Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder

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Compound 5m (Lu AA21004) was the lead compound, displaying high affinity for recombinant human 5-HT( …"><meta name="keywords" content="pmid:21486038, doi:10.1021/jm101459g, Benny Bang-Andersen, Thomas Ruhland, Tine Bryan Stensbøl, Animals, Antidepressive Agents / chemical synthesis*, Antidepressive Agents / chemistry, Antidepressive Agents / pharmacology, Cell Line, Depressive Disorder, Major / drug therapy*, Drug Partial Agonism, Drug Stability, Hippocampus / drug effects, Hippocampus / metabolism, Humans, In Vitro Techniques, Microsomes, Liver / metabolism, Oocytes / drug effects, Oocytes / physiology, Piperazines / chemical synthesis*, Piperazines / chemistry, Piperazines / pharmacology, Radioligand Assay, Rats, Receptor, Serotonin, 5-HT1A / metabolism, Receptor, Serotonin, 5-HT2C / metabolism, Receptors, Serotonin / metabolism, Receptors, Serotonin, 5-HT1 / metabolism, Receptors, Serotonin, 5-HT3 / metabolism, Recombinant Proteins / agonists, Recombinant Proteins / antagonists & inhibitors, Selective Serotonin Reuptake Inhibitors / chemical synthesis, Selective Serotonin Reuptake Inhibitors / chemistry, Selective Serotonin Reuptake Inhibitors / pharmacology, Serotonin / metabolism, Serotonin 5-HT1 Receptor Agonists / chemical synthesis, Serotonin 5-HT1 Receptor Agonists / chemistry, Serotonin 5-HT1 Receptor Agonists / pharmacology, Serotonin 5-HT3 Receptor Antagonists / chemical synthesis, Serotonin 5-HT3 Receptor Antagonists / chemistry, Serotonin 5-HT3 Receptor Antagonists / pharmacology, Serotonin Plasma Membrane Transport Proteins / metabolism, Structure-Activity Relationship, Sulfides / chemical synthesis*, Sulfides / chemistry, Sulfides / pharmacology, Vortioxetine, Xenopus, PubMed Abstract, NIH, NLM, NCBI, National Institutes of Health, National Center for Biotechnology Information, National Library of Medicine, MEDLINE"><meta name="robots" content="index,nofollow,noarchive"><meta property="og:title" content="Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder - PubMed"><meta property="og:url" content="https://pubmed.ncbi.nlm.nih.gov/21486038/"><meta property="og:description" content="The synthesis and structure-activity relationship of a novel series of compounds with combined effects on 5-HT(3A) and 5-HT(1A) receptors and on the serotonin (5-HT) transporter (SERT) are described. Compound 5m (Lu AA21004) was the lead compound, displaying high affinity for recombinant human 5-HT( …"><meta property="og:image" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg"><meta property="og:image:secure_url" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg"><meta property="og:type" content="website"><meta property="og:site_name" content="PubMed"><meta name="twitter:domain" content="pubmed.ncbi.nlm.nih.gov"><meta name="twitter:card" content="summary_large_image"><meta name="twitter:title" content="Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder - PubMed"><meta name="twitter:url" content="https://pubmed.ncbi.nlm.nih.gov/21486038/"><meta name="twitter:description" content="The synthesis and structure-activity relationship of a novel series of compounds with combined effects on 5-HT(3A) and 5-HT(1A) receptors and on the serotonin (5-HT) transporter (SERT) are described. Compound 5m (Lu AA21004) was the lead compound, displaying high affinity for recombinant human 5-HT( …"><meta name="twitter:image" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg">  <link rel="search" type="application/opensearchdescription+xml" href="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/opensearch.xml" title="PubMed search">  <noscript> <link rel="stylesheet" type="text/css" href="https://cdn.ncbi.nlm.nih.gov/pubmed/14efe001-aebf-4097-9883-28c967333423/core/no-script.css"> </noscript> <meta name="citation_title" content="Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder"> <meta name="citation_authors" content="Bang-Andersen B;Ruhland T;Jørgensen M;Smith G;Frederiksen K;Jensen KG;Zhong H;Nielsen SM;Hogg S;Mørk A;Stensbøl TB;"> <meta name="citation_date" content="05/12/2011"> <meta name="citation_publisher" content="J Med Chem"> <meta name="citation_journal_title" content="Journal of medicinal chemistry"> <meta name="citation_pmid" content="21486038"> <meta name="citation_abstract_html_url" content="https://pubmed.ncbi.nlm.nih.gov/21486038/"> <meta name="citation_volume" content="54"> <meta name="citation_issue" content="9"> <meta name="citation_doi" content="10.1021/jm101459g"> <meta name="citation_issn" content="1520-4804"> <link rel="canonical" href="https://pubmed.ncbi.nlm.nih.gov/21486038/" /> </head> <body > <noscript> <div class="no-script-banner" id="no-script-banner"> <div class="warning-message"> <div class="warning-message-text"> This site needs JavaScript to work properly. 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id="email-citation-format" name="citation-format" class="action-panel-selector email-citation-format"> <option selected="selected" value="summary">Summary</option> <option value="summary-text">Summary (text)</option> <option value="abstract">Abstract</option> <option value="abstract-text">Abstract (text)</option> </select> </div> <div class="include-supplemental-container"> <input type="checkbox" aria-label="Include MeSH and other data" name="include-supplemental" id="email-include-supplemental" class="email-include-supplemental"> <label for="email-include-supplemental" class="email-include-supplemental-label">MeSH and other data</label> </div> <div class="form-field recaptcha "> <div class="g-recaptcha" id="id-recaptcha" data-sitekey="6LfsWHMdAAAAAClKbtOpjQ2pMjgsGxvv7NdZW9uI"></div> </div> <div id="captcha-error-message" class="usa-input-error-message captcha-validation-message" role="alert"></div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" 