RDIT® De-immunization Services

<!DOCTYPE html> <html lang="en-us"> <head><meta http-equiv="Content-Type" content="text/html; charset=utf-8" /><meta charset="utf-8" /><meta http-equiv="X-UA-Compatible" content="IE=edge" /><meta name="viewport" content="width=device-width, initial-scale=1" /><title> RDIT® De-immunization Services - Creative Biolabs </title> <base href="/" /> <link rel="icon" href="static/images/favicon.png" type="image/x-icon" />  <link rel="stylesheet" type="text/css" href="static/css/key.css?t=D20190703" /><link rel="preconnect" href="https://www.googletagmanager.com" /><link rel="preconnect" href="https://bat.bing.com" /><link rel="preconnect" href="https://www.cblcdn.com" /><link rel="canonical" href="https://www.creative-biolabs.com/De-immunogenicity-De-immunization.html" /> <link rel="stylesheet" type="text/css" href="static/css/style-services.min.css?t=D20190703" /> <link rel="stylesheet" type="text/css" href="static/css/style-podcast.min.css?t=D20190703" /> <link rel="stylesheet" type="text/css" href="static/css/style-inquiry.min.css?t=D20190703" /> <style> .inquiry_arera { padding-top: 30px; padding-bottom: 30px; background-color: #f2f2f2; display: block; } .inquiry_arera div[class*="col"] { padding-top: 5px; padding-bottom: 5px; } span.inq-icon-but { background: linear-gradient(to right, #c45160,#f0924c ) !important; color: #fff; text-align: center; font-weight: bold; padding:7px 50px 7px 10px; display: inline-block; cursor: pointer; position: relative; } span.inq-icon-but::after{ content:""; position: absolute; background-image: url('../static/images/5-120601154058-50.gif'); top:6px; right:10px; width:30px; height:30px; background-repeat: no-repeat; background-position: center; } .inqpagebut span.inq-icon-but::after{ content:"→" !important; background-image:none !important; top:8px !important; font-size:20px; } .inqpagebut{display: block;padding-top:30px !important;padding-bottom:30px !important; text-align: center;} span.inq-icon-but:hover { background-color: linear-gradient(to right, #f0924c,#c45160 ) !important; color: #fff; } .inq_bg { position: fixed; top: 0px; left: 0; background-color: rgba(0,0,0,0.7); width: 100%; height: 100%; z-index: 1100; align-items: center; justify-content: center; display: none; } .inq_bg .inqfor { background-color: #fff; padding: 20px; border-radius: 10px; position: relative; margin: 4% auto auto auto; } .inq_bg .inqfor .clos { width: 40px; height: 40px; top: 0; right: 0px; position: absolute; display: inline-block; line-height: 40px; text-align: center; font-size: 24px; z-index: 1000; cursor: pointer; } @media (min-width:769px) { .inq_bg .inqfor { width: 60%; } .inqfor div[class*="col-md"]:nth-child(1),.inqfor div[class*="col-md"]:nth-child(2),.inqfor div[class*="col-md"]:nth-child(3){ width:33.3% !important; } } @media (max-width:768px) { .inq_bg .inqfor { width: 90%; overflow-y: scroll; } } </style> <script>dataLayer = [{"ip":"8.222.208.146","c_session_id":"908A6F93632807189F807A7AD9AD99F2","c_user_id":"908A6F93632807189F807A7AD9AD99F2"}];</script>  <script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-MD8987');</script> <meta name="description" content="Creative Biolabs provides RDIT® de-immunization services for a collection of biotherapeutic drugs." /><meta name="keywords" content="de-immunization, de-immunogenicity, immunogenicity, decrease immunogenicity, lower antigenicity, lower immunogenicity, T cell epitope removal, Anti-drug antibody" /></head> <body>  <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-MD8987&ip=8.222.208.146&c_session_id=908A6F93632807189F807A7AD9AD99F2&c_user_id=908A6F93632807189F807A7AD9AD99F2" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>  <div class="autoheader"> <div class="topad_pic" style="display: block;">  <a href="https://events.creative-biolabs.com" id="ad_exhibition" rel="nofollow" aria-label="Meet Us at the Upcoming Events"> <div class="source-img-box"> </div> </a> </div> <div id="header"> <a href="/"> <img src="static/images/biolabs.com-1921x690-color.png" srcset="static/images/biolabs.com-1921x690-color.webp 1x, static/images/biolabs.com-1921x690-color.webp 2x, static/images/biolabs.com-1921x690-color.webp 3x" id="logo" width="120" height="60" alt="Creative biolabs"></a> <div class="navMenu"> <span><i class="fa fa-bars"></i>MENU</span> <span><i class="fa fa-search"></i>SEARCH</span> </div> </div> </div> <div class="nav_bg" style="background-color: rgba(0,0,0,0.6);"></div> <div class="menuShow"> <span class="menuclosed"><i class="fa fa-times"></i>Close</span> <div class="mennav"> <ul style="position: relative;"> <li> <span>Discovery</span> <div class="secondMenu"> <div class="second-menu-area-box"> <ul style="margin-top:0;">  <li class="col-md-8 col-lg-8 col-sm-8"> <ul class="navi-menu-2 MenuList"><li class="navi-menu-li-2 col-md-4 col-lg-4 col-sm-4"><a href="javascript:void(0)" title="By Technology">By Technology</a><ul class="navi-menu-3 three_menu"><li class="navi-menu-li-3"><a href="/phage-display-service.html" title="Phage Display based Binder Discovery">Phage Display based Binder Discovery</a><ul class="navi-menu-4 three_menu"><li class="navi-menu-li-4"><a href="/phage-display-library-construction.html" title="Phage Display Library Construction">Phage Display Library Construction</a></li><li class="navi-menu-li-4"><a href="/phage-display-library-screening.html" title="Phage Display Library Screening">Phage Display Library Screening</a></li></ul></li><li class="navi-menu-li-3"><a href="/yeast-display-services.html" title="Yeast Display based Binder Discovery">Yeast Display based Binder Discovery</a><ul class="navi-menu-4 three_menu"><li class="navi-menu-li-4"><a href="/yeast-display-library-construction-services.html" title="Yeast Display Library Construction">Yeast Display Library Construction</a></li><li class="navi-menu-li-4"><a href="/yeast-display-library-screening-services.html" title="Yeast Display Library Screening">Yeast Display Library Screening</a></li></ul></li><li class="navi-menu-li-3"><a href="/premade-library-based-binder-discovery-services.html" title="Premade Library based Binder Discovery">Premade Library based Binder Discovery</a><ul class="navi-menu-4 three_menu"><li class="navi-menu-li-4"><a href="javascript:void(0)" title="Premade Library Licensing">Premade Library Licensing</a><ul class="navi-menu-5 three_menu"><li class="navi-menu-li-5"><a href="/premade-human-and-mouse-antibody-libraries.html" title="Premade Antibody Library">Premade Antibody Library</a></li><li class="navi-menu-li-5"><a href="/premade-phage-display-peptide-libraries.html" title="Premade Peptide Library">Premade Peptide Library</a></li><li class="navi-menu-li-5"><a href="/Premade-single-domain-antibody-library.html" title="Premade SdAb Library">Premade SdAb Library</a></li><li class="navi-menu-li-5"><a href="/Immunized-Human-Antibody-Library.html" title="Immune Human Antibody Library">Immune Human Antibody Library</a></li></ul></li><li class="navi-menu-li-4"><a href="/premade-phage-display-antibody-library-screening-service.html" title="Premade Antibody Library Screening">Premade Antibody Library Screening</a></li><li class="navi-menu-li-4"><a href="/premade-single-domain-antibody-library-screening-service.html" title="Premade Single Domain Antibody (SdAb) Library Screening">Premade Single Domain Antibody (SdAb) Library Screening</a></li><li class="navi-menu-li-4"><a href="/premade-phage-display-peptide-library-screening-service.html" title="Premade Peptide Library Screening">Premade Peptide Library Screening</a></li></ul></li><li class="navi-menu-li-3"><a href="/Native-TM-Antibody-Discovery-Service.html" title="Single B Cell Sorting based Antibody Discovery">Single B Cell Sorting based Antibody Discovery</a></li><li class="navi-menu-li-3"><a href="/custom-antibody-development.html" title="Hybridoma based Antibody Discovery">Hybridoma based Antibody Discovery</a></li><li class="navi-menu-li-3"><a href="/Human-Antibody-Production-from-Transgenic-Mice.html" title="Transgenic Mice based Human Antibody Discovery">Transgenic Mice based Human Antibody Discovery</a></li><li class="navi-menu-li-3"><a href="/biomolecular-interaction-analysis-services.html" title="Biomolecular Interaction based Binder Discovery">Biomolecular Interaction based Binder Discovery</a><ul class="navi-menu-4 three_menu"><li class="navi-menu-li-4"><a href="/yeast-two-hybrid-y2h-service.html" title="Yeast Two-Hybrid (Y2H)">Yeast Two-Hybrid (Y2H)</a></li><li class="navi-menu-li-4"><a href="/bacterial-two-hybrid-b2h-service.html" title="Bacterial Two-Hybrid (B2H)">Bacterial Two-Hybrid (B2H)</a></li></ul></li></ul></li><li class="navi-menu-li-2 col-md-4 col-lg-4 col-sm-4"><a href="javascript:void(0)" title="By Binder">By Binder</a><ul class="navi-menu-3 three_menu"><li class="navi-menu-li-3"><a href="/sdab-single-domain-antibody.html" title="Single Domain Antibody (SdAb) Discovery">Single Domain Antibody (SdAb) Discovery</a><ul class="navi-menu-4 three_menu"><li class="navi-menu-li-4"><a href="/single-domain-antibody-library-service.html" title="SdAb Library Construction & Screening">SdAb Library Construction & Screening</a></li><li class="navi-menu-li-4"><a href="/human-or-humanized-sdab-production.html" title="Human/Humanized SdAb Discovery">Human/Humanized SdAb Discovery</a></li><li