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Hepatovirus ~ ViralZone
<!DOCTYPE html> <html lang="en"> <head> <meta http-equiv="Content-Type" content="text/html;charset=utf-8"/> <meta name="google-site-verification" content="NtyZwlqH6NZhGoT3FbOe53w-9G0avnGJyUZ3A2ih2m4"/> <meta name="author" content="Philippe Le Mercier, Chantal Hulo, Patrick Masson (content); Edouard de Castro (software)"/> <meta name="description" content="A knowledge resource to understand virus diversity and a gateway to UniProtKB/Swiss-Prot viral entries"/> <meta name="keywords" content="virus, viral, infection, cycle, biology, uniprotkb"/> <meta name="viewport" content="width=device-width, initial-scale=1.0"/> <title>Hepatovirus ~ ViralZone</title> <link rel="shortcut icon" href="https://web.expasy.org/favicon.ico"/> <link href="/resources/css/viralzone.css" rel="stylesheet" type="text/css"/> <script src="/resources/js/zone.js"></script> </head> <body id="taball" vocab="http://schema.org/" typeof="WebPage"> <script>init_tabs()</script> <div id="container"> <div id="header"> <div id="h1"> <a href="/"><img alt="Viralzone" src="/resources/images/viralzone.jpg"/></a> <div id="search"> <form action="/search" method="get" property="potentialAction" typeof="SearchAction"> <a href="/doc/search" target="_blank" rel="noopener"><img style="vertical-align:middle" alt="search help" src="/resources/images/qm.png"/></a> <input class="suggest" data-suggest-path="/search/suggest" type="text" name="query" size="24" value="" placeholder="e.g.: sphere / "11 segments" / 10979 / cat OR dog / nucleo* / autofagy~"/> <input type="submit" value="search"/> </form> </div> </div> <div id="h2"> <div id="sib_expasy_logo"> <a href="https://www.sib.swiss" id="sib_link" title="SIB Swiss Institute of Bioinformatics"></a> <a href="https://www.expasy.org" id="expasy_link" title="ExPASy - SIB Bioinformatics Resource Portal"></a> </div> </div> <div id="h3"> <a title="About Us" href="/872">About Us</a> <a title="Contact Us" href="/contact">Contact Us</a> <a title="Home" href="/">Home</a> <a title="follow us on twitter" href="https://twitter.com/viralzone"><img src="/resources/images/tfollow.png" alt="twitter"/></a> </div> <div id="announce"></div> </div> <div id="tab_bar"> </div> <div class="page"> <div class="core" id="core"> <div property="mainEntity" typeof="CreativeWork"> <h1 class="root" property="name" content="Hepatovirus ViralZone page" data-about="taxid:12091">Hepatovirus<a class="locinfo" href="https://www.uniprot.org/taxonomy/12091"> (taxid:12091)</a></h1> <span property="about" typeof="Thing" resource="http://purl.uniprot.org/taxonomy/12091"></span> <div id="wiki"><div id="t0"> <div class="main"> <summary><b>Hepatovirus</b> is a genus of ssRNA+ viruses in the Picornaviridae family that infect vertebrates. In humans, hepatitis A virus cause mild hepatitis.</summary> <h4 id="VIRION">VIRION</h4> <p><img class="inline_svg" src="/resources/Hepatovirus%5Fvirion.svg" alt="image" /></p> <div class="hidden"> <img class="in_preview" src="/resources/Picornaviridae%5Fvirion.png" alt="image" /> </div> <p>Non-enveloped, spherical, about 30 nm in diameter, <a href="/by%5Fprotein/809">T=pseudo3 icosahedral capsid</a> surrounding the naked RNA genome. The capsid consists of a densely-packed icosahedral arrangement of 60 protomers, each consisting of 3 polypeptides, VP1, VP2, and VP3. VP4 does not seem to be incorporated into virions. </br> <a href="https://viperdb.org/Genus%5FIndex.php?GenCom=Hepatovirus"><img src="/resources/viperdb.svg" alt="image" /></a></p> <h4 id="GENOME">GENOME</h4> <p><img class="inline_svg" src="/resources/Hepatovirus%5Fgenome.svg" alt="image" /></p> <p>Monopartite, linear <a href="/by%5Fprotein/245">ssRNA(+) genome</a> of 7.478 kb, polyadenylated, composed of a single ORF encoding a polyprotein. Viral genomic RNA has a viral protein (VPg) at its 5' end instead of a methylated nucleotide cap structure. The long UTR at the 5' end contains a type III <a href="/by%5Fspecies/867">internal ribosome entry site (IRES)</a>. The P1 region encodes the structural polypeptides. The P2 and P3 regions encode the nonstructural proteins associated with replication. Encodes a unique protease 3C. The shorter 3' UTR is polyadenylated and is important in (-)strand synthesis.</p> <h4 id="GENE_EXPRESSION">GENE EXPRESSION</h4> <p>The virion RNA is infectious and serves as both the genome and viral messenger RNA. The <a href="/by%5Fspecies/867">IRES</a> allows direct translation of the polyprotein. The polyprotein is initially processed by the viral protease into three precursor proteins, P1, P2, and P3. Precursor P1 is then proteolytically cleaved to yield the structural proteins. Precursors P2 and P3 are processed into replicase, VPg, and a number of proteins that modify the host cell, ultimately leading to <a href="/by%5Fspecies/1077">cell lysis</a>. <br/> Unlike other picornaviruses, HAV needs the eIF4G factor for the initiation of translation and thus cannot shut down host protein synthesis. HAV displays highly deoptimized codon usage. The resulting slow translation rate probably contributes to the high stability of viral capsid and may play a role in escaping to host cell defenses <A HREF="http://www.ncbi.nlm.nih.gov/pubmed/17524513"><IMG BORDER=0 SRC="/resources/Pubmed.gif"></A>.</p> <h4 id="ENZYMES">ENZYMES</h4> <ul> <li><a href="/by%5Fprotein/10557">RNA-dependent RNA polymerase</a> [<a href="https://www.uniprot.org/uniprotkb/P08617">RdRp</a>] <li><a href="/by%5Fprotein/10178">VPG-type capping</a> [<a href="https://www.uniprot.org/uniprotkb/P08617">VPg</a>] <li><a href="/by%5Fprotein/10517">NTPase-helicase</a> [<a href="https://www.uniprot.org/uniprotkb/P08617">2C</a>] <li><a href="/by%5Fprotein/10438">Polyprotein major protease (Peptidase C3)</a> [<a href="https://www.uniprot.org/uniprotkb/P08617">3Cpro</a>] </ul> <h4 id="REPLICATION">REPLICATION</h4> <p><strong style="color:Salmon">CYTOPLASMIC</strong></p> <ol style="list-style-type:decimal"> <li><a href="/by%5Fprotein/956">Attachement</a> of the virus to <a href="/by%5Fprotein/958">host receptors</a> mediates <a href="/by%5Fprotein/977">endocytosis of the virus into the host cell</a> possibly by <a href="/by%5Fprotein/957">clathrin-dependent endocytosis</a>.</li> <li>Upon endosomal acidification, the capsid undergoes a conformational change and releases VP4 that opens a <a href="/by%5Fprotein/979">pore in the host endosomal membrane</a> and the viral genomic RNA penetrates into the host cell cytoplasm.</li> <li>VPg is removed from the viral RNA, which is then translated into a processed polyprotein.</li> <li>Replication occurs in <a href="/by%5Fprotein/1951">viral factories</a> made of membrane vesicles derived from the ER. A dsRNA genome is synthesized from the genomic ssRNA(+).</li> <li>The dsRNA genome is <a href="/by%5Fspecies/1116">transcribed/replicated</a> thereby providing viral mRNAs/new ssRNA(+) genomes.</li> <li>New genomic RNA is believed to be packaged into <a href="/by%5Fprotein/1950">preassembled procapsids</a>.</li> <li><a href="/by%5Fspecies/1077">Cell lysis</a> and virus release.</li> <li><a href="/by%5Fprotein/1946">Maturation</a> of provirions by an unknown host protease.