assets/fonts/Inter-Regular.ttf" crossorigin><link rel="preload" data-rocket-preload as="font" href="https://symeres.com/wp-content/themes/symeres-2023/assets/fonts/Inter-Bold.ttf" crossorigin><style id="wpr-usedcss">img:is([sizes=auto i],[sizes^="auto," i]){contain-intrinsic-size:3000px 1500px}:root :where(p.has-background){padding:1.25em 2.375em}:where(p.has-text-color:not(.has-link-color)) a{color:inherit}ul{box-sizing:border-box}:root :where(.wp-block-list.has-background){padding:1.25em 2.375em}.wp-block-spacer{clear:both}.wp-block-separator{border:none;border-top:2px solid}:root :where(.wp-block-separator.is-style-dots){height:auto;line-height:1;text-align:center}:root :where(.wp-block-separator.is-style-dots):before{color:currentColor;content:"···";font-family:serif;font-size:1.5em;letter-spacing:2em;padding-left:2em}.wp-block-separator{border:none;border-bottom:2px solid;margin-left:auto;margin-right:auto}.wp-block-separator.has-alpha-channel-opacity{opacity:1}.wp-block-separator:not(.is-style-wide):not(.is-style-dots){width:100px}.wp-block-image a{display:inline-block}.wp-block-image img{box-sizing:border-box;height:auto;max-width:100%;vertical-align:bottom}@media (prefers-reduced-motion:no-preference){.wp-block-image img.hide{visibility:hidden}.wp-block-image img.show{animation:.4s show-content-image}}.wp-block-image .alignright,.wp-block-image.alignright{display:table}.wp-block-image .alignright{float:right;margin:.5em 0 .5em 1em}.wp-block-image :where(figcaption){margin-bottom:1em;margin-top:.5em}:root :where(.wp-block-image.is-style-rounded img,.wp-block-image .is-style-rounded img){border-radius:9999px}.wp-block-image figure{margin:0}@keyframes show-content-image{0%{visibility:hidden}99%{visibility:hidden}to{visibility:visible}}:root :where(.wp-block-image figcaption){color:#555;font-size:13px;text-align:center}.wp-block-image{margin:0 0 1em}.wp-block-site-logo{box-sizing:border-box;line-height:0}.wp-block-site-logo a{display:inline-block;line-height:0}.wp-block-site-logo img{height:auto;max-width:100%}.wp-block-site-logo a,.wp-block-site-logo img{border-radius:inherit}:root :where(.wp-block-site-logo.is-style-rounded){border-radius:9999px}.wp-block-group{box-sizing:border-box}:where(.wp-block-group.wp-block-group-is-layout-constrained){position:relative}:where(.wp-block-group.has-background){padding:1.25em 2.375em}:root :where(.wp-block-template-part.has-background){margin-bottom:0;margin-top:0;padding:1.25em 2.375em}.wp-block-post-content{display:flow-root}img.emoji{display:inline!important;border:none!important;box-shadow:none!important;height:1em!important;width:1em!important;margin:0 .07em!important;vertical-align:-.1em!important;background:0 0!important;padding:0!important}:root{--wp-admin-theme-color:#007cba;--wp-admin-theme-color--rgb:0,124,186;--wp-admin-theme-color-darker-10:#006ba1;--wp-admin-theme-color-darker-10--rgb:0,107,161;--wp-admin-theme-color-darker-20:#005a87;--wp-admin-theme-color-darker-20--rgb:0,90,135;--wp-admin-border-width-focus:2px;--wp-block-synced-color:#7a00df;--wp-block-synced-color--rgb:122,0,223;--wp-bound-block-color:var(--wp-block-synced-color)}@media (min-resolution:192dpi){:root{--wp-admin-border-width-focus:1.5px}}:root{--wp--preset--font-size--normal:16px;--wp--preset--font-size--huge:42px}.screen-reader-text{border:0;clip:rect(1px,1px,1px,1px);clip-path:inset(50%);height:1px;margin:-1px;overflow:hidden;padding:0;position:absolute;width:1px;word-wrap:normal!important}.screen-reader-text:focus{background-color:#ddd;clip:auto!important;clip-path:none;color:#444;display:block;font-size:1em;height:auto;left:5px;line-height:normal;padding:15px 23px 14px;text-decoration:none;top:5px;width:auto;z-index:100000}html :where(.has-border-color){border-style:solid}html :where([style*=border-top-color]){border-top-style:solid}html :where([style*=border-right-color]){border-right-style:solid}html :where([style*=border-bottom-color]){border-bottom-style:solid}html :where([style*=border-left-color]){border-left-style:solid}html :where([style*=border-width]){border-style:solid}html :where([style*=border-top-width]){border-top-style:solid}html :where([style*=border-right-width]){border-right-style:solid}html :where([style*=border-bottom-width]){border-bottom-style:solid}html :where([style*=border-left-width]){border-left-style:solid}html :where(img[class*=wp-image-]){height:auto;max-width:100%}:where(figure){margin:0 0 1em}html :where(.is-position-sticky){--wp-admin--admin-bar--position-offset:var(--wp-admin--admin-bar--height,0px)}@media screen and (max-width:600px){html :where(.is-position-sticky){--wp-admin--admin-bar--position-offset:0px}}:root{--wp--preset--aspect-ratio--square:1;--wp--preset--aspect-ratio--4-3:4/3;--wp--preset--aspect-ratio--3-4:3/4;--wp--preset--aspect-ratio--3-2:3/2;--wp--preset--aspect-ratio--2-3:2/3;--wp--preset--aspect-ratio--16-9:16/9;--wp--preset--aspect-ratio--9-16:9/16;--wp--preset--color--black:#000000;--wp--preset--color--cyan-bluish-gray:#abb8c3;--wp--preset--color--white:#ffffff;--wp--preset--color--pale-pink:#f78da7;--wp--preset--color--vivid-red:#cf2e2e;--wp--preset--color--luminous-vivid-orange:#ff6900;--wp--preset--color--luminous-vivid-amber:#fcb900;--wp--preset--color--light-green-cyan:#7bdcb5;--wp--preset--color--vivid-green-cyan:#00d084;--wp--preset--color--pale-cyan-blue:#8ed1fc;--wp--preset--color--vivid-cyan-blue:#0693e3;--wp--preset--color--vivid-purple:#9b51e0;--wp--preset--color--symeres-primary:#923189;--wp--preset--color--symeres-secondary:#00a5c8;--wp--preset--color--symeres-font:#081f2d;--wp--preset--color--symeres-grey:#f3f4f5;--wp--preset--color--symeres-white:#FFF;--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple:linear-gradient(135deg,rgba(6, 147, 227, 1) 0%,rgb(155, 81, 224) 100%);--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan:linear-gradient(135deg,rgb(122, 220, 180) 0%,rgb(0, 208, 130) 100%);--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange:linear-gradient(135deg,rgba(252, 185, 0, 1) 0%,rgba(255, 105, 0, 1) 100%);--wp--preset--gradient--luminous-vivid-orange-to-vivid-red:linear-gradient(135deg,rgba(255, 105, 0, 1) 0%,rgb(207, 46, 46) 100%);--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray:linear-gradient(135deg,rgb(238, 238, 238) 0%,rgb(169, 184, 195) 100%);--wp--preset--gradient--cool-to-warm-spectrum:linear-gradient(135deg,rgb(74, 234, 220) 0%,rgb(151, 120, 209) 20%,rgb(207, 42, 186) 40%,rgb(238, 44, 130) 60%,rgb(251, 105, 98) 80%,rgb(254, 248, 76) 100%);--wp--preset--gradient--blush-light-purple:linear-gradient(135deg,rgb(255, 206, 236) 0%,rgb(152, 150, 240) 100%);--wp--preset--gradient--blush-bordeaux:linear-gradient(135deg,rgb(254, 205, 165) 0%,rgb(254, 45, 45) 50%,rgb(107, 0, 62) 100%);--wp--preset--gradient--luminous-dusk:linear-gradient(135deg,rgb(255, 203, 112) 0%,rgb(199, 81, 192) 50%,rgb(65, 88, 208) 100%);--wp--preset--gradient--pale-ocean:linear-gradient(135deg,rgb(255, 245, 203) 0%,rgb(182, 227, 212) 50%,rgb(51, 167, 181) 100%);--wp--preset--gradient--electric-grass:linear-gradient(135deg,rgb(202, 248, 128) 0%,rgb(113, 206, 126) 100%);--wp--preset--gradient--midnight:linear-gradient(135deg,rgb(2, 3, 129) 0%,rgb(40, 116, 252) 100%);--wp--preset--font-size--small:13px;--wp--preset--font-size--medium:20px;--wp--preset--font-size--large:36px;--wp--preset--font-size--x-large:42px;--wp--preset--font-family--gibson:canada-type-gibson,sans-serif;--wp--preset--spacing--20:0.44rem;--wp--preset--spacing--30:0.67rem;--wp--preset--spacing--40:1rem;--wp--preset--spacing--50:1.5rem;--wp--preset--spacing--60:2.25rem;--wp--preset--spacing--70:3.38rem;--wp--preset--spacing--80:5.06rem;--wp--preset--shadow--natural:6px 6px 9px rgba(0, 0, 0, .2);--wp--preset--shadow--deep:12px 12px 50px rgba(0, 0, 0, .4);--wp--preset--shadow--sharp:6px 6px 0px rgba(0, 0, 0, .2);--wp--preset--shadow--outlined:6px 6px 0px -3px rgba(255, 255, 255, 1),6px 6px rgba(0, 0, 0, 1);--wp--preset--shadow--crisp:6px 6px 0px rgba(0, 0, 0, 1)}:root{--wp--style--global--content-size:1024px;--wp--style--global--wide-size:1320px}:where(body){margin:0}.wp-site-blocks>.alignright{float:right;margin-left:2em}:where(.is-layout-flex){gap:.5em}:where(.is-layout-grid){gap:.5em}.is-layout-flow>.alignright{float:right;margin-inline-start:2em;margin-inline-end:0}.is-layout-constrained>.alignright{float:right;margin-inline-start:2em;margin-inline-end:0}.is-layout-constrained>:where(:not(.alignleft):not(.alignright):not(.alignfull)){max-width:var(--wp--style--global--content-size);margin-left:auto!important;margin-right:auto!important}body{font-family:var(--wp--preset--font-family--gibson);font-size:1rem;font-weight:200;line-height:1.6;padding-top:0;padding-right:0;padding-bottom:0;padding-left:0}a:where(:not(.wp-element-button)){text-decoration:underline}h1{font-family:var(--wp--preset--font-family--gibson);font-size:2.4rem;font-weight:600;line-height:1.6}h2{font-family:var(--wp--preset--font-family--gibson);font-size:2.1rem;font-weight:600;line-height:1.6}h3{font-family:var(--wp--preset--font-family--gibson);font-size:1.8rem;font-weight:600;line-height:1.6}h4{font-family:var(--wp--preset--font-family--gibson);font-size:1.4rem;font-weight:600;line-height:1.6}:root :where(.wp-element-button,.wp-block-button__link){background-color:#32373c;border-width:0;color:#fff;font-family:inherit;font-size:inherit;line-height:inherit;padding:calc(.667em + 2px) calc(1.333em + 2px);text-decoration:none}.has-medium-font-size{font-size:var(--wp--preset--font-size--medium)!important}.skip-link.screen-reader-text{border:0;clip:rect(1px,1px,1px,1px);clip-path:inset(50%);height:1px;margin:-1px;overflow:hidden;padding:0;position:absolute!important;width:1px;word-wrap:normal!important}.skip-link.screen-reader-text:focus{background-color:#eee;clip:auto!important;clip-path:none;color:#444;display:block;font-size:1em;height:auto;left:5px;line-height:normal;padding:15px 23px 14px;text-decoration:none;top:5px;width:auto;z-index:100000}@font-face{font-family:canada-type-gibson;src:url("https://use.typekit.net/af/7557c8/00000000000000003b9b3878/27/l?primer=7cdcb44be4a7db8877ffa5c0007b8dd865b3bbc383831fe2ea177f62257a9191&fvd=n2&v=3") format("woff2"),url("https://use.typekit.net/af/7557c8/00000000000000003b9b3878/27/d?primer=7cdcb44be4a7db8877ffa5c0007b8dd865b3bbc383831fe2ea177f62257a9191&fvd=n2&v=3") format("woff"),url("https://use.typekit.net/af/7557c8/00000000000000003b9b3878/27/a?primer=7cdcb44be4a7db8877ffa5c0007b8dd865b3bbc383831fe2ea177f62257a9191&fvd=n2&v=3") format("opentype");font-display:swap;font-style:normal;font-weight:200;font-stretch:normal}@font-face{font-family:canada-type-gibson;src:url("https://use.typekit.net/af/7f7817/00000000000000003b9b3879/27/l?primer=7cdcb44be4a7db8877ffa5c0007b8dd865b3bbc383831fe2ea177f62257a9191&fvd=i2&v=3") format("woff2"),url("https://use.typekit.net/af/7f7817/00000000000000003b9b3879/27/d?primer=7cdcb44be4a7db8877ffa5c0007b8dd865b3bbc383831fe2ea177f62257a9191&fvd=i2&v=3") format("woff"),url("https://use.typekit.net/af/7f7817/00000000000000003b9b3879/27/a?primer=7cdcb44be4a7db8877ffa5c0007b8dd865b3bbc383831fe2ea177f62257a9191&fvd=i2&v=3") format("opentype");font-display:swap;font-style:italic;font-weight:200;font-stretch:normal}@font-face{font-family:canada-type-gibson;src:url("https://use.typekit.net/af/ef2129/00000000000000003b9b387c/27/l?primer=7cdcb44be4a7db8877ffa5c0007b8dd865b3bbc383831fe2ea177f62257a9191&fvd=n4&v=3") format("woff2"),url("https://use.typekit.net/af/ef2129/00000000000000003b9b387c/27/d?primer=7cdcb44be4a7db8877ffa5c0007b8dd865b3bbc383831fe2ea177f62257a9191&fvd=n4&v=3") format("woff"),url("https://use.typekit.net/af/ef2129/00000000000000003b9b387c/27/a?primer=7cdcb44be4a7db8877ffa5c0007b8dd865b3bbc383831fe2ea177f62257a9191&fvd=n4&v=3") format("opentype");font-display:swap;font-style:normal;font-weight:400;font-stretch:normal}@font-face{font-family:canada-type-gibson;src:url("https://use.typekit.net/af/403911/00000000000000003b9b3880/27/l?primer=7cdcb44be4a7db8877ffa5c0007b8dd865b3bbc383831fe2ea177f62257a9191&fvd=n6&v=3") format("woff2"),url("https://use.typekit.net/af/403911/00000000000000003b9b3880/27/d?primer=7cdcb44be4a7db8877ffa5c0007b8dd865b3bbc383831fe2ea177f62257a9191&fvd=n6&v=3") format("woff"),url("https://use.typekit.net/af/403911/00000000000000003b9b3880/27/a?primer=7cdcb44be4a7db8877ffa5c0007b8dd865b3bbc383831fe2ea177f62257a9191&fvd=n6&v=3") format("opentype");font-display:swap;font-style:normal;font-weight:600;font-stretch:normal}@font-face{font-family:canada-type-gibson;src:url("https://use.typekit.net/af/28537c/00000000000000003b9b3881/27/l?primer=7cdcb44be4a7db8877ffa5c0007b8dd865b3bbc383831fe2ea177f62257a9191&fvd=i6&v=3") format("woff2"),url("https://use.typekit.net/af/28537c/00000000000000003b9b3881/27/d?primer=7cdcb44be4a7db8877ffa5c0007b8dd865b3bbc383831fe2ea177f62257a9191&fvd=i6&v=3") format("woff"),url("https://use.typekit.net/af/28537c/00000000000000003b9b3881/27/a?primer=7cdcb44be4a7db8877ffa5c0007b8dd865b3bbc383831fe2ea177f62257a9191&fvd=i6&v=3") format("opentype");font-display:swap;font-style:italic;font-weight:600;font-stretch:normal}#mega-menu-wrap-max_mega_menu_1,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 a.mega-menu-link,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-column,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-row,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 ul.mega-sub-menu{transition:none;border-radius:0;box-shadow:none;background:0 0;border:0;bottom:auto;box-sizing:border-box;clip:auto;color:#666;display:block;float:none;font-family:inherit;font-size:18px;height:auto;left:auto;line-height:1.7;list-style-type:none;margin:0;min-height:auto;max-height:none;min-width:auto;max-width:none;opacity:1;outline:0;overflow:visible;padding:0;position:relative;pointer-events:auto;right:auto;text-align:left;text-decoration:none;text-indent:0;text-transform:none;transform:none;top:auto;vertical-align:baseline;visibility:inherit;width:auto;word-wrap:break-word;white-space:normal}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 a.mega-menu-link:after,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 a.mega-menu-link:before,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-column:after,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-column:before,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item:after,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item:before,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-row:after,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-row:before,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 ul.mega-sub-menu:after,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 ul.mega-sub-menu:before,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1:after,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1:before,#mega-menu-wrap-max_mega_menu_1:after,#mega-menu-wrap-max_mega_menu_1:before{display:none}#mega-menu-wrap-max_mega_menu_1{border-radius:0}#mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation #mega-menu-max_mega_menu_1 a:focus,#mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation #mega-menu-max_mega_menu_1 input:focus,#mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation #mega-menu-max_mega_menu_1 li.mega-menu-item a.mega-menu-link:focus,#mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation #mega-menu-max_mega_menu_1 span:focus,#mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation .mega-menu-toggle:focus,#mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation .mega-toggle-block .mega-search input[type=text]:focus,#mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation .mega-toggle-block a:focus,#mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation .mega-toggle-block button.mega-toggle-animated:focus,#mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation .mega-toggle-block:focus{outline-style:solid;outline-width:3px;outline-color:#109cde;outline-offset:-3px}#mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation .mega-toggle-block button.mega-toggle-animated:focus{outline-offset:2px}#mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation>li.mega-menu-item>a.mega-menu-link:focus{background:rgba(0,0,0,0);color:#081f2d;font-weight:400;text-decoration:none;border-color:transparent}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1{text-align:left;padding:0}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 a.mega-menu-link{cursor:pointer;display:inline;transition:background .2s linear,color .2s linear,border .2s linear}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-animating>ul.mega-sub-menu{pointer-events:none}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 p{margin-bottom:10px}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 img,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 input{max-width:100%}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item>ul.mega-sub-menu{display:block;visibility:hidden;opacity:1;pointer-events:auto}@media only screen and (max-width:1230px){#mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation>li.mega-menu-item>a.mega-menu-link:focus{color:#fff;background:#222}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item>ul.mega-sub-menu{display:none;visibility:visible;opacity:1}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-toggle-on>ul.mega-sub-menu,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu.mega-menu-item.mega-toggle-on ul.mega-sub-menu{display:block}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-hide-sub-menu-on-mobile>ul.mega-sub-menu,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu.mega-menu-item.mega-toggle-on li.mega-hide-sub-menu-on-mobile>ul.mega-sub-menu{display:none}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-menu-megamenu ul.mega-sub-menu li.mega-collapse-children>ul.mega-sub-menu{display:none}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-menu-megamenu ul.mega-sub-menu li.mega-collapse-children.mega-toggle-on>ul.mega-sub-menu{display:block}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-toggle-on>ul.mega-sub-menu,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1.mega-no-js li.mega-menu-item:focus>ul.mega-sub-menu,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1.mega-no-js li.mega-menu-item:hover>ul.mega-sub-menu{visibility:visible}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-menu-megamenu ul.mega-sub-menu ul.mega-sub-menu{visibility:inherit;opacity:1;display:block}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item a[class^=dashicons]:before{font-family:dashicons}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item a.mega-menu-link:before{display:inline-block;font:inherit;font-family:dashicons;position:static;margin:0 6px 0 0;vertical-align:top;-webkit-font-smoothing:antialiased;-moz-osx-font-smoothing:grayscale;color:inherit;background:0 0;height:auto;width:auto;top:auto}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-align-bottom-left.mega-toggle-on>a.mega-menu-link{border-radius:0}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-item{margin:0 1rem 0 0;display:inline-block;height:auto;vertical-align:middle}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-item.mega-toggle-on>a.mega-menu-link{background:rgba(0,0,0,0);color:#081f2d;font-weight:400;text-decoration:none;border-color:transparent}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-item>a.mega-menu-link{line-height:40px;height:40px;padding:0;vertical-align:baseline;width:auto;display:block;color:#081f2d;text-transform:none;text-decoration:none;text-align:left;background:rgba(0,0,0,0);border:0;border-radius:0;font-family:inherit;font-size:18px;font-weight:400;outline:0}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu>ul.mega-sub-menu>li.mega-menu-row{width:100%;float:left}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu>ul.mega-sub-menu>li.mega-menu-row .mega-menu-column{float:left;min-height:1px}@media only screen and (min-width:1231px){#mega-menu-wrap-max_mega_menu_1{background:rgba(0,0,0,0)}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect=fade_up] li.mega-menu-item.mega-menu-flyout ul.mega-sub-menu,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect=fade_up] li.mega-menu-item.mega-menu-megamenu>ul.mega-sub-menu{opacity:0;transform:translate(0,10px);transition:opacity .2s ease-in,transform .2s ease-in,visibility .2s ease-in}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect=fade_up] li.mega-menu-item.mega-menu-megamenu.mega-toggle-on ul.mega-sub-menu,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect=fade_up] li.mega-menu-item.mega-toggle-on>ul.mega-sub-menu,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect=fade_up].mega-no-js li.mega-menu-item:focus>ul.mega-sub-menu,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect=fade_up].mega-no-js li.mega-menu-item:hover>ul.mega-sub-menu{opacity:1;transform:translate(0,0)}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-megamenu.mega-menu-item{position:static}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-item>a.mega-menu-link:focus,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-item>a.mega-menu-link:hover{background:rgba(0,0,0,0);color:#081f2d;font-weight:400;text-decoration:none;border-color:transparent}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu>ul.mega-sub-menu>li.mega-menu-row>ul.mega-sub-menu>li.mega-menu-columns-3-of-12{width:25%}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-megamenu>ul.mega-sub-menu