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class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-existing-collections-url="/list-existing-collections/" data-add-to-existing-collection-url="/add-to-existing-collection/" data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/" data-get-article-ids-by-search-url="/get-article-ids-by-search/" data-myncbi-max-collection-name-length="100" data-add-to-collection-max-amount="1000" data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/"> <input type="hidden" name="csrfmiddlewaretoken" value="drPqN2oNBV324z8AeXcUHEbp0LGt3i6bwxDPoDvHhsF4dmsnpYGTb8YmPAYUnS8w"> <div class="choice-group" role="radiogroup"> <ul class="radio-group-items"> <li> <input type="radio" id="collections-action-panel-new" class="collections-new" name="collections" value="new" data-ga-category="save_share" data-ga-action="collections" data-ga-label="collections_radio_new"> <label for="collections-action-panel-new">Create a new collection</label> </li> <li> <input type="radio" id="collections-action-panel-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="save_share" data-ga-action="collections" data-ga-label="collections_radio_existing"> <label for="collections-action-panel-existing">Add to an existing collection</label> </li> </ul> </div> <div class="controls-wrapper"> <div class="action-panel-control-wrap new-collections-controls"> <label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label> <input type="text" name="add-to-new-collection" id="collections-action-panel-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="save_share" data-ga-action="create_collection" data-ga-label="non_favorties_collection"> <div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div> </div> <div class="action-panel-control-wrap existing-collections-controls"> <label for="collections-action-panel-add-to-existing" class="action-panel-label"> Choose a collection: </label> <select id="collections-action-panel-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="save_share" data-ga-action="select_collection" data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"> </select> <div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br> <a href="#">Please try again</a> </div> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="save_share" data-ga-action="collections" data-ga-label="add"> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="collections" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="bibliography-action-panel" class="bibliography-action-panel action-panel in-progress-dots-panel" aria-hidden="true" data-bibliography-open-panel-enabled="false" data-bibliography-open-panel-url-hash="#open-bibliography-panel"> <div class="inner-wrap"> <h3 class="action-panel-heading"> Add to My Bibliography </h3> <form id="bibliography-action-panel-form" class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-add-to-bibliography-max-amount="100" data-add-to-bibliography-batch-size="10" data-bibliography-delegates-url="/list-bibliography-delegates/" data-add-to-bibliography-url="/add-to-bibliography/" data-get-article-ids-by-search-url="/get-article-ids-by-search/" data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/"> <input type="hidden" name="csrfmiddlewaretoken" value="drPqN2oNBV324z8AeXcUHEbp0LGt3i6bwxDPoDvHhsF4dmsnpYGTb8YmPAYUnS8w"> <div class="action-panel-control-wrap bibliographies-controls"> <div class="choice-group"> <ul class="bibliographies-action-add radio-group-items"> <li> <input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/> <label for="my-bibliography">My Bibliography</label> </li> </ul> </div> </div> <div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your delegates due to an error<br> <a href="#">Please try again</a> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to bibliography' panel" ref="linksrc=close_bibliography_panel" aria-controls="bibliography-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="mybib" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true" data-saved-search-open-panel-enabled="false" data-saved-search-open-panel-url-hash="#open-saved-search-panel"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your saved search </h2> <form id="saved-search-action-panel-form" class="saved-search-action-panel-form action-panel-content action-form" data-create-saved-search-url="/create-saved-search/" data-try-search-terms-url="/try-search-term/" data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/"> <input type="hidden" name="csrfmiddlewaretoken" value="drPqN2oNBV324z8AeXcUHEbp0LGt3i6bwxDPoDvHhsF4dmsnpYGTb8YmPAYUnS8w"> <div class="action-panel-control-wrap"> <label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk"> Name of saved search: </label> <input maxlength="200" type="text" name="saved-search-name" id="saved-search-name" class="saved-search-name" value="" required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="action-panel-control-wrap"> <label for="saved-search-term" class="action-panel-label required-field-asterisk"> Search terms: </label> <textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea> </div> <div class="test-search-term-wrap"> <a href="#" class="try-search-term">Test search terms</a> </div> <div class="choice-group action-panel-extra-margin-top"> <span class="action-panel-label" id="fieldset-label"> Would you like email updates of new search results? </span> <fieldset id="saved-search-alert" aria-describedby="fieldset-label"> <legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend> <ul class="radio-group-items"> <li> <input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked> <label for="saved-search-alert-yes" class="action-panel-label">Yes</label> </li> <li> <input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no"> <label for="saved-search-alert-no" class="action-panel-label">No</label> </li> </ul> </fieldset> </div> <div