</li> </ol> </div> <div class="sidebar"> <fieldset> <legend><strong>DB LINKS</strong></legend> <a href="https://www.ncbi.nlm.nih.gov/labs/virus/vssi/#/virus?SeqType%5Fs=Nucleotide&VirusLineage%5Fss=taxid:12091"><img src="/resources/ncbi-virus.svg" alt="image" /></a> <a href="http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=12091"><img style="float:right;" src="/resources/ncbi-taxo.svg" alt="image" /></a> </br> </br> <a href="https://www.uniprot.org/uniprotkb?query=taxonomy%5Fid%3A12091"><img src="/resources/uniprot-rgb.svg" alt="image" /></a> <a href="https://ictv.global/taxonomy/taxondetails?taxnode%5Fid=202202002&taxon%5Fname=Hepatovirus"><img style="float:right;" src="/resources/ICTV-logo.svg" alt="image" /></a> </br> </br><a href="https://www.bv-brc.org/view/Taxonomy/12091"><img src="/resources/BV%5FBRC.svg" alt="image" /></a> <a href="https://ictv.global/report/chapter/picornaviridae/picornaviridae/hepatovirus"><img style="float:right;" src="/resources/ICTV%5Freport.svg" alt="image" /></a> </br> </br> <a href="https://viro3d.cvr.gla.ac.uk/resultspage/viruses/hepatovirus"><img src="/resources/Viro3D.svg" alt="image" /></a> </fieldset> <fieldset> <legend><strong>TAXONOMY</strong></legend> Group IV; ssRNA positive-strand viruses <TABLE> <TR><TD WIDTH=30%>Realm: </TD><TD><i>Riboviria</i></TD></TR> <TR><TD WIDTH=30%>Kingdom: </TD><TD><i>Orthornavirae</i></TD></TR> <TR><TD WIDTH=30%>Phylum: </TD><TD><i><a href="/by%5Fprotein/294">Pisuviricota</a></i></TD></TR> <TR><TD WIDTH=30%>Class: </TD><TD><i>Pisoniviricetes</i></TD></TR> <TR><TD WIDTH=30%>Order: </TD><TD><i>Picornavirales</i></TD></TR> <TR><TD WIDTH=30%>Family:</TD><TD><i><a href="/by%5Fprotein/33">Picornaviridae</a></i></TD></TR> <TR><TD WIDTH=30% Valign=top>Genus:</TD><TD> <i><strong>Hepatovirus</strong></i> </TD></TR> </TABLE> </fieldset> <fieldset> <legend><strong>VIRUS</strong></legend> <div> <div id="species" class=""> <span> <strong><span><em>Hepatovirus A</em><br/></span></strong> </span><span> <span><em>Hepatovirus B</em><br/></span> </span><span> <span><em>Hepatovirus C</em><br/></span> </span><span> <span><em>Hepatovirus D</em><br/></span> </span><span> <span><em>Hepatovirus E</em><br/></span> </span><span> <span><em>Hepatovirus F</em><br/></span> </span><span> <span><em>Hepatovirus G</em><br/></span> </span><span> <span><em>Hepatovirus H</em><br/></span> </span><span> <span><em>Hepatovirus I</em><br/></span> </span> </div> </div> </fieldset> <fieldset style="border: 1px ridge #FF0000;"> <legend style="color: #FF0000;"><strong>REFERENCE STRAIN</strong></legend> Hepatitis A virus <br> <a href="http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NC%5F001489">Sequence</a> | <a href="https://www.ncbi.nlm.nih.gov/datasets/genome/GCF%5F000860505">Genome assembly</a> | <a href="https://www.uniprot.org/uniprotkb/?query=xref:embl-M14707">Proteome</a> </fieldset> <h2 id="Host" class="i1">Host</h2> <fieldset> <legend><strong>NATURAL HOSTS</strong></legend> Human, Vertebrates </fieldset> <fieldset> <legend><strong>TROPISM</strong></legend> <ins>Primary site of infection</ins>: Liver.<br> </fieldset> <fieldset> <legend><strong>INTERACTIONS</strong></legend> <ins>Cell receptors</ins>: <br/> <span style="color:Purple">HAV</span>: <a href="http://www.uniprot.org/uniprot/O46598">HAVCR1</a> <A HREF="http://www.ncbi.nlm.nih.gov/pubmed/8861957"><IMG BORDER=0 SRC="/resources/Pubmed.gif"></A> <br> <span style="color:Purple">SHAV</span>: <a href="http://www.uniprot.org/uniprot/O46598">HAVcr-1</a> </br> <a href="#tab2" onclick="set('tab2')"><ins>Host-virus interaction</ins></a> </fieldset> <h2 id="Ecology_and_disease" class="i1">Ecology and disease</h2> <fieldset> <legend><strong>GEOGRAPHY</strong></legend> worldwide </fieldset> <fieldset> <legend><strong>ASSOCIATED DISEASES</strong></legend> Hepatitis A virus: Mild <a href="https://en.wikipedia.org/wiki/Common%5Fcold">hepatitis</a>. Rarely, fulminate acute hepatitis.