li.mega-menu-columns-3-of-12{width:25%}}@media only screen and (max-width:1230px){#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-item.mega-toggle-on>a.mega-menu-link{color:#fff;background:#222}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-item{display:list-item;margin:0;clear:both;border:0}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-item>a.mega-menu-link{border-radius:0;border:0;margin:0;line-height:40px;height:40px;padding:0 10px;background:0 0;text-align:left;color:#fff;font-size:18px}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu>ul.mega-sub-menu>li.mega-menu-row>ul.mega-sub-menu>li.mega-menu-column{width:100%;clear:both}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu>ul.mega-sub-menu>li.mega-menu-row .mega-menu-column>ul.mega-sub-menu>li.mega-menu-item{padding:0 15px 15px;width:100%}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-megamenu>ul.mega-sub-menu{z-index:999;border-radius:0;background:rgba(0,0,0,0);border:0;padding:0;position:absolute;width:100%;max-width:none;left:0}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-megamenu>ul.mega-sub-menu>li.mega-menu-item ul.mega-sub-menu{clear:both}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-megamenu>ul.mega-sub-menu>li.mega-menu-item ul.mega-sub-menu li.mega-menu-item ul.mega-sub-menu{margin-left:10px}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-megamenu>ul.mega-sub-menu li.mega-menu-column>ul.mega-sub-menu ul.mega-sub-menu ul.mega-sub-menu{margin-left:10px}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-megamenu>ul.mega-sub-menu li.mega-menu-column>ul.mega-sub-menu>li.mega-menu-item,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-megamenu>ul.mega-sub-menu>li.mega-menu-item{color:#666;font-family:inherit;font-size:18px;display:block;float:left;clear:none;padding:0 15px 15px;vertical-align:top}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-megamenu>ul.mega-sub-menu li.mega-menu-column>ul.mega-sub-menu>li.mega-menu-item.mega-menu-clear,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-megamenu>ul.mega-sub-menu>li.mega-menu-item.mega-menu-clear{clear:left}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-megamenu>ul.mega-sub-menu li.mega-menu-column>ul.mega-sub-menu>li.mega-menu-item>a.mega-menu-link,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-megamenu>ul.mega-sub-menu>li.mega-menu-item>a.mega-menu-link{color:#00a5c8;font-family:inherit;font-size:18px;text-transform:none;text-decoration:none;font-weight:400;text-align:left;margin:0;padding:0;vertical-align:top;display:block;border-top:0 solid #00a5c8;border-left:0 solid #00a5c8;border-right:0px solid #00a5c8;border-bottom:2px solid #00a5c8}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-megamenu>ul.mega-sub-menu li.mega-menu-column>ul.mega-sub-menu>li.mega-menu-item>a.mega-menu-link:hover,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-megamenu>ul.mega-sub-menu>li.mega-menu-item>a.mega-menu-link:hover{border-color:#00a5c8}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-megamenu>ul.mega-sub-menu li.mega-menu-column>ul.mega-sub-menu>li.mega-menu-item>a.mega-menu-link:focus,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-megamenu>ul.mega-sub-menu li.mega-menu-column>ul.mega-sub-menu>li.mega-menu-item>a.mega-menu-link:hover,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-megamenu>ul.mega-sub-menu>li.mega-menu-item>a.mega-menu-link:focus,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-megamenu>ul.mega-sub-menu>li.mega-menu-item>a.mega-menu-link:hover{color:#00a5c8;font-weight:400;text-decoration:none;background:rgba(0,0,0,0)}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-megamenu>ul.mega-sub-menu li.mega-menu-column>ul.mega-sub-menu>li.mega-menu-item li.mega-menu-item>a.mega-menu-link,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-megamenu>ul.mega-sub-menu>li.mega-menu-item li.mega-menu-item>a.mega-menu-link{color:#fff;font-family:inherit;font-size:18px;text-transform:none;text-decoration:none;font-weight:400;text-align:left;margin:0;padding:0;vertical-align:top;display:block;border:0}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-megamenu>ul.mega-sub-menu li.mega-menu-column>ul.mega-sub-menu>li.mega-menu-item li.mega-menu-item>a.mega-menu-link:hover,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-megamenu>ul.mega-sub-menu>li.mega-menu-item li.mega-menu-item>a.mega-menu-link:hover{border-color:transparent}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-megamenu>ul.mega-sub-menu li.mega-menu-column>ul.mega-sub-menu>li.mega-menu-item li.mega-menu-item>a.mega-menu-link:focus,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-megamenu>ul.mega-sub-menu li.mega-menu-column>ul.mega-sub-menu>li.mega-menu-item li.mega-menu-item>a.mega-menu-link:hover,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-megamenu>ul.mega-sub-menu>li.mega-menu-item li.mega-menu-item>a.mega-menu-link:focus,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-megamenu>ul.mega-sub-menu>li.mega-menu-item li.mega-menu-item>a.mega-menu-link:hover{color:#fff;font-weight:400;text-decoration:none;background:rgba(0,0,0,0)}@media only screen and (max-width:1230px){#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-megamenu>ul.mega-sub-menu{float:left;position:static;width:100%}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-megamenu>ul.mega-sub-menu{border:0;padding:10px;border-radius:0}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-megamenu>ul.mega-sub-menu>li.mega-menu-item{width:100%;clear:both}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-flyout ul.mega-sub-menu{z-index:999;position:absolute;width:300px;max-width:none;padding:20px;border:0;background:rgba(0,0,0,0);border-radius:0}@media only screen and (max-width:1230px){#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-flyout ul.mega-sub-menu{float:left;position:static;width:100%;padding:0;border:0;border-radius:0}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item{clear:both}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item:first-child>a.mega-menu-link{border-top-left-radius:0;border-top-right-radius:0}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item a.mega-menu-link{display:block;background:rgba(0,0,0,0);color:#fff;font-family:inherit;font-size:18px;font-weight:400;padding:0;line-height:35px;text-decoration:none;text-transform:none;vertical-align:baseline}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item:first-child>a.mega-menu-link{border-top-left-radius:0;border-top-right-radius:0}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item:last-child>a.mega-menu-link{border-bottom-right-radius:0;border-bottom-left-radius:0}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item a.mega-menu-link:focus,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item a.mega-menu-link:hover{background:rgba(0,0,0,0);font-weight:400;text-decoration:none;color:#fff}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item ul.mega-sub-menu{position:absolute;left:100%;top:0}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item-has-children>a.mega-menu-link>span.mega-indicator{display:inline-block;width:auto;background:0 0;position:relative;pointer-events:auto;left:auto;min-width:auto;font-size:inherit;padding:0;margin:0 0 0 6px;height:auto;line-height:inherit;color:inherit}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item-has-children>a.mega-menu-link>span.mega-indicator:after{content:"";font-family:dashicons;font-weight:400;display:inline-block;margin:0;vertical-align:top;-webkit-font-smoothing:antialiased;-moz-osx-font-smoothing:grayscale;transform:rotate(0);color:inherit;position:relative;background:0 0;height:auto;width:auto;right:auto;line-height:inherit}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item-has-children li.mega-menu-item-has-children>a.mega-menu-link>span.mega-indicator{float:right}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item-has-children.mega-collapse-children.mega-toggle-on>a.mega-menu-link>span.mega-indicator:after{content:""}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu:not(.mega-menu-tabbed) li.mega-menu-item-has-children:not(.mega-collapse-children)>a.mega-menu-link>span.mega-indicator{display:none}@media only screen and (min-width:1231px){#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-flyout li.mega-menu-item a.mega-menu-link>span.mega-indicator:after{content:""}}@media only screen and (max-width:1230px){#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item:last-child>a.mega-menu-link{border-bottom-right-radius:0;border-bottom-left-radius:0}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item ul.mega-sub-menu{position:static;left:0;width:100%}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item ul.mega-sub-menu a.mega-menu-link{padding-left:20px}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item ul.mega-sub-menu ul.mega-sub-menu a.mega-menu-link{padding-left:30px}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item-has-children>a.mega-menu-link>span.mega-indicator{float:right}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item-has-children.mega-toggle-on>a.mega-menu-link>span.mega-indicator:after{content:""}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item-has-children.mega-hide-sub-menu-on-mobile>a.mega-menu-link>span.mega-indicator{display:none}#mega-menu-wrap-max_mega_menu_1:after{content:"";display:table;clear:both}}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle{display:none;z-index:1;cursor:pointer;background:rgba(255,255,255,.1);border-radius:2px 2px 2px 2px;line-height:80px;height:80px;text-align:left;user-select:none;-webkit-tap-highlight-color:transparent;outline:0;white-space:nowrap}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle img{max-width:100%;padding:0}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-blocks-center,#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-blocks-left,#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-blocks-right{display:-webkit-box;display:-ms-flexbox;display:-webkit-flex;display:flex;-ms-flex-preferred-size:33.33%;-webkit-flex-basis:33.33%;flex-basis:33.33%}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-blocks-left{-webkit-box-flex:1;-ms-flex:1;-webkit-flex:1;flex:1;-webkit-box-pack:start;-ms-flex-pack:start;-webkit-justify-content:flex-start;justify-content:flex-start}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-blocks-left .mega-toggle-block{margin-left:6px}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-blocks-left .mega-toggle-block:only-child{margin-right:6px}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-blocks-center{-webkit-box-pack:center;-ms-flex-pack:center;-webkit-justify-content:center;justify-content:center}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-blocks-center .mega-toggle-block{margin-left:3px;margin-right:3px}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-blocks-right{-webkit-box-flex:1;-ms-flex:1;-webkit-flex:1;flex:1;-webkit-box-pack:end;-ms-flex-pack:end;-webkit-justify-content:flex-end;justify-content:flex-end}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-blocks-right .mega-toggle-block{margin-right:6px}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-blocks-right .mega-toggle-block:only-child{margin-left:6px}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block{display:-webkit-box;display:-ms-flexbox;display:-webkit-flex;display:flex;height:100%;outline:0;-webkit-align-self:center;-ms-flex-item-align:center;align-self:center;-ms-flex-negative:0;-webkit-flex-shrink:0;flex-shrink:0}@media only screen and (max-width:1230px){#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle{display:-webkit-box;display:-ms-flexbox;display:-webkit-flex;display:flex}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle+#mega-menu-max_mega_menu_1{background:#222;padding:1rem;display:none;position:absolute;width:100%;z-index:9999999}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle.mega-menu-open+#mega-menu-max_mega_menu_1{display:block}}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-0{cursor:pointer}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-0 .mega-toggle-animated{padding:0;display:-webkit-box;display:-ms-flexbox;display:-webkit-flex;display:flex;cursor:pointer;transition-property:opacity,filter;transition-duration:.15s;transition-timing-function:linear;font:inherit;color:inherit;text-transform:none;background-color:transparent;border:0;margin:0;overflow:visible;transform:scale(.8);align-self:center;outline:0;background:0 0}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-0 .mega-toggle-animated-box{width:40px;height:24px;display:inline-block;position:relative;outline:0}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-0 .mega-toggle-animated-inner{display:block;top:50%;margin-top:-2px}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-0 .mega-toggle-animated-inner,#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-0 .mega-toggle-animated-inner::after,#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-0 .mega-toggle-animated-inner::before{width:40px;height:4px;background-color:#ddd;border-radius:4px;position:absolute;transition-property:transform;transition-duration:.15s;transition-timing-function:ease}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-0 .mega-toggle-animated-inner::after,#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-0 .mega-toggle-animated-inner::before{content:"";display:block}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-0 .mega-toggle-animated-inner::before{top:-10px}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-0 .mega-toggle-animated-inner::after{bottom:-10px}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-0 .mega-toggle-animated-slider .mega-toggle-animated-inner{top:2px}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-0 .mega-toggle-animated-slider .mega-toggle-animated-inner::before{top:10px;transition-property:transform,opacity;transition-timing-function:ease;transition-duration:.15s}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-0 .mega-toggle-animated-slider .mega-toggle-animated-inner::after{top:20px}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle.mega-menu-open .mega-toggle-block-0 .mega-toggle-animated-slider .mega-toggle-animated-inner{transform:translate3d(0,10px,0) rotate(45deg)}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle.mega-menu-open .mega-toggle-block-0 .mega-toggle-animated-slider .mega-toggle-animated-inner::before{transform:rotate(-45deg) translate3d(-5.71429px,-6px,0);opacity:0}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle.mega-menu-open .mega-toggle-block-0 .mega-toggle-animated-slider .mega-toggle-animated-inner::after{transform:translate3d(0,-20px,0) rotate(-90deg)}#mega-menu-wrap-max_mega_menu_1{clear:both}@font-face{font-display:swap;font-family:dashicons;src:url("https://symeres.com/wp-includes/fonts/dashicons.eot?99ac726223c749443b642ce33df8b800");src:url("https://symeres.com/wp-includes/fonts/dashicons.eot?99ac726223c749443b642ce33df8b800#iefix") format("embedded-opentype"),url("data:application/x-font-woff;charset=utf-8;base64,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") format("woff"),url("https://symeres.com/wp-includes/fonts/dashicons.ttf?99ac726223c749443b642ce33df8b800") format("truetype");font-weight:400;font-style:normal}p,ul{font-family:canada-type-gibson}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item a.mega-menu-link,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-item>a.mega-menu-link,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-megamenu>ul.mega-sub-menu li.mega-menu-column>ul.mega-sub-menu>li.mega-menu-item li.mega-menu-item>a.mega-menu-link,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-megamenu>ul.mega-sub-menu li.mega-menu-column>ul.mega-sub-menu>li.mega-menu-item>a.mega-menu-link,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-megamenu>ul.mega-sub-menu>li.mega-menu-item li.mega-menu-item>a.mega-menu-link,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1>li.mega-menu-megamenu>ul.mega-sub-menu>li.mega-menu-item>a.mega-menu-link{font-family:canada-type-gibson}@media only screen and (min-width:772px){#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect=fade_up] li.mega-menu-item.mega-menu-flyout ul.mega-sub-menu,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect=fade_up] li.mega-menu-item.mega-menu-megamenu>ul.mega-sub-menu{height:calc(100vh - 75px);overflow-y:hidden}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect=fade_up] li.mega-menu-item.mega-menu-flyout ul.mega-sub-menu{height:calc(100vh - 107px);max-height:fit-content}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-menu-megamenu ul.mega-sub-menu ul.mega-sub-menu,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu>ul.mega-sub-menu>li.mega-menu-row,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu>ul.mega-sub-menu>li.mega-menu-row .mega-menu-column>ul.mega-sub-menu>li.mega-menu-item,#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu>ul.mega-sub-menu>li.mega-menu-row>ul.mega-sub-menu>li.mega-menu-columns-3-of-12{height:100%}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu>ul.mega-sub-menu>li.mega-menu-row>ul.mega-sub-menu>li.mega-menu-columns-3-of-12 li ul{overflow-y:scroll;padding-bottom:20px!important;-ms-overflow-style:none;scrollbar-width:none}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu>ul.mega-sub-menu>li.mega-menu-row>ul.mega-sub-menu>li.mega-menu-columns-3-of-12 li ul::-webkit-scrollbar{display:none}}.downloads__files>div{height:auto!important;margin-bottom:10px!important}.downloads__files h3{margin-bottom:10px!important}.downloads__files #remove-all-files{margin-top:0!important}.downloads__aside .form__col label{display:none}.downloads__aside{top:55%!important;transform:translateY(-50%)!important}@media only screen and (max-width:567px){.downloads__content{inset:0!important;width:100vw!important;height:80vh!important;top:unset!important;right:0!important;bottom:0!important}.downloads__aside{right:0!important;top:10rem!important;transform:none!important}}:root,h1,h2,h3,h4{font-family:canada-type-gibson,sans-serif}.ez-toc-section,.main a{scroll-margin-top:6rem}.hidden{position:absolute;overflow:hidden;height:1px;width:1px;clip:rect(1px,1px,1px,1px);white-space:nowrap;word-wrap:normal}.wp-site-blocks{width:100%;min-height:100vh;display:flex;flex-direction:column}.main,body{display:flex}*{box-sizing:border-box}html{scroll-behavior:smooth}body{flex-direction:column;min-height:100vh;margin:0;align-items:center;overflow-y:scroll;overflow-x:hidden}.main{width:100%;flex:1;flex-direction:column;align-items:center}.main--page{background-image:var(--wpr-bg-026c42f8-915a-4ddb-96e4-06800b8fc426);background-position:top center;background-repeat:no-repeat;margin-top:2rem}.main__content{flex:1;width:100%;max-width:var(--wp--style--global--content-size);position:relative;padding:0 1rem}.main__content .entry-content{padding-right:212px}.main__content .entry-content>.block{width:100vw;position:relative;left:calc(50% + 106px);right:50%;margin-left:-50vw;margin-right:-50vw;margin-bottom:1.6rem}.main h1,.main h2,.main h3{border-bottom:4px solid currentColor;padding-bottom:.35em;margin:1.6rem 0 1rem;color:var(--wp--preset--color--symeres-primary)}.svgsprite{width:0;height:0;line-height:0;display:inherit}.main h1,.main h2,.main h3{display:inline-block}.search__button:hover,.search__qry,.search__qry:focus+.search__button{transition-duration:.4s}:root{--wp--preset--color--symeres-primary:#923189;--wp--preset--color--symeres-secondary:#00a5c8;--wp--preset--color--symeres-font:#081f2d;--wp--preset--color--symeres-dgrey:#EBEBEB;--wp--preset--color--symeres-grey:#f3f4f5;--wp--preset--color--symeres-white:#FFF;--wp--preset--font-size--small:13px;--wp--preset--font-size--medium:20px;--wp--preset--font-size--large:36px;--wp--preset--font-size--x-large:42px;--wp--preset--font-family--gibson:"Gibson",serif;--wp--style--global--content-size:1024px;--wp--style--global--wide-size:1320px;font-size:16px;font-weight:200!important;line-height:1.4}h1,h2,h3,h4{font-weight:600!important;line-height:1.1}.main h1{font-size:45px;font-size:2.8125rem}.main h2{font-size:30px;font-size:1.875rem}.main h3{font-size:24px;font-size:1.5rem}.main h4{font-size:21px;font-size:1.3125rem;margin:1.6rem 0 .5rem}.main a{color:var(--wp--preset--color--symeres-primary);text-decoration:underline}#ez-toc-container a,.footer__block a,.main a:focus,.main a:hover{text-decoration:none}.main figure{margin:0;line-height:0}.main strong{font-weight:600}.main__content p strong,.main__content strong{font-family:canada-type-gibson,sans-serif;font-weight:600!important}.main hr{width:100%!important;border-bottom:1px solid rgba(0,0,0,.25);margin:.75rem 0 1.6rem}.main table{width:100%}.main__content{padding-bottom:2rem}.main__content p{margin:1.6rem 0 .5rem}.main__content ul{margin:1.6rem 0 .5rem;padding:0 0 0 1.1em}.footer__content{font-family:canada-type-gibson,sans-serif;font-weight:200!important}.main__content h1+p,.main__content