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Research Papers | Innovation | Ajinomoto Group Global Website - Eat Well, Live Well.

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method="get" role="search"><input type="text" title="Type search word here" name="pb_kw" tabindex="0" placeholder="Search Here" class="header-search__input"><button type="submit" tabindex="-1" class="header-search__submit"><img src="/assets/img/ico_search.svg" width="16" height="16" alt="Search" /></button></form> </header> <!-- //header --> <!-- main --> <main class="main"> <nav class='p-breadcrumbs' style=''><ul class='p-breadcrumbs__list' itemscope itemtype='https://schema.org/BreadcrumbList'><li class='p-breadcrumbs__item' itemprop='itemListElement' itemscope itemtype='https://schema.org/ListItem'><a href='https://www.ajinomoto.com' class='p-breadcrumbs__link' itemprop='item'><span itemprop='name'>Home</span></a><meta itemprop='position' content='1' /></li><li class='p-breadcrumbs__item' itemprop='itemListElement' itemscope itemtype='https://schema.org/ListItem'><a href='https://www.ajinomoto.com/innovation' class='p-breadcrumbs__link' itemprop='item'><span itemprop='name'>Innovation</span></a><meta itemprop='position' content='2' /></li><li class='p-breadcrumbs__item' itemprop='itemListElement' itemscope itemtype='https://schema.org/ListItem'><span class='p-breadcrumbs__link' itemprop='name'>Research Papers</span><meta itemprop='position' content='3' /></li></ul></nav><div class="innovation--container"> <main class="main"> <h1 class="inv_mv"> <picture class="inv_mv__image"> <source media="(min-width:750px)" srcset="/assets/innovation/img/recr/inv_mv_pc.jpg" width="1920" height="400"><img src="/assets/innovation/img/recr/inv_mv_sp.jpg" width="760" height="500" alt="Research Papers"> </picture><span class="inv_mv__text">Research Papers</span> </h1> <div class="inv_recrcopy jsFadein js-scrl"> <div class="container--narrow"> <p class="inv_txt">For over 100 years since the discovery of umami substances, we have explored the possibilities of amino acids. We carry out R&D activities in a wide range of fields centered around "AminoScience," an approach developed through many years of research on amino acids. See below for a list of academic papers where our results have been published.</p> </div> </div> <div class="inv_recr"> <div class="container--narrow"> <div class="inv_recr__tablist jsFadein js-scrl"> <button class="inv_recr__tab js-tab" type="button" aria-controls="year-2020">2020</button> <button class="inv_recr__tab js-tab" type="button" aria-controls="year-2021">2021</button> <button class="inv_recr__tab js-tab" type="button" aria-controls="year-2022">2022</button> <button class="inv_recr__tab js-tab is-active" type="button" aria-controls="year-2023">2023</button> </div> <div class="inv_recr__content jsFadein js-scrl"> <div class="inv_recr__tabcontent" id="year-2020"> <ul class="inv_recrlist"> <li> <p class="inv_recrlist__title">Association between soup consumption and obesity: A systematic review with meta-analysis </p> <p class="inv_recrlist__info">Physiology and Behavior, 2020, 225, 113103 </p> </li> <li> <p class="inv_recrlist__title">Effects of capsinoid intake on brown adipose tissue vascular density and resting energy expenditure in healthy, middle‐aged adults: A randomized, double‐blind, placebo‐controlled study </p> <p class="inv_recrlist__info">Nutrients, 2020, 12 (9), 2676, 1-14 </p> </li> <li> <p class="inv_recrlist__title">Synthesis and Biological Evaluation of Antibody Drug Conjugates Based on an Antibody Expression System: Conamax </p> <p class="inv_recrlist__info">ACS Omega, 2020, 5 (13), 7193-7200 </p> </li> <li> <p class="inv_recrlist__title">Insight into Temperature Dependency and Design of Experiments towards Process Development for Cysteine-Based Antibody-Drug Conjugates </p> <p class="inv_recrlist__info">ChemistrySelect, 2020, 5 (28), 8435-8439 </p> </li> <li> <p class="inv_recrlist__title">Characterization of newly developed pepper cultivars (Capsicum chinense) ‘Dieta0011-0301’, ‘Dieta0011-0602’, ‘Dieta0041-0401’, and ‘Dieta0041-0601’ containing high capsinoid