class="navi-menu-li-4"><a href="/bispecific-sdab-production.html" title="Bispecific SdAb Discovery">Bispecific SdAb Discovery</a></li></ul></li><li class="navi-menu-li-3"><a href="/immune-antibody-library-services.html" title="Monoclonal Antibody Discovery">Monoclonal Antibody Discovery</a></li><li class="navi-menu-li-3"><a href="/discovery-services.html" title="Polyclonal Antibody Discovery">Polyclonal Antibody Discovery</a></li><li class="navi-menu-li-3"><a href="/Engineered-Protein-Scaffold-Library-Construction-Service.html" title="Scaffold Discovery">Scaffold Discovery</a></li><li class="navi-menu-li-3"><a href="/Magic-Bioactive-Peptides-Discovery-Service.htm" title="Peptide Discovery">Peptide Discovery</a></li></ul></li><li class="navi-menu-li-2 col-md-4 col-lg-4 col-sm-4"><a href="javascript:void(0)" title="By Target">By Target</a><ul class="navi-menu-3 three_menu"><li class="navi-menu-li-3"><a href="/membrane-protein-service.html" title="Membrane Protein Specific Antibody Discovery">Membrane Protein Specific Antibody Discovery</a><ul class="navi-menu-4 three_menu"><li class="navi-menu-li-4"><a href="/membrane-protein-preparation-as-antigen-for-antibody-discovery.html" title="Membrane Protein Antigen Preparation">Membrane Protein Antigen Preparation</a></li><li class="navi-menu-li-4"><a href="/MemProArt-TM-anti-GPCR-Antibody-Production.html" title="GPCR Specific Antibody Discovery">GPCR Specific Antibody Discovery</a></li><li class="navi-menu-li-4"><a href="/MemProArt-TM-anti-Ion-Channel-Antibody-Production.html" title="Ion Channel Specific Antibody Discovery">Ion Channel Specific Antibody Discovery</a></li><li class="navi-menu-li-4"><a href="/MemProArt-TM-anti-transporter-Antibody-Production.html" title="Transporter Specific Antibody Discovery">Transporter Specific Antibody Discovery</a></li><li class="navi-menu-li-4"><a href="/sdab-discovery-against-membrane-proteins-by-dna-immunization.html" title="Membrane Protein Specific Single Domain Antibody (SdAb) Discovery">Membrane Protein Specific Single Domain Antibody (SdAb) Discovery</a></li></ul></li><li class="navi-menu-li-3"><a href="/Custom-antibody-services-for-post-translational-modification-specific-antibody-discovery.html" title="Post-Translational Modification (PTM) Specific Antibody Discovery">Post-Translational Modification (PTM) Specific Antibody Discovery</a><ul class="navi-menu-4 three_menu"><li class="navi-menu-li-4"><a href="/Phosphorylation-Specific-Antibody-Production-Services.html" title="Phosphorylation Specific Antibody Discovery">Phosphorylation Specific Antibody Discovery</a></li><li class="navi-menu-li-4"><a href="/Acetylation-Specific-Antibody-Production-Services.html" title="Acetylation Specific Antibody Discovery">Acetylation Specific Antibody Discovery</a></li><li class="navi-menu-li-4"><a href="/Methylation-Specific-Antibody-Production-Services.html" title="Methylation Specific Antibody Discovery">Methylation Specific Antibody Discovery</a></li><li class="navi-menu-li-4"><a href="/Ubiquitination-Specific-Antibody-Production-Service.html" title="Ubiquitination Specific Antibody Discovery">Ubiquitination Specific Antibody Discovery</a></li><li class="navi-menu-li-4"><a href="/fatty-acylation-specific-antibody-production-services.html" title="Fatty Acylation (Myristoylation, Palmitoylation) Specific Antibody Discovery">Fatty Acylation (Myristoylation, Palmitoylation) Specific Antibody Discovery</a></li></ul></li><li class="navi-menu-li-3"><a href="/Production-of-Anti-idiotype-Antibody.html" title="Idiotype Specific Antibody Discovery">Idiotype Specific Antibody Discovery</a><ul class="navi-menu-4 three_menu"><li class="navi-menu-li-4"><a href="/Anti-Idiotypic-Antibodies-Production-service-detecting-FREE-antibodies.html" title="FREE Antibody recognized Anti-ID Antibody Discovery">FREE Antibody recognized Anti-ID Antibody Discovery</a></li><li class="navi-menu-li-4"><a href="/Anti-Idiotypic-Antibodies-Prodution-detecting-TOTAL-antibodiese.html" title="TOTAL Antibody recognized Anti-ID Antibody Discovery">TOTAL Antibody recognized Anti-ID Antibody Discovery</a></li><li class="navi-menu-li-4"><a href="/Anti-Idiotypic-Antibodies-Production-service-detecting-BOUND-antibodies.html" title="BOUND Antibody recognized Anti-ID Antibody Discovery">BOUND Antibody recognized Anti-ID Antibody Discovery</a></li><li class="navi-menu-li-4"><a href="/Anti-Idiotypic-Antibodies-Production-service-detecting-T-cell-receptors.html" title="T Cell Receptor recognized Anti-ID Antibody Discovery">T Cell Receptor recognized Anti-ID Antibody Discovery</a></li><li class="navi-menu-li-4"><a href="/camel-anti-idiotypic-antibodies-sdabs-production-service.html" title="Idiotype Specific Single Domain Antibody (SdAb) Discovery">Idiotype Specific Single Domain Antibody (SdAb) Discovery</a></li></ul></li><li class="navi-menu-li-3"><a href="/anti-hapten-antibody-development-service.html" title="Hapten Specific Antibody Discovery">Hapten Specific Antibody Discovery</a></li></ul></li><li class="navi-menu-li-2 col-md-4 col-lg-4 col-sm-4"><a href="javascript:void(0)" title="By Application">By Application</a><ul class="navi-menu-3 three_menu"><li class="navi-menu-li-3"><a href="javascript:void(0)" title="Stable Binder Discovery">Stable Binder Discovery</a><ul class="navi-menu-4 three_menu"><li class="navi-menu-li-4"><a href="/thermal-stable-mabs-discovery-services.html" title="Thermal Stable mAb Discovery">Thermal Stable mAb Discovery</a></li><li class="navi-menu-li-4"><a href="/Thermal-Stable-scFv-Fab-Screening.html" title="Thermal Stable ScFv/Fab Discovery">Thermal Stable ScFv/Fab Discovery</a></li><li class="navi-menu-li-4"><a href="/thermal-stable-vhh-screening.html" title="Thermal Stable SdAb Discovery">Thermal Stable SdAb Discovery</a></li></ul></li><li class="navi-menu-li-3"><a href="/ph-sensitive-biomolecules-discovery-services.html" title="pH-Sensitive Binder Discovery">pH-Sensitive Binder Discovery</a></li><li class="navi-menu-li-3"><a href="/Screening-for-Internalizing-Antibodies-and-Peptides.html" title="Internalizing Antibody Discovery">Internalizing Antibody Discovery</a></li><li class="navi-menu-li-3"><a href="/Super-TM-Intrabody-Generation.html" title="Intrabody Discovery">Intrabody Discovery</a><ul class="navi-menu-4 three_menu"><li class="navi-menu-li-4"><a href="/intrabody-discovery-service.html" title="SdAb based Intrabody Discovery">SdAb based Intrabody Discovery</a></li></ul></li><li class="navi-menu-li-3"><a href="/Agonistic-Antibody-Discovery-Service.html" title="Agonistic/Antagonistic Antibody Discovery">Agonistic/Antagonistic Antibody Discovery</a></li></ul></li></ul> </li> <li class="col-md-4 col-lg-4 col-sm-4"> <b class="Highlights_tit">Services</b> <p class="open-sans-light"> Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects. </p>  <b class="Highlights_tit">Highlights</b> <ul class="HighlightsArea"> <li class="col-md-6 col-lg-6 col-sm-6"> <img src="static/images/Solutions-menu-lights-pic-1.jpg" srcset="static/images/Solutions-menu-lights-pic-1.webp 1x" width="201" height="131" loading="lazy"><a href="discovery-services.html" class="bannerbutton"><i class="fa fa-angle-right"></i>Discovery Services</a> </li> <li class="col-md-6 col-lg-6 col-sm-6"> <img src="static/images/Solutions-menu-lights-pic-2.jpg" srcset="static/images/Solutions-menu-lights-pic-2.webp 1x" width="201" height="131" loading="lazy"><a href="engineering-services.html" class="bannerbutton"> <i class="fa fa-angle-right"></i>Engineering Services </a> </li> </ul> </li> </ul> </div> </div> </li> <li> <span>Characterization</span> <div class="secondMenu"> <div class="second-menu-area-box"> <ul style="margin-top:0;">  <li class="col-md-8 col-lg-8 col-sm-8"> <ul class="navi-menu-2 MenuList"><li class="navi-menu-li-2 col-md-4 col-lg-4 col-sm-4"><a href="javascript:void(0)" title="Binding Analysis">Binding Analysis</a><ul class="navi-menu-3 three_menu"><li class="navi-menu-li-3"><a href="/Antibody-Affinity-Measurement.html" title="Affinity Measurement">Affinity Measurement</a><ul class="navi-menu-4 three_menu"><li class="navi-menu-li-4"><a href="/Affinity-Measurement-Services-for-Specific-Antibodies.html" title="Antibody Affinity Measurement">Antibody Affinity Measurement</a></li><li class="navi-menu-li-4"><a href="/Membrane-Proteins-Affinity-Measurement.html" title="Membrane Protein Affinity Measurement">Membrane Protein Affinity Measurement</a></li><li class="navi-menu-li-4"><a href="/Affinity-Measurement-Services-for-Small-Molecules.html" title="Small Molecule Affinity Measurement">Small Molecule Affinity Measurement</a></li></ul></li><li class="navi-menu-li-3"><a href="/precision-paratope-mapping-service.htm" title="Paratope Mapping">Paratope Mapping</a></li><li class="navi-menu-li-3"><a href="/Monoclonal-Antibody-Epitope-Binning.html" title="Epitope Binning">Epitope Binning</a></li><li class="navi-menu-li-3"><a href="/cremap.html" title="Epitope Mapping">Epitope Mapping</a><ul class="navi-menu-4 three_menu"><li class="navi-menu-li-4"><a href="/cremap-b-cell-epitope-mapping-service.html" title="B Cell Epitope Mapping">B Cell Epitope Mapping</a></li><li class="navi-menu-li-4"><a href="/cremap-t-cell-epitope-discovery-service.html" title="T Cell Epitope Discovery">T Cell Epitope Discovery</a></li></ul></li><li class="navi-menu-li-3"><a