class="alert-schedule-wrap"> <div class="action-panel-control-wrap"> <label class="action-panel-label"> Email: </label> <span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span> </div> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="saved-search-frequency" class="action-panel-label"> Frequency: </label> <select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency"> <option value="monthly">Monthly</option> <option value="weekly">Weekly</option> <option value="daily">Daily</option> </select> </div> <div class="action-panel-control-wrap saved-search-monthly-additional"> <label for="saved-search-monthly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-monthly-on-day" class="no-border-panel-selector"> <option value="Sunday">The first Sunday</option> <option value="Monday">The first Monday</option> <option value="Tuesday">The first Tuesday</option> <option value="Wednesday">The first Wednesday</option> <option value="Thursday">The first Thursday</option> <option value="Friday">The first Friday</option> <option value="Saturday">The first Saturday</option> <option value="day">The first day</option> <option value="weekday">The first weekday</option> </select> </div> <div class="action-panel-control-wrap saved-search-weekly-additional"> <label for="saved-search-weekly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day"> <option value="Sunday">Sunday</option> <option value="Monday">Monday</option> <option value="Tuesday">Tuesday</option> <option value="Wednesday">Wednesday</option> <option value="Thursday">Thursday</option> <option value="Friday">Friday</option> <option value="Saturday">Saturday</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-report" class="action-panel-label"> Report format: </label> <select id="saved-search-report" class="no-border-panel-selector saved-search-report"> <option value="DocSum">Summary</option> <option value="DocSumText">Summary (text)</option> <option value="Abstract">Abstract</option> <option value="AbstractText">Abstract (text)</option> <option value="MEDLINE">PubMed</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-amount" class="action-panel-label"> Send at most: </label> <select id="saved-search-amount" class="no-border-panel-selector saved-search-amount"> <option value="1">1 item</option> <option value="5" selected>5 items</option> <option value="10">10 items</option> <option value="20">20 items</option> <option value="50">50 items</option> <option value="100">100 items</option> <option value="200">200 items</option> </select> </div> <div> <input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result"> <label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox"> Send even when there aren't any new results </label> </div> <div class="action-panel-control-wrap option-text-in-email-wrap"> <label for="saved-search-email-text" class="action-panel-label"> Optional text in email: </label> <textarea name="saved-search-email-text" id="saved-search-email-text" class="saved-search-email-text"></textarea> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Saving..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Save </button> <button class="action-panel-cancel" aria-label="Close 'Your saved search' panel" ref="linksrc=close_saved_search_panel" aria-controls="saved-search-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Create a file for external citation management software </h2> <form id="citation-manager-action-panel-form" class="action-panel-content action-form" action="/results-export-ids/" data-by-search-action="/results-export-search-data/" data-by-ids-action="/results-export-ids/" method="post" data-by-search-method="post" data-by-ids-method="post"> <input type="hidden" name="csrfmiddlewaretoken" value="drPqN2oNBV324z8AeXcUHEbp0LGt3i6bwxDPoDvHhsF4dmsnpYGTb8YmPAYUnS8w"> <input name="results-format" type="hidden" value="pubmed"/> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Sending..." data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="save"> Create file </button> <button class="action-panel-cancel" aria-label="Close 'Send citations to citation manager' panel" ref="linksrc=close_citation_manager_panel" aria-controls="citation-manager-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your RSS Feed </h2> <form id="rss-action-panel-form" class="rss-action-panel-form action-panel-content action-form" data-create-rss-feed-url="/create-rss-feed-url/" data-search-form-term-value=""> <input type="hidden" name="csrfmiddlewaretoken" value="drPqN2oNBV324z8AeXcUHEbp0LGt3i6bwxDPoDvHhsF4dmsnpYGTb8YmPAYUnS8w"> <div class="action-panel-control-wrap"> <label for="rss-name" class="action-panel-label required-field-asterisk"> Name of RSS Feed: </label> <input maxlength="200" placeholder="Name" type="text" name="rss-name" id="rss-name" class="rss-name" value='' required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="rss-limit-wrap"> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="rss-limit" class="action-panel-label"> Number of items displayed: </label> <select id="rss-limit" class="no-border-panel-selector rss-limit"> <option value="5">5</option> <option value="10">10</option> <option value="15" selected="selected">15</option> <option value="20">20</option> <option value="50">50</option> <option value="100">100</option> </select> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Creating..