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metronidazole</title> <meta name="description" content="Search results for: drug release metronidazole"> <meta name="keywords" content="drug release metronidazole"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="drug release metronidazole"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 2979</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: drug release metronidazole</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2979</span> Polymer Composites Of MOF-5 For Efficient and Sustained Delivery of Cephalexin and Metronidazole</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Anoff%20Anim">Anoff Anim</a>, <a href="https://publications.waset.org/abstracts/search?q=Lila%20Mahmoud"> Lila Mahmoud</a>, <a href="https://publications.waset.org/abstracts/search?q=Maria%20Katsikogianni"> Maria Katsikogianni</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanjit%20Nayak"> Sanjit Nayak</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Sustained and controlled delivery of antimicrobial drugs have been largely studied recently using metal organic frameworks (MOFs)and different polymers. However, much attention has not been given to combining both MOFs and biodegradable polymers, which would be a good strategy in providing a sustained gradual release of the drugs. Herein, we report a comparative study of the sustained and controlled release of widely used antibacterial drugs, cephalexin and metronidazole, from zinc-based MOF-5 incorporated in biodegradable polycaprolactone (PCL) and poly-lactic glycolic acid (PLGA) membranes. Cephalexin and metronidazole were separately incorporated in MOF-5 post-synthetically, followed by their integration into biodegradable PLGA and PCL membranes. The pristine MOF-5 and the loaded MOFs were thoroughly characterized by FT-IR, SEM, TGA and PXRD. Drug release studies were carried out to assess the release rate of the drugs in PBS and distilled water for up to 48 hours using UV-Vis Spectroscopy. Four bacterial strains from both the Gram-positive and Gram-negative types, Staphylococus aureus, Staphylococuss epidermidis, Escherichia coli, Acinetobacter baumanii, were tested against the pristine MOF, pure drugs, loaded MOFs and the drug-loaded MOF-polymer composites. Metronidazole-loaded MOF-5 composite of PLGA (PLGA-Met@MOF-5) was found to show highest efficiency to inhibit the growth of S. epidermidis compared to the other bacteria strains while maintaining a sustained minimum inhibitory concentration (MIC). This study demonstrates that the combination of biodegradable MOF-polymer composites can provide an efficient platform for sustained and controlled release of antimicrobial drugs and can be a potential strategy to integrate them in biomedical devices. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antimicrobial%20resistance" title="antimicrobial resistance">antimicrobial resistance</a>, <a href="https://publications.waset.org/abstracts/search?q=biodegradable%20polymers" title=" biodegradable polymers"> biodegradable polymers</a>, <a href="https://publications.waset.org/abstracts/search?q=cephalexin" title=" cephalexin"> cephalexin</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20release%20metronidazole" title=" drug release metronidazole"> drug release metronidazole</a>, <a href="https://publications.waset.org/abstracts/search?q=MOF-5" title=" MOF-5"> MOF-5</a>, <a href="https://publications.waset.org/abstracts/search?q=PCL" title=" PCL"> PCL</a>, <a href="https://publications.waset.org/abstracts/search?q=PLGA" title=" PLGA"> PLGA</a> </p> <a href="https://publications.waset.org/abstracts/170701/polymer-composites-of-mof-5-for-efficient-and-sustained-delivery-of-cephalexin-and-metronidazole" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/170701.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">133</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2978</span> Biodegradable Polymer Composites of MOF-5 for Efficient and Sustained Delivery of Cephalexin and Metronidazole</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Anoff%20Anim">Anoff Anim</a>, <a href="https://publications.waset.org/abstracts/search?q=Lila%20A.%20M.%20Mahmoud"> Lila A. M. Mahmoud</a>, <a href="https://publications.waset.org/abstracts/search?q=Maria%20Katsikogianni"> Maria Katsikogianni</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanjit%20Nayak"> Sanjit Nayak</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Sustained and controlled delivery of antimicrobial drugs have been largely studied recently using metal organic frameworks (MOFs)and different polymers. However, much attention has not been given to combining both MOFs and biodegradable polymers, which would be a good strategy in providing a sustained gradual release of the drugs. Herein, we report a comparative study of the sustained and controlled release of widely used antibacterial drugs, cephalexin and metronidazole, from zinc-based MOF-5 incorporated in biodegradable polycaprolactone (PCL) and poly-lactic glycolic acid (PLGA) membranes. Cephalexin and metronidazole were separately incorporated in MOF-5 post-synthetically, followed by their integration into biodegradable PLGA and PCL membranes. The pristine MOF-5 and the loaded MOFs were thoroughly characterized by FT-IR, SEM, TGA and PXRD. Drug release studies were carried out to assess the release rate of the drugs in PBS and distilled water for up to 48 hours using UV-Vis Spectroscopy. Four bacterial strains from both the Gram-positive and Gram-negative types, Staphylococus aureus, Staphylococuss epidermidis, Escherichia coli, Acinetobacter baumanii, were tested against the pristine MOF, pure drugs, loaded MOFs and the drug-loaded MOF-polymer composites. Metronidazole-loaded MOF-5 composite of PLGA (PLGA-Met@MOF-5) was found to show highest efficiency to inhibit the growth of S. epidermidis compared to the other bacteria strains while maintaining a sustained minimum inhibitory concentration (MIC). This study demonstrates that the combination of biodegradable MOF-polymer composites can provide an efficient platform for sustained and controlled release of antimicrobial drugs and can be a potential strategy to integrate them in biomedical devices. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antimicrobial%20resistance" title="antimicrobial resistance">antimicrobial resistance</a>, <a href="https://publications.waset.org/abstracts/search?q=biodegradable%20polymers" title=" biodegradable polymers"> biodegradable polymers</a>, <a href="https://publications.waset.org/abstracts/search?q=cephalexin" title=" cephalexin"> cephalexin</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20release%20metronidazole" title=" drug release metronidazole"> drug release metronidazole</a>, <a href="https://publications.waset.org/abstracts/search?q=MOF-5" title=" MOF-5"> MOF-5</a>, <a href="https://publications.waset.org/abstracts/search?q=PCL" title=" PCL"> PCL</a>, <a href="https://publications.waset.org/abstracts/search?q=PLGA" title=" PLGA"> PLGA</a> </p> <a href="https://publications.waset.org/abstracts/170686/biodegradable-polymer-composites-of-mof-5-for-efficient-and-sustained-delivery-of-cephalexin-and-metronidazole" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/170686.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">139</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2977</span> Reducing Antimicrobial Resistance Using Biodegradable Polymer Composites of Mof-5 for Efficient and Sustained Delivery of Cephalexin and Metronidazole</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Anoff%20Anim">Anoff Anim</a>, <a href="https://publications.waset.org/abstracts/search?q=Lila%20Mahmound"> Lila Mahmound</a>, <a href="https://publications.waset.org/abstracts/search?q=Maria%20Katsikogianni"> Maria Katsikogianni</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanjit%20Nayak"> Sanjit Nayak</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Sustained and controlled delivery of antimicrobial drugs have been largely studied recently using metal organic frameworks (MOFs)and different polymers. However, much attention has not been given to combining both MOFs and biodegradable polymers which would be a good strategy in providing a sustained gradual release of the drugs. Herein, we report a comparative study of the sustained and controlled release of widely used antibacterial drugs, cephalexin and metronidazole, from zinc-based MOF-5 incorporated in biodegradable polycaprolactone (PCL) and poly-lactic glycolic acid (PLGA) membranes. Cephalexin and metronidazole were separately incorporated in MOF-5 post-synthetically, followed by their integration into biodegradable PLGA and PCL membranes. The pristine MOF-5 and the loaded MOFs were thoroughly characterized by FT-IR, SEM, TGA and PXRD. Drug release studies were carried out to assess the release rate of the drugs in PBS and distilled water for up to 48 hours using UV-Vis Spectroscopy. Four bacterial strains from both the Gram-positive and Gram-negative types, Staphylococus aureus, Staphylococuss epidermidis, Escherichia coli, Acinetobacter baumanii, were tested against the pristine MOF, pure drugs, loaded MOFs and the drug-loaded MOF-polymer composites. Metronidazole-loaded MOF-5 composite of PLGA (PLGA-Met@MOF-5) was found to show highest efficiency to inhibit the growth of S. epidermidis compared to the other bacteria strains while maintaining a sustained minimum inhibitory concentration (MIC). This study demonstrates that the combination of biodegradable MOF-polymer composites can provide an efficient platform for sustained and controlled release of antimicrobial drugs, and can be a potential strategy to integrate them in biomedical devices. