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property="name">Biopharma Asia</span></a><meta property="position" content="1"></span> > <span property="itemListElement" typeof="ListItem"><a property="item" typeof="WebPage" title="Go to Sections." href="https://biopharma-asia.com/sections/" class="archive post-section-archive"><span property="name">Sections</span></a><meta property="position" content="2"></span> > <span property="itemListElement" typeof="ListItem"><a property="item" typeof="WebPage" title="Go to Lilly’s tirzepatide reduces the risk of worsening heart failure events by 38% in adults with heart failure." href="https://biopharma-asia.com/sections/lillys-tirzepatide-reduces-the-risk-of-worsening-heart-failure-events-by-38-in-adults-with-heart-failure/" class="post post-section current-item"><span property="name">Lilly’s tirzepatide reduces the risk of worsening heart failure events by 38% in adults with heart failure</span></a><meta property="position" content="3"></span> </div> </div> </div> </div> <section class="main-content"> <div class="container"> <div class="row"> <div class="col-sm-12"> <div class="row"> <div class="col-md-9"> <div id="hero"> <div class="gallery-item"> <a href="https://cytiva.link/zfht6" target="_blank" class="ad-main-slider-1"> <img src="https://biopharma-asia.com/wp-content/uploads/2024/10/4069_CYTIVA-Palltronic-website-Banner-940X300PX_V1.png" class="img-responsive"> </a> </div> </div> <h1 class="bold">Lilly’s tirzepatide reduces the risk of worsening heart failure events by 38% in adults with heart failure</h1> <div class="blog-post-date"> <p> <em>Posted on November 19, 2024</em> </p> </div> <p>Eli Lilly releases their new detailed results from the SUMMIT Phase 3 trial showing tirzepatide significantly reduced the risk of worsening heart failure events in adults with heart failure with preserved ejection fraction and obesity. Patients treated with tirzepatide also experienced notable improvements in heart failure symptoms and physical limitations.</p> <p>Both of the primary endpoints were met. Tirzepatide showed a 38% reduction in the risk of heart failure outcomes, assessed as a composite endpoint, compared to placebo. Risk of hospitalization for heart failure was reduced by 56%. In addition, patients taking tirzepatide saw a nearly 25-point improvement in the Kansas City Cardiomyopathy Questionnaire Clinical Summary Score聽which measures symptoms and physical limitations associated with heart failure, compared to a 15-point improvement for the placebo group.</p> <p>“Many studies point to obesity as a major contributor to the development and severity of heart failure with a preserved ejection fraction through its effects to promote systemic and myocardial inflammation,” said聽Milton Packer, M.D., distinguished scholar in cardiovascular science at聽Baylor University Medical Center聽at聽Dallas聽and visiting professor at聽Imperial College, London聽(steering committee chair). “The SUMMIT trial provides important insights as to how healthcare providers could have a meaningful impact on the clinical course and quality of life of patients with HFpEF and obesity.”</p> <p>Note that, all key secondary endpoints were also met, with patients treated with tirzepatide demonstrating improved exercise capacity, walking approximately 30 meters farther in six minutes than those on placebo. Additionally, patients treated with tirzepatide saw an average reduction in body weight of 15.7%, compared to 2.2% in the placebo group.聽Tirzepatide also significantly decreased high-sensitivity C-reactive protein, a key marker of systemic inflammation, by 43.4%, while the placebo group saw a 3.5% decrease.</p> <hr> <div class='apss-social-share apss-theme-1 clearfix '> <div class='apss-facebook apss-single-icon'> <a rel='nofollow' title="Share on Facebook" target='_blank' href='https://www.facebook.com/sharer/sharer.php?u=https://biopharma-asia.com/sections/lillys-tirzepatide-reduces-the-risk-of-worsening-heart-failure-events-by-38-in-adults-with-heart-failure/'> <div class='apss-icon-block clearfix'> <i class='fab fa-facebook-f'></i> <span class='apss-social-text'>Share on Facebook</span> <span class='apss-share'>Share</span> </div> </a> </div> <div class='apss-twitter apss-single-icon'> <a rel='nofollow' href="https://twitter.com/intent/tweet?text=Lilly%27s%20tirzepatide%20reduces%20the%20risk%20of%20worsening%20heart%20failure%20events%20by%2038%25%20in%20adults%20with%20heart%20failure&url=https://biopharma-asia.com/sections/lillys-tirzepatide-reduces-the-risk-of-worsening-heart-failure-events-by-38-in-adults-with-heart-failure/&" title='Share on Twitter' target='_blank'> <div class='apss-icon-block clearfix'> <i class='fab fa-twitter'></i> <span class='apss-social-text'>Share on Twitter</span><span class='apss-share'>Tweet</span> </div> </a> </div> <div class='apss-linkedin apss-single-icon'> <a rel='nofollow' title='Share on LinkedIn' target='_blank' href='http://www.linkedin.com/sharing/share-offsite/?url=https://biopharma-asia.com/sections/lillys-tirzepatide-reduces-the-risk-of-worsening-heart-failure-events-by-38-in-adults-with-heart-failure/'> <div class='apss-icon-block clearfix'><i class='fab fa-linkedin'></i> <span class='apss-social-text'>Share on LinkedIn</span> <span class='apss-share'>Share</span> </div> </a> </div> </div> <hr> <h1 class="bold">Related Topics and Keywords </h1><p><a href="https://biopharma-asia.com/tag/hfpef-and-obesity/" rel="tag">(HFpEF) and obesity</a>, <a href="https://biopharma-asia.com/tag/elli-lilly/" rel="tag">elli lilly</a>, <a href="https://biopharma-asia.com/tag/lillys-tirzepatide/" rel="tag">Lilly's tirzepatide</a>, <a href="https://biopharma-asia.com/tag/summit-tehraputics/" rel="tag">summit tehraputics</a>, <a href="https://biopharma-asia.com/tag/summit-trial/" rel="tag">summit trial</a></p> <div id="signup-form"> <h3><strong>Subscribe to our FREE newsletter and WEBINAR UPDATES</strong></h3> <p class="red"><strong>We will not sell or give your information to a third party. 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