concentrations and a strong fruity aroma </p> <p class="inv_recrlist__info">Bioscience, Biotechnology and Biochemistry, 2020, 84 (9), 1870-1885 </p> </li> <li> <p class="inv_recrlist__title">Feeding rumen-protected lysine prepartum increases energy-corrected milk and milk component yields in Holstein cows during early lactation </p> <p class="inv_recrlist__info">Journal of Dairy Science, 2020, 103 (12), 11386-11400 </p> </li> <li> <p class="inv_recrlist__title">L-serine and EPA relieve chronic low-back and knee pain in adults: A randomized, double-blind, placebo-controlled trial </p> <p class="inv_recrlist__info">Journal of Nutrition, 2020, 150 (9), 2278-2286 </p> </li> <li> <p class="inv_recrlist__title">Structure–Activity Relationship Study of T1R2/T1R3 Positive Allosteric Modulators and Evaluation of Their Enhancing Effect on Various Sweeteners </p> <p class="inv_recrlist__info">ChemistrySelect, 2020, 5 (30), 9457-9460 </p> </li> <li> <p class="inv_recrlist__title">The effect of leucine-enriched essential amino acid supplementation on anabolic and catabolic signaling in human skeletal muscle after acute resistance exercise: A randomized, double-blind, placebo-controlled, parallel-group comparison trial </p> <p class="inv_recrlist__info">Nutrients, 2020, 12 (8), 2421, 1-15 </p> </li> <li> <p class="inv_recrlist__title">Characterization of the Corynebacterium glutamicum dehydroshikimate dehydratase QsuB and its potential for microbial production of protocatechuic acid </p> <p class="inv_recrlist__info">PLoS ONE, 2020, 15 (8 August), e0231560 </p> </li> <li> <p class="inv_recrlist__title">Histidine: A systematic review on metabolism and physiological effects in human and different animal species </p> <p class="inv_recrlist__info">Nutrients, 2020, 12 (5), 1414 </p> </li> <li> <p class="inv_recrlist__title">Dispensable amino acids, except glutamine and proline, are ideal nitrogen sources for protein synthesis in the presence of adequate indispensable amino acids in adult men </p> <p class="inv_recrlist__info">Journal of Nutrition, 2020, 150 (9), 2398-2404 </p> </li> <li> <p class="inv_recrlist__title">Nitrogen Balance in Female Japanese National Handball Players During Training Camp </p> <p class="inv_recrlist__info">Frontiers in Nutrition, 2020, 7, 59 </p> </li> <li> <p class="inv_recrlist__title">Use of plasma-free amino acids as biomarkers for detecting and predicting disease risk </p> <p class="inv_recrlist__info">Nutrition Reviews, 2020, 78, 79-85 </p> </li> <li> <p class="inv_recrlist__title">Simultaneous analysis of d, l-amino acids in human urine using a chirality-switchable biaryl axial tag and liquid chromatography electrospray ionization tandem mass spectrometry </p> <p class="inv_recrlist__info">Symmetry, 2020, 12 (6), 913 </p> </li> <li> <p class="inv_recrlist__title">Cdmo case study ajility: Streamlining drug product manufacturing </p> <p class="inv_recrlist__info">Drug Development and Delivery, 2020, 20 (7), 34-37 </p> </li> <li> <p class="inv_recrlist__title">Standardized ileal digestible lysine and valine-to-lysine requirements for optimal performance of 4 to 9-week-old Piétrain cross piglets </p> <p class="inv_recrlist__info">Livestock Science, 2020, 241, 104263 </p> </li> <li> <p class="inv_recrlist__title">The ideal protein profile for late-finishing pigs in precision feeding systems: Threonine </p> <p class="inv_recrlist__info">Animal Feed Science and Technology, 2020, 265, 114500 </p> </li> <li> <p class="inv_recrlist__title">Glutamate metabolism in a human intestinal epithelial cell layer model </p> <p class="inv_recrlist__info">Amino Acids, 2020, 52 (November), 1505-1529 </p> </li> <li> <p class="inv_recrlist__title">Evaluation of a Novel Boron-Containing α-D-Mannopyranoside for BNCT </p> <p class="inv_recrlist__info">Cells, 2020, 9 (5), 1293 </p> </li> <li> <p class="inv_recrlist__title">Genomic characterization of closely related species in the Rumoiensis clade infers ecogenomic signatures to non-marine environments </p> <p class="inv_recrlist__info">Environmental Microbiology, 2020, 22 (8), 3205-3217 </p> </li> <li> <p class="inv_recrlist__title">Forecasting