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antimicrobial%20resistance" title="antimicrobial resistance">antimicrobial resistance</a>, <a href="https://publications.waset.org/abstracts/search?q=biodegradable%20polymers" title=" biodegradable polymers"> biodegradable polymers</a>, <a href="https://publications.waset.org/abstracts/search?q=cephalexin" title=" cephalexin"> cephalexin</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20release%20metronidazole" title=" drug release metronidazole"> drug release metronidazole</a>, <a href="https://publications.waset.org/abstracts/search?q=MOF-5" title=" MOF-5"> MOF-5</a>, <a href="https://publications.waset.org/abstracts/search?q=PCL" title=" PCL"> PCL</a>, <a href="https://publications.waset.org/abstracts/search?q=PLGA" title=" PLGA"> PLGA</a> </p> <a href="https://publications.waset.org/abstracts/170695/reducing-antimicrobial-resistance-using-biodegradable-polymer-composites-of-mof-5-for-efficient-and-sustained-delivery-of-cephalexin-and-metronidazole" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/170695.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">85</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2976</span> Effect of Swelling Pressure on Drug Release from Polyelectrolyte Micro-Hydrogel Particles</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mina%20Boroujerdi">Mina Boroujerdi</a>, <a href="https://publications.waset.org/abstracts/search?q=Javad%20Tavakoli"> Javad Tavakoli</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Hydrogels are extensively studied as matrices for the controlled release of drugs. To evaluate the mobility of embedded molecules, these drug delivery systems are usually characterized by release studies. In this contribution, an electronic device for swelling pressure measurement during drug release from hydrogel network was developed. Also, poly acrylic acid micro particles were prepared for prolonged and sustained controlled acetaminophen release. Effect of swelling pressure on drug release from micro particles studied under different environment pH in order to predict release profile in gastro-intestine medium. Swelling ratio and swelling pressure were measured in different pH. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=swelling%20pressure" title="swelling pressure">swelling pressure</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20delivery" title=" drug delivery"> drug delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrogel" title=" hydrogel"> hydrogel</a>, <a href="https://publications.waset.org/abstracts/search?q=polyelectrolyte" title=" polyelectrolyte"> polyelectrolyte</a> </p> <a href="https://publications.waset.org/abstracts/54759/effect-of-swelling-pressure-on-drug-release-from-polyelectrolyte-micro-hydrogel-particles" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/54759.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">298</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2975</span> Antimicrobial Efficacy of 0.75% Metronidazole and 2% Chlorhexidine Gel Applied in Implant Screw Hole: A Clinical Trial</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mostafa%20Solati">Mostafa Solati</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objectives: Considering the gap of information regarding the optimal antimicrobial efficacy of metronidazole for application in the implant screw hole, this study aimed to compare the antimicrobial efficacy of 0.75% metronidazole and 2% chlorhexidine (CHX) gel applied in the implant screw hole. Materials and Methods: This randomized controlled clinical trial evaluated 60 implants (20 patients, each requiring three implants) in three groups (n=20). In group 1, 0.75% metronidazole gel was applied to the implant screw hole. In group 2, 2% CHX gel was applied, and in group 3, no material was used. Microbial samples were collected from the screw holes after three months, and the microbial colonies were counted. Data were analyzed using ANOVA. Results: The number of bacteria in the control group was significantly higher than that in 0.75% metronidazole gel and 2% CHX groups (P<0.05). The CHX group caused the maximum reduction in colony count with no significant difference from the metronidazole group (P>0.05). Conclusion: The application of 0.75% metronidazole gel and 2% CHX can effectively decrease the colony count in the implant screw hole and can probably play a role in the preservation of peri-implant tissue health. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=dental%20implant" title="dental implant">dental implant</a>, <a href="https://publications.waset.org/abstracts/search?q=metronidazole" title=" metronidazole"> metronidazole</a>, <a href="https://publications.waset.org/abstracts/search?q=CHX" title=" CHX"> CHX</a>, <a href="https://publications.waset.org/abstracts/search?q=screw%20hole" title=" screw hole"> screw hole</a> </p> <a href="https://publications.waset.org/abstracts/160657/antimicrobial-efficacy-of-075-metronidazole-and-2-chlorhexidine-gel-applied-in-implant-screw-hole-a-clinical-trial" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/160657.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">70</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2974</span> Formulation of Extended-Release Ranolazine Tablet and Investigation Its Stability in the Accelerated Stability Condition at 40⁰C and 75% Humidity</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Farzad%20Khajavi">Farzad Khajavi</a>, <a href="https://publications.waset.org/abstracts/search?q=Farzaneh%20Jalilfar"> Farzaneh Jalilfar</a>, <a href="https://publications.waset.org/abstracts/search?q=Faranak%20Jafari"> Faranak Jafari</a>, <a href="https://publications.waset.org/abstracts/search?q=Leila%20Shokrani"> Leila Shokrani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Formulation of Ranolazine in the form of extended-release tablet in 500 mg dosage form was performed using Eudragit L100-55 as a retarding agent. Drug-release profiles were investigated in comparison with the reference Ranexa extended-release 500 mg tablet. F₂ and f₁ were calculated as 64.16 and 8.53, respectively. According to Peppas equation, the release of drug is controlled by diffusion (n=0.5). The tablets were put into accelerated stability conditions (40 °C, 75% humidity) for 3 and 6 months. The dissolution release profiles and other physical and chemical characteristics of the tablets confirmed the robustness and stability of formulation in this condition. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=drug%20release" title="drug release">drug release</a>, <a href="https://publications.waset.org/abstracts/search?q=extended-release%20tablet" title=" extended-release tablet"> extended-release tablet</a>, <a href="https://publications.waset.org/abstracts/search?q=ranolazine" title=" ranolazine"> ranolazine</a>, <a href="https://publications.waset.org/abstracts/search?q=stability" title=" stability"> stability</a> </p> <a href="https://publications.waset.org/abstracts/127040/formulation-of-extended-release-ranolazine-tablet-and-investigation-its-stability-in-the-accelerated-stability-condition-at-40c-and-75-humidity" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/127040.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">155</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2973</span> Formulation and in vitro Evaluation of Sustained Release Matrix Tablets of Levetiracetam for Better Epileptic Treatment</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nagasamy%20Venkatesh%20Dhandapani">Nagasamy Venkatesh Dhandapani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The objective of the present study was to develop sustained release oral matrix tablets of anti epileptic drug levetiracetam. The sustained release matrix tablets of levetiracetam were prepared using hydrophilic matrix hydroxypropyl methylcellulose (HPMC) as a release retarding polymer by wet granulation method. Prior to compression, FTIR studies were performed to understand the compatibility between the drug and excipients. The study revealed that there was no chemical interaction between drug and excipients used in the study. The tablets were characterized by physical and chemical parameters and results were found in acceptable limits.<em> In vitro</em> release study was carried out for the tablets using 0.1 N HCl for 2 hours and in phosphate buffer pH 7.4 for remaining time up to 12 hours. The effect of polymer concentration was studied. Different dissolution models were applied to drug release data in order to evaluate release mechanisms and kinetics. The drug release data fit well to zero order kinetics. Drug release mechanism was found as a complex mixture of diffusion, swelling and erosion. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=levetiracetam" title="levetiracetam">levetiracetam</a>, <a href="https://publications.waset.org/abstracts/search?q=sustained-release" title=" sustained-release"> sustained-release</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrophilic%20matrix%20tablet" title=" hydrophilic matrix tablet"> hydrophilic matrix tablet</a>, <a href="https://publications.waset.org/abstracts/search?q=HPMC%20grade%20K%20100%20MCR" title=" HPMC grade K 100 MCR"> HPMC grade K 100 MCR</a>, <a href="https://publications.waset.org/abstracts/search?q=wet%20granulation" title=" wet granulation"> wet granulation</a>, <a href="https://publications.waset.org/abstracts/search?q=zero%20order%20release%20kinetics" title=" zero order release kinetics"> zero order release kinetics</a> </p> <a href="https://publications.waset.org/abstracts/58363/formulation-and-in-vitro-evaluation-of-sustained-release-matrix-tablets-of-levetiracetam-for-better-epileptic-treatment" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/58363.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">316</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2972</span> Development of pH Responsive Nanoparticles for Colon Targeted Drug Delivery System</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=V.