<br> Avian encephalomyelitis virus: Reduced hatching. Tremors and/or ataxia. </fieldset> <fieldset> <legend><strong>TRANSMISSION</strong></legend> Fecal-oral, blood. </fieldset> <fieldset> <legend><strong>VACCINE</strong></legend> Hepatitis A virus. </fieldset> <fieldset> <legend><strong>ANTIVIRAL DRUGS</strong></legend> - </fieldset> </div> </div> <div id="t2" title="Host-virus interaction"> <div class="main"> <h2 id="Host_virus_interaction">Host-virus interaction</h2> <h4 id="Apoptosis_modulation">Apoptosis modulation</h4> <p>Picornaviruses <a href="/by%5Fprotein/1581">modulate host apoptosis</a> <A HREF="http://www.ncbi.nlm.nih.gov/pubmed/16337385"><IMG BORDER=0 SRC="/resources/Pubmed.gif"></A>.</p> <h4 id="Autophagy_modulation">Autophagy modulation</h4> <p>Picornaviruses <a href="/by%5Fprotein/1596">subvert the cell autophagic pathway</a> to facilitates viral infection <A HREF="http://www.ncbi.nlm.nih.gov/pubmed/18094610"><IMG BORDER=0 SRC="/resources/Pubmed.gif"></A>:</p> <h4 id="Innate_immune_response_inhibition">Innate immune response inhibition</h4> <p>HAV <a href="/by%5Fprotein/875">inhibits the host IFN-mediated response</a> by <a href="/by%5Fprotein/704">cleaving MAVS</a> <A HREF="http://www.ncbi.nlm.nih.gov/pubmed/17438296"><IMG BORDER=0 SRC="/resources/Pubmed.gif"></A> <br/></p> <p>HAV inhibits Toll-like receptor 3 mediated antiviral response cleaving TRIF <A HREF="http://www.ncbi.nlm.nih.gov/pubmed/21436888"><IMG BORDER=0 SRC="/resources/Pubmed.gif"></A> <A HREF="http://www.ncbi.nlm.nih.gov/pubmed/21931545"><IMG BORDER=0 SRC="/resources/Pubmed.gif"></A> <A HREF="http://www.ncbi.nlm.nih.gov/pubmed/21697485"><IMG BORDER=0 SRC="/resources/Pubmed.gif"></A>.</p> </div> <div class="sidebar"> <fieldset> <legend><strong>GENERAL</strong></legend> <a href="" onclick="set('tab1')">Back to hepatovirus page</a> </fieldset> <fieldset> <legend><strong>NATURAL HOSTS</strong></legend> Human, Vertebrates </fieldset> <fieldset> <legend><strong>TROPISM</strong></legend> <ins>Primary site of infection</ins>: Liver.<br> </fieldset> <fieldset> <legend><strong>INTERACTIONS</strong></legend> <ins>Cell receptors</ins>: <br/> <span style="color:Purple">HAV</span>: <a href="http://www.uniprot.org/uniprot/O46598">HAVCR1</a> <A HREF="http://www.ncbi.nlm.nih.gov/pubmed/8861957"><IMG BORDER=0 SRC="/resources/Pubmed.gif"></A> <br> <span style="color:Purple">SHAV</span>: <a href="http://www.uniprot.org/uniprot/O46598">HAVcr-1</a> </fieldset> <fieldset> <legend><strong>ASSOCIATED DISEASES</strong></legend> Hepatitis A virus: Mild <a href="http://en.wikipedia.org/wiki/Common%5Fcold">hepatitis</a>. Rarely, fulminate acute hepatitis.<br> Avian encephalomyelitis virus: Reduced hatching. Tremors and/or ataxia. </fieldset> <fieldset> <legend><strong>TRANSMISSION</strong></legend> Fecal-oral, blood. </fieldset> </div> </div></div> <div class="matches" id="t6" title="Proteins by Strain"><div> <h2 class="root"> Matching UniProtKB/Swiss-Prot entries </h2> <small class="note1">(all links/actions below point to <a href="https://www.uniprot.org">uniprot.org</a> website)</small> <p> <a href="https://www.uniprot.org/uniprotkb/?query=taxonomy_id:12091+AND+reviewed:true+AND+fragment:false&fields=organism_name,accession,id,protein_name,keyword,xref_pdb">10 entries</a> grouped <strong>by strain</strong> </p> <div id="t7" title="Proteins by Name"><a href="/94?outline=all_by_protein#tab7">reorder by protein</a></div> <div> <p class="upcount">1 entry</p> <h3 class="upgroup uc">Human hepatitis A virus genotype IB (isolate HM175) (HHAV) (Human hepatitis A virus (isolate