h2+p,.main__content h3+p,.main__content h4+p{margin-top:0}.main__content figure{margin:1.6rem 0 .5rem}.main__content .is-layout-constrained>.alignright{float:right;margin-inline-end:0;margin-inline-start:2em}@media only screen and (max-width :1229px){.entry-content{padding-right:0!important}.main p,.main ul{font-size:15px;font-size:.9375rem;margin-bottom:1.1rem}.main h1,.main h2{font-size:30px;font-size:1.875rem}.main h3{font-size:18px;font-size:1.125rem}.main h4{font-size:15px;font-size:.9375rem}}.header{background-color:var(--wp--preset--color--symeres-white);border-bottom:1px solid var(--wp--preset--color--symeres-font);display:flex;justify-content:center;width:100%;position:sticky;top:0;z-index:11}.header__content{width:100%;max-width:var(--wp--style--global--wide-size);display:flex;justify-content:space-between;align-items:center;padding:.65rem 0 0;margin:0 1rem}.header__logo{width:240px;height:auto;margin-bottom:.65rem}.header__logo img{max-height:54px}li.header__button>a.mega-menu-link{background-color:var(--wp--preset--color--symeres-primary)!important;color:var(--wp--preset--color--symeres-white)!important;padding:.25rem .5rem!important;line-height:1!important;display:flex!important;align-items:center;height:30px!important}.header__search{margin-left:.75rem;display:flex}.header__search button{appearance:none;background-color:transparent;border:0}.header__search svg{width:26px;height:26px;color:var(--wp--preset--color--symeres-primary)}@media only screen and (max-width :1229px){.header__logo{width:154px}.header__content{min-height:80px}.header__search{display:none}}.search{position:relative}.search__button{display:inline-flex;cursor:pointer;font-size:1rem;line-height:1;width:100%;margin:0;padding:.5rem}.search__qry{position:absolute;background-color:var(--wp--preset--color--symeres-white);outline:0;border:0;border-radius:3px;font-size:21px;font-size:1.3125rem;width:0;height:100%;z-index:10;right:2.5rem;padding:0}.search__qry:focus{width:363px;padding:.5rem;border:1px solid var(--wp--preset--color--symeres-font)}@media only screen and (min-width :1230px) and (max-width:1599999984px){.mega-menu,.mega-menu-item,.mega-menu-wrap{position:static!important}.mega-menu-flyout .mega-sub-menu,.mega-menu-grid .mega-sub-menu{background:var(--wp--preset--color--symeres-font)!important;top:100%!important;pointer-events:none!important;display:flex!important}.mega-indicator{color:var(--wp--preset--color--symeres-secondary)!important}.mega-menu-grid .mega-sub-menu{width:100%!important;position:absolute!important;z-index:999!important;left:0!important;justify-content:center!important}.mega-menu-flyout .mega-sub-menu{justify-content:center!important;flex-wrap:wrap!important}.mega-menu-flyout .mega-sub-menu>*{flex:0 0 100%!important}.mega-menu>.mega-toggle-on>.mega-menu-link{position:relative!important}.mega-menu>.mega-toggle-on>.mega-menu-link:before{content:""!important;background-color:var(--wp--preset--color--symeres-font)!important;clip-path:url(#hexagon)!important;width:50px!important;height:50px!important;position:absolute!important;top:110%!important;left:50%!important;margin-left:-25px!important}.mega-menu-row{max-width:var(--wp--style--global--wide-size)!important}.mega-menu-row .mega-sub-menu{position:static!important;background:0 0!important;display:block!important;padding:.5rem 0 0 20px!important}.mega-menu-row .mega-sub-menu .mega-menu-column .mega-sub-menu .mega-sub-menu .mega-menu-item{margin-bottom:.25rem!important}.mega-menu-row .mega-sub-menu .mega-menu-column .mega-sub-menu .mega-sub-menu .mega-menu-item .mega-menu-link{position:relative!important}.mega-menu-row .mega-sub-menu .mega-menu-column .mega-sub-menu .mega-sub-menu .mega-menu-item .mega-menu-link:before{content:""!important;position:absolute!important;top:7px!important;left:-22px!important;display:block!important;width:14px!important;height:14px!important;background-image:var(--wpr-bg-3ae9b33c-5882-493a-b626-cdf397e1a8a2)!important;background-repeat:no-repeat!important;background-position:center!important;background-size:cover!important}}.footer__block a,.footer__bottom,.footer__top{color:var(--wp--preset--color--symeres-white)}.footer{width:100%}.footer__bottom,.footer__top{padding:0 1rem;display:flex;flex-direction:column;align-items:center}.footer__top{background-color:var(--wp--preset--color--symeres-secondary)}.footer__bottom{background-color:var(--wp--preset--color--symeres-primary)}.footer__content{width:100%;max-width:var(--wp--style--global--wide-size);display:grid;grid-template-columns:1fr 1fr 1fr 2fr;gap:1rem;padding:2rem 0}.footer__content--logo{padding:1.75rem 0;border-bottom:3px solid var(--wp--preset--color--symeres-white)}.footer__content--bottom{grid-template-columns:1fr;text-align:center;padding:.5rem 0}.footer__content--bottom p{margin:0;font-size:14px;font-size:.875rem}.footer__logo figure{margin:0;max-width:236px}.footer__block h4{font-size:18px;font-size:1.125rem;line-height:1.6;margin:0}.footer__block ul{margin:0;padding:0;list-style:none;font-size:18px;font-size:1.125rem;line-height:1.6}.footer__block--social{margin-left:10rem;text-align:right;display:flex;flex-wrap:wrap;justify-content:flex-end}.footer__block--social svg{width:36px;height:36px}.footer__block--social ul{display:flex}.footer__block--social ul li{margin-left:.25rem}@media only screen and (max-width :1229px){.max-mega-menu{top:80px!important;height:calc(100svh - 80px)!important;overflow-y:auto!important}.mega-menu-toggle.mega-menu-open{min-height:calc(80px - 1rem)!important}.mega-menu-flyout .mega-sub-menu,.mega-menu-grid .mega-sub-menu{display:none!important;position:static!important;padding:0!important}.mega-menu-flyout .mega-sub-menu.mega-toggle-on,.mega-menu-flyout.mega-toggle-on .mega-sub-menu,.mega-menu-grid .mega-sub-menu.mega-toggle-on,.mega-menu-grid.mega-toggle-on .mega-sub-menu{display:block!important}.mega-menu-flyout .mega-sub-menu .mega-menu-column,.mega-menu-grid .mega-sub-menu .mega-menu-column{margin-bottom:1rem!important}.mega-menu-flyout .mega-sub-menu .mega-menu-item,.mega-menu-grid .mega-sub-menu .mega-menu-item{padding:0 .5rem 1rem!important}.mega-menu-flyout .mega-sub-menu .mega-menu-item .mega-menu-item,.mega-menu-grid .mega-sub-menu .mega-menu-item .mega-menu-item{padding:.5rem 0 0!important}.mega-menu-flyout .mega-sub-menu{margin-bottom:2rem!important}.mega-menu-flyout .mega-sub-menu .mega-menu-item{padding:0 .5rem!important}.mega-menu-flyout .mega-sub-menu .mega-menu-item .mega-menu-link{font-weight:200!important}.mega-menu-flyout .mega-sub-menu .mega-menu-item:last-child .mega-menu-link{padding-bottom:.5rem!important;border-bottom:2px solid var(--wp--preset--color--symeres-secondary)!important}.mega-menu>.mega-toggle-on>.mega-menu-link{position:static!important}.mega-menu>.mega-toggle-on>.mega-menu-link:before{content:none!important}.footer__content{grid-template-columns:1fr;padding-bottom:.5rem}.footer__content--logo{padding:1rem 0}.footer__logo{margin:0 auto;width:100%;max-width:186px}.footer__block li,.footer__block p{font-size:18px!important;font-size:1.125rem!important}.footer__block--social{margin-left:0;margin-top:2rem}.footer__block--social h4{line-height:1.1;margin-bottom:.5rem}.footer__block--social>*{flex:0 0 100%;text-align:center;justify-content:center}}#ez-toc-container{--anchorlist-width:180px;width:100%;max-width:var(--anchorlist-width);position:absolute;inset:0 0 5rem auto;z-index:10;display:flex;align-items:flex-end}#ez-toc-container .ez-toc-title{display:none}#ez-toc-container nav{font-size:15px;font-size:.9375rem;line-height:1.1;background-color:var(--wp--preset--color--symeres-grey);border-radius:8px;padding:0 1rem;position:sticky;bottom:4rem}#ez-toc-container nav:after,#ez-toc-container nav:before{content:"";width:var(--anchorlist-width);height:var(--anchorlist-width);display:block;background:var(--wp--preset--color--symeres-grey);position:absolute;border-radius:8px;clip-path:url(#hexagon);left:0;z-index:-1}#ez-toc-container nav::before{top:-3rem}#ez-toc-container nav::after{bottom:-3rem}#ez-toc-container ul{list-style:none;margin:0;padding:0}#ez-toc-container li{border-bottom:1px solid var(--wp--preset--color--symeres-primary);padding:.5rem 0}#ez-toc-container li:last-child{border-bottom:0}#ez-toc-container a:focus-visible,#ez-toc-container a:hover{color:var(--wp--preset--color--symeres-font)}.events{background-position:top center}.events{width:100%;background-color:var(--wp--preset--color--symeres-grey);display:flex;justify-content:center;padding:0 1rem;background-image:url(https://symeres.com/wp-content/themes/symeres-2023/dist/img/backgrounds/bg-events-odd.svg);background-repeat:no-repeat}.events:nth-child(odd){background-color:var(--wp--preset--color--symeres-white)}.events:nth-child(odd){background-image:url(https://symeres.com/wp-content/themes/symeres-2023/dist/img/backgrounds/bg-events-even.svg)}.contact__locations ul li button span{font-weight:400!important;font-family:canada-type-gibson,sans-serif}.contact__locations{border-top:3px solid var(--wp--preset--color--symeres-dgrey);margin:2rem 0;padding-top:1rem}.contact__locations ul{display:flex;flex-wrap:wrap;list-style:none;margin:0 -.25rem;padding:0}.contact__locations ul li{padding:0 .25rem;flex:0 0 16.6666666667%;width:16.6666666667%}.contact__locations ul li button{appearance:none;border:0;cursor:pointer;display:flex;aspect-ratio:1/1.1;background-color:var(--wp--preset--color--symeres-font);clip-path:url(#hexagon);color:var(--wp--preset--color--symeres-white);text-decoration:none;justify-content:center;align-items:center;padding:1rem;width:100%}.contact__locations ul li button span{display:block;text-align:center;padding:.25rem 0;border-width:3px 0;border-style:solid;border-color:currentColor;font-size:19px;font-size:1.1875rem}.contact__locations ul li button.active,.contact__locations ul li button:hover{background-color:var(--wp--preset--color--symeres-primary)!important}.contact__address>div{display:none;justify-content:space-between;gap:2rem;margin-top:2rem;grid-template-columns:repeat(3,1fr)}.contact__address>div.active{display:grid}@media only screen and (max-width :991px){.contact__locations{margin:2rem 0 0}.contact__locations ul{flex-wrap:wrap;justify-content:center}.contact__locations ul li{flex:0 0 33.3333333333%;width:33.3333333333%;max-width:10rem;padding-bottom:1rem}.contact__address{margin-top:1rem;flex-wrap:wrap;justify-content:flex-start;gap:0 2rem}.contact__address h3{flex:0 0 100%}}.downloads__content,.downloads__label{background-image:var(--wpr-bg-69fa0626-8428-4f4b-ac3c-95cbbe8eba4e);background-position:left center;background-size:cover}.downloads{margin-bottom:2rem;clear:both}.downloads__label{font-family:canada-type-gibson,sans-serif;font-weight:600!important}.downloads__aside ul li button,.downloads__label{background-color:transparent;border:0;appearance:none;cursor:pointer}.downloads__aside{--downloads-width:104px;--downloads-height:118px;display:none;position:fixed;right:0;top:10rem;z-index:10;color:var(--wp--preset--color--symeres-font)}.downloads__aside h3{font-size:18px;font-size:1.125rem;margin-bottom:1rem}.downloads__aside ul{list-style:none;margin:0;padding:0}.downloads__aside ul li{padding:.25rem .125rem;font-size:16px;font-size:1rem;display:flex}.downloads__aside ul li span{flex:0 0 24px;padding-top:2px}.downloads__aside ul li button{height:24px;padding:4px}.downloads__aside ul li svg{width:16px;height:16px;margin-right:.25rem}.downloads__aside ul li svg.downloads__icon{color:var(--wp--preset--color--symeres-white)}.downloads__aside input{width:100%;padding:.5rem}.downloads__aside label[for=agreement]{display:flex;font-size:16px!important;font-size:1rem!important}.downloads__aside label[for=agreement] a{color:var(--wp--preset--color--symeres-font)}.downloads__label,.downloads__label span{color:var(--wp--preset--color--symeres-white);position:absolute}.downloads__content{padding:2rem 2rem 2rem 10rem;overflow-y:auto;min-height:460px;width:620px;flex-wrap:wrap;align-content:flex-start;display:none}.downloads__content>*{flex:0 0 100%}.downloads__label{display:flex;justify-content:flex-end;align-items:center;min-width:90px;height:72px;padding-right:1rem;right:100%;top:2rem;z-index:-1}.downloads__label span{top:-10px;left:10px;background-color:red;display:inline-flex;justify-content:center;align-items:center;width:24px;height:24px;border-radius:12px;font-size:16px;font-size:1rem}.downloads__label svg{width:30px;height:42px}.downloads__close{border:0;cursor:pointer;display:inline-block;position:absolute;right:1rem;background-color:transparent}.downloads__close svg{width:18px;height:18px;color:var(--wp--preset--color--symeres-font)}.downloads__files>div{margin-bottom:1rem;padding-right:1rem;height:94px;overflow-y:scroll}.downloads__files>div::-webkit-scrollbar{width:8px}.downloads__files>div::-webkit-scrollbar-track{background-color:rgba(255,255,255,.3)}.downloads__files>div::-webkit-scrollbar-thumb{background-color:var(--wp--preset--color--symeres-white)}.downloads__files h3{display:inline-block;border-bottom:4px solid currentColor;padding-bottom:.35em;padding-right:5rem;margin:0 0 1.6rem;font-size:33px;font-size:2.0625rem}.downloads__form p{margin-bottom:.5rem}.downloads__form button.button,.downloads__form input{display:block}@media only screen and (max-width :567px){.downloads__content{position:fixed;inset:2rem 2rem auto 2rem;min-height:0;width:auto;height:auto;padding:2rem;background-image:none;background-color:var(--wp--preset--color--symeres-secondary);border-radius:8px}.downloads__files>div{height:121px}}.downloads__aside .button,.wp-site-blocks .button{appearance:none;background-color:var(--wp--preset--color--symeres-font);border:1px solid var(--wp--preset--color--symeres-font);border-radius:0;color:var(--wp--preset--color--symeres-white)!important;padding:.4rem 2rem;white-space:nowrap;font-size:18px!important;font-size:1.125rem!important;font-family:canada-type-gibson,sans-serif!important;font-weight:200!important;text-decoration:none!important;cursor:pointer}.downloads__aside .button:focus,.downloads__aside .button:hover,.wp-site-blocks .button:focus,.wp-site-blocks .button:hover{background-color:var(--wp--preset--color--symeres-white);color:var(--wp--preset--color--symeres-font)!important}.downloads__aside .button--primary,.wp-site-blocks .button--primary{border:1px solid var(--wp--preset--color--symeres-primary);background-color:var(--wp--preset--color--symeres-primary);color:var(--wp--preset--color--symeres-white)!important}.downloads__aside .button--primary:focus,.downloads__aside .button--primary:hover,.wp-site-blocks .button--primary:focus,.wp-site-blocks .button--primary:hover{background-color:var(--wp--preset--color--symeres-white)!important;color:var(--wp--preset--color--symeres-primary)!important}@media only screen and (max-width :1229px){#ez-toc-container{display:none}.contact__locations ul li a span{font-size:15px;font-size:.9375rem}.downloads__aside .button,.wp-site-blocks .button{font-size:15px!important;font-size:.9375rem!important;padding:.4rem 1rem}}.downloads__aside .form,.wp-site-blocks .form{display:flex;flex-wrap:wrap;align-content:flex-start;width:100%}.downloads__aside .form label,.wp-site-blocks .form label{font-size:18px;font-size:1.125rem;font-family:canada-type-gibson,sans-serif;font-weight:400!important}.downloads__aside .form label>span,.wp-site-blocks .form label>span{color:#c00;font-family:canada-type-gibson,sans-serif;font-weight:600!important;margin-left:.125rem}.downloads__aside .form input[type=email],.downloads__aside .form input[type=number],.downloads__aside .form input[type=search],.downloads__aside .form input[type=text],.downloads__aside .form input[type=time],.downloads__aside .form input[type=url],.downloads__aside .form select,.downloads__aside .form textarea,.wp-site-blocks .form input[type=email],.wp-site-blocks .form input[type=number],.wp-site-blocks .form input[type=search],.wp-site-blocks .form input[type=text],.wp-site-blocks .form input[type=time],.wp-site-blocks .form input[type=url],.wp-site-blocks .form select,.wp-site-blocks .form textarea{width:100%;border:1px solid var(--wp--preset--color--symeres-dgrey);padding:.5rem .25rem;margin:0;font-family:canada-type-gibson,sans-serif;font-weight:200!important;font-size:16px;font-size:1rem;color:var(--wp--preset--color--symeres-font);position:relative}.downloads__aside .form input[type=email]::placeholder,.downloads__aside .form input[type=number]::placeholder,.downloads__aside .form input[type=search]::placeholder,.downloads__aside .form input[type=text]::placeholder,.downloads__aside .form input[type=time]::placeholder,.downloads__aside .form input[type=url]::placeholder,.downloads__aside .form select::placeholder,.downloads__aside .form textarea::placeholder,.wp-site-blocks .form input[type=email]::placeholder,.wp-site-blocks .form input[type=number]::placeholder,.wp-site-blocks .form input[type=search]::placeholder,.wp-site-blocks .form input[type=text]::placeholder,.wp-site-blocks .form input[type=time]::placeholder,.wp-site-blocks .form input[type=url]::placeholder,.wp-site-blocks .form select::placeholder,.wp-site-blocks .form textarea::placeholder{color:var(--wp--preset--color--symeres-font);opacity:.3}.downloads__aside .form select,.wp-site-blocks .form select{flex:1;padding:.5rem .5rem .5rem .25rem}.downloads__aside .form input[type=checkbox],.downloads__aside .form input[type=radio],.wp-site-blocks .form input[type=checkbox],.wp-site-blocks .form input[type=radio]{width:21px;height:21px;cursor:pointer;vertical-align:text-bottom}.downloads__aside .form input[type=checkbox]+label,.downloads__aside .form input[type=radio]+label,.wp-site-blocks .form input[type=checkbox]+label,.wp-site-blocks .form input[type=radio]+label{margin-left:.25rem;font-family:canada-type-gibson,sans-serif;font-weight:200!important;font-size:21px;font-size:1.3125rem}.downloads__aside .form__row,.wp-site-blocks .form__row{flex:0 0 100%;padding:.25rem 0;margin-bottom:.6rem;display:flex;gap:1rem}.downloads__aside .form__col,.wp-site-blocks .form__col{width:100%}@media only screen and (max-width :1229px){.downloads__aside .form .form__col,.wp-site-blocks .form .form__col{width:100%!important}.downloads__aside .form label,.wp-site-blocks .form label{font-size:15px;font-size:.9375rem}.downloads__aside .form input[type=email],.downloads__aside .form input[type=number],.downloads__aside .form input[type=search],.downloads__aside .form input[type=text],.downloads__aside .form input[type=time],.downloads__aside .form input[type=url],.downloads__aside .form select,.downloads__aside .form textarea,.wp-site-blocks .form input[type=email],.wp-site-blocks .form input[type=number],.wp-site-blocks .form input[type=search],.wp-site-blocks .form input[type=text],.wp-site-blocks .form input[type=time],.wp-site-blocks .form input[type=url],.wp-site-blocks .form select,.wp-site-blocks .form textarea{font-size:18px;font-size:1.125rem}.downloads__aside .form input[type=checkbox],.downloads__aside .form input[type=radio],.wp-site-blocks .form input[type=checkbox],.wp-site-blocks .form input[type=radio]{width:15px;height:15px}.downloads__aside .form input[type=checkbox]+label,.downloads__aside .form input[type=radio]+label,.wp-site-blocks .form input[type=checkbox]+label,.wp-site-blocks .form input[type=radio]+label{font-size:15px;font-size:.9375rem}.downloads__aside .form__row,.wp-site-blocks .form__row{justify-content:flex-start}}.downloads__aside .hero,.wp-site-blocks .hero{width:100%}.downloads__aside .hero__top,.wp-site-blocks .hero__top{padding:1rem 0;min-height:21rem;background-repeat:no-repeat;background-size:cover;background-position:center;display:flex;justify-content:center;align-items:center}.downloads__aside .hero__content,.wp-site-blocks .hero__content{width:100%;max-width:var(--wp--style--global--content-size);padding:0 1rem}.downloads__aside .hero__content h1,.downloads__aside .hero__content h2,.wp-site-blocks .hero__content h1,.wp-site-blocks .hero__content h2{color:var(--wp--preset--color--symeres-primary);font-size:45px;font-size:2.8125rem;margin:0 0 1.2rem;display:inline-block;border-bottom:4px solid currentColor;padding-bottom:.35em}.downloads__aside .hero__heading h1,.wp-site-blocks .hero__heading h1{color:var(--wp--preset--color--symeres-white)}.downloads__aside .hero__content p,.wp-site-blocks .hero__content p{font-size:21px;font-size:1.3125rem;margin:0 0 1.2rem}.downloads__aside .hero__content :last-child,.wp-site-blocks .hero__content :last-child{margin:0}.downloads__aside .hero__heading,.wp-site-blocks .hero__heading{width:234px;height:264px;background-color:var(--wp--preset--color--symeres-primary);display:flex;justify-content:center;align-items:center;padding:1.5rem;clip-path:url(#hexagon);position:relative}.downloads__aside .hero__heading svg,.wp-site-blocks .hero__heading svg{color:var(--wp--preset--color--symeres-white);width:50px;height:60px;position:absolute;top:1rem}.downloads__aside .hero__heading h1,.wp-site-blocks .hero__heading h1{margin:1.25rem 0 0!important;border-width:3px 0;border-style:solid;border-color:currentColor;text-align:center;line-height:1.1;padding:.35rem 0 .5rem;font-size:24px;font-size:1.5rem;display:flex;width:100%;min-height:72px;justify-content:center;align-items:center}@media