href="/high-throughput-membrane-protein-array-screening-services.html" title="Antibody Off-Target Identification & Specificity Profiling">Antibody Off-Target Identification & Specificity Profiling</a></li></ul></li><li class="navi-menu-li-2 col-md-4 col-lg-4 col-sm-4"><a href="javascript:void(0)" title="Sequence Analysis">Sequence Analysis</a><ul class="navi-menu-3 three_menu"><li class="navi-menu-li-3"><a href="/next-generation-antibody-sequencing.html" title="<i>De Novo</i> Sequencing"><i>De Novo</i> Sequencing</a><ul class="navi-menu-4 three_menu"><li class="navi-menu-li-4"><a href="/De-Novo-Human-Humanized-Antibody-Sequencing-Service.html" title="Human/Humanized Antibody Sequencing">Human/Humanized Antibody Sequencing</a></li><li class="navi-menu-li-4"><a href="/De-Novo-Biosimilar-monoclonal-antibodies-Sequencing-Service.html" title="Biosimilar mAb Sequencing">Biosimilar mAb Sequencing</a></li><li class="navi-menu-li-4"><a href="/de-novo-sdab-sequencing-service.html" title="Single Domain Antibody (SdAb) Sequencing">Single Domain Antibody (SdAb) Sequencing</a></li><li class="navi-menu-li-4"><a href="/De-Novo-Rodent-Antibody-Sequencing-Service.html" title="Rodent Antibody Sequencing">Rodent Antibody Sequencing</a></li><li class="navi-menu-li-4"><a href="/De-Novo-Rabbit-Antibody-Sequencing-Service.html" title="Rabbit Antibody Sequencing">Rabbit Antibody Sequencing</a></li><li class="navi-menu-li-4"><a href="/De-Novo-Chicken-IgYs-Sequencing-Service.html" title="Chicken IgY Sequencing">Chicken IgY Sequencing</a></li><li class="navi-menu-li-4"><a href="/De-Novo-TCR-T-cell-Receptor-Sequencing-Service.html" title="T Cell Receptor (TCR) Sequencing">T Cell Receptor (TCR) Sequencing</a></li></ul></li><li class="navi-menu-li-3"><a href="/antibody-sequencing-service.html" title="Hybridoma Sequencing">Hybridoma Sequencing</a></li></ul></li><li class="navi-menu-li-2 col-md-4 col-lg-4 col-sm-4"><a href="/immunologic-analysis-services.html" title="Immunogenicity Analysis">Immunogenicity Analysis</a><ul class="navi-menu-3 three_menu"><li class="navi-menu-li-3"><a href="/SIAT.html" title="Immunogenicity Assessment">Immunogenicity Assessment</a><ul class="navi-menu-4 three_menu"><li class="navi-menu-li-4"><a href="/in-silico-Immunogenicity-Assessment.html" title="<i>In Silico</i> Assessment"><i>In Silico</i> Assessment</a></li><li class="navi-menu-li-4"><a href="/ex-vivo-Immunogenicity-Assessment.html" title="<i>Ex Vivo</i> Assessment"><i>Ex Vivo</i> Assessment</a></li><li class="navi-menu-li-4"><a href="/in-vivo-Immunogenicity-Assessment.html" title="<i>In Vivo</i> Assessment"><i>In Vivo</i> Assessment</a></li><li class="navi-menu-li-4"><a href="/Anti-drug-Antibodies-ADA-Assays.html" title="Anti-Drug Antibodies (ADA) Assay">Anti-Drug Antibodies (ADA) Assay</a></li></ul></li><li class="navi-menu-li-3"><a href="/Magic-Therapeutic-Antibody-Discovery-Service.htm" title="Repertoire Analysis">Repertoire Analysis</a><ul class="navi-menu-4 three_menu"><li class="navi-menu-li-4"><a href="/magic-bcr-repertoire-analysis.html" title="BCR Repertoire Analysis">BCR Repertoire Analysis</a></li><li class="navi-menu-li-4"><a href="/magic-tcr-repertoire-sequencing-service.html" title="TCR Repertoire Analysis">TCR Repertoire Analysis</a></li></ul></li><li class="navi-menu-li-3"><a href="/ecia.html" title="Cellular Analysis">Cellular Analysis</a><ul class="navi-menu-4 three_menu"><li class="navi-menu-li-4"><a href="/hla-tissue-typing.html" title="HLA Tissue Typing">HLA Tissue Typing</a></li><li class="navi-menu-li-4"><a href="/ecia-b-cell-elispot-assay.html" title="B Cell ELISpot">B Cell ELISpot</a></li><li class="navi-menu-li-4"><a href="/ecia-t-cell-elispot-assay.html" title="T Cell ELISpot">T Cell ELISpot</a></li></ul></li><li class="navi-menu-li-3"><a href="/De-immunogenicity-De-immunization.html" title="De-immunization">De-immunization</a></li></ul></li><li class="navi-menu-li-2 col-md-4 col-lg-4 col-sm-4"><a href="/Antibody-Analysis-Services.html" title="Property Analysis">Property Analysis</a><ul class="navi-menu-3 three_menu"><li class="navi-menu-li-3"><a href="/Isothermal-Titration-Calorimetry-ITC-Service.html" title="ITC Assessment">ITC Assessment</a></li><li class="navi-menu-li-3"><a href="/Differential-scanning-calorimetry-DSC-Service.html" title="DSC Assessment">DSC Assessment</a></li></ul></li><li class="navi-menu-li-2 col-md-4 col-lg-4 col-sm-4"><a href="/drug-discovery/therapeutics/antibody-function-assays.htm" title="Functional Analysis">Functional Analysis</a></li></ul> </li> <li class="col-md-4 col-lg-4 col-sm-4"> <b class="Highlights_tit">Services</b> <p class="open-sans-light"> Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects. </p>  <b class="Highlights_tit">Highlights</b> <ul class="HighlightsArea"> <li class="col-md-6 col-lg-6 col-sm-6"> <img src="static/images/Solutions-menu-lights-pic-1.jpg" srcset="static/images/Solutions-menu-lights-pic-1.webp 1x" width="201" height="131" loading="lazy"><a href="discovery-services.html" class="bannerbutton"><i class="fa fa-angle-right"></i>Discovery Services</a> </li> <li class="col-md-6 col-lg-6 col-sm-6"> <img src="static/images/Solutions-menu-lights-pic-2.jpg" srcset="static/images/Solutions-menu-lights-pic-2.webp 1x" width="201" height="131" loading="lazy"><a href="engineering-services.html" class="bannerbutton"> <i class="fa fa-angle-right"></i>Engineering Services </a> </li> </ul> </li> </ul> </div> </div> </li> <li> <span>Engineering</span> <div class="secondMenu"> <div class="second-menu-area-box"> <ul style="margin-top:0;">  <li class="col-md-8 col-lg-8 col-sm-8"> <ul class="navi-menu-2 MenuList"><li class="navi-menu-li-2 col-md-4 col-lg-4 col-sm-4"><a href="/Antibody-Engineering-Services.html" title="Antibody Conversion">Antibody Conversion</a><ul class="navi-menu-3 three_menu"><li class="navi-menu-li-3"><a href="/Human-or-Humanized-Antibody-Services.html" title="Humanization (Convert to Human Ab)">Humanization (Convert to Human Ab)</a></li><li class="navi-menu-li-3"><a href="/Antibody-Camelization-Services.html" title="Camelization (Convert to Single Domain Ab)">Camelization (Convert to Single Domain Ab)</a></li><li class="navi-menu-li-3"><a href="/Antibody-Caninization-Service.html" title="Caninization (Convert to Dog Ab)">Caninization (Convert to Dog Ab)</a></li><li class="navi-menu-li-3"><a href="/Simianization-of-Non-monkey-Antibodies.html" title="Simianization (Convert to NHP Ab)">Simianization (Convert to NHP Ab)</a></li><li class="navi-menu-li-3"><a href="/Antibody-Murinization-Service.html" title="Murinization (Convert to Mouse Ab)">Murinization (Convert to Mouse Ab)</a></li><li class="navi-menu-li-3"><a href="/chimeric-IgG-generation.html" title="Chimeric Antibody Conversion">Chimeric Antibody Conversion</a></li><li class="navi-menu-li-3"><a href="/scfv-fab-generation.html" title="ScFv/Fab Conversion">ScFv/Fab Conversion</a></li></ul></li><li class="navi-menu-li-2 col-md-4 col-lg-4 col-sm-4"><a href="/engineering-services.html" title="Property Optimization">Property Optimization</a><ul class="navi-menu-3 three_menu"><li class="navi-menu-li-3"><a href="/antibody-affinity-maturation.html" title="Affinity Maturation">Affinity Maturation</a><ul class="navi-menu-4 three_menu"><li class="navi-menu-li-4"><a href="/sdab-affinity-maturation.html" title="Single Domain Antibody (SdAb) Affinity Maturation">Single Domain Antibody (SdAb) Affinity Maturation</a></li></ul></li><li class="navi-menu-li-3"><a href="/Antibody-Stability-Improvement.html" title="Stability Improvement">Stability Improvement</a><ul class="navi-menu-4 three_menu"><li class="navi-menu-li-4"><a href="/single-domain-antibody-stability-improvement-service.html" title="Single Domain Antibody (SdAb) Stability Improvement">Single Domain Antibody (SdAb) Stability Improvement</a></li></ul></li><li class="navi-menu-li-3"><a href="/scaffold-specificity-optimization-service.html" title="Specificity Optimization">Specificity Optimization</a></li><li class="navi-menu-li-3"><a href="/Custom-Cysteine-Modification-in-Antibody.html" title="Cysteine Modification">Cysteine Modification</a></li><li class="navi-menu-li-3"><a href="/yeast-display-based-t-cell-receptor-engineering-service.html" title="T Cell Receptor Engineering">T Cell Receptor Engineering</a></li><li class="navi-menu-li-3"><a href="/drug-discovery/therapeutics/fc-engineering-service.htm" title="Fc Engineering">Fc Engineering</a></li></ul></li><li class="navi-menu-li-2 col-md-4 col-lg-4 col-sm-4"><a href="/bioconjugation/" title="Labeling/Conjugation">Labeling/Conjugation</a></li></ul> </li> <li class="col-md-4 col-lg-4 col-sm-4"> <b class="Highlights_tit">Services</b> <p class="open-sans-light"> Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects. </p>  <b class="Highlights_tit">Highlights</b> <ul class="HighlightsArea"> <li class="col-md-6 col-lg-6 col-sm-6"> <img src="static/images/Solutions-menu-lights-pic-1.jpg" srcset="static/images/Solutions-menu-lights-pic-1.webp 1x" width="201" height="131" loading="lazy"><a href="discovery-services.html" class="bannerbutton"><i class="fa fa-angle-right"></i>Discovery Services</a> </li> <li class="col-md-6 col-lg-6 col-sm-6"> <img src="static/images/Solutions-menu-lights-pic-2.jpg" srcset="static/images/Solutions-menu-lights-pic-2.webp 