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<div class="text-muted"> An Entity of Type: <a href="http://dbpedia.org/ontology/ChemicalSubstance">chemical substance</a>, from Named Graph: <a href="http://dbpedia.org">http://dbpedia.org</a>, within Data Space: <a href="http://dbpedia.org">dbpedia.org</a> </div> </div> </div> <div class="row pt-2"> <div class="col-xs-9 col-sm-10"> Paliperidone, sold under the trade name Invega among others, is an atypical antipsychotic. It is mainly used to treat schizophrenia and schizoaffective disorder. It is marketed by Janssen Pharmaceuticals. An extended release formulation is available that uses the OROS extended release system to allow for once-daily dosing. Paliperidone palmitate is a long-acting injectable formulation of paliperidone palmitoyl ester. It is on the World Health Organization's List of Essential Medicines. </div> <div class="col-xs-3 col-sm-2"> <a href="#" class="thumbnail"> <img src="http://commons.wikimedia.org/wiki/Special:FilePath/Paliperidone.svg?width=300" alt="thumbnail" class="img-fluid" /> </a> </div> </div> </div> </section>   <section> <div class="container-xl"> <div class="row"> <div class="table-responsive"> <table class="table table-hover table-sm table-light"> <thead> <tr> <th class="col-xs-3 ">Property</th> <th class="col-xs-9 px-3">Value</th> </tr> </thead> <tbody> <tr class="odd"><td class="col-2"><a class="uri" href="http://dbpedia.org/ontology/abstract">dbo:abstract</a> </td><td class="col-10 text-break"><ul> <li style="display:none;">باليبيريدون (بالإنجليزية: Paliperidone)‏ هو دواء يُستعمل في علاج: * ذهان * اضطراب فصامي عاطفي * اضطراب نفسي (ar)</li> <li style="display:none;">Η παλιπεριδόνη, που πωλείται με την επωνυμία Invega μεταξύ άλλων, είναι . Διατίθεται στο εμπόριο από την . Η παλιπεριδόνη είναι ο κύριος ενεργός μεταβολίτης του παλαιότερου αντιψυχωσικού ρισπεριδόνη. Ενώ ο μηχανισμός δράσης είναι άγνωστος, θεωρείται ότι η παλιπεριδόνη και η ρισπεριδόνη δρουν με παρόμοιο, αν όχι ίδιο, μηχανισμό. Το Invega είναι ένα παρασκεύασμα παρατεταμένης αποδέσμευσης της παλιπεριδόνης που χρησιμοποιεί το σύστημα παρατεταμένης αποδέσμευσης OROS για να επιτρέπει τη χορήγηση μιας φορά την ημέρα. Η παλιπεριδόνη χρησιμοποιείται κυρίως για τη θεραπεία της σχιζοφρένειας και της σχιζοσυναισθηματικής διαταραχής.Η παλμιτική παλιπεριδόνη είναι ένα ενέσιμο παρασκεύασμα μακράς δράσης παλμιτοϋλ εστέρα παλιπεριδόνης που ενδείκνυται για ένεση μία φορά κάθε 28 ημέρες μετά από μια αρχική περίοδο τιτλοποίησης. Χρησιμοποιείται για τη θεραπεία της σχιζοφρένειας και της σχιζοσυναισθηματικής διαταραχής. Σε μια μελέτη του 2013 που συνέκρινε 15 αντιψυχωσικά φάρμακα στην αποτελεσματικότητα στη θεραπεία των σχιζοφρενικών συμπτωμάτων, η παλιπεριδόνη κατατάχθηκε στην πέμπτη θέση και έδειξε αποτελεσματικότητα υψηλού επιπέδου. Ήταν 10-14% πιο αποτελεσματική από την αλοπεριδόλη, την κουετιαπίνη και την αριπιπραζόλη, 11% λιγότερο αποτελεσματική από τη ρισπεριδόνη (4η) και 43% λιγότερο αποτελεσματική από την κλοζαπίνη (1η). (el)</li> <li style="display:none;">Paliperidon ist ein Arzneistoff aus der Gruppe der atypischen Neuroleptika. Unter dem Handelsnamen Invega (Janssen Pharmaceutica) ist er seit 2007 in