disability-adjusted life years for chronic diseases: Reference and alternative scenarios of salt intake for 2017-2040 in Japan </p> <p class="inv_recrlist__info">BMC Public Health, 2020, 20 (1), 1475 </p> </li> <li> <p class="inv_recrlist__title">Bioavailability of rumen-protected methionine, lysine and histidine assessed by fecal amino acid excretion </p> <p class="inv_recrlist__info">Animal Feed Science and Technology, 2020, 268, 114595 </p> </li> <li> <p class="inv_recrlist__title">Crystal structure of a YeeE/YedE family protein engaged in thiosulfate uptake </p> <p class="inv_recrlist__info">Science Advances, 2020, 6 (35), eaba7637 </p> </li> <li> <p class="inv_recrlist__title">Stereospecific linalool production utilizing two-phase cultivation system in Pantoea ananatis </p> <p class="inv_recrlist__info">Journal of Biotechnology, 2020, 324, 21-27 </p> </li> <li> <p class="inv_recrlist__title">RESEARCH ARTICLE Translational Control of Muscle Mass Leucine-enriched amino acids maintain peripheral mTOR-Rheb localization independent of myofibrillar protein synthesis and mTORC1 signaling postexercise </p> <p class="inv_recrlist__info">Journal of Applied Physiology, 2020, 129 (1), 133-143 </p> </li> <li> <p class="inv_recrlist__title">Leucine-enriched essential amino acids improve recovery from post-exercise muscle damage independent of increases in integrated myofibrillar protein synthesis in young men </p> <p class="inv_recrlist__info">Nutrients, 2020, 12 (4), 1061 </p> </li> <li> <p class="inv_recrlist__title">Production of glutamate and stereospecific flavors, (S)-linalool and (+)-valencene, by Synechocystis sp. PCC6803 </p> <p class="inv_recrlist__info">Journal of Bioscience and Bioengineering, 2020, 130 (5), 464-470 </p> </li> <li> <p class="inv_recrlist__title">Field testing an oil-based Trichoderma asperellum formulation for the biological control of cacao black pod disease, caused by Phytophthora megakarya </p> <p class="inv_recrlist__info">Crop Protection, 2020, 132, 105134 </p> </li> <li> <p class="inv_recrlist__title">Validation of preferred salt concentration in soup based on a randomized blinded experiment in multiple regions in Japan—influence of umami (l-glutamate) on saltiness and palatability of low-salt solutions </p> <p class="inv_recrlist__info">Hypertension Research, 2020, 43 (6), 525-533 </p> </li> <li> <p class="inv_recrlist__title">Metabolome-based discrimination analysis of shallot landraces and bulb onion cultivars associated with differences in the amino acid and flavonoid profiles </p> <p class="inv_recrlist__info">Molecules, 2020, 25 (22), 5300 </p> </li> <li> <p class="inv_recrlist__title">Universal Actuator for Efficient Silencing of Escherichia coli Genes Based on Convergent Transcription Resistant to Rho-Dependent Termination </p> <p class="inv_recrlist__info">ACS Synthetic Biology, 2020, 9 (7), 1650-1664 </p> </li> <li> <p class="inv_recrlist__title">Generation of human induced pluripotent stem cell-derived liver buds with chemically defined and animal origin-free media </p> <p class="inv_recrlist__info">Scientific Reports, 2020, 10 (1), 17937 </p> </li> <li> <p class="inv_recrlist__title">Quantification of the kokumi peptide, γ-glutamyl-valyl-glycine, in cheese: Comparison between cheese made from cow and ewe milk </p> <p class="inv_recrlist__info">Journal of Dairy Science, 2020, 103 (9), 7801-7807 </p> </li> <li> <p class="inv_recrlist__title">Application of Native Ion Exchange Mass Spectrometry to Intact and Subunit Analysis of Site-Specific Antibody-Drug Conjugates Produced by AJICAP First Generation Technology </p> <p class="inv_recrlist__info">Journal of the American Society for Mass Spectrometry, 2020, 31 (8), 1706-1712 </p> </li> <li> <p class="inv_recrlist__title">Intake of Seven Essential Amino Acids Improves Cognitive Function and Psychological and Social Function in Middle-Aged and Older Adults: A Double-Blind, Randomized, Placebo-Controlled Trial </p> <p class="inv_recrlist__info">Frontiers in Nutrition, 2020, 7, 586166 </p> </li> <li> <p class="inv_recrlist__title">Data science-based modeling of the lysine fermentation