1x" width="201" height="131" loading="lazy"><a href="engineering-services.html" class="bannerbutton"> <i class="fa fa-angle-right"></i>Engineering Services </a> </li> </ul> </li> </ul> </div> </div> </li> <li> <span>Custom Production & Manufacturing</span> <div class="secondMenu"> <div class="second-menu-area-box"> <ul style="margin-top:0;">  <li class="col-md-8 col-lg-8 col-sm-8"> <ul class="navi-menu-2 MenuList"><li class="navi-menu-li-2 col-md-4 col-lg-4 col-sm-4"><a href="javascript:void(0)" title="Custom Production">Custom Production</a><ul class="navi-menu-3 three_menu"><li class="navi-menu-li-3"><a href="javascript:void(0)" title="Membrane Protein Preparation">Membrane Protein Preparation</a><ul class="navi-menu-4 three_menu"><li class="navi-menu-li-4"><a href="/Custom-GPCR-Production-Service.html" title="GPCR Preparation">GPCR Preparation</a></li><li class="navi-menu-li-4"><a href="/Custom-Ion-Channel-Protein-Production-Service.html" title="Ion Channel Preparation">Ion Channel Preparation</a></li><li class="navi-menu-li-4"><a href="/Membrane-Transport-Proteins.html" title="Transporter Preparation">Transporter Preparation</a></li><li class="navi-menu-li-4"><a href="/Membrane-Protein-Production.html" title="Custom Membrane Protein Production">Custom Membrane Protein Production</a></li><li class="navi-menu-li-4"><a href="/magic-membrane-protein-solubilization-and-stabilization.html" title="Custom Membrane Protein Solubilization and Stabilization">Custom Membrane Protein Solubilization and Stabilization</a></li><li class="navi-menu-li-4"><a href="/magic-membrane-protein-functional-validation.html" title="Custom Membrane Protein QC">Custom Membrane Protein QC</a></li></ul></li><li class="navi-menu-li-3"><a href="/Virus-like-Particles.html" title="Virus Like Particle (VLP) Production">Virus Like Particle (VLP) Production</a><ul class="navi-menu-4 three_menu"><li class="navi-menu-li-4"><a href="/virus-like-particles-vlps-production-in-insect-cell-system.html" title="Insect Cell based VLP Production">Insect Cell based VLP Production</a></li><li class="navi-menu-li-4"><a href="/virus-like-particles-vlps-production-in-mammalian-cell-system.html" title="Mammalian Cell based VLP Production">Mammalian Cell based VLP Production</a></li><li class="navi-menu-li-4"><a href="/virus-like-particles-vlps-production-in-e-coli-system.html" title="<i>E. coli</i> based VLP Production"><i>E. coli</i> based VLP Production</a></li><li class="navi-menu-li-4"><a href="/virus-like-particles-vlps-production-in-yeast-cell-system.html" title="Yeast Cell based VLP Production">Yeast Cell based VLP Production</a></li><li class="navi-menu-li-4"><a href="/virus-like-particles-vlps-production-in-plant-system.html" title="Plant Cell based VLP Production">Plant Cell based VLP Production</a></li></ul></li><li class="navi-menu-li-3"><a href="/Antibody-Production-Services.html" title="Recombinant Antibody Production">Recombinant Antibody Production</a></li><li class="navi-menu-li-3"><a href="/bulk-antibody-production-by-ascites.html" title="Ascites Fluid based Antibody Production">Ascites Fluid based Antibody Production</a></li><li class="navi-menu-li-3"><a href="/Stable-Cell-Line-Services.html" title="Stable Cell Line Construction">Stable Cell Line Construction</a></li></ul></li><li class="navi-menu-li-2 col-md-4 col-lg-4 col-sm-4"><a href="/bio-manufacturing.html" title="Manufacturing">Manufacturing</a><ul class="navi-menu-3 three_menu"><li class="navi-menu-li-3"><a href="/Manufacturability-Assessment.htm" title="Manufacturability Assessment and Optimization">Manufacturability Assessment and Optimization</a><ul class="navi-menu-4 three_menu"><li class="navi-menu-li-4"><a href="/virtual-prediction-of-manufacturability-assessment-and-improvement.html" title="Virtual Prediction">Virtual Prediction</a></li><li class="navi-menu-li-4"><a href="/amino-acid-sequence-and-terminal-sequence-analysis.html" title="Amino Acid & Terminal Sequence Analysis">Amino Acid & Terminal Sequence Analysis</a></li></ul></li></ul></li></ul> </li> <li class="col-md-4 col-lg-4 col-sm-4"> <b class="Highlights_tit">Services</b> <p class="open-sans-light"> Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects. </p>  <b class="Highlights_tit">Highlights</b> <ul class="HighlightsArea"> <li class="col-md-6 col-lg-6 col-sm-6"> <img src="static/images/Solutions-menu-lights-pic-1.jpg" srcset="static/images/Solutions-menu-lights-pic-1.webp 1x" width="201" height="131" loading="lazy"><a href="discovery-services.html" class="bannerbutton"><i class="fa fa-angle-right"></i>Discovery Services</a> </li> <li class="col-md-6 col-lg-6 col-sm-6"> <img src="static/images/Solutions-menu-lights-pic-2.jpg" srcset="static/images/Solutions-menu-lights-pic-2.webp 1x" width="201" height="131" loading="lazy"><a href="engineering-services.html" class="bannerbutton"> <i class="fa fa-angle-right"></i>Engineering Services </a> </li> </ul> </li> </ul> </div> </div> </li> <li> <span>Products</span> <div class="secondMenu"> <div class="second-menu-area-box"> <ul style="margin-top:0;"> <li class="col-md-8 col-lg-8 col-sm-8"> <ul class="navi-menu-2 MenuList"><li class="navi-menu-li-2 col-md-4 col-lg-4 col-sm-4"><a href="/category-premade-phage-display-library-ready-to-use-kits-4.htm" title="Phage Display Library Ready-To-Use Kits">Phage Display Library Ready-To-Use Kits</a></li><li class="navi-menu-li-2 col-md-4 col-lg-4 col-sm-4"><a href="/category-premade-yeast-display-library-ready-to-use-kits-6.htm" title="Yeast Display Library Ready-To-Use Kits">Yeast Display Library Ready-To-Use Kits</a></li><li class="navi-menu-li-2 col-md-4 col-lg-4 col-sm-4"><a href="/category-recombinant-antibody-products-2.htm" title="Recombinant Antibody Products">Recombinant Antibody Products</a></li><li class="navi-menu-li-2 col-md-4 col-lg-4 col-sm-4"><a href="/category-membrane-protein-products-11.htm" title="Membrane Protein Products">Membrane Protein Products</a><ul class="navi-menu-3 three_menu"><li class="navi-menu-li-3"><a href="/category-nativeextract-membrane-protein-products-38.htm" title="Full-Length Membrane Protein (Super Nanodisc)">Full-Length Membrane Protein (Super Nanodisc)</a></li><li class="navi-menu-li-3"><a href="/category-gpcrs-protein-products-20.htm" title="GPCR Protein">GPCR Protein</a></li><li class="navi-menu-li-3"><a href="/category-transporter-protein-products-21.htm" title="Transporter Protein">Transporter Protein</a></li><li class="navi-menu-li-3"><a href="/category-ion-channel-protein-products-22.htm" title="Ion Channel Protein">Ion Channel Protein</a></li><li class="navi-menu-li-3"><a href="/category-car-t-therapy-target-protein-products-23.htm" title="CAR-T Therapy Target Protein">CAR-T Therapy Target Protein</a></li><li class="navi-menu-li-3"><a href="/category-biomarkers-and-cd-protein-products-24.htm" title="Biomarkers and CD Protein">Biomarkers and CD Protein</a></li><li class="navi-menu-li-3"><a href="/category-fc-receptor-protein-products-25.htm" title="Fc Receptor Protein">Fc Receptor Protein</a></li><li class="navi-menu-li-3"><a href="/category-hla-protein-products-26.htm" title="HLA Protein">HLA Protein</a></li><li class="navi-menu-li-3"><a href="/category-cell-free-protein-products-27.htm" title="Cell-Free Protein">Cell-Free Protein</a></li><li class="navi-menu-li-3"><a href="/category-mp-vlps-products-28.htm" title="MP-VLP">MP-VLP</a></li><li class="navi-menu-li-3"><a href="/category-other-membrane-protein-products-29.htm" title="Other Membrane Protein">Other Membrane Protein</a></li></ul></li><li class="navi-menu-li-2 col-md-4 col-lg-4 col-sm-4"><a href="/category-membrane-protein-expression-kits-30.htm" title="Membrane Protein Expression Kits">Membrane Protein Expression Kits</a><ul class="navi-menu-3 three_menu"><li class="navi-menu-li-3"><a href="/category-magic-cell-free-membrane-protein-expression-kits-32.htm" title="Cell-Free Membrane Protein Expression Kits">Cell-Free Membrane Protein Expression Kits</a></li></ul></li><li class="navi-menu-li-2 col-md-4 col-lg-4 col-sm-4"><a href="/category-membrane-protein-solubilization-and-stabilization-reagents-33.htm" title="Membrane Protein Solubilization & Stabilization Reagents">Membrane Protein Solubilization & Stabilization Reagents</a><ul class="navi-menu-3 three_menu"><li class="navi-menu-li-3"><a href="/category-detergents-34.htm" title="Detergent">Detergent</a></li><li class="navi-menu-li-3"><a href="/category-phospholipids-35.htm" title="Phospholipid">Phospholipid</a></li><li class="navi-menu-li-3"><a href="/category-nanodiscs-36.htm" title="Nanodisc">Nanodisc</a></li><li class="navi-menu-li-3"><a href="/category-polymer-37.htm" title="Polymer">Polymer</a></li></ul></li><li class="navi-menu-li-2 col-md-4 col-lg-4 col-sm-4"><a href="/category-membrane-protein-stable-cell-line-products-10.htm" title="Membrane Protein Stable Cell Line Products">Membrane Protein Stable Cell Line Products</a></li><li class="navi-menu-li-2 col-md-4 col-lg-4 col-sm-4"><a href="/adc/classify-products-5.htm" title="Antibody-Drug Conjugate (ADC) Products">Antibody-Drug Conjugate (ADC) Products</a></li></ul> </li> <li class="col-md-4 col-lg-4 col-sm-4"> <b class="Highlights_tit">Products</b><p class="open-sans-light"> With over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. </p> <b class="Highlights_tit">Highlights</b> <ul