Form von Retardtabletten und als Xeplion und Trevicta in intramuskulärer Depotform seit 2011 in der Europäischen Union zugelassen für die Behandlung der Schizophrenie. Die Verabreichung der Depotform erhöht die Kontrolle der kontinuierlichen Einnahme des Medikaments. Dies ist insofern wichtig, als Neuroleptika für die Therapie einiger schwerer psychischer Erkrankungen eingesetzt werden, von den Patienten aber oftmals mangels Einsicht nach einiger Zeit wieder abgesetzt werden. Gleichzeitig vereinfacht die Depotform den Alltag für die Betroffenen, da die tägliche Einnahme und die damit verbundenen Spiegelschwankungen wegfallen. Nachteilig gegenüber der Tablettenform ist hingegen der Aspekt, dass der Wirkstoff beim Auftreten von schwerwiegenden Nebenwirkungen noch längere Zeit im Blut verweilt und die Wirkung somit noch längere Zeit anhält. (de)</li> <li>Paliperidone, sold under the trade name Invega among others, is an atypical antipsychotic. It is mainly used to treat schizophrenia and schizoaffective disorder. It is marketed by Janssen Pharmaceuticals. An extended release formulation is available that uses the OROS extended release system to allow for once-daily dosing. Paliperidone palmitate is a long-acting injectable formulation of paliperidone palmitoyl ester. It is on the World Health Organization's List of Essential Medicines. (en)</li> <li style="display:none;">パリペリドン（英語: Paliperidone）は、非定型抗精神病薬であり、リスペリドンの活性代謝物（9-ヒドロキシリスペリドン）である。両成分は、共にヤンセンファーマ社から発売されている。 2006年12月20日にアメリカ食品医薬品局 (FDA) に統合失調症の治療薬として承認された。日本では2011年より、ヤンセンファーマから錠剤がインヴェガ (Invega)、注射剤がゼプリオン (Xeplion) として販売された。統合失調症の他に、アメリカ合衆国では統合失調感情障害にも適応症がある。 2014年には、ゼプリオン水懸筋注を使用中の患者の複数の死亡症例（ただし因果関係は不明）から厚生労働省より安全性速報が出され、使用上の注意が改定された。 (ja)</li> <li style="display:none;">Il Paliperidone, chiamato anche Invega, è un farmaco che viene usato per la schizofrenia e il disturbo schizoaffettivo; appartiene alla categoria farmacologica degli antipsicotici atipici ed è il metabolita attivo di un altro antipsicotico, il risperidone. Oltre che nella formulazione per uso orale, è disponibile sotto forma di iniezione intramuscolo mensile, con il nome commerciale di Xeplion e in quella trimestrale, con il nome di Trevicta. (it)</li> <li style="display:none;">Paliperidon is een geneesmiddel voor de behandeling van schizofrenie dat op de markt wordt gebracht door onder de merknaam Invega. Het is ontwikkeld bij Janssen Pharmaceutica als een doorontwikkeling van het langer bestaande antipsychoticum risperidon, ook van Janssen Pharmaceutica. Paliperidon maakt gebruik van een type tabletten met een speciaal mechanisme (de zogenaamde OROS-technologie). Door dat mechanisme wordt de werkzame stof gelijkmatig over de hele dag aan het lichaam afgegeven. Dat moet ervoor zorgen dat het geneesmiddel tegelijk effectief is en minder bijwerkingen geeft. (nl)</li> <li style="display:none;">팔리페리돈(Paliperidone)은 미국 존슨앤드존슨 산하의 얀센실라그(Janssen-Cilag)에서 개발 및 출시하여 조현병, 조울증에 사용되는 비정형적 항정신병제제이다. 상품명으로 '인베가(Invega)' 등이 사용된다. 