process </p> <p class="inv_recrlist__info">Journal of Bioscience and Bioengineering, 2020, 130 (4), 409-415 </p> </li> <li> <p class="inv_recrlist__title">Combined Omics Approaches Reveal the Roles of Non-canonical WNT7B Signaling and YY1 in the Proliferation of Human Pancreatic Progenitor Cells </p> <p class="inv_recrlist__info">Cell Chemical Biology, 2020, 27 (12), 1561-1570 </p> </li> <li> <p class="inv_recrlist__title">Erratum to: Validation of preferred salt concentration in soup based on a randomized blinded experiment in multiple regions in Japan—influence of umami (l-glutamate) on saltiness and palatability of low-salt solutions (Hypertension Research, (2020), 43, 6, (525-533), 10.1038/s41440-020-0397-1) </p> <p class="inv_recrlist__info">Hypertension Research, 2020, 43 (6), 579-581 </p> </li> <li> <p class="inv_recrlist__title">Innovation in the food industry using microbial transglutaminase: Keys to success and future prospects </p> <p class="inv_recrlist__info">Analytical Biochemistry, 2020, 597, 113638 </p> </li> <li> <p class="inv_recrlist__title">Design, synthesis and evaluation of unnatural peptides as T1R2/T1R3 PAMs </p> <p class="inv_recrlist__info">Bioorganic and Medicinal Chemistry Letters, 2020, 30 (8), 127000 </p> </li> <li> <p class="inv_recrlist__title">A purification strategy utilizing hydrophobic interaction chromatography to obtain homogeneous species from a site-specific antibody drug conjugate produced by ajicaptm first generation </p> <p class="inv_recrlist__info">Antibodies, 2020, 9 (2), 16 </p> </li> <li> <p class="inv_recrlist__title">Valine requirement of female Cobb broilers from 8 to 21 days of age </p> <p class="inv_recrlist__info">Journal of Applied Poultry Research, 2020, 29 (4), 775-785 </p> </li> <li> <p class="inv_recrlist__title">Fermentative production of sulfur-containing amino acid with engineering putative L-cystathionine and L-cysteine uptake systems in Escherichia coli </p> <p class="inv_recrlist__info">Journal of Bioscience and Bioengineering, 2020, 130 (1), 14-19 </p> </li> <li> <p class="inv_recrlist__title">Plasma branched-chain and aromatic amino acids in relation to hypertension </p> <p class="inv_recrlist__info">Nutrients, 2020, 12 (12), 3791, 1-11 </p> </li> <li> <p class="inv_recrlist__title">Expression of feeding-related neuromodulatory signalling molecules in the mouse central olfactory system </p> <p class="inv_recrlist__info">Scientific Reports, 2020, 10 (1), 890 </p> </li> <li> <p class="inv_recrlist__title">Preoperative AminoIndex Cancer Screening (AICS) abnormalities predict postoperative recurrence in patients undergoing curative resection for non-small cell lung cancer </p> <p class="inv_recrlist__info">BMC Cancer, 2020, 20 (1), 1100 </p> </li> <li> <p class="inv_recrlist__title">Application of inorganic phosphate limitation to efficient isoprene production in Pantoea ananatis </p> <p class="inv_recrlist__info">Journal of Applied Microbiology, 2020, 128 (3), 763-774 </p> </li> <li> <p class="inv_recrlist__title">Proof of site-specificity of antibody-drug conjugates produced by chemical conjugation technology: AJICAP first generation </p> <p class="inv_recrlist__info">Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2020, 1140, 121981 </p> </li> <li> <p class="inv_recrlist__title">Open innovation platform using cloud-based applications and collaborative space: a case study of solubility prediction model development </p> <p class="inv_recrlist__info">Chem-Bio Informatics Journal, 2020, 20, 5-18 </p> </li> <li> <p class="inv_recrlist__title">AJICAP TM: Development of a chemical site-specific conjugation technology for antibody-drug conjugates </p> <p class="inv_recrlist__info">Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, 2020, 78 (5), 495-502 </p> </li> <li> <p class="inv_recrlist__title">A novel one-step method for targeted multiplication of DNA fragments from the Escherichia coli chromosome mediated by coordinated functioning of λ and φ80 bacteriophage recombination systems </p> <p class="inv_recrlist__info">Journal of Microbiological Methods, 2020, 170, 105842 </p> </li> <li> <p