class="HighlightsArea"> <li class="col-md-6 col-lg-6 col-sm-6"> <img src="static/images/Products-menu-lights-pic-1.jpg" srcset="static/images/Products-menu-lights-pic-1.webp 1x" width="200" height="131" loading="lazy"><a href="Premade-single-domain-antibody-library.html" class="bannerbutton"> <i class="fa fa-angle-right"></i>sdAb Libraries </a> </li> <li class="col-md-6 col-lg-6 col-sm-6"> <img src="static/images/Products-menu-lights-pic-2.jpg" srcset="static/images/Products-menu-lights-pic-2.webp 1x" width="200" height="131" loading="lazy"><a href="Immunized-Human-Antibody-Library.html" class="bannerbutton"> <i class="fa fa-angle-right"></i>Immunized hAb Libraries </a> </li> </ul> </li> </ul> </div> </div> </li> <li> <span>Platforms</span> <div class="secondMenu"> <div class="second-menu-area-box"> <ul style="margin-top:0;"> <li class="col-md-8 col-lg-8 col-sm-8"> <ul class="navi-menu-2 MenuList"><li class="navi-menu-li-2 col-md-4 col-lg-4 col-sm-4"><a href="/Phage-Display-Platform.html" title="Phage Display Platform">Phage Display Platform</a></li><li class="navi-menu-li-2 col-md-4 col-lg-4 col-sm-4"><a href="/yeast-display-platform.html" title="Yeast Display Platform">Yeast Display Platform</a></li><li class="navi-menu-li-2 col-md-4 col-lg-4 col-sm-4"><a href="/Hybridoma-Platform.html" title="Hybridoma Platform">Hybridoma Platform</a></li><li class="navi-menu-li-2 col-md-4 col-lg-4 col-sm-4"><a href="/b-cell-sorting-platform.html" title="Single B Cell Sorting Platform">Single B Cell Sorting Platform</a></li><li class="navi-menu-li-2 col-md-4 col-lg-4 col-sm-4"><a href="/Membrane-Protein-Platform.html" title="Membrane Protein Platform">Membrane Protein Platform</a></li></ul> </li> <li class="col-md-4 col-lg-4 col-sm-4"> <b class="Highlights_tit"> Platforms </b> <p class="open-sans-light"> Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects. </p>  <b class="Highlights_tit">Highlights</b> <ul class="HighlightsArea"> <li class="col-md-6 col-lg-6 col-sm-6"> <img src="static/images/Platforms-menu-lights-pic-1.jpg" srcset="static/images/Platforms-menu-lights-pic-1.webp 1x" width="201" height="131" loading="lazy"><a href="b-cell-sorting-platform.html" class="bannerbutton"><i class="fa fa-angle-right"></i>B-Cell Sorting Platform</a> </li> <li class="col-md-6 col-lg-6 col-sm-6"> <img src="static/images/Platforms-menu-lights-pic-2.jpg" srcset="static/images/Platforms-menu-lights-pic-2.webp 1x" width="201" height="131" loading="lazy"><a href="Phage-Display-Platform.html" class="bannerbutton"><i class="fa fa-angle-right"></i>Phage Display Platform</a> </li> </ul> </li> </ul> </div> </div> </li> <li> <span>Resources</span> <div class="secondMenu"> <div class="second-menu-area-box">  <ul style="margin-top:0;"> <li class="col-md-8 col-lg-8 col-sm-8"> <ul class="navi-menu-2 MenuList"><li class="navi-menu-li-2 col-md-4 col-lg-4 col-sm-4"><a href="/Peer-reviewed-Publications.html" title="Peer-Reviewed Publications">Peer-Reviewed Publications</a></li><li class="navi-menu-li-2 col-md-4 col-lg-4 col-sm-4"><a href="/faq.htm" title="Frequently Asked Questions (FAQs)">Frequently Asked Questions (FAQs)</a><ul class="navi-menu-3 three_menu"><li class="navi-menu-li-3"><a href="/antibody-antigen-faq.htm" title="Antibody & Antigen FAQ">Antibody & Antigen FAQ</a></li><li class="navi-menu-li-3"><a href="/surface-technology-faq.html" title="Surface Technology FAQ">Surface Technology FAQ</a></li><li class="navi-menu-li-3"><a href="/antibody-service-faq.html" title="Antibody Service FAQ">Antibody Service FAQ</a></li></ul></li><li class="navi-menu-li-2 col-md-4 col-lg-4 col-sm-4"><a href="javascript:void(0)" title="Resource Download">Resource Download</a><ul class="navi-menu-3 three_menu"><li class="navi-menu-li-3"><a href="/conference-resources.html" title="Conference Resources">Conference Resources</a></li><li class="navi-menu-li-3"><a href="/support-documents.html" title="Support Documents">Support Documents</a></li><li class="navi-menu-li-3"><a href="/newsletter.aspx" title="Newsletter">Newsletter</a></li></ul></li><li class="navi-menu-li-2 col-md-4 col-lg-4 col-sm-4"><a href="/knowledge-center.html" title="Knowledge Hub">Knowledge Hub</a><ul class="navi-menu-3 three_menu"><li class="navi-menu-li-3"><a href="/protocol.html" title="Protocol Instances">Protocol Instances</a></li><li class="navi-menu-li-3"><a href="/technology-introductions.html" title="Technology Introductions">Technology Introductions</a></li><li class="navi-menu-li-3"><a href="/background-knowledges.html" title="Background Knowledges">Background Knowledges</a></li><li class="navi-menu-li-3"><a href="/antibody-overviews.html" title="Antibody Overviews">Antibody Overviews</a></li><li class="navi-menu-li-3"><a href="/membrane-protein-types-introduction.html" title="Membrane Protein Overviews">Membrane Protein Overviews</a></li><li class="navi-menu-li-3"><a href="/scaffold-overviews.html" title="Scaffold Overviews">Scaffold Overviews</a></li></ul></li><li class="navi-menu-li-2 col-md-4 col-lg-4 col-sm-4"><a href="javascript:void(0)" title="Host Spot Insight">Host Spot Insight</a><ul class="navi-menu-3 three_menu"><li class="navi-menu-li-3"><a href="/literature.html" title="Literature Review">Literature Review</a></li><li class="navi-menu-li-3"><a href="/hot-topics.html" title="Hot Topics">Hot Topics</a></li></ul></li><li class="navi-menu-li-2 col-md-4 col-lg-4 col-sm-4"><a href="/podcast.html" title="Podcast">Podcast</a><ul class="navi-menu-3 three_menu"><li class="navi-menu-li-3"><a href="/surface-display-technology-podcasts.html" title="Surface Display Technology">Surface Display Technology</a></li><li class="navi-menu-li-3"><a href="/recombinant-antibody.html" title="Recombinant Antibody">Recombinant Antibody</a></li><li class="navi-menu-li-3"><a href="/therapeutic-antibody.html" title="Therapeutic Antibody">Therapeutic Antibody</a></li><li class="navi-menu-li-3"><a href="/de-novo-antibody-sequencing.html" title="<i>De Novo</i> Antibody Sequencing"><i>De Novo</i> Antibody Sequencing</a></li><li class="navi-menu-li-3"><a href="/membrane-protein.html" title="Membrane Protein">Membrane Protein</a></li></ul></li></ul> </li> <li class="col-md-4 col-lg-4 col-sm-4"> <b class="Highlights_tit"> Resources </b> <p class="open-sans-light"> With deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions. </p>  <b class="Highlights_tit">Highlights</b> <ul class="HighlightsArea"> <li class="col-md-6 col-lg-6 col-sm-6"> <img src="static/images/Resources-menu-lights-pic-1.jpg" srcset="static/images/Resources-menu-lights-pic-1.webp 1x" width="201" height="131" loading="lazy"><a href="Peer-reviewed-Publications.html" class="bannerbutton"><i class="fa fa-angle-right"></i>Peer-Reviewed Publications</a> </li> <li class="col-md-6 col-lg-6 col-sm-6"> <img src="static/images/Resources-menu-lights-pic-2.jpg" srcset="static/images/Resources-menu-lights-pic-2.webp 1x" width="201" height="131" loading="lazy"><a href="support-documents.html" class="bannerbutton"><i class="fa fa-angle-right"></i>Support Documents</a> </li> </ul> </li> </ul> </div> </div> </li> <li> <span>Company</span> <div class="secondMenu"> <div class="second-menu-area-box"> <ul style="margin-top:0;">  <li class="col-md-8 col-lg-8 col-sm-8"> <ul class=" MenuList"> <li class="col-md-4 col-lg-4 col-sm-4"><a href="aboutus.html" rel="nofollow">About Creative Biolabs</a> <ul class="navi-menu-2 three_menu"> <li class="navi-menu-li-2"><a href="/Licensing-and-Collaboration.html" title="Licensing and Collaboration">Licensing and Collaboration</a></li> </ul> </li> <li class="col-md-4 col-lg-4 col-sm-4"><a href="contactus.html" rel="nofollow">Contact Us</a></li> <li class="col-md-4 col-lg-4 col-sm-4"><a href="Distributors.html" rel="nofollow">Distributors</a></li> <li class="col-md-4 col-lg-4 col-sm-4"><a href="feedback.aspx">Reviews & Endorsements</a></li> <li class="col-md-4 col-lg-4 col-sm-4"><a href="/career/career.aspx" rel="nofollow">Careers</a> </li> <li class="col-md-4 col-lg-4 col-sm-4"><a href="https://events.creative-biolabs.com" rel="nofollow">Events</a></li> <li class="col-md-4 col-lg-4 col-sm-4"><a href="scholarship-program.html">Scholarship Program</a></li> <li class="col-md-4 col-lg-4 col-sm-4"><a href="creative-biolabs-corporate-social-responsibility.html">Corporate Social Responsibility</a></li> </ul> </li> <li class="col-md-4 col-lg-4 col-sm-4"> <b class="Highlights_tit"> About Us </b> <p class="open-sans-light"> Get a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects. </p> <b class="Highlights_tit">Highlights</b> <ul class="HighlightsArea"> <li class="col-md-6 col-lg-6 col-sm-6"> <img src="static/images/Abouts-menu-lights-pic-1.jpg" srcset="static/images/Abouts-menu-lights-pic-1.webp 1x" width="200" height="131" loading="lazy"><a href="aboutus.html" class="bannerbutton"> <i class="fa fa-angle-right"></i>About CBL </a> </li> <li class="col-md-6 col-lg-6 col-sm-6"> <img src="static/images/Abouts-menu-lights-pic-2.jpg" srcset="static/images/Abouts-menu-lights-pic-2.webp 1x" width="200" height="131" loading="lazy"><a href="contactus.html" class="bannerbutton"> <i class="fa fa-angle-right"></i>Contact Us </a> </li> </ul> </li> </ul> </div> </div> </li> </ul> <script> window.addEventListener('load',function(){ var arr = ['/drug-discovery/therapeutics/','/bioconjugation/','/adc/']; $('.mennav ul li a').each(function(){ var $this = $(this); var href = $this.attr("href").toLocaleLowerCase(); $.each(arr, function(index, value) { if (href && href.startsWith(value)) { $this.attr('target', '_blank'); } }); }); }); </script> </div> <div class="top-search search-group"> <div class="col-md-5 col-sm-6"> <label class="radio-inline"><input type="radio" name="search" class="rdo_productsearch" value="product" data-type="product" placeholder="Please input cat#, product name, abbr, or keywords."