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<!DOCTYPE html> <html > <head> <meta charset="utf-8"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <meta content="width=device-width, initial-scale=1" name="viewport"> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs"> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="E78l6d6LeWTCZBxc80dcvxZr9NEhWJbXRXvLaVwbT26TTIEokbtL1y6ZlVmTsSQnoEEtFAWOTV4ZHGLMVVgUOQ" /> <meta name="citation_title" content="Risk management among benzene-exposed oil refinery workers" /> <meta name="citation_publication_date" content="2005/01/01" /> <meta name="citation_journal_title" content="International Journal of Hygiene and Environmental Health" /> <meta name="citation_author" content="غربه الحسن" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:url" content="https://www.academia.edu/3167331/Risk_management_among_benzene_exposed_oil_refinery_workers" /> <meta name="twitter:title" content="Risk management among benzene-exposed oil refinery workers" /> <meta name="twitter:description" content="Ten benzene-exposed oil refinery workers were genotoxicologically monitored in an annual follow-up study between 1990 and 2003 and compared with 87 industrial and 26 matched controls. 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Each of the exposed subjects suffered from several intercurrent" /> <title>(PDF) Risk management among benzene-exposed oil refinery workers</title> <link rel="canonical" href="https://www.academia.edu/3167331/Risk_management_among_benzene_exposed_oil_refinery_workers" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = 'dc2ad41da5d7ea682babd20f90650302fb0a3a36'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1739726578000); window.Aedu.timeDifference = new Date().getTime() - 1739726578000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"Ten benzene-exposed oil refinery workers were genotoxicologically monitored in an annual follow-up study between 1990 and 2003 and compared with 87 industrial and 26 matched controls. Each of the exposed subjects suffered from several intercurrent non-infectious diseases such as joint, rheumatic, gastric and dental problems, as well as kidney and liver dysfunctions. The structural chromosome aberration (CA) yields of the exposed donors suggested a dose-dependent response to the mean peak benzene concentrations in the ambient air. Sister chromatid exchange (SCE), high-frequency SCE, DNA repair, and cell proliferation data also indicated the presence of genotoxic exposure at the workplace. The results of the biological and genotoxicological monitoring indicated the need of intervention (primary prevention of occupational exposure-related chronic non-infectious diseases) including the introduction of zero tolerance of benzene emission, health control, and education with motivation to change life-styles. The decrease in CA frequencies considered as the most established genotoxicological effect markers indicated the positive changes due to the achieved zero tolerance at the workplaces. The results also demonstrated the effectiveness of a trilateral co-operation between the health services, the employer and the employee in order to reduce the risk of the exposure-related intercurrent non-infectious diseases and to prevent further deterioration of the health state of the workers.","author":[{"@context":"https://schema.org","@type":"Person","name":"غربه الحسن","url":"https://independent.academia.edu/%D8%BA%D8%B1%D8%A8%D9%87%D8%A7%D9%84%D8%AD%D8%B3%D9%86"}],"contributor":[],"dateCreated":"2013-03-30","dateModified":"2014-04-23","datePublished":"2005-01-01","headline":"Risk management among benzene-exposed oil refinery workers","image":"https://attachments.academia-assets.com/50428329/thumbnails/1.jpg","inLanguage":"en","keywords":[],"publication":"International Journal of Hygiene and Environmental 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{"work":{"id":3167331,"created_at":"2013-03-30T16:30:59.010-07:00","from_world_paper_id":117367954,"updated_at":"2021-01-14T04:57:42.162-08:00","_data":{"abstract":"Ten benzene-exposed oil refinery workers were genotoxicologically monitored in an annual follow-up study between 1990 and 2003 and compared with 87 industrial and 26 matched controls. Each of the exposed subjects suffered from several intercurrent non-infectious diseases such as joint, rheumatic, gastric and dental problems, as well as kidney and liver dysfunctions. The structural chromosome aberration (CA) yields of the exposed donors suggested a dose-dependent response to the mean peak benzene concentrations in the ambient air. Sister chromatid exchange (SCE), high-frequency SCE, DNA repair, and cell proliferation data also indicated the presence of genotoxic exposure at the workplace. The results of the biological and genotoxicological monitoring indicated the need of intervention (primary prevention of occupational exposure-related chronic non-infectious diseases) including the introduction of zero tolerance of benzene emission, health control, and education with motivation to change life-styles. The decrease in CA frequencies considered as the most established genotoxicological effect markers indicated the positive changes due to the achieved zero tolerance at the workplaces. The results also demonstrated the effectiveness of a trilateral co-operation between the health services, the employer and the employee in order to reduce the risk of the exposure-related intercurrent non-infectious diseases and to prevent further deterioration of the health state of the workers.","publication_date":"2005,,","publication_name":"International Journal of Hygiene and Environmental Health"},"document_type":"paper","pre_hit_view_count_baseline":0,"quality":"high","language":"en","title":"Risk management among benzene-exposed oil refinery workers","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [3617005]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loginModal = {}; window.loginModal.appleClientId = 'edu.academia.applesignon'; window.userInChina = "false";</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card ds-work-card--no-bottom-spacing"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":50428329,"attachmentType":"pdf"}"><img alt="First page of “Risk management among benzene-exposed oil refinery workers”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/50428329/mini_magick20190129-23057-1r7pw2e.png?1548765219" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/images/single_work_splash/adobe_icon.