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Aspirin useful as adjunctive treatment for giant cell arteritis | Ocular Surgery News

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id="breadcrumbs"> <a href="/web/20130903024750/http://www.healio.com/"> Healio</a> <span>&#8250;</span> <a href="/web/20130903024750/http://www.healio.com/ophthalmology"> Ophthalmology</a> <span>&#8250;</span> <a href="/web/20130903024750/http://www.healio.com/ophthalmology/neurosciences"> Neurosciences</a> <span>&#8250;</span> <a href="/web/20130903024750/http://www.healio.com/ophthalmology/neurosciences/news"> News</a> </p> <!-- /breadcrumbs --> <!-- related links --> <!--googleoff: index--><div id="SeeAlso" class="related-links"><h3>See Also</h3><ul><li><a href="https://web.archive.org/web/20130903024750/http://www.healio.com/ophthalmology/neurosciences/news/print/ocular-surgery-news/%7B70800b6e-8c0f-4363-982d-639d1bafe628%7D/giant-cell-arteritis-cluster-suggests-possible-link-to-localized-toxic-contamination">Giant cell arteritis cluster suggests possible link to localized ...</a></li><li><a href="https://web.archive.org/web/20130903024750/http://www.healio.com/ophthalmology/neurosciences/news/online/%7B5680d839-e381-4cea-932d-e0c8497b8ecd%7D/study-of-giant-cell-arteritis-rates-largest-ever-conducted-in-us-researcher-says">Study of giant cell arteritis rates largest ever conducted in US ...</a></li><li><a href="https://web.archive.org/web/20130903024750/http://www.healio.com/ophthalmology/neurosciences/news/print/ocular-surgery-news/%7B59e5a98c-8088-438f-bcfb-55d57a36960d%7D/neuroprotection-may-become-an-alternative-treatment-for-glaucoma">Neuroprotection may become an alternative treatment for ...</a></li></ul></div><!-- /related links --><!--googleon: index> <!-- /related links --> <!-- content --> <div class="content"> <h2> Aspirin useful as adjunctive treatment for giant cell arteritis</h2> <h3 class="deck"> </h3> <p class="main-subtitle"> </p> <div class="social-links-top"> <ul class="share"> <li class="l1"><a href="javascript:void(0)" class="facebook-link" target="_new">Facebook</a></li> <li class="l2"><a href="javascript:void(0)" class="twitter-link" target="_new">Tweet</a></li> <li class="l3"><a href="javascript:void(0)" class="linkedin-link">Share</a></li> </ul> </div> <ul class="meta-info"> <li> Ocular Surgery News U.S. Edition, January 10, 2013</li> </ul> <div class="wyContent"> <p class="Bodytext1">NEW YORK &mdash; An aspirin regimen should be considered a reasonable adjunctive treatment for <a href="https://web.archive.org/web/20130903024750/http://www.healio.com/ophthalmology/search.aspx?q=%22giant+cell+arteritis%22&amp;requiredfields=specialty:Ophthalmology&amp;client=healio_frontend&amp;output=xml_no_dtd&amp;proxystylesheet=healio_frontendCME&amp;site=healio-production&amp;lr=lang_en&amp;filter=p&amp;getfields=*&amp;ie=UTF-8&amp;ip=192.168.100.144&amp;access=p&amp;entqr=3&amp;oe=UTF-8&amp;ud=1&amp;sort=date%3AD%3AS%3Ad1" target="_blank">giant cell arteritis</a>, according to a speaker here.</p> <p class="Bodytext">According to <b>Michael S. Lee, MD,</b> speaking at <a href="https://web.archive.org/web/20130903024750/http://www.healio.com/ophthalmology/meetings/meeting-news-coverage?setid={A674D394-E846-4A5D-916D-E0EA07FE3209}" target="_blank">OSN New York 2012</a>, diagnosis of giant cell arteritis (GCA) is difficult because one in five patients with GCA has no symptoms or a normal erythrocyte sedimentation rate.</p> <p class="Bodytext">The level of C-reactive protein also creates a problem with GCA diagnosis, he said, because no standardized protocol has been created to address how these levels should be reported to physicians; different laboratories report C-reactive protein levels using different units, Lee said.</p> <p class="Bodytext">Temporal artery biopsy remains the diagnosis standard, and physicians should obtain at least 2 cm of temporal artery during the biopsy, according to Lee.</p> <p class="Bodytext">&ldquo;Rather than simultaneous biopsy, I personally fall on the side of biopsy one side first,&rdquo; he said. &ldquo;If it is positive, then stop. If it is negative, then consider biopsy the other side.&rdquo;</p> <p class="Bodytext">Although a consensus exists that steroids are the standard of treatment for GCA management, Lee said a lack of consensus remains on the dose, route and taper amounts. He said rheumatologists tend to prescribe lower steroid doses while ophthalmologists tend to prescribe higher amounts.</p> <p class="Bodytext">Intravenous&nbsp;methylprednisolone, oral steroids and methotrexate may also be beneficial treatments for patients with GCA, Lee said.</p> <p class="Bodytext">Reporting results from a retrospective study that examined ischemic events among GCA patients treated with aspirin, Lee said 16% of aspirin-treated patients reported an ischemic event, while 48% of non-aspirin-treated patients reported an ischemic event.</p> <p class="disclosure"><strong>Disclosure</strong>: Lee has no relevant financial disclosures.</p> <p class="disclosure">&nbsp;</p> <p><em>OSN New York 2013 will be held September 6-8 at the Waldorf-Astoria in New York City. 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