only screen and (max-width :1229px){.downloads__aside .hero__heading,.wp-site-blocks .hero__heading{margin:0 auto!important}.downloads__aside .hero__content h2,.wp-site-blocks .hero__content h2{font-size:30px;font-size:1.875rem}.downloads__aside .hero__content p,.wp-site-blocks .hero__content p{font-size:15px;font-size:.9375rem}}.downloads__aside .block,.wp-site-blocks .block{background-color:var(--wp--preset--color--symeres-white);background-image:var(--wpr-bg-3d55c258-0ba7-4ea4-8226-8864b3f0b8f7);background-repeat:repeat-y;background-position:center;background-size:cover;width:100vw;display:flex;justify-content:center;overflow-x:hidden}.downloads__aside .block .block__text,.wp-site-blocks .block .block__text{color:var(--wp--preset--color--symeres-font)}.downloads__aside .block .block__text h2,.wp-site-blocks .block .block__text h2{color:var(--wp--preset--color--symeres-primary)}.downloads__aside .block--primary,.wp-site-blocks .block--primary{background-color:var(--wp--preset--color--symeres-primary);background-image:none}.downloads__aside .block--primary .block__text,.downloads__aside .block--primary .block__text h2,.wp-site-blocks .block--primary .block__text,.wp-site-blocks .block--primary .block__text h2{color:var(--wp--preset--color--symeres-white)}.downloads__aside .block__content,.wp-site-blocks .block__content{flex:1;padding:0 1rem;max-width:var(--wp--style--global--wide-size);display:grid;grid-template-columns:11.4fr 33.8fr 4.8fr 4.8fr 33.8fr 11.4fr}.downloads__aside .block__text,.wp-site-blocks .block__text{grid-column:2/4;padding:4rem 0}.downloads__aside .block__text h2,.wp-site-blocks .block__text h2{font-size:45px;font-size:2.8125rem;line-height:1.1;margin:0 0 1.6rem}.downloads__aside .block__text p,.wp-site-blocks .block__text p{margin:0 0 1.6rem}.downloads__aside .block__text>:last-child,.wp-site-blocks .block__text>:last-child{margin:0}.downloads__aside .block__figure,.wp-site-blocks .block__figure{grid-column:5/7;align-self:end;height:100%;display:flex;align-items:stretch}.downloads__aside .block__figure img,.wp-site-blocks .block__figure img{width:auto;height:100%}.downloads__aside .block__content--right .block__text,.wp-site-blocks .block__content--right .block__text{order:1;grid-column:4/6}.downloads__aside .block__content--right .block__figure,.wp-site-blocks .block__content--right .block__figure{grid-column:1/3;order:0;height:100%;align-self:end;justify-self:flex-end}@media only screen and (max-width :1229px){.downloads__aside .block__content,.wp-site-blocks .block__content{display:flex;flex-wrap:wrap}.downloads__aside .block__figure,.downloads__aside .block__text,.wp-site-blocks .block__figure,.wp-site-blocks .block__text{height:auto!important;text-align:center}.downloads__aside .block__text,.wp-site-blocks .block__text{flex:0 0 100%;padding:2rem 0;order:1!important}.downloads__aside .block__text h2,.wp-site-blocks .block__text h2{font-size:30px;font-size:1.875rem}.downloads__aside .block__text ul,.wp-site-blocks .block__text ul{list-style:none;font-family:canada-type-gibson,sans-serif;font-weight:400!important}.downloads__aside .block__figure,.wp-site-blocks .block__figure{justify-content:center;order:2!important;margin:0 auto}.downloads__aside .block__figure img,.wp-site-blocks .block__figure img{width:100%;height:auto;max-width:450px;object-fit:contain}}.owl-carousel,.owl-carousel .owl-item{-webkit-tap-highlight-color:transparent;position:relative}.owl-carousel{display:none;width:100%;z-index:1}.owl-carousel .owl-stage{position:relative;-ms-touch-action:pan-Y;touch-action:manipulation;-moz-backface-visibility:hidden}.owl-carousel .owl-stage:after{content:".";display:block;clear:both;visibility:hidden;line-height:0;height:0}.owl-carousel .owl-stage-outer{position:relative;overflow:hidden;-webkit-transform:translate3d(0,0,0)}.owl-carousel .owl-item{-webkit-backface-visibility:hidden;-moz-backface-visibility:hidden;-ms-backface-visibility:hidden;-webkit-transform:translate3d(0,0,0);-moz-transform:translate3d(0,0,0);-ms-transform:translate3d(0,0,0)}.owl-carousel .owl-item{min-height:1px;float:left;-webkit-backface-visibility:hidden;-webkit-touch-callout:none}.owl-carousel .owl-item img{display:block;width:100%}.owl-carousel .owl-dots.disabled,.owl-carousel .owl-nav.disabled{display:none}.no-js .owl-carousel,.owl-carousel.owl-loaded{display:block}.owl-carousel .owl-dot,.owl-carousel .owl-nav .owl-next,.owl-carousel .owl-nav .owl-prev{cursor:pointer;-webkit-user-select:none;-khtml-user-select:none;-moz-user-select:none;-ms-user-select:none;user-select:none}.owl-carousel .owl-nav button.owl-next,.owl-carousel .owl-nav button.owl-prev,.owl-carousel button.owl-dot{background:0 0;color:inherit;border:none;padding:0!important;font:inherit}.owl-carousel.owl-loading{opacity:0;display:block}.owl-carousel.owl-hidden{opacity:0}.owl-carousel.owl-refresh .owl-item{visibility:hidden}.owl-carousel.owl-drag .owl-item{-ms-touch-action:pan-y;touch-action:pan-y;-webkit-user-select:none;-moz-user-select:none;-ms-user-select:none;user-select:none}.owl-carousel.owl-grab{cursor:move;cursor:grab}.owl-carousel.owl-rtl{direction:rtl}.owl-carousel.owl-rtl .owl-item{float:right}.owl-carousel .animated{animation-duration:1s;animation-fill-mode:both}.owl-carousel .owl-animated-in{z-index:0}.owl-carousel .owl-animated-out{z-index:1}.owl-height{transition:height .5s ease-in-out}.owl-carousel .owl-item .owl-lazy{opacity:0;transition:opacity .4s ease}.owl-carousel .owl-item .owl-lazy:not([src]),.owl-carousel .owl-item .owl-lazy[src^=""]{max-height:0}.owl-carousel .owl-item img.owl-lazy{transform-style:preserve-3d}.owl-carousel .owl-video-wrapper{position:relative;height:100%;background:#000}.owl-carousel .owl-video-play-icon{position:absolute;height:80px;width:80px;left:50%;top:50%;margin-left:-40px;margin-top:-40px;background:var(--wpr-bg-63ad469a-8a54-49b6-ab4e-f6c7ed24f872) no-repeat;cursor:pointer;z-index:1;-webkit-backface-visibility:hidden;transition:transform .1s ease}.owl-carousel .owl-video-play-icon:hover{-ms-transform:scale(1.3,1.3);transform:scale(1.3,1.3)}.owl-carousel .owl-video-playing .owl-video-play-icon,.owl-carousel .owl-video-playing .owl-video-tn{display:none}.owl-carousel .owl-video-tn{opacity:0;height:100%;background-position:center center;background-repeat:no-repeat;background-size:contain;transition:opacity .4s ease}.owl-carousel .owl-video-frame{position:relative;z-index:1;height:100%;width:100%}@font-face{font-family:canada-type-gibson;font-style:normal;font-weight:200;font-display:swap;src:url('https://symeres.com/wp-content/themes/symeres-2023/assets/fonts/Inter-Regular.ttf') format('truetype')}@font-face{font-family:canada-type-gibson;font-style:normal;font-weight:400;font-display:swap;src:url('https://symeres.com/wp-content/themes/symeres-2023/assets/fonts/Inter-Bold.ttf') format('truetype')}</style><link rel="preload" data-rocket-preload as="image" href="https://symeres.com/wp-content/themes/symeres-2023/dist/img/backgrounds/bg-home-events.svg" fetchpriority="high"> <link rel='dns-prefetch' href='//js-eu1.hs-scripts.com' /> <link rel='dns-prefetch' href='//use.typekit.net' /> <link rel="alternate" type="application/rss+xml" title="Symeres » Feed" href="https://symeres.com/feed/" /> <link rel="alternate" type="application/rss+xml" title="Symeres » Comments Feed" href="https://symeres.com/comments/feed/" /> <style id='wp-block-heading-inline-css'></style> <style id='wp-block-paragraph-inline-css'></style> <style id='wp-block-list-inline-css'></style> <style id='wp-block-spacer-inline-css'></style> <style id='wp-block-separator-inline-css'></style> <style id='wp-block-separator-theme-inline-css'></style> <style id='wp-block-image-inline-css'></style> <style id='wp-block-image-theme-inline-css'></style> <style id='wp-block-site-logo-inline-css'></style> <style id='wp-block-group-inline-css'></style> <style id='wp-block-group-theme-inline-css'></style> <style id='wp-block-template-part-theme-inline-css'></style> <style id='wp-block-post-content-inline-css'></style> <style id='wp-emoji-styles-inline-css'></style> <style id='wp-block-library-inline-css'></style> <style id='global-styles-inline-css'></style> <style id='wp-block-template-skip-link-inline-css'></style> <style id='rocket-lazyload-inline-css'> .rll-youtube-player{position:relative;padding-bottom:56.23%;height:0;overflow:hidden;max-width:100%;}.rll-youtube-player:focus-within{outline: 2px solid currentColor;outline-offset: 5px;}.rll-youtube-player iframe{position:absolute;top:0;left:0;width:100%;height:100%;z-index:100;background:0 0}.rll-youtube-player img{bottom:0;display:block;left:0;margin:auto;max-width:100%;width:100%;position:absolute;right:0;top:0;border:none;height:auto;-webkit-transition:.4s all;-moz-transition:.4s all;transition:.4s all}.rll-youtube-player img:hover{-webkit-filter:brightness(75%)}.rll-youtube-player .play{height:100%;width:100%;left:0;top:0;position:absolute;background:var(--wpr-bg-cc40fd16-4e7e-4ff9-a489-4a5dd4e8e6d4) no-repeat center;background-color: transparent !important;cursor:pointer;border:none;}.wp-embed-responsive .wp-has-aspect-ratio .rll-youtube-player{position:absolute;padding-bottom:0;width:100%;height:100%;top:0;bottom:0;left:0;right:0} </style> <script type="rocketlazyloadscript" data-rocket-src="https://symeres.com/wp-includes/js/jquery/jquery.min.js?ver=3.7.1" id="jquery-core-js" data-rocket-defer defer></script> <script type="rocketlazyloadscript" data-rocket-src="https://symeres.com/wp-includes/js/jquery/jquery-migrate.min.js?ver=3.4.1" id="jquery-migrate-js" data-rocket-defer defer></script> <script type="rocketlazyloadscript" data-rocket-src="https://symeres.com/wp-content/themes/symeres-2023/dist/js/app.min.js?ver=6.7.1" id="symeres-js-js" data-rocket-defer defer></script> <link rel="https://api.w.org/" href="https://symeres.com/wp-json/" /><link rel="alternate" title="JSON" type="application/json" href="https://symeres.com/wp-json/wp/v2/pages/1749" /><link rel="EditURI" type="application/rsd+xml" title="RSD" href="https://symeres.com/xmlrpc.php?rsd" /> <meta name="generator" content="WordPress 6.7.1" /> <link rel='shortlink' href='https://symeres.com/?p=1749' /> <link rel="alternate" title="oEmbed (JSON)" type="application/json+oembed" href="https://symeres.com/wp-json/oembed/1.0/embed?url=https%3A%2F%2Fsymeres.com%2Fservices%2Fadmescope-adme-tox%2F" /> <link rel="alternate" title="oEmbed (XML)" type="text/xml+oembed" href="https://symeres.com/wp-json/oembed/1.0/embed?url=https%3A%2F%2Fsymeres.com%2Fservices%2Fadmescope-adme-tox%2F&format=xml" /> <script type="rocketlazyloadscript" data-minify="1" data-rocket-type="text/javascript" data-rocket-src="https://symeres.com/wp-content/cache/min/1/sidebarv2.js?ver=1732266183" async="true"></script>  <script type="rocketlazyloadscript" class="hsq-set-content-id" data-content-id="standard-page"> var _hsq = _hsq || []; _hsq.push(["setContentType", "standard-page"]); </script>  <style class='wp-fonts-local'></style> <link rel="icon" href="https://symeres.com/wp-content/uploads/2023/02/cropped-favicon-1-32x32.png" sizes="32x32" /> <link rel="icon" href="https://symeres.com/wp-content/uploads/2023/02/cropped-favicon-1-192x192.png" sizes="192x192" /> <link rel="apple-touch-icon" href="https://symeres.com/wp-content/uploads/2023/02/cropped-favicon-1-180x180.png" /> <meta name="msapplication-TileImage" content="https://symeres.com/wp-content/uploads/2023/02/cropped-favicon-1-270x270.png" /> <link rel="icon" href="" sizes="32x32"><style type="text/css"></style> <noscript><style id="rocket-lazyload-nojs-css">.rll-youtube-player, [data-lazy-src]{display:none !important;}</style></noscript><style id="wpr-lazyload-bg-container"></style><style id="wpr-lazyload-bg-exclusion">.main--page{--wpr-bg-026c42f8-915a-4ddb-96e4-06800b8fc426: url('https://symeres.com/wp-content/themes/symeres-2023/dist/img/backgrounds/bg-home-events.svg');}</style> <noscript> <style id="wpr-lazyload-bg-nostyle">.owl-carousel .owl-video-play-icon{--wpr-bg-63ad469a-8a54-49b6-ab4e-f6c7ed24f872: url('https://symeres.com/wp-content/themes/symeres-2023/dist/css/owl.video.play.png');}.mega-menu-row .mega-sub-menu .mega-menu-column .mega-sub-menu .mega-sub-menu .mega-menu-item .mega-menu-link:before{--wpr-bg-3ae9b33c-5882-493a-b626-cdf397e1a8a2: url('https://symeres.com/wp-content/themes/symeres-2023/dist/img/mega-menu-item-angle-right.svg');}.events{--wpr-bg-35f30d74-2a52-4520-8792-0ac4b9b772ff: url('https://symeres.com/wp-content/themes/symeres-2023/dist/img/backgrounds/bg-events-odd.svg');}.events:nth-child(odd){--wpr-bg-ecad0d51-ed74-4445-a3f9-ce4813198aa1: url('https://symeres.com/wp-content/themes/symeres-2023/dist/img/backgrounds/bg-events-even.svg');}.downloads__content,.downloads__label{--wpr-bg-69fa0626-8428-4f4b-ac3c-95cbbe8eba4e: url('https://symeres.com/wp-content/themes/symeres-2023/dist/img/download-label.svg');}.downloads__aside .block,.wp-site-blocks .block{--wpr-bg-3d55c258-0ba7-4ea4-8226-8864b3f0b8f7: url('https://symeres.com/wp-content/themes/symeres-2023/dist/img/backgrounds/bg-home-contact.svg');}.rll-youtube-player .play{--wpr-bg-cc40fd16-4e7e-4ff9-a489-4a5dd4e8e6d4: url('https://symeres.com/wp-content/plugins/wp-rocket/assets/img/youtube.png');}</style> </noscript> <script type="application/javascript">const rocket_pairs = [{"selector":".owl-carousel .owl-video-play-icon","style":".owl-carousel .owl-video-play-icon{--wpr-bg-63ad469a-8a54-49b6-ab4e-f6c7ed24f872: url('https:\/\/symeres.com\/wp-content\/themes\/symeres-2023\/dist\/css\/owl.video.play.png');}","hash":"63ad469a-8a54-49b6-ab4e-f6c7ed24f872","url":"https:\/\/symeres.com\/wp-content\/themes\/symeres-2023\/dist\/css\/owl.video.play.png"},{"selector":".mega-menu-row .mega-sub-menu .mega-menu-column .mega-sub-menu .mega-sub-menu .mega-menu-item .mega-menu-link","style":".mega-menu-row .mega-sub-menu .mega-menu-column .mega-sub-menu .mega-sub-menu .mega-menu-item .mega-menu-link:before{--wpr-bg-3ae9b33c-5882-493a-b626-cdf397e1a8a2: url('https:\/\/symeres.com\/wp-content\/themes\/symeres-2023\/dist\/img\/mega-menu-item-angle-right.svg');}","hash":"3ae9b33c-5882-493a-b626-cdf397e1a8a2","url":"https:\/\/symeres.com\/wp-content\/themes\/symeres-2023\/dist\/img\/mega-menu-item-angle-right.svg"},{"selector":".events","style":".events{--wpr-bg-35f30d74-2a52-4520-8792-0ac4b9b772ff: url('https:\/\/symeres.com\/wp-content\/themes\/symeres-2023\/dist\/img\/backgrounds\/bg-events-odd.svg');}","hash":"35f30d74-2a52-4520-8792-0ac4b9b772ff","url":"https:\/\/symeres.com\/wp-content\/themes\/symeres-2023\/dist\/img\/backgrounds\/bg-events-odd.svg"},{"selector":".events:nth-child(odd)","style":".events:nth-child(odd){--wpr-bg-ecad0d51-ed74-4445-a3f9-ce4813198aa1: url('https:\/\/symeres.com\/wp-content\/themes\/symeres-2023\/dist\/img\/backgrounds\/bg-events-even.svg');}","hash":"ecad0d51-ed74-4445-a3f9-ce4813198aa1","url":"https:\/\/symeres.com\/wp-content\/themes\/symeres-2023\/dist\/img\/backgrounds\/bg-events-even.svg"},{"selector":".downloads__content,.downloads__label","style":".downloads__content,.downloads__label{--wpr-bg-69fa0626-8428-4f4b-ac3c-95cbbe8eba4e: url('https:\/\/symeres.com\/wp-content\/themes\/symeres-2023\/dist\/img\/download-label.svg');}","hash":"69fa0626-8428-4f4b-ac3c-95cbbe8eba4e","url":"https:\/\/symeres.com\/wp-content\/themes\/symeres-2023\/dist\/img\/download-label.svg"},{"selector":".downloads__aside .block,.wp-site-blocks .block","style":".downloads__aside .block,.wp-site-blocks .block{--wpr-bg-3d55c258-0ba7-4ea4-8226-8864b3f0b8f7: url('https:\/\/symeres.com\/wp-content\/themes\/symeres-2023\/dist\/img\/backgrounds\/bg-home-contact.svg');}","hash":"3d55c258-0ba7-4ea4-8226-8864b3f0b8f7","url":"https:\/\/symeres.com\/wp-content\/themes\/symeres-2023\/dist\/img\/backgrounds\/bg-home-contact.svg"},{"selector":".rll-youtube-player .play","style":".rll-youtube-player .play{--wpr-bg-cc40fd16-4e7e-4ff9-a489-4a5dd4e8e6d4: url('https:\/\/symeres.com\/wp-content\/plugins\/wp-rocket\/assets\/img\/youtube.png');}","hash":"cc40fd16-4e7e-4ff9-a489-4a5dd4e8e6d4","url":"https:\/\/symeres.com\/wp-content\/plugins\/wp-rocket\/assets\/img\/youtube.png"}]; const rocket_excluded_pairs = [{"selector":".main--page","style":".main--page{--wpr-bg-026c42f8-915a-4ddb-96e4-06800b8fc426: url('https:\/\/symeres.com\/wp-content\/themes\/symeres-2023\/dist\/img\/backgrounds\/bg-home-events.svg');}","hash":"026c42f8-915a-4ddb-96e4-06800b8fc426","url":"https:\/\/symeres.com\/wp-content\/themes\/symeres-2023\/dist\/img\/backgrounds\/bg-home-events.svg"}];</script><meta name="generator" content="WP Rocket 3.17.3" data-wpr-features="wpr_lazyload_css_bg_img wpr_remove_unused_css wpr_delay_js wpr_defer_js wpr_minify_js wpr_lazyload_images wpr_lazyload_iframes wpr_oci wpr_image_dimensions wpr_minify_css wpr_desktop wpr_preload_links" /></head> <body class="page-template-default page page-id-1749 page-child parent-pageid-210 wp-custom-logo wp-embed-responsive mega-menu-max-mega-menu-1"> <div class="wp-site-blocks"><header class="header wp-block-template-part"> <div class="wp-block-group header__content is-layout-flow wp-block-group-is-layout-flow"><div class="header__logo wp-block-site-logo"><a href="https://symeres.com/" class="custom-logo-link" rel="home"><img width="240" height="240" src="https://symeres.com/wp-content/uploads/2022/12/symeres-logo-web.svg" class="custom-logo" alt="Logo Symeres" decoding="async" fetchpriority="high" /></a></div> <div id="mega-menu-wrap-max_mega_menu_1" class="mega-menu-wrap"><div class="mega-menu-toggle"><div class="mega-toggle-blocks-left"></div><div class="mega-toggle-blocks-center"></div><div class="mega-toggle-blocks-right"><div class='mega-toggle-block mega-menu-toggle-animated-block mega-toggle-block-0' id='mega-toggle-block-0'><button aria-label="Toggle Menu" class="mega-toggle-animated mega-toggle-animated-slider" type="button" aria-expanded="false"> <span class="mega-toggle-animated-box"> <span class="mega-toggle-animated-inner"></span> </span> </button></div></div></div><ul id="mega-menu-max_mega_menu_1" class="mega-menu max-mega-menu mega-menu-horizontal mega-no-js" data-event="hover_intent" data-effect="fade_up" data-effect-speed="200" data-effect-mobile="disabled" data-effect-speed-mobile="0" data-mobile-force-width="body" data-second-click="go" data-document-click="collapse" data-vertical-behaviour="standard" data-breakpoint="1230" data-unbind="true" data-mobile-state="collapse_all" data-mobile-direction="vertical" data-hover-intent-timeout="300" data-hover-intent-interval="100"><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-current-page-ancestor mega-current-menu-ancestor mega-current-menu-parent mega-current-custom-parent mega-current_page_parent mega-current_page_ancestor mega-menu-item-has-children mega-menu-megamenu mega-align-bottom-left mega-menu-grid mega-menu-item-299' id='mega-menu-item-299'><a class="mega-menu-link" href="https://symeres.com/services/" aria-expanded="false" tabindex="0">Services<span class="mega-indicator"></span></a> <ul class="mega-sub-menu"> <li class='mega-menu-row' id='mega-menu-299-0'> <ul class="mega-sub-menu"> <li class='mega-menu-column mega-menu-columns-3-of-12' id='mega-menu-299-0-0'> <ul class="mega-sub-menu"> <li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-has-children mega-menu-item-3673' id='mega-menu-item-3673'><a class="mega-menu-link" href="https://symeres.com/services/drug-discovery/">Drug Discovery<span class="mega-indicator"></span></a> <ul class="mega-sub-menu"> <li class='mega-menu-item mega-menu-item-type-custom mega-menu-item-object-custom mega-menu-item-2442' id='mega-menu-item-2442'><a class="mega-menu-link" href="https://symeres.com/services/drug-discovery/#design-and-synthesis-from-hit-to-clinical-candidate">Introduction</a></li><li class='mega-menu-item mega-menu-item-type-custom mega-menu-item-object-custom mega-menu-item-2444' id='mega-menu-item-2444'><a class="mega-menu-link" href="https://symeres.com/services/drug-discovery/#Hit_Generation">Hit Generation</a></li><li class='mega-menu-item mega-menu-item-type-custom mega-menu-item-object-custom mega-menu-item-2445' id='mega-menu-item-2445'><a class="mega-menu-link" href="https://symeres.com/services/drug-discovery/#Hit-to-Lead">Hit-to-Lead</a></li><li class='mega-menu-item mega-menu-item-type-custom mega-menu-item-object-custom mega-menu-item-2446' id='mega-menu-item-2446'><a class="mega-menu-link" href="https://symeres.com/services/drug-discovery/#Lead_Optimization">Lead Optimization</a></li><li class='mega-menu-item mega-menu-item-type-custom mega-menu-item-object-custom mega-menu-item-2447' id='mega-menu-item-2447'><a class="mega-menu-link" href="https://symeres.com/services/drug-discovery/#Computational_Chemistry">Computational Chemistry</a></li><li class='mega-menu-item mega-menu-item-type-custom mega-menu-item-object-custom mega-menu-item-2448' id='mega-menu-item-2448'><a class="mega-menu-link" href="https://symeres.com/services/drug-discovery/#Rapid_Analog_Synthesis">Rapid Analog Synthesis</a></li><li class='mega-menu-item mega-menu-item-type-custom mega-menu-item-object-custom mega-menu-item-2443' id='mega-menu-item-2443'><a class="mega-menu-link" href="https://symeres.com/services/drug-discovery/#Integrated_Drug_Discovery">Integrated