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Create RSS </button> <button class="action-panel-cancel" aria-label="Close 'Your RSS' panel" ref="linksrc=close_rss_panel" aria-controls="rss-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> <div class="action-panel-control-wrap rss-link-copy-wrap"> <label for="rss-link" class="usa-sr-only">RSS Link</label> <input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link"> <button type="button" disabled class="rss-link-copy-button disabled" data-ga-category="save_share" data-ga-action="rss" data-ga-label="copy"> Copy </button> </div> </form> </div> </div> </div> </div> <div class="article-page" id="article-page" data-article-pmid="21486038"> <aside class="page-sidebar"> <div class="inner-wrap"> <div class="full-text-links"> <div class="full-view"> <h3 class="title"> Full text links </h3> <div class="full-text-links-list"> <a class="link-item dialog-focus" href="https://doi.org/10.1021/jm101459g" target="_blank" rel="noopener" ref="linksrc=fulltextorjournal_fulltext&is_pmc=False&PrId=3001&itool=Abstract-def&log$=linkouticon&uid=21486038&db=pubmed&nlmid=9716531" title="See full text options at American Chemical Society" data-ga-category="full_text" data-ga-action="American Chemical Society" data-ga-label="21486038" ><img src="https://cdn.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--pubs.acs.org-images-pubmed-acspubs.jpg" alt="American Chemical Society full text link"><span class="text"> American Chemical Society </span></a> </div> </div> <div class="short-view"> <a href="#" class="full-text-links-button full-text-links-dialog-trigger"> Full text links </a> </div> </div> <div class="actions-buttons sidebar"><h3 class="title">Actions</h3><div class="inner-wrap"><button class="citation-button citation-dialog-trigger" aria-label="Open dialog with citation text in different styles" data-ga-category="save_share" data-ga-action="cite" data-ga-label="open" data-all-citations-url="/21486038/citations/" data-citation-style="nlm" data-pubmed-format-link="/21486038/export/"><span class="button-label">Cite</span></button><link type="text/css" href="ncbi-overlay-block/src/overlay-block.css"><div class="collections-button-container" data-article-id="21486038" data-article-db="pubmed"><button class="collections-button collections-dialog-trigger" aria-label="Save article in MyNCBI collections." data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_button" data-collections-open-dialog-enabled="false" data-collections-open-dialog-url="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F21486038%2F%23open-collections-dialog" data-in-collections="false"><span class="button-label">Collections</span></button><div class="overlay" role="dialog"><div id="collections-action-dialog" class="dialog collections-dialog" aria-hidden="true"><div class="title">Add to Collections</div><div class="collections-action-panel action-panel"><form id="collections-action-dialog-form" class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-existing-collections-url="/list-existing-collections/" data-add-to-existing-collection-url="/add-to-existing-collection/" data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/" data-myncbi-max-collection-name-length="100" data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/"><input type="hidden" name="csrfmiddlewaretoken" value="drPqN2oNBV324z8AeXcUHEbp0LGt3i6bwxDPoDvHhsF4dmsnpYGTb8YmPAYUnS8w"><div class="choice-group" role="radiogroup"><ul class="radio-group-items"><li><input type="radio" id="collections-action-dialog-new" class="collections-new" name="collections" value="new" data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_radio_new"><label for="collections-action-dialog-new">Create a new collection</label></li><li><input type="radio" id="collections-action-dialog-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_radio_existing"><label for="collections-action-dialog-existing">Add to an existing collection</label></li></ul></div><div class="controls-wrapper"><div class="action-panel-control-wrap new-collections-controls"><label for="collections-action-dialog-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label><input type="text" name="add-to-new-collection" id="collections-action-dialog-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="collections_button" data-ga-action="create_collection" data-ga-label="non_favorties_collection"><div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div></div><div class="action-panel-control-wrap existing-collections-controls"><label for="collections-action-dialog-add-to-existing" class="action-panel-label"> Choose a collection: </label><select id="collections-action-dialog-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="collections_button" data-ga-action="select_collection" data-ga-label="($('.collections-action-add-to-existing').val() === 'Favorites') ? 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Lundbeck A/S , 9 Ottiliavej, DK-2500 Copenhagen-Valby, Denmark. ban@lundbeck.com" href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Ruhland+T&cauthor_id=21486038" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Thomas Ruhland">Thomas Ruhland</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=J%C3%B8rgensen+M&cauthor_id=21486038" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Morten Jørgensen">Morten Jørgensen</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Smith+G&cauthor_id=21486038" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Garrick Smith">Garrick Smith</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Frederiksen+K&cauthor_id=21486038" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Kristen Frederiksen">Kristen Frederiksen</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Jensen+KG&cauthor_id=21486038" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Klaus Gjervig Jensen">Klaus Gjervig Jensen</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Zhong+H&cauthor_id=21486038" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Huailing Zhong">Huailing Zhong</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Nielsen+SM&cauthor_id=21486038" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Søren Møller Nielsen">Søren Møller Nielsen</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Hogg+S&cauthor_id=21486038" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Sandra Hogg">Sandra