삼투압 현상을 이용해 약물 흡수 속도를 조절하는 기술(Osmotic Release Oral Delivery System)을 응용해, 약물이 서서히 방출되어, 장에서 흡수되는 장용성 서방형 제제(OROS 제법)로 설계되었다. (ko)</li> <li style="display:none;">Paliperydon, paliperidon – wielofunkcyjny organiczny związek chemiczny, hydroksylowa pochodna rysperydonu (którego jest aktywnym metabolitem). Stosuje się go jako lek przeciwpsychotyczny drugiej generacji w leczeniu schizofrenii, choroby afektywnej dwubiegunowej i zaburzenia schizoafektywnego. Opracowano też iniekcje o przedłużonym uwalnianiu, zawierające palmitynian paliperydonu. Paliperydon jest antagonistą dopaminy i serotoniny, działając głównie na D2 i serotoninergiczne 5HT2A, 5HT7. Ma też własności antagonistyczne w stosunku do receptorów adrenergicznych α1 i α2. Nie ma powinowactwa do receptorów muskarynowych, w związku z czym nie wywiera istotnego klinicznie działania antycholinergicznego. (pl)</li> <li style="display:none;">Палиперидон (Инвега, Ксеплион, Тревикта) — атипичный антипсихотический препарат, разработанный компанией . Является метаболитом препарата рисперидон (9-гидроксирисперидон), отличаясь от него наличием одной гидроксильной группы. Вследствие этого предположительный механизм действия препарата аналогичен механизму действия рисперидона, хотя в точности он ещё не изучен. Агентство FDA одобрило палиперидон к применению при шизофрении и биполярном расстройстве 20 декабря 2006 года. В 2011 году зарегистрирован для применения при шизоаффективном расстройстве. Палиперидон выпускается в таблетках, также существует инъекционная пролонгированная форма палиперидона (палиперидона пальмитат) под торговым названием «Ксеплион». (ru)</li> <li style="display:none;">Paliperidon (såld med varunamnet Invega) är ett atypiskt antipsykotikum. Paliperidon marknadsförs som behandling vid schizofreni och bipolär mani. Paliperidon är den aktiva metaboliten 9-hydroxyrisperidon av risperidon. Det är tveksamt om paliperidon har några fördelar jämfört med risperidon ur effekt- eller biverkningssynpunkt. Patentet har gått ut. (sv)</li> <li style="display:none;">Паліперидон (англ. Paliperidone, лат. Paliperidonum) — синтетичний лікарський засіб, що є похідним та активним метаболітом іншого антипсихотичного препарату — рисперидону. Паліперидон застосовується як перорально, так і внутрішньом'язово. Паліперидон розроблений у лабораторії компанії «Janssen Pharmaceutica», та застосовується у клінічній практиці з 2006 року. (uk)</li> <li style="display:none;">帕利哌酮（英語：Paliperidone）是一种多巴胺和，属于非典型抗精神失常药。帕利哌酮由杨森制药销售，口服剂型为控释剂，一天服用一次。商品名為Invega，是採用的藥物。帕利哌酮棕櫚酸酯用於長效注射，在注射後每次可維持28天。 (zh)</li> </ul></td></tr><tr class="even"><td class="col-2"><a class="uri" href="http://dbpedia.org/ontology/alternativeName">dbo:alternativeName</a> </td><td class="col-10 text-break"><ul> <li>Invega, Xeplion, Trevicta, others (en)</li> </ul></td></tr><tr class="odd"><td class="col-2"><a class="uri" href="http://dbpedia.org/ontology/bioavailability">dbo:bioavailability</a> </td><td class="col-10 text-break"><ul> <li>28.000000 (xsd:float)</li> </ul></td></tr><tr class="even"><td class="col-2"><a class="uri" href="http://dbpedia.org/ontology/casNumber">dbo:casNumber</a> </td><td class="col-10 text-break"><ul> <li>144598-75-4</li> </ul></td></tr><tr class="odd"><td class="col-2"><a class="uri" href="http://dbpedia.org/ontology/chEBI">dbo:chEBI</a> </td><td class="col-10 text-break"><ul> <li>82978</li> </ul></td></tr><tr class="even"><td 