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Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) | Division of Cancer Prevention
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href="/major-programs/prostate-lung-colorectal-and-ovarian-cancer-screening-trial-plco/grants" hreflang="en">Grants</a> </li> </ul> </li> </ul> </nav> </div> </div> </div> </aside> </div> <main class="main-content col" id="content" role="main"> <section class="section"> <a id="main-content" tabindex="-1"></a> <div data-drupal-messages-fallback class="hidden"></div><div id="block-custom-base-theme-page-title" class="block block-core block-page-title-block"> <div class="content"> <h1 class="title"><span class="field field--name-title field--type-string field--label-hidden">Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO)</span> </h1> </div> </div> <div id="block-custom-base-theme-content" class="block block-system block-system-main-block"> <div class="content"> <article data-history-node-id="919" about="/major-programs/prostate-lung-colorectal-and-ovarian-cancer-screening-trial-plco" class="node node--type-research-area node--view-mode-full clearfix"> <header> </header> <div class="node__content clearfix"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>The <strong>Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial</strong> was a large randomized controlled trial designed and sponsored by the National Cancer Institute (NCI). The goal was to determine the effects of screening on cancer-related mortality and secondary endpoints in men and women aged 55 to 74.</p> <ul> <li><strong>Prostate:</strong> After 13 years of follow-up, there was no evidence of a mortality benefit for organized annual screening compared with opportunistic screening, which forms part of usual care.</li> <li><strong>Lung:</strong> Annual screening with chest radiographs over a 4-year period did not significantly decrease lung cancer mortality compared with usual care.</li> <li><strong>Colorectal:</strong> Screening with flexible sigmoidoscopy was associated with a significant decrease in colorectal-cancer incidence (in both the distal and proximal colon) and mortality (distal colon only)</li> <li><strong>Ovarian:</strong> Among women in the general U.S. population, simultaneous screening with CA-125 and transvaginal ultrasound compared with usual care did not reduce ovarian cancer mortality.</li> </ul> <p>The results of the trial influenced U.S. Preventative Services Task Force guidelines. Data generated by the study continue to be used to answer related crucial questions.</p> <h2 id="cdas">Cancer Data Access System (CDAS)</h2> <p>Additional information about PLCO can be found on the <a href="https://cdas.cancer.gov/plco/">Cancer Data Access System (CDAS)</a> website, including a <a href="https://cdas.cancer.gov/learn/plco/trial-summary/">trial summary</a>.</p> <p>CDAS also serves as a portal for <a href="https://cdas.cancer.gov/datasets/plco/">PLCO datasets</a>, including:</p> <ul> <li>Study data for <a href="https://cdas.cancer.gov/learn/plco/screening/">screening</a>, <a href="https://cdas.cancer.gov/learn/plco/cancer-dx/">diagnosis</a>, <a href="https://cdas.cancer.gov/learn/plco/treatment/">treatment</a>, and <a href="https://cdas.cancer.gov/learn/plco/mortality/">mortality</a> analyses for prostate, lung, colorectal, and ovarian cancers;</li> <li>Study data for incidence and mortality analyses for cancers of <a href="https://cdas.cancer.gov/datasets/plco/102/">14 other common sites</a> of interest;</li> <li><a href="https://cdas.cancer.gov/learn/plco/early-qx/">Questionnaires</a>;</li> <li><a href="https://cdas.cancer.gov/learn/plco/lab-results/">Lab results</a>;</li> <li>Additional data from <a href="https://cdas.cancer.gov/learn/plco/ancillary-studies/">ancillary studies</a>;</li> <li>Chest x-ray and pathology <a href="https://cdas.cancer.gov/learn/plco/images/">images</a>; and</li> <li><a href="https://cdas.cancer.gov/learn/plco/biospecimens/">Biospecimens</a>.</li> </ul> <h2 id="eems">Etiologic and Early Marker Studies (EEMS)</h2> <p>Over the course of the PLCO trial, over 2.9 million biospecimens were collected, including blood samples, buccal cells, and tumor tissue cores and microarrays. Biospecimens are available to qualified researchers through the <a href="https://cdas.cancer.gov/learn/plco/instructions/?type=eems">Etiologic and Early Marker Studies (EEMS)</a> program. Details of the review process and application materials are available on CDAS.</p> <h2 id="atlas">PLCO Atlas</h2> <p>The cohort of PLCO participants has been followed for more than two decades, resulting in a rich collection of anthropometric, lifestyle, and disease information, and includes data from several smaller-scale molecular studies. The NCI <a href="https://dceg.cancer.gov/">Division of Cancer Epidemiology and Genetics</a> has genotyped 110,000 PLCO participants and developed <a href="https://exploregwas.cancer.gov/plco-atlas/#/">PLCO Atlas</a> as a resource for genetic studies.