> Product</label> <label class="radio-inline"><input type="radio" name="search" class="rdo_servicesearch" value="service" data-type="service" placeholder="Please input your keywords."> Service</label> <label class="radio-inline"><input type="radio" name="search" class="rdo_googlesearch" value="google" data-type="google" placeholder="Please input your keywords." checked="checked"> Keyword</label> </div> <div class="col-md-7 col-sm-6 search-div"> <input id="keys" name="keys" placeholder="Please input your keywords." class="search-input"> <div class="selectItems"></div> <span class="search_btn"><i class="fa fa-search"></i></span> </div> </div> </div> <div class="searchShow"> <div class="searchtopbg"></div> <span class="searchclosed"><i class="fa fa-times"></i>Close</span> <div class="addsearch search-group"></div> </div> <div class="banner_inpage services_bg_2"> <div class="auto-container small_content-width about_container"> <ul class="bread-crumb clearfix"> <li><a href="/">Home</a></li> <li><a href="javascrpt:void(0)">Characterization</a></li><li><a href="/immunologic-analysis-services.html">Immunogenicity Analysis</a></li> <li>De-immunization</li> </ul> <p>"Creative Biolabs is committed to providing highly customized comprehensive solutions with the best quality to advance our global clients’ projects."</p> </div> </div> <script> window.addEventListener('load', function () { if (($('.bread-crumb li:last-child').text()) == "Peer-Reviewed Publications") { $(".banner_inpage").addClass("peer-reviewed-publications_bg").removeClass("services_bg_2"); } if ($(window).hasClass('bread-crumb')) { if ($(".bread-crumb").html().indexOf("RESOURCE") > -1) { $(".pronote").hide(); } if ($(".bread-crumb").html().indexOf("Careers") > -1) { $(".pronote").hide(); } } }); </script> <div class="small_content-width services-container"> <div class="col-md-9"> <div class="inpage_section_title"> <h1>RDIT<sup>®</sup> De-immunization Services</h1> </div> <div class="page-tab"> <span onclick="window.location.href=window.location.pathname+'#tab1'">Background</span> <span onclick="window.location.href=window.location.pathname+'#tab2'">Antibody Drug De-immunization</span> <span onclick="window.location.href=window.location.pathname+'#tab3'">Peptide and Protein Drugs De-immunization</span> <span onclick="window.location.href=window.location.pathname+'#tab4'">Published Data</span> <span onclick="window.location.href=window.location.pathname+'#tab5'">FAQ</span> <span onclick="window.location.href=window.location.pathname+'#tab6'">Resources</span> </div> <script>window.addEventListener('load',function(){page_tab_css();page_tab_margin();})</script> <h2 class="h2_tit page_tab_margin" id="tab1"> Background </h2> <p> The immunogenicity of biotherapeutic drugs is a significant problem during clinical applications. Many biotherapeutic drugs can develop unwanted immune responses in patients such as the generation of anti-drug antibodies (ADAs), which results in treatment resistance and potentially life-threatening adverse effects. Although different techniques, including advanced technologies for the expression, purification, and formulation of recombinant proteins, and the use of purely human or humanized proteins, have been developed to reduce the immunogenicity of biotherapeutic drugs, the problems remain to be completely eliminated. For instance, fully human antibodies, produced by phage display technology or transgenic mice, may still show degrees of immunogenicity. </p> <p> One of the main drivers of immunogenicity is the presence of human T cell epitopes in the protein sequence, which can activate helper T cells, thus continuously producing antibodies and neutralizing therapeutic effects. De-immunization is a new technology combining immunology and molecular biology to locate and remove T cell epitopes. <strong>Creative Biolabs</strong> offers a number of de-immunization services to assist our clients in reducing the immunogenicity of biotherapeutic drug candidates. Our service has been widely used to remove the T cell epitopes from biotherapeutic drugs while preserving their therapeutic efficacy. </p> <p class="show-center"> <img loading="lazy" src="static/img/RDIT-De-immunization-Services-1.png" width="350" height="189" alt="Recognition and binding of antibody versus T cell epitopes occur via separate molecular mechanisms. " /> Fig.1 Recognition and binding of antibody versus T cell epitopes occur <em>via</em> separate molecular mechanisms. (Griswold, 2016) </p> <h2 class="h2_tit page_tab_margin" id="tab2"> <a href="/rdit-antibody-drug-de-immunization-services.html">RDIT<sup>®</sup> Antibody Drug De-immunization Services</a> </h2> <p> We employ novel, innovative and classic methods to reduce the immunogenicity of candidate antibody drugs by combining immunology and molecular biology techniques. In the case of antibody de-immunization, the mutation of the T cell epitope can be introduced without significantly reducing the binding affinity of the antibody. In general, "de-immunized" antibodies are produced by the expression of human constant regions and genes encoding these antibodies in mammalian cells. At present, our experienced scientists have established a systematic process to develop an immune antibody produced in various expression systems. With a wealth of experience and profound expertise, we will be of great assistance for the advancement of your promising drug candidate into clinical trials. </p> <h2 class="h2_tit page_tab_margin" id="tab3"> <a href="/rdit-peptide-and-protein-drugs-de-immunization-services.html">RDIT<sup>®</sup> Peptide and Protein Drugs De-immunization Services</a> </h2> <p> In addition to antibody drugs, therapeutic peptides and proteins are powerful next-generation drugs that can effectively treat a variety of devastating diseases, but the development and use of biotherapeutics entail unique challenges and risks. In particular, protein drugs are monitored by the immune system in the human body and the following anti-drug immune response will cause a wide range of problems, including pharmacokinetic changes, drug efficacy loss, and even life-threatening complications. Therefore, various methods have been taken to reduce or eliminate the immunogenicity of these drugs. Based on the detailed understanding of the cellular and molecular mechanisms underlying the anti-drug immune response, our RDIT<sup>®</sup> platform can be used to "delete" protein epitopes to enable the strategy of protein immunity. </p> <p> <strong>Creative Biolabs</strong> offers comprehensive and professional technology for your drug de-immunization needs. We are honored to provide you with a customized schedule to help you with your research. If you are interested in our RDIT<sup>®</sup> de-immunization service, please <a class="inquiry-button">contact us</a> for more information. </p> <h2 class="h2_tit page_tab_margin" id="tab4"> Published Data </h2> <ul class="ullist"> <li> <strong>Identification of New Epitopes within the VACV p35 Protein by Deimmunization</strong> </li> </ul> <p class="show-center"> <img loading="lazy" src="static/img/1-2-8-4-rdit-de-immunization-services-2.jpg" width="550" height="253" alt="" />Fig. 2 Characterization of pooled anti-rp35Δ sera after depletion.<sup>2,3</sup> </p> <p> The research in this study highlights the potential of de-immunized Vaccinia virus (VACV) as an oncolytic agent for cancer therapy. The article describes the identification of new epitopes within the VACV p35 protein that are crucial for virus neutralization. Specifically, it was found that altering certain amino acids in the p35 protein can lead to the generation of VACV variants that are less recognizable by neutralizing antibodies, thereby enhancing the virus's ability to evade the immune response. This strategy of de-immunization is significant as it helps to maintain the oncolytic activity of VACV while reducing its immunogenicity, making it a more effective tool for cancer therapy. By modifying the virus to escape immune detection, it can potentially improve the efficacy and safety of VACV-based therapies in oncological applications. </p> <div class="reference"> <strong>References</strong> <ol class="ollist decimal"> <li> Griswold, K. E., Bailey-Kellogg, C. Design and engineering of deimmunized biotherapeutics. <em>Current opinion in structural biology</em>. 2016, 39: 79-88. </li> <li> Khlusevich, Yana, et al. "New p35 (H3L) epitope involved in vaccinia virus neutralization and its deimmunization." <em>Viruses</em> 14.6 (2022): 1224. </li> <li> under Open Access license <a href="https://creativecommons.org/licenses/by/4.0/">CC BY 4.0</a>, without modification. </li> </ol> </div> <script type="text/javascript"> window.addEventListener('load',function(){ faqlist(4); }); </script> <h2 class="h2_tit page_tab_margin" id="tab5"> FAQ </h2> <ol class="ollist faqlist"> <li> <span class="sFAQTit">What is de-immunization in the context of biotherapeutics?