%20Balamuralidhara">V. Balamuralidhara</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The aim of the present work was to develop Paclitaxel loaded polyacrylamide grafted guar gum nanoparticles as pH responsive nanoparticle systems for targeting colon. The pH sensitive nanoparticles were prepared by modified ionotropic gelation technique. The prepared nanoparticles showed mean diameters in the range of 264±0.676 nm to 726±0.671nm, and a negative net charge 10.8 mV to 35.4mV. Fourier Transformed Infrared Spectroscopy (FT-IR) and Differential Scanning Calorimetry (DSC) studies suggested that there was no chemical interaction between drug and polymers. The encapsulation efficiency of the drug was found to be 40.92% to 48.14%. The suitability of the polyacrylamide grafted guar gum ERN’s for the release of Paclitaxel was studied by in vitro release at pH 1.2 and 7.4. It was observed that, there was no significant amount of drug release at gastric pH and 97.63% of drug release at pH 7.4 was obtained for optimized formulation F3 at the end of 12 hrs. In vivo drug targeting performance for the prepared optimized formulation (F3) and pure drug Paclitaxel was evaluated by HPLC. It was observed that the polyacrylamide grafted guar gum can be used to prepare nanoparticles for targeting the drug to the colon. The release performance was greatly affected by the materials used in ERN’s preparation, which allows maximum release at colon’s pH. It may be concluded that polyacrylamide grafted guar gum nanoparticles loaded with paclitaxel have desirable release responsive to specific pH. Hence it is a unique approach for colonic delivery of drug having appropriate site specificity and feasibility and controlled release of drug. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=colon%20targeting" title="colon targeting">colon targeting</a>, <a href="https://publications.waset.org/abstracts/search?q=polyacrylamide%20grafted%20guar%20gum%20nanoparticles" title=" polyacrylamide grafted guar gum nanoparticles"> polyacrylamide grafted guar gum nanoparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=paclitaxel" title=" paclitaxel"> paclitaxel</a>, <a href="https://publications.waset.org/abstracts/search?q=nanoparticles" title=" nanoparticles"> nanoparticles</a> </p> <a href="https://publications.waset.org/abstracts/8472/development-of-ph-responsive-nanoparticles-for-colon-targeted-drug-delivery-system" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/8472.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">353</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2971</span> Effect of Ethyl Cellulose and Hydroxy Propyl Methyl Cellulose Polymer on the Release Profile of Diltiazem Hydrochloride Sustained Release Pellets </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Shahana%20Sharmin">Shahana Sharmin</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In the present study, the effect of cellulose polymers Ethyl Cellulose and Hydroxy Propyl Methyl Cellulose was evaluated on the release profile of drug from sustained release pellet. Diltiazem Hydrochloride, an antihypertensive, cardio-protective agent and slow channel blocker were used as a model drug to evaluate its release characteristics from different pellets formulations. Diltiazem Hydrochloride sustained release pellets were prepared by drug loading (drug binder suspension) on neutral pellets followed by different percentages of spraying, i.e. 2%,4%, 6%, 8% and 10% coating suspension using ethyl cellulose and hydroxy-propyl methyl cellulose polymer in a fixed 85:15 ratios respectively. The in vitro dissolution studies of Diltiazem Hydrochloride from these sustained release pellets were carried out in pH 7.2 phosphate buffer for 1, 2, 3, 4, 5, 6, 7, and 8 hrs using USP-I method. Statistically, significant differences were found among the drug release profile from different formulations. Polymer content with the highest concentration of Ethyl cellulose on the pellets shows the highest release retarding rate of the drug. The retarding capacity decreases with the decreased concentration of ethyl cellulose. The release mechanism was explored and explained with zero order, first order, Higuchi and Korsmeyer’s equations. Finally, the study showed that the profile and kinetics of drug release were functions of polymer type, polymer concentration & the physico-chemical properties of the drug. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diltiazem%20hydrochloride" title="diltiazem hydrochloride">diltiazem hydrochloride</a>, <a href="https://publications.waset.org/abstracts/search?q=ethyl%20cellulose" title=" ethyl cellulose"> ethyl cellulose</a>, <a href="https://publications.waset.org/abstracts/search?q=hydroxy%20propyl%20methyl%20cellulose" title=" hydroxy propyl methyl cellulose"> hydroxy propyl methyl cellulose</a>, <a href="https://publications.waset.org/abstracts/search?q=release%20kinetics" title=" release kinetics"> release kinetics</a>, <a href="https://publications.waset.org/abstracts/search?q=sustained%20release%20pellets" title=" sustained release pellets"> sustained release pellets</a> </p> <a href="https://publications.waset.org/abstracts/21180/effect-of-ethyl-cellulose-and-hydroxy-propyl-methyl-cellulose-polymer-on-the-release-profile-of-diltiazem-hydrochloride-sustained-release-pellets" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/21180.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">414</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2970</span> Formulation of Extended-Release Gliclazide Tablet Using a Mathematical Model for Estimation of Hypromellose</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Farzad%20Khajavi">Farzad Khajavi</a>, <a href="https://publications.waset.org/abstracts/search?q=Farzaneh%20Jalilfar"> Farzaneh Jalilfar</a>, <a href="https://publications.waset.org/abstracts/search?q=Faranak%20Jafari"> Faranak Jafari</a>, <a href="https://publications.waset.org/abstracts/search?q=Leila%20Shokrani"> Leila Shokrani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Formulation of gliclazide in the form of extended-release tablet in 30 and 60 mg dosage forms was performed using hypromellose (HPMC K4M) as a retarding agent. Drug-release profiles were investigated in comparison with references Diamicron MR 30 and 60 mg tablets. The effect of size of powder particles, the amount of hypromellose in formulation, hardness of tablets, and also the effect of halving the tablets were investigated on drug release profile. A mathematical model which describes hypromellose behavior in initial times of drug release was proposed for the estimation of hypromellose content in modified-release gliclazide 60 mg tablet. This model is based on erosion of hypromellose in dissolution media. The model is applicable to describe release profiles of insoluble drugs. Therefore, by using dissolved amount of drug in initial times of dissolution and the model, the amount of hypromellose in formulation can be predictable. The model was used to predict the HPMC K4M content in modified-release gliclazide 30 mg and extended-release quetiapine 200 mg tablets. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Gliclazide" title="Gliclazide">Gliclazide</a>, <a href="https://publications.waset.org/abstracts/search?q=hypromellose" title=" hypromellose"> hypromellose</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20release" title=" drug release"> drug release</a>, <a href="https://publications.waset.org/abstracts/search?q=modified-release%20tablet" title=" modified-release tablet"> modified-release tablet</a>, <a href="https://publications.waset.org/abstracts/search?q=mathematical%20model" title=" mathematical model"> mathematical model</a> </p> <a href="https://publications.waset.org/abstracts/75442/formulation-of-extended-release-gliclazide-tablet-using-a-mathematical-model-for-estimation-of-hypromellose" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/75442.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">222</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2969</span> Release of Calcein from Liposomes Using Low and High Frequency Ultrasound</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ghaleb%20A.%20Husseini">Ghaleb A. Husseini</a>, <a href="https://publications.waset.org/abstracts/search?q=Salma%20E.%20Ahmed"> Salma E. Ahmed</a>, <a href="https://publications.waset.org/abstracts/search?q=Hesham%20G.%20Moussa"> Hesham G. Moussa</a>, <a href="https://publications.waset.org/abstracts/search?q=Ana%20M.%20Martins"> Ana M. Martins</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammad%20Al-Sayah"> Mohammad Al-Sayah</a>, <a href="https://publications.waset.org/abstracts/search?q=Nasser%20Qaddoumi"> Nasser Qaddoumi </a> </p> <p class="card-text"><strong>Abstract:</strong></p> This abstract aims to investigate the use of targeted liposomes as anticancer drug carriers in vitro in combination with ultrasound applied as drug trigger; in order to reduce the side effects caused by traditional chemotherapy. Pegylated liposomes were used to encapsulate calcein and then release this model drug when 20-kHz, 40-kHz, 1-MHz and 3-MHz ultrasound were applied at different acoustic power densities. Fluorescence techniques were then used to measure the percent drug release of calcein from these targeted liposomes. Results showed that as the power density increases, at the four frequencies studied, the release of calcein also increased. Based on these results, we believe that ultrasound can be used to increase the rate and amount of chemotherapeutics release from liposomes. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=liposomes" title="liposomes">liposomes</a>, <a href="https://publications.waset.org/abstracts/search?q=calcein%20release" title=" calcein release"> calcein release</a>, <a href="https://publications.waset.org/abstracts/search?q=high%20frequency%20ultrasound" title=" high frequency ultrasound"> high frequency ultrasound</a>, <a href="https://publications.waset.org/abstracts/search?q=low%20frequency%20ultrasound" title=" low frequency ultrasound"> low frequency ultrasound</a>, <a href="https://publications.waset.org/abstracts/search?q=fluorescence%20techniques" title=" fluorescence techniques"> fluorescence techniques</a> </p> <a href="https://publications.waset.org/abstracts/24679/release-of-calcein-from-liposomes-using-low-and-high-frequency-ultrasound" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/24679.