Hogg</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=M%C3%B8rk+A&cauthor_id=21486038" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Arne Mørk">Arne Mørk</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Stensb%C3%B8l+TB&cauthor_id=21486038" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Tine Bryan Stensbøl">Tine Bryan Stensbøl</a></span> </div> </div> </div> <div class="short-article-details"> Affiliations <button class="more-details" id="toggle-authors" data-alt-text="Collapse" aria-controls="expanded-authors" aria-expanded="false" data-pinger-ignore data-fetch-url="/21486038/long-authors/" data-id-prefix=""> <span class="title"> Expand </span> </button> </div> <div class="extended-article-details" id="expanded-authors" aria-hidden="true"> <div class="expanded-authors" id="full-view-expanded-authors"> <div class="affiliations"> <h3 class="title"> Affiliation </h3> <ul class="item-list"> <li data-affiliation-id="full-view-affiliation-1" id="full-view-affiliation-1" ><sup class="key">1</sup> Neuroscience Drug Discovery Denmark, H. Lundbeck A/S , 9 Ottiliavej, DK-2500 Copenhagen-Valby, Denmark. ban@lundbeck.com</li> </ul> </div> </div> </div> <ul class="identifiers" id="full-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">21486038</strong> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.1021/jm101459g&id_type=DOI" href="https://doi.org/10.1021/jm101459g" data-ga-category="full_text" data-ga-action="DOI" > 10.1021/jm101459g </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> <div class="short-view" id="short-view-heading"> <h1 class="heading-title"> Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder </h1> <div class="short-citation"> <span class="authors-list"> <span class="authors-list-item "><span class="full-name">Benny Bang-Andersen</span><span class="citation-separator"> et al.</span></span> </span> <span class="citation-journal"> J Med Chem<span class="citation-separator">.</span> </span> <span class="date"> <time class="citation-year" datetime="2011">2011</time><span class="citation-separator">.</span> </span> </div> <div class="more-article-details-section with-display-settings"> <button class="more-article-details" id="toggle-article-details" data-alt-text="Hide details" ref="linksrc=toggle_article_details" aria-controls="full-article-details" aria-expanded="false" data-fetch-url="/21486038/long-authors/" data-id-prefix=""> <span class="title">Show details</span> </button> <div class="display-options" data-format-key="format" data-default-format-value="abstract" data-current-format-value="abstract" role="region"> <button class="trigger usa-button" title="Change format" data-ga-category="display_options" data-ga-action="display_options_dialog"> <span class="button-label">Display options</span> </button> <div class="dropdown" hidden> <div class="title"> Display options </div> <div class="content"> <div class="format-container"> <span class="option-label"> Format </span> <select name="format" data-initial-value="abstract" aria-label="Display format" id="mobile-display-format"> <option value="abstract">Abstract</option> <option value="pubmed">PubMed</option> <option value="pmid">PMID</option> </select> </div> </div> </div> </div> </div> <div class="extended-article-details" id="full-article-details" aria-hidden="true"> <div class="article-citation"> <div class="article-source"> <div class="journal-actions dropdown-block"><button id="short-view-journal-trigger" class="journal-actions-trigger trigger" ref="linksrc=journal_actions_btn" title="Journal of medicinal chemistry" tabindex="0" aria-controls="short-view-journal" aria-expanded="false" aria-label="Toggle dropdown menu for journal 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Search in NLM Catalog </a></li><li><a class="add-to-search-link dropdown-block-link" ref ="linksrc=add_to_search_link" role="button" data-search-term='"J Med Chem"[jour]' data-ga-category="search" data-ga-action="add_to_search" data-ga-label='"J Med Chem"[jour]' href="#"> Add to Search </a></li></ul></div></div></div><span class="period">. </span><span class="cit">2011 May 12;54(9):3206-21.</span> </div> <span class="citation-doi"> doi: 10.1021/jm101459g. </span> <span class="secondary-date"> Epub 2011 Apr 12. </span> </div> <div class="expanded-authors" id="short-view-expanded-authors"> <div class="authors"> <h3 class="title"> Authors </h3> <div class="authors-list"> <span class="authors-list-item "><a class="full-name" href="/?term=Bang-Andersen+B&cauthor_id=21486038" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Benny Bang-Andersen">Benny Bang-Andersen</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Neuroscience Drug Discovery Denmark, H. Lundbeck A/S , 9 Ottiliavej, DK-2500 Copenhagen-Valby, Denmark. ban@lundbeck.com" href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Ruhland+T&cauthor_id=21486038" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Thomas Ruhland">Thomas Ruhland</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=J%C3%B8rgensen+M&cauthor_id=21486038" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Morten Jørgensen">Morten Jørgensen</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Smith+G&cauthor_id=21486038" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Garrick Smith">Garrick Smith</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Frederiksen+K&cauthor_id=21486038" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Kristen Frederiksen">Kristen Frederiksen</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Jensen+KG&cauthor_id=21486038" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Klaus Gjervig Jensen">Klaus Gjervig Jensen</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Zhong+H&cauthor_id=21486038" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Huailing Zhong">Huailing Zhong</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Nielsen+SM&cauthor_id=21486038" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Søren