</span> <p> De-immunization involves modifying biotherapeutic agents, such as proteins or peptides, to reduce their immunogenicity without compromising their therapeutic efficacy. This process helps prevent the immune system from recognizing and attacking these agents, thereby enhancing their safety and effectiveness. </p> </li> <li> <span class="sFAQTit">Why is de-immunization important for biotherapeutic drugs?</span> <p> De-immunization helps minimize adverse immune reactions, such as the development of anti-drug antibodies that can neutralize the therapeutic effects of the drug or cause allergic reactions. This increases the therapeutic window and improves patient compliance and outcomes. </p> </li> <li> <span class="sFAQTit">How is de-immunization achieved in protein therapeutics?</span> <p> De-immunization can be achieved by altering amino acid sequences in the protein to remove T-cell epitopes or by glycosylation to shield epitopes from the immune system. Techniques such as site-directed mutagenesis or computational modeling are often used to identify and modify immunogenic regions. </p> </li> <li> <span class="sFAQTit">What are T-cell epitopes, and why are they targeted in de-immunization?</span> <p> T-cell epitopes are short sequences of amino acids in proteins that are recognized by T-cell receptors when presented by MHC molecules. Targeting these epitopes for modification in the de-immunization process helps reduce the likelihood of the immune system initiating a response against the therapeutic protein. </p> </li> <li> <span class="sFAQTit">Can de-immunization affect the functionality of biotherapeutics?</span> <p> While de-immunization aims to retain the therapeutic efficacy of biotherapeutics, modifications to protein structures can sometimes alter their biological activity or stability. It's essential to balance immunogenicity reduction with maintaining the drug's functional integrity, which requires careful design and extensive testing. </p> </li> <li> <span class="sFAQTit">What role does computational biology play in de-immunization?</span> <p> Computational biology helps predict the immunogenic potential of protein therapeutics and identifies regions within the protein that could be modified to reduce immunogenicity. This allows for a rational design of de-immunized proteins, reducing the need for extensive trial-and-error in the lab. </p> </li> <li> <span class="sFAQTit">How is de-immunization verified experimentally?</span> <p> De-immunization is typically verified by immunological assays that test the reactivity of the modified protein with serum from immunized individuals or by using in silico tools to predict immunogenicity. Additionally, functional assays are necessary to ensure that the therapeutic efficacy of the protein remains intact. </p> </li> <li> <span class="sFAQTit">Are there any successful examples of de-immunized biotherapeutics on the market?</span> <p> Several engineered antibody therapies have been successfully de-immunized to reduce immunogenicity and are currently available on the market. These include modified monoclonal antibodies and fusion proteins designed to be less immunogenic while retaining their therapeutic properties, thereby improving patient outcomes and reducing side effects related to immune responses. </p> </li> </ol> <h2 class="h2_tit page_tab_margin" id="tab6"> Resources </h2> <p> Use the resources in our library to help you understand your options and make critical decisions for your study. </p> <div class="tab_nav"> <span class="tab_choosebg">Videos</span><span>Articles</span> </div>  <div class="tab_cont" style="display:block;"> <div class="row pagerow_pt"> <div class="col-md-4"> <div class="pagerow_pt_unit"> <img loading="lazy" src="../static/img/immunogenicity-overview-of-therapeutic-biologics.jpg" alt="" /> </div> <a href="https://youtu.be/J430752_dTo" target="_blank">Immunogenicity overview of therapeutic biologics</a> </div> </div> </div>  <div class="tab_cont"> <div class="row pagerow_pt"> <div class="col-md-4"> <div class="pagerow_pt_unit_2"> <img loading="lazy" src="static/img/4-2-14-immune-monitoring-for-immunogenicity-assessment-1.jpg" alt="" /> </div> <a href="/immune-monitoring-for-immunogenicity-assessment.html">Immune Monitoring for Immunogenicity Assessment</a> </div> <div class="col-md-4"> <div class="pagerow_pt_unit_2"> <img loading="lazy" src="static/img/4-2-14-current-immunogenicity-evaluation-systems-a-deep-dive-by-creative-biolabs-1.jpg" alt="" /> </div> <a href="/current-immunogenicity-evaluation-systems.html">Current Immunogenicity Evaluation Systems: A Deep Dive by Creative Biolabs</a> </div> <div class="col-md-4"> <div class="pagerow_pt_unit_2"> <img loading="lazy" src="static/img/4-2-14-1-in-silico-immunogenicity-assessment-the-leading-edge-approach-to-drug-development-1.jpg" alt="" /> </div> <a href="/in-silico-immunogenicity-assessment-the-leading-edge-approach-to-drug-development.html"><i>In Silico</i> Immunogenicity Assessment: The Leading-edge Approach to Drug Development</a> </div> <div class="col-md-4"> <div class="pagerow_pt_unit_2"> <img loading="lazy" src="static/img/4-2-14-4-how-to-evaluate-the-immunogenicity-of-therapeutic-protein-drugs-in-vivo-1.jpg" alt="" /> </div> <a href="/how-to-evaluate-the-immunogenicity-of-therapeutic-protein-drugs-in-vivo.html">How to Evaluate the Immunogenicity of Therapeutic Protein Drugs <i>In Vivo</i></a> </div> <div class="col-md-4"> <div class="pagerow_pt_unit_2"> <img loading="lazy" src="static/img/4-2-14-5-the-origin-and-detection-methods-of-anti-drug-antibodies-1.jpg" alt="" /> </div> <a href="/the-origin-and-detection-methods-of-anti-drug-antibodies.html">The Origin and Detection Methods of Anti-Drug Antibodies</a> </div> <div class="col-md-4"> <div class="pagerow_pt_unit_2"> <img loading="lazy" src="static/img/4-2-14-1-8-immunogenic-risk-assessment-of-therapeutic-proteins-1.jpg" alt="" /> </div> <a href="/immunogenic-risk-assessment-of-therapeutic-proteins.html">Immunogenic Risk Assessment of Therapeutic Proteins</a> </div> <div class="col-md-4"> <div class="pagerow_pt_unit_2"> <img loading="lazy" src="static/img/anti-drug-antibody-introduction-1.jpg" alt="" /> </div> <a href="/anti-drug-antibody-introduction.html">Anti-Drug Antibody Introduction</a> </div> </div> </div> <script> window.addEventListener('load',function(){ // $(function () { $(".tab_nav span").click(function(){ var eqindex=$(this).index(); $(this).addClass("tab_choosebg"); $(this).siblings("span").removeClass("tab_choosebg"); $(".tab_cont").hide().eq(eqindex).show(); }) // }) }); </script><br> <p class="pronote"><i class="fa fa-exclamation-triangle"></i>All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.</p> </div> <div class="col-md-3"> <a name="OnlineInquiry"></a> <div class="rightcontact inquiry_bg_small"> <div class="rig_tit">Online Inquiry</div> <link rel="preconnect" href="https://www.recaptcha.net" /> <style type="text/css">.grecaptcha-badge { opacity: 0; }</style> <script src="https://www.recaptcha.net/recaptcha/enterprise.js?render=6LdtbowmAAAAABp2LeBkVvRNBQvLXkSG5aExNWHk"></script> <script> function grecaptchaFormBinding(formName, callback, event, action='submit_form') { if (event != undefined) { event.preventDefault ? event.preventDefault() : (event.returnValue = false); } var _form = document.forms[formName]; if (_form != undefined) { grecaptcha.enterprise.ready(function () { grecaptcha.enterprise.execute('6LdtbowmAAAAABp2LeBkVvRNBQvLXkSG5aExNWHk', { action: action.length > 0 ? action : 'submit_form' }).then(function (token) { if (_form['g-recaptcha-response'] === undefined) { var _response_input = document.createElement('input'); _response_input.setAttribute('type', 'hidden'); _response_input.setAttribute('name', 'g-recaptcha-response'); _response_input.setAttribute('readonly', 'readonly'); _response_input.setAttribute('value', token); _form.appendChild(_response_input); } else { _form['g-recaptcha-response'].value = token; } if (callback != undefined) { callback(); } }); }); } } </script>  <script> window.addEventListener('load', function () { jQuery(document).ready(function () { jQuery("#formID").validationEngine("attach", { promptPosition: "bottomLeft", scroll: false, autoHidePrompt: true, autoHideDelay: 3000 }); // binds form submission and fields to the validation engine jQuery("#formID").validationEngine(); $("#formID").bind("jqv.form.validating", function (event) { $("#hookError").html(""); }); $("#formID").bind("jqv.form.result", function (event, errorFound) { if (errorFound) { $("#hookError").append("There is some problems with your form"); } }); $("#formID").submit(function (e) { if ($('#formID').validationEngine('validate')) { $(this).find(":submit").prop("disabled", true); grecaptchaFormBinding('orderform', function () { document.forms['orderform'].submit(); }, e); } //$(this).find(":submit").prop("disabled", false); e.preventDefault ? e.preventDefault() : (e.returnValue = false); return false; }); }); }); </script> <form role="form" id="formID" name="orderform" class="Inquiry_form" method="post" action="/form/pub.aspx" autocomplete="off"> <input