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Risk management among benzene-exposed oil refinery workers</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="3617005" href="https://independent.academia.edu/%D8%BA%D8%B1%D8%A8%D9%87%D8%A7%D9%84%D8%AD%D8%B3%D9%86"><img alt="Profile image of غربه الحسن" class="ds-work-card--author-avatar" src="https://0.academia-photos.com/3617005/1265529/1577101/s65__._.jpg" />غربه الحسن</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">2005, International Journal of Hygiene and Environmental Health</p><div class="ds-work-card--work-metadata"><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">visibility</span><p class="ds2-5-body-sm" id="work-metadata-view-count">…</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">description</span><p class="ds2-5-body-sm">8 pages</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">link</span><p class="ds2-5-body-sm">1 file</p></div></div><script>(async () => { const workId = 3167331; 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if (!viewCountBody) { throw new Error('Failed to find work views element'); } viewCountBody.textContent = `${commaizedViewCount} views`; } catch (error) { // Remove the whole views element if there was some issue parsing. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); throw new Error(`Failed to parse view count: ${viewCount}`, error); } }; // If the DOM is still loading, wait for it to be ready before updating the view count. if (document.readyState === "loading") { document.addEventListener('DOMContentLoaded', () => { updateViewCount(viewCount); }); // Otherwise, just update it immediately. } else { updateViewCount(viewCount); } })();</script></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">Ten benzene-exposed oil refinery workers were genotoxicologically monitored in an annual follow-up study between 1990 and 2003 and compared with 87 industrial and 26 matched controls. Each of the exposed subjects suffered from several intercurrent non-infectious diseases such as joint, rheumatic, gastric and dental problems, as well as kidney and liver dysfunctions. The structural chromosome aberration (CA) yields of the exposed donors suggested a dose-dependent response to the mean peak benzene concentrations in the ambient air. Sister chromatid exchange (SCE), high-frequency SCE, DNA repair, and cell proliferation data also indicated the presence of genotoxic exposure at the workplace. The results of the biological and genotoxicological monitoring indicated the need of intervention (primary prevention of occupational exposure-related chronic non-infectious diseases) including the introduction of zero tolerance of benzene emission, health control, and education with motivation to change life-styles. The decrease in CA frequencies considered as the most established genotoxicological effect markers indicated the positive changes due to the achieved zero tolerance at the workplaces. The results also demonstrated the effectiveness of a trilateral co-operation between the health services, the employer and the employee in order to reduce the risk of the exposure-related intercurrent non-infectious diseases and to prevent further deterioration of the health state of the workers.</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":50428329,"attachmentType":"pdf","workUrl":"https://www.academia.edu/3167331/Risk_management_among_benzene_exposed_oil_refinery_workers"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":50428329,"attachmentType":"pdf","workUrl":"https://www.academia.edu/3167331/Risk_management_among_benzene_exposed_oil_refinery_workers"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div><div class="ds-signup-banner-trigger-container"><div class="ds-signup-banner-trigger ds-signup-banner-trigger-control"></div></div><div class="ds-signup-banner ds-signup-banner-control"><div id="ds-signup-banner-close-button"><button class="ds2-5-button ds2-5-button--secondary ds2-5-button--inverse"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">close</span></button></div><div class="ds-signup-banner-ctas"><img src="//a.academia-assets.com/images/academia-logo-capital-white.svg" /><h4 class="ds2-5-heading-serif-sm">Sign up for access to the world's latest research</h4><button class="ds2-5-button ds2-5-button--inverse ds2-5-button--full-width js-swp-download-button" data-signup-modal="{"location":"signup-banner"}">Sign up for free<span class="material-symbols-outlined" style="font-size: 20px" translate="no">arrow_forward</span></button></div><div class="ds-signup-banner-divider"></div><div class="ds-signup-banner-reasons"><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Get notified about relevant papers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Save papers to use in your research</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Join the discussion with peers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Track your impact</span></div></div></div><script>(() => { // Set up signup banner show/hide behavior: // 1. 