Drug Discovery</a></li> </ul> </li> </ul> </li><li class='mega-menu-column mega-menu-columns-3-of-12' id='mega-menu-299-0-1'> <ul class="mega-sub-menu"> <li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-has-children mega-menu-item-2943' id='mega-menu-item-2943'><a class="mega-menu-link" href="https://symeres.com/services/synthetic-chemistry/">Synthetic Chemistry<span class="mega-indicator"></span></a> <ul class="mega-sub-menu"> <li class='mega-menu-item mega-menu-item-type-custom mega-menu-item-object-custom mega-menu-item-has-children mega-menu-item-3069' id='mega-menu-item-3069'><a class="mega-menu-link" href="https://symeres.com/services/synthetic-chemistry/#Enabling_technologies" aria-expanded="false">Enabling technologies<span class="mega-indicator"></span></a> <ul class="mega-sub-menu"> <li class='mega-menu-item mega-menu-item-type-custom mega-menu-item-object-custom mega-menu-item-6220' id='mega-menu-item-6220'><a class="mega-menu-link" href="http://symeres.com/biocatalysis/">Biocatalysis</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-6647' id='mega-menu-item-6647'><a class="mega-menu-link" href="https://symeres.com/chemocatalysis/">Chemocatalysis</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-3075' id='mega-menu-item-3075'><a class="mega-menu-link" href="https://symeres.com/chiral-chemistry/">Chiral Chemistry</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-2679' id='mega-menu-item-2679'><a class="mega-menu-link" href="https://symeres.com/electrochemistry/">Electrochemistry</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-3545' id='mega-menu-item-3545'><a class="mega-menu-link" href="https://symeres.com/flow-chemistry/">Flow Chemistry</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-3074' id='mega-menu-item-3074'><a class="mega-menu-link" href="https://symeres.com/photochemistry/">Photochemistry</a></li> </ul> </li><li class='mega-menu-item mega-menu-item-type-custom mega-menu-item-object-custom mega-menu-item-3070' id='mega-menu-item-3070'><a class="mega-menu-link" href="https://symeres.com/services/synthetic-chemistry/#Chemistry_FTE_teams">Chemistry FTE teams</a></li><li class='mega-menu-item mega-menu-item-type-custom mega-menu-item-object-custom mega-menu-item-has-children mega-menu-item-3071' id='mega-menu-item-3071'><a class="mega-menu-link" href="https://symeres.com/services/synthetic-chemistry/#Custom_synthesis" aria-expanded="false">Custom Synthesis<span class="mega-indicator"></span></a> <ul class="mega-sub-menu"> <li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-2143' id='mega-menu-item-2143'><a class="mega-menu-link" href="https://symeres.com/advanced-macrocycles/">Advanced macrocycles</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-2134' id='mega-menu-item-2134'><a class="mega-menu-link" href="https://symeres.com/amino-acids/">Amino Acids</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-2135' id='mega-menu-item-2135'><a class="mega-menu-link" href="https://symeres.com/carbohydrate-chemistry/">Carbohydrate chemistry</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-6775' id='mega-menu-item-6775'><a class="mega-menu-link" href="https://symeres.com/controlled-substances/">Controlled substances</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-2141' id='mega-menu-item-2141'><a class="mega-menu-link" href="https://symeres.com/impurity-synthesis/">Impurity synthesis</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-2142' id='mega-menu-item-2142'><a class="mega-menu-link" href="https://symeres.com/linkers-and-conjugation-chemistry/">Linkers and conjugation chemistry</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-2136' id='mega-menu-item-2136'><a class="mega-menu-link" href="https://symeres.com/lipids/">Lipids</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-3567' id='mega-menu-item-3567'><a class="mega-menu-link" href="https://symeres.com/nucleosides-and-nucleotides/">Nucleosides and Nucleotides</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-2145' id='mega-menu-item-2145'><a class="mega-menu-link" href="https://symeres.com/peptidomimetics/">Peptidomimetics</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-2966' id='mega-menu-item-2966'><a class="mega-menu-link" href="https://symeres.com/positron-emission-tomography/">Positron Emission Tomography</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-2149' id='mega-menu-item-2149'><a class="mega-menu-link" href="https://symeres.com/protacs-and-other-bifunctional-new-modalities/">PROTACs and other Bifunctional New Modalities</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-2132' id='mega-menu-item-2132'><a class="mega-menu-link" href="https://symeres.com/stable-isotope-labeled-compounds/">Stable Isotope-Labeled Compounds</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-7159' id='mega-menu-item-7159'><a class="mega-menu-link" href="https://symeres.com/steroids/">Steroids</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-6917' id='mega-menu-item-6917'><a class="mega-menu-link" href="https://symeres.com/vitamin-d/">Vitamin D</a></li> </ul> </li><li class='mega-menu-item mega-menu-item-type-custom mega-menu-item-object-custom mega-menu-item-3710' id='mega-menu-item-3710'><a class="mega-menu-link" href="https://symeres.com/services/synthetic-chemistry/#Our_product_catalogs">Our product catalogs</a></li> </ul> </li> </ul> </li><li class='mega-menu-column mega-menu-columns-3-of-12' id='mega-menu-299-0-2'> <ul class="mega-sub-menu"> <li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-has-children mega-menu-item-2338' id='mega-menu-item-2338'><a class="mega-menu-link" href="https://symeres.com/services/drug-development/">Drug Development<span class="mega-indicator"></span></a> <ul class="mega-sub-menu"> <li class='mega-menu-item mega-menu-item-type-custom mega-menu-item-object-custom mega-menu-item-2457' id='mega-menu-item-2457'><a class="mega-menu-link" href="https://symeres.com/services/drug-development/">Introduction</a></li><li class='mega-menu-item mega-menu-item-type-custom mega-menu-item-object-custom mega-menu-item-6323' id='mega-menu-item-6323'><a class="mega-menu-link" href="https://symeres.com/services/drug-development/#Developability_Roadmap">Developability Roadmap</a></li><li class='mega-menu-item mega-menu-item-type-custom mega-menu-item-object-custom mega-menu-item-2458' id='mega-menu-item-2458'><a class="mega-menu-link" href="https://symeres.com/services/drug-development/#Process_Research_and_Development">Process Research and Development</a></li><li class='mega-menu-item mega-menu-item-type-custom mega-menu-item-object-custom mega-menu-item-6273' id='mega-menu-item-6273'><a class="mega-menu-link" href="https://symeres.com/services/drug-development/#Non-GMP_scale-up_for_IND-enabling_studies">Non-GMP scale-up for IND-enabling studies</a></li><li class='mega-menu-item mega-menu-item-type-custom mega-menu-item-object-custom mega-menu-item-2459' id='mega-menu-item-2459'><a class="mega-menu-link" href="https://symeres.com/services/drug-development/#GMP_Manufacturing">GMP Manufacturing</a></li><li class='mega-menu-item mega-menu-item-type-custom mega-menu-item-object-custom mega-menu-item-2460' id='mega-menu-item-2460'><a class="mega-menu-link" href="https://symeres.com/services/drug-development/#GMP_Starting_Materials">GMP Starting Materials</a></li><li class='mega-menu-item mega-menu-item-type-custom mega-menu-item-object-custom mega-menu-item-2461' id='mega-menu-item-2461'><a class="mega-menu-link" href="https://symeres.com/services/drug-development/#Solid_State_Chemistry_and_Pre-Formulation_Research">Solid-State Chemistry and Pre-Formulation Research</a></li><li class='mega-menu-item mega-menu-item-type-custom mega-menu-item-object-custom mega-menu-item-6703' id='mega-menu-item-6703'><a class="mega-menu-link" href="https://symeres.com/services/drug-development/#Formulation_Development_and_Clinical_Manufacturing">Formulation Development and Clinical Manufacturing</a></li><li class='mega-menu-item mega-menu-item-type-custom mega-menu-item-object-custom mega-menu-item-7105' id='mega-menu-item-7105'><a class="mega-menu-link" href="https://symeres.com/services/drug-development/#Analytical_Development_Services">Analytical Development Services</a></li><li class='mega-menu-item mega-menu-item-type-custom mega-menu-item-object-custom mega-menu-item-2462' id='mega-menu-item-2462'><a class="mega-menu-link" href="https://symeres.com/services/drug-development/#ICH_Stability_Studies">ICH Stability Studies</a></li><li class='mega-menu-item mega-menu-item-type-custom mega-menu-item-object-custom mega-menu-item-2463' id='mega-menu-item-2463'><a class="mega-menu-link" href="https://symeres.com/services/drug-development/#Quality_Unit">Quality Unit</a></li><li class='mega-menu-item mega-menu-item-type-custom mega-menu-item-object-custom mega-menu-item-2464' id='mega-menu-item-2464'><a class="mega-menu-link" href="https://symeres.com/services/drug-development/#EHS_Compliance">EHS Compliance</a></li> </ul> </li> </ul> </li><li class='mega-menu-column mega-menu-columns-3-of-12' id='mega-menu-299-0-3'> <ul class="mega-sub-menu"> <li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-current-menu-item mega-page_item mega-page-item-1749 mega-current_page_item mega-current-menu-ancestor mega-current-menu-parent mega-current_page_parent mega-current_page_ancestor mega-menu-item-has-children mega-menu-item-2352' id='mega-menu-item-2352'><a class="mega-menu-link" href="https://symeres.com/services/admescope-adme-tox/" aria-current="page">Admescope ADME-Tox<span class="mega-indicator"></span></a> <ul class="mega-sub-menu"> <li class='mega-menu-item mega-menu-item-type-custom mega-menu-item-object-custom mega-current-menu-item mega-menu-item-2466' id='mega-menu-item-2466'><a class="mega-menu-link" href="https://symeres.com/services/admescope-adme-tox" aria-current="page">Introduction</a></li><li class='mega-menu-item mega-menu-item-type-custom mega-menu-item-object-custom mega-current-menu-item mega-menu-item-2467' id='mega-menu-item-2467'><a class="mega-menu-link" href="https://symeres.com/services/admescope-adme-tox/#Physicochemistry_and_binding" aria-current="page">Physicochemistry and binding</a></li><li class='mega-menu-item mega-menu-item-type-custom mega-menu-item-object-custom mega-current-menu-item mega-menu-item-2468' id='mega-menu-item-2468'><a class="mega-menu-link" href="https://symeres.com/services/admescope-adme-tox/#Permeability_and_transporters" aria-current="page">Permeability and transporters</a></li><li class='mega-menu-item mega-menu-item-type-custom mega-menu-item-object-custom mega-current-menu-item mega-menu-item-2469' id='mega-menu-item-2469'><a class="mega-menu-link" href="https://symeres.com/services/admescope-adme-tox/#In_vitro_metabolism" aria-current="page">In vitro metabolism</a></li><li class='mega-menu-item mega-menu-item-type-custom mega-menu-item-object-custom mega-current-menu-item mega-menu-item-2470' id='mega-menu-item-2470'><a class="mega-menu-link" href="https://symeres.com/services/admescope-adme-tox/#Drug_Interactions" aria-current="page">Drug Interactions</a></li><li class='mega-menu-item mega-menu-item-type-custom mega-menu-item-object-custom mega-current-menu-item mega-menu-item-2471' id='mega-menu-item-2471'><a class="mega-menu-link" href="https://symeres.com/services/admescope-adme-tox/#In_vitro_toxicology" aria-current="page">In vitro toxicology</a></li><li class='mega-menu-item mega-menu-item-type-custom mega-menu-item-object-custom mega-current-menu-item mega-menu-item-2472' id='mega-menu-item-2472'><a class="mega-menu-link" href="https://symeres.com/services/admescope-adme-tox/#In_vivo_drug_metabolism_and_pharmacokinetics" aria-current="page">In vivo drug metabolism and pharmacokinetics</a></li><li class='mega-menu-item mega-menu-item-type-custom mega-menu-item-object-custom mega-current-menu-item mega-menu-item-2473' id='mega-menu-item-2473'><a class="mega-menu-link" href="https://symeres.com/services/admescope-adme-tox/#Safety_metabolism_and_in_vivo_MetID" aria-current="page">Safety metabolism and in vivo MetID</a></li> </ul> </li> </ul> </li> </ul> </li></ul> </li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-has-children mega-align-bottom-left mega-menu-flyout mega-menu-item-301' id='mega-menu-item-301'><a class="mega-menu-link" href="https://symeres.com/whats-new/" aria-expanded="false" tabindex="0">What’s new<span class="mega-indicator"></span></a> <ul class="mega-sub-menu"> <li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-304' id='mega-menu-item-304'><a class="mega-menu-link" href="https://symeres.com/whats-new/news/">News</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-789' id='mega-menu-item-789'><a class="mega-menu-link" href="https://symeres.com/about-us/upcoming-events/">Events</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-302' id='mega-menu-item-302'><a class="mega-menu-link" href="https://symeres.com/whats-new/patents/">Patents</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-303' id='mega-menu-item-303'><a class="mega-menu-link" href="https://symeres.com/whats-new/publications/">Publications</a></li></ul> </li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-has-children mega-align-bottom-left mega-menu-flyout mega-menu-item-1662' id='mega-menu-item-1662'><a class="mega-menu-link" href="https://symeres.com/about-us/" aria-expanded="false" tabindex="0">About us<span class="mega-indicator"></span></a> <ul class="mega-sub-menu"> <li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-1668' id='mega-menu-item-1668'><a class="mega-menu-link" href="https://symeres.com/about-us/why-work-with-us/">Why work with us</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-menu-item-295' id='mega-menu-item-295'><a class="mega-menu-link" href="https://symeres.com/about-us/meet-the-team/">Meet the team</a></li></ul> </li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-align-bottom-left mega-menu-flyout mega-menu-item-300' id='mega-menu-item-300'><a class="mega-menu-link" href="https://symeres.com/vacancies/" tabindex="0">Vacancies</a></li><li class='mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-align-bottom-left mega-menu-flyout mega-menu-item-296' id='mega-menu-item-296'><a class="mega-menu-link" href="https://symeres.com/contact-us/" tabindex="0">Contact us</a></li><li class='mega-header__button mega-menu-item mega-menu-item-type-post_type mega-menu-item-object-page mega-align-bottom-left mega-menu-flyout mega-menu-item-3498 header__button' id='mega-menu-item-3498'><a class="mega-menu-link" href="https://symeres.com/subscribe-to-newsletter/" tabindex="0">Subscribe to newsletter</a></li></ul></div> <div class="wp-block-group header__search is-layout-flow wp-block-group-is-layout-flow"> <div class="search"> <form action="/" method="get" class="search__form"> <input class="search__qry" id="searchright" type="search" name="s" placeholder="Search"> <label class="search__button" for="searchright"> <svg xmlns:xlink="http://www.w3.org/1999/xlink"> <title>Search icon</title> <use xlink:href="#icon-search"></use> </svg> </label> </form> </div>       </div> </div> </header> <div class="hero"> <div class="hero__top" style="background-image: url('https://symeres.com/wp-content/uploads/2023/06/Hero-Image-Adme-1.jpg');"> <div class="hero__content"> <div class="hero__heading"> <svg xmlns:xlink="http://www.w3.org/1999/xlink"><use xlink:href="#icon-services-admetox"></use></svg> <h1>Admescope ADME-Tox</h1> </div> </div> </div> </div> <main class="wp-block-group main main--page is-layout-flow wp-block-group-is-layout-flow"> <div class="wp-block-group main__content is-layout-constrained wp-block-group-is-layout-constrained"> <div id="ez-toc-container" class="ez-toc-v2_0_69_1 counter-flat ez-toc-counter ez-toc-grey ez-toc-container-direction"> <div class="ez-toc-title-container"> <p class="ez-toc-title" style="cursor:inherit">Table of Contents</p> <span class="ez-toc-title-toggle"></span></div> <nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-1" href="#Introduction" title="Introduction">Introduction</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-2" href="#Physicochemistry_and_binding" title="Physicochemistry and binding">Physicochemistry and binding</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-3" href="#Permeability_and_transporters" title="Permeability and transporters">Permeability and transporters</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-4" href="#In_vitro_metabolism" title="In vitro metabolism">In vitro metabolism</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-5" href="#Drug_Interactions" title="Drug Interactions">Drug Interactions</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-6" href="#In_vitro_toxicology" title="In vitro toxicology">In vitro toxicology</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-7" href="#In_vivo_drug_metabolism_and_pharmacokinetics" title="In vivo drug metabolism and pharmacokinetics">In vivo drug metabolism and pharmacokinetics</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-8" href="#Safety_metabolism_and_in_vivo_MetID" title="Safety metabolism and in vivo MetID">Safety metabolism and in vivo MetID</a></li></ul></nav></div> <div class="entry-content wp-block-post-content is-layout-flow wp-block-post-content-is-layout-flow"> <h2 class="wp-block-heading"><span class="ez-toc-section" id="Introduction"></span><strong>Introduction</strong><span class="ez-toc-section-end"></span></h2> <p class="has-medium-font-size"><strong>We can support your pharmaceutical discovery and development programs even further with our Admescope platform of high quality <em>in vitro</em> ADME-Tox profiling platform and<em> in vivo</em> DMPK services.</strong></p> <p class="has-medium-font-size">Our Symeres Admescope platform has an early ADME panel co-located with our medicinal chemistry laboratories in the Netherlands to support our integrated optimization projects.</p> <p class="has-medium-font-size">We have a far larger suite of customizable <em>in vitro</em> ADME-Tox and <em>in vivo</em> DMPK services at our Admescope laboratories in Finland that supports both discovery and development-stage small molecule and biologics projects.</p> <p class="has-medium-font-size">It is crucial to conduct the right studies at the right time to manage costs, for fast decision-making and to reduce the risk for failure at later stages of a project.</p> <h2 class="wp-block-heading"><span class="ez-toc-section" id="Physicochemistry_and_binding"></span>Physicochemistry and binding<span class="ez-toc-section-end"></span></h2> <p class="has-medium-font-size">Physicochemical parameters give information about the “drug-likeness” of the compound, with respect to absorption from the intestine. Information about these properties is also valuable when planning optimum conditions for other <em>in vitro</em> ADME assays.</p> <ul class="wp-block-list"> <li class="has-medium-font-size"><a href="https://www.admescope.com/services/physicochemistry-and-binding/#Lipophilicity_logPD">Lipophilicity</a> (shake flask method and RP-HPLC screening method)</li> <li class="has-medium-font-size"><a href="https://www.admescope.com/services/physicochemistry-and-binding/#Solubility">Solubility</a></li> <li class="has-medium-font-size"><a href="https://www.admescope.com/services/physicochemistry-and-binding/#Stability_in_Plasma_Buffer_or_Biorelevant_Media">Stability in plasma, buffer or biorelevant media</a></li> <li class="has-medium-font-size"><a href="https://www.admescope.com/services/physicochemistry-and-binding/#Plasma_Protein_Binding">Plasma protein binding</a></li> <li class="has-medium-font-size"><a href="https://www.admescope.com/services/physicochemistry-and-binding/#Red_Blood_Cell_Binding">Red blood cell binding</a></li> <li class="has-medium-font-size"><a href="https://www.admescope.com/services/physicochemistry-and-binding/#Tissue_Binding">Tissue binding</a></li> <li class="has-medium-font-size"><a href="https://www.admescope.com/services/physicochemistry-and-binding/#Microsome_Hepatocyte_Binding">Microsome/Hepatocyte binding</a></li> </ul> <div style="height:10px" aria-hidden="true" class="wp-block-spacer"></div> <div style="height:30px" aria-hidden="true" class="wp-block-spacer"></div> <hr class="wp-block-separator has-alpha-channel-opacity is-style-wide" /> <h2 class="wp-block-heading"><span class="ez-toc-section" id="Permeability_and_transporters"></span>Permeability and transporters<span class="ez-toc-section-end"></span></h2> <p class="has-medium-font-size">Several assays are available for evaluating permeability and identifying drug transporter substrates or inhibitors.