</p> <div> <div> <ul> </ul> </div> </div></div> <div class="field field--name-field-boxes field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--regular-row paragraph--view-mode--default _2col-50-50"> <div class="field field--name-field-add-a-box field--type-entity-reference-revisions field--label-hidden paragraph--type--columns__4col row field__items"> <div class="field__item mw-100" style="flex: 1;"> <div class="paragraph paragraph--type--text-box paragraph--view-mode--default box-color-white btn--color--"> <div class="clearfix text-formatted field field--name-field-body-no-summary field--type-text-long field--label-hidden field__item"><h2>Funding Opportunity</h2> <p><strong>One FOA is open for application:</strong> Utilizing the PLCO Biospecimens Resource to Bridge Gaps in Cancer Etiology and Early Detection Research <a href="https://grants.nih.gov/grants/guide/pa-files/PAR-21-330.html">PAR-21-330</a> (U01 Clinical Trial Not Allowed)</p> <p>Applications must include a letter confirming the availability of biospecimens. This letter can be requested through <a href="https://cdas.cancer.gov/learn/plco/instructions/?type=par">CDAS</a>.</p> <p>Applications are accepted three times a year. For more information, please refer to the <a href="https://grants.nih.gov/grants/guide/pa-files/PAR-21-330.html">Funding Opportunity Announcement</a> and <a href="https://cdas.cancer.gov/learn/plco/instructions/?type=par">CDAS</a>.</p> <p><strong>FOA expiration date:</strong> October 12, 2024</p></div> </div> </div> <div class="field__item mw-100" style="flex: 1;"> <div class="paragraph paragraph--type--text-box paragraph--view-mode--default box-color-white btn--color--"> <div class="clearfix text-formatted field field--name-field-body-no-summary field--type-text-long field--label-hidden field__item"><h2>EEMS Application for Biospecimens</h2> <p>Applications are accepted twice per year. An approved preliminary application is required before submission of a full application.</p> <p>More details, including deadlines and application instructions, are available on the <a href="https://cdas.cancer.gov/learn/plco/instructions/?type=eems">CDAS</a> website.</p></div> </div> </div> <div class="field__item mw-100" style="flex: 1;"> <div class="paragraph paragraph--type--text-box paragraph--view-mode--default box-color-white btn--color--"> <div class="clearfix text-formatted field field--name-field-body-no-summary field--type-text-long field--label-hidden field__item"><h2>Webinar on PAR 21-330</h2> <p>Utilizing the PLCO Biospecimens Resource to Bridge Gaps in Cancer Etiology and Early Detection Research (U01 Clinical Trial Not Allowed)</p> <p><strong>Date</strong>: May 4, 2022<br> <strong>Presented by</strong>: <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="87ed5fa7-6f94-4fd7-b283-4976673cd28c" href="/about-dcp/staff-search/claire-zhu-ph.d." title="Claire Zhu, Ph.D.">Claire Zhu, Ph.D.</a></p> <p><span><a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="eda7aa4c-c2e6-4b0b-b784-2a02949db077" href="/news-and-events/videos-and-webinars/plco-par-21-330-webinar" title="PLCO PAR-21-330 Webinar">View the Webinar</a></span></p> <div class="smallfont">(RUNTIME: 00:17:46)</div> <p> <span data-document-link-text="Download slides" data-embed-button="document_embed" data-entity-embed-display="view_mode:media.full" data-entity-type="media" data-entity-uuid="4705b2db-5115-47f7-9ccd-a0d4da273c3d" data-langcode="en" data-entity-embed-display-settings="[]" class="embedded-entity"><span media-view-mode="full"> <span class="field field--name-field-media-document field--type-file field--label-hidden field__item"> <span class="file file--mime-application-pdf file--application-pdf" data-document-link-text="Download slides"><a href="/sites/default/files/2023-03/PLCO-PAR-Webinar-20220504.pdf" type="application/pdf">Download slides</a> (PDF, 3.09 MB)</span></span> </span></span> </p></div> </div> </div> <div class="field__item mw-100" style="flex: 1;"> <div class="paragraph paragraph--type--text-box paragraph--view-mode--default box-color-white btn--color--"> <div class="clearfix text-formatted field field--name-field-body-no-summary field--type-text-long field--label-hidden field__item"><h2>Grant Portfolio</h2> <ul> <li>View <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="cbd8e014-30f0-4e1f-b378-02f01faed533" href="/major-programs/prostate-lung-colorectal-and-ovarian-cancer-screening-trial-plco/grants" title="Grants">Active PLCO Research Grants</a></li> </ul> <p> </p> <h2>PLCO Publications</h2> <ul> <li>View PLCO's publications on the <a href="/resources/publication-search#/?b_start=0&b_size=50&sort_on=date_author&all_dates=&SearchableText=&title=&author=&researchGroups=%7B"query"%3A%5B"PLCO"%5D,"operator"%3A"or"%7D">Publications 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