type="hidden" id="inquirytoken" name="inquirytoken" value="MU1J1YOr" /> <input type="hidden" name="inquiryType" value="service"> <input type="hidden" name="cat" value=""> <input type="hidden" name="pn" value="" /> <input type="hidden" name="pn_url" value="" /> <div class="row"> <div class="col-md-12"> <label for="Phone">Name</label> <input type="text" placeholder="Name" name="I_Name" id="I_Name" /> </div> <div class="col-md-12"> <label for="Phone"><span class="red">*</span> Phone</label> <input type="text" name="I_Phone" id="I_Phone" placeholder="Phone" class="form-control input-md inputborderSecond validate[required] text-input" /> </div> <div class="col-md-12"> <label for="Email"><span class="red">*</span> Email</label> <input type="text" placeholder="Email" name="email" id="email" class="form-control input-md form-control inputborderSecond validate[required,custom[email]] text-input" /> </div> <div class="col-md-12"> <label><span class="red">*</span> Products or Services Interested:</label> <input type="text" name="I_Subject" id="I_Subject" placeholder="Products or Services Interested" value="RDIT® De-immunization Services" class="form-control input-md inputborderSecond validate[required] text-input" /> </div> <div class="col-md-12"> <label>Project Description</label> <textarea name="I_Message{EXT:[IEXT_Description]}" id="I_Message" placeholder="Project Description" cols="40" rows="4"></textarea> </div> <div class="col-md-12"> <input type="hidden" name="I_Codenumber" value="P01" /> <input type="hidden" name="I_From Codenumber" value="" /> <button class="submit" type="submit">Send</button> <script src="https://static.creative-biolabs.com/_noindex/google-verification/verification.js" type="text/javascript"></script> <div style="clear: both;"></div> </div> </div> </form> </div> <div class="rightcontact"> <div class="rig_tit">CONTACT US</div> <table width="100%" border="0" cellspacing="0" cellpadding="0" style="border:0px;"> <tr> <td valign="top"><i class="fa fa-map-marker-alt"></i></td> <td valign="top"><strong>USA:</strong> <span cbl-addr-usa></span> <br> <strong>Europe:</strong> <span cbl-addr-uk></span><br> <strong>Germany</strong>: <span cbl-addr-germany></span> </td> </tr> <tr> <td valign="top"><i class=" fa fa-phone"></i></td> <td valign="top"> Call us at:<br> USA: <span cbl-tel-usa1478></span> <br> UK: <span cbl-tel-uk></span> <br> Germany: <span cbl-tel-germany></span> <br> </td> </tr> <tr> <td valign="top"><i class=" fa fa-fax"></i></td> <td valign="top"> Fax: <span cbl-fax></span> <br> </td> </tr> <tr> <td valign="top"><i class="fa fa-envelope"></i></td> <td valign="top"> Email: <a cbl-email class="a_link"></a> </td> </tr> </table> </div> </div> </div> <div class="promisebottom">Our customer service representatives are available 24 hours a day, 7 days a week. <a href="contactus.html" class="signup">Contact Us</a></div> <div class="contact_bottom"> <div class=" bottom_colum"> <div class="content-width"> <ul> <li> <b class="bottom_tit">Services<span></span></b> <ul> <li><a href="/phage-display-library-construction.html">Phage Display Library Construction</a></li> <li><a href="/phage-display-library-screening.html">Phage Display Library Screening</a></li> <li><a href="/Hybridoma-Services.html">Hybridoma Services</a></li> <li><a href="/Membrane-Protein-Service.html">Magic™ Anti-Membrane Protein Antibody Discovery</a></li> <li><a href="/Production-of-Anti-idiotype-Antibody.html">Anti-idiotype Antibody Discovery</a></li> <li><a href="/Nanobody-Single-Domain-Antibody.html">Single Domain Antibody (sdAb) Discovery</a></li> <li><a href="/Native-TM-Antibody-Discovery-Service.html">Native™ Antibody Discovery</a></li> <li><a href="/Next-Generation-Antibody-Sequencing.html"><em>De Novo</em> Antibody Sequencing</a></li> <li><a href="/antibody-humanization.html">Antibody Humanization</a></li> <li><a href="/antibody-affinity-maturation.html">Antibody Affinity Maturation</a></li> <li> <a href="/Custom-antibody-services-for-post-translational-modification-specific-antibody-discovery.html">Post-Translational Modification (PTM) Specific Antibody Discovery</a></li> </ul> </li> <li> <b class="bottom_tit">Platforms<span></span></b> <ul> <li><a href="Phage-Display-Platform.html">Phage Display Platform</a></li> <li><a href="Membrane-Protein-Platform.html">Membrane Protein Platform</a></li> <li><a href="hyperdoma-a-high-throughput-hybridoma-generation-platform.html">Hyperdoma™ Platform</a></li> <li><a href="b-cell-sorting-platform.html">B-Cell Sorting Platform</a></li> </ul> <b class="bottom_tit">Help & Support<span></span></b> <ul>  <li><a href="/faq.htm">Frequently Asked Questions (FAQs)</a></li> <li><a href="/support-documents.html">Support Documents</a></li> <li><a href="/knowledge-center.html">Knowledge Center</a></li> <li><a href="/newsletter.aspx">Newsletter</a></li> <li><a href="/protocol.html">Protocol</a></li> <li><a href="/literature.html">Literature</a></li> </ul> </li> <li class="bottom_contac_info"> <b class="bottom_tit">Contact us</b> <strong>USA</strong> <span cbl-addr-usa></span> <br> Tel: <span cbl-tel-usa1478></span> <br> Fax: <span cbl-fax></span> <br> Email: <a cbl-email class="a_link"></a> <strong>UK</strong> <span cbl-addr-uk></span> <br> Tel: <span cbl-tel-uk></span> <br> Email: <a cbl-email class="a_link"></a> <strong>Germany</strong> <span cbl-addr-germany></span> <br> Tel: <span cbl-tel-germany></span> <br> Email: <a cbl-email class="a_link"></a> </li> <li> <b class="bottom_tit">Subscribe to Our Newsletter for Updates:</b> <input type="text" class="letterinput" id="subscribeemail" placeholder="email@example.com"> <button type="button" class="newsletterbutton" onclick="javacript:subscribe('subscribeemail','Creative Biolabs','www.creative-biolabs.com')">Sign Up Now</button> <div class="iso"> <img src="https://www.cblcdn.com/images/ISO90012015.png" srcset="https://www.cblcdn.com/images/ISO90012015.webp 1x, https://www.cblcdn.com/images/ISO90012015.webp 2x, https://www.cblcdn.com/images/ISO90012015.webp 3x" width="200" alt="ISO 9001 Certified - Creative Biolabs Quality Management System" loading="lazy"> </div> </li> </ul> </div> </div> <script> window.addEventListener('load', function () { $(function () { var bottomspan=$(".bottom_tit span"); bottomspan.on("click",function(){ $(this).toggleClass("arrw"); $(this).parent(".bottom_tit").siblings("ul").toggle(100); }) }) }) </script> <div class="clear"></div> </div> <div class="indexfoot"> <div class="content-width"> <div class="col-md-9 col-sm-9 col-lg-9"> © 2024 Creative Biolabs. | <a href="contactus.html">Contact Us</a> </div> <link href="https://static.creative-biolabs.com/icon/style.css?v=1.0.202402" rel="stylesheet" type="text/css" /> <div class="col-md-3 col-sm-3 col-lg-3"> <span class="social-icon-two"> <a target="_blank" href="https://www.facebook.com/CreativeBiolabs" data-wow-duration="2s" aria-label="Learn more from facebook"><span class="icon-facebook"></span></a> <a target="_blank" href="https://twitter.com/CreativeBiolabs" aria-label="twitter"><span class="icon-twitter-x"></span></a> <a target="_blank" href="http://www.linkedin.com/company/creative-biolabs/" aria-label="Learn more from linkedin"><span class="icon-linkedin"></span></a> <a target="_blank" href="https://www.youtube.com/@CreativeBiolabs" aria-label="Learn more from youtube"><span class="icon-youtube"></span></a> <a target="_blank" href="/blog/" aria-label="Learn more from blog"><span class="icon-blogger"></span></a> </span> </div> </div> </div>  <link rel="stylesheet" type="text/css" href="static/css/public-new.css?t=D20190703" async> <link rel="stylesheet" type="text/css" href="static/css/bootstrap.min.css?t=D20190703" async> <link rel="stylesheet" type="text/css" href="static/css/fontawesome-all.min.css?t=D20190703" async> <script src="static/js/jquery-3.1.1.min.js"></script> <link href="/static/css/validationEngine.jquery.css" rel="stylesheet" async/> <script src="/static/js/jquery.validationEngine-en.js" async></script> <script src="/static/js/jquery.validationEngine.js" async></script> <script src="https://static.creative-biolabs.com/js/ahref.js" type="text/javascript" defer></script> <script> const loadContact = () => { if (typeof contactInformation !== 'undefined') new contactInformation({ opts: { messTags: ['cbl-addr-usa', 'cbl-tel-usa1478', 'cbl-tel-usa2254', 'cbl-tel-usa5530', 'cbl-tel-usa9819', 'cbl-fax', 'cbl-email', 'cbl-addr-uk', 'cbl-tel-uk', 'cbl-addr-germany', 'cbl-tel-germany' ], mainFix:"www.creative-biolabs.com" } }); } </script> <script src="https://www.cblcdn.com/_noindex/contact/base64Decryption.js" onload="loadContact();" async></script> <script src="static/js/navimenu.js" type="text/javascript" async></script> <script src="static/js/auto.js" type="text/javascript" async></script> <script src="static/js/base.js?v=1.0.05302" type="text/javascript" async></script> <script src="static/js/scrolltopcontrol.js" type="text/javascript" defer></script> <script> privacy_policy_config = {name: "3g7R9s", debug: true, url: "https://go.creative-biolabs.com/privacy-policy?website=com&domain=www.creative-biolabs.com&contact=marketemail_7b95a2ac8713cd7a3fdc04ba95ccdf9d"}; </script> <script src="https://www.cblcdn.com/_noindex/jquery.privacy.policy-v.js?v=1.0.202402" defer></script> </body> </html>

CINXE.COM

RDIT® De-immunization Services - Creative Biolabs