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}) })(jQuery); </script> </head> <body class="post-template-default single single-post postid-390 single-format-standard header-image header-full-width full-width-content genesis-breadcrumbs-hidden"><div class="site-container"><header class="site-header"><div class="wrap"><div class="title-area"><p class="site-title"><a href="https://www.thermofisher.com/" title="Thermo Fisher Scientific">Thermo Fisher Scientific</a></p><p class="site-description">Molecular testing content for clinical lab professionals and clinicians</p></div></div></header> <nav role="navigation" class="top-menu tm" style=""> <ul> <li><a href="#" aria-haspopup="true">Categories<div data-uw-styling-context="true"><b data-uw-styling-context="true"></b></div></a> <ul class="dropdown" aria-label="submenu"> <li><a href=" https://www.thermofisher.com/blog/clinical-conversations/science-and-education/">Science and education</a></li> <li><a href=" https://www.thermofisher.com/blog/clinical-conversations/product-news/">Product news</a></li> <li><a href=" https://www.thermofisher.com/blog/clinical-conversations/case-studies/">Case studies</a></li> <li><a href=" https://www.thermofisher.com/blog/clinical-conversations/perspectives/">Perspectives</a></li> <li><a href=" https://www.thermofisher.com/blog/clinical-conversations/events/">Events</a></li> <li><a href=" https://www.thermofisher.com/blog/clinical-conversations/news/">News</a></li> </ul> </li> </ul> </nav> <div class="site-inner"><div class="content-sidebar-wrap"><main class="content"><article class="post-390 post type-post status-publish format-standard has-post-thumbnail category-science-and-education tag-content-video tag-covid-19 tag-mutations tag-sars-cov-2 tag-sgtf entry" aria-label="The importance of assay design in the face of SARS-CoV-2 mutations"><header class="entry-header"><h1 class="entry-title">The importance of assay design in the face of SARS-CoV-2 mutations</h1> <script type="text/javascript"> function cc_toggle(id){ var s = document.getElementById(id); if(isHidden(s)){ s.style.display = 'inline'; } else { s.style.display = 'none'; } } function isHidden(element){ var style = window.getComputedStyle(element); return (style.display === 'none'); } </script> <span class="cc_sidebar"> <span class="cc_color_bar"> <span class="cc_home_icon"> <a href="https://www.thermofisher.com/blog/clinical-conversations/"><img src="https://www.thermofisher.com/blog/clinical-conversations/wp-content/themes/clinical-conversations/images/icon_home.png" alt="Clinical Conversation blog - home icon" /></a> </span> <span class="cc_post_category"> <a class='cc_colorbar_category' href='https://www.thermofisher.com/blog/clinical-conversations/category/science-and-education/'>Science and education</a> </span>  <span id="cc_post_readtime"> 2 mins. </span> <span class="cc_toggle_social"> <a href="javascript:cc_toggle('cc_jetpack_shares');">Sharing ▼</a> </span> <span class="cc_toggle"> <a href="javascript:cc_toggle('cc_metadata');">Details ▼</a> </span> </span> </span> <span id="cc_jetpack_shares"> <ul> <li><a target="_blank" href='https://www.linkedin.com/shareArticle?mini=true&url=https%3A%2F%2Fwww.thermofisher.com%2Fblog%2Fclinical-conversations%2Fthe-importance-of-assay-design-in-the-face-of-sars-cov-2-mutations-2%2F&title=The+importance+of+assay+design+in+the+face+of+SARS-CoV-2+mutations'><img src="https://www.thermofisher.com/blog/clinical-conversations//wp-content/themes/clinical-conversations/images/social_icons_linkedin.jpg" alt="Linked In sharing icon" /></a></li> <li><a target="_blank" href='https://www.facebook.com/sharer/sharer.php?u=https%3A%2F%2Fwww.thermofisher.com%2Fblog%2Fclinical-conversations%2Fthe-importance-of-assay-design-in-the-face-of-sars-cov-2-mutations-2%2F'><img src="https://www.thermofisher.com/blog/clinical-conversations//wp-content/themes/clinical-conversations/images/social_icons_facebook.jpg" alt="Facebook sharing icon" /></a></li> <li><a target="_blank" href='https://twitter.com/intent/tweet?text=The+importance+of+assay+design+in+the+face+of+SARS-CoV-2+mutations&url=https%3A%2F%2Fwww.thermofisher.com%2Fblog%2Fclinical-conversations%2Fthe-importance-of-assay-design-in-the-face-of-sars-cov-2-mutations-2%2F&'><img src="https://www.thermofisher.com/blog/clinical-conversations//wp-content/themes/clinical-conversations/images/social_icons_twitter.jpg" alt="Twitter sharing icon" /></a></li> <li><a href='mailto:?subject=You might be interested in The importance of assay design in the face of SARS-CoV-2 mutations from the Clinical Conversations blog.