Møller Nielsen">Søren Møller Nielsen</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Hogg+S&cauthor_id=21486038" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Sandra Hogg">Sandra Hogg</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=M%C3%B8rk+A&cauthor_id=21486038" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Arne Mørk">Arne Mørk</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Stensb%C3%B8l+TB&cauthor_id=21486038" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Tine Bryan Stensbøl">Tine Bryan Stensbøl</a></span> </div> </div> <div class="affiliations"> <h3 class="title"> Affiliation </h3> <ul class="item-list"> <li data-affiliation-id="short-view-affiliation-1" id="short-view-affiliation-1" ><sup class="key">1</sup> Neuroscience Drug Discovery Denmark, H. Lundbeck A/S , 9 Ottiliavej, DK-2500 Copenhagen-Valby, Denmark. ban@lundbeck.com</li> </ul> </div> </div> <ul class="identifiers" id="short-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">21486038</strong> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.1021/jm101459g&id_type=DOI" href="https://doi.org/10.1021/jm101459g" data-ga-category="full_text" data-ga-action="DOI" > 10.1021/jm101459g </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> </div> </header> <div class="actions-buttons inline"><div class="inner-wrap"><button class="full-text-links-button full-text-links-dialog-trigger" title="Open dialog with full text links" ref="linksrc=full_text_links"> Full text links </button><button class="citation-button citation-dialog-trigger" aria-label="Open dialog with citation text in different styles" data-ga-category="save_share" data-ga-action="cite" data-ga-label="open" data-all-citations-url="/21486038/citations/" data-citation-style="nlm" data-pubmed-format-link="/21486038/export/"><span class="button-label">Cite</span></button><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button><div class="display-options" data-format-key="format" data-default-format-value="abstract" data-current-format-value="abstract" role="region"><button class="trigger usa-button" title="Change format" data-ga-category="display_options" data-ga-action="display_options_dialog"><span class="button-label">Display options</span></button><div class="dropdown" hidden><div class="title"> Display options </div><div class="content"><div class="format-container"><span class="option-label"> Format </span><select name="format" data-initial-value="abstract" aria-label="Display format" id="inline-actions-display-format"><option value="abstract">Abstract</option><option value="pubmed">PubMed</option><option value="pmid">PMID</option></select></div></div></div></div></div></div> <div class="abstract" id="abstract"> <h2 class="title"> Abstract </h2> <div class="abstract-content selected" id="eng-abstract"> <p> The synthesis and structure-activity relationship of a novel series of compounds with combined effects on 5-HT(3A) and 5-HT(1A) receptors and on the serotonin (5-HT) transporter (SERT) are described. Compound 5m (Lu AA21004) was the lead compound, displaying high affinity for recombinant human 5-HT(1A) (K(i) = 15 nM), 5-HT(1B) (K(i) = 33 nM), 5-HT(3A) (K(i) = 3.7 nM), 5-HT(7) (K(i) = 19 nM), and noradrenergic β(1) (K(i) = 46 nM) receptors, and SERT (K(i) = 1.6 nM). Compound 5m displayed antagonistic properties at 5-HT(3A) and 5-HT(7) receptors, partial agonist properties at 5-HT(1B) receptors, agonistic properties at 5-HT(1A) receptors, and potent inhibition of SERT. In conscious rats, 5m significantly increased extracellular 5-HT levels in the brain after acute and 3 days of treatment. Following the 3-day treatment (5 or 10 (mg/kg)/day) SERT occupancies were only 43% and 57%, respectively. These characteristics indicate that 5m is a novel multimodal serotonergic compound, and 5m is currently in clinical development for major depressive disorder. </p> </div> </div> <p class="disclaimer" id="disclaimer"> <a href="/disclaimer/" target="_blank" data-ga-category="literature_resources" data-ga-action="disclaimer_link" data-ga-label="under_abstract">PubMed Disclaimer</a> </p> <div class="similar-articles" id="similar"> <h2 class="title"> Similar articles </h2> <ul class="articles-list" id="similar-articles-list"> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"> <a class="docsum-title" href="/22612991/" ref="article_id=22612991&linksrc=similar_articles_link&ordinalpos=1" data-ga-category="similar_article" data-ga-action="22612991" data-ga-label=""> Lu AA21004, a novel multimodal antidepressant, produces regionally selective increases of multiple neurotransmitters--a rat microdialysis and electrophysiology study. </a> <div class="docsum-citation full-citation"> <span class="docsum-authors full-authors">Pehrson AL, Cremers T, Bétry C, van der Hart MG, Jørgensen L, Madsen M, Haddjeri N, Ebert B, Sanchez C.</span> <span class="docsum-authors short-authors">Pehrson AL, et al.</span> <span class="docsum-journal-citation full-journal-citation">Eur Neuropsychopharmacol. 2013 Feb;23(2):133-45. doi: 10.1016/j.euroneuro.2012.04.006. 