</p> <ul class="wp-block-list"> <li class="has-medium-font-size"><a href="https://www.admescope.com/services/permeability-and-transporters/#Parallel_Artificial_Membrane_Permeability_Assay_PAMPA">PAMPA (parallel artificial membrane permeability assay)</a></li> <li class="has-medium-font-size"><a href="https://www.admescope.com/services/permeability-and-transporters/#Caco-2_MDCK_Permeability">Caco-2/MDCK permeability</a></li> <li class="has-medium-font-size"><a href="https://www.admescope.com/services/permeability-and-transporters/#Efflux_Transporters">Efflux transporters</a></li> <li class="has-medium-font-size"><a href="https://www.admescope.com/services/permeability-and-transporters/#Uptake_Transporters">Uptake transporters</a></li> </ul> <div style="height:10px" aria-hidden="true" class="wp-block-spacer"></div> <div style="height:30px" aria-hidden="true" class="wp-block-spacer"></div> <hr class="wp-block-separator has-alpha-channel-opacity is-style-wide" /> <h2 class="wp-block-heading"><span class="ez-toc-section" id="In_vitro_metabolism"></span><em>In vitro</em> metabolism<span class="ez-toc-section-end"></span></h2> <figure class="wp-block-image alignright size-full"><img decoding="async" width="337" height="386" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%20337%20386'%3E%3C/svg%3E" alt="" class="wp-image-3411" data-lazy-srcset="https://symeres.com/wp-content/uploads/2023/06/in-vitro-metabolism-4.png 337w, https://symeres.com/wp-content/uploads/2023/06/in-vitro-metabolism-4-262x300.png 262w" data-lazy-sizes="(max-width: 337px) 100vw, 337px" data-lazy-src="https://symeres.com/wp-content/uploads/2023/06/in-vitro-metabolism-4.png" /><noscript><img decoding="async" width="337" height="386" src="https://symeres.com/wp-content/uploads/2023/06/in-vitro-metabolism-4.png" alt="" class="wp-image-3411" srcset="https://symeres.com/wp-content/uploads/2023/06/in-vitro-metabolism-4.png 337w, https://symeres.com/wp-content/uploads/2023/06/in-vitro-metabolism-4-262x300.png 262w" sizes="(max-width: 337px) 100vw, 337px" /></noscript></figure> <p class="has-medium-font-size">High-quality <em>in vitro</em> metabolism services are available to evaluate the metabolic fate of the compound in liver or extrahepatic tissues. The samples are analysed with state-of-the-art UPLC/HR-MS equipment.</p> <ul class="wp-block-list"> <li class="has-medium-font-size"><a href="https://www.admescope.com/services/in-vitro-metabolism/#Metabolic_Stability">Metabolic stability</a></li> <li class="has-medium-font-size"><a href="https://www.admescope.com/services/in-vitro-metabolism/#Metabolite_Identification_and_Profiling">Metabolite identification and profiling</a></li> <li class="has-medium-font-size"><a href="https://symeres.com/services/synthetic-chemistry/">Metabolite synthesis</a></li> <li class="has-medium-font-size"><a href="https://www.admescope.com/services/in-vitro-metabolism/#Phenotyping_of_Metabolizing_Enzymes">Identification of metabolising enzymes</a></li> <li class="has-medium-font-size"><a href="https://www.admescope.com/services/in-vitro-metabolism/#Non-CYP_Mediated_Metabolism">Non-CYP mediated metabolism</a></li> <li class="has-medium-font-size"><a href="https://www.admescope.com/services/in-vitro-metabolism/#Extrahepatic_Metabolism">Extrahepatic metabolism</a></li> <li class="has-medium-font-size"><a href="https://www.admescope.com/services/in-vitro-metabolism/#Metabolite_Production">Metabolite production and NMR identification</a></li> <li class="has-medium-font-size"><a href="https://www.admescope.com/services/in-vitro-metabolism/#Reactive_Metabolite_Screening">Reactive metabolite screening</a></li> <li class="has-medium-font-size"><a href="https://www.admescope.com/services/in-vitro-metabolism/#Acyl-Glucuronide_Reactivity">Acyl-Glucuronide reactivity</a></li> </ul> <div style="height:10px" aria-hidden="true" class="wp-block-spacer"></div> <div style="height:30px" aria-hidden="true" class="wp-block-spacer"></div> <hr class="wp-block-separator has-alpha-channel-opacity is-style-wide" /> <h2 class="wp-block-heading"><span class="ez-toc-section" id="Drug_Interactions"></span>Drug Interactions<span class="ez-toc-section-end"></span></h2> <p class="has-medium-font-size">Evaluating drug-drug interaction risk is a crucial part of drug safety evaluation required by the drug regulatory authorities. The available services cover the <a href="https://www.admescope.com/in-vitro-metabolism/identification-of-metabolising-enzymes.html">identification of metabolising enzymes</a>, enzyme inhibition and enzyme induction assays, as well as transporter-mediated drug-drug interactions.</p> <ul class="wp-block-list"> <li class="has-medium-font-size"><a href="https://www.admescope.com/services/drug-interactions/#CYP_Inhibition">CYP inhibition</a></li> <li class="has-medium-font-size"><a href="https://www.admescope.com/services/drug-interactions/#UGT_Inhibition">UGT inhibition</a></li> <li class="has-medium-font-size"><a href="https://www.admescope.com/services/drug-interactions/#Inhibition_towards_other_Metabolising_Enzymes">Inhibition towards other metabolising enzymes</a></li> <li class="has-medium-font-size"><a href="https://www.admescope.com/services/drug-interactions/#CYP_Induction">CYP induction</a></li> <li class="has-medium-font-size"><a href="https://www.admescope.com/services/drug-interactions/#UGT_Induction">UGT induction</a></li> <li class="has-medium-font-size"><a href="https://www.admescope.com/services/drug-interactions/#Transporter_Interactions">Transporter interactions</a></li> </ul> <figure class="wp-block-image size-full is-resized"><img decoding="async" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%20340%20391'%3E%3C/svg%3E" alt="" class="wp-image-3391" width="340" height="391" data-lazy-srcset="https://symeres.com/wp-content/uploads/2023/06/Drug-interactions-Adme.jpg 336w, https://symeres.com/wp-content/uploads/2023/06/Drug-interactions-Adme-261x300.jpg 261w" data-lazy-sizes="(max-width: 340px) 100vw, 340px" data-lazy-src="https://symeres.com/wp-content/uploads/2023/06/Drug-interactions-Adme.jpg" /><noscript><img decoding="async" src="https://symeres.com/wp-content/uploads/2023/06/Drug-interactions-Adme.jpg" alt="" class="wp-image-3391" width="340" height="391" srcset="https://symeres.com/wp-content/uploads/2023/06/Drug-interactions-Adme.jpg 336w, https://symeres.com/wp-content/uploads/2023/06/Drug-interactions-Adme-261x300.jpg 261w" sizes="(max-width: 340px) 100vw, 340px" /></noscript></figure> <p class="has-medium-font-size"></p> <div style="height:10px" aria-hidden="true" class="wp-block-spacer"></div> <div style="height:30px" aria-hidden="true" class="wp-block-spacer"></div> <hr class="wp-block-separator has-alpha-channel-opacity is-style-wide" /> <h2 class="wp-block-heading"><span class="ez-toc-section" id="In_vitro_toxicology"></span><em>In vitro</em> toxicology<span class="ez-toc-section-end"></span></h2> <p class="has-medium-font-size">Information about <em>in vitro</em> toxicity early on during the drug discovery process support your internal decision making. The available non-GLP <em>in vitro</em> toxicology assays are planned for cost-efficient screening with low compound consumption and cover the most commonly faced toxicity related challenges.</p> <ul class="wp-block-list"> <li class="has-medium-font-size"><a href="https://www.admescope.com/services/in-vitro-toxicology/#Cardiotoxicity_Screening">Cardiotoxicity screening</a></li> <li class="has-medium-font-size"><a href="https://www.admescope.com/services/in-vitro-toxicology/#Cardiotoxicity_Screening">hERG Predictor fluorescence polarisation assay</a></li> <li class="has-medium-font-size">Electrophysiology (via our partner <a href="https://axxam.com/" target="_blank" rel="noreferrer noopener">Axxam</a>)</li> <li class="has-medium-font-size"><a href="https://www.admescope.com/services/in-vitro-toxicology/#Genotoxicity_Screening">Genotoxicity screening</a></li> <li class="has-medium-font-size"><a href="https://www.admescope.com/services/in-vitro-toxicology/#Cytotoxicity_Screening">Cytotoxicity screening</a></li> <li class="has-medium-font-size"><a href="https://www.admescope.com/services/in-vitro-toxicology/#Mechanistic_Toxicity_Assays">Mechanistic toxicity assays</a></li> <li class="has-medium-font-size"><a href="https://www.admescope.com/services/in-vitro-toxicology/#Hematologic_toxicology">Hematologic toxicity</a></li> <li class="has-medium-font-size"><a href="https://admescope.com/services/in-vitro-toxicology/#Hepatotoxicity_screening">Hepatoxicity and drug induced liver injury assessment</a></li> </ul> <div style="height:10px" aria-hidden="true" class="wp-block-spacer"></div> <div style="height:30px" aria-hidden="true" class="wp-block-spacer"></div> <hr class="wp-block-separator has-alpha-channel-opacity is-style-wide" /> <h2 class="wp-block-heading"><span class="ez-toc-section" id="In_vivo_drug_metabolism_and_pharmacokinetics"></span><em>In vivo</em> drug metabolism and pharmacokinetics<span class="ez-toc-section-end"></span></h2> <figure class="wp-block-image alignright size-full"><img decoding="async" width="336" height="386" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%20336%20386'%3E%3C/svg%3E" alt="" class="wp-image-2307" data-lazy-srcset="https://symeres.com/wp-content/uploads/2023/05/adme-tox-2.png 336w, https://symeres.com/wp-content/uploads/2023/05/adme-tox-2-261x300.png 261w" data-lazy-sizes="(max-width: 336px) 100vw, 336px" data-lazy-src="https://symeres.com/wp-content/uploads/2023/05/adme-tox-2.png" /><noscript><img decoding="async" width="336" height="386" src="https://symeres.com/wp-content/uploads/2023/05/adme-tox-2.png" alt="" class="wp-image-2307" srcset="https://symeres.com/wp-content/uploads/2023/05/adme-tox-2.png 336w, https://symeres.com/wp-content/uploads/2023/05/adme-tox-2-261x300.png 261w" sizes="(max-width: 336px) 100vw, 336px" /></noscript></figure> <ul class="wp-block-list"> <li class="has-medium-font-size">The <a href="https://www.admescope.com/services/in-vivo-dmpk/"><em>in vivo</em> DMPK services</a> cover a variety of animal experiments in several species. In-house rodent PK studies are carried out in AAALAC accredited animal facilities and studies with other species are completed together with selected European in-life partners.</li> <li class="has-medium-font-size"><a href="https://www.admescope.com/services/in-vivo-dmpk/#Animal_Pharmacokinetics">Animal pharmacokinetics</a></li> <li class="has-medium-font-size"><a href="https://www.admescope.com/services/in-vitro-metabolism/#Metabolite_Identification_and_Profiling"><em>In vivo</em> MetID</a></li> </ul> <div style="height:10px" aria-hidden="true" class="wp-block-spacer"></div> <div style="height:30px" aria-hidden="true" class="wp-block-spacer"></div> <hr class="wp-block-separator has-alpha-channel-opacity is-style-wide" /> <h2 class="wp-block-heading" id="anchor"><span class="ez-toc-section" id="Safety_metabolism_and_in_vivo_MetID"></span>Safety metabolism and <em>in vivo</em> MetID<span class="ez-toc-section-end"></span></h2> <p class="has-medium-font-size"><a href="https://www.admescope.com/services/safety-metabolism/">Safety metabolism</a> studies help you to confirm that the exposure to human metabolites is adequate in preclinical safety species, or to effectively identify potential MIST (metabolites in safety testing) issues in time, through a battery of different types of <em>in vivo</em> MetID studies.</p> <ul class="wp-block-list"> <li class="has-medium-font-size">Metabolite profiling and characterisation in pre-clinical species</li> <li class="has-medium-font-size">Human metabolite profiling and characterisation (FIM, SAD, MAD)</li> <li class="has-medium-font-size">Human MIST analysis (MAD + preclinical safety species)</li> <li class="has-medium-font-size">Metabolite profiling and characterisation in radiolabelled human ADME study</li> <li class="has-medium-font-size">Metabolite profiling in milk secretion studies</li> </ul> <div style="height:47px" aria-hidden="true" class="wp-block-spacer"></div> </div></div> <section class="block block--primary"> <div class="block__content block__content--right"> <div class="block__text"> <h2>Feel free to contact us!</h2> <p><strong>Curious to know more about what can we do for you? Get in touch and let’s start a conversation.</strong></p> <p><a href="/contact-us/" class="button">Contact us</a></p> </div> <figure class="block__figure"> <img width="430" height="525" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%20430%20525'%3E%3C/svg%3E" alt data-lazy-src="https://symeres.com/wp-content/themes/symeres-2023/dist/img/contact-image-primary.png"><noscript><img width="430" height="525" src="https://symeres.com/wp-content/themes/symeres-2023/dist/img/contact-image-primary.png" alt></noscript> </figure> </div> </section></main> <footer class="footer wp-block-template-part"> <div class="wp-block-group footer__top is-layout-flow wp-block-group-is-layout-flow"> <div class="wp-block-group footer__content footer__content--logo is-layout-flow wp-block-group-is-layout-flow"> <figure class="wp-block-image size-large footer__logo"> <a href="https://symeres.com" title="Symeres.com"> <img width="339" height="97" decoding="async" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%20339%2097'%3E%3C/svg%3E" alt="" class="wp-image-44" data-lazy-src="https://symeres.com/wp-content/uploads/2022/12/symeres-logo-web-white.svg"><noscript><img width="339" height="97" decoding="async" src="https://symeres.com/wp-content/uploads/2022/12/symeres-logo-web-white.svg" alt="" class="wp-image-44"></noscript> </a> </figure> </div> <div class="wp-block-group footer__content is-layout-flow wp-block-group-is-layout-flow"> <div class="wp-block-group footer__block is-layout-flow wp-block-group-is-layout-flow"><h4>Contact</h4> <ul> <li><a href="tel:+31243723300">+31 (0)24 372 33 00</a></li> <li><a href="mailto:info@symeres.com">info@symeres.com</a></li> </ul> </div> <div class="wp-block-group footer__block is-layout-flow wp-block-group-is-layout-flow"><h4>Customer Service</h4> <ul> <li><a href="https://symeres.com/about-us/">About us</a></li> <li><a href="https://symeres.com/about-us/meet-the-team/">Meet our team</a></li> <li><a href="https://symeres.com/contact-us/">Our facilities</a></li> </ul> </div> <div class="wp-block-group footer__block is-layout-flow wp-block-group-is-layout-flow"><h4>Information</h4> <ul> <li><a href="https://symeres.com/vacancies/">Jobs at Symeres</a></li> <li><a href="https://symeres.com/privacy-policy/">Privacy Policy</a></li> <li><a href="https://symeres.com/cookies/">Cookies</a></li> </ul> </div> <div class="wp-block-group footer__block footer__block--social is-layout-flow wp-block-group-is-layout-flow"> <h4 class="wp-block-heading">Stay up-to-date by following us on social media</h4> <ul> <li> <a href="https://www.linkedin.com/company/symeresbv/"> <svg xmlns:xlink="http://www.w3.org/1999/xlink"> <title>Follow Symeres on LinkedIn</title> <use xlink:href="#icon-linkedin"></use> </svg> </a> </li> <li> <a href="https://www.youtube.com/@symeres809"> <svg xmlns:xlink="http://www.w3.org/1999/xlink"> <title>Follow Symeres on YouTube</title> <use xlink:href="#icon-youtube"></use> </svg> </a> </li> <ul> </div> </div> </div> <div class="wp-block-group footer__bottom is-layout-flow wp-block-group-is-layout-flow"> <div class="wp-block-group footer__content footer__content--bottom is-layout-flow wp-block-group-is-layout-flow"> <div class="wp-block-group footer__block is-layout-flow wp-block-group-is-layout-flow"> <p>Symeres @2023</p> </div> </div> </div> </footer> <div class="svgsprite wp-block-template-part"> <div class="svg"> <svg xmlns="http://www.w3.org/2000/svg" width="0" height="0" viewBox="0 0 100 100"> <defs> <clipPath id="hexagon" clipPathUnits="objectBoundingBox"> <path d="M0.97,0.231,0.53,0.007 a0.06,0.053,0,0,0,-0.06,0 L0.03,0.231 A0.06,0.053,0,0,0,0,0.276 v0.447 a0.06,0.053,0,0,0,0.03,0.046 l0.44,0.224 a0.06,0.053,0,0,0,0.06,0 l0.44,-0.224 A0.06,0.053,0,0,0,1,0.724 V0.276 a0.06,0.053,0,0,0,-0.03,-0.046"/> </clipPath> </defs>  <symbol id="icon-services-admetox" viewBox="0 0 36 36"> <g fill="currentColor" fill-rule="nonzero"><path d="M16.239 19.136a.664.664 0 0 1-.573-.327l-1.71-2.917a.655.655 0 0 1 .234-.898.664.664 0 0 1 .905.235l1.71 2.916a.654.654 0 0 1-.566.99M7.968 19.354a.659.659 0 0 1-.573-.985l1.847-3.188a.664.664 0 0 1 1.213.156.654.654 0 0 1-.065.5l-1.847 3.187a.664.664 0 0 1-.574.33M14.113 23.615h-.004l-3.752-.02a.657.657 0 0 1 .004-1.314l3.753.02a.657.657 0 0 1-.004 1.314"/><path d="m14.63 24.543-5.644-.032-3.139-5.47 3.203-5.433 6.339.036 3.139 5.47-.006.009c.442-.149.9-.243 1.365-.28-.007-.017-.01-.035-.02-.05l-3.516-6.132a.663.663 0 0 0-.572-.331l-7.103-.04h-.004a.664.664 0 0 0-.572.325l-3.588 6.09a.653.653 0 0 0-.004.657l3.518 6.128c.118.204.335.33.57.331l6.035.035v-1.313ZM23.468 18.72a4.04 4.04 0 1 0-4.07-4.04 4.055 4.055 0 0 0 4.07 4.04"/><path d="m31.896 25.772-.02.07-.045.058-.428.245v-1.643a4.576 4.576 0 0 0-4.594-4.56h-6.451a4.576 4.576 0 0 0-4.593 4.56v8.427L3.518 25.912l-.044-.044-.038-.07V9.636l.026-.078.05-.052 14.049-8.05.107-.032.118.038 14.024 8.04.057.057.026.064.003 16.148Zm-3.27 1.964-.576.33V24.91a.288.288 0 0 1 .576 0v2.826ZM18.59 24.91a.288.288 0 0 1 .576 0v8.245l-.572.328c0-3.048-.004-8.574-.004-8.574Zm14.557-16a1.71 1.71 0 0 0-.502-.57L18.364.157A1.53 1.53 0 0 0 17.659 0a1.514 1.514 0 0 0-.711.167L2.748 8.31c-.227.13-.41.324-.528.557-.137.219-.211.47-.214.729L2 25.826c.01.255.084.504.214.724.123.218.295.406.501.548l14.233 8.156c.222.109.467.163.714.157.248.005.494-.049.718-.157l14.239-8.16c.4-.277.658-.714.709-1.197V9.589a1.48 1.48 0 0 0-.183-.678l.003-.001Z"/></g> </symbol> <symbol id="icon-services-drugdevelopment" viewBox="0 0 36 36"> <g fill="currentColor" fill-rule="nonzero"><path d="M17.646 35.4c-.45 0-.893-.12-1.283-.345L3.282 27.49A2.575 2.575 0 0 1 2 25.267V10.134a2.576 2.576 0 0 1 1.282-2.223L16.363.344a2.563 2.563 0 0 1 2.566 0l13.08 7.567a2.576 2.576 0 0 1 1.282 2.223v15.132a2.576 2.576 0 0 1-1.281 2.223l-13.081 7.566c-.39.226-.833.345-1.283.345Zm0-33.835a.998.998 0 0 0-.5.134L4.067 9.267c-.31.18-.5.51-.5.869v15.132c0 .358.19.688.5.868l13.08 7.566a.998.998 0 0 0 1 0l13.08-7.566c.31-.18.5-.511.5-.869V10.134c0-.358-.19-.689-.5-.869L18.146 1.7a.998.998 0 0 0-.5-.134Z"/><path d="M17.165 25.793v-3.298l2.855-1.649 2.857 1.649v3.297l-2.856 1.649-2.856-1.648Zm-9.025-5.21v-3.298l2.855-1.643 2.858 1.643v3.298l-2.857 1.65-2.856-1.65Zm9.67-5.713v-3.3l2.856-1.648 2.855 1.649v3.296l-2.855 1.65-2.856-1.647Zm3.37-8.34-1.236.048.09 2.281-3.46 1.997v3.962l-2.16 1.365-2.937-1.695-.087-2.201-1.235.048.09 2.308-3.341 1.93v3.948l-1.785 1.03.618 1.07 1.73-.998 3.527 2.035 3.475-2.005 1.46.842v4.013l4.092 2.36 3.757-2.165 1.702.982.618-1.072-1.98-1.142v-3.69l-4.094-2.361-3.48 2.005-1.457-.842v-3.366l2.063-1.303 3.514 2.03 3.267-1.888 1.89 1.091.618-1.071-1.677-.97v-3.431l1.932-1.116-.62-1.071-1.843 1.063-2.96-1.708-.09-2.314Z"/></g> </symbol> <symbol id="icon-services-drugdiscovery" viewBox="0 0 36 36"> <g fill="currentColor" fill-rule="nonzero"><path d="M17.646 35.4c-.45 0-.893-.12-1.283-.345L3.282 27.49A2.575 2.575 0 0 1 2 25.267V10.134a2.576 2.576 0 0 1 1.282-2.223L16.363.344a2.563 2.563 0 0 1 2.566 0l13.08 7.567a2.576 2.576 0 0 1 1.282 2.223v15.132a2.576 2.576 0 0 1-1.281 2.223l-13.081 7.566c-.39.226-.833.345-1.283.345Zm0-33.835a.998.998 0 0 0-.5.134L4.067 9.267c-.31.18-.5.51-.5.869v15.132c0 .358.19.688.5.868l13.08 7.566a.998.998 0 0 0 1 0l13.08-7.566c.31-.18.5-.511.5-.869V10.134c0-.358-.19-.689-.5-.869L18.146 1.7a.998.998 0 0 0-.5-.134Z"/><path d="m25.676 25.274-4.868-4.868a6.983 6.983 0 1 0-1.322 1.218l4.92 4.918 1.27-1.268Zm-4.626-9.392a5.607 5.607 0 1 1-5.607-5.61 5.62 5.62 0 0 1 5.606 5.608l.001.002Z"/></g> </symbol> <symbol id="icon-services-syntheticchemistry" viewBox="0 0 36 36"> <g fill="currentColor" fill-rule="nonzero"><path d="m24.469 21.63-4.404-6.401a2.302 2.302 0 0 1-.407-1.31v-3.916a.77.77 0 1 0 0-1.54h-4.617a.77.77 0 1 0 0 1.54v3.917c0 .468-.142.924-.406 1.31l-4.411 6.41a3.393 3.393 0 0 0-.568 2.092c.109 1.918 1.8 3.209 4.208 3.209h7.656a3.47 3.47 0 0 0 3.522-3.21 3.402 3.402 0 0 0-.573-2.1M18.357 19.1l-.063-.032c-.6-.28-1.292-.28-1.892 0l-.061.032a4.226 4.226 0 0 1-2.505 0l2.065-2.997c.443-.641.68-1.402.679-2.182v-3.917h1.54v3.917c-.002.78.235 1.54.677 2.182l2.063 3.003a4.22 4.22 0 0 1-2.504-.004"/><path d="M17.646 35.4c-.45 0-.893-.12-1.283-.345L3.282 27.49A2.575 2.575 0 0 1 2 25.267V10.134a2.576 2.576 0 0 1 1.282-2.223L16.363.344a2.563 2.563 0 0 1 2.566 0l13.08 7.567a2.576 2.576 0 0 1 1.282 2.223v15.132a2.576 2.576 0 0 1-1.281 2.223l-13.081 7.566c-.39.226-.833.345-1.283.345Zm0-33.835a.998.998 0 0 0-.5.134L4.067 9.267c-.31.18-.5.51-.5.869v15.132c0 .358.19.688.5.868l13.08 7.566a.998.998 0 0 0 1 0l13.08-7.566c.31-.18.5-.511.5-.869V10.134c0-.358-.19-.689-.5-.869L18.146 1.7a.998.998 0 0 0-.5-.134Z"/></g> </symbol>  <symbol id="icon-services-invitrometabolism" viewBox="0 0 36 36"> <g fill="currentColor" fill-rule="nonzero"> <path d="M16.544.375c.864-.5 1.928-.5 2.792 0L32.48 7.977l.158.099a2.799 2.799 0 0 1 1.235 2.134l.006.187v15.209a2.798 2.798 0 0 1-1.398 2.416l-13.146 7.604c-.864.499-1.928.499-2.792 0L3.4 28.023A2.799 2.799 0 0 1 2 25.604v-15.21a2.798 2.798 0 0 1 1.398-2.416L16.544.375Zm14.937 9.333L18.335 2.105a.788.788 0 0 0-.79 0L4.398 9.708a.799.799 0 0 0-.4.689v15.205a.8.8 0 0 0 .4.69l13.147 7.603a.79.79 0 0 0 .79 0l13.147-7.603a.799.799 0 0 0 .4-.689V10.4a.8.8 0 0 0-.4-.69l.222-.386-.223.385Z"/><path d="M23.177 9.43a.65.65 0 0 1 .589.647.76.76 0 0 1-.589.721h-1.413v12.93a3.86 3.86 0 0 1-3.772 3.606h-.2a3.505 3.505 0 0 1-3.677-3.605v-12.93h-1.383a.628.628 0 0 1-.618-.685.665.665 0 0 1 .677-.684h10.386Zm-2.647 1.368h-5.18l.001 8.944h5.18l-.001-8.944Z"/> </g> </symbol> <symbol