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">424</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2968</span> Determination of the Effect of Kaolin on the Antimicrobial Activity of Metronidazole-Kaolin Interaction</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Omaimah%20Algohary">Omaimah Algohary</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Kaolin is one of the principle intestinal adsorbents, has traditionally been used internally in the treatment of various enteric disorders, colitis, enteritis, dysentery, and diarrhea associated with food and alkaloidal poisoning and in traveler’s diarrhea. It binds to and traps bacteria and its toxins and gases in the gut. It also binds to water in the gut, which helps to make the stools firmer, hence giving symptomatic relief. Metronidazole is a synthetic antibacterial agent that is used primarily in the treatment of various anaerobic infections such as intra-abdominal infections, antiprotozoal, and as amebicidal. The need for safe, therapeutically effective antidiarrheal combination continuously lead to effective treatment. Metronidazol used for treatment of anaerobic bacteria and kaolin , when administered simultaneously, Metronidazole–Kaolin interactions have been reported by FDA but not studied. This project is the first to study the effect of Metronidazole–Kaolin interactions on the antimicrobial activity of metronidazole. Agar diffusion method performed to test the antimicrobial activity of metronidazole–kaolin antidiarrheal combination from aqueous solutions at an in-vivo simulated pHs conditions that obtained at 37+0.5 °C on Helicobacter pylori as anaerobic bacteria and E.coli as aerobic bacteria and used as a control for the technique. The antimicrobial activity of metronidazole combination as 1:1 and 1:2 with kaolin was abolished in acidic media as no zones of inhibition shown compared to only metronidazole that used as a control. In alkaline media metronidazole combination as 1:1 and 1:2 with kaolin showed diminutive activity compared to the control. These results proved that the kaolin adsorb metronidazole and abolish its antimicrobial activity and such combination should be avoided. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=kaolin" title="kaolin">kaolin</a>, <a href="https://publications.waset.org/abstracts/search?q=metronidazole" title=" metronidazole"> metronidazole</a>, <a href="https://publications.waset.org/abstracts/search?q=interaction" title=" interaction"> interaction</a>, <a href="https://publications.waset.org/abstracts/search?q=Helicobacter%20pylori.%20E.%20coli" title=" Helicobacter pylori. E. coli"> Helicobacter pylori. E. coli</a>, <a href="https://publications.waset.org/abstracts/search?q=antimicrobial%20activity" title=" antimicrobial activity"> antimicrobial activity</a> </p> <a href="https://publications.waset.org/abstracts/14957/determination-of-the-effect-of-kaolin-on-the-antimicrobial-activity-of-metronidazole-kaolin-interaction" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/14957.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">389</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2967</span> Spray-Dried, Biodegradable, Drug-Loaded Microspheres for Use in the Treatment of Lung Diseases</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mazen%20AlGharsan">Mazen AlGharsan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objective: The Carbopol Microsphere of Linezolid, a drug used to treat lung disease (pulmonary disease), was prepared using Buchi B-90 nano spray-drier. Methods: Production yield, drug content, external morphology, particle size, and in vitro release pattern were performed. Results: The work was 79.35%, and the drug content was 66.84%. The surface of the particles was shriveled in shape, with particle size distribution with a mean diameter of 9.6 µm; the drug was released in a biphasic manner with an initial release of 25.2 ± 5.7% at 60 minutes. It later prolonged the release by 95.5 ± 2.5% up to 12 hours. Differential scanning calorimetry (DSC) revealed no change in the melting point of the formulation. Fourier-transform infrared (FT-IR) studies showed no polymer-drug interaction in the prepared nanoparticles. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=nanotechnology" title="nanotechnology">nanotechnology</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20delivery" title=" drug delivery"> drug delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=Linezolid" title=" Linezolid"> Linezolid</a>, <a href="https://publications.waset.org/abstracts/search?q=lung%20disease" title=" lung disease"> lung disease</a> </p> <a href="https://publications.waset.org/abstracts/193025/spray-dried-biodegradable-drug-loaded-microspheres-for-use-in-the-treatment-of-lung-diseases" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/193025.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">13</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2966</span> Numerical Investigation of Thermally Triggered Release Kinetics of Double Emulsion for Drug Delivery Using Phase Change Material</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yong%20Ren">Yong Ren</a>, <a href="https://publications.waset.org/abstracts/search?q=Yaping%20Zhang"> Yaping Zhang</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A numerical model has been developed to investigate the thermally triggered release kinetics for drug delivery using phase change material as shell of microcapsules. Biocompatible material n-Eicosane is used as demonstration. PCM shell of microcapsule will remain in solid form after the drug is taken, so the drug will be encapsulated by the shell, and will not be released until the target body part of lesion is exposed to external heat source, which will thermally trigger the release kinetics, leading to solid-to-liquid phase change. The findings can lead to better understanding on the key effects influencing the phase change process for drug delivery applications. The facile approach to release drug from core/shell structure of microcapsule can be well integrated with organic solvent free fabrication of microcapsules, using double emulsion as template in microfluidic aqueous two phase system. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=phase%20change%20material" title="phase change material">phase change material</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20release%20kinetics" title=" drug release kinetics"> drug release kinetics</a>, <a href="https://publications.waset.org/abstracts/search?q=double%20emulsion" title=" double emulsion"> double emulsion</a>, <a href="https://publications.waset.org/abstracts/search?q=microfluidics" title=" microfluidics"> microfluidics</a> </p> <a href="https://publications.waset.org/abstracts/22132/numerical-investigation-of-thermally-triggered-release-kinetics-of-double-emulsion-for-drug-delivery-using-phase-change-material" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/22132.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">357</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2965</span> Preparation and Evaluation of Zidovudine Nanoparticles</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=D.%20R.%20Rama%20Brahma%20Reddy">D. R. Rama Brahma Reddy</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Vijaya%20Sarada%20Reddy"> A. Vijaya Sarada Reddy</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Nanoparticles represent a promising drug delivery system of controlled and targeted drug release. They are specially designed to release the drug in the vicinity of target tissue. The aim of this study was to prepare and evaluate polymethacrylic acid nanoparticles containing Zidovudine in different drug to polymer ratio by nanoprecipitation method. SEM indicated that nanoparticles have a discrete spherical structure without aggregation. The average particle size was found to be 120 ± 0.02 - 420 ± 0.05 nm. The particle size of the nanoparticles was gradually increased with increase in the proportion of polymethacrylic acid polymer. The drug content of the nanoparticles was increasing on increasing polymer concentration up to a particular concentration. No appreciable difference was observed in the extent of degradation of product during 60 days in which, nanoparticles were stored at various temperatures. FT-IR studies indicated that there was no chemical interaction between drug and polymer and stability of drug. The in-vitro release behavior from all the drug loaded batches was found to be zero order and provided sustained release over a period of 24 h. The developed formulation overcome and alleviates the drawbacks and limitations of Zidovudine sustained release formulations and could possibility be advantageous in terms of increased bio availability of Zidovudine. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=nanoparticles" title="nanoparticles">nanoparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=zidovudine" title=" zidovudine"> zidovudine</a>, <a href="https://publications.waset.org/abstracts/search?q=biodegradable" title=" biodegradable"> biodegradable</a>, <a href="https://publications.waset.org/abstracts/search?q=polymethacrylic%20acid" title=" polymethacrylic acid"> polymethacrylic acid</a> </p> <a href="https://publications.waset.org/abstracts/1479/preparation-and-evaluation-of-zidovudine-nanoparticles" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/1479.