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data-author-id="37861759" href="https://independent.academia.edu/SKang4">S. Kang</a><span>, </span><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="39303370" href="https://independent.academia.edu/HyungsikKang">Hyung-sik Kang</a><span>, </span><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37753021" href="https://independent.academia.edu/DonggeunSul">Donggeun Sul</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2005</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"DNA damage in lymphocytes of benzene exposed workers correlates with trans,trans-muconic acids and breath benzene 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class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/55509245/Interphase_cytogenetics_of_workers_exposed_to_benzene">Interphase cytogenetics of workers exposed to benzene</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="66419086" href="https://independent.academia.edu/ZhangLuoping">Luoping Zhang</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Environmental Health Perspectives, 1996</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Interphase cytogenetics of workers exposed to benzene","attachmentId":71346584,"attachmentType":"pdf","work_url":"https://www.academia.edu/55509245/Interphase_cytogenetics_of_workers_exposed_to_benzene","alternativeTracking":true}"><span 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ds2-5-body-sm ds2-5-body-link" data-author-id="1020414" href="https://independent.academia.edu/AlexanderDecker">Alexander Decker</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"11.Chromosomal Damage Risk Assessment to Benzene Exposure","attachmentId":13096431,"attachmentType":"pdf","work_url":"https://www.academia.edu/1545014/11_Chromosomal_Damage_Risk_Assessment_to_Benzene_Exposure","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/1545014/11_Chromosomal_Damage_Risk_Assessment_to_Benzene_Exposure"><span class="ds2-5-text-link__content">View PDF</span><span 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Maffei</a><span>, </span><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="31240221" href="https://unibo.academia.edu/PatriziaHrelia">Patrizia Hrelia</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2014</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Evaluation of chromosome aberration and micronucleus frequencies in blood lymphocytes of workers exposed to low concentrations of benzene","attachmentId":46185577,"attachmentType":"pdf","work_url":"https://www.academia.edu/12434962/Evaluation_of_chromosome_aberration_and_micronucleus_frequencies_in_blood_lymphocytes_of_workers_exposed_to_low_concentrations_of_benzene","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" 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attendants</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37460995" href="https://independent.academia.edu/CaterinaTanzarella">Caterina Tanzarella</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1995</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Genetic effects of petroleum fuels: cytogenetic monitoring of gasoline station attendants","attachmentId":103236335,"attachmentType":"pdf","work_url":"https://www.academia.edu/103154062/Genetic_effects_of_petroleum_fuels_cytogenetic_monitoring_of_gasoline_station_attendants","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span 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ds2-5-body-link" data-author-id="46107781" href="https://independent.academia.edu/ParamjitGrover">Paramjit Grover</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Annals of Occupational Hygiene, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Genotoxicity in Filling Station Attendants Exposed to Petroleum Hydrocarbons","attachmentId":110697631,"attachmentType":"pdf","work_url":"https://www.academia.edu/113840062/Genotoxicity_in_Filling_Station_Attendants_Exposed_to_Petroleum_Hydrocarbons","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/113840062/Genotoxicity_in_Filling_Station_Attendants_Exposed_to_Petroleum_Hydrocarbons"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="14" data-entity-id="18474095" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/18474095/An_Epidemiologic_Study_of_Early_Biologic_Effects_of_Benzene_in_Chinese_Workers">An Epidemiologic Study of Early Biologic Effects of Benzene in Chinese Workers</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="38486006" href="https://independent.academia.edu/JosephWiemels">Joseph Wiemels</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Environmental Health Perspectives, 1996</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"An Epidemiologic Study of Early Biologic Effects of Benzene in Chinese Workers","attachmentId":40082461,"attachmentType":"pdf","work_url":"https://www.academia.edu/18474095/An_Epidemiologic_Study_of_Early_Biologic_Effects_of_Benzene_in_Chinese_Workers","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/18474095/An_Epidemiologic_Study_of_Early_Biologic_Effects_of_Benzene_in_Chinese_Workers"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" 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href="https://www.academia.edu/87258038/No_increase_in_chromosome_aberrations_in_workers_from_an_oil_catalytic_cracking_plant">No increase in chromosome aberrations in workers from an oil catalytic cracking plant</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="50981303" href="https://independent.academia.edu/ArmandoRojas16">Armando Rojas</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Mutation Research Letters, 1992</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"No increase in chromosome aberrations in workers from an oil catalytic cracking plant","attachmentId":91518453,"attachmentType":"pdf","work_url":"https://www.academia.edu/87258038/No_increase_in_chromosome_aberrations_in_workers_from_an_oil_catalytic_cracking_plant","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/87258038/No_increase_in_chromosome_aberrations_in_workers_from_an_oil_catalytic_cracking_plant"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="17" data-entity-id="13405295" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md 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