id="icon-services-safetymetabolism" viewBox="0 0 36 36"> <g fill="currentColor" fill-rule="nonzero"> <path d="M31.48 9.708 18.335 2.105a.788.788 0 0 0-.79 0L4.398 9.708a.799.799 0 0 0-.4.689v15.205a.8.8 0 0 0 .4.69l13.147 7.603a.79.79 0 0 0 .79 0l13.147-7.603a.799.799 0 0 0 .4-.689V10.4a.8.8 0 0 0-.4-.69l.88-1.526-.882 1.525Zm1.16-1.632a2.8 2.8 0 0 1 1.24 2.32v15.21a2.798 2.798 0 0 1-1.398 2.416l-13.146 7.604c-.864.499-1.928.499-2.792 0L3.4 28.023A2.799 2.799 0 0 1 2 25.604v-15.21a2.798 2.798 0 0 1 1.398-2.416L16.544.375c.864-.5 1.928-.5 2.792 0L32.48 7.978l.158.098Z"/><path d="M26.79 16.12a3.712 3.712 0 1 1-3.712-3.683 3.697 3.697 0 0 1 3.711 3.682M30.189 27.906V24.95A4.172 4.172 0 0 0 26 20.794h-5.883a4.173 4.173 0 0 0-4.188 4.156v9.012l1.768 1.012.092.026.085-.026.637-.364v-9.293a.263.263 0 1 1 .525 0v8.648l8.1-4.638v-4.008a.263.263 0 0 1 .526 0v4.037l2.527-1.45ZM16.468 20.223a.6.6 0 0 1-.52-.3l-1.552-2.641a.6.6 0 0 1 1.039-.6l1.552 2.645a.6.6 0 0 1-.518.896M8.959 20.422a.6.6 0 0 1-.295-.084.594.594 0 0 1-.222-.814l1.673-2.888a.6.6 0 0 1 .82-.22.594.594 0 0 1 .222.815L9.48 20.122a.6.6 0 0 1-.521.3M14.538 24.288l-3.407-.019a.6.6 0 1 1 0-1.192l3.407.02a.6.6 0 1 1 0 1.191"/><path d="m15.006 25.13-5.124-.03-2.845-4.962 2.898-4.929 5.757.033 2.85 4.962-.005.01c.4-.136.817-.221 1.239-.255-.007-.015-.01-.03-.018-.044l-3.198-5.561a.6.6 0 0 0-.519-.3l-6.44-.039a.6.6 0 0 0-.52.3l-3.26 5.519a.593.593 0 0 0 0 .6l3.197 5.56a.6.6 0 0 0 .518.299l5.478.032-.008-1.195Z"/> </g> </symbol> <symbol id="icon-services-invivodmpk" viewBox="0 0 36 36"> <g fill="currentColor" fill-rule="nonzero"> <path d="M31.502 9.715 18.347 2.106a.79.79 0 0 0-.79 0L4.4 9.716a.8.8 0 0 0-.4.689V25.62a.8.8 0 0 0 .4.69l13.157 7.61a.79.79 0 0 0 .79 0l13.157-7.61a.8.8 0 0 0 .4-.688V10.407a.8.8 0 0 0-.4-.691l.88-1.527-.882 1.526Zm1.16-1.633a2.801 2.801 0 0 1 1.242 2.323v15.22a2.8 2.8 0 0 1-1.4 2.418l-13.155 7.61c-.864.499-1.93.499-2.794 0L3.4 28.042a2.801 2.801 0 0 1-1.4-2.42v-15.22a2.8 2.8 0 0 1 1.4-2.42L16.554.376c.864-.5 1.93-.5 2.794 0l13.155 7.609.158.098Z"/><path d="M17.933 10.842c7.656 0 9.892 5.363 9.669 8.537a5.451 5.451 0 0 1-1.454 3.6 5.678 5.678 0 0 1-4.135 1.5.6.6 0 0 1-.615-.665c0-.693.559-.665.559-.665a4.781 4.781 0 0 0 3.13-1.053 4.392 4.392 0 0 0 1.118-2.606l-17.569.01a.229.229 0 0 1-.229-.093.732.732 0 0 1-.123-.49c0-3.252 2.686-8.075 9.649-8.075Zm-5.711 4.108a1.255 1.255 0 1 0 .006 2.51 1.255 1.255 0 0 0-.006-2.51Z"/> </g> </symbol> <symbol id="icon-services-druginteractions" viewBox="0 0 36 36"> <g fill="currentColor" fill-rule="nonzero"> <path d="M16.561.368a2.74 2.74 0 0 1 2.745 0l13.185 7.627a2.75 2.75 0 0 1 1.37 2.195l.007.184v15.255a2.751 2.751 0 0 1-1.376 2.376l-13.186 7.627c-.849.49-1.895.49-2.745 0L3.376 28.006A2.753 2.753 0 0 1 2 25.628V10.372a2.751 2.751 0 0 1 1.375-2.377L16.561.368Zm14.982 9.267L18.357 2.008a.846.846 0 0 0-.847 0L4.323 9.636a.856.856 0 0 0-.428.739v15.251c0 .305.164.587.429.74l13.186 7.627a.847.847 0 0 0 .848 0l13.186-7.627a.856.856 0 0 0 .429-.738V10.376a.857.857 0 0 0-.429-.74l.183-.319-.184.318Z"/><path d="M17.919 13.818a4.31 4.31 0 0 1 2.555 4.233 4.61 4.61 0 0 1-2.555 4.374 4.673 4.673 0 0 1-2.521-4.304 4.674 4.674 0 0 1 2.52-4.303"/><path d="M13.751 23.69c2.743 0 3.181-.996 3.181-.996a4.873 4.873 0 0 1-2.491-4.572 5.2 5.2 0 0 1 2.636-4.71s-.72-1.103-3.326-1.103A5.658 5.658 0 0 0 8.126 18a5.658 5.658 0 0 0 5.625 5.69M22.114 23.69c-2.743 0-3.18-.996-3.18-.996a4.873 4.873 0 0 0 2.495-4.572 5.2 5.2 0 0 0-2.636-4.71s.715-1.103 3.321-1.103A5.658 5.658 0 0 1 27.74 18a5.658 5.658 0 0 1-5.625 5.69"/> </g> </symbol> <symbol id="icon-services-quantitativeanalysis" viewBox="0 0 36 36"> <g fill="currentColor" fill-rule="nonzero"> <path d="M16.561.368a2.74 2.74 0 0 1 2.745 0l13.185 7.627a2.75 2.75 0 0 1 1.37 2.195l.007.184v15.255a2.751 2.751 0 0 1-1.376 2.376l-13.186 7.627c-.849.49-1.895.49-2.745 0L3.376 28.006A2.753 2.753 0 0 1 2 25.628V10.372a2.751 2.751 0 0 1 1.375-2.377L16.561.368Zm14.982 9.267L18.357 2.008a.846.846 0 0 0-.847 0L4.323 9.636a.856.856 0 0 0-.428.739v15.251c0 .305.164.587.429.74l13.186 7.627a.847.847 0 0 0 .848 0l13.186-7.627a.856.856 0 0 0 .429-.738V10.376a.857.857 0 0 0-.429-.74l.183-.319-.184.318Z"/><path d="M8.705 9.229V25.9a.79.79 0 0 0 .849.787.792.792 0 0 0 .848-.787V9.23a.837.837 0 0 0-.848-.788c-.637 0-.85.788-.85.788M10.968 13.523v12.45a.792.792 0 0 0 .849.788.792.792 0 0 0 .849-.788v-12.45a.836.836 0 0 0-.85-.788c-.637 0-.85.788-.85.788M13.231 24.113v1.86a.792.792 0 0 0 .849.788.792.792 0 0 0 .847-.788v-1.932a.794.794 0 0 0-.85-.716c-.636 0-.848.788-.848.788M19.349 24.113v1.86a.851.851 0 0 0 1.698 0V24.16a.819.819 0 0 0-.849-.83.792.792 0 0 0-.849.788M21.647 16.327v9.585a.851.851 0 0 0 1.697 0v-9.585a.851.851 0 0 0-1.697 0M26.245 16.17v9.745a.851.851 0 0 0 1.697 0v-9.788a.81.81 0 0 0-.85-.816.838.838 0 0 0-.848.859M23.947 18.462v7.517a.851.851 0 0 0 1.696 0v-7.517a.85.85 0 1 0-1.696 0M15.494 21.322v4.65a.792.792 0 0 0 .85.788.792.792 0 0 0 .848-.788v-4.65a.756.756 0 0 0-.849-.644.95.95 0 0 0-.849.644"/> </g> </symbol> <symbol id="icon-services-permeability&transporters" viewBox="0 0 36 36"> <g fill="none" fill-rule="evenodd"> <path fill="currentColor" fill-rule="nonzero" d="M16.561.368a2.74 2.74 0 0 1 2.745 0l13.185 7.627a2.75 2.75 0 0 1 1.37 2.195l.007.184v15.254a2.751 2.751 0 0 1-1.376 2.376l-4.103 2.374-9.083 5.254c-.849.49-1.895.49-2.745 0L3.376 28.006A2.753 2.753 0 0 1 2 25.628V10.372a2.751 2.751 0 0 1 1.375-2.377L16.561.368Zm14.982 9.267L18.357 2.008a.846.846 0 0 0-.847 0L4.323 9.636a.856.856 0 0 0-.428.739v15.251c0 .305.164.587.429.74l13.186 7.627a.847.847 0 0 0 .847 0l9.083-5.254 4.104-2.374a.856.856 0 0 0 .429-.738v-15.25a.857.857 0 0 0-.429-.74l.183-.319-.184.318Z"/><path stroke="currentColor" stroke-linecap="round" stroke-width="2" d="M17.484 8.572v19.829"/><path fill="currentColor" fill-rule="nonzero" d="M10.872 14.07a1.547 1.547 0 0 0 1.543-1.55c0-.854-.69-1.546-1.543-1.548a1.547 1.547 0 0 0-1.544 1.55c0 .853.69 1.545 1.544 1.547M13.11 19.957a1.547 1.547 0 0 0 1.543-1.55c0-.853-.69-1.546-1.543-1.548a1.547 1.547 0 0 0-1.544 1.55c0 .853.69 1.546 1.544 1.548M10.872 25.844a1.547 1.547 0 0 0 1.543-1.55c0-.853-.69-1.545-1.543-1.547a1.547 1.547 0 0 0-1.544 1.55c0 .853.69 1.545 1.544 1.547M22.99 16.626a1.547 1.547 0 0 0 1.543-1.55c0-.853-.69-1.546-1.544-1.547a1.547 1.547 0 0 0-1.543 1.55c0 .853.69 1.545 1.543 1.547"/> </g> </symbol> <symbol id="icon-services-physicochemistryandbinding" viewBox="0 0 36 36"> <g fill="currentColor" fill-rule="nonzero"> <path d="M16.561.368a2.74 2.74 0 0 1 2.745 0l13.185 7.627a2.75 2.75 0 0 1 1.37 2.195l.007.184v15.255a2.751 2.751 0 0 1-1.376 2.376l-13.186 7.627c-.849.49-1.895.49-2.745 0L3.376 28.006A2.753 2.753 0 0 1 2 25.628V10.372a2.751 2.751 0 0 1 1.375-2.377L16.561.368Zm14.982 9.267L18.357 2.008a.846.846 0 0 0-.847 0L4.323 9.636a.856.856 0 0 0-.428.739v15.251c0 .305.164.587.429.74l13.186 7.627a.847.847 0 0 0 .848 0l13.186-7.627a.856.856 0 0 0 .429-.738V10.376a.857.857 0 0 0-.429-.74l.183-.319-.184.318Z"/><path d="M17.916 22.209a1.755 1.755 0 0 0 1.745-1.77c0-1.324-1.745-2.821-1.745-2.821s-1.745 1.501-1.745 2.821a1.755 1.755 0 0 0 1.745 1.77M12.494 24.415h10.843a.727.727 0 0 1 .538.22.759.759 0 0 1 .213.551.759.759 0 0 1-.212.55.727.727 0 0 1-.536.223H12.432a.696.696 0 0 1-.506-.235.726.726 0 0 1-.18-.538.759.759 0 0 1 .213-.549.727.727 0 0 1 .535-.222M13.274 4.068l3.24 4.54c.148.208.254.443.311.693.106.248.149.519.126.788v4.51h1.931v-4.51c.008-.273.071-.54.186-.788.072-.275.2-.533.374-.757l3.49-4.476 1.185.882-3.615 4.789v5.3s-.156 1.069-2.633 1.07c-2.478.003-2.477-1.07-2.477-1.07V9.68l-3.365-4.793 1.247-.82Z"/> </g> </symbol> <symbol id="icon-services-invitrotoxicology" viewBox="0 0 36 36"> <g fill="currentColor" fill-rule="nonzero"> <path d="M16.561.368a2.74 2.74 0 0 1 2.745 0l13.185 7.627a2.75 2.75 0 0 1 1.37 2.195l.007.184v15.255a2.751 2.751 0 0 1-1.376 2.376l-13.186 7.627c-.849.49-1.895.49-2.745 0L3.376 28.006A2.753 2.753 0 0 1 2 25.628V10.372a2.751 2.751 0 0 1 1.375-2.377L16.561.368Zm14.982 9.267L18.357 2.008a.846.846 0 0 0-.847 0L4.323 9.636a.856.856 0 0 0-.428.739v15.251c0 .305.164.587.429.74l13.186 7.627a.847.847 0 0 0 .848 0l13.186-7.627a.856.856 0 0 0 .429-.738V10.376a.857.857 0 0 0-.429-.74l.183-.319-.184.318Z"/><path d="m12 10.587 5.985 5.985 5.986-5.985A1 1 0 0 1 25.385 12L19.4 17.986l5.985 5.986a1 1 0 0 1-1.414 1.415L17.985 19.4 12 25.387a1 1 0 0 1-1.415-1.415l5.986-5.986L10.585 12A1 1 0 1 1 12 10.587Z"/> </g> </symbol> <symbol id="icon-services-biologics" viewBox="0 0 36 36"> <g fill="currentColor" fill-rule="nonzero"> <path d="M16.305.364a2.968 2.968 0 0 1 2.849 0l13.839 7.603-.963 1.753-13.84-7.603a.969.969 0 0 0-.922 0L3.428 9.72a.785.785 0 0 0-.428.677v15.204c0 .272.159.532.428.68l13.84 7.602a.97.97 0 0 0 .923 0l13.84-7.603a.785.785 0 0 0 .428-.677V10.4a.786.786 0 0 0-.428-.679l.962-1.753a2.785 2.785 0 0 1 1.466 2.43v15.208a2.783 2.783 0 0 1-1.465 2.428l-13.84 7.603a2.97 2.97 0 0 1-2.849 0L2.466 28.034A2.785 2.785 0 0 1 1 25.604v-15.21a2.783 2.783 0 0 1 1.465-2.427L16.305.364Z"/><path d="M25.559 10.097a1 1 0 1 1 1.502 1.321l-6.847 7.783.001 10.002a1 1 0 0 1-.883.993l-.117.007a1 1 0 0 1-1-1V18.446l.25-.283 7.094-8.066Zm-16.965-.09a1 1 0 0 1 1.411.09l7.095 8.066.25.283v10.757a1 1 0 1 1-2 0L15.347 19.2l-6.844-7.782a1 1 0 0 1 .001-1.322l.09-.089Zm19.274 1.937a1 1 0 1 1 1.506 1.317l-6.566 7.503a1 1 0 1 1-1.505-1.317l6.565-7.503ZM6.285 11.85a1 1 0 0 1 1.41.094l6.566 7.503a1 1 0 1 1-1.505 1.317L6.191 13.26a1 1 0 0 1 .094-1.411Z"/> </g> </symbol>  <symbol id="icon-twitter" viewBox="0 0 100 100"> <path fill="currentColor" fill-rule="evenodd" d="m54 2.31 35.301 20.38a8 8 0 0 1 4 6.929V70.38a8 8 0 0 1-4 6.928L54 97.691a8 8 0 0 1-8 0L10.699 77.309a8 8 0 0 1-4-6.928V29.62a8 8 0 0 1 4-6.928L46 2.309a8 8 0 0 1 8 0ZM69.169 41.22A20.372 20.372 0 0 0 74 36.394c-1.73.722-3.608 1.243-5.547 1.445 1.998-1.156 3.519-2.977 4.235-5.145a19.335 19.335 0 0 1-6.114 2.254C64.814 33.128 62.31 32 59.536 32c-5.338 0-9.632 4.191-9.632 9.337 0 .722.089 1.445.238 2.139-7.992-.405-15.12-4.105-19.862-9.77a9.05 9.05 0 0 0-1.312 4.711c0 3.238 1.7 6.1 4.295 7.776a9.934 9.934 0 0 1-4.354-1.185v.115c0 4.539 3.31 8.296 7.724 9.164-.806.202-1.67.318-2.535.318-.627 0-1.223-.058-1.82-.145 1.223 3.7 4.772 6.388 9.007 6.475-3.31 2.515-7.456 3.99-11.959 3.99-.805 0-1.55-.03-2.326-.116C31.265 67.468 36.334 69 41.792 69c17.715 0 27.407-14.222 27.407-26.565 0-.405 0-.81-.03-1.214Z" /> </symbol> <symbol id="icon-linkedin" viewBox="0 0 100 100"> <path fill="currentColor" fill-rule="evenodd" d="m54 2.31 35.301 20.38a8 8 0 0 1 4 6.929V70.38a8 8 0 0 1-4 6.928L54 97.691a8 8 0 0 1-8 0L10.699 77.309a8 8 0 0 1-4-6.928V29.62a8 8 0 0 1 4-6.928L46 2.309a8 8 0 0 1 8 0ZM39.177 69V41.626h-8.5V69h8.5Zm-4.254-31.108c2.717 0 4.922-2.251 4.922-4.97a4.923 4.923 0 1 0-9.845 0c0 2.719 2.205 4.97 4.923 4.97ZM70.99 69H71V53.963c0-7.358-1.581-13.023-10.184-13.023-4.136 0-6.908 2.27-8.043 4.42h-.119v-3.734h-8.152V69h8.49V55.446c0-3.57.678-7.02 5.098-7.02 4.355 0 4.419 4.073 4.419 7.249V69h8.482Z" /> </symbol> <symbol id="icon-youtube" viewBox="0 0 100 100"> <path fill="currentColor" fill-rule="evenodd" d="m53 1.31 35.301 20.38a8 8 0 0 1 4 6.929V69.38a8 8 0 0 1-4 6.928L53 96.691a8 8 0 0 1-8 0L9.699 76.309a8 8 0 0 1-4-6.928V28.62a8 8 0 0 1 4-6.928L45 1.309a8 8 0 0 1 8 0Zm20.934 36.166c-.586-2.155-2.314-3.853-4.509-4.43C65.448 32 49.5 32 49.5 32s-15.948 0-19.925 1.047c-2.195.576-3.923 2.274-4.51 4.43C24 41.382 24 49.534 24 49.534s0 8.152 1.066 12.06c.586 2.155 2.314 3.782 4.509 4.358C33.552 67 49.5 67 49.5 67s15.948 0 19.925-1.047c2.195-.576 3.923-2.203 4.51-4.359C75 57.687 75 49.535 75 49.535s0-8.152-1.066-12.059Zm-29.65 19.46V42.135l13.33 7.402-13.33 7.4Z" /> </symbol> <symbol id="icon-arrow-down" viewBox="0 0 36 36"> <path fill="currentColor" fill-rule="nonzero" d="M6.828 8.172a4 4 0 1 0-5.656 5.656L15.12 27.776a4 4 0 0 0 5.656 0L34.728 13.83a4 4 0 0 0-5.656-5.658l-11.124 11.12-11.12-11.12Z"/> </symbol> <symbol id="icon-arrow-hero-prev" viewBox="0 0 36 36"> <path fill="currentColor" fill-rule="nonzero" d="M2.32 18 18.68 1.64A.96.96 0 0 0 17.32.281L.281 17.321a.96.96 0 0 0 0 1.358l17.04 17.04a.96.96 0 0 0 1.358-1.359L2.32 18Z"/> </symbol> <symbol id="icon-arrow-hero-next" viewBox="0 0 36 36"> <path fill="currentColor" fill-rule="nonzero" d="m33.641 18-16.36 16.36a.96.96 0 1 0 1.359 1.359l17.04-17.04a.96.96 0 0 0 0-1.358L18.64.28a.96.96 0 0 0-1.359 1.359L33.641 18Z"/> </symbol> <symbol id="icon-search" viewBox="0 0 36 36"> <path fill="currentColor" fill-rule="nonzero" d="m34.103 32.343-8.287-8.516a13.752 13.752 0 0 0 3.299-8.933C29.06 7.179 22.772.964 15.057 1 7.343.964 1.054 7.18 1 14.894c.051 7.716 6.34 13.935 14.057 13.898a14.02 14.02 0 0 0 8.054-2.514l8.349 8.577c.346.357.824.558 1.321.556.473.002.928-.18 1.271-.505a1.8 1.8 0 0 0 .05-2.563M15.058 4.626c5.701-.027 10.349 4.565 10.39 10.266-.041 5.701-4.689 10.294-10.39 10.267-5.7.027-10.349-4.566-10.39-10.267.041-5.7 4.69-10.293 10.39-10.266"/> </symbol> <symbol id="icon-hamburger" viewBox="0 0 36 36"> <g fill="currentColor" fill-rule="nonzero"><path d="M0 8.182h36V4.909H0zM0 19.106h36v-3.273H0zM0 30.031h36v-3.273H0z"/></g> </symbol> <symbol id="icon-vacancies-arrow" viewBox="0 0 3157 420"> <path fill="currentColor" fill-rule="nonzero" d="M3152.737 222.593a25.489 25.489 0 0 0 0-25.179L3047.491 12.589A24.774 24.774 0 0 0 3025.986.003H.328v420h3025.658a24.774 24.774 0 0 0 21.5-12.589l105.251-184.821Z"/> </symbol> <symbol id="icon-times" viewBox="0 0 320 512"> <path fill="currentColor" d="M310.6 150.6c12.5-12.5 12.5-32.8 0-45.3s-32.8-12.5-45.3 0L160 210.7 54.6 105.4c-12.5-12.5-32.8-12.5-45.3 0s-12.5 32.8 0 45.3L114.7 256 9.4 361.4c-12.5 12.5-12.5 32.8 0 45.3s32.8 12.5 45.3 0L160 301.3 265.4 406.6c12.5 12.5 32.8 12.5 45.3 0s12.5-32.8 0-45.3L205.3 256 310.6 150.6z"/> </symbol> <symbol id="icon-download-label" viewBox="0 0 118.495 104.107"> <g><path fill="currentColor" d="M118.498 0H28.874a5.428 5.428 0 0 0-4.772 3.121L.741 48.934a6.964 6.964 0 0 0 0 6.241l23.361 45.813a5.43 5.43 0 0 0 4.773 3.118h89.623"/></g> </symbol> <symbol id="icon-download" viewBox="0 0 39.946 55.06"> <path fill="currentColor" d="M39.483 12.254 29.295.636A1.866 1.866 0 0 0 27.892 0H2.159A2.159 2.159 0 0 0 0 2.159V52.9a2.159 2.159 0 0 0 2.159 2.16h35.627a2.159 2.159 0 0 0 2.16-2.16V13.484a1.866 1.866 0 0 0-.463-1.23"/> </symbol> <symbol id="icon-download-file" viewBox="0 0 180 180"> <path fill="currentColor" fill-rule="nonzero" d="M115.134 0a9.705 9.705 0 0 1 7.298 3.307l31.857 36.328.728.933a9.703 9.703 0 0 1 1.62 4.322l.066 1.168v123.316c0 5.868-4.757 10.626-10.626 10.626H34.627A10.626 10.626 0 0 1 24 169.374V10.626C24 4.758 28.758 0 34.626 0h80.508Zm-6.138 14.489H38.49v151.278h103.726V52.42l-25.967.008a7.245 7.245 0 0 1-7.195-6.4l-.049-.844-.008-30.695Zm6.138-6.75h-1.277l2.887 2.887-.008 34.055 29.349.007 2.879 2.872v-1.517a1.966 1.966 0 0 0-.22-.912l-.26-.375L116.612 8.41a1.966 1.966 0 0 0-1.478-.67Z"/> </symbol> <symbol id="downloads-checkbox-default" viewBox="0 0 180 180"> <g fill="none" fill-rule="nonzero"><path fill="#00A5C8" d="M154.075 40.06 120.769 2.083A6.096 6.096 0 0 0 116.183 0H32.059A7.059 7.059 0 0 0 25 7.059V172.94A7.059 7.059 0 0 0 32.059 180h116.47a7.059 7.059 0 0 0 7.059-7.059V44.082a6.1 6.1 0 0 0-1.515-4.016M32.06 173.226V7.06h81.766v36.114a3.529 3.529 0 0 0 3.53 3.53h31.174v126.524H32.06Z"/><path fill="#923189" d="M121.012 78.327 91.974 61.531a3.95 3.95 0 0 0-3.956 0l-29.04 16.796A3.965 3.965 0 0 0 57 81.76v33.592c0 1.415.754 2.722 1.979 3.43l29.039 16.797a3.951 3.951 0 0 0 3.956 0l29.04-16.797a3.966 3.966 0 0 0 1.976-3.432V81.76a3.965 3.965 0 0 0-1.978-3.432"/><path fill="#FFF" d="M105.121 100.732v-4.403H91.792V83h-4.404v13.329H74v4.403h13.388v13.329h4.404v-13.329z"/></g> </symbol> <symbol id="downloads-checkbox-checked" viewBox="0 0 180 180"> <g fill="none" fill-rule="nonzero"><path fill="#00A5C8" d="M154.075 40.06 120.769 2.083A6.096 6.096 0 0 0 116.183 0H32.059A7.059 7.059 0 0 0 25 7.059V172.94A7.059 7.059 0 0 0 32.059 180h116.47a7.059 7.059 0 0 0 7.059-7.059V44.082a6.1 6.1 0 0 0-1.515-4.016M32.06 173.226V7.06h81.766v36.114a3.529 3.529 0 0 0 3.53 3.53h31.174v126.524H32.06Z"/><path fill="#00A5C8" d="M121.31 78.382 92.272 61.585a3.95 3.95 0 0 0-3.955 0l-29.04 16.797a3.965 3.965 0 0 0-1.978 3.432v33.591c0 1.415.754 2.723 1.978 3.43l29.04 16.797a3.951 3.951 0 0 0 3.955 0l29.04-16.796a3.966 3.966 0 0 0 1.977-3.432v-33.59a3.965 3.965 0 0 0-1.979-3.432"/><path fill="#FFF" d="M105.121 100.732v-4.403H74v4.403z"/></g> </symbol> </svg> </div>  <script type="rocketlazyloadscript" data-minify="1" data-rocket-type="text/javascript" id="hs-script-loader" async defer data-rocket-src="https://symeres.com/wp-content/cache/min/1/25214463.js?ver=1732266183"></script>  </div></div> <section class="downloads__aside" id="sidebar-downloads"> <button class="downloads__label"> <span>0</span> <svg><use xlink:href="#icon-download"></use></svg> </button> <div class="downloads__content"> <button class="downloads__close" id="downloads-close"><svg xmlns:xlink="http://www.w3.org/1999/xlink"><title>Close this panel</title><use xlink:href="#icon-times"></use></svg></button> <div id="selected-files" class="downloads__files"> <h3>Files</h3> <div> <ul></ul> </div> <button style="margin-top:20px;" id="remove-all-files" type="submit" class="button">Remove all</button> </div> <form class="downloads__form form" action="https://symeres.com/wp-admin/admin-ajax.php" method="POST" id="actualsymeresdownloads"> <p>Please, provide us your email address so that we can send you a link for downloading the requested files.</p> <div class="form__row"> <div class="form__col"> <label for="first-name">First name</label> <input id="first-name" name="first-name" type="text" placeholder="First name" required> </div> <div class="form__col"> <label for="last-name">Last name</label> <input id="last-name" name="last-name" type="text" placeholder="Last name" required> </div> </div> <div class="form__row"> <div class="form__col"> <label for="company">Company</label> <input id="company" name="company" type="text" placeholder="Company" required> </div> </div> <div class="form__row"> <div class="form__col"> <label for="email">Corporate email</label> <input id="email" name="email" type="email" placeholder="Corporate email" required> </div> </div> <div class="form__row"> <div class="form__col"> <label for="agreement"> <input id="agreement" name="agreement" type="checkbox" required> <div>By downloading, I agree to the <a href='/privacy-policy/'>privacy policy</a></div> </label> </div> </div> <div class="form__row"> <div class="form__col"> <input type="text" name="downloaded_files" value="" style="opacity: 0;height: 0;overflow: hidden;"> <button type="submit" class="button button--primary">Download file(s)</button> <input type="hidden" name="action" value="symeresdownloads"> </div> </div> </form> </div> </section><script type="rocketlazyloadscript">window.addEventListener('DOMContentLoaded', function() { jQuery( document ).ready(function() { jQuery(function ($) { let downloads = {}; $('body').on('click', '#downloads-close', function(){ $('.downloads__label').css('display', 'flex'); $('.downloads__content').css('display', 'none'); }); $('body').on('click', '.downloads__label', function(){ $('.downloads__label').css('display', 'none'); $('.downloads__content').css('display', 'flex'); }); $('body').on('change', 'form.downloads', function(){ let downloadsList = ''; let filenames = {}; $('input:checkbox[name=download]').each(function(){ filenames[$(this).data('filename')] = $(this).data('filetitle'); if (this.checked) { downloads[$(this).data('download')] = $(this).data('filename'); } else { if ($(this).data('download') in downloads) { delete downloads[$(this).data('download')]; } if (localStorage.getItem('downloads')) { let downloadsFromLocalStorage = JSON.parse(localStorage.getItem('downloads')); if ($(this).data('download') in downloadsFromLocalStorage) { delete downloadsFromLocalStorage[$(this).data('download')]; localStorage.setItem('downloads', JSON.stringify(downloadsFromLocalStorage)); } } } $('input[name="downloaded_files"]').val(Object.values(filenames).join(',')); }); // set filenames + titles in localStorage if (Object.keys(filenames).length) { let filenamesJson = JSON.stringify(filenames); if (localStorage.getItem('filenames')) { let currentFilenames = JSON.parse(localStorage.getItem('filenames')); filenames = { ...currentFilenames, ...filenames }; filenamesJson = JSON.stringify(filenames); } localStorage.setItem('filenames', filenamesJson); } if (Object.keys(downloads).length) { $('.downloads__aside').css('display', 'block'); let downloadsJson = JSON.stringify(downloads); if (localStorage.getItem('downloads')) { let currentDownloads = JSON.parse(localStorage.getItem('downloads')); downloads = { ...currentDownloads, ...downloads }; downloadsJson = JSON.stringify(downloads); } localStorage.setItem('downloads', downloadsJson); } else { if (!localStorage.getItem('downloads')) { localStorage.removeItem('downloads'); } } Object.keys(downloads).forEach(key => { let label = $('.downloads li label[for="download-file-' + downloads[key] + '"]').text(); if (localStorage.getItem('downloads')) { let downloadsFromLocalStorage = JSON.parse(localStorage.getItem('downloads')); if (localStorage.getItem('filenames')) { let filenames = JSON.parse(localStorage.getItem('filenames')); if (downloadsFromLocalStorage[key] in filenames) { label = filenames[downloadsFromLocalStorage[key]]; } } if (label === '') { label = $('.downloads li label[for="download-file-' + downloadsFromLocalStorage[key] + '"]').text(); } } downloadsList += '<li><button data-download="' + key + '"><svg class="downloads__delete"><use xlink:href="#icon-times"></use></svg></button><span><svg class="downloads__icon"><use xlink:href="#icon-download-file"></use></svg></span>' + label.trim() + '</li>'; }); $('.downloads__label span').text(Object.keys(downloads).length); $('#selected-files ul').html(downloadsList); // if (Object.keys(downloads).length) { //if (localStorage.getItem('downloads')) { // $('.downloads__aside').css('display', 'block'); // } else { // $('.downloads__aside').css('display', 'none'); // } }); if (localStorage.getItem('downloads')) { let downloadsFromLocalStorage = JSON.parse(localStorage.getItem('downloads')); let downloadsList = ''; $("input[name='downloaded_files']").val(Object.values(downloadsFromLocalStorage).join(',')); Object.keys(downloadsFromLocalStorage).forEach(key => { $(".downloads ul").find("[data-filename='" + downloadsFromLocalStorage[key] + "']").prop('checked', true); let label = ''; if (localStorage.getItem('filenames')) { let filenames = JSON.parse(localStorage.getItem('filenames')); if (downloadsFromLocalStorage[key] in filenames) { label = filenames[downloadsFromLocalStorage[key]]; } } if (label === '') { label = $('.downloads li label[for="download-file-' + downloadsFromLocalStorage[key] + '"]').text(); } downloadsList += '<li><button data-download="' + key + '"><svg class="downloads__delete"><use xlink:href="#icon-times"></use></svg></button><span><svg class="downloads__icon"><use xlink:href="#icon-download-file"></use></svg></span>' + label.trim() + '</li>'; }); $('.downloads__label span').text(Object.keys(downloadsFromLocalStorage).length); $('#selected-files ul').html(downloadsList); $('.downloads__aside').css('display', 'block'); } else { $('.downloads__aside').css('display', 'none'); } $('body').on('click', '#remove-all-files', function(){ localStorage.removeItem('downloads'); $('#selected-files div ul li').remove(); $('.downloads__aside').css('display', 'none'); location.reload(); }); $('body').on('click', '#selected-files button', function(){ $('form.downloads input[data-download=' + $(this).data('download') + ']').prop('checked', false).trigger('change'); if (localStorage.getItem('downloads')) { let downloadsLocalObj = JSON.parse(localStorage.getItem('downloads')); if ($(this).data('download') in downloadsLocalObj) { delete downloadsLocalObj[$(this).data('download')]; localStorage.setItem('downloads', JSON.stringify(downloadsLocalObj)); //reload sidebar html let downloadsList = ''; Object.keys(downloadsLocalObj).forEach(key => { $(".downloads ul").find("[data-filename='" + downloadsLocalObj[key] + "']").prop('checked', true); let label = ''; if (localStorage.getItem('filenames')) { let filenames = JSON.parse(localStorage.getItem('filenames')); if (downloadsLocalObj[key] in filenames) { label = filenames[downloadsLocalObj[key]]; } } if (label === '') { label = $('.downloads li label[for="download-file-' + downloadsLocalObj[key] + '"]').text(); } downloadsList += '<li><button data-download="' + key + '"><svg class="downloads__delete"><use xlink:href="#icon-times"></use></svg></button><span><svg class="downloads__icon"><use xlink:href="#icon-download-file"></use></svg></span>' + label.trim() + '</li>'; }); $('.downloads__label span').text(Object.keys(downloadsLocalObj).length); $('#selected-files ul').html(downloadsList); $('.downloads__aside').css('display', 'block'); } } }); $('#actualsymeresdownloads').on('submit', function (e) { e.preventDefault(); if (localStorage.getItem('downloads')) { downloads = JSON.parse(localStorage.getItem('downloads')); $("input[name='downloaded_files']").val(''); $("input[name='downloaded_files']").val(Object.values(downloads).join(',')); } var symeresdownloads = $('#actualsymeresdownloads'); var email = $("#actualsymeresdownloads :input[name='email']").val(); var firstName = $("#actualsymeresdownloads :input[name='first-name']").val(); var lastName = $("#actualsymeresdownloads :input[name='last-name']").val(); var company = $("#actualsymeresdownloads :input[name='company']").val(); var action = $("#actualsymeresdownloads :input[name='action']").val(); downloads['email'] = email; downloads['first-name'] = firstName; downloads['last-name'] = lastName; downloads['company'] = company; downloads['action'] = action; runAjaxCall(symeresdownloads, downloads); // Clean up the downloads object delete downloads['email']; delete downloads['first-name']; delete downloads['last-name']; delete downloads['company']; delete downloads['action']; e.preventDefault(); }); function runAjaxCall(symeresdownloads, downloads) { var array = Object.keys(downloads).map((key) => [String(key), downloads[key]]); $.ajax({ url: symeresdownloads.attr('action'), data: downloads, // form data type: symeresdownloads.attr('method'), // POST beforeSend: function (xhr) { jQuery('#actualsymeresdownloads button').hide(); jQuery('<p class="download-status">Your file(s) are being processed.</p>').insertAfter('#actualsymeresdownloads button'); }, success: function (data) { let error = false; if (data.includes('address') || data.includes('download')) { if (!data.includes('Thank you')) { error = true; jQuery('.download-status').remove(); jQuery('.downloads__content').append('<div class="status-msg" style="font-weight:500; color: #FFF;">' + data + '</div>') } } if (data.includes('Thank you')) { error = false; jQuery('.download-status').remove(); jQuery('.downloads__content').append('<div class="status-msg" style="font-weight:500; color: #FFF;">' + data + '</div>') } setTimeout(function(){ jQuery('.status-msg').remove(); if (error) { jQuery('input#email').css('border-color', '#d63637'); location.reload(); } if (!error) { localStorage.removeItem('downloads'); $('.downloads__aside').css('display', 'none'); location.reload(); } }, 5000); } }); } if ($('.downloads__label span').text() == '0') { $('.downloads__aside').css('display', 'none'); } $('body').on('change', '.downloads__label span', function(){ if ($('.downloads__label span').text() == '0') { $('.downloads__aside').css('display', 'none'); } }); }); }); });</script><script type="rocketlazyloadscript" id="wp-block-template-skip-link-js-after"> ( function() { var skipLinkTarget = document.querySelector( 'main' ), sibling, skipLinkTargetID, skipLink; // Early exit if a skip-link target can't be located. if ( ! skipLinkTarget ) { return; } /* * Get the site wrapper. * The skip-link will be injected in the beginning of it. */ sibling = document.querySelector( '.wp-site-blocks' ); // Early exit if the root element was not found. if ( ! sibling ) { return; } // Get the skip-link target's ID, and generate one if it doesn't exist. skipLinkTargetID = skipLinkTarget.id; if ( ! skipLinkTargetID ) { skipLinkTargetID = 'wp--skip-link--target'; skipLinkTarget.id = skipLinkTargetID; } // Create the skip link. skipLink = document.createElement( 'a' ); skipLink.classList.add( 'skip-link', 'screen-reader-text' ); skipLink.href = '#' + skipLinkTargetID; skipLink.innerHTML = 'Skip to content'; // Inject the skip link. sibling.parentElement.insertBefore( skipLink, sibling ); }() ); </script> <script id="leadin-script-loader-js-js-extra"> var leadin_wordpress = {"userRole":"visitor","pageType":"page","leadinPluginVersion":"11.1.73"}; </script> <script type="rocketlazyloadscript" data-minify="1" data-rocket-src="https://symeres.com/wp-content/cache/min/1/25214463.js?ver=1732266183" id="leadin-script-loader-js-js" data-rocket-defer defer></script> <script type="rocketlazyloadscript" data-rocket-src="https://symeres.com/wp-content/plugins/easy-table-of-contents/vendor/js-cookie/js.cookie.min.js?ver=2.2.1" id="ez-toc-js-cookie-js" data-rocket-defer defer></script> <script type="rocketlazyloadscript" data-rocket-src="https://symeres.com/wp-content/plugins/easy-table-of-contents/vendor/sticky-kit/jquery.sticky-kit.min.js?ver=1.9.2" id="ez-toc-jquery-sticky-kit-js" data-rocket-defer defer></script> <script id="ez-toc-js-js-extra"> var ezTOC = {"smooth_scroll":"1","scroll_offset":"30","fallbackIcon":"<span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span>","chamomile_theme_is_on":""}; </script> <script type="rocketlazyloadscript" data-rocket-src="https://symeres.com/wp-content/plugins/easy-table-of-contents/assets/js/front.min.js?ver=2.0.69.1-1730987172" id="ez-toc-js-js" data-rocket-defer defer></script> <script id="ez-toc-scroll-scriptjs-js-extra"> var eztoc_smooth_local = {"scroll_offset":"30","add_request_uri":""}; </script> <script type="rocketlazyloadscript" data-rocket-src="https://symeres.com/wp-content/plugins/easy-table-of-contents/assets/js/smooth_scroll.min.js?ver=2.0.69.1" id="ez-toc-scroll-scriptjs-js" data-rocket-defer defer></script> <script type="rocketlazyloadscript" id="rocket-browser-checker-js-after"> "use strict";var _createClass=function(){function defineProperties(target,props){for(var i=0;i<props.length;i++){var descriptor=props[i];descriptor.enumerable=descriptor.enumerable||!1,descriptor.configurable=!0,"value"in descriptor&&(descriptor.writable=!0),Object.defineProperty(target,descriptor.key,descriptor)}}return function(Constructor,protoProps,staticProps){return protoProps&&defineProperties(Constructor.prototype,protoProps),staticProps&&defineProperties(Constructor,staticProps),Constructor}}();function _classCallCheck(instance,Constructor){if(!(instance instanceof Constructor))throw new TypeError("Cannot call a class as a function")}var RocketBrowserCompatibilityChecker=function(){function RocketBrowserCompatibilityChecker(options){_classCallCheck(this,RocketBrowserCompatibilityChecker),this.passiveSupported=!1,this._checkPassiveOption(this),this.options=!!this.passiveSupported&&options}return _createClass(RocketBrowserCompatibilityChecker,[{key:"_checkPassiveOption",value:function(self){try{var options={get passive(){return!(self.passiveSupported=!0)}};window.addEventListener("test",null,options),window.removeEventListener("test",null,options)}catch(err){self.passiveSupported=!1}}},{key:"initRequestIdleCallback",value:function(){!1 in window&&(window.requestIdleCallback=function(cb){var start=Date.now();return setTimeout(function(){cb({didTimeout:!1,timeRemaining:function(){return Math.max(0,50-(Date.now()-start))}})},1)}),!1 in window&&(window.cancelIdleCallback=function(id){return clearTimeout(id)})}},{key:"isDataSaverModeOn",value:function(){return"connection"in navigator&&!0===navigator.connection.saveData}},{key:"supportsLinkPrefetch",value:function(){var elem=document.createElement("link");return elem.relList&&elem.relList.supports&&elem.relList.supports("prefetch")&&window.IntersectionObserver&&"isIntersecting"in IntersectionObserverEntry.prototype}},{key:"isSlowConnection",value:function(){return"connection"in navigator&&"effectiveType"in navigator.connection&&("2g"===navigator.connection.effectiveType||"slow-2g"===navigator.connection.effectiveType)}}]),RocketBrowserCompatibilityChecker}(); </script> <script id="rocket-preload-links-js-extra"> var RocketPreloadLinksConfig = {"excludeUris":"\/(?:.+\/)?feed(?:\/(?:.+\/?)?)?$|\/(?:.+\/)?embed\/|\/(index.php\/)?(.*)wp-json(\/.*|$)|\/refer\/|\/go\/|\/recommend\/|\/recommends\/","usesTrailingSlash":"1","imageExt":"jpg|jpeg|gif|png|tiff|bmp|webp|avif|pdf|doc|docx|xls|xlsx|php","fileExt":"jpg|jpeg|gif|png|tiff|bmp|webp|avif|pdf|doc|docx|xls|xlsx|php|html|htm","siteUrl":"https:\/\/symeres.com","onHoverDelay":"100","rateThrottle":"3"}; </script> <script type="rocketlazyloadscript" id="rocket-preload-links-js-after"> (function() { "use strict";var r="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(e){return typeof e}:function(e){return e&&"function"==typeof Symbol&&e.constructor===Symbol&&e!==Symbol.prototype?"symbol":typeof e},e=function(){function i(e,t){for(var n=0;n<t.length;n++){var i=t[n];i.enumerable=i.enumerable||!1,i.configurable=!0,"value"in i&&(i.writable=!0),Object.defineProperty(e,i.key,i)}}return function(e,t,n){return t&&i(e.prototype,t),n&&i(e,n),e}}();function i(e,t){if(!(e instanceof t))throw new TypeError("Cannot call a class as a function")}var t=function(){function n(e,t){i(this,n),this.browser=e,this.config=t,this.options=this.browser.options,this.prefetched=new Set,this.eventTime=null,this.threshold=1111,this.numOnHover=0}return e(n,[{key:"init",value:function(){!this.browser.supportsLinkPrefetch()||this.browser.isDataSaverModeOn()||this.browser.isSlowConnection()||(this.regex={excludeUris:RegExp(this.config.excludeUris,"i"),images:RegExp(".("+this.config.imageExt+")$","i"),fileExt:RegExp(".("+this.config.fileExt+")$","i")},this._initListeners(this))}},{key:"_initListeners",value:function(e){-1<this.config.onHoverDelay&&document.addEventListener("mouseover",e.listener.bind(e),e.listenerOptions),document.addEventListener("mousedown",e.listener.bind(e),e.listenerOptions),document.addEventListener("touchstart",e.listener.bind(e),e.listenerOptions)}},{key:"listener",value:function(e){var t=e.target.closest("a"),n=this._prepareUrl(t);if(null!==n)switch(e.type){case"mousedown":case"touchstart":this._addPrefetchLink(n);break;case"mouseover":this._earlyPrefetch(t,n,"mouseout")}}},{key:"_earlyPrefetch",value:function(t,e,n){var i=this,r=setTimeout(function(){if(r=null,0===i.numOnHover)setTimeout(function(){return i.numOnHover=0},1e3);else if(i.numOnHover>i.config.rateThrottle)return;i.numOnHover++,i._addPrefetchLink(e)},this.config.onHoverDelay);t.addEventListener(n,function e(){t.removeEventListener(n,e,{passive:!0}),null!==r&&(clearTimeout(r),r=null)},{passive:!0})}},{key:"_addPrefetchLink",value:function(i){return this.prefetched.add(i.href),new Promise(function(e,t){var n=document.createElement("link");n.rel="prefetch",n.href=i.href,n.onload=e,n.onerror=t,document.head.appendChild(n)}).catch(function(){})}},{key:"_prepareUrl",value:function(e){if(null===e||"object"!==(void 0===e?"undefined":r(e))||!1 in e||-1===["http:","https:"].indexOf(e.protocol))return null;var t=e.href.substring(0,this.config.siteUrl.length),n=this._getPathname(e.href,t),i={original:e.href,protocol:e.protocol,origin:t,pathname:n,href:t+n};return this._isLinkOk(i)?i:null}},{key:"_getPathname",value:function(e,t){var n=t?e.substring(this.config.siteUrl.length):e;return n.startsWith("/")||(n="/"+n),this._shouldAddTrailingSlash(n)?n+"/":n}},{key:"_shouldAddTrailingSlash",value:function(e){return this.config.usesTrailingSlash&&!e.endsWith("/")&&!this.regex.fileExt.test(e)}},{key:"_isLinkOk",value:function(e){return null!==e&&"object"===(void 0===e?"undefined":r(e))&&(!this.prefetched.has(e.href)&&e.origin===this.config.siteUrl&&-1===e.href.indexOf("?")&&-1===e.href.indexOf("#")&&!this.regex.excludeUris.test(e.href)&&!this.regex.images.test(e.href))}}],[{key:"run",value:function(){"undefined"!=typeof RocketPreloadLinksConfig&&new n(new RocketBrowserCompatibilityChecker({capture:!0,passive:!0}),RocketPreloadLinksConfig).init()}}]),n}();t.run(); }()); </script> <script id="rocket_lazyload_css-js-extra"> var rocket_lazyload_css_data = {"threshold":"300"}; </script> <script id="rocket_lazyload_css-js-after"> !function o(n,c,a){function u(t,e){if(!c[t]){if(!n[t]){var r="function"==typeof require&&require;if(!e&&r)return r(t,!0);if(s)return s(t,!0);throw(e=new Error("Cannot find module '"+t+"'")).code="MODULE_NOT_FOUND",e}r=c[t]={exports:{}},n[t][0].call(r.exports,function(e){return u(n[t][1][e]||e)},r,r.exports,o,n,c,a)}return c[t].exports}for(var s="function"==typeof require&&require,e=0;e<a.length;e++)u(a[e]);return u}({1:[function(e,t,r){"use strict";{const c="undefined"==typeof rocket_pairs?[]:rocket_pairs,a=(("undefined"==typeof rocket_excluded_pairs?[]:rocket_excluded_pairs).map(t=>{var e=t.selector;document.querySelectorAll(e).forEach(e=>{e.setAttribute("data-rocket-lazy-bg-"+t.hash,"excluded")})}),document.querySelector("#wpr-lazyload-bg-container"));var o=rocket_lazyload_css_data.threshold||300;const u=new IntersectionObserver(e=>{e.forEach(t=>{t.isIntersecting&&c.filter(e=>t.target.matches(e.selector)).map(t=>{var e;t&&((e=document.createElement("style")).textContent=t.style,a.insertAdjacentElement("afterend",e),t.elements.forEach(e=>{u.unobserve(e),e.setAttribute("data-rocket-lazy-bg-"+t.hash,"loaded")}))})})},{rootMargin:o+"px"});function n(){0<(0<arguments.length&&void 0!==arguments[0]?arguments[0]:[]).length&&c.forEach(t=>{try{document.querySelectorAll(t.selector).forEach(e=>{"loaded"!==e.getAttribute("data-rocket-lazy-bg-"+t.hash)&&"excluded"!==e.getAttribute("data-rocket-lazy-bg-"+t.hash)&&(u.observe(e),(t.elements||=[]).push(e))})}catch(e){console.error(e)}})}n(),function(){const r=window.MutationObserver;return function(e,t){if(e&&1===e.nodeType)return(t=new r(t)).observe(e,{attributes:!0,childList:!0,subtree:!0}),t}}()(document.querySelector("body"),n)}},{}]},{},[1]); </script> <script type="rocketlazyloadscript" data-rocket-src="https://symeres.com/wp-includes/js/hoverIntent.min.js?ver=1.10.2" id="hoverIntent-js" data-rocket-defer defer></script> <script type="rocketlazyloadscript" data-minify="1" data-rocket-src="https://symeres.com/wp-content/cache/min/1/wp-content/plugins/megamenu/js/maxmegamenu.js?ver=1732266183" id="megamenu-js" data-rocket-defer defer></script> <style> </style> <script type="rocketlazyloadscript"> document.addEventListener("DOMContentLoaded", function(event) { }); </script> <script type="rocketlazyloadscript"> var accordions_active = null; var accordions_tabs_active = null; </script> <script>window.lazyLoadOptions=[{elements_selector:"img[data-lazy-src],.rocket-lazyload,iframe[data-lazy-src]",data_src:"lazy-src",data_srcset:"lazy-srcset",data_sizes:"lazy-sizes",class_loading:"lazyloading",class_loaded:"lazyloaded",threshold:300,callback_loaded:function(element){if(element.tagName==="IFRAME"&&element.dataset.rocketLazyload=="fitvidscompatible"){if(element.classList.contains("lazyloaded")){if(typeof window.jQuery!="undefined"){if(jQuery.fn.fitVids){jQuery(element).parent().fitVids()}}}}}},{elements_selector:".rocket-lazyload",data_src:"lazy-src",data_srcset:"lazy-srcset",data_sizes:"lazy-sizes",class_loading:"lazyloading",class_loaded:"lazyloaded",threshold:300,}];window.addEventListener('LazyLoad::Initialized',function(e){var lazyLoadInstance=e.detail.instance;if(window.MutationObserver){var observer=new MutationObserver(function(mutations){var image_count=0;var iframe_count=0;var rocketlazy_count=0;mutations.forEach(function(mutation){for(var i=0;i<mutation.addedNodes.length;i++){if(typeof mutation.addedNodes[i].getElementsByTagName!=='function'){continue} if(typeof mutation.addedNodes[i].getElementsByClassName!=='function'){continue} images=mutation.addedNodes[i].getElementsByTagName('img');is_image=mutation.addedNodes[i].tagName=="IMG";iframes=mutation.addedNodes[i].getElementsByTagName('iframe');is_iframe=mutation.addedNodes[i].tagName=="IFRAME";rocket_lazy=mutation.addedNodes[i].getElementsByClassName('rocket-lazyload');image_count+=images.length;iframe_count+=iframes.length;rocketlazy_count+=rocket_lazy.length;if(is_image){image_count+=1} if(is_iframe){iframe_count+=1}}});if(image_count>0||iframe_count>0||rocketlazy_count>0){lazyLoadInstance.update()}});var b=document.getElementsByTagName("body")[0];var config={childList:!0,subtree:!0};observer.observe(b,config)}},!1)</script><script data-no-minify="1" async src="https://symeres.com/wp-content/plugins/wp-rocket/assets/js/lazyload/17.8.3/lazyload.min.js"></script><script>function lazyLoadThumb(e,alt,l){var t='<img data-lazy-src="https://i.ytimg.com/vi/ID/hqdefault.jpg" alt="" width="480" height="360"><noscript><img src="https://i.ytimg.com/vi/ID/hqdefault.jpg" alt="" width="480" height="360"></noscript>',a='<button class="play" aria-label="play Youtube video"></button>';if(l){t=t.replace('data-lazy-','');t=t.replace('loading="lazy"','');t=t.replace(/<noscript>.*?<\/noscript>/g,'');}t=t.replace('alt=""','alt="'+alt+'"');return t.replace("ID",e)+a}function lazyLoadYoutubeIframe(){var e=document.createElement("iframe"),t="ID?autoplay=1";t+=0===this.parentNode.dataset.query.length?"":"&"+this.parentNode.dataset.query;e.setAttribute("src",t.replace("ID",this.parentNode.dataset.src)),e.setAttribute("frameborder","0"),e.setAttribute("allowfullscreen","1"),e.setAttribute("allow","accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture"),this.parentNode.parentNode.replaceChild(e,this.parentNode)}document.addEventListener("DOMContentLoaded",function(){var exclusions=["home-hero__slide"];var e,t,p,u,l,a=document.getElementsByClassName("rll-youtube-player");for(t=0;t<a.length;t++)(e=document.createElement("div")),(u='https://i.ytimg.com/vi/ID/hqdefault.jpg'),(u=u.replace('ID',a[t].dataset.id)),(l=exclusions.some(exclusion=>u.includes(exclusion))),e.setAttribute("data-id",a[t].dataset.id),e.setAttribute("data-query",a[t].dataset.query),e.setAttribute("data-src",a[t].dataset.src),(e.innerHTML=lazyLoadThumb(a[t].dataset.id,a[t].dataset.alt,l)),a[t].appendChild(e),(p=e.querySelector(".play")),(p.onclick=lazyLoadYoutubeIframe)});</script></body> </html>