Human/Australia/HM175/1976)) <span class="ref_strain">reference strain</span> </h3> <form class="_form" action="" method="post"> <input class="_form_action_retrieve" value="Retrieve" type="submit"/> <input class="_form_action_map" value="Map2NucleicAcid" type="submit"/> <div> <div class="protein_list"> <span class="protein"> <input name="q" value="P08617" type="checkbox"/> <a href="https://www.uniprot.org/uniprotkb/P08617" title="UniProt P08617">POLG_HAVHM</a> </span> <span class="description c"><span>Genome polyprotein [Cleaved into: Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion <span class="truncated">...</span></span></span> </div> <div class="xrefs" title="PDB links"> <p class="note"> <img alt="pdb" src="/resources/images/bullet-pdb.png"/> <a class="note" title="PDB" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=1HAV">1HAV</a><span>; </span><a class="note" title="PDB" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=1QA7">1QA7</a><span>; </span><a class="note" title="PDB" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=2H6M">2H6M</a><span>; </span><a class="note" title="PDB" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=2H9H">2H9H</a><span>; </span><a class="note" title="PDB" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=2HAL">2HAL</a><span>; </span><a class="note" title="PDB" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=4QPG">4QPG</a><span>; </span><a class="note" title="PDB" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=4QPI">4QPI</a><span>; </span><a class="note" title="PDB" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=4WZN">4WZN</a><span>; </span><a class="note" title="PDB" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=5WTE">5WTE</a><span>; </span><a class="note" title="PDB" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=5WTF">5WTF</a><span>; </span><a class="note" title="PDB" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=5WTH">5WTH</a><span>; </span><a class="note" title="PDB" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=7XT3">7XT3</a> </p> </div> </div> </form> </div><div> <p class="upcount">1 entry</p> <h3 class="upgroup uc">Human hepatitis A virus genotype IA (isolate GBM) (HHAV) (Human hepatitis A virus (isolate Human/Germany/GBM/1976)) </h3> <form class="_form" action="" method="post"> <input class="_form_action_retrieve" value="Retrieve" type="submit"/> <input class="_form_action_map" value="Map2NucleicAcid" type="submit"/> <div> <div class="protein_list"> <span class="protein"> <input name="q" value="Q67825" type="checkbox"/> <a href="https://www.uniprot.org/uniprotkb/Q67825" title="UniProt Q67825">POLG_HAVGB</a> </span> <span class="description c"><span>Genome polyprotein [Cleaved into: Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion <span class="truncated">...</span></span></span> </div> </div> </form> </div><div> <p class="upcount">1 entry</p> <h3 class="upgroup uc">Human hepatitis A virus genotype IA (isolate H2) (HHAV) (Human hepatitis A virus (isolate Human/China/H2/1982)) </h3> <form class="_form" action="" method="post"> <input class="_form_action_retrieve" value="Retrieve" type="submit"/> <input class="_form_action_map" value="Map2NucleicAcid" type="submit"/> <div> <div class="protein_list"> <span class="protein"> <input name="q" value="A3FMB2" type="checkbox"/> <a href="https://www.uniprot.org/uniprotkb/A3FMB2" title="UniProt A3FMB2">POLG_HAVH2</a> </span> <span class="description c"><span>Genome polyprotein [Cleaved into: Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion <span class="truncated">...