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class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Piperazines%2Fchemical+synthesis%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Piperazines%2Fchemical+synthesis%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Piperazines/chemical synthesis"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Piperazines / chemical synthesis*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Piperazines" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Piperazines / chemical synthesis*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Piperazines/chemical synthesis"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Piperazines/chemical 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</button><div id="keyword-actions-mesh-terms-17" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Piperazines / pharmacology"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Piperazines%2Fpharmacology%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Piperazines%2Fpharmacology%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Piperazines/pharmacology"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Piperazines / pharmacology"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Piperazines" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Piperazines / pharmacology"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Piperazines/pharmacology"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Piperazines/pharmacology"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Radioligand Assay" tabindex="0" aria-controls="keyword-actions-mesh-terms-18" aria-expanded="false" data-pinger-ignore> Radioligand Assay </button><div id="keyword-actions-mesh-terms-18" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Radioligand Assay"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Radioligand+Assay%22%5BMeSH%5D&sort=date&sort_order=desc" 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data-search-term=""Antidepressive Agents"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Antidepressive Agents"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Piperazines" tabindex="0" aria-controls="keyword-actions-substances-1" aria-expanded="false" data-pinger-ignore> Piperazines </button><div id="keyword-actions-substances-1" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Piperazines"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Piperazines%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Piperazines%22%5Bnm%5D&sort=date&sort_order=desc" 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data-pinger-ignore> Receptor, Serotonin, 5-HT2C </button><div id="keyword-actions-substances-2" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Receptor, Serotonin, 5-HT2C"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Receptor%2C+Serotonin%2C+5-HT2C%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Receptor%2C+Serotonin%2C+5-HT2C%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Receptor, Serotonin, 5-HT2C"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Receptor, Serotonin, 5-HT2C"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Receptor%2C+Serotonin%2C+5-HT2C%22" data-ga-category="search_mesh" data-ga-action="substance_link" 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dropdown-block-link" href="/?term=%22Receptors%2C+Serotonin%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Receptors%2C+Serotonin%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Receptors, Serotonin"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Receptors, Serotonin"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Receptors%2C+Serotonin%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="Receptors, Serotonin"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Receptors, Serotonin"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Receptors, Serotonin"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Receptors, Serotonin, 5-HT1" tabindex="0" aria-controls="keyword-actions-substances-4" aria-expanded="false" data-pinger-ignore> Receptors, Serotonin, 5-HT1 </button><div id="keyword-actions-substances-4" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Receptors, Serotonin, 5-HT1"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Receptors%2C+Serotonin%2C+5-HT1%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Receptors%2C+Serotonin%2C+5-HT1%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Receptors, Serotonin, 5-HT1"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Receptors, Serotonin, 5-HT1"> Search in 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</a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Receptors, Serotonin, 5-HT3"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Receptors, Serotonin, 5-HT3"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Recombinant Proteins" tabindex="0" aria-controls="keyword-actions-substances-6" aria-expanded="false" data-pinger-ignore> Recombinant Proteins </button><div id="keyword-actions-substances-6" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Recombinant Proteins"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Recombinant+Proteins%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Recombinant+Proteins%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Recombinant Proteins"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Recombinant Proteins"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Recombinant+Proteins%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="Recombinant Proteins"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Recombinant Proteins"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Recombinant Proteins"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Serotonin 5-HT1 Receptor Agonists" tabindex="0" aria-controls="keyword-actions-substances-7" aria-expanded="false" data-pinger-ignore> Serotonin 5-HT1 Receptor Agonists </button><div id="keyword-actions-substances-7" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Serotonin 5-HT1 Receptor Agonists"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Serotonin+5-HT1+Receptor+Agonists%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Serotonin+5-HT1+Receptor+Agonists%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Serotonin 5-HT1 Receptor Agonists"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Serotonin 5-HT1 Receptor Agonists"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Serotonin+5-HT1+Receptor+Agonists%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="Serotonin 5-HT1 Receptor Agonists"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Serotonin 