&body=You might be interested in The importance of assay design in the face of SARS-CoV-2 mutations from the Clinical Conversations blog at https%3A%2F%2Fwww.thermofisher.com%2Fblog%2Fclinical-conversations%2Fthe-importance-of-assay-design-in-the-face-of-sars-cov-2-mutations-2%2F'><img src="https://www.thermofisher.com/blog/clinical-conversations/wp-content/themes/clinical-conversations/images/icon_email.png" alt="Email sharing icon" /></a></li> </ul> </span> <span id="cc_metadata"> <span class="cc_dateline"> <span class="post-info-date">  19 Jan 2021 </span> || <span class="post-info-author">   By Manoj Gandhi, M.D., Ph.D. </span> </span> <span class="cc_shares"> <span class="cc_shares_subhead" >Shares: <span class="share_count">0</span> </span> </span> <span class="cc_version"> <span class="cc_version_subhead">Versions of this article</span> Original article. </span> <span class="cc_post_tags"> <span class="cc_post_tags_subhead">Tags</span> <a href='https://www.thermofisher.com/blog/clinical-conversations/tag/covid-19/'>COVID-19</a>, <a href='https://www.thermofisher.com/blog/clinical-conversations/tag/mutations/'>Mutations</a>, <a href='https://www.thermofisher.com/blog/clinical-conversations/tag/sars-cov-2/'>Sars-cov-2</a>, <a href='https://www.thermofisher.com/blog/clinical-conversations/tag/sgtf/'>SGTF</a> </span>   </span> <script type="text/javascript"> cc_toggle('cc_metadata'); cc_toggle('cc_jetpack_shares'); </script> </header><div class="entry-content"><p style="text-align: left"><em>This blog represents the most up-to-date information about SARS-CoV-2 variants as of January 19, 2021.</em></p> <p class="p1">It鈥檚 a known fact that viruses mutate all the time, and it was no surprise that SARS-CoV-2 was no exception. However, there are whole host of issues that arise when the impact of these mutations is global, and it involves a novel coronavirus crisis. When news of the <a href="https://www.thermofisher.com/us/en/home/clinical/clinical-genomics/pathogen-detection-solutions/covid-19-sars-cov-2/mutations-variants.html"><span class="s1">B.1.1.7 </span><span class="s1">lineage </span></a>(aka 501Y.V1 or UK variant) and <a href="https://www.thermofisher.com/us/en/home/clinical/clinical-genomics/pathogen-detection-solutions/covid-19-sars-cov-2/mutations-variants.html"><span class="s1">B.1.351 lineage </span></a>(aka 501Y.V2 or South African variant) broke, it was obvious that scientists would ponder the impact to current <a href="https://www.thermofisher.com/us/en/home/clinical/clinical-genomics/pathogen-detection-solutions/covid-19-sars-cov-2/multiplex.html"><span class="s1">TaqPath COVID-19 </span>tests</a><span class="s2">.</span></p> <p><iframe title="Assay design in the face of SARS-CoV-2 mutations" width="760" height="428" src="https://www.youtube.com/embed/wlMo-vLqmV8?feature=oembed" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture" allowfullscreen></iframe></p> <p class="p1">The good news is that assay performance should not be impacted, and in this video, Manoj Gandhi, Sr. Director of Medical Affairs at Thermo Fisher Scientific, discusses the company鈥檚 approach to infectious disease assay design. He mentions how the assay team was able to lean on their expertise with past outbreaks such as Zika, SARS and MERS during the onset of developing the coronavirus assay. This led to a design that embraces genomic conservation, redundancy and produces an assay that is specific and sensitive.</p> <h2 class="p1">How to learn more</h2> <p class="p1">Thermo Fisher Scientific is committed to providing our global customers with gold-standard molecular technology. We regularly monitor post-market reports and public database updates to provide quality and accurate products. If you鈥檇 like more details about the impact of the 69-70del S gene mutation observed in the VUI- 202012/01 or B.1.1.7 variant on our TaqPath COVID-19 tests, please download our detailed FAQ document for the products currently available in your country:</p> <ul> <li class="p1"><a href="https://assets.thermofisher.com/TFS-Assets/GSD/Reference-Materials/69-70del-s-gene-mutation-ceivd-faq.pdf">FAQ for our CE-IVD marked tests</a></li> <li class="p1"><a href="https://assets.thermofisher.com/TFS-Assets/GSD/Reference-Materials/69-70del-s-gene-mutation-eua-faq.pdf">FAQ for our Emergency Use Authorized (EUA) test</a></li> </ul> <p class="p1">If you have additional questions or would like to discuss your specific situation, please contact our technical support team at <span class="s1">www.thermofisher.com/contactus</span>.</p>  </div></article></main></div></div><footer class="site-footer"><div class="wrap"><div class="creds"><p class="footer-links"><a href="https://corporate.thermofisher.com/en/footer/privacy-statement.html" target="_blank" rel="noopener noreferrer">Privacy Statement</a><a href="https://corporate.thermofisher.com/en/footer/terms-and-conditions.html" target="_blank" rel="noopener noreferrer">Terms & Conditions</a><a href="/blog/locations/">Locations</a><a href="/blog/sitemap/">Sitemap</a></p><p>© 2024 <a href="https://www.thermofisher.com">Thermo Fisher Scientific</a>. 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