</span></span></span> </div> </div> </form> </div><div> <p class="upcount">1 entry</p> <h3 class="upgroup uc">Human hepatitis A virus genotype IA (isolate LA) (HHAV) (Human hepatitis A virus (isolate Human/Northern California/LA/1974)) </h3> <form class="_form" action="" method="post"> <input class="_form_action_retrieve" value="Retrieve" type="submit"/> <input class="_form_action_map" value="Map2NucleicAcid" type="submit"/> <div> <div class="protein_list"> <span class="protein"> <input name="q" value="P06441" type="checkbox"/> <a href="https://www.uniprot.org/uniprotkb/P06441" title="UniProt P06441">POLG_HAVLA</a> </span> <span class="description c"><span>Genome polyprotein [Cleaved into: Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion <span class="truncated">...</span></span></span> </div> </div> </form> </div><div> <p class="upcount">1 entry</p> <h3 class="upgroup uc">Human hepatitis A virus genotype IB (isolate MBB) (HHAV) (Human hepatitis A virus (isolate Human/Northern Africa/MBB/1978)) </h3> <form class="_form" action="" method="post"> <input class="_form_action_retrieve" value="Retrieve" type="submit"/> <input class="_form_action_map" value="Map2NucleicAcid" type="submit"/> <div> <div class="protein_list"> <span class="protein"> <input name="q" value="P13901" type="checkbox"/> <a href="https://www.uniprot.org/uniprotkb/P13901" title="UniProt P13901">POLG_HAVMB</a> </span> <span class="description c"><span>Genome polyprotein [Cleaved into: Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion <span class="truncated">...</span></span></span> </div> <div class="xrefs" title="PDB links"> <p class="note"> <img alt="pdb" src="/resources/images/bullet-pdb.png"/> <a class="note" title="PDB" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=2A4O">2A4O</a><span>; </span><a class="note" title="PDB" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=2CXV">2CXV</a> </p> </div> </div> </form> </div><div> <p class="upcount">1 entry</p> <h3 class="upgroup uc">Human hepatitis A virus genotype IIA (isolate CF-53) (HHAV) (Human hepatitis A virus (isolate Human/France/CF-53/1979)) </h3> <form class="_form" action="" method="post"> <input class="_form_action_retrieve" value="Retrieve" type="submit"/> <input class="_form_action_map" value="Map2NucleicAcid" type="submit"/> <div> <div class="protein_list"> <span class="protein"> <input name="q" value="Q5Y944" type="checkbox"/> <a href="https://www.uniprot.org/uniprotkb/Q5Y944" title="UniProt Q5Y944">POLG_HAVCF</a> </span> <span class="description c"><span>Genome polyprotein [Cleaved into: Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion <span class="truncated">...</span></span></span> </div> </div> </form> </div><div> <p class="upcount">1 entry</p> <h3 class="upgroup uc">Human hepatitis A virus genotype IIB (isolate SLF88) (HHAV) (Human hepatitis A virus (isolate Human/Sierra Leone/SLF88/1988)) </h3> <form class="_form" action="" method="post"> <input class="_form_action_retrieve" value="Retrieve" type="submit"/> <input class="_form_action_map" value="Map2NucleicAcid" type="submit"/> <div> <div class="protein_list"> <span class="protein"> <input name="q" value="Q8V0N6" type="checkbox"/> <a href="https://www.uniprot.org/uniprotkb/Q8V0N6" title="UniProt Q8V0N6">POLG_HAV88</a> </span> <span class="description c"><span>Genome polyprotein [Cleaved into: Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion <span class="truncated">...