class="inv_recrlist__title">Efficiency of standardized ileal digestible lysine utilization for whole body protein deposition in pregnant gilts and sows during early-, mid-, and late-gestation </p> <p class="inv_recrlist__info">Journal of Animal Science, 2020, 98 (11), skaa340 </p> </li> <li> <p class="inv_recrlist__title">Comprehensive dipeptide analysis by pre-column derivatization lc/ms/ms </p> <p class="inv_recrlist__info">Bunseki Kagaku, 2020, 69 (4.5), 173-178 </p> </li> <li> <p class="inv_recrlist__title">L-arginine supplementation during the final third of gestation improves litter uniformity and physical characteristics of neonatal piglet thermoregulation </p> <p class="inv_recrlist__info">Journal of Animal Physiology and Animal Nutrition, 2020, 104 (2), 645-656 </p> </li> <li> <p class="inv_recrlist__title">Effects of serial cervical or tail blood sampling on toxicity and toxicokinetic evaluation in rats </p> <p class="inv_recrlist__info">Journal of Toxicological Sciences, 2020, 45 (10), 599-609 </p> </li> <li> <p class="inv_recrlist__title">Development of an LC-NMR system using a diode array detector and a charged aerosol detector </p> <p class="inv_recrlist__info">Bunseki Kagaku, 2020, 69 (3), 151-155 </p> </li> <li> <p class="inv_recrlist__title">Effects on nitrogen balance and metabolism of branched-chain amino acids by growing pigs of supplementing isoleucine and valine to diets with adequate or excess concentrations of dietary leucine </p> <p class="inv_recrlist__info">Journal of Animal Science, 2020, 98 (11), skaa346 </p> </li> <li> <p class="inv_recrlist__title">Regulation of skeletal muscle function by amino acids </p> <p class="inv_recrlist__info">Nutrients, 2020, 12 (1), 261 </p> </li> <li> <p class="inv_recrlist__title">Detection and recognition thresholds for five basic tastes in patients with mild cognitive impairment and Alzheimer's disease dementia </p> <p class="inv_recrlist__info">BMC Neurology, 2020, 20 (1), 110 </p> </li> <li> <p class="inv_recrlist__title">Effects of capsinoids on daily physical activity, body composition and cold hypersensitivity in middle-aged and older adults: A randomized study </p> <p class="inv_recrlist__info">Nutrients, 2020, 12 (1), 212 </p> </li> <li> <p class="inv_recrlist__title">Intake and preference for dried bonito dashi in male Sprague-Dawley rats and C57BL/6 N mice </p> <p class="inv_recrlist__info">Physiology and Behavior, 2020, 213, 112708 </p> </li> <li> <p class="inv_recrlist__title">Protein Deficiency-Induced Behavioral Abnormalities and Neurotransmitter Loss in Aged Mice Are Ameliorated by Essential Amino Acids </p> <p class="inv_recrlist__info">Frontiers in Nutrition, 2020, 7, 23 </p> </li> <li> <p class="inv_recrlist__title">Induction of tryptophan hydroxylase in the liver of s.c. tumor model of prostate cancer </p> <p class="inv_recrlist__info">Cancer Science, 2020, 111 (4), 1218-1227 </p> </li> <li> <p class="inv_recrlist__title">Metabolomic Links between Sugar-Sweetened Beverage Intake and Obesity </p> <p class="inv_recrlist__info">Journal of Obesity, 2020, 2020, 7154738 </p> </li> <li> <p class="inv_recrlist__title">High-transparency adhesive-encapsulation film for OLED device </p> <p class="inv_recrlist__info">Digest of Technical Papers - SID International Symposium, 2020, 51 (1), 1036-1039 </p> </li> <li> <p class="inv_recrlist__title">Analytical comparison of antibody-drug conjugates based on good manufacturing practice strategies </p> <p class="inv_recrlist__info">Analytical Sciences, 2020, 36 (7), 871-875 </p> </li> <li> <p class="inv_recrlist__title">Awake functional MRI detects neural circuit dysfunction in a mouse model of autism </p> <p class="inv_recrlist__info">Science Advances, 2020, 6 (6), eaav4520 </p> </li> <li> <p class="inv_recrlist__title">Coacervation in cationic polyelectrolyte solutions with anionic amino acid surfactants </p> <p class="inv_recrlist__info">Journal of Oleo Science, 2020, 69 (11), 1411-1416 </p> </li> <li> <p class="inv_recrlist__title">Isolation of four xylanases capable of hydrolyzing corn fiber xylan from Paenibacillus sp. 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