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">625</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2964</span> Functionalized DOX Nanocapsules by Iron Oxide Nanoparticles for Targeted Drug Delivery</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Afsaneh%20Ghorbanzadeh">Afsaneh Ghorbanzadeh</a>, <a href="https://publications.waset.org/abstracts/search?q=Afshin%20Farahbakhsh"> Afshin Farahbakhsh</a>, <a href="https://publications.waset.org/abstracts/search?q=Zakieh%20Bayat"> Zakieh Bayat</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The drug capsulation was used for release and targeted delivery in determined time, place and temperature or pH. The DOX nanocapsules were used to reduce and to minimize the unwanted side effects of drug. In this paper, the encapsulation methods of doxorubicin (DOX) and the labeling it by the magnetic core of iron (Fe3O4) has been studied. The Fe3O4 was conjugated with DOX via hydrazine bond. The solution was capsuled by the sensitive polymer of heat or pH such as chitosan-g-poly (N-isopropylacrylamide-co-N,N-dimethylacrylamide), dextran-g-poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide) and mPEG-G2.5 PAMAM by hydrazine bond. The drug release was very slow at temperatures lower than 380°C. There was a rapid and controlled drug release at temperatures higher than 380°C. According to experiments, the use mPEG-G2.5PAMAM is the best method of DOX nanocapsules synthesis, because in this method, the drug delivery time to certain place is lower than other methods and the percentage of released drug is higher. The synthesized magnetic carrier system has potential applications in magnetic drug-targeting delivery and magnetic resonance imaging. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=drug%20carrier" title="drug carrier">drug carrier</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20release" title=" drug release"> drug release</a>, <a href="https://publications.waset.org/abstracts/search?q=doxorubicin" title=" doxorubicin"> doxorubicin</a>, <a href="https://publications.waset.org/abstracts/search?q=iron%20oxide%20NPs" title=" iron oxide NPs"> iron oxide NPs</a> </p> <a href="https://publications.waset.org/abstracts/9068/functionalized-dox-nanocapsules-by-iron-oxide-nanoparticles-for-targeted-drug-delivery" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/9068.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">417</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2963</span> Design, Development and Characterization of Pioglitazone Transdermal Drug Delivery System</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Dwarakanadha%20Reddy%20Peram">Dwarakanadha Reddy Peram</a>, <a href="https://publications.waset.org/abstracts/search?q=D.%20Swarnalatha"> D. Swarnalatha</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20Gopinath"> C. Gopinath</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The main aim of this research work was to design and development characterization of Pioglitazone transdermal drug delivery system by using various polymers such as Olibanum with different concentration by solvent evaporation technique. The prepared formulations were evaluated for different physicochemical characteristics like thickness, folding endurance, drug content, percentage moisture absorption, percentage moisture loss, percentage elongation break test and weight uniformity. The diffusion studies were performed by using modified Franz diffusion cells. The result of dissolution studies shows that formulation, F3 (Olibanum with 50 mg) showed maximum release of 99.95 % in 12hrs, whereas F1 (Olibanum and EC backing membrane) showed minimum release of 93.65% in 12 hr. Based on the drug release and physicochemical values obtained the formulation F3 is considered as an optimized formulation which shows higher percentage of drug release of 99.95 % in 12 hr. The developed transdermal patches increase the therapeutic efficacy and reduced toxic effect of pioglitazone. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=pioglitazone" title="pioglitazone">pioglitazone</a>, <a href="https://publications.waset.org/abstracts/search?q=olibanum" title=" olibanum"> olibanum</a>, <a href="https://publications.waset.org/abstracts/search?q=transdermal%20drug%20delivery%20system" title=" transdermal drug delivery system"> transdermal drug delivery system</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20release%20percantage" title=" drug release percantage"> drug release percantage</a> </p> <a href="https://publications.waset.org/abstracts/85414/design-development-and-characterization-of-pioglitazone-transdermal-drug-delivery-system" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/85414.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">208</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2962</span> Mesoporous Tussah Silk Fibroin Microspheres for Drug Delivery</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Weitao%20Zhou">Weitao Zhou</a>, <a href="https://publications.waset.org/abstracts/search?q=Qing%20Wang"> Qing Wang</a>, <a href="https://publications.waset.org/abstracts/search?q=Jianxin%20He"> Jianxin He</a>, <a href="https://publications.waset.org/abstracts/search?q=Shizhong%20Cui"> Shizhong Cui</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Mesoporous Tussah silk fibroin (TSF) spheres were fabricated via the self-assembly of TSF molecules in aqueous solutions. The results showed that TSF particles were approximately three-dimensional spheres with the diameter ranging from 500nm to 6μm without adherence. More importantly, the surface morphology is mesoporous structure with nano-pores of 20nm - 200nm in size. Fourier transform infrared (FT-IR) and X-ray diffraction (XRD) studies demonstrated that mesoporous TSF spheres mainly contained beta-sheet conformation (44.1 %) as well as slight amounts of random coil (13.2 %). Drug release test was performed with 5-fluorouracil (5-Fu) as a model drug and the result indicated the mesoporous TSF microspheres had a good capacity of sustained drug release. It is expected that these stable and high-crystallinity mesoporous TSF sphere produced without organic solvents, which have significantly improved drug release properties, is a very promising material for controlled gene medicines delivery. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Tussah%20silk%20fibroin" title="Tussah silk fibroin">Tussah silk fibroin</a>, <a href="https://publications.waset.org/abstracts/search?q=porous%20materials" title=" porous materials"> porous materials</a>, <a href="https://publications.waset.org/abstracts/search?q=microsphere" title=" microsphere"> microsphere</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20release" title=" drug release"> drug release</a> </p> <a href="https://publications.waset.org/abstracts/69674/mesoporous-tussah-silk-fibroin-microspheres-for-drug-delivery" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/69674.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">459</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2961</span> Preparation and Evaluation of Multiple Unit Tablets of Aceclofenac</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Vipin%20Saini">Vipin Saini</a>, <a href="https://publications.waset.org/abstracts/search?q=Sunil%20Kamboj"> Sunil Kamboj</a>, <a href="https://publications.waset.org/abstracts/search?q=Suman%20Bala"> Suman Bala</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Pandurangan"> A. Pandurangan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The present research is aimed at fabrication of multiple-unit controlled-release tablet formulation of aceclofenac by employing acrylic polymers as the release controlling excipients for drug multi-particulates to achieve the desired objectives of maintaining the same controlled release characteristics as that prior to their compression into tablet. Various manufacturers are successfully manufacturing and marketing aceclofenac controlled release tablet by applying directly coating materials on the tablet. The basic idea behind development of such formulations was to employ aqueous acrylics polymers dispersion as an alternative to the existing approaches, wherein the forces of compression may cause twist of drug pellets, but do not have adverse effects on the drug release properties. Thus, the study was undertaken to illustrate manufacturing of controlled release aceclofenac multiple-unit tablet formulation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=aceclofenac" title="aceclofenac">aceclofenac</a>, <a href="https://publications.waset.org/abstracts/search?q=multiple-unit%20tablets" title=" multiple-unit tablets"> multiple-unit tablets</a>, <a href="https://publications.waset.org/abstracts/search?q=acrylic%20polymers" title=" acrylic polymers"> acrylic polymers</a>, <a href="https://publications.waset.org/abstracts/search?q=controlled-release" title=" controlled-release"> controlled-release</a> </p> <a href="https://publications.waset.org/abstracts/1518/preparation-and-evaluation-of-multiple-unit-tablets-of-aceclofenac" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/1518.