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href="http://www.w3.org/2000/01/rdf-schema#comment">rdfs:comment</a> </td><td class="col-10 text-break"><ul> <li style="display:none;">باليبيريدون (بالإنجليزية: Paliperidone)‏ هو دواء يُستعمل في علاج: * ذهان * اضطراب فصامي عاطفي * اضطراب نفسي (ar)</li> <li>Paliperidone, sold under the trade name Invega among others, is an atypical antipsychotic. It is mainly used to treat schizophrenia and schizoaffective disorder. It is marketed by Janssen Pharmaceuticals. An extended release formulation is available that uses the OROS extended release system to allow for once-daily dosing. Paliperidone palmitate is a long-acting injectable formulation of paliperidone palmitoyl ester. It is on the World Health Organization's List of Essential Medicines. (en)</li> <li style="display:none;">パリペリドン（英語: Paliperidone）は、非定型抗精神病薬であり、リスペリドンの活性代謝物（9-ヒドロキシリスペリドン）である。両成分は、共にヤンセンファーマ社から発売されている。 2006年12月20日にアメリカ食品医薬品局 (FDA) に統合失調症の治療薬として承認された。日本では2011年より、ヤンセンファーマから錠剤がインヴェガ (Invega)、注射剤がゼプリオン (Xeplion) として販売された。統合失調症の他に、アメリカ合衆国では統合失調感情障害にも適応症がある。 2014年には、ゼプリオン水懸筋注を使用中の患者の複数の死亡症例（ただし因果関係は不明）から厚生労働省より安全性速報が出され、使用上の注意が改定された。 (ja)</li> <li style="display:none;">Il Paliperidone, chiamato anche Invega, è un farmaco che viene usato per la schizofrenia e il disturbo schizoaffettivo; appartiene alla categoria farmacologica degli antipsicotici atipici ed è il metabolita attivo di un altro antipsicotico, il risperidone. Oltre che nella formulazione per uso orale, è disponibile sotto forma di iniezione intramuscolo mensile, con il nome commerciale di Xeplion e in quella trimestrale, con il nome di Trevicta. (it)</li> <li style="display:none;">Paliperidon is een geneesmiddel voor de behandeling van schizofrenie dat op de markt wordt gebracht door onder de merknaam Invega. Het is ontwikkeld bij Janssen Pharmaceutica als een doorontwikkeling van het langer bestaande antipsychoticum risperidon, ook van Janssen Pharmaceutica. Paliperidon maakt gebruik van een type tabletten met een speciaal mechanisme (de zogenaamde OROS-technologie). Door dat mechanisme wordt de werkzame stof gelijkmatig over de hele dag aan het lichaam afgegeven. Dat moet ervoor zorgen dat het geneesmiddel tegelijk effectief is en minder bijwerkingen geeft. (nl)</li> <li style="display:none;">팔리페리돈(Paliperidone)은 미국 존슨앤드존슨 산하의 얀센실라그(Janssen-Cilag)에서 개발 및 출시하여 조현병, 조울증에 사용되는 비정형적 항정신병제제이다. 상품명으로 '인베가(Invega)' 등이 사용된다. 삼투압 현상을 이용해 약물 흡수 속도를 조절하는 기술(Osmotic Release Oral Delivery System)을 응용해, 약물이 서서히 방출되어, 장에서 흡수되는 장용성 서방형 제제(OROS 제법)로 설계되었다. (ko)</li> <li style="display:none;">Палиперидон (Инвега, Ксеплион, Тревикта) — атипичный антипсихотический препарат, разработанный компанией . Является метаболитом препарата рисперидон (9-гидроксирисперидон), отличаясь от него наличием одной гидроксильной группы. Вследствие этого предположительный механизм действия препарата аналогичен механизму действия рисперидона, хотя в точности он ещё не изучен. Агентство FDA одобрило палиперидон к применению при шизофрении и биполярном расстройстве 20 декабря 2006 года. В 2011 году зарегистрирован для применения при шизоаффективном расстройстве. Палиперидон выпускается в таблетках, также существует