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The multi-scale causality of human cancer: An obstacle in the cli | 962
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This phenotypical variability is what primarily determines the..962"/> <meta name="citation_publisher" content="Longdom Publishing SL"/> <meta name="citation_journal_title" content="Translational Medicine"> <meta name="citation_title" content="The multi-scale causality of human cancer: An obstacle in the clinical practice"> <meta name="citation_online_date" content="0000/00/00" /> <meta name="citation_author" content="Fabio Grizzi"/> <meta name="citation_abstract_html_url" content="https://www.longdom.org/proceedings/the-multiscale-causality-of-human-cancer-an-obstacle-in-the-clinical-practice-962.html"/> <meta name="citation_pdf_url" content="https://www.longdom.org/conference-abstracts-files/2161-1025-S1.008-022.pdf"/> <meta name="citation_doi" content="10.4172/2161-1025.S1.008"/> </head> <body> <header> <!--=======top Navbar==========--> <nav class="navbar navbar-expand-lg navbar-light bg-white shadow-sm deva541"> <div class="container"> <a class="navbar-brand" 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class="mt-2"><i class="fas fa-user"></i> Fabio Grizzi</p> <p> </p> <p> </p> <p><strong>Scientific Tracks Abstracts</strong>: <a href="https://www.longdom.org/translational-medicine.html" title="click here">Transl Med</a></p> <h5 class="mt-0 mb-0 font-size-4 text-primary"><strong>Abstract </strong>:</h5> <p>Cancer is a heterogeneous disease: more than 100 types of human cancer have been described. This phenotypical variability is what primarily determines the self-progression of neoplasia and its response to therapy. Variability in cell response has important clinical implications. It is now known that in a heterogeneous population, patients may display a multiplicity of genetic variations that respond differently to a given medical intervention. The same treatment could be of benefit to some patients yet harmful to others. Human carcinogenesis is a dynamical process that depends on a large number of variables and is regulated at multiple spatial and temporal scales and whose behavior does not follow clearly predictable and repeatable pathways. This multiple scale causality not only recognizes multiple processes and controls acting at multiple scales. In other words, the observed phenomenon at each scale has structural and behavioral properties that do not exist at lower or higher organizational levels. To understand human cancer as a complex system we need to determine the type of data that needs to be collected at each level of organization, the boundary conditions to use when describing the disease, and the technologies and approaches best suited to reveal its underlying biological behavior. This ?quantitative? way of thinking that unites physicians, biologists, mathematicians and epidemiologists, may help to discover new biomarkers with potential clinical value.</p> <h5 class="mt-0 mb-0 font-size-4 text-primary"><strong>Biography </strong>:</h5> <p>Fabio Grizzi graduated in Biological Sciences from the University of Milan in 1995 and, in the same year, received the Steven Newburgh Annual Award for his contributions to the field of basic and applied biomedical research. In 2008, he was invited to become a member of the National Cancer Institute-sponsored Pilot Cancer Antigen Prioritization Process, of the US National Institute of Health. He is currently working in the Laboratory of Molecular Gastroenterology of the Humanitas Clinical and Research Center, Milan, Italy. He has published more than one hundred peer-reviewed articles, twenty-three book chapters, and has recently been commissioned by Springer Publishing to prepare a book entitled ?The Complexity of Cancer?.</p> <div class="btn-group"> <a href="https://www.longdom.org/conference-abstracts-files/2161-1025-S1.008-022.pdf" title="PDF" class="btn btn-sm btn-outline-primary"><i class="fa fa-file-pdf-o" aria-hidden="true"></i> PDF</a> <a href="https://www.longdom.org/proceedings/the-multiscale-causality-of-human-cancer-an-obstacle-in-the-clinical-practice-962.html" title="HTML" class="btn btn-sm btn-outline-primary"><i class="fa fa-file-code-o" aria-hidden="true"></i> HTML</a> <!--<a href="" title="Digital File" class="btn btn-sm btn-outline-primary"><i class="fa fa-microchip" aria-hidden="true"></i> Digital File</a>--> </div> </div> </div> </div> </section> <footer class="bg-blue-grey-900 py-3"> <div class="container"> <div class="row"> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Content Links</h4> <ul class="list-unstyled footer-links font-size-3"> <li><a class="" href="https://www.longdom.org/online-tools.html" title="Click here">Tools</a> </li> <li><a class="" href="https://www.longdom.org/feedback.html" title="Click here">Feedback</a></li> <li><a class="" href="https://www.longdom.org/careers.html" title="Click here">Careers</a></li> <li><a class="" href="https://www.longdom.org/privacy-policy.html" title="Click here">Privacy Policy</a></li> <li><a class="" href="https://www.longdom.org/terms-conditions.html" title="Click here">Terms & Conditions</a></li> <li><a class="" href="https://www.longdom.org/authors-reviewers-editors.html" title="Click here">Authors, Reviewers & Editors</a></li> </ul> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Contact Longdom</h4> <p>Longdom Group SA<br> Avenue Roger Vandendriessche,<br> 18, 1150 Brussels, Belgium<br> Phone: +442038085340 <br><strong>Email:</strong> <a href="mailto:info@longdom.org" class="white" title="Click here">info@longdom.org</a></p> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Connect</h4> <nav class="nav nav-pills social-icons-footer flex-column a-pl-0"> <a href="https://www.facebook.com/longdompublisher" title="Click here" target="_blank" class="nav-link bg-facebook-hover"><i class="fab fa-facebook-f bg-facebook"></i> Facebook</a> <a href="https://www.linkedin.com/company/longdom-publishing-sl/" title="Click here" target="_blank" class="nav-link bg-linkedin-hover"><i class="fab fa-linkedin-in bg-linkedin"></i> Linkedin</a> <a href="https://twitter.com/LongdomP" title="Click here" target="_blank" class="nav-link bg-twitter-hover"><i class="fab fa-twitter bg-twitter"></i> Twitter</a> <a href="https://www.instagram.com/longdom_publisher/" title="Click here" target="_blank" class="nav-link bg-instagram-hover"><i class="fab fa-instagram bg-instagram"></i> Instagram</a> </nav> </div> </div> <div class="row text-center"> <div class="col"> <p>Copyright © 2024 <a href="https://www.longdom.org/" title="Click here" class="white">Longdom Publishing</a>.</p> </div> </div> </div> </footer> <!--========================== Scroll To Top ============================--> <a href="#0" class="cd-top js-cd-top">Top</a> <!-- Optional JavaScript --> <!-- jQuery first, then Popper.js, then Bootstrap JS --> <script defer src="https://code.jquery.com/jquery-3.3.1.min.js"></script> <script defer src="https://cdnjs.cloudflare.com/ajax/libs/popper.js/1.14.7/umd/popper.min.js"></script> <script defer src="https://stackpath.bootstrapcdn.com/bootstrap/4.3.1/js/bootstrap.min.js"></script> <!--Get the app icon js--> <script> jQuery(function($) { $(window).scroll(function fix_element() { $('#target').css( $(window).scrollTop() > 100 ? 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