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">442</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2960</span> Development of Oral Biphasic Drug Delivery System Using a Natural Resourced Polymer, Terminalia catappa</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Venkata%20Srikanth%20Meka">Venkata Srikanth Meka</a>, <a href="https://publications.waset.org/abstracts/search?q=Nur%20Arthirah%20Binti%20Ahmad%20Tarmizi%20Tan"> Nur Arthirah Binti Ahmad Tarmizi Tan</a>, <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20Syahmi%20Bin%20Md%20Nazir"> Muhammad Syahmi Bin Md Nazir</a>, <a href="https://publications.waset.org/abstracts/search?q=Adinarayana%20Gorajana"> Adinarayana Gorajana</a>, <a href="https://publications.waset.org/abstracts/search?q=Senthil%20Rajan%20Dharmalingam"> Senthil Rajan Dharmalingam</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Biphasic drug delivery systems are designed to release drug at two different rates, either fast/prolonged or prolonged/fast. A fast/prolonged release system provides a burst drug release at initial stage followed by a slow release over a prolonged period of time and in case of prolonged/fast release system, the release pattern is vice versa. Terminalia catappa gum (TCG) is a natural polymer and was successfully proven as a novel pharmaceutical excipient. The main objective of the present research is to investigate the applicability of natural polymer, Terminalia catappa gum in the design of oral biphasic drug delivery system in the form of mini tablets by using a model drug, buspirone HCl. This investigation aims to produce a biphasic release drug delivery system of buspirone by combining immediate release and prolonged release mini tablets into a capsule. For immediate release mini tablets, a dose of 4.5 mg buspirone was prepared by varying the concentration of superdisintegrant; crospovidone. On the other hand, prolonged release mini tablets were produced by using different concentrations of the natural polymer; TCG with a buspirone dose of 3mg. All mini tablets were characterized for weight variation, hardness, friability, disintegration, content uniformity and dissolution studies. The optimized formulations of immediate and prolonged release mini tablets were finally combined in a capsule and was evaluated for release studies. FTIR and DSC studies were conducted to study the drug-polymer interaction. All formulations of immediate release and prolonged release mini tablets were passed all the in-process quality control tests according to US Pharmacopoeia. The disintegration time of immediate release mini tablets of different formulations was varied from 2-6 min, and maximum drug release was achieved in lesser than 60 min. Whereas prolonged release mini tablets made with TCG have shown good drug retarding properties. Formulations were controlled for about 4-10 hrs with varying concentration of TCG. As the concentration of TCG increased, the drug release retarding property also increased. The optimised mini tablets were packed in capsules and were evaluated for the release mechanism. The capsule dosage form has clearly exhibited the biphasic release of buspirone, indicating that TCG is a suitable natural polymer for this study. FTIR and DSC studies proved that there was no interaction between the drug and polymer. Based on the above positive results, it can be concluded that TCG is a suitable polymer for the biphasic drug delivery systems. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Terminalia%20catappa%20gum" title="Terminalia catappa gum">Terminalia catappa gum</a>, <a href="https://publications.waset.org/abstracts/search?q=biphasic%20release" title=" biphasic release"> biphasic release</a>, <a href="https://publications.waset.org/abstracts/search?q=mini%20tablets" title=" mini tablets"> mini tablets</a>, <a href="https://publications.waset.org/abstracts/search?q=tablet%20in%20capsule" title=" tablet in capsule"> tablet in capsule</a>, <a href="https://publications.waset.org/abstracts/search?q=natural%20polymers" title=" natural polymers"> natural polymers</a> </p> <a href="https://publications.waset.org/abstracts/50516/development-of-oral-biphasic-drug-delivery-system-using-a-natural-resourced-polymer-terminalia-catappa" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/50516.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">393</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2959</span> Effect of Alginate and Surfactant on Physical Properties of Oil Entrapped Alginate Bead Formulation of Curcumin</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Arpa%20Petchsomrit">Arpa Petchsomrit</a>, <a href="https://publications.waset.org/abstracts/search?q=Namfa%20Sermkaew"> Namfa Sermkaew</a>, <a href="https://publications.waset.org/abstracts/search?q=Ruedeekorn%20Wiwattanapatapee"> Ruedeekorn Wiwattanapatapee</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Oil entrapped floating alginate beads of curcumin were developed and characterized. Cremophor EL, Cremophor RH and Tween 80 were utilized to improve the solubility of the drug. The oil-loaded floating gel beads prepared by emulsion gelation method contained sodium alginate, mineral oil and surfactant. The drug content and % encapsulation declined as the ratio of surfactant was increased. The release of curcumin from 1% alginate beads was significantly more than for the 2% alginate beads. The drug released from the beads containing 25% of tween 80 was about 70% while a higher drug release was observed with the beads containing Cremophor EL or Cremohor RH (approximately 90%). The developed floating beads of curcumin powder with surfactant provided a superior drug release than those without surfactant. Floating beads based on oil entrapment containing the drug solubilized in surfactants is a new delivery system to enhance the dissolution of poorly soluble drugs. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=alginate" title="alginate">alginate</a>, <a href="https://publications.waset.org/abstracts/search?q=curcumin" title=" curcumin"> curcumin</a>, <a href="https://publications.waset.org/abstracts/search?q=floating%20drug%20delivery" title=" floating drug delivery"> floating drug delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=oil%20entrapped%20bead" title=" oil entrapped bead"> oil entrapped bead</a> </p> <a href="https://publications.waset.org/abstracts/3633/effect-of-alginate-and-surfactant-on-physical-properties-of-oil-entrapped-alginate-bead-formulation-of-curcumin" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/3633.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">385</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2958</span> Development and Evaluation of Gastro Retentive Floating Tablets of Ayurvedic Vati Formulation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Imran%20Khan%20Pathan">Imran Khan Pathan</a>, <a href="https://publications.waset.org/abstracts/search?q=Anil%20Bhandari"> Anil Bhandari</a>, <a href="https://publications.waset.org/abstracts/search?q=Peeyush%20K.%20Sharma"> Peeyush K. Sharma</a>, <a href="https://publications.waset.org/abstracts/search?q=Rakesh%20K.%20Patel"> Rakesh K. Patel</a>, <a href="https://publications.waset.org/abstracts/search?q=Suresh%20Purohit"> Suresh Purohit</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Floating tablets of Marichyadi Vati were developed with an aim to prolong its gastric residence time and increase the bioavailability of drug. Rapid gastrointestinal transit could result in incomplete drug release from the drug delivery system above the absorption zone leading to diminished efficacy of the administered dose. The tablets were prepared by wet granulation technique, using HPMC E50 LV act as Matrixing agent, Carbopol as floating enhancer, microcrystalline cellulose as binder, sodium bi carbonate as effervescent agent with other excipients. The simplex lattice design was used for selection of variables for tablets formulation. Formulation was optimized on the basis of floating time and in vitro drug release. The results showed that the floating lag time for optimized formulation was found to be 61 second with about 97.32 % of total drug release within 3 hours. The in vitro release profiles of drug from the formulation could be best expressed zero order with highest linearity r2 = 0.9943. It was concluded that the gastroretentive drug delivery system can be developed for Marichyadi Vati containing piperine to increase the residence time of the drug in the stomach and thereby increasing bioavailability. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=piperine" title="piperine">piperine</a>, <a href="https://publications.waset.org/abstracts/search?q=Marichyadi%20Vati" title=" Marichyadi Vati"> Marichyadi Vati</a>, <a href="https://publications.waset.org/abstracts/search?q=gastroretentive%20drug%20delivery" title=" gastroretentive drug delivery"> gastroretentive drug delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=floating%20tablet" title=" floating tablet"> floating tablet</a> </p> <a href="https://publications.waset.org/abstracts/1702/development-and-evaluation-of-gastro-retentive-floating-tablets-of-ayurvedic-vati-formulation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/1702.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">457</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2957</span> Novel IPN Hydrogel Beads as pH Sensitive Drug Delivery System for an Anti-Ulcer Drug</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Vishal%20Kumar%20Gupta">Vishal Kumar Gupta</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Purpose: This study has been undertaken to develop novel pH sensitive interpenetrating network hydrogel beads. Methods: The pH sensitive PAAM-g-Guar gum copolymer was synthesized by free radical polymerization followed by alkaline hydrolysis. Beads of guar gum-grafted-polyacrylamide and sodium Carboxy methyl cellulose (Na CMC) loaded with Pantoprazole sodium were prepared and evaluated for pH sensitivity, swelling properties, drug entrapment efficiency and in vitro drug release characteristics. Seven formulations were prepared for the drug with varying polymer and cross linker concentrations. Results: The grafting and alkaline hydrolysis reactions were confirmed by FT-IR spectroscopy. Differential scanning calorimetry was carried out to know the compatibility of encapsulated drug with the polymers. Scanning electron microscopic study revealed that the IPN beads were spherical. The entrapment efficiency was found to be in the range of 85-92%. Particle size analysis was carried out by optical microscopy. As the pH of the medium was changed from 1.2 to 7.4, a considerable increase in swelling was observed for all beads. Increase in the copolymer concentration showed sustained the drug release up to 12 hrs. Drug release from the beads followed super case II transport mechanism. Conclusion: It was concluded that guar gum-acrylamide beads, cross-linked with aluminum chloride offer an opportunity for controlled drug release of pantoprazole sodium. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=IPN" title="IPN">IPN</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrogels" title=" hydrogels"> hydrogels</a>, <a href="https://publications.waset.org/abstracts/search?q=DSC" title=" DSC"> DSC</a>, <a href="https://publications.waset.org/abstracts/search?q=SEM" title=" SEM"> SEM</a> </p> <a href="https://publications.waset.org/abstracts/8471/novel-ipn-hydrogel-beads-as-ph-sensitive-drug-delivery-system-for-an-anti-ulcer-drug" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/8471.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">269</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2956</span> Controlled Release of Glucosamine from Pluronic-Based Hydrogels for the Treatment of Osteoarthritis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Papon%20Thamvasupong">Papon Thamvasupong</a>, <a href="https://publications.waset.org/abstracts/search?q=Kwanchanok%20Viravaidya-Pasuwat"> Kwanchanok Viravaidya-Pasuwat</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Osteoarthritis affects a lot of people worldwide. Local injection of glucosamine is one of the alternative treatment methods to replenish the natural lubrication of cartilage. However, multiple injections can potentially lead to possible bacterial infection. Therefore, a drug delivery system is desired to reduce the frequencies of injections. A hydrogel is one of the delivery systems that can control the release of drugs. Thermo-reversible hydrogels can be beneficial to the drug delivery system especially in the local injection route because this formulation can change from liquid to gel after getting into human body. Once the gel is in the body, it will slowly release the drug in a controlled manner. In this study, various formulations of Pluronic-based hydrogels were synthesized for the controlled release of glucosamine. One of the challenges of the Pluronic controlled release system is its fast dissolution rate. To overcome this problem, alginate and calcium sulfate (CaSO<sub>4</sub>) were added to the polymer solution. The characteristics of the hydrogels were investigated including the gelation temperature, gelation time, hydrogel dissolution and glucosamine release mechanism. Finally, a mathematical model of glucosamine release from Pluronic-alginate-hyaluronic acid hydrogel was developed. Our results have shown that crosslinking Pluronic gel with alginate did not significantly extend the dissolution rate of the gel. Moreover, the gel dissolution profiles and the glucosamine release mechanisms were best described using the zeroth-order kinetic model, indicating that the release of glucosamine was primarily governed by the gel dissolution. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=controlled%20release" title="controlled release">controlled release</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20delivery%20system" title=" drug delivery system"> drug delivery system</a>, <a href="https://publications.waset.org/abstracts/search?q=glucosamine" title=" glucosamine"> glucosamine</a>, <a href="https://publications.waset.org/abstracts/search?q=pluronic" title=" pluronic"> pluronic</a>, <a href="https://publications.waset.org/abstracts/search?q=thermoreversible%20hydrogel" title=" thermoreversible hydrogel"> thermoreversible hydrogel</a> </p> <a href="https://publications.waset.org/abstracts/51314/controlled-release-of-glucosamine-from-pluronic-based-hydrogels-for-the-treatment-of-osteoarthritis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/51314.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">270</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2955</span> Development and Characterization of Controlled Release Photo Cross-Linked Implants for Ocular Delivery of Triamcinolone Acetonide</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ravi%20Sheshala">Ravi Sheshala</a>, <a href="https://publications.waset.org/abstracts/search?q=Annie%20Lee"> Annie Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Ai%20Lin%20Ong"> Ai Lin Ong</a>, <a href="https://publications.waset.org/abstracts/search?q=Ling%20Ling%20Cheu"> Ling Ling Cheu</a>, <a href="https://publications.waset.org/abstracts/search?q=Thiagarajan%20Madheswaran"> Thiagarajan Madheswaran</a>, <a href="https://publications.waset.org/abstracts/search?q=Thankur%20R.%20R.%20Singh"> Thankur R. R. Singh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The objectives of the present research work were to develop and characterize biodegradable controlled release photo cross-linked implants of Triamcinolone Acetonide (TA) for the treatment of chronic ocular diseases. The photo cross-linked implants were prepared using film casting technique by mixing TA (2.5%) polyethylene glycol diacrylate (PEGDA 700), pore formers (mannitol, maltose, and gelatin) and the photoinitiator (Irgacure 2959). The resulting mixture was injected into moulds using 21 G and subjected to photocrosslinking at 365 nm. Scanning electron microscopy results demonstrated that more pores were formed in the films with the increase in the concentration of pore formers from 2%-10%. The maximum force required to break the films containing 2-10% of pore formers were determined in both dry and wet conditions using texture analyzer and found that films in a dry condition required a higher force to break compared to wet condition and blank films. In vitro drug release from photo cross-linked films were determined by incubating samples in 50 ml PBS pH 7.4 at 37 C and the samples were analyzed for drug release by HPLC. The films demonstrated a biphasic release profile i.e. an initial burst release (<20%) on the first day followed by a constant and continuous drug release in a controlled manner for 42 days. The drug release from all formulations followed the first-order release pattern and the combination of diffusion and erosion release mechanism. In conclusion, the developed formulations were able to provide controlled drug delivery to treat the chronic ocular diseases. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=controlled%20release" title="controlled release">controlled release</a>, <a href="https://publications.waset.org/abstracts/search?q=ophthalmic" title=" ophthalmic"> ophthalmic</a>, <a href="https://publications.waset.org/abstracts/search?q=PEGDA" title=" PEGDA"> PEGDA</a>, <a href="https://publications.waset.org/abstracts/search?q=photocrosslinking" title=" photocrosslinking"> photocrosslinking</a>, <a href="https://publications.waset.org/abstracts/search?q=pore%20formers" title=" pore formers"> pore formers</a> </p> <a href="https://publications.waset.org/abstracts/51380/development-and-characterization-of-controlled-release-photo-cross-linked-implants-for-ocular-delivery-of-triamcinolone-acetonide" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/51380.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">404</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2954</span> Formulation, Evaluation and Statistical Optimization of Transdermal Niosomal Gel of Atenolol</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lakshmi%20Sirisha%20Kotikalapudi">Lakshmi Sirisha Kotikalapudi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Atenolol, the widely used antihypertensive drug is ionisable and degrades in the acidic environment of the GIT lessening the bioavailability. Transdermal route may be selected as an alternative to enhance the bioavailability. Half-life of the drug is 6-7 hours suggesting the requirement of prolonged release of the drug. The present work of transdermal niosomal gel aims to extend release of the drug and increase the bioavailability. Ethanol injection method was used for the preparation of niosomes using span-60 and cholesterol at different molar ratios following central composite design. The prepared niosomes were characterized for size, zeta-potential, entrapment efficiency, drug content and in-vitro drug release. Optimized formulation was selected by statistically analyzing the results obtained using the software Stat-Ease Design Expert. The optimized formulation also showed high drug retention inside the vesicles over a period of three months at a temperature of 4 °C indicating stability. Niosomes separated as a pellet were dried and incorporated into the hydrogel prepared using chitosan a natural polymer as a gelling agent. The effect of various chemical permeation enhancers was also studied over the gel formulations. The prepared formulations were characterized for viscosity, pH, drug release using Franz diffusion cells, and skin irritation test as well as in-vivo pharmacological activities. Atenolol niosomal gel preparations showed the prolonged release of the drug and pronounced antihypertensive activity indicating the suitability of niosomal gel for topical and systemic delivery of atenolol. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=atenolol" title="atenolol">atenolol</a>, <a href="https://publications.waset.org/abstracts/search?q=chitosan" title=" chitosan"> chitosan</a>, <a href="https://publications.waset.org/abstracts/search?q=niosomes" title=" niosomes"> niosomes</a>, <a href="https://publications.waset.org/abstracts/search?q=transdermal" title=" transdermal"> transdermal</a> </p> <a href="https://publications.waset.org/abstracts/59549/formulation-evaluation-and-statistical-optimization-of-transdermal-niosomal-gel-of-atenolol" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/59549.