инъекционная пролонгированная форма палиперидона (палиперидона пальмитат) под торговым названием «Ксеплион». (ru)</li> <li style="display:none;">Paliperidon (såld med varunamnet Invega) är ett atypiskt antipsykotikum. Paliperidon marknadsförs som behandling vid schizofreni och bipolär mani. Paliperidon är den aktiva metaboliten 9-hydroxyrisperidon av risperidon. Det är tveksamt om paliperidon har några fördelar jämfört med risperidon ur effekt- eller biverkningssynpunkt. Patentet har gått ut. (sv)</li> <li style="display:none;">Паліперидон (англ. Paliperidone, лат. Paliperidonum) — синтетичний лікарський засіб, що є похідним та активним метаболітом іншого антипсихотичного препарату — рисперидону. Паліперидон застосовується як перорально, так і внутрішньом'язово. Паліперидон розроблений у лабораторії компанії «Janssen Pharmaceutica», та застосовується у клінічній практиці з 2006 року. (uk)</li> <li style="display:none;">帕利哌酮（英語：Paliperidone）是一种多巴胺和，属于非典型抗精神失常药。帕利哌酮由杨森制药销售，口服剂型为控释剂，一天服用一次。商品名為Invega，是採用的藥物。帕利哌酮棕櫚酸酯用於長效注射，在注射後每次可維持28天。 (zh)</li> <li style="display:none;">Η παλιπεριδόνη, που πωλείται με την επωνυμία Invega μεταξύ άλλων, είναι . Διατίθεται στο εμπόριο από την . Η παλιπεριδόνη είναι ο κύριος ενεργός μεταβολίτης του παλαιότερου αντιψυχωσικού ρισπεριδόνη. Ενώ ο μηχανισμός δράσης είναι άγνωστος, θεωρείται ότι η παλιπεριδόνη και η ρισπεριδόνη δρουν με παρόμοιο, αν όχι ίδιο, μηχανισμό. (el)</li> <li style="display:none;">Paliperidon ist ein Arzneistoff aus der Gruppe der atypischen Neuroleptika. Unter dem Handelsnamen Invega (Janssen Pharmaceutica) ist er seit 2007 in Form von Retardtabletten und als Xeplion und Trevicta in intramuskulärer Depotform seit 2011 in der Europäischen Union zugelassen für die Behandlung der Schizophrenie. (de)</li> <li style="display:none;">Paliperydon, paliperidon – wielofunkcyjny organiczny związek chemiczny, hydroksylowa pochodna rysperydonu (którego jest aktywnym metabolitem). Stosuje się go jako lek przeciwpsychotyczny drugiej generacji w leczeniu schizofrenii, choroby afektywnej dwubiegunowej i zaburzenia schizoafektywnego. Opracowano też iniekcje o przedłużonym uwalnianiu, zawierające palmitynian paliperydonu. (pl)</li> </ul></td></tr><tr class="odd"><td class="col-2"><a class="uri" href="http://www.w3.org/2000/01/rdf-schema#label">rdfs:label</a> </td><td class="col-10 text-break"><ul> <li style="display:none;">باليبيريدون (ar)</li> <li style="display:none;">Paliperidon (de)</li> <li style="display:none;">Παλιπεριδόνη (el)</li> <li style="display:none;">Paliperidone (it)</li> <li style="display:none;">팔리페리돈 (ko)</li> <li style="display:none;">パリペリドン (ja)</li> <li>Paliperidone (en)</li> <li style="display:none;">Paliperydon (pl)</li> <li style="display:none;">Paliperidon (nl)</li> <li style="display:none;">Палиперидон (ru)</li> <li style="display:none;">Paliperidon (sv)</li> <li style="display:none;">帕利哌酮 (zh)</li> <li style="display:none;">Паліперидон (uk)</li> </ul></td></tr><tr class="even"><td class="col-2"><a class="uri" href="http://www.w3.org/2002/07/owl#sameAs">owl:sameAs</a> </td><td class="col-10 text-break"><ul> <li><a class="uri" rel="owl:sameAs" 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