5-HT1 Receptor Agonists"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Serotonin 5-HT1 Receptor Agonists"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Serotonin 5-HT3 Receptor Antagonists" tabindex="0" aria-controls="keyword-actions-substances-8" aria-expanded="false" data-pinger-ignore> Serotonin 5-HT3 Receptor 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data-ga-action="substance_link" data-ga-label="Serotonin 5-HT3 Receptor Antagonists"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Serotonin 5-HT3 Receptor Antagonists"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Serotonin 5-HT3 Receptor Antagonists"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Serotonin Plasma Membrane Transport Proteins" tabindex="0" aria-controls="keyword-actions-substances-9" aria-expanded="false" data-pinger-ignore> Serotonin Plasma Membrane Transport Proteins </button><div id="keyword-actions-substances-9" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Serotonin Plasma Membrane Transport Proteins"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Serotonin+Plasma+Membrane+Transport+Proteins%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Serotonin+Plasma+Membrane+Transport+Proteins%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Serotonin Plasma Membrane Transport Proteins"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Serotonin Plasma Membrane Transport Proteins"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Serotonin+Plasma+Membrane+Transport+Proteins%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="Serotonin Plasma Membrane Transport Proteins"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Serotonin Plasma Membrane Transport Proteins"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Serotonin Plasma Membrane Transport Proteins"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Serotonin Uptake Inhibitors" tabindex="0" aria-controls="keyword-actions-substances-10" aria-expanded="false" data-pinger-ignore> Serotonin Uptake Inhibitors </button><div id="keyword-actions-substances-10" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Serotonin Uptake Inhibitors"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Serotonin+Uptake+Inhibitors%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Serotonin+Uptake+Inhibitors%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Serotonin Uptake Inhibitors"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Serotonin Uptake Inhibitors"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Serotonin+Uptake+Inhibitors%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="Serotonin Uptake Inhibitors"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Serotonin Uptake Inhibitors"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Serotonin Uptake Inhibitors"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Sulfides" tabindex="0" aria-controls="keyword-actions-substances-11" aria-expanded="false" data-pinger-ignore> Sulfides </button><div id="keyword-actions-substances-11" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Sulfides"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Sulfides%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Sulfides%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Sulfides"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Sulfides"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Sulfides%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="Sulfides"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Sulfides"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Sulfides"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword serotonin 7 receptor" tabindex="0" aria-controls="keyword-actions-substances-12" aria-expanded="false" data-pinger-ignore> serotonin 7 receptor </button><div id="keyword-actions-substances-12" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword serotonin 7 receptor"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22serotonin+7+receptor%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22serotonin+7+receptor%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="serotonin 7 receptor"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="serotonin 7 receptor"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22serotonin+7+receptor%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="serotonin 7 receptor"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""serotonin 7 receptor"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""serotonin 7 receptor"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Receptor, Serotonin, 5-HT1A" tabindex="0" aria-controls="keyword-actions-substances-13" aria-expanded="false" data-pinger-ignore> Receptor, Serotonin, 5-HT1A </button><div id="keyword-actions-substances-13" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Receptor, Serotonin, 5-HT1A"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Receptor%2C+Serotonin%2C+5-HT1A%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Receptor%2C+Serotonin%2C+5-HT1A%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Receptor, Serotonin, 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aria-expanded="false" data-pinger-ignore> Serotonin </button><div id="keyword-actions-substances-14" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Serotonin"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Serotonin%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Serotonin%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Serotonin"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Serotonin"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Serotonin%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="Serotonin"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" 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Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder - PubMed