</span></span></span> </div> </div> </form> </div><div> <p class="upcount">1 entry</p> <h3 class="upgroup uc">Human hepatitis A virus genotype IIIA (isolate NOR-21) (HHAV) (Human hepatitis A virus (isolate Human/Norway/NOR-21/1998)) </h3> <form class="_form" action="" method="post"> <input class="_form_action_retrieve" value="Retrieve" type="submit"/> <input class="_form_action_map" value="Map2NucleicAcid" type="submit"/> <div> <div class="protein_list"> <span class="protein"> <input name="q" value="Q9DWR1" type="checkbox"/> <a href="https://www.uniprot.org/uniprotkb/Q9DWR1" title="UniProt Q9DWR1">POLG_HAVNO</a> </span> <span class="description c"><span>Genome polyprotein [Cleaved into: Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion <span class="truncated">...</span></span></span> </div> </div> </form> </div><div> <p class="upcount">1 entry</p> <h3 class="upgroup uc">Human hepatitis A virus genotype IIIB (isolate HAJ85-1) (HHAV) (Human hepatitis A virus (isolate Human/Japan/HAJ85-1/1985)) </h3> <form class="_form" action="" method="post"> <input class="_form_action_retrieve" value="Retrieve" type="submit"/> <input class="_form_action_map" value="Map2NucleicAcid" type="submit"/> <div> <div class="protein_list"> <span class="protein"> <input name="q" value="A5LGW7" type="checkbox"/> <a href="https://www.uniprot.org/uniprotkb/A5LGW7" title="UniProt A5LGW7">POLG_HAVJ8</a> </span> <span class="description c"><span>Genome polyprotein [Cleaved into: Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion <span class="truncated">...</span></span></span> </div> </div> </form> </div><div> <p class="upcount">1 entry</p> <h3 class="upgroup uc">Simian hepatitis A virus genotype V (isolate AGM-27) (SHAV) (Simian hepatitis A virus (isolate Cercopithecus/Kenya/AGM-27/1985)) </h3> <form class="_form" action="" method="post"> <input class="_form_action_retrieve" value="Retrieve" type="submit"/> <input class="_form_action_map" value="Map2NucleicAcid" type="submit"/> <div> <div class="protein_list"> <span class="protein"> <input name="q" value="P14553" type="checkbox"/> <a href="https://www.uniprot.org/uniprotkb/P14553" title="UniProt P14553">POLG_HAVS2</a> </span> <span class="description c"><span>Genome polyprotein [Cleaved into: Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion <span class="truncated">...</span></span></span> </div> </div> </form> </div> </div></div> <div class="matches" id="t8" title="3D Models"> <fieldset>These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna <a lang="576744" href="https://www.biorxiv.org/content/10.1101/2024.01.22.576744v1"> <img border="0" src="/resources/Pubmed.gif"/></a> (<a href="https://modelarchive.org/doi/10.5452/ma-jd-viral">ModelArchive</a>). </fieldset> <h2 class="notice4">hepatovirus B1 <a class="locinfo" href="https://www.uniprot.org/taxonomy/1708572">taxid:1708572</a></h2><table id="ma_1708572" class="bicolor1"> <thead> <tr> <td>Protein</td> <td>ModelArchive</td> </tr> </thead> <tr> <td><a title="" href="https://www.uniprot.org/uniprotkb/A0A0M3R836">Genome polyprotein</a></td> <td><a title="" href="https://www.modelarchive.org/doi/10.5452/ma-jd-viral-30863">ma-jd-viral-30863</a></td> </tr> </table> </div> </div> </div> </div> </div> <div id="sib_footer"> <div id="sib_footer_content"> <div property="creator" typeof="NGO"> ViralZone is operated by the <a href="https://www.sib.swiss/alan-bridge-group" property="url"><span property="name">Swiss-Prot group</span></a> of the <a href="https://www.sib.swiss" property="url">SIB Swiss Institute of Bioinformatics</a> | <a href="/872#License__amp__Disclaimer" class="external-link" target="_blank" rel="nofollow noopener">License & Disclaimer</a> | <a href="https://www.sib.swiss/privacy-policy" class="external-link" target="_blank" rel="nofollow noopener">Privacy Policy</a> </div> <div id="sib_footer_right"> </div> </div> </div> <script> if ( location.hostname == 'viralzone.expasy.org' ) { var _paq = window._paq = window._paq || []; 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