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">294</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2953</span> Tunable Control of Therapeutics Release from the Nanochannel Delivery System (nDS) </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Thomas%20Geninatti">Thomas Geninatti</a>, <a href="https://publications.waset.org/abstracts/search?q=Bruno%20Giacomo"> Bruno Giacomo</a>, <a href="https://publications.waset.org/abstracts/search?q=Alessandro%20Grattoni"> Alessandro Grattoni</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Nanofluidic devices have been investigated for over a decade as promising platforms for the controlled release of therapeutics. The nanochannel drug delivery system (nDS), a membrane fabricated with high precision silicon techniques, capable of zero-order release of drugs by exploiting diffusion transport at the nanoscale originated from the interactions between molecules with nanochannel surfaces, showed the flexibility of the sustained release in vitro and in vivo, over periods of time ranging from weeks to months. To improve the implantable bio nanotechnology, in order to create a system that possesses the key features for achieve the suitable release of therapeutics, the next generation of nDS has been created. Platinum electrodes are integrated by e-beam deposition onto both surfaces of the membrane allowing low voltage (<2 V) and active temporal control of drug release through modulation of electrostatic potentials at the inlet and outlet of the membrane’s fluidic channels. Hence, a tunable administration of drugs is ensured from the nanochannel drug delivery system. The membrane will be incorporated into a peek implantable capsule, which will include drug reservoir, control hardware and RF system to allow suitable therapeutic regimens in real-time. Therefore, this new nanotechnology offers tremendous potential solutions to manage chronic disease such as cancer, heart disease, circadian dysfunction, pain and stress. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=nanochannel%20membrane" title="nanochannel membrane">nanochannel membrane</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20delivery" title=" drug delivery"> drug delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=tunable%20release" title=" tunable release"> tunable release</a>, <a href="https://publications.waset.org/abstracts/search?q=personalized%20administration" title=" personalized administration"> personalized administration</a>, <a href="https://publications.waset.org/abstracts/search?q=nanoscale%20transport" title=" nanoscale transport"> nanoscale transport</a>, <a href="https://publications.waset.org/abstracts/search?q=biomems" title=" biomems"> biomems</a> </p> <a href="https://publications.waset.org/abstracts/15827/tunable-control-of-therapeutics-release-from-the-nanochannel-delivery-system-nds" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/15827.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">314</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2952</span> Formulation and Evaluation of Niosomes Containing an Antihypertensive Drug</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sunil%20Kamboj">Sunil Kamboj</a>, <a href="https://publications.waset.org/abstracts/search?q=Suman%20Bala"> Suman Bala</a>, <a href="https://publications.waset.org/abstracts/search?q=Vipin%20Saini"> Vipin Saini</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Niosomes were formulated with an aim of enhancing the oral bioavailability of losartan potassium and formulated in different molar ratios of surfactant, cholesterol and dicetyl phosphate. The formulated niosomes were found in range of 54.98 µm to 107.85 µm in size. Formulations with 1:1 ratio of surfactant and cholesterol have shown maximum entrapment efficiencies. Niosomes with sorbitan monostearate showed maximum drug release and zero order release kinetics, at the end of 24 hours. The <em>in vivo</em> study has shown the significant enhancement in oral bioavailability of losartan potassium in rats, after a dose of 10 mg/kg. The average relative bioavailability in relation with pure drug solution was found 2.56, indicates more than two fold increase in oral bioavailability. A significant increment in MRT reflects the release retarding ability of the vesicles. In conclusion, niosomes could be a promising delivery of losartan potassium with improved oral bioavailability and prolonged release profiles. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=non-ionic%20surfactant%20vesicles" title="non-ionic surfactant vesicles">non-ionic surfactant vesicles</a>, <a href="https://publications.waset.org/abstracts/search?q=losartan%20potassium" title=" losartan potassium"> losartan potassium</a>, <a href="https://publications.waset.org/abstracts/search?q=oral%20bioavailability" title=" oral bioavailability"> oral bioavailability</a>, <a href="https://publications.waset.org/abstracts/search?q=controlled%20release" title=" controlled release"> controlled release</a> </p> <a href="https://publications.waset.org/abstracts/37426/formulation-and-evaluation-of-niosomes-containing-an-antihypertensive-drug" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/37426.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">354</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2951</span> Preparation and Characterization of Nano-Metronidazole by Planetary Ball-Milling</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Shahriar%20Ghammamy">Shahriar Ghammamy</a>, <a href="https://publications.waset.org/abstracts/search?q=Maryam%20Gholipoor"> Maryam Gholipoor</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Metronidazole nano -powders with the average mean particle size around 90 nm were synthesized by high-energy milling using a planetary ball mill is provided. The Scattering factors, milling of time,the ball size and ball to powder ratio on the material properties powder by the Ray diffraction (XRD) study, scanning electron microscopy (SEM), IR. It has been observed that the density of nano-sized grinding balls as ball to powder ratio depends. Using the dispersion factor, the density Can be reduced below the initial particle size was achieved. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=metronidazole" title="metronidazole">metronidazole</a>, <a href="https://publications.waset.org/abstracts/search?q=ball-milling" title=" ball-milling"> ball-milling</a>, <a href="https://publications.waset.org/abstracts/search?q=nanoparticles" title=" nanoparticles"> nanoparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=characterization" title=" characterization"> characterization</a>, <a href="https://publications.waset.org/abstracts/search?q=XRD%20diffraction" title=" XRD diffraction"> XRD diffraction</a> </p> <a href="https://publications.waset.org/abstracts/16630/preparation-and-characterization-of-nano-metronidazole-by-planetary-ball-milling" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/16630.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">401</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2950</span> Preparation, Characterization, and in-Vitro Drug Release Study of Methotrexate-Loaded Hydroxyapatite-Sodium Alginate Nanocomposites</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Friday%20G.%20Okibe">Friday G. Okibe</a>, <a href="https://publications.waset.org/abstracts/search?q=Edit%20B.%20Agbaji"> Edit B. Agbaji</a>, <a href="https://publications.waset.org/abstracts/search?q=Victor%20O.%20Ajibola"> Victor O. Ajibola</a>, <a href="https://publications.waset.org/abstracts/search?q=Christain%20C.%20Onoyima"> Christain C. Onoyima</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Controlled drug delivery systems reduce dose-dependent toxicity associated with potent drugs, including anticancer drugs. In this research, hydroxyapatite (HA) and hydroxyapatite-sodium alginate nanocomposites (HASA) were successfully prepared and characterized using Fourier Transform Infrared spectroscopy (FTIR) and Scanning Electron Microscopy (SEM). The FTIR result showed absorption peaks characteristics of pure hydroxyapatite (HA), and also confirmed the chemical interaction between hydroxyapatite and sodium alginate in the formation of the composite. Image analysis from SEM revealed nano-sized hydroxyapatite and hydroxyapatite-sodium alginate nanocomposites with irregular morphologies. Particle size increased with the formation of the nanocomposites relative to pure hydroxyapatite, with no significant change in particles morphologies. Drug loading and in-vitro drug release study were carried out using synthetic body fluid as the release medium, at pH 7.4 and 37 °C and under perfect sink conditions. The result shows that drug loading is highest for pure hydroxyapatite and decreased with increasing quantity of sodium alginate. However, the release study revealed that HASA-5%wt and HASA-20%wt presented better release profile than pure hydroxyapatite, while HASA-33%wt and HASA-50%wt have poor release profiles. This shows that Methotrexate-loaded hydroxyapatite-sodium alginate if prepared under optimal conditions is a potential carrier for effective delivery of Methotrexate. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=drug-delivery" title="drug-delivery">drug-delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=hydroxyapatite" title=" hydroxyapatite"> hydroxyapatite</a>, <a href="https://publications.waset.org/abstracts/search?q=methotrexate" title=" methotrexate"> methotrexate</a>, <a href="https://publications.waset.org/abstracts/search?q=nanocomposites" title=" nanocomposites"> nanocomposites</a>, <a href="https://publications.waset.org/abstracts/search?q=sodium%20alginate" title=" sodium alginate"> sodium alginate</a> </p> <a href="https://publications.waset.org/abstracts/53235/preparation-characterization-and-in-vitro-drug-release-study-of-methotrexate-loaded-hydroxyapatite-sodium-alginate-nanocomposites" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/53235.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">277</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=drug%20release%20metronidazole&page=2">2</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=drug%20release%20metronidazole&page=3">3</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=drug%20release%20metronidazole&page=4">4</a></li> <li class="page-item"><a class="page-link" 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